@inproceedings{Alt2002,
   author = {Alt, C and Framme, C and Schnell, S and Schuele, G and Brinkmann, R and Lin, C P},
   title = {In vivo and in vitro Selective Targeting of the Retinal Pigment Epithelium (RPE) Using a Laser-Scanning Device},
   booktitle = {Proc SPIE},
   volume = {4611},
   pages = {59-63},
   type = {Conference Proceedings},
URL = { https://doi.org/10.1117/12.470607},
year = { 2002}
}

@article{Hoerauf2002,
   author = {Hoerauf, H. and Scholz, C. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.},
   title = {Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye},
   journal = {Arch Ophthalmol},
   volume = {120},
   number = {6},
   pages = {816-9},
   note = {0003-9950 (Print)
Journal Article},
   abstract = {OBJECTIVE: To present a new imaging method for the anterior segment of the eye. METHODS: Transscleral optical coherence tomographic images were generated in healthy volunteers using a slitlamp-adapted prototype equipped with a superluminescence diode with an infrared wavelength of 1310 nm. RESULTS: The optical coherence tomographic system used allowed penetration of human sclera in vivo and high-resolution, cross-sectional imaging of the anterior chamber angle and the ciliary body. CONCLUSION: The 1310-nm optical coherence tomographic image shows a significant potential as a noninvasive diagnostic tool for the anterior segment of the eye.},
   keywords = {Anatomy, Cross-Sectional/*methods
Anterior Eye Segment/*anatomy & histology
*Diagnostic Techniques, Ophthalmological
Humans
Interferometry
Light
Sclera
Tomography/methods},
   url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12049589},
   year = { 2002},
   type = {Journal Article}
}

@inproceedings{Schuele-2002,
   author = {Schuele, Georg and Huettmann, Gereon and Brinkmann, Ralf},
   title = {Noninvasive temperature measurements during laser irradiation of the retina with optoacoustic techniques},
   editor = {Fabrice, Manns and Per, G. Soederberg and Arthur, Ho},
   publisher = {Proc. SPIE},
   volume = {4611},
   pages = {64-71},
year = { 2002},
url = { https://doi.org/10.1117/12.470601} 
}

@inproceedings{Vogel2001,
   author = {Vogel, Alfred and Brujan, Emil A and Schmidt, Peter and Nahen, Kester},
   title = {Interaction of Laser-Produced Cavitation Bubbles with Elastic Boundaries},
   booktitle = {IUTAM Symposium on Free Surface Flows},
   publisher = {Springer},
   pages = {327-335},
   ISBN = {9401038546},
   type = {Conference Proceedings},
year = { 2001}
}

@inproceedings{Vogel2001,
   author = {Vogel, Alfred and Brujan, Emil A and Schmidt, Peter and Nahen, Kester},
   title = {Interaction of laser-produced cavitation bubbles with an elastic tissue model},
   booktitle = {BiOS 2001 The International Symposium on Biomedical Optics},
   publisher = {International Society for Optics and Photonics},
   pages = {167-177},
   type = {Conference Proceedings},
URL = { https://doi.org/10.1117/12.434701},
year = { 2001}
}

@inproceedings{Rommerscheid2001,
   author = {Rommerscheid, Jan and Theisen, Dirk and Schmuecker, G. and Brinkmann, Ralf and Broll, R.},
   title = {Myocardial expression of the vascular endothelial growth factor (VEGF) after endocardial laser revascularization (ELR)},
   volume = {4433},
   pages = {39-44},
   note = {10.1117/12.446529},
   abstract = {Background. Endocardial laser revascularization (ELR) is a new technique to treat patients with severe coronary artery disease (CAD) in a percutaneous approach. The results show a significant improvement of symptoms, but the mechanism of action is still unknown. One main theory is the angiogenesis for which Vascular Endothelial Growth Factor (VEGF) is the keypromotor. We investigated immunohistochemically the VEGF-expression after ELR in porcine hearts over a timeperiod of four weeks. Methods. ELR was performed with a single-pulse Thulium:YAG laser. 15 pigs were treated with ELR and the hearts were harvested at five timeperiods: directly (group I), 3 days (group II), 1 week (group III), 2 weeks (group IV) and 4 weeks (group V) after ELR. Each group consisted of three pigs. Immunohistochemically the VEGF-expression was assessed by staining with a polyclonal antibody against VEGF and cellcounting using an expression index (VEGF-EI) Results. A maximum of VEGF-expression was found three days (group II) after ELR with a VEGF-EI of 97%. At 1 week (group III) the VEGF-EI was similar high with 93%. Along the timecourse the index decreased to 22% at 4 weeks (groupV). Conclusions. Our findings show that ELR leads to an local upregulation of VEGF around the channels. The resulting angiogenesis could be the mechanism for the relief of angina.},
   url = {http://dx.doi.org/10.1117/12.446529},
   type = {Conference Proceedings},
year = { 2001}
}

@inproceedings{Guerra2001,
   author = {Guerra III, Arnold and Venugopalan, Vasan and Nahen, Kester and Vogel, Alfred},
   title = {Experimental investigation of optical breakdown using nanosecond 532-nm and 1064-nm laser pulses delivered at high numerical aperture},
   booktitle = {BiOS 2001 The International Symposium on Biomedical Optics},
   publisher = {International Society for Optics and Photonics},
   pages = {74-82},
   type = {Conference Proceedings},
year = { 2001},
url = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/4260/0000/Experimental-investigation-of-optical-breakdown-using-nanosecond-532-nm-and/10.1117/12.426778.short}
}

@inproceedings{Brujan2000,
   author = {Brujan, Emil-Alexandru and Nahen, Kester and Schmidt, Peter and Vogel, Alfred},
   title = {Dynamics of laser-induced cavitation bubbles near an elastic boundary used as a tissue phantom},
   booktitle = {NONLINEAR ACOUSTICS AT THE TURN OF THE MILLENNIUM: ISNA 15, 15th International Symposium},
   publisher = {AIP Publishing},
   volume = {524},
   pages = {381-384},
   ISBN = {0094-243X},
   type = {Conference Proceedings},
Year = { 2000},
URL = { https://aip.scitation.org/doi/abs/10.1063/1.1309246}
}

@inproceedings{Nahen2000,
   author = {Nahen, Kester and Vogel, Alfred},
   title = {Acoustic signal characteristics during IR laser ablation and their consequences for acoustic tissue discrimination},
   booktitle = {BiOS 2000 The International Symposium on Biomedical Optics},
   publisher = {International Society for Optics and Photonics},
   pages = {166-176},
   type = {Conference Proceedings},
Year= { 2000}
}

@inproceedings{Godwin1999,
   author = {Godwin, Robert P. and Chapyak, Edward J. and Noack, J. and Vogel, A.},
   title = {Aspherical bubble dynamics and oscillation times},
   series = {OSA Technical Digest},
   publisher = {Optical Society of America},
   pages = {CTuC3},
URL = {https://doi.org/10.1117/12.350042},
Year = { 1999}
}

@inproceedings{Vogel,
   author = {Vogel, A and Scammon, R.J. and Godwin, R.P.},
   title = {Tensile stress generation by optical breakdown in tissue: experimental investigations and numerical simulations},
   booktitle = {Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical},
   publisher = {Proc. SPIE},
   volume = {3601},
   pages = {191-206},
Year = { 1999},
url = {https://doi.org/10.1117/12.350002}

}

@inproceedings{Nahen1998,
   author = {Nahen, Kester and Vogel, Alfred},
   title = {Acoustic spectroscopy of Er: YAG laser ablation of skin: first results},
   booktitle = {BiOS'98 International Biomedical Optics Symposium},
   publisher = {International Society for Optics and Photonics},
   pages = {218-229},
   type = {Conference Proceedings},
year= { 1998}
}

@inproceedings{Diddens-1992,
   author = {Diddens, H.},
   title = {Role of multidrug resistance in photodynamic therapy},
   editor = {Thomas, J. Dougherty},
   publisher = {SPIE},
   volume = {1645},
   pages = {115-123},
year = { 1992},
url = { https://doi.org/10.1117/12.60934}

}

@article{Brinkmann2006-2,
   author = {Brinkmann, R. and Roider, J. and Birngruber, R.},
   title = {Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results},
   journal = {Bull Soc Belge Ophtalmol},
   number = {302},
   pages = {51-69},
   note = {0081-0746 (Print)
Journal Article
Review},
   abstract = {Selective retina therapy (SRT) is a new laser procedure for retinal diseases that are thought to be associated with a degradation of the retinal pigment epithelium (RPE). The aim of the irradiation is to selectively damage the RPE without affecting the neural retina, the photoreceptors and the choroid. Goal of the treatment is to stimulate RPE cell migration and proliferation into the irradiated areas in order to improve the metabolism at the diseased retinal sites. In a pilot study more than 150 patients with soft drusen, retinopathia centralis serosa (RCS) and macular edema were treated. The first 3-center international trial targets diabetic macular edema and branch vein occlusion. In this review, selective RPE effects are motivated and two modalities to achieve selective RPE effects will be introduced: a pulsed and a continuous wave scanning mode. The mechanism behind selective RPE-effects will be discussed reviewing in vitro results and temperature calculations. So far clinical SRT is performed by applying trains of 30 laser pulses from a Nd:YLF-Laser (527 nm, 1.7 micros, 100 Hz) to the diseased fundus areas. In the range of 450-800 mJ/cm(2) per pulse, RPE-defects in patients were proved angiographically by fluorescein or ICG-leakage. The selectivity with respect to surrounding highly sensitive tissue and the safety range of the treatment will be reviewed. With the laser parameters used neither bleeding nor scotoma, proved by microperimetry, were observed thus demonstrating no adverse effects to the choroid and the photoreceptors, respectively. During and after irradiation, it shows that the irradiated locations are ophthalmoscopically invisible, since the effects are very limited and confined to the RPE, thus a dosimetry control is demanded. We report on a non-invasive opto-acoustic on-line technique to monitor successful RPE-irradiation and compare the data to those achieved with standard angiography one-hour post treatment.},
   keywords = {Fluorescein Angiography
Humans
Laser Coagulation/adverse effects/*methods
Multicenter Studies
Perimetry
Pigment Epithelium of Eye/pathology/surgery
Retinal Diseases/diagnosis/pathology/*surgery
Scotoma/etiology/prevention & control},
   year = {  2006}
}