@inproceedings{10.1117/12.3080934,
author = {Henrik Volkens and Christin Grill and Florian Denk and Philipp Lamminger and Sebastian Freidank and Norbert Linz and Hendrik Husstedt and Robert Huber and Ralf Brinkmann},
title = {{A home-built flexible fiber laser to investigate optimal parameters for stimulating the tympanic membrane}},
volume = {13849},
booktitle = {Optical Interactions with Tissue and Cells XXXVII},
editor = {Joel N. Bixler and Alex J. Walsh and Norbert Linz},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1384904},
abstract = {This work investigates optimizing optoacoustic stimulation of tympanic membrane models as a non-occlusive alternative to conventional acoustic drivers. We used a home-built, ytterbium-based master oscillator power amplifier (MOPA) operating at 1064 nm to stimulate an artificial tympanic membrane within a simplified middle ear model. The MOPA system can generate single laser pulses with 200 ps minimum pulse duration as well as concatenating multiple single pulses to MHz-bursts with burst durations up to 100 ns. Burst durations and burst energies were systematically varied between 30 and 100 ns and from 10 to 40 μJ. The laser-induced displacement of the membrane model was measured using phase-sensitive optical coherence tomography. Simultaneously the sound pressure level within a 0.4 ccm volume that mimics the middle ear cavity was measured. The results indicate that the membrane displacement and sound pressure increases both with higher burst energies at the same burst duration and longer burst durations at the same burst energy. Specifically, at a low burst repetition rate of 16 Hz, 100-ns pulse bursts yielded the most efficient stimulation. Furthermore, we demonstrated the system's capability for sound transmission up to 5 kHz by operating the MOPA at a repetition rate of 10 kHz. Using an acousto-optic modulator (AOM) for pulse amplitude modulation, we transmitted a speech signal onto the artificial membrane. The resulting acoustic signal was clearly audible and measurable within the middle ear model. These findings validate the feasibility of using tailored infrared laser pulses for middle ear stimulation. The ability to modulate complex audio signals via flexible, fiber-based laser architecture is a promising approach for developing next-generation hearing restoration technologies that avoid the occlusion effects and discomfort associated with traditional hearing aids.},
keywords = {Master oscillator fiber amplifier, Tympanic membrane, Temporal pulse shaping, Flexible fiber laser, Thermoelastic bending, Parameter optimization, Optical tissue stimulation},
year = {2026},
doi = {10.1117/12.3080934},
URL = {https://doi.org/10.1117/12.3080934}
}

@inproceedings{10.1117/12.3080401,
author = {Henrik Volkens and Sebastian Freidank and Philipp Lamminger and Alfred Vogel and Robert Huber and Ralf Brinkmann and Norbert Linz},
title = {{Dynamic shockwave photography using a home-built MOFA laser system with flexible repetition rate up to 5 GHz}},
volume = {PC13849},
booktitle = {Optical Interactions with Tissue and Cells XXXVII},
editor = {Joel N. Bixler and Alex J. Walsh and Norbert Linz},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {PC1384903},
abstract = {Laser-induced ablation in liquids (LAL) is widely used for nanoparticle generation, yet its underlying mechanisms are not completely understood. We investigate interactions between shockwave, cavitation bubble and target material by multi exposure imaging with high temporal and spatial resolution. Our home-built Yb-based master oscillator fiber amplifier system delivers 170 ps pulses at 2 µJ and tunable burst rates up to 5 GHz, ideal for capturing transient events. Speckle-free imaging is achieved using a fiber-based rapid optical mode mixing approach combining spectral broadening with optical delay and spatial mode mixing of frequency-doubled 532 nm pulses.},
keywords = {Laser Ablation in Liquids (LAL), Shockwave Photography, High-Speed Imaging, Multi-Exposure Illumination, Master Oscillator Fiber Amplifier (MOFA), Speckle-Free Imaging, Cavitation Bubble, Nanoparticle Generation},
year = {2026},
doi = {10.1117/12.3080401},
URL = {https://doi.org/10.1117/12.3080401}
}

@inproceedings{10.1117/12.3080520,
author = {Henrik Volkens and Philipp Lamminger and Norbert Linz and Sebastian Freidank and Robert Huber and Ralf Brinkmann},
title = {{Towards optoacoustic transient shaping using a flexible fiber laser system}},
volume = {13851},
booktitle = {Photons Plus Ultrasound: Imaging and Sensing 2026},
editor = {Alexander A. Oraevsky and Lihong V. Wang},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {138511F},
abstract = {We aim to increase the efficiency of optoacoustic signal generation for precise, in vivo, real-time tissue temperature monitoring during thermal retinal interventions, by matching the timing of multiple laser excitation events to the acoustic response of the examined specimen. To achieve this goal, we utilized a home-built Ytterbium-based master oscillator power amplifier (MOPA) fiber laser system that provides unprecedented control over the temporal pulse structure, allowing for pulse-burst durations from picoseconds to nanoseconds and arbitrary repetition rates for investigating the influence of the excitation duration on the amplitude of the resulting optoacoustic transients. Methodologically, experiments were performed on ex vivo explants of porcine retinal pigment epithelium (RPE) consisting of the RPE, choroid, and sclera embedded in a cuvette filled with saline solution. Optoacoustic transients were detected using a piezoelectric ring transducer (fres = 1 MHz, Medical Laser Center Lübeck, Germany) integrated into a standard ophthalmic contact glass with a distance of 24 mm to the specimen. We systematically investigated the influence of pulse-burst durations between 10 and 100-ns with the total burst energy of 3 μJ matching a typical probe pulse energy. Each burst was produced with a repetition rate of 500 MHz. Results demonstrate that, at typical pulse energies of 3 μJ, shorter pulse-burst durations down to 30 ns significantly increase the amplitude of the generated acoustic transients compared to longer pulse-bursts. While higher burst energy consistently results in stronger signals, signal generation efficiency is highly dependent on the temporal burst width. With decreasing burst durations, the amplitude of the resulting transients decreases lower than that of the 30-ns burst. We hypothesize that shorter excitation bursts result in a signal consisting of higher-frequency components that are stronger attenuated in water. These findings highlight that tailoring the temporal excitation profile is essential for maximizing signal-to-noise ratio. The compact and scalable fiber-based MOPA architecture offers a versatile alternative to traditional bulk lasers, providing the necessary degrees of freedom for optimized optoacoustic tissue characterization and in future real-time monitoring.},
keywords = {Master Oscillator Fiber Amplifier (MOFA), Optoacoustics, Transient shaping, Temperature measurement, Tailored optoacoustic excitation, Flexible fiber laser, Retinal laser treatment, Multi-GHz repetition rate},
year = {2026},
doi = {10.1117/12.3080520},
URL = {https://doi.org/10.1117/12.3080520}
}

@INPROCEEDINGS{11109071,
  author={Aşırım, Özüm Emre and Huber, Robert and Jirauschek, Christian},
  booktitle={2025 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Ultrashort Power-Dips in Fourier Domain Mode-Locked Lasers: Impact of Picosecond Carrier Recovery}, 
  year={2025},
  volume={},
  number={},
  pages={1-1},
  abstract={Fourier domain mode-locked (FDML) lasers are widely used in applications requiring high-speed wavelength sweeps and reliable spectral stability, such as optical coherence tomography (OCT) [1]. In this study, we explore the steady-state behavior of FDML lasers when the carrier lifetime of the semiconductor optical amplifier (SOA) is reduced to one picosecond-a scenario that can enable reduced intensity noise, improved coherence, and higher sweep speed, achievable with advanced quantum-well or quantum-dot SOAs, opening possibilities for next-generation FDML lasers [2], [3]. In previous studies, SOA carrier lifetimes longer than 70 picoseconds yielded irregular dips (holes) with varying shape, amplitude, and duration in the output power pattern, hindering beam coherence except under ultra-stable conditions [1,3-5]. Our latest simulations, which align with experimental findings in the detection and profiling of such dips [3]–[5], reveal that a 1 ps carrier lifetime improves stability and coherence but leads to emergence of consistent ultrashort, sinc-like power dips (Fig. 1, middle) for high output powers, which are almost uniform in duration (Fig. 1, right). The density of these dips increases as the output power is raised toward the upper practical limit. Based on foundational FDML laser theory [5]–[6], Equations (1)-(3) explain the formation of these ultrafast dips. At high photon flux, rapid gain depletion causes a sharp drop in carrier density $(N)$, generating a dip. Given the ultrashort carrier lifetime $(\tau_{c})$, the carriers recover quickly after depletion, restoring gain for the next dip. The time-delayed feedback term in Equation (2) represents light from previous round trips interacting with the restored carriers, amplifying the dips.},
  keywords={Semiconductor optical amplifiers;Laser mode locking;Power amplifiers;Coherence;Laser feedback;Laser stability;Stability analysis;Mathematical models;Charge carrier lifetime;Power generation},
  doi={10.1109/CLEO/Europe-EQEC65582.2025.11109071},
  ISSN={2833-1052},
  month={June},}

@inproceedings{10.1117/12.3045055,
author = {Marie Klufts and Wolfgang Draxinger and Simon Lotz and Robert Huber},
title = {{1.7MHz, 840nm swept-source ophthalmic OCT}},
volume = {13300},
booktitle = {Ophthalmic Technologies XXXV},
editor = {Daniel X. Hammer and Derek Nankivil and Yuankai K. Tao},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1330004},
keywords = {swept source, SS-OCT, FDML , Retinal imaging, ophthalmic imaging, OCT, 850 nm, short wavelength},
year = {2025},
doi = {10.1117/12.3045055},
URL = {https://doi.org/10.1117/12.3045055}
}

@inproceedings{10.1117/12.3046222,
author = {Sazgar Burhan and Berenice Schulte and Madita G{\"o}b and Awanish Pratap Singh and Bayan Mustafa and Simon Lotz and Wolfgang Draxinger and Philipp Lamminger and Yasmeine Saker and Tim Eixmann and Martin Ahrens and Marvin Heimke and Tillmann Heinze and Thilo Wedel and Maik Rahlves and Mark Ellrichmann and Robert Huber},
title = {{Switchable lateral resolution real-time MHz-OCT rectoscopy for enhanced colorectal disease diagnosis}},
volume = {13305},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIX},
editor = {Rainer A. Leitgeb and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1330512},
abstract = {Endoscopic optical coherence tomography (OCT) offers in vivo live visualization of transmural structures with histological resolution, making it a valuable tool in medical imaging. In gastroenterology, OCT endoscopy is particularly advantageous for assessing rectal wall layers, providing superior axial and lateral resolution compared to conventional rectal endoscopic ultrasound. However, the large diameter and uneven colon surface present challenges for comprehensive imaging. Extending the OCT imaging range addresses this issue by enabling a thorough examination of the entire colon, facilitating the detection of surface polyps, tumors, and their infiltration depth. Once these regions of interest are identified, high-resolution imaging becomes essential for detailed evaluation. To meet these demands, this study integrates two different imaging modes, an extended-range mode, and a high-detail mode, within a rigid rectoscope. The extended-range mode enables visualization of deeper structures, while the high-detail mode enhances image quality for precise, contact-based assessments. The system allows seamless, real-time transitions between the modes using a 3.2MHz-OCT system and a fiber‑optic MEMS switch.},
keywords = {Optical Coherence Tomography, Megahertz OCT, Fourier Domain Mode Locking, Three-dimensional image acquisition, Rectal Imaging, Long-Range Imaging, Non-Invasive Diagnostic Imaging, Tumor Assessment},
year = {2025},
doi = {10.1117/12.3046222},
URL = {https://doi.org/10.1117/12.3046222}
}

@inproceedings{10.1117/12.3046386,
author = {M. A. Bashir and M. Klufts and S. Lotz and R. Huber},
title = {{Towards ultrahigh resolution MHz retinal SS-OCT: 187nm section-wise tuning of a FDML laser at 1050nm}},
volume = {13305},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIX},
editor = {Rainer A. Leitgeb and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {133050K},
,
keywords = {wavelength-swept laser, FDML lasers, Optical coherence tomography, Fourier domain mode locked lasers, Broadband lasers, tunable lasers, swept lasers, swept source OCT},
year = {2025},
doi = {10.1117/12.3046386},
URL = {https://doi.org/10.1117/12.3046386}
}

@inproceedings{10.1117/12.3046216,
author = {Sazgar Burhan and Madita G{\"o}b and Mario Pieper and Tjalfe Laedtke and Thorge Grahl and Michael M{\"u}nter and Hinnerk Schulz-Hildebrandt and Gereon H{\"u}ttmann and Peter K{\"o}nig and Robert Huber},
title = {{Large-area dynamic contrast MHz optical coherence tomography for label-free imaging of porcine tissue}},
volume = {13305},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIX},
editor = {Rainer A. Leitgeb and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1330502},
abstract = {We demonstrate a 3.2 MHz-OCT system for inter-volumetric dynamic optical coherence tomography of ex vivo porcine kidney tissue. Employing a home-built Fourier Domain mode locking (FDML) laser with a 1310 nm wavelength, the system achieved a lateral resolution of 3.48 μm and a frame rate of 612 Hz. A motorized XYZ positioning stage enabled the precise acquisition of multiple volumes, which were seamlessly stitched together to generate a comprehensive dataset with a total area of 2.6 × 2.6 mm<sup>2</sup>. Validations against histological sections confirmed the system’s ability to visualize cellular tissue structures.},
keywords = {Optical Coherence Tomography, Megahertz OCT, Fourier Domain Mode Locking, Dynamic OCT, Functional OCT, Three-dimensional image acquisition, Tissue Dynamics, Kidney},
year = {2025},
doi = {10.1117/12.3046216},
URL = {https://doi.org/10.1117/12.3046216}
}

@inproceedings{Detrez:25,
author = {Nicolas Detrez and Dirk Theisen-Kunde and Wolfgang Draxinger and Thies H\"{o}rcher and Veit Danicke and Sazgar Burhan and Jessica Kren and Matteo Mario Bonsanto and Robert Huber and Ralf Brinkmann},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Coherence and statistical optics; Elastography; Modes; Optical coherence tomography; Phase; Phase measurement},
pages = {M3A.36},
publisher = {Optica Publishing Group},
title = {Co-Robot Supported Air-Jet Based Optical Coherence Elastography Towards In-Situ Brain Tumor Tissue Delineation},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-M3A.36},
doi = {10.1364/ECBO.2025.M3A.36},
abstract = {Accurate tumor delineation in neurosurgery is challenging. We developed an in-situ optical coherence elastography system using air-jet excitation and phase based full-range OCT. The challenges in transitioning from ex vivo to in-situ application are presented.},
}

@inproceedings{10.1117/12.3047226,
author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Ralf Brinkmann and Heinz Handels},
title = {{Enhancing brain tumor detection using optical coherence tomography and variational autoencoders}},
volume = {13410},
booktitle = {Medical Imaging 2025: Clinical and Biomedical Imaging},
editor = {Barjor S. Gimi and Andrzej Krol},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {134101P},
abstract = {Neurosurgical intervention is critical in brain tumor treatment, with long-term survival closely linked to the extent of tumor resection. The goal is to completely remove tumor tissue while preserving healthy tissue, a challenging task due to the diffuse nature of some brain tumors, such as glioblastoma, which infiltrate healthy tissue in ways that are difficult to distinguish histologically. Current intraoperative imaging techniques, including MRI and fluorescence microscopy, are limited in reliably identifying tumor tissue. Optical coherence tomography (OCT) offers a promising alternative, providing non-invasive, high-resolution cross-sectional images. This study investigates the use of a variational autoencoder (VAE) in combination with an evidential learning framework to enhance the classification of brain tissues in OCT images. The classification approach, applied to ex vivo OCT images captured at a wavelength of 1300 nm, achieved an average precision of 0.87 and a recall of 0.88 for the discrimination of healthy and tumorous brain tissue with consideration of prediction uncertainties. This method demonstrated improved discrimination between healthy white matter and tumor-infiltrated white matter compared to previous studies.},
keywords = {brain tumor, OCT, variational autoencoders, glioblastoma, classification, medical imaging, brain, evidential learning},
year = {2025},
doi = {10.1117/12.3047226},
URL = {https://doi.org/10.1117/12.3047226}
}

@inproceedings{Hohl:25,
author = {Svea H\"{o}hl and Tim Eixmann and Martin Ahrens and Noah Heldt and Peter K\"{o}nig and Ori Katz and Gereon H\"{u}ttmann},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Biomedical imaging; High speed imaging; Imaging techniques; Multicore fibers; Three dimensional imaging; Tissue imaging},
pages = {W4D.2},
publisher = {Optica Publishing Group},
title = {Holoscopic Microendoscopy},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-W4D.2},
doi = {10.1364/ECBO.2025.W4D.2},
abstract = {We present a compact endoscopic holoscopy setup using multicore fibers (MCFs) for three-dimensional imaging of scattering tissues. This method, which integrates holographic recording, enables bend-insensitive imaging, improving the potential for optical biopsies.},
}

@inproceedings{Gob:25,
author = {Madita G\"{o}b and Sazgar Burhan and Gereon H\"{u}ttmann and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Clinical applications; Imaging techniques; In vivo imaging; Optical coherence tomography; Three dimensional imaging; Tissue characterization},
pages = {Tu3C.4},
publisher = {Optica Publishing Group},
title = {In vivo Megahertz Dynamic Optical Coherence Tomography of Human Skin},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-Tu3C.4},
doi = {10.1364/ECBO.2025.Tu3C.4},
abstract = {We demonstrate Megahertz optical coherence tomography (MHz-OCT) for in vivo skin imaging with dynamic contrast at different resolutions. This study presents recent advances and discusses challenges for clinical translation and real-time in vivo applications.},
}

@inproceedings{Heldt:25,
author = {Noah Heldt and Martin Ahrens and Mario Pieper and Robert Sch\"{o}nherr and Lucie Jeschke and Peter K\"{o}nig and Marko Lampe and Gereon H\"{u}ttmann},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Biomedical imaging; Confocal microscopy; Fourier transforms; Green fluorescent protein; Imaging techniques; Optical coherence tomography},
pages = {S4B.1},
publisher = {Optica Publishing Group},
title = {Investigating dOCT signal origins and bringing a new contrast to fluorescence imaging},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-S4B.1},
doi = {10.1364/ECBO.2025.S4B.1},
abstract = {We investigated the dynamic optical coherence tomography (dOCT) signal origins by correlative measurements together with spinning disk confocal microscopy (SDM). Furthermore, we propose dynamic contrasting for detecting organelle movement signatures in the sub-second range.},
}

@inproceedings{10.1117/12.3041264,
author = {Kimberley L{\"u}hring and Birgit Lange and Lion Sch{\"u}tzeck and Ralf Brinkmann},
title = {{Laser lithotripsy: the impact of beam profile and wavelength on stone ablation}},
volume = {13293},
booktitle = {Advanced Photonics in Urology 2025},
editor = {Hyun Wook Kang and Ronald Sroka and Jian J. Zhang},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1329306},
abstract = {Thulium fiber lasers (TFL) with a peak power of 500W were introduced a few years ago for clinical use in laser lithotripsy of urinary stones. To compare the TFL with the current gold standard, the Ho:YAG laser, single pulse experiments were performed at 1.5J from different working distances using a 365μm fiber. For evaluation of the fragmentation properties of both laser systems, cuttlefish bone samples and glued BegoStone cylinders were ablated at 1.5J using different pulse durations. It was found that the TFL produced up to two times higher stone ablation compared to the Ho:YAG laser but showed significantly poorer results in fragmentation which might be explained by its lower peak power. Furthermore, the increase in the ablation efficiency of laser lithotripsy by adjusting the beam profile was investigated in this study. A series of measurements with annular and circular beam profiles of the same beam diameter was performed with the TFL. At a pulse energy of 1J the annular beam profile has removed 90% more stone volume with a single pulse.},
keywords = {laser lithotropsy, thulium fiber laser, beam profile, urolithiasis},
year = {2025},
doi = {10.1117/12.3041264},
URL = {https://doi.org/10.1117/12.3041264}
}

@inproceedings{Draxinger:25,
author = {Wolfgang Draxinger and Simon Lotz and Allegra Behr and Madita G\"{o}b and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Absolute distance measurement; Field programmable gate arrays; Imaging systems; Light sources; Scanners; Swept sources},
pages = {W5D.5},
publisher = {Optica Publishing Group},
title = {Lifting constraints on multi-kHz raster-line scanning frequency matching in multi-MHz Swept-Source OCT imaging systems},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-W5D.5},
doi = {10.1364/ECBO.2025.W5D.5},
abstract = {The established synchronization scheme of SS-OCT calls for the raster-line frequency to be a remainder-less divider of the sweep frequency. Two methods are presented that increase flexibility in scanner operation.},
}

@inproceedings{Lotz:25,
author = {Simon Lotz and Wolfgang Draxinger and Anneli Dick and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Fiber Bragg gratings; Imaging techniques; Laser sources; Optical buffers; Swept sources; Three dimensional imaging},
pages = {W5D.4},
publisher = {Optica Publishing Group},
title = {Megahertz FDML laser with on-the-fly adjustable sweep rate between 835 kHz and 13.4 MHz},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-W5D.4},
doi = {10.1364/ECBO.2025.W5D.4},
abstract = {We present a Megahertz FDML laser which can be automatically, and on-the-fly switched to speed values between 830 kHz and 13.4 MHz using optical switches in the buffer stage.},
}

@inproceedings{Singh:25,
author = {Awanish Pratap Singh and Madita G\"{o}b and Sazgar Burhan and Nikolay Tesmer and Wolfgang Draxinger and Simon Lotz and Berenice Schulte and Mark Ellrichmann and Robert Huber and Maik Rahlves},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Clinical applications; Endoscopic imaging; Imaging systems; Laser sources; Optical components; Three dimensional reconstruction},
pages = {M1C.1},
publisher = {Optica Publishing Group},
title = {Multi-MHz-OCT Endoscopic Imaging with an Automated Pullback Mechanism},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-M1C.1},
doi = {10.1364/ECBO.2025.M1C.1},
abstract = {We present an automated pullback mechanism for MHz-OCT rectoscopy to address non-uniform motion artifacts via consistent probe retraction. High-resolution images of a test sample demonstrate uniform frame spacing, reduced distortion, and improved imaging accuracy, validating its potential for in-vivo clinical applications.},
}

@inproceedings{Burhan:25,
author = {Sazgar Burhan and Madita G\"{o}b and Gereon H\"{u}ttmann and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Imaging techniques; In vivo imaging; Optical coherence tomography; Optical systems; Spatial resolution; Tissue imaging},
pages = {S4B.3},
publisher = {Optica Publishing Group},
title = {Non-Equidistant Temporal Scanning in Dynamic MHz-OCT for Higher Speed},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-S4B.3},
doi = {10.1364/ECBO.2025.S4B.3},
abstract = {We investigate advanced scanning strategies to improve speed in dynamic MHz-OCT, demonstrating that temporally non-uniform sampling outperforms uniform scanning by achieving faster imaging speeds while largely preserving image clarity.},
}

@inproceedings{Laedtke:25,
author = {Tjalfe Laedtke and Sazgar Burhan and Simon Lotz and Madita G\"{o}b and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Image registration; Imaging systems; Phase shift; Spatial resolution; Speckle noise; Speckle patterns},
pages = {W1D.4},
publisher = {Optica Publishing Group},
title = {Speckle Reduction Through Angular Compounding in Robotically Assisted MHz-OCT},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-W1D.4},
doi = {10.1364/ECBO.2025.W1D.4},
abstract = {We demonstrate speckle reduction in robotically assisted MHz-OCT by angular compounding. The robot is used to acquire images from different angles, which, after registration, are used for efficient speckle averaging without loss of spatial resolution.},
}

@inproceedings{Komeda:25,
author = {Suzuyo Komeda and Nobuhisa Tateno and Ann Marina Detje and Xibo Wang and Yue Zhu and Atsuko Furukawa and Rion Morishita and Ibrahim Abd El-Sadek and Shuichi Makita and Yoko Miura and Satoshi Matsusaka and Yoshiaki Yasuno},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Fourier transforms; Imaging techniques; Optical microscopy; Single mode fibers; Speckle noise; Spectral domain optical coherence tomography},
pages = {S4B.4},
publisher = {Optica Publishing Group},
title = {Structural and metabolic imaging of cancer spheroids by Zero-NA full-field optical coherence microscope with computational augmentations},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-S4B.4},
doi = {10.1364/ECBO.2025.S4B.4},
abstract = {High-resolution and functional imaging of in vitro samples including cancer spheroids is demonstrated with a full-field swept-source optical coherence tomography device, where computational augmentations enable long imaging depth, speckle-free imaging, and label-free cellular activity imaging.},
}

@inproceedings{Detje:25,
author = {Ann Marina Detje and Nobuhisa Tateno and Atsuko Furukawa and Rion Morishita and Yoko Miura and Satoshi Matsusaka and Yoshiaki Yasuno},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {CMOS cameras; Light sources; Optical coherence tomography; Spatial frequency; Spectral domain optical coherence tomography; Superluminescent diodes},
pages = {W3A.21},
publisher = {Optica Publishing Group},
title = {Understanding dynamic structures in breast cancer spheroid by full-field and point-scanning dynamic optical coherence tomography},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-W3A.21},
doi = {10.1364/ECBO.2025.W3A.21},
abstract = {We investigate fine dynamic structures of cancer spheroids by dynamic optical coherence tomography (DOCT) and fluorescence imaging. Small clusters of cells were found in DOCT images, and they were identified as apoptotic cells.},
}

@inproceedings{Seifert:25,
author = {Eric Seifert and Leonie Hoffmann and Xi Zhang and Lisa-Marie Fr\"{u}hauf and Yoko Miura and Ralf Brinkmann},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Absorption coefficient; Fluorescence; Laser energy; Laser light; Multimode fibers; Nd:YLF lasers},
pages = {S1E.2},
publisher = {Optica Publishing Group},
title = {Validating optoacoustic temperature determination for retinal laser treatments with the fluorescence dye ERthermAC},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-S1E.2},
doi = {10.1364/ECBO.2025.S1E.2},
abstract = {Temperature dependent fluorescence of the dye ERthermAC was used to measure laser induced temperature rise on RPE/choroid/sclera explants during simultaneous optoacoustic temperature determination, already being in clinical approval. Both methods didn't show significant differences.},
}

@inproceedings{10.1117/12.3000908,
author = {Alexander Altmann and Christian Schell and Ramtin Rahmanzadeh},
title = {{Assessing food degradation and microbial growth by sensor read-out with fluorescence spectroscopy}},
volume = {12861},
booktitle = {Frontiers in Biological Detection: From Nanosensors to Systems XVI},
editor = {Amos Danielli and Benjamin L. Miller and Sharon M. Weiss},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {128610A},
abstract = {Both the waste of edible food and the consumption of non-edible food within the best before date are ongoing concerns in food industry. Until now, no methods are applied to access food quality of packed food without opening of packages. We demonstrate the formulation of a sensor foil comprising of a non-toxic porphyrin on an inorganic matrix in polyethylene. The sensor foil is capable of detecting amines in the gas phase over food products, which could act as spoilage indicators during the shelf life of packaged food. The foil was optimized to prevent reactions with other analytes in the gas phase of food by the alteration of the hydrophobic polymer. We performed experiments, using model packing units, to monitor the behavior of the foil and correlated the change in the fluorescence spectra to the total viable count of bacteria on the fish. The readout of the foils was performed with fluorescence spectroscopy to yield highly accurate results in contrast to less accurate the colorimetric determination.},
keywords = {fluorescence spectroscopy, gas sensing, amine sensor, food safety, porphyrins},
year = {2024},
doi = {10.1117/12.3000908},
URL = {https://doi.org/10.1117/12.3000908}
}

@inproceedings{10.1117/12.3000912,
author = {Alexander Altmann and Mohammad Khodaygani and Martin Leucker and Christian Schell and Ramtin Rahmanzadeh},
title = {{Detection of spoiled food along the supply chain with novel sensors for packed food}},
volume = {12879},
booktitle = {Photonic Technologies in Plant and Agricultural Science},
editor = {Dag Heinemann and Gerrit Polder},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1287906},
abstract = {Along food supply chains, several critical steps can lead to inconsumable food. Especially food of animal origin undergoes rapid aging, when stored inadequately. Quality assessment of packaged food products faces serious problems ranging from the loss of integrity of the package to damage of the food and it is applied only to a low number of samples per batch. As a result, food products are either wasted or not analyzed, which results in a significant decrease in food safety. As a part of an intelligent packaging system, we designed a sensor foil that can detect amines, produced during the food aging process. Change of the fluorescence of the sensor foil can be assessed with spectroscopy or color change from green to red can be detected optically with a camera, e.g. by smartphone. The foil can be incorporated inside the single packaging units and noninvasively measured routinely by the store or consumer. The readout of the foils was performed with steady-state tabletop spectrometers, which were then compared to the results for readouts with different inexpensive handheld devices that could be used during real-life applications, e.g., at any step in a food supply chain.  Ideally, the single food product is linked to a single foil at the primary producer, measuring the first spectrum and connecting the data to the specific product, e.g. via distributed ledger. For a transparent process chain, QR-codes could be utilized to allow access to the freshness data along the shelf life of a single package. },
keywords = {fluorescence spectroscopy, gas sensing, amine sensor, food safety, porphyrins, SVM classifier, block chain, non-destructive food testing},
year = {2024},
doi = {10.1117/12.3000912},
URL = {https://doi.org/10.1117/12.3000912}
}