Optische Kohärenztomographie (OCT)
Anwendung und Entwicklung von ultraschnellen MHz-OCT-Systemen
Die OCT ist ein nichtinvasives Bildgebungsverfahren, welches man typischerweise nutzt um dreidimensionale Tomogramme mit hoher Auflösung (~10µm) von stark streuendem Gewebe zu erstellen. Durch die Verwendung von eigens entwickelten FDML-Lasern erreichen wir Aufnahmegeschwindigkeiten von mehreren Millionen Tiefenscans pro Sekunde (MHz-OCT). Dies ist um ein bis zwei Größenordnungen schneller als derzeitige kommerzielle Systeme.
Diese hohen Geschwindigkeiten sind in vielen klinischen Bereichen (z.B. ophthalmisches und intravaskuläres OCT) nützlich, da sie die Aufnahmedauer verringern und helfen Bewegungsartefakte zu vermeiden. Die hohe Geschwindigkeit ermöglicht aber auch einen Zugang zur Phase des detektierten Lichts und damit neue numerische Methoden zur Bildverbesserung und Kontrastgebung in der Swept-Source-OCT.
Unsere Arbeitsgruppe forscht im Bereich der OCT an neuen Technologien und zeigt mögliche Anwendungsgebiete auf.
Forschungsschwerpunkte:
- MHz-OCT - Ultraschnelle OCT-Bildgebung mit mehreren millionen Tiefenschnitten pro Sekunde
- LARA-OCT - Großflächige OCT-Bildgebung von Haut mittel Roboter unterstützer MHz-OCT
- VR-OCT - Echtzeit Berechnung und Visualisierung ganzer OCT-Volumen in einer virtuellen Umgebung
- Augen OCT - Anwendung der MHz-OCT am Auge zur Darstellung der Netzhaut oder des Augenvordergrunds
- Phasensensitive OCT - Erweiterung des Informationsgehalts einer OCT-Aufnahme durch hinzufügen eines Phasenkontrastes
- Multispektrale OCT - Kombination aus RGB- und OCT-Aufnahmen zur verbesserten Darstellung morphologischer Strukturen
zugehörige Publikationen
2005
Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates, in Optical Coherence Tomography and Coherence Techniques II , Wolfgang Drexler, Eds. SPIE, Okt.2005. pp. 58611B.
DOI: | 10.1117/12.641732 |
Bibtex: | @inproceedings{10.1117/12.641732, author = {R. Huber and K. Taira and M. Wojtkowski and J. G. Fujimoto}, title = {{Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates}}, volume = {5861}, booktitle = {Optical Coherence Tomography and Coherence Techniques II}, editor = {Wolfgang Drexler}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {58611B}, abstract = {A high speed, tunable laser using Fourier Domain Mode Locking is demonstrated for OCT imaging. Record sweep speeds up to 290 kHz, 3 cm coherence length and 145 nm range at 1300 nm are achieved.}, keywords = {Fourier domain mode locking, swept source, swept laser, tunable laser, wavelength agile laser, optical coherence tomography, spectral OCT, Fourier domain}, year = {2005}, doi = {10.1117/12.641732}, URL = {https://doi.org/10.1117/12.641732} } |
Fourier Domain Mode Locking: Overcoming limitations of frequency swept light sources and pulsed lasers, in Conference on Lasers and Electro-Optics Europe/ European Quantum Electronics Conference (CLEO/Europe - EQEC 2005) , 052005. pp. CP3-5-THU.
High-Speed, Amplified, Frequency Swept Laser at 20 kHz Sweep Rates for OCT Imaging - Technical Digest (CD), in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies , Optica Publishing Group, 052005. pp. JThE33.
DOI: | 10.1109/QELS.2005.1549239 |
Bibtex: | @inproceedings{Huber:05, author = {R. Huber and K. Taira and T. H. Ko and M. Wojtkowski and V. Srinivasan and J. G. Fujimoto and K. Hsu}, booktitle = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies}, journal = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies}, keywords = {Imaging systems; Optical coherence tomography; Lasers and laser optics; Lasers, tunable; Laser amplifiers; Laser sources; Light sources; Optical coherence tomography; Point spread function; Ring lasers}, pages = {JThE33}, publisher = {Optica Publishing Group}, title = {High-speed, amplified, frequency swept laser at 20 kHz sweep rates for OCT imaging}, year = {2005}, url = {https://opg.optica.org/abstract.cfm?URI=QELS-2005-JThE33}, abstract = {We demonstrate a high-speed, frequency swept, 1300 nm laser for Fourier domain OCT. The laser generates ~45 mW instantaneous power with 20 kHz sweep rates and achieves 108 dB sensitivity and 12.7 um resolution.}, } |
Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles, Opt. Express , vol. 13, no. 9, pp. 3513-3528, 05 2005. Optica Publishing Group.
DOI: | 10.1364/OPEX.13.003513 |
Bibtex: | @article{Huber:05, author = {R. Huber and M. Wojtkowski and K. Taira and J. G. Fujimoto and K. Hsu}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Fiber lasers; Fiber optic amplifiers; Fiber optic components; Laser sources; Light sources; Tunable diode lasers}, number = {9}, pages = {3513--3528}, publisher = {Optica Publishing Group}, title = {Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles}, volume = {13}, month = {May}, year = {2005}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-13-9-3513}, doi = {10.1364/OPEX.13.003513}, abstract = {We demonstrate a high-speed, frequency swept, 1300 nm laser source for frequency domain reflectometry and OCT with Fourier domain/swept-source detection. The laser uses a fiber coupled, semiconductor amplifier and a tunable fiber Fabry-Perot filter. We present scaling principles which predict the maximum frequency sweep speed and trade offs in output power, noise and instantaneous linewidth performance. The use of an amplification stage for increasing output power and for spectral shaping is discussed in detail. The laser generates ~45 mW instantaneous peak power at 20 kHz sweep rates with a tuning range of ~120 nm full width. In frequency domain reflectometry and OCT applications the frequency swept laser achieves 108 dB sensitivity and ~10 {\textmu}m axial resolution in tissue. We also present a fast algorithm for real time calibration of the fringe signal to equally spaced sampling in frequency for high speed OCT image preview.}, } |
Figh-speed frequency swept light source for Fourier domain OCT at 20 kHz A-scan rate, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX , Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 042005. pp. 96-100.
DOI: | 10.1117/12.592552 |
Bibtex: | @inproceedings{10.1117/12.592552, author = {Robert Huber and Kenji Taira and Maciej Wojtkowski and Tony Hong-Tyng Ko and James G. Fujimoto and Kevin Hsu}, title = {{High-speed-frequency swept light source for Fourier domain OCT at 20-kHz A-scan rate}}, volume = {5690}, booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX}, editor = {Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {96 -- 100}, abstract = {We demonstrate a high-speed tunable, continuous wave laser source for Fourier domain OCT. The laser source is based on a fiber coupled, semiconductor optical amplifier and a tunable ultrahigh finesse, fiber Fabry Perot filter for frequency tuning. The light source provides frequency scan rates of up to 20,000 sweeps per second over a wavelength range of >70 nm FWHM at 1330 nm, yielding an axial resolution of ~14 μm in air. The linewidth is narrow and corresponds to a coherence length of several mm, enabling OCT imaging over a large axial range.}, keywords = {swept source, Fourier Domain, OCT, tunable laser, Spectral Domain, frequency domain imaging, OFDI, sweep}, year = {2005}, doi = {10.1117/12.592552}, URL = {https://doi.org/10.1117/12.592552} } |
Mitarbeiter
Wolfgang Draxinger
AG Huber
Gebäude 81
,
Raum 72
wolfgang.draxinger(at)uni-luebeck.de
+49 451 3101 3229
Madita Göb
AG Huber
Gebäude 81
,
Raum 61
m.goeb(at)uni-luebeck.de
+49 451 3101 3262
Sazgar Burhan
AG Huber
Gebäude 81
,
Raum 61
sa.burhan(at)uni-luebeck.de
+49 451 3101 3263
Simon Lotz
AG Huber
Gebäude 81
,
Raum 72
si.lotz(at)uni-luebeck.de
+49 451 3101 3231
Marie Klufts
AG Huber
Gebäude 81
,
Raum 61
marie.klufts(at)uni-luebeck.de
+49 451 3101 3264