2023

Paula Enzian, and Ramtin Rahmanzadeh,
Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer, Pharmaceutics , vol. 15, no. 8, 07 2023.
DOI:10.3390/pharmaceutics15082040
Datei: 2040
Bibtex: BibTeX
@Article{pharmaceutics15082040,
AUTHOR = {Enzian, Paula and Rahmanzadeh, Ramtin},
TITLE = {Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer},
JOURNAL = {Pharmaceutics},
VOLUME = {15},
YEAR = {2023},
NUMBER = {8},
ARTICLE-NUMBER = {2040},
URL = {https://www.mdpi.com/1999-4923/15/8/2040},
ISSN = {1999-4923},
ABSTRACT = {Head and neck squamous cell carcinoma (HNSCC) still represents the world’s sixth most common tumor entity, with increasing incidence. The reachability of light makes HNSCC suitable for light-based therapies such as Photochemical Internalization (PCI). The drug Bleomycin is cytotoxic and used as an anti-tumor medication. Since Bleomycin is endocytosed as a relatively large molecule, part of it is degraded in lysosomes before reaching its intracellular target. The goal of our study was to improve the intracellular availability of Bleomycin with PCI. We investigate the intracellular delivery of Bleomycin after PCI with the photosensitizer Fimaporfin. A systematic variation of Bleomycin and Fimaporfin concentrations and light irradiation led to the pronounced cell death of HNSCC cells. After optimization, the same level of tumor cell death of 75% was reached with a 20-fold lower Bleomycin concentration. This would allow treatment of HNSCC with high local tumor cell death and reduce the side effects of Bleomycin, e.g., lung fibrosis, at the same time. This demonstrates the increased efficacy of the anti-tumor medication Bleomycin in combination with PCI.},
DOI = {10.3390/pharmaceutics15082040}
}
Svenja Sonntag, Marie Kreikenbohm, Giulia Böhmerle, Jessica Stagge, Salvatore Grisanti, and Yoko Miura,
Impact of cigarette smoking on fluorescence lifetime of ocular fundus, Scientific Reports , vol. 13, no. 1, pp. 11484, 07 2023.
DOI:10.1038/s41598-023-37484-4
Datei: s41598-023-37484-4
Bibtex: BibTeX
@article{RN5446,
   author = {Sonntag, Svenja Rebecca;Kreikenbohm, Marie;Böhmerle, Giulia;Stagge, Jessica;Grisanti, Salvatore and Miura, Yoko},
   title = {Impact of cigarette smoking on fluorescence lifetime of ocular fundus},
   journal = {Scientific Reports},
   volume = {13},
   number = {1},
   pages = {11484},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-023-37484-4},
   url = {https://doi.org/10.1038/s41598-023-37484-4},
   year = {2023},
   type = {Journal Article}
}
Philipp Lamminger, Hubertus Hakert, Simon Lotz, Jan Philip Kolb, Tonio Kutscher, Sebastian Karpf, and Robert Huber,
Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm, Opt. Lett. , vol. 48, no. 14, pp. 3713-3716, 07 2023. Optica Publishing Group.
DOI:10.1364/OL.488181
Bibtex: BibTeX
@article{Lamminger:23,
author = {Philipp Lamminger and Hubertus Hakert and Simon Lotz and Jan Philip Kolb and Tonio Kutscher and Sebastian Karpf and Robert Huber},
journal = {Opt. Lett.},
keywords = {Green fluorescent protein; Laser beam combining; Laser crystals; Laser imaging; Optical amplifiers; Photonic crystal lasers},
number = {14},
pages = {3713--3716},
publisher = {Optica Publishing Group},
title = {Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm},
volume = {48},
month = {Jul},
year = {2023},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-14-3713},
doi = {10.1364/OL.488181},
abstract = {Four-wave mixing (FWM) enables the generation and amplification of light in spectral regions where suitable fiber gain media are unavailable. The 1300 nm and 900 nm regions are of especially high interest for time-encoded (TICO) stimulated Raman scattering microscopy and spectro-temporal laser imaging by diffracted excitation (SLIDE) two-photon microscopy. We present a new, to the best of our knowledge, FWM setup where we shift the power of a home-built fully fiber-based master oscillator power amplifier (MOPA) at 1064 nm to the 1300-nm region of a rapidly wavelength-sweeping Fourier domain mode-locked (FDML) laser in a photonic crystal fiber (PCF) creating pulses in the 900-nm region. The resulting 900-nm light can be wavelength swept over 54 nm and has up to 2.5 kW (0.2 {\textmu}J) peak power and a narrow instantaneous spectral linewidth of 70 pm. The arbitrary pulse patterns of the MOPA and the fast wavelength tuning of the FDML laser (419 kHz) allow it to rapidly tune the FWM light enabling new and faster TICO-Raman microscopy, SLIDE imaging, and other applications.},
}
Anke Leichtle, Zuzana Penxova, Thorge Kempin, David Leffers, Martin Ahrens, Peter König, Ralf Brinkmann, Gereon Hüttmann, Karl-Ludwig Bruchhage, and Hinnerk Schulz-Hildebrandt,
Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media, Photonics , vol. 10, no. 6, 06 2023.
DOI:10.3390/photonics10060685
Datei: 685
Bibtex: BibTeX
@Article{photonics10060685,
AUTHOR = {Leichtle, Anke and Penxova, Zuzana and Kempin, Thorge and Leffers, David and Ahrens, Martin and König, Peter and Brinkmann, Ralf and Hüttmann, Gereon and Bruchhage, Karl-Ludwig and Schulz-Hildebrandt, Hinnerk},
TITLE = {Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media},
JOURNAL = {Photonics},
VOLUME = {10},
YEAR = {2023},
NUMBER = {6},
ARTICLE-NUMBER = {685},
URL = {https://www.mdpi.com/2304-6732/10/6/685},
ISSN = {2304-6732},
ABSTRACT = {Hypothesis: Otitis media (OM) can be successfully visualized and diagnosed by dynamic microscopic optical coherence tomography (dmOCT). Background: OM is one of the most common infectious diseases and, according to the WHO, one of the leading health problems with high mortality in developing countries. Despite intensive research, the only definitive treatment of therapy-refractory OM for decades has been the surgical removal of inflamed tissue. Thereby, the intra-operative diagnosis is limited to the surgeon’s visual impression. Supportive imaging modalities have been little explored and have not found their way into clinical application. Finding imaging techniques capable of identifying inflamed tissue intraoperatively, therefore, is of significant clinical relevance. Methods: This work investigated a modified version of optical coherence tomography with a microscopic resolution (mOCT) regarding its ability to differentiate between healthy and inflamed tissue. Despite its high resolution, the differentiation of single cells with mOCT is often impossible. A new form of mOCT termed dynamic mOCT (dmOCT) achieves cellular contrast using micro-movements within cells based on their metabolism. It was used in this study to establish correlative measurements with histology. Results: Using dmOCT, images with microscopic resolution were acquired on ex vivo tissue samples of chronic otitis media and cholesteatoma. Imaging with dmOCT allowed the visualization of specific and characteristic cellular and subcellular structures in the cross-sectional images, which can be identified only to a limited extent in native mOCT. Conclusion: We demonstrated for the first time a new marker-free visualization in otitis media based on intracellular motion using dmOCT.},
DOI = {10.3390/photonics10060685}
}
Michael Schmalz, Xiao-Xuan Liang, Ines Wieser, Caroline Gruschel, Lukas Muskalla, Martin Thomas Stöckl, Roland Nitschke, Norbert Linz, Alfred Leitenstorfer, Alfred Vogel, and Elisa Ferrando-May,
Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling, Proceedings of the National Academy of Sciences , vol. 120, no. 25, pp. e2220132120, 06 2023.
DOI:10.1073/pnas.2220132120
Datei: pnas.2220132120
Bibtex: BibTeX
@article{
doi:10.1073/pnas.2220132120,
author = {Michael Schmalz  and Xiao-Xuan Liang  and Ines Wieser  and Caroline Gruschel  and Lukas Muskalla  and Martin Thomas Stöckl  and Roland Nitschke  and Norbert Linz  and Alfred Leitenstorfer  and Alfred Vogel  and Elisa Ferrando-May },
title = {Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling},
journal = {Proceedings of the National Academy of Sciences},
volume = {120},
number = {25},
pages = {e2220132120},
year = {2023},
doi = {10.1073/pnas.2220132120},
URL = {https://www.pnas.org/doi/abs/10.1073/pnas.2220132120},
eprint = {https://www.pnas.org/doi/pdf/10.1073/pnas.2220132120},
abstract = {Understanding and predicting the outcome of the interaction of light with DNA has a significant impact on the study of DNA repair and radiotherapy. We report on a combination of femtosecond pulsed laser microirradiation at different wavelengths, quantitative imaging, and numerical modeling that yields a comprehensive picture of photon-mediated and free-electron-mediated DNA damage pathways in live cells. Laser irradiation was performed under highly standardized conditions at four wavelengths between 515 nm and 1,030 nm, enabling to study two-photon photochemical and free-electron-mediated DNA damage in situ. We quantitatively assessed cyclobutane pyrimidine dimer (CPD) and γH2AX-specific immunofluorescence signals to calibrate the damage threshold dose at these wavelengths and performed a comparative analysis of the recruitment of DNA repair factors xeroderma pigmentosum complementation group C (XPC) and Nijmegen breakage syndrome 1 (Nbs1). Our results show that two-photon-induced photochemical CPD generation dominates at 515 nm, while electron-mediated damage dominates at wavelengths ≥620 nm. The recruitment analysis revealed a cross talk between nucleotide excision and homologous recombination DNA repair pathways at 515 nm. Numerical simulations predicted electron densities and electron energy spectra, which govern the yield functions of a variety of direct electron-mediated DNA damage pathways and of indirect damage by •OH radicals resulting from laser and electron interactions with water. Combining these data with information on free electron–DNA interactions gained in artificial systems, we provide a conceptual framework for the interpretation of the wavelength dependence of laser-induced DNA damage that may guide the selection of irradiation parameters in studies and applications that require the selective induction of DNA lesions.}}
Alexander Altmann, Michel Eden, Gereon Hüttmann, Christian Schell, and Ramtin Rahmanzadeh,
Porphyrin-based sensor films for monitoring food spoilage, Food Packaging and Shelf Life , vol. 38, pp. 101105, 06 2023.
DOI:https://doi.org/10.1016/j.fpsl.2023.101105
Datei: S2214289423000820
Bibtex: BibTeX
@article{ALTMANN2023101105,
title = {Porphyrin-based sensor films for monitoring food spoilage},
journal = {Food Packaging and Shelf Life},
volume = {38},
pages = {101105},
year = {2023},
issn = {2214-2894},
doi = {https://doi.org/10.1016/j.fpsl.2023.101105},
url = {https://www.sciencedirect.com/science/article/pii/S2214289423000820},
author = {Alexander Altmann and Michel Eden and Gereon Hüttmann and Christian Schell and Ramtin Rahmanzadeh},
keywords = {Biogenic amines, Sensors, Fish freshness, Food safety, Porphyrin, Smart packaging},
abstract = {To increase food safety and to minimize food waste, it is interesting for the food industry and consumers to be able to determine food spoilage continuously and non-destructively. When food of animal origin is degraded, amines are released as protein breakdown products, which could be used to monitor the freshness of meat and fish. In this work, we introduce a porphyrin-based sensor foil aimed at the detection of biogenic amines. The sensor-porphyrin is formulated on mesoporous silica. Reactivity towards moderate humidity was eliminated by dispersion of the functionalized silica in polyethylene (PE), followed by thermal extrusion resulting in PE foils. After exposure to amines, the sensor foil changes its color irreversibly from green to red. The color change is accompanied by a pronounced shift of the fluorescence spectrum, which was used as a sensitive method to detect the degradation of fish products in model experiments. Titanium dioxide particles in the foil increased the detected fluorescence emission. Experiments with fish filets showed the applicability of the sensor foils in a real-life application by indicating the degree of spoilage after several days, while the microbial growth was depicted by total viable count. We anticipate that our sensor can be an integral part of smart food packages, helping to track the freshness of food during transport or storage.}
}
Sarah Latus, Sarah Grube, Tim Eixmann, Maximilian Neidhardt, Stefan Gerlach, Robin Mieling, Gereon Hüttmann, Matthias Lutz, and Alexander Schlaefer,
A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography, IEEE Transactions on Biomedical Engineering , pp. 1-9, 05 2023.
DOI:10.1109/TBME.2023.3275539
Bibtex: BibTeX
@ARTICLE{10122996,

  author={Latus, Sarah and Grube, Sarah and Eixmann, Tim and Neidhardt, Maximilian and Gerlach, Stefan and Mieling, Robin and Hüttmann, Gereon and Lutz, Matthias and Schlaefer, Alexander},

  journal={IEEE Transactions on Biomedical Engineering}, 

  title={A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography}, 

  year={2023},

  volume={},

  number={},

  pages={1-9},

  doi={10.1109/TBME.2023.3275539}}
Patrick Kuppler, Paul Strenge, Birgit Lange, Sonja Spahr-Hess, Wolfgang Draxinger, Christian Hagel, Dirk Theisen-Kunde, Ralf Brinkmann, Robert Huber, Volker Tronnier, and Matteo Mario Bonsanto,
The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study, Frontiers in Oncology , vol. 13, 04 2023.
DOI:10.3389/fonc.2023.1151149
Datei: fonc.2023.1151149
Bibtex: BibTeX
Kuppler P, Strenge P, Lange B, Spahr-Hess S, Draxinger W, Hagel C, Theisen-Kunde D, Brinkmann R, Huber R, Tronnier V and Bonsanto MM (2023) The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study. Front. Oncol. 13:1151149. doi: 10.3389/fonc.2023.1151149
Alessa Hutfilz, Dirk Theisen-Kunde, Matteo M. Bonsanto, and Ralf Brinkmann,
Pulsed thulium laser blood vessel haemostasis as an alternative to bipolar forceps during neurosurgical tumour resection, Lasers in Medical Science , vol. 38, pp. 94, 03 2023. https://doi.org/10.1007/s10103-023-03747-9 .
DOI:10.1007/s10103-023-03747-9
Weblink: https://doi.org/10.1007/s10103-023-03747-9
Bibtex: BibTeX
@article{RN5430,
   author = {Hutfilz, Alessa;Theisen-Kunde, Dirk;Bonsanto, Matteo Mario and Brinkmann, Ralf},
   title = {Pulsed thulium laser blood vessel haemostasis as an alternative to bipolar forceps during neurosurgical tumour resection},
   journal = {Lasers in Medical Science},
   volume = {38},
   number = {1},
   pages = {94},
   ISSN = {1435-604X},
   DOI = {10.1007/s10103-023-03747-9},
   url = {https://doi.org/10.1007/s10103-023-03747-9},
   year = {2023},
   type = {Journal Article}
}
Thomas Gottschall, Tobias Meyer-Zedler, Matthias Eibl, Tom Pfeiffer, Hubertus Hakert, Michael Schmitt, Robert Huber, Andreas Tünnermann, Jens Limpert, and Juergen Popp,
Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy, The Journal of Physical Chemistry B , pp. null, 03 2023.
DOI:10.1021/acs.jpcb.2c09115
Datei: acs.jpcb.2c09115
Bibtex: BibTeX
@article{doi:10.1021/acs.jpcb.2c09115,
author = {Gottschall, Thomas and Meyer-Zedler, Tobias and Eibl, Matthias and Pfeiffer, Tom and Hakert, Hubertus and Schmitt, Michael and Huber, Robert and Tünnermann, Andreas and Limpert, Jens and Popp, Juergen},
title = {Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy},
journal = {The Journal of Physical Chemistry B},
volume = {0},
number = {0},
pages = {null},
year = {0},
doi = {10.1021/acs.jpcb.2c09115},
    note ={PMID: 36917762},
URL = {https://doi.org/10.1021/acs.jpcb.2c09115},
eprint = { https://doi.org/10.1021/acs.jpcb.2c09115}
}
Manabu Yamamoto, Yoko Miura, Kumiko Hirayama, Akika Kyo, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, and Shigeru Honda,
Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy, Life , vol. 13, no. 3, pp. 769, 03 2023.
DOI:10.3390/life13030769
Datei: 769
Bibtex: BibTeX
@article{RN5362,
   author = {Yamamoto, Manabu;Miura, Yoko;Hirayama, Kumiko;Kyo, Akika;Kohno, Takeya;Theisen-Kunde, Dirk;Brinkmann, Ralf and Honda, Shigeru},
   title = {Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy},
   journal = {Life},
   volume = {13},
   number = {3},
   pages = {769},
   ISSN = {2075-1729},
   DOI = {10.3390/life13030769},
   url = {https://www.mdpi.com/2075-1729/13/3/769},
   year = {2023},
   type = {Journal Article}
}
Matthias Strauch, Jan Philip Kolb, Christian Rose, Nadine Merg, Jennifer Hundt, Christiane Kümpers, Sven Perner, Sebastian Karpf, and Robert Huber,
Accelerating intraoperative tumor histology with sectioning-free multiphoton microscopy, European Journal of Surgical Oncology , vol. 49, no. 2, pp. e210, 02 2023.
DOI:https://doi.org/10.1016/j.ejso.2022.11.575
Datei: S0748798322013245
Bibtex: BibTeX
@article{STRAUCH2023e210,
title = {Accelerating intraoperative tumor histology with sectioning-free multiphoton microscopy},
journal = {European Journal of Surgical Oncology},
volume = {49},
number = {2},
pages = {e210},
year = {2023},
issn = {0748-7983},
doi = {https://doi.org/10.1016/j.ejso.2022.11.575},
url = {https://www.sciencedirect.com/science/article/pii/S0748798322013245},
author = {Matthias Strauch and Jan Philip Kolb and Christian Rose and Nadine Merg and Jennifer Hundt and Christiane Kümpers and Sven Perner and Sebastian Karpf and Robert Huber}
}
Leo Puyo, Clara Pfäffle, Hendrik Spahr, Jonas Franke, Daniel Bublitz, Dierck Hillmann, and Gereon Hüttmann,
Diffuse-illumination holographic optical coherence tomography, Opt. Express , vol. 31, no. 20, pp. 33500--33517, 2023. Optica Publishing Group.
DOI:10.1364/OE.498654
Datei: abstract.cfm
Bibtex: BibTeX
@article{Puyo:23,
author = {L\'{e}o Puyo and Clara Pf\"{a}ffle and Hendrik Spahr and Jonas Franke and Daniel Bublitz and Dierck Hillmann and Gereon H\"{u}ttmann},
journal = {Opt. Express},
keywords = {Fourier optics; Full field optical coherence tomography; Image quality; Imaging techniques; Spatial frequency; Spatial light modulators},
number = {20},
pages = {33500--33517},
publisher = {Optica Publishing Group},
title = {Diffuse-illumination holographic optical coherence tomography},
volume = {31},
month = {Sep},
year = {2023},
url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-31-20-33500},
doi = {10.1364/OE.498654},
abstract = {Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing diffuse illumination of numerical aperture (NA) equal to the detection NA. While the reduction of speckle from singly scattered light is only modest, we discovered that speckle from multiply scattered light can be arbitrarily reduced, resulting in substantial improvements in image quality. This technique also offers the advantage of suppressing noises arising from spatial coherence, and can be implemented with a partially spatially incoherent light source for further mitigation of multiple scattering. Finally, we show that although holographic reconstruction capabilities are increasingly lost with decreasing spatial coherence, they can be retained over an axial range sufficient to standard OCT applications.},
}
Stefan Meyer, Tonio F. Kutscher, Philipp Lamminger, Florian Sommer, and Sebastian Karpf,
Leveraging the periodic interference condition in electro-optic modulators for picosecond pulse generation, Opt. Continuum , vol. 2, no. 11, pp. 2298--2307, 2023. Optica Publishing Group.
DOI:10.1364/OPTCON.500969
Datei: abstract.cfm
Bibtex: BibTeX
@article{Meyer:23,
author = {Stefan Meyer and Tonio F. Kutscher and Philipp Lamminger and Florian Sommer and Sebastian Karpf},
journal = {Opt. Continuum},
keywords = {Femtosecond pulses; Fluorescence lifetime imaging; Phase modulation; Picosecond pulses; Single mode lasers; Ultrashort pulses},
number = {11},
pages = {2298--2307},
publisher = {Optica Publishing Group},
title = {Leveraging the periodic interference condition in electro-optic modulators for picosecond pulse generation},
volume = {2},
month = {Nov},
year = {2023},
url = {https://opg.optica.org/optcon/abstract.cfm?URI=optcon-2-11-2298},
doi = {10.1364/OPTCON.500969},
abstract = {Ultra-short optical pulses in the femtosecond and picosecond regime are typically generated using mode-locked lasers. However, in mode-locking, the pulse repetition rate is fundamentally linked to the cavity length of the laser, making it difficult to synchronize these laser pulses to other light sources. Here, we apply a pulse-on-demand approach to picosecond pulse generation with an electro-optic intensity modulator (EOM). The high, 40 GHz bandwidth of the EOM enables low picosecond pulses, however it shifts the problem of pulse generation to the electronic pulses, requiring high bandwidth electronics. In this study, we present an electro-optic operation, leveraging the periodic interference condition of intensity EOMs by operating it with rising edges at twice its V$\pi$ voltage. Utilizing this method, pulse durations as short as 10.9 ps were achieved by employing a 35 ps edge from an arbitrary waveform generator. The pulses were measured directly on a high-speed oscilloscope as well as indirectly through the spectral broadening of the generated optical pulses. We employ this approach to show arbitrary pulse length generation by applying step functions with only one V$\pi$ voltage, thus permitting direct pulse-on-demand generation of pulses with arbitrary pulse length, shape and repetition rate for applications in spectroscopy, sensing and nonlinear imaging.},
}
Lei Fu, Xiao-Xuan Liang, Sijia Wang, Siqi Wang, Ping Wang, Zhenxi Zhang, Jing Wang, Alfred Vogel, and Cuiping Yao,
Laser induced spherical bubble dynamics in partially confined geometry with acoustic feedback from container walls, Ultrasonics Sonochemistry , vol. 101, pp. 106664, 2023.
DOI:https://doi.org/10.1016/j.ultsonch.2023.106664
Datei: S1350417723003760
Bibtex: BibTeX
@article{FU2023106664,
title = {Laser induced spherical bubble dynamics in partially confined geometry with acoustic feedback from container walls},
journal = {Ultrasonics Sonochemistry},
volume = {101},
pages = {106664},
year = {2023},
issn = {1350-4177},
doi = {https://doi.org/10.1016/j.ultsonch.2023.106664},
url = {https://www.sciencedirect.com/science/article/pii/S1350417723003760},
author = {Lei Fu and Xiao-Xuan Liang and Sijia Wang and Siqi Wang and Ping Wang and Zhenxi Zhang and Jing Wang and Alfred Vogel and Cuiping Yao},
keywords = {Laser-induced cavitation, Partial confinement, Acoustic feedback, Elastic wall, Vibrations, Extended Rayleigh-Plesset model},
abstract = {We investigated laser-induced cavitation dynamics in a small container with elastic thin walls and free or partially confined surface both experimentally and by numerical investigations. The cuvette was only 8–25 times larger than the bubble in its center. The liquid surface was either free, or two thirds were confined by a piston-shaped pressure transducer. Different degrees of confinement were realized by filling the liquid up to the transducer surface or to the top of the cuvette. For reference, some experiments were performed in free liquid. We recorded the bubble dynamics simultaneously by high-speed photography, acoustic measurements, and detection of probe beam scattering. Simultaneous single-shot recording of radius-time curves and oscillation times enabled to perform detailed investigations of the bubble dynamics as a function of bubble size, acoustic feedback from the elastic walls, and degree of surface confinement. The bubble dynamics was numerically simulated using a Rayleigh-Plesset model extended by terms describing the acoustically mediated feedback from the bubble’s environment. Bubble oscillations were approximately spherical as long as no secondary cavitation by tensile stress occurred. Bubble expansion was always similar to the dynamics in free liquid, and the environment influenced mainly the collapse phase and subsequent oscillations. For large bubbles, strong confinement led to a slight reduction of maximum bubble size and to a pronounced reduction of the oscillation time, and both effects increased with bubble size. The joint action of breakdown-induced shock wave and bubble expansion excites cuvette wall vibrations, which produce alternating pressure waves that are focused onto the bubble. This results in a prolongation of the collapse phase and an enlargement of the second oscillation, or in time-delayed re-oscillations. The details of the bubble dynamics depend in a complex manner on the degree of surface confinement and on bubble size. Numerical simulations of the first bubble oscillation agreed well with experimental data. They suggest that the alternating rarefaction/compression waves from breakdown-induced wall vibrations cause a prolongation of the first oscillation. By contrast, liquid mass movement in the cuvette corners result in wall vibrations causing late re-oscillations. The strong and rich interaction between the bubble and its surroundings may be relevant for a variety of applications such as intraluminal laser surgery and laser-induced cavitation in microfluidics.}
}
Tonio F. Kutscher, Philipp Lamminger, Anton Gruber, Christina Leonhardt, Annika Hunold, Robert A. Huber, and Sebastian Karpf,
Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm, Opt. Lett. , vol. 48, no. 23, pp. 6096--6099, 2023. Optica Publishing Group.
DOI:10.1364/OL.500943
Datei: abstract.cfm
Bibtex: BibTeX
@article{Kutscher:23,
author = {Tonio F. Kutscher and Philipp Lamminger and Anton Gruber and Christina Leonhardt and Annika Hunold and Robert A. Huber and Sebastian Karpf},
journal = {Opt. Lett.},
keywords = {Erbium-doped fiber amplifiers; Laser imaging; Laser sources; Lidar; Multiphoton microscopy; Picosecond pulses},
number = {23},
pages = {6096--6099},
publisher = {Optica Publishing Group},
title = {Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm},
volume = {48},
month = {Dec},
year = {2023},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-23-6096},
doi = {10.1364/OL.500943},
abstract = {Swept-source lasers are versatile light sources for spectroscopy, imaging, and microscopy. Swept-source-powered multiphoton microscopy can achieve high-speed, inertia-free point scanning with MHz line-scan rates. The recently introduced spectro-temporal laser imaging by diffractive excitation (SLIDE) technique employs swept-source lasers to achieve kilohertz imaging rates by using a swept-source laser in combination with a diffraction grating for point scanning. Multiphoton microscopy at a longer wavelength, especially in the shortwave infrared (SWIR) region, can have advantages in deep tissue penetration or applications in light detection and ranging (LiDAR). Here we present a swept-source laser around 1550 nm providing high-speed wavelength agility and high peak power pulses for nonlinear excitation. The swept-source laser is a Fourier-domain mode-locked (FDML) laser operating at 326 kHz sweep rate. For high peak powers, the continuous wave (cw) output is pulse modulated to short picosecond pulses and amplified using erbium-doped fiber amplifiers (EDFAs) to peak powers of several kilowatts. This FDML-master oscillator power amplifier (FDML-MOPA) setup uses reliable, low-cost fiber components. As proof-of-principle measurement, we show third-harmonic generation (THG) using harmonic nanoparticles at the 10 MHz pulse excitation rate. This new, to the best of our knowledge, laser source provides unique performance parameters for applications in nonlinear microscopy, spectroscopy, and ranging.},
}

2022

Özüm Emre Aşırım, Robert Huber, and Christian Jirauschek,
Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers, Applied Physics B , vol. 18(12), Nov. 2022.
DOI:10.1007/s00340-022-07933-5
Bibtex: BibTeX
@article{RN5426,
   author = {Aşırım, Özüm Emre;Huber, Robert and Jirauschek, Christian},
   title = {Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers},
   journal = {Applied Physics B},
   volume = {128},
   number = {12},
   pages = {218},
   ISSN = {1432-0649},
   DOI = {10.1007/s00340-022-07933-5},
   url = {https://doi.org/10.1007/s00340-022-07933-5},
   year = {2022},
   type = {Journal Article}
}
Caren Jacobi, Madita Göb, Robert Huber, Ralf. J. Ludwig, and Jennifer Hundt,
620 Screening an inhibitor library for new drug candidates to promote wound healing, Journal of Investigative Dermatology , vol. 142, no. 12, Supplement, pp. S288, Nov. 2022.
DOI:https://doi.org/10.1016/j.jid.2022.09.637
Datei: S0022202X22025714
Bibtex: BibTeX
@article{JACOBI2022S288,
title = {620 Screening an inhibitor library for new drug candidates to promote wound healing},
journal = {Journal of Investigative Dermatology},
volume = {142},
number = {12, Supplement },
pages = {S288},
year = {2022},
note = {ESDR 2022 Meeting Abstract Supplement},
issn = {0022-202X},
doi = {https://doi.org/10.1016/j.jid.2022.09.637},
url = {https://www.sciencedirect.com/science/article/pii/S0022202X22025714},
author = {C. Jacobi and M. Göb and R. Huber and R.J. Ludwig and J.E. Hundt}
}
Linh Ha-Wissel, Handan Yasak, Robert Huber, Detlef Zillikens, Ralf J. Ludwig, Diamant Thaci, and Jennifer E. Hundt,
Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis, Frontiers in Medicine , vol. 9, 09 2022.
DOI:10.3389/fmed.2022.995883
Datei: fmed.2022.995883
Bibtex: BibTeX
@article{RN5359,
   author = {Ha-Wissel, L.;Yasak, H.;Huber, R.;Zillikens, D.;Ludwig, R. J.;Thaçi, D. and Hundt, J. E.},
   title = {Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis},
   journal = {Front Med (Lausanne)},
   volume = {9},
   pages = {995883},
   ISSN = {2296-858X (Print)
2296-858x},
   DOI = {10.3389/fmed.2022.995883},
   year = {2022},
   type = {Journal Article}
}
Paul Strenge, Birgit Lange, Wolfgang Draxinger, Christin Grill, Veit Danicke, Dirk Theisen-Kunde, Christian Hagel, Sonja Spahr-Hess, Matteo M. Bonsanto, Heinz Handels, Ralf Brinkmann, and Robert Huber,
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
DOI:10.3389/fonc.2022.896060
Bibtex: BibTeX
@article{Strenge-2022,
   author = {Strenge, P.;Lange, B.;Grill,C.;Danicke,V.;Theisen-Kunde, D.;Hagel, C.;Spahr-Hess, S.;;Bonsanto, Matteo M.;Handels, H.; and Huber, R.;Brinkmann, R.},
   title = {Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology},
   journal = {Frontiers in Oncology},
Keywords = {AG-Huber_FDML, AG-Huber_OCT, brain, tumor, glioblastoma multiforme, OCT, neural network, attenuation (absorption)
coefficient, optical coherence tomography},
   DOI = {https://doi.org/10.3389/fonc.2022.896060},
   url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.896060/full},
   year = {2022},
   type = {Journal Article}
}
Christin Grill, Torben Blömker, Mark Schmidt, Dominic Kastner, Tom Pfeiffer, Jan Philip Kolb, Wolfgang Draxinger, Sebastian Karpf, Christian Jirauschek, and Robert Huber,
Towards phase-stabilized Fourier domain mode-locked frequency combs, Communications Physics , vol. 5, no. 1, 08 2022. Springer Science and Business Media LLC.
DOI:10.1038/s42005-022-00960-w
Bibtex: BibTeX
@article{Grill2022,
  doi = {10.1038/s42005-022-00960-w},
  year = {2022},
  publisher = {Springer Science and Business Media {LLC}},
  volume = {{5}},
  number = {{1}},
  author = {C. Grill, T. Bl\"{o}mker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber},
  title = {Towards phase-stabilized Fourier domain mode-locked frequency combs},
  journal = {{Communications Physics}},
keywords={AG-Huber_FDML, FDML, Fourier domain mode locking, phase, frequency comb, coherence, beating}
}
Paul Strenge, Birgit Lange, Christin Grill, Wolfgang Draxinger, Veit Danicke, Dirk Theisen-Kunde, Christian Hagel, Sonja Spahr-Hess, Matteo M. Bonsanto, Robert Huber, Heinz Handels, and Ralf Brinkmann,
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
DOI:10.1088/1361-6560/ac6d9d
Bibtex: BibTeX
@article{Strenge2022,
   author = {Strenge, P;Lange, B;Grill, C;Draxinger, W;Danicke, V;Theisen-Kunde, D;Hagel, C;Spahr-Hess, S;Bonsanto, Matteo M.;Huber, R;Handels, H and Brinkmann, R},
   title = {Registration of histological brain images onto optical coherence tomography images based on shape information},
keywords = {brain, glioblastoma multiforme, shape, OCT, optical coherence tomography, AG-Huber_OCT,},
   journal = {Physics in Medicine & Biology},
   ISSN = {0031-9155},
   url = {http://iopscience.iop.org/article/10.1088/1361-6560/ac6d9d},
   year = {2022},
   type = {Journal Article}
}
Clara Pfäffle, Hendrik Spahr, Katharina Gercke, Leo Puyo, Svea Höhl, David Melenberg, Yoko Miura, Gereon Hüttmann, and Dierck Hillmann,
Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer, Frontiers in Medicine , vol. 9, 06 2022.
DOI:10.3389/fmed.2022.885187
Datei: fmed.2022.885187
Bibtex: BibTeX
@article{RN5328,
   author = {Pfäffle, C;Spahr, H;Gercke, K;Puyo, L;Höhl, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer},
   journal = {Frontiers in Medicine},
   volume = {9},
   ISSN = {2296-858X},
   DOI = {10.3389/fmed.2022.885187},
keywords = {optoretinography, optical coherence tomography, phase-sensitive OCT, functional imaging, inner
plexiform layer, retina},
   url = {https://www.frontiersin.org/articles/10.3389/fmed.2022.885187},
   year = {2022},
   type = {Journal Article}
}
Aaron Doug Deen, Heleen van Beusekom, Tom Pfeiffer, Mathijs Stam, Dominique de Kleijn, Jolanda Wentzel, Robert Huber, Antonius F. W. van der Steen, Gijs van Soest, and Tianshi Wang,
Spectroscopic thermo-elastic optical coherence tomography for tissue characterization, Biomedical Optics Express , vol. 13(3), pp. 1430-1446, 02 2022.
DOI:10.1364/BOE.447911
Bibtex: BibTeX
@article{Deen2022,
   author = {Deen, A D;Van Beusekom, H M. M.;Pfeiffer, T;Stam, M;Kleijn, D De;Wentzel, J;Huber, R;Van Der Steen, A F. W.;Soest, G Van and Wang, T},
   title = {Spectroscopic thermo-elastic optical coherence tomography for tissue characterization},
   journal = {BioOptExpr},
keywords = {AG-Huber, Endoscopic imaging, Image processing, Image quality, Imaging techniques, Optical imaging, Tissue characterization},
   volume = {13(3)},
   pages = {1430-1446},
   DOI = {10.1364/BOE.447911},
    year = {2022},
   type = {Journal Article}
}
Madita Göb, Tom Pfeiffer, Wolfgang Draxinger, Simon Lotz, Jan Philip Kolb, and Robert Huber,
Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence, Biomed. Opt. Express , vol. 13, no. 2, pp. 713--727, 02 2022. OSA.
DOI:10.1364/BOE.448353
Bibtex: BibTeX
@article{Gob:22,
author = {Madita G\"{o}b and Tom Pfeiffer and Wolfgang Draxinger and Simon Lotz and Jan Philip Kolb and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {High speed imaging; Image processing; Image quality; In vivo imaging; Range imaging; Vertical cavity surface emitting lasers},
number = {2},
pages = {713--727},
publisher = {Optica Publishing Group},
title = {Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence},
volume = {13},
month = {Feb},
year = {2022},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-13-2-713},
doi = {10.1364/BOE.448353},
abstract = {We present continuous three-dimensional spectral zooming in live 4D-OCT using a home-built FDML based OCT system with 3.28 MHz A-scan rate. Improved coherence characteristics of the FDML laser allow for imaging ranges up to 10 cm. For the axial spectral zoom feature, we switch between high resolution and long imaging range by adjusting the sweep range of our laser. We present a new imaging setup allowing for synchronized adjustments of the imaging range and lateral field of view during live OCT imaging. For this, a novel inline recalibration algorithm was implemented that enables numerical k-linearization of the raw OCT fringes for every frame instead of every volume. This is realized by acquiring recalibration data within the dead time of the raster scan at the turning points of the fast axis scanner. We demonstrate in vivo OCT images of fingers and hands at different resolution modes and show real three-dimensional zooming during live 4D-OCT. A three-dimensional spectral zooming feature for live 4D-OCT is expected to be a useful tool for a wide range of biomedical, scientific and research applications, especially in OCT guided surgery.},
}
Konstantin Yashin, Matteo Mario Bonsanto, Ksenia Achkasova, Anna Zolotova, Al-Madhaji Wael, Elena Kiseleva, Alexander Moiseev, Igor Medyanik, Leonid Kravets, Robert Huber, Ralf Brinkmann, and Natalia Gladkova,
OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives, Diagnostics , vol. 12, no. 2, pp. 335, 01 2022.
DOI:10.3390/diagnostics12020335
Datei: 335
Bibtex: BibTeX
@article{Yashin-2022,
   author = {Yashin, K;Bonsanto, M M;Achkasova, K;Zolotova, A;Wael, Al-M;Kiseleva, E;Moiseev, A;Medyanik, I;Kravets, L;Huber, R;Brinkmann, R and Gladkova, N},
   title = {OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives},
   journal = {Diagnostics},
   volume = {12},
   number = {2},
   pages = {335},
   ISSN = {2075-4418},
keywords = {AG-Huber; optical coherence tomography; brain imaging; neurosurgical guidance; brain tumor; minimally invasive theranostics; intraoperative imaging},
   url = {https://www.mdpi.com/2075-4418/12/2/335},
   year = {2022},
   type = {Journal Article}
}
Birgit Lange, Tomasz Ozimek, Judith R. Wießmeyer, Mario W. Kramer, Axel S. Merseburger, and Ralf Brinkmann,
Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy, Biomedical Physics & Engineering Express , vol. 8, no. 5, pp. 055023, 2022.
DOI:10.1088/2057-1976/ac82c7
Bibtex: BibTeX
@article{Lange2022,
   author = {Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W.;Merseburger, A S. and Brinkmann, R},
   title = {Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy},
   journal = {Biomedical Physics & Engineering Express},
   volume = {8},
   number = {5},
abstract = {Objectives. In laser lithotripsy, a green aiming beam overlying the infrared (IR) treatment radiation gives rise to reflection and fluorescence signals that can be measured via the treatment fiber. While stone autofluorescence is used for target detection, the condition of the fiber can be assessed based on its Fresnel reflection. For good applicability, fluorescence detection of stones should work even when the stone and fiber are not in direct contact. Fiber breakage detection, on the other hand, can be falsified if surfaces located in front of the fiber reflect light from the aiming laser back into it. For both applications, therefore, a fundamental investigation of the dependence of the signal amplitude on the distance between fiber and surface is important. Methods. Calculations of the signal drop of fluorescence or diffuse and specular reflection with increasing fiber distance were performed using ray tracing based on a simple geometric model for different fiber core diameters. Reflection signals from a mirror, diffuse reflector, human calculi, and porcine renal tissue placed in water were measured at varying distances (0–5 mm). For human calculi, fluorescence signals were recorded simultaneously. Results. The calculations showed a linear signal decrease down to ∼60% of the maximum signal (fiber in contact). The distance z at which the signal drops to for example 50% depends linearly on the diameter of the fiber core. For fibers used in lithotripsy and positioned in water, z50% ranges from 0.55 mm (200 μm core diameter) to 2.73 mm, (1 mm core diameter). The calculations were in good agreement with the experimental results. Conclusions. The autofluorescence signals of stones can be measured in non-contact mode. Evaluating the Fresnel signal of the end face of the fiber to detect breakage is possible unless the fiber is situated less than some millimeters to reflecting surfaces.},
keywords = {urolithiasis, laser lithotripsy, fluorescence, reflectance},
   pages = {055023},
   ISSN = {2057-1976},
   DOI = {10.1088/2057-1976/ac82c7},
   
   year = {2022},
   type = {Journal Article}
}
Yoko Miura, Keiji Inagaki, Alessa Hutfilz, Eric Seifert, Benedikt Schmarbeck, Akira Murakami, Kishiko Ohkoshi, and Ralf Brinkmann,
Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application, Life , vol. 12(9), pp. 1313, 2022.
DOI:https://doi.org/10.3390/life12091313
Datei: 1313
Bibtex: BibTeX
@article{Miura2022,
   author = {Miura, Y;Inagaki, K;Hutfilz, A;Seifert, E;Schmarbeck, B;Murakami, A;Ohkoshi, K and Brinkmann, R},
   title = {Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application},
   journal = {Life},
   volume = {12(9)},
  
   pages = {1313},
   ISSN = {2075-1729},
   url = {https://www.mdpi.com/2075-1729/12/9/1313},
   year = {2022},
   type = {Journal Article}
}
Claus von der Burchard, Helge Sudkamp, Jan Tode, Christoph Ehlken, K. Purtskhvanidze, Moritz Moltmann, B. Heimes, Peter Koch, Michael Münst, Malte vom Endt, Timo Kepp, Dirk Theisen-Kunde, Inke R. König, Gereon Hüttmann, and Johann Roider,
Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study, BMJ Open , vol. 12, no. 6, pp. e055082, 2022.
DOI:10.1136/bmjopen-2021-055082
Datei: e055082.abstract
Bibtex: BibTeX
@article{von-der-Burchardt2022,
   author = {von der Burchard, C;Sudkamp, H;Tode, J;Ehlken, C;Purtskhvanidze, K;Moltmann, M;Heimes, B;Koch, P;Münst, M;vom Endt, M;Kepp, T;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J},
   title = {Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study},
   journal = {BMJ Open},
   volume = {12},
   number = {6},
   pages = {e055082},
   DOI = {10.1136/bmjopen-2021-055082},
   url = {http://bmjopen.bmj.com/content/12/6/e055082.abstract},
   year = {2022},
   type = {Journal Article}
}
X-X Liang, and A Vogel,
Probing neuronal functions with precise and targeted laser ablation in the living cortex: comment, Optica , vol. 9(8), pp. 868-871, 2022.
DOI:10.1364/OPTICA.454469
Bibtex: BibTeX
@article{Liang2022,
   author = {Liang, X-X and Vogel, A},
   title = {Probing neuronal functions with precise and targeted laser ablation in the living cortex: comment},
   journal = {Optica},
   volume = {9(8)},
   keywords = {Attenuation coefficient, Femtosecond lasers, Laser ablation, Laser irradiation, Numerical simulation, Thermal effects},
   pages = {868-871},
   DOI = {10.1364/OPTICA.454469},  
   year = {2022},
   type = {Journal Article}
}
Tianshi Wang, Tom Pfeiffer, Ali Akyildiz, Heleen M. M. Beusekom, Robert Huber, Antonius F. W. Steen, and Gijs Soest,
Intravascular optical coherence elastography, Biomed. Opt. Express , vol. 13, no. 10, pp. 5418--5433, 2022. Optica Publishing Group.
DOI:10.1364/BOE.470039
Datei: abstract.cfm
Bibtex: BibTeX
Optical coherence elastography (OCE), a functional extension of optical coherence tomography (OCT), visualizes tissue strain to deduce the tissue’s biomechanical properties. In this study, we demonstrate intravascular OCE using a 1.1 mm motorized catheter and a 1.6 MHz Fourier domain mode-locked OCT system. We induced an intraluminal pressure change by varying the infusion rate from the proximal end of the catheter. We analysed the pixel-matched phase change between two different frames to yield the radial strain. Imaging experiments were carried out in a phantom and in human coronary arteries in vitro. At an imaging speed of 3019 frames/s, we were able to capture the dynamic strain. Stiff inclusions in the phantom and calcification in atherosclerotic plaques are associated with low strain values and can be distinguished from the surrounding soft material, which exhibits elevated strain. For the first time, circumferential intravascular OCE images are provided side by side with conventional OCT images, simultaneously mapping both the tissue structure and stiffness.
Manuel A. Schaller, Mitsuru Wilson, Viktoria Kleymann, Mario Mordmüller, Ralf Brinkmann, Matthias A. Müller, and Karl Worthmann,
Parameter estimation and model reduction for model predictive control in retinal laser treatment, Control Engineering Practice , vol. 128, pp. 105320, 2022.
DOI:https://doi.org/10.1016/j.conengprac.2022.105320
Bibtex: BibTeX
@article{Schaller2022,
   author = {Schaller, M;Wilson, M;Kleyman, V;Mordmüller, M;Brinkmann, R;Müller, M. A. and Worthmann, K},
   title = {Parameter estimation and model reduction for model predictive control in retinal laser treatment},
   journal = {Control Engineering Practice},
   volume = {128},
   pages = {105320},
   ISSN = {0967-0661},
   DOI = {https://doi.org/10.1016/j.conengprac.2022.105320},

   year = {2022},
   type = {Journal Article}
}
S. Freidank, and N. Linz,
Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second, BioOptExpr , vol. 13 (5), pp. 3056-3079, 2022.
DOI:10.1364/BOE.455926
Bibtex: BibTeX
@article{Freidank2022,
   author = {Freidank, S;Vogel, A and Linz, N},
   title = {Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second},
   journal = {BioOptExpr},
   volume = {13 (5)},
   
   pages = {3056-3079},
   DOI = {10.1364/BOE.455926},

   year = {2022},
   type = {Journal Article}
}
Tabea Kohlfaerber, Mario Pieper, Michael Münter, Cornelia Holzhausen, Martin Ahrens, Christian Idel, Ludwig Bruchhage, Anke Leichtle, Peter König, Gereon Hüttmann, and Hinnerk Schulz-Hildebrandt,
Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways, Biomedical Optics Express , vol. 13 (6), pp. 3211-3223, 2022.
DOI:10.1364/BOE.456104
Bibtex: BibTeX
@article{Kohlfarber2022,
   author = {Kohlfaerber, T;Pieper, M;Münter, M;Holzhausen, C;Ahrens, M;Idel, C;Bruchhage, K-L;Leichtle, A;König, P;Hüttmann, G and Schulz-Hildebrandt, H},
   title = {Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways},
   journal = {Biomedical Optics Express},
   volume = {13 (6)},
   pages = {3211-3223},
   DOI = {10.1364/BOE.456104},
  
   year = {2022},
   type = {Journal Article}
}
P Musial, Tabea Kohlfaerber, Martin Ahrens, Hinnerk Schulz-Hildebrandt, Philipp Steven, and Gereon Hüttmann,
Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride, Translational Vision Science & Technology , vol. 11(5), pp. 28-28, 2022.
DOI:10.1167/tvst.11.5.28
Datei: tvst.11.5.28
Bibtex: BibTeX
@article{Musial-2022,
   author = {Musial, G;Kohlfaerber, T;Ahrens, M;Schulz-Hildebrandt, H;Steven, P and Hüttmann, G},
   title = {Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride},
   journal = {Translational Vision Science & Technology},
keywords = {toxicity; optical coherence tomography; benzalkonium chloride},
   volume = {11(5)},

   pages = {28-28},
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.11.5.28},
   url = {https://doi.org/10.1167/tvst.11.5.28},
   year = {2022},
   type = {Journal Article}
}
A. Thambyah M. Goodwin, and F. Vanholsbeeck,
Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography, Osteoarthritis and Cartilage , 2022.
DOI:https://doi.org/10.1016/j.joca.2022.04.006
Bibtex: BibTeX
@article{GOODWIN2022,
title = {Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography},
journal = {Osteoarthritis and Cartilage},
year = {2022},
issn = {1063-4584},
doi = {https://doi.org/10.1016/j.joca.2022.04.006},
author = {M. Goodwin, M. Klufts, J. Workman, A. Thambyah and F. Vanholsbeeck},
keywords = {Optical coherence tomography, Polarisation-sensitive optical coherence tomography, Osteoarthritis},
abstract = {Summary
Objective
To explore the ability of polarisation-sensitive optical coherence tomography (PS-OCT) to rapidly identify subtle signs of tissue degeneration in the equine joint.
Method
Polarisation-sensitive optical coherence tomography (PS-OCT) images were systematically acquired in four locations along the medial and lateral condyles of the third metacarpal bone in five dissected equine specimens. Intensity and retardation PS-OCT images, and anomalies observed therein, were then compared and validated with high resolution images of the tissue sections obtained using Differential Interference contrast (DIC) optical light microscopy.
Results
The PS-OCT system was capable of imaging the entire equine osteochondral unit, and allowed delineation of the three structurally differentiated zones of the joint, that is, the articular cartilage matrix, zone of calcified cartilage and underlying subchondral bone. Importantly, PS-OCT imaging was able to detect underlying matrix and bone changes not visible without dissection and/or microscopy.
Conclusion
PS-OCT has substantial potential to detect, non-invasively, sub-surface microstructural changes that are known to be associated with the early stages of joint tissue degeneration.}
}
x-x Liang, N. Linz, S. Freidank, G. Paltauf, and A Vogel,
Comprehensive analysis of spherical bubble oscillations and shock wave emission in laser-induced cavitation, Journal of Fluid Mechanics , vol. 940, pp. A5, 2022.
DOI:10.1017/jfm.2022.202
Bibtex: BibTeX
@article{Liang2022,
   author = {Liang, X-X;Linz, N;Freidank, S;Paltauf, G and Vogel, A},
   title = {Comprehensive analysis of spherical bubble oscillations and shock wave emission in laser-induced cavitation},
keywords = {bubble dynamics, cavitation, shock waves},
   journal = {Journal of Fluid Mechanics},
   volume = {940},
   pages = {A5},
   ISSN = {0022-1120},
   DOI = {10.1017/jfm.2022.202},
  
   year = {2022},
   type = {Journal Article}
}
Manuel A. Schaller, Viktoria Kleymann, Mario Mordmüller, Schmidt Christian, Mitsuru Wilson, Ralf Brinkmann, Matthias A. Müller, and Karl Worthmann,
Model predictive control for retinal laser treatment at 1 kHz, at - Automatisierungstechnik , vol. 70(11), pp. 992-1002, 2022.
Datei: auto-2022-0030
Bibtex: BibTeX
@article{Schaller2022,
   author = {Schaller, M.;Kleyman, K.;Mordmüller, M.;Schmidt, C.;Wilson, M.;Brinkmann, R.;Müller, M.A. and Worthmann, K.},
   title = {Model predictive control for retinal laser treatment at 1 kHz},
   journal = {at - Automatisierungstechnik},
   volume = {70(11)},
   keywords = {model predictive control; real-time control;retinal photocoagulation},
   pages = {992-1002},
  
   url = {https://doi.org/10.1515/auto-2022-0030},
   year = {2022},
   type = {Journal Article}
}

2021

Hubertus Hakert, Matthias Eibl, Marie Tillich, Ralph Pries, Gereon Hüttmann, Ralf Brinkmann, Barbara Wollenberg, Ludwig Bruchhage, Sebastian Karpf, and Robert Huber,
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
DOI:10.1364/OL.424726
Bibtex: BibTeX
@article{Hakert2021,
   author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber},
   title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1},
   journal = {Optics Letters},
   volume = {46(14)},
   number = {14},
   pages = {3456-3459},
keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering},
   DOI = {https://doi.org/10.1364/OL.424726},
   year = {2021},
   type = {Journal Article}
}
Tuula Peñate Medina, Jan Philip Kolb, Gereon Hüttmann, Robert Huber, Oula Peñate Medina, Naomi Larsen, Arianna Ferrari, Magdalena Rafecas, Mark Ellrichmann, Mariya S. Pravdivtseva, Mariia Anikeeva, Jana Humbert, Marcus Both, Jennifer Hundt, and Jan-Bernd Hövener,
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
DOI:10.3389/fimmu.2021.692222
Bibtex: BibTeX
@article{PenateMedina2021,
   author = {Peñate Medina, T;Kolb, J P;Hüttmann, G;Huber, R;Peñate Medina, O;Ha, L;Ulloa, P;Larsen, N;Ferrari, A;Rafecas, M;Ellrichmann, M;Pravdivtseva, M S.;Anikeeva, M;Humbert, J;Both, M;Hundt, J E. and Hövener, J-B},
   title = {Imaging Inflammation - From Whole Body Imaging to Cellular Resolution},
   journal = {Frontiers in immunology},
keywords = {AG-Huber, MRI, PET, SPECT, optical imaging, Optical coherence tomography (OCT), precision medicine, Two-Photon microscopy (TPM), hyperpolarization},
   volume = {12},
   pages = {692222-692222},
   ISSN = {1664-3224},
   DOI = {10.3389/fimmu.2021.692222},
   url = {https://pubmed.ncbi.nlm.nih.gov/34248987
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264453/},
   year = {2021},
   type = {Journal Article}
}
Thomas Gottschall, Tobias Meyer-Zedler, Michael Schmitt, Robert Huber, Jürgen Popp, Andreas Tünnermann, and Jens Limpert,
Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging, JRS , 06 2021.
DOI:10.1002/jrs.6171
Bibtex: BibTeX
@article{Gottschall2021,
   author = {T. Gottschall, T. Meyer-Zedler, M. Schmitt, R. Huber, J. Popp, A. Tünnermann and J. Limpert},
   title = {Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging},
   journal = {JRS},
  keywords = { AG-Huber_NL, coherent anti-Stokes Raman scattering microscopy, four-wave mixing, nonlinear
microscopy, ultrafast laser},
   ISSN = {0377-0486},   
   url = {https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jrs.6171},
   year = {2021},
   type = {Journal Article}
}
Simon Lotz, Christin Grill, Madita Göb, Wolfgang Draxinger, Jan Philip Kolb, and Robert Huber,
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
DOI:10.1364/BOE.422898
Bibtex: BibTeX
@article{Lotz2021,
   author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber},
   title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision},
   journal = {Biomedical Optics Express},
   volume = {12(5)},
   keywords={AG-Huber_FDML},
   pages = {2604-2616},
   url = {https://doi.org/10.1364/BOE.422898},
   year = {2021},
   type = {Journal Article}
}
Mark Schmidt, Christin Grill, Simon Lotz, Tom Pfeiffer, Robert Huber, and Christian Jirauschek,
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
DOI:10.1007/s00340-021-07600-1
Bibtex: BibTeX
@Article{Schmidt2021,
  author   = {M. Schmidt, C. Grill, S. Lotz, T. Pfeiffer, R. Hubert and C. Jirauschek},
  journal  = {Applied Physics B},
  title    = {Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime},
  year     = {2021},
  issn     = {1432-0649},
  number   = {5},
  pages    = {60},
  volume   = {127},
keywords={AG-Huber_FDML},
  abstract = {We report on the formation of various intensity pattern types in detuned Fourier domain mode-locked (FDML) lasers and identify the corresponding operating conditions. Such patterns are a result of the complex laser dynamics and serve as an ideal tool for the study of the underlying physical processes as well as for model verification. By numerical simulation we deduce that the formation of patterns is related to the spectral position of the instantaneous laser lineshape with respect to the transmission window of the swept bandpass filter. The spectral properties of the lineshape are determined by a long-term accumulation of phase-offsets, resulting in rapid high-amplitude intensity fluctuations in the time domain due to the narrow intra-cavity bandpass filter and the fast response time of the semiconductor optical amplifier gain medium. Furthermore, we present the distribution of the duration of dips in the intensity trace by running the laser in the regime in which dominantly dips form, and give insight into their evolution over a large number of roundtrips.},
  doi      = {10.1007/s00340-021-07600-1},
  refid    = {Schmidt2021},
}
Maximilian Büttner, Benjamin Luger, Wasim Abou Moulig, Bernd Junker, Carsten Framme, Christina Jacobson, Katharina Knoll, Amelie Pielen, SRT Study Group-Theisen-Kunde, Brinkmann, Miura,Birngruber, Ralf Brinkmann, Dirk Theisen-Kunde, and Yoko Miura,
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
DOI:10.1007/s00417-020-04999-9
Bibtex: BibTeX
@article{Büttner2021,
   author = {Büttner, M.;Luger, B.;Abou Moulig, W.;Junker, B.;Framme, C.;Jacobsen, C.;Knoll, K. and Pielen, A.; SRT Study Group(Brinkmann, R.; Miura, Y.)},
   title = {Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   volume = {259},
   number = {6},
   pages = {1401-1410},
   ISSN = {0721-832X (Print)
0721-832x},
   DOI = {10.1007/s00417-020-04999-9},
abstract = { PURPOSE: Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% within 6 months. In this study, the efficacy of selective retina therapy (SRT) was examined in patients with therapy refractory persistent acute CSC defined by symptoms for at least 6 months and persistent subretinal fluid (SRF) despite eplerenone therapy. MATERIAL AND METHODS: This is a prospective, monocentric observational study in 17 eyes (16 patients, mean age 42 years, 2 female). SRT was performed with the approved R:GEN laser (Lutronic, South Korea), a micropulsed 527-nm Nd:YLF laser device, with a train of 30 pulses of 1.7 μs at 100-Hz repetition rate at the point of focal leakage determined by fluorescein angiography (FA) at baseline (BSL). Visits on BSL, week 4 (wk4), and week 12 (wk12) included best corrected visual acuity (BCVA, logMar), central retinal thickness (CRT) on spectral domain optical coherence tomography (SD-OCT), and FA. Statistical analysis was performed by pair-by-pair comparisons of multiple observations in each case with Bonferroni correction for multiple testing. (IBM SPSS Statistics 25®). RESULTS: Mean CRT at BSL was 387.69 ± 110.4 μm. CRT significantly decreased by 106.31 μm in wk4 (95%-KI: 21.42-191.2; p = 0.01), by 133.63 μm in wk12 (95%-KI: 50.22-217.03; p = 0.001) and by 133.81 μm (95%-KI: 48.88-218.75; p = 0.001) compared to BSL. Treatment success defined as complete resolution of SRF occurred at wk4 in 7/17 eyes (35.3%) and at wk12 in 10/17 eyes (58.8%). Re-SRT was performed in 7/17 eyes (41.2%) after an average of 107.14 ± 96.59 days. Treatment success after Re-SRT was observed in 4/6 eyes (66.6%, 12 weeks after Re-SRT). Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. Notably, eyes with treatment success showed better BCVA at all timepoints and gained more letters compared to failures. CONCLUSION: Single or repetitive SRT may be an effective and safe treatment in 2 of 3 patients suffering from acute persistent CSC after 6 months of symptoms or more. We observed complete resolution of SRF in around 60% of eyes 12 weeks after first SRT treatment and also 12 weeks after Re-SRT treatment in eyes with persistent or recurrent SRF. Results on the long-term course after SRT are still pending.},
keywords = { Central serous chorioretinopathy; Fluorescein angiography; Micropulse laser; OCT; Persistent acute disease; Selective retina treatment; Subretinal fluid. },
   year = {2021},
   type = {Journal Article}
}
Michael Münter, Mario Pieper, Tabea Kohlfaerber, Ernst Bodenstorfer, Martin Ahrens, Christian Winter, Robert Huber, Peter König, Gereon Hüttmann, and Hinnerk Schulz-Hildebrandt,
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
DOI:10.1364/BOE.425001
Bibtex: BibTeX
@article{Münter2021,
   author = {M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann and H. Schulz-Hildebrandt},
   title = {Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast},
   journal = {BiomedOptE},
   volume = {12(10)},
   Keywords = {CMOS cameras,Full field optical coherence tomography,High numerical aperture optics, Image processing,In vivo imaging,Medical imaging,Ag-Huber},
   pages = {6024-6039},
   DOI = {10.1364/BOE.425001},
  
   year = {2021},
   type = {Journal Article}
}
Mario Mordmüller, Viktoria Kleymann, Manuel A. Schaller, Mitsuru Wilson, Dirk Theisen-Kunde, Karl Worthmann, Matthias A. Müller, and Ralf Brinkmann,
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Datei: aot-2021-0041
Bibtex: BibTeX
@article{Mordmüller-2021,
   author = {Mordmüller, M;Kleyman, V;Schaller, M;Wilson, M;Theisen-Kunde, D;Worthmann, K;Müller, M.A and Brinkmann, R},
   title = {Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate},
   journal = {Advanced Optical Technologies},
Keywords = {extended Kalman filter; laser-coagulation; model predictive control; ophthalmology; photo-acoustics},
  
   url = {https://doi.org/10.1515/aot-2021-0041},
   year = {2021},
   type = {Journal Article}
}
Elisabeth Richert, Julia Papenkort, Claus von der Burchard, Alexa Klettner, Patrik Arnold, Ralph Lucius, Ralf Brinkmann, Carsten Framme, Johann Roider, and Jan Tode,
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Datei: s12886-021-02188-8
Bibtex: BibTeX
@article{Richert2021,
   title        = {Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy},
   author       = {Richert, E;Papenkort, J;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Framme, C;Roider, J and Tode, J},
   year         = 2021,
   journal      = {BMC Ophthalmology},
   volume       = {21(1)},
   pages        = 412,
   issn         = {1471-2415},
   url          = {https://doi.org/10.1186/s12886-021-02188-8},
   keywords     = {Selective retina therapy (SRT), Thermal stimulation of the retina (TSR),  Age- related macular  degeneration (AMD), Regeneration, Rejuvenation},
   type         = {Journal Article}
}
Viktoria Kleymann, Manuel A. Schaller, Mitsuru Wilson, Mario Mordmüller, Ralf Brinkmann, Karl Worthmann, and Matthias A. Müller,
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
DOI:https://doi.org/10.1016/j.ifacol.2021.08.552
Datei: S2405896321013276
Bibtex: BibTeX
@article{Kleyman2021,
   author = {Kleyman, V;Schaller, M;Wilson, M;Mordmüller, M;Brinkmann, R;Worthmann, K and Müller, M.A.},
   title = {State and parameter estimation for model-based retinal laser treatment⁎⁎The collaborative project ”Temperature controlled retinal laser treatment” is funded by the German Research Foundation (DFG) under the project number 430154635 (MU 3929/3-1, WO 2056/7-1, BR 1349/6-1). MS was also funded by the DFG (grant WO 2056/2-1, project number 289034702). KW gratefully acknowledges funding by the German Research Foundation (DFG; grant WO 2056/6-1, project number 406141926)},
   journal = {IFAC-PapersOnLine},
   volume = {54(6)},
 
   pages = {244-250},
   ISSN = {2405-8963},
   DOI = {https://doi.org/10.1016/j.ifacol.2021.08.552},
   url = {https://www.sciencedirect.com/science/article/pii/S2405896321013276},
   year = {2021},
   type = {Journal Article}
}
A. Coker, and V. V. Yakovlev,
Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions, Photonics Research , vol. 9 (3), pp. 416-423, 2021.
DOI:10.1364/PRJ.411980
Bibtex: BibTeX
@article{Coker2021,
   author = {Coker, Z. N.;Liang, Xiao-Xuan;Kiester, A. S.;Noojin, G. D.;Bixler, J. N.;Ibey, B. L.;Vogel, A. and Yakovlev, V. V.},
   title = {Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions},
   journal = {Photonics Research},
   volume = {9 (3)},
   pages = {416-423},
   DOI = {10.1364/PRJ.411980},
 
   year = {2021},
   type = {Journal Article}
}
E. Seifert, Kleingarn Philipp, Svenja Sonntag, Dirk Theisen-Kunde, Salvatore Grisanti, Reginald Birngruber, Yoko Miura, and Ralf Brinkmann,
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
DOI:10.1167/iovs.62.3.32
Datei: iovs.62.3.32
Bibtex: BibTeX
@article{Seifert2021,
   author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R},
   title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {62(3)},
  
   pages = {32-32},
   ISSN = {1552-5783},
   DOI = {10.1167/iovs.62.3.32},
   url = {https://doi.org/10.1167/iovs.62.3.32},
   year = {2021},
   type = {Journal Article}
}
Sonja Jäckle, Tim Eixmann, Florian Matysiak, Malte Maria Sieren, Marco Horn, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, and Torben Pätz,
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
DOI:doi:10.1515/cdbme-2021-1004
Datei: cdbme-2021-1004
Bibtex: BibTeX
@article{Jaeckle2021c,
author = {J{\"{a}}ckle, Sonja and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and P{\"{a}}tz, Torben},
doi = {doi:10.1515/cdbme-2021-1004},
journal = {Current Directions in Biomedical Engineering},
year = {2021},
number = {1},
pages = {17--20},
title = {{3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair:}},
url = {https://doi.org/10.1515/cdbme-2021-1004},
volume = {7},
}
Sonja Jäckle, Annkristin Lange, Veronica Garcia-Vazquez, Tim Eixmann, Florian Matysiak, Malte Maria Sieren, Marco Horn, Gereon Hüttmann, Hinnerk Schulz-Hildebrandt, Floris Ernst, Stefan Heldmann, Torben Pätz, and Tobias Preusser,
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
DOI:10.1002/rcs.2327
Bibtex: BibTeX
@article{Jackle2021,
abstract = {Background: In endovascular aneuysm repair (EVAR) procedures, medical instruments are currently navigated with a two-dimensional imaging based guidance requiring X-rays and contrast agent. Methods: Novel approaches for obtaining the three-dimensional instrument positions are introduced. Firstly, a method based on fibre optical shape sensing, one electromagnetic sensor and a preoperative computed tomography (CT) scan is described. Secondly, an approach based on image processing using one 2D fluoroscopic image and a preoperative CT scan is introduced. Results: For the tracking based method, average errors from 1.81 to 3.13 mm and maximum errors from 3.21 to 5.46 mm were measured. For the image-based approach, average errors from 3.07 to 6.02 mm and maximum errors from 8.05 to 15.75 mm were measured. Conclusion: The tracking based method is promising for usage in EVAR procedures. For the image-based approach are applications in smaller vessels more suitable, since its errors increase with the vessel diameter.},
author = {J{\"{a}}ckle, Sonja and Lange, Annkristin and Garcia-Vazquez, Veronica and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and Ernst, Floris and Heldmann, Stefan and P{\"{a}}tz, Torben and Preusser, Tobias},
doi = {10.1002/rcs.2327},
file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Medical Robotics and Computer Assisted Surgery/J{\"{a}}ckle et al. - 2021 - Instrument localisation for endovascular aneurysm repair Comparison of two methods based on tracking systems or.pdf:pdf},
issn = {1478596X},
journal = {International Journal of Medical Robotics and Computer Assisted Surgery},
keywords = {2D/3D registration,3D localisation,computer-assisted surgery,electromagnetic tracking system,endovascular procedures,fibre optical shape sensing},
number = {6},
pages = {e2327},
year = {2021},
title = {{Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging}},
volume = {17}
}
Michelle Prasuhn, Yoko Miura, Aysegül Tura, Felix Rommel, Vinodh Kakkassery, Svenja Sonntag, Salvatore Grisanti, and Mahdy Ranjbar,
Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study, J ClinMed , vol. 10(11), pp. 2418, 2021.
DOI:10.3390/jcm10112418
Datei: 2418
Bibtex: BibTeX
@article{Prasuhn2021,
   author = {Prasuhn, M;Miura, Y;Tura, A.;Rommel, Felix;Kakkassery, V;Sonntag, S;Grisanti, S and Ranjbar, M},
   title = {Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study},
   journal = {J ClinMed},
   volume = {10(11)},
   
   pages = {2418},
   ISSN = {2077-0383},
   url = {https://www.mdpi.com/2077-0383/10/11/2418},
   year = {2021},
   type = {Journal Article}
}
Yoko Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO, Nippon Laser Igakkaishi , vol. advpub, 2021.
DOI:10.2530/jslsm.jslsm-42_0008
Bibtex: BibTeX
@article{Miura-3,
   author = {Miura, Y},
   title = {Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO},
   journal = {Nippon Laser Igakkaishi},
   volume = {advpub},
   DOI = {10.2530/jslsm.jslsm-42_0008},
   year = {2021},
   type = {Journal Article}
}
Svenja Sonntag, Eric Seifert, Maximilian Hamann, Britta Lewke, Dirk Theisen-Kunde, Salvatore Grisanti, Ralf Brinkmann, and Yoko Miura,
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
DOI:https://www.mdpi.com/2075-1729/11/6/555
Datei: 555
Bibtex: BibTeX
@article{Miura2021-2,
   author = {Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y},
   title = {Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States},
   journal = {Life},
   volume = {11(6)},
  keywords = {retinal laser treatment; metabolic change; fluorescence lifetime imaging ophthalmoscopy},
   pages = {555},
   ISSN = {2075-1729},
   url = {https://www.mdpi.com/2075-1729/11/6/555},
   year = {2021},
   type = {Journal Article}
}
Akika Kyo, Manabu Yamamoto, Kumiko Hirayama, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, and Shigeru Honda,
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
DOI:10.1038/s41598-021-88372-8
Bibtex: BibTeX
@article{Kyo-2021,
   author = {Kyo, A.;Yamamoto, M.;Hirayama, K.;Kohno, T.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.},
   title = {Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy},
   journal = {Sci Rep},
   volume = {11(1)},
  
   pages = {8973},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-021-88372-8},
   year = {2021},
   type = {Journal Article}
}
Christian Burri, Alessa Hutfilz, Lorenz Grimm, Simon Salzmann, Patrik Arnold, Boris Považay, Christoph Meier, Andreas Ebneter, Dirk Theisen-Kunde, and Ralf Brinkmann,
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
DOI:https://doi.org/10.3390/app11125535
Datei: 5535
Bibtex: BibTeX
@article{Burri2021,
   author = {Burri, C;Hutfilz, A;Grimm, L;Salzmann, S;Arnold, P;Považay, B;Meier, C;Ebneter, A;Theisen-Kunde, D and Brinkmann, R},
   title = {Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery},
   journal = {Applied Sciences},
   volume = {11(12)},
   
   pages = {5535},
   ISSN = {2076-3417},
   DOI = { https://doi.org/10.3390/app11125535},
   url = {https://www.mdpi.com/2076-3417/11/12/5535},
   year = {2021},
keywords = {selective retina therapy; viability assay; photocoagulation; microbubble formation;
thermomechanical damage; fringe washout; coherence-loss},
   type = {Journal Article}
}
Matteo Guiseppe Cereda, Y.G.M. Douven, Koorosh Faridpooya, Gereon Hüttmann, Tim Eixmann, Hinnerk Schulz-Hildebrandt, Gernot Kronreif, Saskia van Romunde, Maarten Beelen, and M D. de Smet,
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
DOI:https://doi.org/10.1016/j.xops.2021.100085
Bibtex: BibTeX
@article{Cereda-2021,
   author = {Cereda, M G;Parrulli, S;Douven, Y. G. M.;Faridpooya, K;van Romunde, S;Hüttmann, G;Eixmann, T;Schulz-Hildebrandt, H;Kronreif, G;Beelen, M and de Smet, M D.},
   title = {Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery},
   journal = {Ophthalmology Science},
   volume = {1(4)},
  
   pages = {100085},
   ISSN = {2666-9145},
   DOI = {https://doi.org/10.1016/j.xops.2021.100085},
  
   year = {2021},
   type = {Journal Article}
}
Eric Seifert, Jan Tode, Amelie Pielen, Dirk Theisen-Kunde, Carsten Framme, Johann Roider, Yoko Miura, Reginald Birngruber, and Ralf Brinkmann,
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Datei: S2213597921000756
Bibtex: BibTeX
@article{Seifert2021,
   author = {Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R},
   title = {Algorithms for optoacoustically controlled selective retina therapy (SRT)},
   journal = {Photoacoustics},
Keywords = {SRT; Lasers in medicine; Ophthalmology; RPE; Selectivity; Algorithm; Retina therapy; Optoacoustics; Feedback},
   volume = {25},
   pages = {100316},
   ISSN = {2213-5979},
   url = {https://www.sciencedirect.com/science/article/pii/S2213597921000756},
   year = {2021},
   type = {Journal Article}
}
R Schenk, and S Kassumeh,
Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography, Tvst , vol. 10 (13), pp. 22-22, 2021.
DOI:10.1167/tvst.10.13.22
Bibtex: BibTeX
@article{Schenk-2021,
   author = {Schenk, M S;Wartak, A;Buehler, V;Zhao, J;Tearney, G J;Birngruber, R and Kassumeh, S},
   title = {Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography},
   journal = {Tvst},
keywords = {corneal nerves; micro–optical coherence tomography; subbasal plexus},
   volume = {10 (13)},
   pages = {22-22},
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.10.13.22},

   year = {2021},
   type = {Journal Article}
}

2020

Claus von der Burchard, Moritz Moltmann, Jan Tode, Christoph Ehlken, Helge Sudkamp, Dirk Theisen-Kunde, Inke R. König, Gereon Hüttmann, and Johann Roider,
Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases, Graefe's Archive for Clinical and Experimental Ophthalmology , Dez. 2020.
Datei: s00417-020-05035-6
Bibtex: BibTeX
@article{von-derBurchard2020,
   author = {von der Burchard, C;Moltmann, M.;Tode, J;Ehlken, C;Sudkamp, H;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J},
   title = {Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   ISSN = {1435-702X},
   
   url = {https://doi.org/10.1007/s00417-020-05035-6},
   year = {2020},
   type = {Journal Article}
}
Tom Pfeiffer, Madita Göb, Wolfgang Draxinger, Sebastian Karpf, Jan Philip Kolb, and Robert Huber,
Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging, Biomed. Opt. Express , vol. 11, no. 11, pp. 6799--6811, Nov. 2020. OSA.
DOI:10.1364/BOE.402477
Bibtex: BibTeX
@article{Pfeiffer:20,
author = {T. Pfeiffer, M. G\"{o}b, W. Draxinger, S. Karpf, J.P. Kolb and R. Huber},
journal = {Biomed. Opt. Express},
keywords = {AG-Huber_OCT; High speed imaging; Image quality; Optical coherence tomography; Swept lasers; Swept sources; Systems design},
number = {11},
pages = {6799--6811},
publisher = {OSA},
title = {Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging},
volume = {11},
month = {Nov},
year = {2020},
doi = {10.1364/BOE.402477},
abstract = {In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze them point by point and describe the appropriate solutions. We prove that coherent averaging is possible at MHz OCT-speed without special interferometer designs or digital phase stabilization. We find, that in our system up to \&\#x223C;100x coherent averaging is possible while achieving a sensitivity increase close to the ideal values. This corresponds to a speed reduction from 3.3 MHz to 33 kHz and a sensitivity gain of 20 dB. We show an imaging comparison between coherent and magnitude averaging of a human finger knuckle joint in vivo with 121\&\#x00A0;dB sensitivity for the coherent case. Further, the benefits of computational downscaling in low sensitivity MHz-OCT systems are analyzed.},
}
Elisabeth Richert, Claus von der Burchard, Alexa Klettner, Patrik Arnold, Ralph Lucius, Ralf Brinkmann, Johann Roider, and Jan Tode,
Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models, 09 2020.
Datei: S2590153220300112
Bibtex: BibTeX
@article{RN5351,
   author = {Richert, E;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Roider, J and Tode, J},
   title = {Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models},
   journal = {Cytokine: X},
   volume = {2},
   number = {3},
   pages = {100031},
   ISSN = {2590-1532},
   DOI = {https://doi.org/10.1016/j.cytox.2020.100031},
   url = {https://www.sciencedirect.com/science/article/pii/S2590153220300112},
   year = {2020},
   type = {Journal Article}
}
Mark Schmidt, Tom Pfeiffer, Christin Grill, Robert Huber, and Christian Jirauschek,
Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2020. Optical Society of America.
DOI:10.1364/OSAC.389972
Bibtex: BibTeX
@article{schmidt2020self,
  title={Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers},
  author={M. {Schmidt}, T. {Pfeiffer}, C. {Grill}, R. {Huber} and C. {Jirauschek}},
  journal={OSA Continuum},
  volume={3},
  number={6},
  pages={1589--1607},
  year={2020},
keywords={AG-Huber_FDML},
url={https://doi.org/10.1364/OSAC.389972}, 
  publisher=  {Optical Society of America}
}
Leonardo Cecchetti, Tianshi Wang, Ayla Hoogendoorn, Karen T. Witberg, Jurgen M. R. Lighthart, Joost Daemen, Heleen van Beusekom, Tom Pfeiffer, Robert Huber, Jolanda Wentzel, Antonius F. W. van der Steen, and Gijs van Soest,
In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT, The International Journal of Cardiovascular Imaging , vol. 36, no. 6, pp. 1021-1029, 02 2020. Springer Science and Business Media LLC.
DOI:10.1007/s10554-020-01796-7
Bibtex: BibTeX
@article{Cecchetti2020,
  doi = {10.1007/s10554-020-01796-7},
  url = {https://doi.org/10.1007/s10554-020-01796-7},
  year = {2020},
  month = feb,
  publisher = {Springer Science and Business Media {LLC}},
  volume = {36},
  number = {6},
  pages = {1021--1029},
  author = {Leonardo Cecchetti and Tianshi Wang and Ayla Hoogendoorn and Karen T. Witberg and Jurgen M. R. Ligthart and Joost Daemen and Heleen M. M. van Beusekom and Tom Pfeiffer and Robert A. Huber and Jolanda J. Wentzel and Antonius F. W. van der Steen and Gijs van Soest},
  title = {In-vitro and in-vivo imaging of coronary artery stents with Heartbeat {OCT}},
  journal = {The International Journal of Cardiovascular Imaging}
}
Sonja Jäckle, Veronica Garcia-Vazquez, Tim Eixmann, Florian Matysiak, Felix von Haxthausen, Malte Maria Sieren, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, Floris Ernst, Markus Kleemann, and Torben Pätz,
Three-dimensional guidance including shape sensing of a stentgraft system for endovascular aneurysm repair, Int J Comp Assis Radiology and Surgery , 2020.
ISBN:1861-6429
Datei: s11548-020-02167-2
Bibtex: BibTeX
@article{jackle2020,
title = {Three-dimensional guidance including shape sensing of a stentgraft system for endovascular aneurysm repair},
author = {Jäckle,S; Garcia-Vazquez,V; Eixmann, T; Matysiak, F; von Haxthausen,F; Sieren; M m; Schulz-Hildebrandt, H;  H\"{u}ttmann, G; Ernst, F; Kleemann, M and P\"{a}tz, T},
url = {https://doi.org/10.1007/s11548-020-02167-2},

isbn = {1861-6429},
year = {2020},
date = {2020-04-06},
journal = {Int J  Comp Assis Radiology and Surgery},
abstract = {During endovascular aneurysm repair (EVAR) procedures, medical instruments are guided with two-dimensional (2D) fluoroscopy and conventional digital subtraction angiography. However, this requires X-ray exposure and contrast agent is used, and the depth information is missing. To overcome these drawbacks, a three-dimensional (3D) guidance approach based on tracking systems is introduced and evaluated.},
keywords = {HSH},
pubstate = {published},
tppubtype = {article}
}
Jalali,
Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates, Nature Communications , vol. 11(1), pp. 2062, 2020.
Datei: s41467-020-15618-w
Bibtex: BibTeX
@article{Karpf-2020,
   author = {S. Karpf, C.T. Riche, D. Di Carlo, A. Goel, W.A. Zeiger, A. Suresh, C. Portera-Cailliau B. and Jalali},
   title = {Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates},
   journal = {Nature Communications},
   volume = {11(1)},
  keywords={},
   pages = {2062},
   ISSN = {2041-1723},
  
   url = {https://doi.org/10.1038/s41467-020-15618-w},
   year = {2020},
   type = {Journal Article}
}
J A. Kilin, and J-P Wolf,
Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles, ACS Nano , vol. 14(4), pp. 4087-4095, 2020.
Datei: acsnano.9b08813
Bibtex: BibTeX
@article{Vogel-2020,
   author = {Kilin, V;Campargue, G;Fureraj, I;Sakong, S;Sabri, T;Riporto, F;Vieren, A;Mugnier, Y;Mas, C;Staedler, D;Collins, J M;Bonacina, L;Vogel, A;Capobianco, J A. and Wolf, J-P},
   title = {Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles},
   journal = {ACS Nano},
   volume = {14(4)},
   
   pages = {4087-4095},
   ISSN = {1936-0851},
   
   url = {https://doi.org/10.1021/acsnano.9b08813},
   year = {2020},
   type = {Journal Article}
}
Manabu Yamamoto, Yoko Miura, Akika Kyo, Kumiko Hirayama, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, and Shigeru Honda,
Selective retina therapy for subretinal fluid associated with choroidal nevus, Amer J Ophthalm Case Rep , vol. 19, pp. 100794, 2020.
DOI:https://doi.org/10.1016/j.ajoc.2020.100794
Bibtex: BibTeX
@article{yamamoto2020,
   author = {Yamamoto, M;Miura, Y;Kyo, A;Hirayama, K;Kohno, T;Theisen-Kunde, D;Brinkmann, R and Honda, S},
   title = {Selective retina therapy for subretinal fluid associated with choroidal nevus},
   journal = {Amer J Ophthalm Case Rep},
   volume = {19},
   pages = {100794},
   ISSN = {2451-9936},
keywords = {Laser therapy, Choroidal tumor, Retinal pigment epithelium, Retinal disorder},
   DOI = {https://doi.org/10.1016/j.ajoc.2020.100794},
   
   year = {2020},
   type = {Journal Article}
}
Kumiko Hirayama, Manabu Yamamoto, Takeya Kohno, Akika Kyo, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, and Shigeru Honda,
Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome, Graefes Arch Clin Exp Ophthalmol , vol. 259, pp. 387-393, 2020.
DOI:10.1007/s00417-020-04931-1
Bibtex: BibTeX
@article{Hirayama2020,
   author = {Hirayama, K.;Yamamoto, M.;Kohno, T.;Kyo, A.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.},
   title = {Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   ISSN = {0721-832x},
 volume = {259},
   pages = {387-393},
   DOI = {10.1007/s00417-020-04931-1},
   year = {2020},
   type = {Journal Article}
}
Elisabeth Richert, Julia Papenkort, Alexa Klettner, Jan Tode, Stefan Koinzer, Ralf Brinkmann, Christine Fink, Thomas Roeder, Ralph Lucius, and Johann Roider,
Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR), Lasers in Surgery and Medicine , 2020.
DOI:DOI 10.1002/lsm.23288
Bibtex: BibTeX
@article{Richert2020,
   author = {Richert, E;Papenkort, J;Klettner, A;Tode, J;Koinzer, S;Brinkmann, R;Fink, C;Roeder, T;Lucius, R. and Roider, J},
   title = {Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)},
   journal = {Lasers in Surgery and Medicine},
Keywords = {age‐related macular degeneration; thermal stimulation therapy of the retinal pigment epithelium;
matrix metalloproteases; pigment epithelium derived factor; retinal pigment epithelium; vascular endothelial
growth factor; transforming growth factor‐β},
   DOI = {DOI 10.1002/lsm.23288},
   year = {2020},
   type = {Journal Article}
}
Paula Enzian, Christian Schell, Astrid Link, Carina Malich, Ralph Pries, Barbara Wollenberg, and Ramtin Rahmanzadeh,
Optically controlled drug release from light-sensitive liposomes with the new photosensitizer 5,10-DiOH, Molecular Pharmaceutics , 2020.
DOI:10.1021/acs.molpharmaceut.9b01173
Bibtex: BibTeX
@article{Enzian2020,
   author = {Enzian, P.;Schell, C.;Link, A.;Malich, C.;Pries, R.;Wollenberg, B and Rahmanzadeh, R},
   title = {Optically controlled drug release from light-sensitive liposomes with the new photosensitizer 5,10-DiOH},
   journal = {Molecular Pharmaceutics},
   ISSN = {1543-8384},
   DOI = {10.1021/acs.molpharmaceut.9b01173},
   
   year = {2020},
   type = {Journal Article}
}
R R Wertheimer,
Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia, J Refractive Surg , no. 6(36), pp. 406--413, 2020.
Datei: refractive-changes-after-corneal-stromal-filler-injection-for-the-correction-of-hyperopia
Bibtex: BibTeX
@article{Wertheimer2020,
author = {Wertheimer, C M; Brandt, K; Kaminsky, S; Elhardt, C; Kassumeh, S A; Pham, L; Schulz-Hildebrandt, H; Priglinger, S; Anderson, R R and Birngruber, R},

url = {https://www.healio.com/ophthalmology/journals/jrs/2020-6-36-6/%7B8e6aaf40-922c-4998-9c7b-39b47135ec61%7D/refractive-changes-after-corneal-stromal-filler-injection-for-the-correction-of-hyperopia},
journal = {J Refractive Surg},
number = {6(36)},
pages = {406--413},
title = {Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia},

date = {2020-06-14},
year = {2020},
keywords ={mOCT, HSH}
}
Manabu Yamamoto, Yoko Miura, Kumiko Hirayama, Takeya Kohno, Daijiro Kabata, Dirk Theisen-Kunde, Ralf Brinkmann, and Shigeru Honda,
Predictive factors of outcome of selective retina therapy for diabetic macular edema, International Ophthalmology , 2020.
Datei: s10792-020-01288-6
Bibtex: BibTeX
@article{Miura2020-2,
   author = {Yamamoto, M;Miura, Y;Hirayama, K;;Kohno, T;Kabata, D;Theisen-Kunde, D;Brinkmann, R and Honda, S;},
   title = {Predictive factors of outcome of selective retina therapy for diabetic macular edema},
   journal = {International Ophthalmology},
   ISSN = {1573-2630},
   
   url = {https://doi.org/10.1007/s10792-020-01288-6},
   year = {2020},
   type = {Journal Article}
}
Matthias Müller, Ramtin Rahmanzadeh, Thao Tran, Jan Kappelhoff, Eman Aburieda Akam, Peter Caravan, Thomas Jüstel, Kathryn D Held, R.Rox Anderson, and Martin Purschke,
Particle size of X-ray pumped UVC emitting nanoparticles defines intracellular localization and biological activity against cancer cells, Particle and Particle Systems Characterization , 2020.
DOI:10.1002/ppsc.202000201
Datei: 0
Bibtex: BibTeX
@article{Müller2020,
   author = {Müller M;Rahmanzadeh R;Tran T;Kappelhoff J;Akam EA;Caravan P;Jüstel T;Held KD;Anderson R and M, and Purschke},
   title = {Particle size of X-ray pumped UVC emitting nanoparticles defines intracellular localization and biological activity against cancer cells},
   journal = {Particle and Particle Systems Characterization },
   year = {2020},
   type = {Journal Article},
url = { https://onlinelibrary.wiley.com/toc/15214117/0/0}
}
G J. Elhardt,
Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography, Translational Vision Science & Technology , vol. 9(5), pp. 6-6, 2020.
Datei: tvst.9.5.6
Bibtex: BibTeX
@article{Birngruber2020,
   author = {Elhardt, C;Wertheimer, C M.;Wartak, A;Zhao, J;Leung, H M;Kassumeh, S A.;Yin, B;Tearney, G J. and Birngruber, R},
   title = {Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography},
   journal = {Translational Vision Science & Technology},
   volume = {9(5)},
  
   pages = {6-6},
   ISSN = {2164-2591},
   Keywords = {optical coherence tomography; micro-OCT; imaging;corneal nerves; diabetes},
   url = {https://doi.org/10.1167/tvst.9.5.6},
   year = {2020},
   type = {Journal Article}
}
R Wartak, and G J. Tearney,
Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures, Biomedical Optics Express , vol. 11(10), pp. 5920-5933, 2020.
DOI: https://doi.org/10.1364/BOE.402971
Bibtex: BibTeX
@article{Wartak2020,
   author = {Wartak, A;Schenk, M S.;Bühler, V;Kassumeh, S A.;Birngruber, R and Tearney, G J.},
   title = {Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures},
keywords = {High numerical aperture optics,Image metrics,Image processing,Image quality,Optical coherence tomography,Optical imaging},
   journal = {Biomedical Optics Express},
   volume = {11(10)},
  
DOI = { https://doi.org/10.1364/BOE.402971},
   pages = {5920-5933},
   
   year = { 2020},
   type = {Journal Article}
}
S. Freidank, and N. Linz,
Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery, TVST , vol. 9(10), pp. 22-22, 2020.
Datei: tvst.9.10.22
Bibtex: BibTeX
@article{Freidank2020,
   author = {Freidank, S;Vogel, A and Linz, N},
   title = {Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery},
   journal = {TVST},
   volume = {9(10)},
   
   pages = {22-22},
   ISSN = {2164-2591},
 
   url = {https://doi.org/10.1167/tvst.9.10.22},
   year = {2020},
   type = {Journal Article}
}
Asylkhan E. Rakhymzhan, Lucie Reuter, Raphael Raspe, Daniel Bremer, Judith Heidelin, Volker Andresen, Robert Günther, Ruth Leben, Sergey Cheremukhin, Hinnerk Schulz-Hildebrandt, Maria G. Bixel, Ralf H. Adams, Helena Radbruch, Gereon Hüttmann, Anja E. Hauser, and Raluca A. Niesner,
Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging, Cytometry Part A , vol. 97, no. 5, pp. 515-527, 2020.
DOI:10.1002/cyto.a.24012
Bibtex: BibTeX
@article{Schulz-Hildebrandt-2020,
   author = {Rakhymzhan, A;Reuter, L;Raspe, R;Bremer, D;Günther, R;Leben, R;Heidelin, J;Andresen, V;Cheremukhin, S;Schulz-Hildebrandt, H;Bixel, M G.;Adams, R H.;Radbruch, H;Hüttmann, G;Hauser, A E. and Niesner, R A.},
   title = {Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging},
  year = {2020},
   journal = {Cytometry Part A},
   volume = {97},
   number = {5},
   pages={515-527},
   ISSN = {1552-4922},
   DOI = {10.1002/cyto.a.24012},
   type = {Journal Article}
}
M Palczewska, and K Palczewski,
Noninvasive two-photon optical biopsy of retinal fluorophores, Proceedings of the National Academy of Sciences , pp. 202007527, 2020.
DOI:10.1073/pnas.2007527117
Bibtex: BibTeX
@article{Palczewska-2020,
   title        = {Noninvasive two-photon optical biopsy of retinal fluorophores},
   author       = {Palczewska, G;Boguslawski, J;Stremplewski, P;Kornaszewski, L;Zhang, J;Dong, Z;Liang, Xiao-Xuan;Gratton, E;Vogel, A;Wojtkowski, M and Palczewski, K},
   year         = 2020,
   journal      = {Proceedings of the National Academy of Sciences},
   pages        = 202007527,
   doi          = {10.1073/pnas.2007527117},
   type         = {Journal Article}
}
Hartmut Schneider, Martin Ahrens, Michaela Strumpski, Claudia Rüger, Matthias Häfer, Gereon Hüttmann, Dirk Theisen-Kunde, Hinnerk Schulz-Hildebrandt, and Rainer Haak,
An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations, J Clin Med , vol. 9(10), 2020.
DOI:10.3390/jcm9103257
Bibtex: BibTeX
@article{schneider2020,
   author = {Schneider, H.;Ahrens, M.;Strumpski, M.;Ruger, C.;Hafer, M.;Huettmann, G.;Theisen-Kunde, D.;Schulz-Hildebrandt, H. and Haak, R.},
   title = {An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations},
   journal = {J Clin Med},
   volume = {9(10)},
   keywords = {OCT; intraoral probe; carious lesions; caries diagnosis; dental restorations},
   ISSN = {2077-0383 (Print)
2077-0383 (Linking)},
   DOI = {10.3390/jcm9103257},
   
   year = {2020},
   type = {Journal Article}
}
N Koop,
Beständig durch Mikrodefekte, Pharma+Food , 2020.
Datei:
Bibtex: BibTeX
@article{Koop2020,
   author = {Koop, N},
   title = {Beständig durch Mikrodefekte},
   journal = {Pharma+Food},
   url = { https://www.pharma-food.de/bestaendig-durch-mikrodefekte/},
   year = {2020},
   type = {Journal Article}
}
Cuiping Yao, Florian Rudnitzki, Yida He, Zhenxi Zhang, Gereon Hüttmann, and Ramtin Rahmanzadeh,
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
DOI:10.1002/jbio.202000017
Bibtex: BibTeX
@article{Rahmanzadeh-2020,
   author = {Yao, C;Rudnitzki, F;He, Y;Zhang, Z;Hüttmann, G and Rahmanzadeh, R},
   title = {Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods},
   journal = {JBio},
   
   ISSN = {1864-063X},
   DOI = {10.1002/jbio.202000017},
  Year = {2020},
   type = {Journal Article}
}
Markus Luecking, Ralf Brinkmann, Scarlett Ramos, Wilhelm Stork, and Nico Heussner,
Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage, CompBioMed , vol. 122, pp. 103835, 2020.
DOI:https://doi.org/10.1016/j.compbiomed.2020.103835
Bibtex: BibTeX
@article{brinkmann2020-2,
   author = {Luecking, M;Brinkmann, R;Ramos, Sc;Stork, W and Heussner, N},
   title = {Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage},
   journal = {CompBioMed},
   volume = {122},
   pages = {103835},
   ISSN = {0010-4825},
   DOI = {https://doi.org/10.1016/j.compbiomed.2020.103835},
 
   year = {2020},
   type = {Journal Article}
}
R. R. Kassumeh,
Corneal Stromal Filler Injection as a Novel Approach to Correct Presbyopia—An Ex Vivo Pilot Study, TVST , vol. 9(7), pp. 30-30, 2020.
Datei: tvst.9.7.30
Bibtex: BibTeX
@article{Kassumeh2020,
   author = {Kassumeh, S;Luther, J K.;Wertheimer, C M.;Brandt, K;Schenk, M S.;Priglinger, S G.;Wartak, A;Apiou-Sbirlea, G.;Anderson, R. R. and Birngruber, R},
   title = {Corneal Stromal Filler Injection as a Novel Approach to Correct Presbyopia—An Ex Vivo Pilot Study},
   journal = {TVST},
   volume = {9(7)},
  keywords = { presbyopia correction; corneal filler; refractive surgery; femtosecond laser; hyaluronic acid; bifocality},

   pages = {30-30},
   ISSN = {2164-2591},
   
   url = {https://doi.org/10.1167/tvst.9.7.30},
   year = {2020},
   type = {Journal Article}
}
Vasily Matkivsky, Alexander Moiseev, Pavel Shilyagin, Alexander Rodionov, Hendrik Spahr, Clara Pfäffle, Gereon Hüttmann, Dierck Hillmann, and Grigory Gelikonov,
Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function, Journal of Biophotonics , vol. 13(10), pp. e202000112, 2020.
DOI:10.1002/jbio.202000112
Bibtex: BibTeX
@article{Matkivsky2020,
   author = {Matkivsky, V;Moiseev, A;Shilyagin, P;Rodionov, A;Spahr, H;Pfäffle, C;Hüttmann, G;Hillmann, D and Gelikonov, G},
   title = {Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function},
   journal = {Journal of Biophotonics},
   volume = {13(10)},
   pages = {e202000112},
   ISSN = {1864-063X},
   DOI = {10.1002/jbio.202000112},
   year = {2020},
   type = {Journal Article}
}
A Holzhey, and Mahdy Ranjbar,
Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss, Journal of visualized experiments: JoVE , no. 158, 2020.
DOI:10.3791/60542
Bibtex: BibTeX
@article{Holzhey2020,
   author = {Holzhey, A;Sonntag, S;Rendenbach, J;Ernesti, J S;Kakkassery, V;Grisanti, S;Reinholz, F;Freidank, S;Vogel, A and Ranjbar, M},
   title = {Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss},
   journal = {Journal of visualized experiments: JoVE},
   number = {158},
   ISSN = {1940-087X},
DOI = {10.3791/60542 },
   year = {2020},
   type = {Journal Article}
}
Michael Münter, Mario Pieper, Malte Casper, Martin Ahrens, Tabea Kohlfaerber, Ramtin Rahmanzadeh, Peter König, Gereon Hüttmann, and Hinnerk Schulz-Hildebrandt,
Dynamic contrast in scanning microscopic OCT, Optic Letters , 2020.
Datei: 2003.00006
Bibtex: BibTeX
@article{Münter2020,
   author = {Münter, M;Endt, M v;Pieper, M;Casper, M;Ahrens, M;Kohlfaerber, T;Rahmanzadeh, R;König, P;Hüttmann, G and Schulz-Hildebrandt, H},
   title = {Dynamic contrast in scanning microscopic OCT},
   journal = {Optic Letters},
url = {https://arxiv.org/abs/2003.00006},
   year = {2020},
   type = {Journal Article}
}
Elisabeth Richert, Sofya Bartsch, Jost Hillenkamp, Felix Treumer, Jan Tode, Claus von der Burchard, Ralf Brinkmann, Alexa Klettner, and Johann Roider,
Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums, Klin Monatsbl Augenheilkd , vol. 237(02), pp. 192-201, 2020.
DOI:10.1055/a-0838-5633
Datei: a-0838-5633
Bibtex: BibTeX
@article{Brinkmann2020,
   author = {Richert, E;Bartsch, S;Hillenkamp, J;Treumer, F;Tode, J;von der Burchard, C;Brinkmann, R;Klettner, A K and Roider, J},
   title = {Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums},
   journal = {Klin Monatsbl Augenheilkd},
   volume = {237(02)},
   
   pages = {192-201},
   ISSN = {0023-2165},
   DOI = {10.1055/a-0838-5633},
   year = {2020},
   type = {Journal Article}
}
Tobias Fischer, Antje Klinger, Dorthe Smolinski, Regina Orzekowsky-Schröder, Falk Nitzsche, Alfred Vogel, Gereon Hüttmann, and Andreas Gebert,
High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , pp. 1-8, 2020.
Datei: s00441-020-03167-z
Bibtex: BibTeX
@article{Fischer2020,
   author = {Fischer, T;Klinger, A;von Smolinski, D;Orzekowsky-Schroeder, R;Nitzsche, F;Bölke, T;Vogel, A;Hüttmann, G and Gebert, A},
   title = {High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures},
   journal = {Cell and Tissue Research},
   pages = {1-8},
   ISSN = {1432-0878},
   url = {https://doi.org/10.1007/s00441-020-03167-z},
   year = {2020},
   type = {Journal Article}
}
G Pieper, and P K\"{o}nig,
Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice, American Journal of Physiology-Lung Cellular and Molecular Physiology , vol. 318, no. 3, pp. 518-524, 2020. American Physiological Society Rockville, MD.
DOI:10.1152/ajplung.00287.2019
Bibtex: BibTeX
@article{pieper2020intravital,
title = {Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice},
author = {Pieper,P; Schulz-Hildebrandt, H; Mall,Marcus A; H\"{u}ttmann, G and K\"{o}nig, P},
doi = {10.1152/ajplung.00287.2019},
year = {2020},
date = {2020-02-26},
journal = {American Journal of Physiology-Lung Cellular and Molecular Physiology},
volume = {318},
number = {3},
pages = {518-524},
publisher = {American Physiological Society Rockville, MD},
abstract = {Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical coherence tomography (mOCT) is sensitive to detect and compare in vivo effects of inhaled isotonic saline, hypertonic saline and bicarbonate on mucus mobilization and clearance in Scnn1b-transgenic mice with muco-obstructive lung disease. In vivomOCT imaging showed that inhaled isotonic saline-induced rapid mobilization of mucus that was mainly transported as chunks from the lower airways of Scnn1b-transgenic mice. Hypertonic saline mobilized a significantly greater amount of mucus that showed a more uniform distribution compared to isotonic saline. Addition of bicarbonate to isotonic saline had no effect on mucus mobilization, but also led to a more uniform mucus layer compared to treatment with isotonic saline alone. mOCT can detect differences in response to mucus mobilizing interventions in vivo, and may thus support the development of more effective therapies for patients with muco-obstructive lung diseases.},
keywords = {mOCT,OCT},
pubstate = {published},
tppubtype = {article}
}
Viktoria Kleymann, Hannaes Gernandt, Karl Worthmann, Hossam S. Abbas, Ralf Brinkmann, and Matthias A. Müller,
Modeling parameter for temperature controlled retinal laser therapies, DeGruyter-at-Automatisierungstechnik , vol. 68(11), pp. 953-966, 2020.
Datei: article-p953.xml
Bibtex: BibTeX
@article{Kleymann2020,
   author = {Kleymann, V;Gernandt, H;Worthmann, K;Hossam, S.A;Brinkmann, R and Müller, A.M},
   title = {Modeling parameter for temperature controlled retinal laser therapies },
   journal = {DeGruyter-at-Automatisierungstechnik},
   volume = {68(11)},
keywords = {retinal photocoagulation, parametric model order
reduction, identification},
   pages = {953-966},
  URL = {https://www.degruyter.com/view/journals/auto/68/11/article-p953.xml},
   year = {2020},
   type = {Journal Article}
}

2019

Marco Horn, Sonja Jäckle, Felix von Haxthausen, Tim Eixmann, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, Juljan Bouchagiar, Florian Matysiak, Mark Kaschwich, Markus Kleemann, Floris Ernst, Veronica Garcia-Vazquez, and Torben Pätz,
First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures, European Journal of Vascular and Endovascular Surgery , vol. 58, no. 6, pp. e610--e611, Dez. 2019. W.B. Saunders.
DOI:10.1016/J.EJVS.2019.09.091
Bibtex: BibTeX
@proceedings{Horn2019b,
title = {First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures},
author = {Marco Horn and Sonja J\"{a}ckle and Felix von Haxthausen and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Juljan Bouchagiar and Florian Matysiak and Mark Kaschwich and Markus Kleemann and Floris Ernst and Ver\'{o}nica Garc\'{i}a-V\'{a}zquez and Torben P\"{a}tz},
doi = {10.1016/J.EJVS.2019.09.091},
issn = {1078-5884},
year  = {2019},
date = {2019-12-13},
journal = {European Journal of Vascular and Endovascular Surgery},
volume = {58},
number = {6},
pages = {e610--e611},
publisher = {W.B. Saunders},
keywords = {Sensing, Fiber},
pubstate = {published},
tppubtype = {proceedings}
}
Paula Enzian, Astrid Link, Christian Schell, Carina Malich, and Ramtin Rahmanzadeh,
Light-induced permeabilization of liposomes, vol. 11070, 08 2019. Proc.SPIE.
Datei: 12.2526071
Bibtex: BibTeX
@Proc{Enzian2019,
   author = {Enzian, P.;Link, A.;Schell, C.;Malich, C. and Rahmanzadeh, R.},
   title = {Light-induced permeabilization of liposomes},
   publisher = {Proc.SPIE},
   volume = {11070},
   series = {17th International Photodynamic Association World Congress},
   
   url = {https://doi.org/10.1117/12.2526071},
   year = {2019},
   type = {Book}
}
Hendrik Spahr, Clara Pfäffle, Sazan Burhan, Lisa Kutzner, Felix Hilge, Gereon Hüttmann, and Dierck Hillmann,
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific report , vol. 9, 08 2019.
DOI:10.1038/s41598-019-47979-8
Bibtex: BibTeX
@article{RN5217,
   author = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck},
   title = {Phase-sensitive interferometry of decorrelated speckle patterns},
   journal = {Scientific Reports},
   volume = {9},
   number = {1},
   pages = {11748},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-019-47979-8},
   url = {https://doi.org/10.1038/s41598-019-47979-8},
   year = {2019},
   type = {Journal Article}
}
Antonio López-Marín, Geert Springeling, Robert Beurskens, Heleen van Beusekom, Antonius F. W. van der Steen, Arjun D. Koch, Brett E. Bouma, Robert Huber, Gijs van Soest, and Tianshi Wang,
Motorized capsule for shadow-free OCT imaging and synchronous beam control, Opt Lett , vol. 44, no. 15, pp. 3641-3644, 08 2019. Optica Publishing Group.
DOI:10.1364/OL.44.003641
Bibtex: BibTeX
@article{Lopez-Marin:19,
author = {Antonio L\'{o}pez-Mar\'{i}n and Geert Springeling and Robert Beurskens and Heleen van Beusekom and Antonius F. W. van der Steen and Arjun D. Koch and Brett E. Bouma and Robert Huber and Gijs van Soest and Tianshi Wang},
journal = {Opt. Lett.},
keywords = {Image reconstruction; Light beams; Magnetic fields; Optical coherence tomography; Optical imaging; Reflector design},
number = {15},
pages = {3641--3644},
publisher = {Optica Publishing Group},
title = {Motorized capsule for shadow-free OCT imaging and synchronous beam control},
volume = {44},
month = {Aug},
year = {2019},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-44-15-3641},
doi = {10.1364/OL.44.003641},
abstract = {We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments using the capsule. The results show that the capsule can potentially be a useful tool for diagnostic OCT imaging and OCT-guided biopsy and therapy of the esophagus.},
}
Jan Philip Kolb, Wolfgang Draxinger, Julian Klee, Tom Pfeiffer, Matthias Eibl, Thomas Klein, Wolfgang Wieser, and Robert Huber,
Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates, PLOS ONE , vol. 14, no. 7, pp. e0213144, 03 2019.
DOI:10.1371/journal.pone.0213144
Bibtex: BibTeX
@article{Kolb2019,
   author = {Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R},
   title = {Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates},
   journal = {J pone},
 keywords = {AG-Huber_OCT},
   url = {https://doi.org/10.1371/journal.pone.0213144},
   pages = {e0213144},
   ISSN = {1932-6203},
   
   year = {2019},
   type = {Journal Article}
}
Hendrik Spahr, Clara Pfäffle, Gereon Hüttmann, and Dierck Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt. Lett. , vol. 44, no. 6, pp. 1315--1318, 03 2019. Optica Publishing Group.
DOI:10.1364/OL.44.001315
Datei: abstract.cfm
Bibtex: BibTeX
@article{RN5085,
   author = {Spahr, H;Pfäffle, C;Hüttmann, G and Hillmann, D},
   title = {Artifacts in speckle tracking and multi-aperture
Doppler OCT imaging of lateral motion},
   journal = {Optics letters},
   volume = {44(5)},
   pages = {1315-1318},
   DOI = {https://doi.org/10.1364/OL.44001315},
   url = {https://doi.org/10.1364/OL.44001315},
   year = {2019},
   type = {Journal Article}
}
R Tode, and J Roider,
Thermische Stimulation der Retina: von der translationalen Forschung zur experimentellen technischen Umsetzung, Spitzenforschung in der Ophthalmologie , vol. 117.DOG Kongress, pp. 172-175, 2019.
Datei:
Bibtex: BibTeX
@article{Tode2019,
   author = {Tode, J;von der Burchard, C;Richert, E;Klettner, A;Brinkman, R and Roider, J},
   title = {Thermische Stimulation der Retina: von der translationalen Forschung zur experimentellen technischen Umsetzung},
   journal = {Spitzenforschung in der Ophthalmologie},
   volume = {117.DOG Kongress},
   pages = {172-175},
   ISSN = {1861-4620},
   url = {https://www.dog.org/?cat=276},
   year = {2019},
   type = {Journal Article}
}
Robert Wang, and Gijs van Soest,
Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography, IEEE Transactions on Medical Imaging , vol. 39, no. 5, pp. 1535-1544, 2019.
Bibtex: BibTeX
@article{Wang2019-2,
   author = {Wang, Tianshi;Pfeiffer, Tom;Daemen, Joost;Mastik, Frits;Wieser, Wolfgang;van der Steen, AFW;Huber, Robert and van Soest, Gijs},
   title = {Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography},
   journal = {IEEE Transactions on Medical Imaging},
   volume = {39},
   number = {5},
   pages = {1535-1544},
   ISSN = {0278-0062},
   year = {2019},
   type = {Journal Article}
}
Clara Pfäffle, Hendrik Spahr, Lisa Kutzner, Sazan Burhan, Felix Hilge, Yoko Miura, Gereon Hüttmann, and Dierck Hillmann,
Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina, Optics Letters 44(23) , pp. 5671-5674, 2019.
DOI:10.1364/OL.44.005671
Bibtex: BibTeX
@article{Pfäffle2019,
   author = {Pfäffle, C;Spahr, H;Kutzner, L;Burhan, S;Hilge, F;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina},
   journal = {Optics Letters 44(23)},
 
   pages = {5671-5674},
   DOI = {10.1364/OL.44.005671},
   
   year = {2019},
   type = {Journal Article}
}
Timo Kepp, Christine Droigk, Malte Casper, Michael Evers, Gereon Hüttmann, Nunciada Salma, Dieter Manstein, Matthias P. Heinrich, and Heinz Handels,
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks, Biomed Opt Expr 10(7) , pp. 3484-3496, 2019.
DOI:10.1364/BOE.10.003484
Datei: BOE.10.003484
Bibtex: BibTeX
@article{Hüttmann2019,
   author = {Kepp, T;Droigk, C;Casper, M;Evers, M;Hüttmann, G;Salma, N;Manstein, D;Heinrich, M P. and Handels, H},
   title = {Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks},
   journal = {Biomed Opt Expr 10(7)},
  
   pages = {3484-3496},
   DOI = {10.1364/BOE.10.003484},
   url = {https://doi.org/10.1364/BOE.10.003484},
   year = {2019},
   type = {Journal Article}
}
Yoko Miura, Eric Seifert, Josua Rehra, Katharina Kern, Dirk Theisen-Kunde, Michael Denton, and Ralf Brinkmann,
Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study, Int J Hyperth , pp. 1-7, 2019.
Datei: 02656736.2019.1590653
Bibtex: BibTeX
@article{Miura2019/4,
   author = {Miura, Y;Seifert, E;Rehra, J;Kern, K;Theisen-Kunde, D;Denton, M and Brinkmann, R},
   title = {Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study},
   journal = {Int J Hyperth},
   pages = {1-7},
   ISSN = {0265-6736},
  
   url = {https://doi.org/10.1080/02656736.2019.1590653},
   year = {2019},
   type = {Journal Article}
}
B Jalali,
Time-stretch LiDAR as a spectrally scanned time-of-flight ranging camera, Nature Photonics , 2019.
Datei: 337692338_Time-stretch_LiDAR_as_a_spectrally_scanned_time-of-flight_ranging_camera
Bibtex: BibTeX
@article{Karpf2019,
   author = {Jiang, Y;Karpf, S and Jalali, B},
   title = {Time-stretch LiDAR as a spectrally scanned time-of-flight ranging camera},
   journal = {Nature Photonics},
   keywords={},
   ISSN = {1749-4893},
   URL = {https://www.researchgate.net/publication/337692338_Time-stretch_LiDAR_as_a_spectrally_scanned_time-of-flight_ranging_camera},
   year = {2019},
   type = {Journal Article}
}
 

Gereon Spahr, and Dierck Hillmann,
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific Reports , vol. 9(1), pp. 11748, 2019.
Datei: s41598-019-47979-8
Bibtex: BibTeX
@article{Spahr-2019,
   title        = {Phase-sensitive interferometry of decorrelated speckle patterns},
   author       = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck},
   year         = 2019,
   journal      = {Scientific Reports},
   volume       = {9(1)},
   pages        = 11748,
   issn         = {2045-2322},
   url          = {https://doi.org/10.1038/s41598-019-47979-8},
   type         = {Journal Article}
}
D Casper,
Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography, J Biomed Opt , pp. 046005 - 1 - 11, 2019.
Datei: 1.JBO.24.4.046005
Bibtex: BibTeX
@article{
citation_key = { Casper19},
author = { Casper, M;  Schulz-Hildebrandt, H; Evers, M; Birngruber,R; Manstein, D and Hüttmann, G},
title = {Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography},

journal = {J Biomed Opt},

pages = {046005 - 1 - 11},
year = {2019},

URL = {https://doi.org/10.1117/1.JBO.24.4.046005},
eprint = {}
}
Z Liang, and A Vogel,
Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water, Opt Expr , pp. 4672-4693, 2019.
DOI:10.1364/OE.27.004672
Bibtex: BibTeX
@article{Liang2019,
   author = {Liang, X-X; Zhang, Z and Vogel, A},
   title = {Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water},
   journal = {Opt Expr},
   
   
   pages = {4672-4693},
   DOI = {10.1364/OE.27.004672},
   
   year = {2019},
   type = {Journal Article}
}
E Bliedtner,
Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty, TVST 8(6) , 2019.
DOI:10.1167/tvst.8.6.24
Bibtex: BibTeX
@article{Bliedtner2019,
   author = {Bliedtner, K;Seifert, E and Brinkmann, R},
   title = {Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty},
   journal = {TVST 8(6)},
  
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.8.6.24},
   year = {2019},
   type = {Journal Article}
}
Ramtin Rahmanzadeh, Florian Rudnitzki, and Gereon Hüttmann,
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
DOI:10.1002/jbio.201800460
Datei: jbio.201800460
Bibtex: BibTeX
@article{Rahmanzadeh-2019,
   author = {Rahmanzadeh, R;Rudnitzki, F and Hüttmann, G},
   title = {Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes},
   journal = {Journal of Biophotonics},
   Year = {2019},
   pages = {e201800460},
   ISSN = {1864-063X},
   DOI = {10.1002/jbio.201800460},
   url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201800460},
   type = {Journal Article}
}
Robert Schmidt, and Christian Jirauschek,
Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers, pp. 1-1, 2019.
DOI:10.1109/CLEOE-EQEC.2019.8873213
Bibtex: BibTeX
@article{Schmidt2019,
   author = {Schmidt, Mark;Pfeiffer, Tom;Grill, Christin;Huber, Robert and Jirauschek, Christian},
   title = {Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers},
   pages = {1-1},
   DOI = {10.1109/CLEOE-EQEC.2019.8873213},
   year = {2019},
   type = {Book},
booktitle = { 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference}
}

Kenneth S. Barcikowski, and Alfred Vogel,
Materials synthesis in a bubble, MRS Bulletin , vol. 44 (5), pp. 382--391, 2019.
DOI:10.1557/mrs.2019.107
Bibtex: BibTeX
@article{Vogel2019-2,
    title        = {Materials synthesis in a bubble},
    author       = {Barcikowski, Stephan;Plech, Anton;Suslick, Kenneth S. and Vogel, Alfred},
    year         = 2019,
    journal      = {MRS Bulletin},
    volume       = {44 (5)},
    pages        = {382--391},
    doi          = {10.1557/mrs.2019.107},
    issn         = {0883-7694},
    type         = {Journal Article}
}
P-C South, and S A Boppart,
Local wavefront mapping in tissue using computational adaptive optics OCT, Opt Lett 44(5) , no. 5, pp. 1186--1189, 2019. OSA.
DOI:10.1364/OL.44.001186
Bibtex: BibTeX
@article{South:19,
author = { South,F A; Liu, Y-Z; Huang, P-C and Kohlfärber, T and Boppart, S A},
journal = { Opt Lett 44(5)},
pages = {1186--1189},
keywords = {Adaptive optics; Image metrics; Image quality; Refractive index; Speckle noise; Wavefront aberrations},
number = {5},
 
publisher = {OSA},
title = {Local wavefront mapping in tissue using computational adaptive optics OCT},


year = {2019},
doi = {10.1364/OL.44.001186},
abstract = {The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.},
}
T Espinoza, and s Zwart,
Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy, Particle and Particle Systems Characterization , 2019.
Datei: 335364547_Characterization_of_Micro-_and_Nanoscale_LuPO4Pr3Nd3_with_Strong_UV-C_Emission_to_Reduce_X-Ray_Doses_in_Radiation_Therapy
Bibtex: BibTeX
@article{Rahmanzadeh-2019-2,
   author = {Espinoza, S;Müller, M;Jenneboer, H;Peulen, L;Bradley, T;Purschke, M;Haase, M;Rahmanzadeh, R;Jüstel, T and Zwart, s},
   title = {Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy},
   journal = {Particle and Particle Systems Characterization},
   URL = {https://www.researchgate.net/publication/335364547_Characterization_of_Micro-_and_Nanoscale_LuPO4Pr3Nd3_with_Strong_UV-C_Emission_to_Reduce_X-Ray_Doses_in_Radiation_Therapy},
   year = {2019},
   type = {Journal Article}
}
Frank Strittmatter, Maximilian Eisel, Ralf Brinkmann, Birgit Lange, Jens Cordes, and Ronald Sroka,
Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned, Translational Biophotonics , vol. n/a, no. n/a, pp. e201900029, 2019.
DOI:10.1002/tbio.201900029
Datei: tbio.201900029
Bibtex: BibTeX
@article{Brinkmann2020,
   author = {Strittmatter, F;Eisel, M; Brinkmann, R; Cordes, J;Lange, B and Sroka, R},
   title = {Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned},
   journal = {Translational Biophotonics},
   volume = {n/a},
   number = {n/a},
   pages = {e201900029},
   ISSN = {2627-1850},
   DOI = {10.1002/tbio.201900029},
   url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/tbio.201900029},
   year = {2019},
   type = {Journal Article}
}
Dierck Hillmann, Clara Pfäffle, Hendrik Spahr, Sazan Burhan, Lisa Kutzner, Felix Hilge, and Gereon Hüttmann,
Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations, Opt Lett 44 (15) , pp. 3905-3908, 2019.
DOI:10.1364/OL.44.003905
Datei: 31368998
Bibtex: BibTeX
@article{Hillmann2019,
   author = {Hillmann, D.;Pfaffle, C.;Spahr, H.;Burhan, S.;Kutzner, L.;Hilge, F. and Hüttmann, G.},
   title = {Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations},
   journal = {Opt Lett 44 (15)},
 
   pages = {3905-3908},
   ISSN = {1539-4794 (Electronic)
0146-9592 (Linking)},
   DOI = {10.1364/OL.44.003905},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/31368998},
   year = {2019},
   type = {Journal Article}
}
D. Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Optics letters , vol. 44(5), pp. 1315-1318, 2019.
DOI:https://doi.org/10.1364/OL.44001315
Datei: OL.44001315
Bibtex: BibTeX
@article{Spahr2019,
   author = {Spahr, H;Pfäffle, C;Huettmann, G and Hillmann, D},
   title = {Artifacts in speckle tracking and multi-aperture
Doppler OCT imaging of lateral motion},
   journal = {Optics letters},
   volume = {44(5)},
   pages = {1315-1318},
   DOI = {https://doi.org/10.1364/OL.44001315},
   url = {https://doi.org/10.1364/OL.44001315},
   year = {(2019)},
   type = {Journal Article}
}
Tabea Kohlfaerber, Ding Shujun, Ramtin Rahmanzadeh, Thomas Jüngst, Jürgen Groll, Hinnerk Schulz-Hildebrandt, and Gereon Hüttmann,
Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT, Transactions on Additive Manufacturing Meets Medicine 1(1) , 2019.
DOI:10.18416/AMMM.2019.1909S03P19
Bibtex: BibTeX
@article{Kohlfärber2019,
   author = {Kohlfaerber, T;Ding, S;Rahmanzadeh, R;Jüngst, T;Groll, J;Schulz-Hildebrandt, H and Hüttmann, G},
   title = {Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT},
   journal = {Transactions on Additive Manufacturing Meets Medicine 1(1)},
   
   DOI = {10.18416/AMMM.2019.1909S03P19},
   year = {2019},
   type = {Journal Article}
}
C. Pfäffle, and D. Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt Lett , pp. 1315-1318, 2019.
Datei: OL.44.001315
Bibtex: BibTeX
@article{Spahr2019,
   author = {Spahr, H; Pfäffle, C; Huettmann, G and Hillmann, D},
   title = { Artifacts in speckle tracking and multi-aperture
Doppler OCT imaging of lateral motion},
   journal = { Opt Lett},
   pages = {1315-1318},
URL = {https://doi.org/10.1364/OL.44.001315},
   year = {2019},
   type = {Journal Article}
}
M. J. Casper, J. Glahn, M. Evers, G. Kositratna, G. H\"{u}ttmann, and D. Manstein,
Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography, Lasers in Surgery and Medicine , 2019.
DOI:10.1002/lsm.23188
Bibtex: BibTeX
@article{Casper2019b,
title = {Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography},
author = {Casper, M. J. and Glahn, J. and Evers, M. and Schulz-Hildebrandt, H. and Kositratna, G. and Birngruber, R. and H\"{u}ttmann, G. and Manstein, D.},
doi = {10.1002/lsm.23188},
year = {2019},
date = {2019-11-22},
journal = {Lasers in Surgery and Medicine},
abstract = {Background/Objectives Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining a more accurate anatomic representation of the surface capillary network in human skin using OCTA, along with proposing a new parameter, the Relative Capillary Capacity (RCC), a quantifiable proxy for assessing capillary dilation potential and permeability. Methods OCTA images were captured at baseline and after compression of the skin. Baseline images display ambient capillary perfusion, while images taken upon capillary refill display the network of existing capillaries at full capacity. An optimization-based automated vessel segmentation method was used to automatically analyze and compare OCTA image sequences obtained from two volunteers. RCC was then compared with visual impressions of capillary viability. Results Our OCTA imaging sequence provides a method for mapping cutaneous capillary networks independent of ambient perfusion. Differences between baseline and refill images clearly demonstrate the shortcomings of standard OCTA imaging and produce the RCC biometric as a quantifiable proxy for assessing capillary dilation potential and permeability. Conclusion Future dermatological OCTA diagnostic studies should implement the Capillary Refill Methods over standard imaging techniques and further explore the relevance of RCC to differential diagnosis and dermatopathology. 
\textbf{Lasers Surg. Med. © The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.}},
keywords = {mOCT},
pubstate = {published},
tppubtype = {article}
}
Yoko Miura, Britta Lewke, Alessa Hutfilz, and Ralf Brinkmann,
Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress, Nippon Ganka Gakkai Zasshi , pp. 105-114, 2019.
Datei: Disp
Bibtex: BibTeX
@article{Miura2019/3,
   
   author = {Miura, Y;Lewke, B;Hutfilz, A and Brinkmann, R},
   title = {Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress},
   journal = {Nippon Ganka Gakkai Zasshi },
  
   pages = {105-114},
   url = {http://journal.nichigan.or.jp/Disp?style=abst&vol=123&year=2019&mag=0&number=2&start=105},
   year = {2019},
   type = {Journal Article}
}

Martin Rudolf, Christine A Curcio, Ursula Schlötzer-Schrehardt, Armin Mir Mohi Sefat, Aysegül Tura, Max Philipp Brinkmann, Salvatore Grisanti, Yoko Miura, and Mahdy Ranjbar,
Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates, Invest Ophthalmol Vis Sci , pp. 461-472, 2019.
DOI:10.1167/iovs.18-25786
Datei: 30707219
Bibtex: BibTeX
@article{Miura2019-2,
   author = {Rudolf, M; Curcio, C A; Schlözer-Schrehardt, U; Sefat, A M M; Tura, A; Aherrahrou, Z; Brinkmann, M; Grisanti, S;  Miura, Y and Ranjbar, M},
   title = {Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates},
   journal = {Invest Ophthalmol Vis Sci},
   pages = {461-472},  
   url = {https://www.ncbi.nlm.nih.gov/pubmed/30707219},
   year = {2019},
   type = {Journal Article}
}
C Wang, and Z Zhang,
Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in Melanoma, ACS Applied Materials & Interfaces , 2019.
DOI:10.1021/acsami.9b09560
Bibtex: BibTeX
@article{Rahmanzadeh2019,
   author = {Wang, S;Liu, H;Xin, J;Rahmanzadeh, R;Wang, J;Yao, C and Zhang, Z},
   title = {Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in Melanoma},
   journal = {ACS Applied Materials & Interfaces},
   ISSN = {1944-8244},
   DOI = {10.1021/acsami.9b09560},  
   year = {2019},
   type = {Journal Article}
}
M. Ourak, J. Smits, L. Esteveny, G. Borghesan, A. Gijbels, L. Schoevaerdts, Y.G.M. Douven, J. Scholtes, E. Lankenau, G. H{"u}ttmann, M. Kozlovszky, Gernot Kronreif, K. Willekens, P. Stalmans, Koorosh Faridpooya, M. Cereda, A. Giani, G. Staurenghi, D. Reynaerts, and E. B. Vander Poorten,
Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation, International Journal of Computer Assisted Radiology and Surgery , vol. 14, no. 2, pp. 301--309, 2019.
DOI:10.1007/s11548-018-1829-0
Datei: s11548-018-1829-0
Bibtex: BibTeX
@Article{Ourak2019,
author="Ourak, M.
and Smits, J.
and Esteveny, L.
and Borghesan, G.
and Gijbels, A.
and Schoevaerdts, L.
and Douven, Y.
and Scholtes, J.
and Lankenau, E.
and Eixmann, T.
and Schulz-Hildebrandt, H.
and H{\"u}ttmann, G.
and Kozlovszky, M.
and Kronreif, G.
and Willekens, K.
and Stalmans, P.
and Faridpooya, K.
and Cereda, M.
and Giani, A.
and Staurenghi, G.
and Reynaerts, D.
and Vander Poorten, E. B.",
title="Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation",
journal="International Journal of Computer Assisted Radiology and Surgery",
year="2019",
month="Feb",
day="01",
volume="14",
number="2",
pages="301--309",
abstract="Retinal vein cannulation is an experimental procedure during which a clot-dissolving drug is injected into an obstructed retinal vein. However, due to the fragility and minute size of retinal veins, such procedure is considered too risky to perform manually. With the aid of surgical robots, key limiting factors such as: unwanted eye rotations, hand tremor and instrument immobilization can be tackled. However, local instrument anatomy distance and force estimation remain unresolved issues. A reliable, real-time local interaction estimation between instrument tip and the retina could be a solution. This paper reports on the development of a combined force and distance sensing cannulation needle, and its experimental validation during in vivo animal trials.",
issn="1861-6429",
doi="10.1007/s11548-018-1829-0",
url="https://doi.org/10.1007/s11548-018-1829-0",
citation_key = {Ourak2019}
}
Kumiko Hirayama, Manabu Yamamoto, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, and Shigero Honda,
Change in the Thickness of Retinal Layers after Selective Retina Therapy (SRT) in Patients with Central Serous Chorioretinopathy, Osaka City Med. , vol. 65, pp. 55-63, 2019.
Datei: G0000438repository_00306096-65-1-55
Bibtex: BibTeX
@article{Miura2019,
   author = {Hirayama, K;Manabu Yamamoto, M; Takeya Kohno, T; Miura, Y; Brinkmann, R;  Shiraki,K;Theisen-Kunde, D; and Honda, S;},
   title = {Change in the Thickness of Retinal Layers after Selective Retina
Therapy (SRT) in Patients with Central Serous Chorioretinopathy},
   journal = {Osaka City Med.},
   volume = {65},
   pages = {55-63},
   url = {http://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-65-1-55},
   year = {2019},
   type = {Journal Article}
}
R Freidank, and N. Linz,
Correction of hyperopia by intrastromal cutting and liquid filler injection, J Biomed Opt , no. 5%J Journal of Biomedical Optics, pp. 1-7, 7, 2019.
Datei: 1.JBO.24.5.058001
Bibtex: BibTeX
@article{Freidank2019,
   author = {Freidank, S;Vogel, A;Anderson, R. R.;Birngruber, R and Linz, N},
   title = {Correction of hyperopia by intrastromal cutting and liquid filler injection},
   journal = {J Biomed Opt},
  
   number = {5%J Journal of Biomedical Optics},
   pages = {1-7, 7},
   
   url = {https://doi.org/10.1117/1.JBO.24.5.058001},
   year = {2019},
   type = {Journal Article}
}
Sebastian Karpf, and B Jalali,
Fourier-domain mode-locked laser combined with a master-oscillator power amplifier architecture, J Opt Lett , pp. 1952-1955, 2019.
Datei: OL.44.001952
Bibtex: BibTeX
@article{Karpf2019,
   author = {Karpf, S and Jalali, B },
   title = {Fourier-domain mode-locked laser combined with a master-oscillator power amplifier architecture},
   journal = {J Opt Lett},
   URL = {https://doi.org/10.1364/OL.44.001952},
   pages = {1952-1955},
   ISSN = {1539-4794},
   year = {2019},
 keywords = {},
   type = {Journal Article}
}
G Burchard, and J Roider,
High-Tech-Ophthalmologie zu Hause: Das Home-Care-OCT für AMD Patienten, Spitzenforschung in der Ophthalmologie- , pp. 30-32, 2019.
Datei:
Bibtex: BibTeX
@article{von-der-Burchardt2019,
   author = {von der Burchard, C;Sudkamp, H;Tode, J;Ehlken, C;Moltmann, M;Münst, M;Theisen-Kunde, D;Koch, P;Hüttman, G and Roider, J},
   title = {High-Tech-Ophthalmologie zu Hause: Das Home-Care-OCT für AMD Patienten},
   journal = {Spitzenforschung in der Ophthalmologie- },
   pages = {30-32},
   ISSN = {1861-4620},
   url = {https://www.dog.org/?cat=276},
   year = {2019},
   type = {Journal Article}
}
J. Lange,
Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence, Lasers in Surgery and Medicine , 2019.
DOI:10.1002/lsm.23154
Datei: lsm.23154
Bibtex: BibTeX
@article{Lange2019,
   author = {Lange, B;Cordes, J. and Brinkmann, R},
   title = {Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence},
   journal = {Lasers in Surgery and Medicine},
   
   ISSN = {0196-8092},
   DOI = {10.1002/lsm.23154},
   
   year = {2019},
   type = {Journal Article}
}
Sebastian Karpf, and B Jalali,
Frequency-doubled FDML-MOPA laser in the visible, Opt Lett 44(24) , pp. 5913-5916, 2019.
DOI:10.1364/OL.44.005913
Bibtex: BibTeX
@article{karpf2019-2,
   author = {Karpf, S and Jalali, B},
   title = {Frequency-doubled FDML-MOPA laser in the visible},
   journal = {Opt Lett 44(24)},
   keywords = {},
   pages = {5913-5916},
   DOI = {10.1364/OL.44.005913},
   
   year = {2019},
   type = {Journal Article}
}
Tobias Fischer, Antje Klinger, Dorthe Smolinski, Regina Orzekowsky-Schroeder, Falk Nitzsche, Alfred Vogel, Gereon Hüttmann, and Andreas Gebert,
High-resolution imaging of the living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , 2019.
Bibtex: BibTeX
@article{Vogel-2019-1,
   author = {Fischer, T;Klinger, A;Smolinski, D von;Orzekowsky-Schroeder, R;Nitzsche, F;Vogel, A;Hüttmann, G and Gebert, A},
   title = {High-resolution imaging of the living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures},
   journal = {Cell and Tissue Research},
   ISSN = {0302-766X (Print) 
1432-0878 (Online)},
   year = {2019},
   type = {Journal Article}
}
Alessa Hutfilz, Svenja Sonntag, Britta Lewke, Dirk Theisen-Kunde, Salvatore Grisanti, Ralf Brinkmann, and Yoko Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy of the Retinal Pigment Epithelium During Wound Healing After Laser Irradiation, Translational Vision Science & Technology , vol. 8(5), 2019.
DOI:10.1167/tvst.8.5.12
Bibtex: BibTeX
@article{Hutfilz2019,
   author = {Hutfilz, A;Sonntag, S;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y},
   title = {Fluorescence Lifetime Imaging Ophthalmoscopy of the Retinal Pigment Epithelium During Wound Healing After Laser Irradiation},
   journal = {Translational Vision Science & Technology},
   volume = {8(5)},
 
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.8.5.12},
   year = {2019},
   type = {Journal Article}
}
Gereon Jäckle, and T Pätz,
Fiber optical shape sensing of flexible instruments for endovascular navigation, International Journal of Computer Assisted Radiology and Surgery , 2019.
Datei: s11548-019-02059-0
Bibtex: BibTeX
@article{Jäckle2019,
abstract = {Endovascular aortic repair procedures are currently conducted with 2D fluoroscopy imaging. Tracking systems based on fiber Bragg gratings are an emerging technology for the navigation of minimally invasive instruments which can reduce the X-ray exposure and the used contrast agent. Shape sensing of flexible structures is challenging and includes many calculations steps which are prone to different errors. To reduce this errors, we present an optimized shape sensing model.},
author = {J{\"{a}}ckle, S; Eixmann, T; Schulz-Hildebrandt, H; H{\"{u}}ttmann, Gereon and P{\"{a}}tz, T},

file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Computer Assisted Radiology and Surgery/J{\"{a}}ckle et al.{\_}2019{\_}Fiber optical shape sensing of flexible instruments for endovascular navigation.pdf:pdf},
issn = {1861-6429},
journal = {International Journal of Computer Assisted Radiology and Surgery},
month = {sep},
year = {2019},
title = {{Fiber optical shape sensing of flexible instruments for endovascular navigation}},
url = {https://doi.org/10.1007/s11548-019-02059-0},
keywords = {Endoskope, meos},

}
J. Lange,
Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence, Lasers in Surgery and Medicine , 2019.
Datei: lsm.23154
Bibtex: BibTeX
@article{Lange 2019,
   author = {Lange, B;Cordes, J. and Brinkmann, R},
   title = {Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence},
   journal = {Lasers in Surgery and Medicine},
   ISSN = {0196-8092},   
   url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/lsm.23154},
   year = {2019},
   type = {Journal Article}
}

2018

Josef Maertz, Jan Philip Kolb, Thomas Klein, Kathrin J. Mohler, Matthias Eibl, Wolfgang Wieser, Robert Huber, Siegfried Priglinger, and Armin Wolf,
Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm, Graefes Arch Clin Exp Ophthalmol , vol. 256, no. 2, pp. 289-298, Dez. 2018.
DOI:10.1007/s00417-017-3857-9
Bibtex: BibTeX
@article{Maertz2018,
   author = {Maertz, J; Kolb, J P; Klein, T; Mohler, K J; Eibl, M; Wieser, W; Huber, R; Priglinger, S and Wolf, A},
   title = {Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   number = {2},
   pages = {289-298},
   DOI = {10.1007/s00417-017-3857-9},
   url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032262413&doi=10.1007%2fs00417-017-3857-9&partnerID=40&md5=a46c315f12cf5e633ea0f7e644116eb3},
   year = {2018},
   Keywords= {En face imaging, Optical coherence tomography, Swept-source OCT, Megahertz OCT, 3D rendering, Optic disc, Optic disc pit, Optic disc pit maculopathy, AG-Huber_OCT},
   type = {Journal Article}
}
Eric Seifert, Jan Tode, Amelie Pielen, Dirk Theisen-Kunde, Carsten Framme, Johann Roider, Yoko Miura, Reginald Birngruber, and Ralf Brinkmann,
Selective retina therapy: toward an optically controlled automatic dosing, J Biomed Opt , pp. 1-12, Nov. 2018.
DOI:10.1117/1.JBO.23.11.115002
Bibtex: BibTeX
@article{seifert2018,
   author = {Seifert, E; Tode, J; Pielen, A; Theisen-Kunde, D; Framme, C; Roider, J; Miura, Y; Birngruber, R and Brinkmann, R},
   title = {Selective retina therapy: toward an optically controlled automatic dosing},
   journal = {J Biomed Opt},
   
   pages = {1-12},
   ISSN = {1560-2281 (Electronic)
1083-3668 (Linking)},
   DOI = {10.1117/1.JBO.23.11.115002},   
keywords = {algorithm, lasers in medicine, ophthalmology, retinal pigment epithelium, selective retina therapy, selectivity},
   year = {2018},
   type = {Journal Article}
}
Matthias Eibl, Daniel Weng, Hubertus Hakert, Jan Philip Kolb, Tom Pfeiffer, Jennifer Hundt, Robert Huber, and Sebastian Karpf,
Wavelength agile multi-photon microscopy with a fiber amplified diode laser, Biomedical Optics Express , vol. 9, no. 12, pp. 6273-6282, Nov. 2018. The Optical Society.
DOI:10.1364/BOE.9.006273
Bibtex: BibTeX
@article{Eibl2018,
  doi = {10.1364/boe.9.006273},
  url = {https://doi.org/10.1364/boe.9.006273},
  year = {2018},
  month = nov,
  publisher = {The Optical Society},
  volume = {9},
  number = {12},
  pages = {6273},
  author = {Matthias Eibl and Daniel Weng and Hubertus Hakert and Jan Philip Kolb and Tom Pfeiffer and Jennifer E. Hundt and Robert Huber and Sebastian Karpf},
  title = {Wavelength agile multi-photon microscopy with a fiber amplified diode laser},
  journal = {Biomedical Optics Express}
}
Tom Pfeiffer, Markus Petermann, Wolfgang Draxinger, Christian Jirauschek, and Robert Huber,
Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography, Biomed. Opt. Express , vol. 9, no. 9, pp. 4130-4148, 09 2018. Optica Publishing Group.
DOI:10.1364/BOE.9.004130
Bibtex: BibTeX
@article{Pfeiffer:18,
author = {Tom Pfeiffer and Markus Petermann and Wolfgang Draxinger and Christian Jirauschek and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Fiber optics imaging; Lasers, fiber; Optical coherence tomography; Laser stabilization ; Lasers, frequency modulated ; Analog to digital converters; Dark solitons; Image quality; Laser modes; Mode locking; Optical coherence tomography},
number = {9},
pages = {4130--4148},
publisher = {Optica Publishing Group},
title = {Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography},
volume = {9},
month = {Sep},
year = {2018},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-9-9-4130},
doi = {10.1364/BOE.9.004130},
abstract = {We investigate the origin of high frequency noise in Fourier domain mode locked (FDML) lasers and present an extremely well dispersion compensated setup which virtually eliminates intensity noise and dramatically improves coherence properties. We show optical coherence tomography (OCT) imaging at 3.2 MHz A-scan rate and demonstrate the positive impact of the described improvements on the image quality. Especially in highly scattering samples, at specular reflections and for strong signals at large depth, the noise in optical coherence tomography images is significantly reduced. We also describe a simple model that suggests a passive physical stabilizing mechanism that leads to an automatic compensation of remaining cavity dispersion in FDML lasers.},
}
Hinnerk Schulz-Hildebrandt, Tom Pfeiffer, Tim Eixmann, Sabrina Lohmann, Martin Ahrens, Josua Rehra, Wolfgang Draxinger, Peter König, Robert Huber, and Gereon Hüttmann,
High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography, Opt. Lett. , vol. 43, no. 18, pp. 4386-4389, 09 2018. Optica Publishing Group.
DOI:10.1364/OL.43.004386
Bibtex: BibTeX
@article{Schulz-Hildebrandt:18,
author = {Hinnerk Schulz-Hildebrandt and Tom Pfeiffer and Tim Eixmann and Sabrina Lohmann and Martin Ahrens and Joshua Rehra and Wolfgang Draxinger and Peter K\"{o}nig and Robert Huber and Gereon H\"{u}ttmann},
journal = {Opt. Lett.},
keywords = {Fiber optics imaging; Endoscopic imaging; Medical and biological imaging; Optical coherence tomography; Fourier domain mode locking; Image quality; Optical coherence tomography; Single mode fibers; Step index fibers; Three dimensional imaging},
number = {18},
pages = {4386--4389},
publisher = {Optica Publishing Group},
title = {High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography},
volume = {43},
month = {Sep},
year = {2018},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-43-18-4386},
doi = {10.1364/OL.43.004386},
abstract = {We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 $\mu$m was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in spirals for scanning the sample, the beam quality remains constant over the entire field of view with a diameter of 0.8 mm. The scanning frequency was adjusted to 1.22 kHz for use with a 3.28 MHz Fourier domain mode locked OCT system. Densely sampled volumes have been imaged at a rate of 6 volumes per second.},
}
Helge Sudkamp, Dierck Hillmann, Peter Koch, Malte vom Endt, Hendrik Spahr, Michael Münst, Clara Pfäffle, Reginald Birngruber, and Gereon Hüttmann,
Simple approach for aberration-corrected OCT imaging of the human retina, Opt Lett , vol. 43, no. 17, pp. 4224, 08 2018.
DOI:10.1364/ol.43.004224
Bibtex: BibTeX
@article{Sudkamp2018a,
   author = {Sudkamp, H; Hillmann, D; Koch, P;vom Endt, M; Spahr, H; Münst, M; Pfäffle, C; Birngruber, R and Hüttmann, G},
   title = {Simple approach for aberration-corrected OCT imaging of the human retina},
   journal = {Opt Lett},
   
   pages = {4224},
   ISSN = {0146-9592
1539-4794},
   DOI = {10.1364/ol.43.004224},
   year = {2018},
   type = {Journal Article},
   keyword = {Retome}
}
Mark Schmidt, Tom Pfeiffer, Christin Grill, Robert Huber, and Christian Jirauschek,
Self-Stabilization Mechanism in Fourier Domain Mode-Locked (FDML) Lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2018. Optica Publishing Group.
DOI:10.1364/OSAC.389972
Bibtex: BibTeX
@article{Schmidt:20,
author = {Mark Schmidt and Tom Pfeiffer and Christin Grill and Robert Huber and Christian Jirauschek},
journal = {OSA Continuum},
keywords = {Doppler effect; Laser modes; Laser sources; Nonlinear effects; Stimulated Raman scattering; Vertical cavity surface emitting lasers},
number = {6},
pages = {1589--1607},
publisher = {Optica Publishing Group},
title = {Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers},
volume = {3},
month = {Jun},
year = {2020},
url = {https://opg.optica.org/osac/abstract.cfm?URI=osac-3-6-1589},
doi = {10.1364/OSAC.389972},
abstract = {Understanding the dynamics of Fourier domain mode-locked (FDML) lasers is crucial for determining physical coherence limits, and for finding new superior methods for experimental realization. In addition, the rich interplay of linear and nonlinear effects in a laser ring system is of great theoretical interest. Here we investigate the dynamics of a highly dispersion-compensated setup, where over a bandwidth of more than 100\&\#x2009;nm, a highly coherent output with nearly shot-noise-limited intensity fluctuations was experimentally demonstrated. This output is called the sweet-spot. We show by numerical simulation that a finite amount of residual dispersion in the fiber delay cavity of FDML lasers can be compensated by the group delay dispersion in the swept bandpass filter, such that the intensity trace exhibits no dips or high-frequency distortions, which are the main source of noise in the laser. In the same way, a small detuning from the ideal sweep filter frequency can be tolerated. Furthermore, we find that the filter\&\#x2019;s group delay dispersion improves the coherence properties of the laser, and acts as a self-stabilizing element in the cavity. Our theoretical model is validated against experimental data, showing that all relevant physical effects for the sweet-spot operating regime are included.},
}
R Tode, and J Roider,
Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models, Transl Vis Sci Technol , vol. 7, no. 3, pp. 2, 2018.
DOI:10.1167/tvst.7.3.2
Datei: 29736323
Bibtex: BibTeX
@article{Tode2018,
   author = {Tode, J; Richert, E; Koinzer, S; Klettner, A; von der Burchard, C; Brinkmann, R; Lucius, R and Roider, J},
   title = {Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models},
   journal = {Transl Vis Sci Technol},
  
   pages = {2},
   ISSN = {2164-2591 (Print)
2164-2591 (Linking)}, 
   url = {https://www.ncbi.nlm.nih.gov/pubmed/29736323},
   year = {2018},
   type = {Journal Article}
}
J Rudnitzki, and G Huettmann,
siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase, Journal of BIOPHOTONICS , 2018.
DOI:10.1002/jbio.201700329
Bibtex: BibTeX
@article{Rahmanzadeh2018,
   author = {Rudnitzki, F; Feineis, S; Rahmanzadeh, R; Endl, E; Lutz, J; Groll, J and Huettmann, G},
   title = {siRNA release from gold nanoparticles by nanosecond pulsed
laser irradiation and analysis of the involved temperature
increase},
   journal = {Journal of BIOPHOTONICS},
  doi = {10.1002/jbio.201700329},
   

keywords = {cavitation|cell manipulation|controlled release|gold nanoparticle bio-conjugates|laser nanoeffects},
abstract = {Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particle and near the surface were calculated for the different radiant exposures. Upon irradiation with laser pulses of 4 nanosecond duration release started for both particle sizes at a calculated temperature increase of approximately 500 K. Maximum coumarin release was observed for 15 nm particles after irradiation with radiant exposure of 80 mJ cm−2 and with 32 mJ cm−2 for 30 nm particles. This corresponds to a temperature increase of 815 and 900 K, respectively. Our results show that the molecular release by nanosecond pulsed irradiation is based on a different mechanism compared to continuous or femtosecond irradiation. Local temperatures are considerably higher and it is expected that bubble formation plays a crucial role in release and damage to cellular structures. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim},
   year = {2018},
   type = {Journal Article}
}
D Borghesan, and E Vander Poorten,
Single Scan OCT-based Retina Detection for Robot-assisted Retinal Vein Cannulation, J Med Robot Res , pp. 184005, 2018.
DOI:10.1142/S2424905X18400056
Datei: S2424905X18400056
Bibtex: BibTeX
@article{borghesan2018single,
title = {Single Scan OCT-based Retina Detection for Robot-assisted Retinal Vein Cannulation},
author = {Borghesan,G; Ourak,M; Lankenau, E; H\"{u}ttmann,G; Schulz-Hildebrandt,H; Willekens,K; Stalmans, K; Reynaerts, D and Vander Poorten,E},
editor = {World Scientific},
url = {https://www.worldscientific.com/doi/abs/10.1142/S2424905X18400056},
doi = {10.1142/S2424905X18400056},
year = {2018},
date = {2018-02-12},
journal = {J Med Robot Res},

pages = {184005},
abstract = {Vitreoretinal surgery concerns a set of particularly demanding minimal invasive micro-surgical interventions at the retina. Micro-surgeons are targeting sub-millimeter-sized structures here. Tiny vessels or wafer-thin membranes are to be cannulated or need to be peeled off. The greatest care is to be displayed not to damage these fragile structures or to inadvertently injure the underlying retina. Damage to the latter is mostly irreparable and might cause permanent loss of vision. Despite the availability over excellent stereo microscopes, wide-angle lenses and powerful light source visualization remains a problem. Especially, the limited depth perception is still perceived as a major bottle-neck whereas efforts have been conducted to integrate sensing capability in today’s state-of-the-art instruments, so far, little effort has been paid to process the obtained sensor data and turns this into a reliable source of information upon which robot assistive guidance schemes could be endowed upon. This paper proposes a number of processing techniques tailored to Optical Coherence Tomography (OCT) measurements. The first results of the proposed algorithms show that it is feasible to extract good and reliable distance estimates from this otherwise rather noisy signal and from a fairly limited dataset. The used data are the so-called A-scans. These are OCT measurements consisting of a single-line image that could be captured by an instrument-mounted fiber through which the OCT signal passes back-and-forth. However, in this work, we perform a pilot study whereby the employed A-scans are extracted from B-scans that are captured by a microscope-mounted OCT scanner, rather than obtained from a probe. The performance of a first embodiment of the algorithm that is based on an Unscented Kalman Filter (UKF) is compared to the performance of a second embodiment that relies on a Particle Filter (PF), focusing on the issues in filter initialization and the tracking quality. Finally, results of UKF and PF executions on a validation dataset are presented. 
Read More: https://www.worldscientific.com/doi/abs/10.1142/S2424905X18400056},
keywords = {Endoskope},
pubstate = {published},
tppubtype = {article}
}
Jan Philip Kolb, Tom Pfeiffer, Matthias Eibl, Hubertus Hakert, and Robert Huber,
High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates, Biomed. Opt. Express , vol. 9, no. 1, pp. 120-130, 01 2018. Optica Publishing Group.
DOI:10.1364/BOE.9.000120
Bibtex: BibTeX
@article{Kolb:18,
author = {Jan Philip Kolb and Tom Pfeiffer and Matthias Eibl and Hubertus Hakert and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Medical optics instrumentation; Lasers, fiber; Medical and biological imaging; Ophthalmic optics and devices ; Optical coherence tomography; Adaptive optics; Image quality; In vivo imaging; Mode locking; Ophthalmic imaging; Three dimensional imaging},
number = {1},
pages = {120--130},
publisher = {Optica Publishing Group},
title = {High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates},
volume = {9},
month = {Jan},
year = {2018},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-9-1-120},
doi = {10.1364/BOE.9.000120},
abstract = {We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2\&\#x2219;\&\#x202F;417 kHz\&\#x202F; $=$ \&\#x202F;834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 \&\#x00B5;m axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 nm sweep range, as well as to existing spectral domain OCT data with 2.1 \&\#x00B5;m axial resolution from literature. We identify benefits of the higher resolution, for example the improved visualization of small blood vessels in the retina besides several others.},
}
Elisabeth Richert, Stefan Koinzer, Jan Tode, Kerstin Schlott, Ralf Brinkmann, Jost Hillenkamp, Alexa Klettner, and Johann Roider,
Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy, Investigative Ophthalmology & Visual Science , pp. 1323-1331, 2018.
DOI:10.1167/iovs.17-23163
Datei: iovs.17-23163
Bibtex: BibTeX
@article{Brinkmann2018,
   author = {Richert, E; Koinzer, S; Tode, J; Schlott, K; Brinkmann, R; Hillenkamp, J; Klettner, A and Roider, J},
   title = {Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy},
   journal = {Investigative Ophthalmology & Visual Science},
   
   pages = {1323-1331},
   ISSN = {1552-5783},
  
   url = {http://dx.doi.org/10.1167/iovs.17-23163},
   year = {2018},
   type = {Journal Article}
}
D. Spahr,
Interferometric detection of 3D motion using computational subapertures in optical coherence tomography, Opt Expr , pp. 18803--18816, 2018. OSA.
Datei: OE.26.018803
Bibtex: BibTeX
@article{Spahr:18,
author = { Spahr, H; Pfäffle, C; Koch,C; Sudkamp, H; Hüttmann, G und Hillmann, D},
journal = {Opt Expr},
keywords = {Funktion, Fullfield},

pages = {18803--18816},
publisher = {OSA},
title = {Interferometric detection of 3D motion using computational subapertures in optical coherence tomography},


year = {2018},
url = {https://doi.org/10.1364/OE.26.018803},

abstract = {Doppler optical coherence tomography (OCT) quantifies axial motion with high precision, whereas lateral motion cannot be detected by a mere evaluation of phase changes. This problem was solved by the introduction of three-beam Doppler OCT, which, however, entails a high experimental effort. Here, we present the numerical analogue to this experimental approach. Phase-stable complex-valued OCT datasets, recorded with full-field swept-source OCT, are filtered in the Fourier domain to limit imaging to different computational subapertures. These are used to calculate all three components of the motion vector with interferometric precision. As known from conventional Doppler OCT for axial motion only, the achievable accuracy exceeds the actual imaging resolution by orders of magnitude in all three dimensions. The feasibility of this method is first demonstrated by quantifying micro-rotation of a scattering sample. Subsequently, a potential application is explored by recording the 3D motion vector field of tissue during laser photocoagulation in ex-vivo porcine retina.},
}

Katharina Kern, Carla Lotta Mertineit, Ralf Brinkmann, and Yoko Miura,
Expression of heat shock protein 70 and cell death kinetics after different thermal impacts on cultured retinal pigment epithelial cells, Exp Eye Res , pp. 117-126, 2018.
DOI:10.1016/j.exer.2018.02.013
Bibtex: BibTeX
@article{Miura2018,
   author = {Kern, K; Mertineit, C L; Brinkmann, R and Miura, Y},
   title = {Expression of heat shock protein 70 and cell death kinetics after different thermal impacts on cultured retinal pigment epithelial cells},
   journal = {Exp Eye Res},
  
   pages = {117-126},
   ISSN = {1096-0007 (Electronic)
0014-4835 (Linking)},
   DOI = {10.1016/j.exer.2018.02.013},
   year = {2018},
   type = {Journal Article}
}
C L Evers, and D Manstein,
Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM, Scientific Reports , 2018.
DOI:10.1038/s41598-018-27093-x
Bibtex: BibTeX
@article{Evers2018,
   author = {Evers, M ;Salma, N; Osseiran, S; Casper, M; Birngruber, R; Evans, C L and Manstein, D},
   title = {Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM},
   journal = {Scientific Reports},
   
   DOI = {10.1038/s41598-018-27093-x},
   
   year = {2018},
   type = {Journal Article}
}
F Strauch, and H. P Urbach,
Creation of aspheric interfaces on an electrowetting liquid lens using surface oscillations, AIP Advances , 2018.
DOI:10.1063/1.5063994
Bibtex: BibTeX
@article{Strauch2018,
   author = {Strauch, M;Somers, P A. A. M.;Bociort, F and Urbach, H. P},
   title = {Creation of aspheric interfaces on an electrowetting liquid lens using surface oscillations},
   journal = {AIP Advances},
   
   ISSN = {2158-3226},
   DOI = {10.1063/1.5063994},
   year = {2018},
   type = {Journal Article}
}
Hinnerk Schulz-Hildebrandt, Mario Pieper, Martin Ahrens, Christian Idel, Barbara Wollenberg, Peter König, and Gereon Hüttmann,
Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography, Biomedical Optics Express , pp. 636-647, 2018.
DOI:10.1364/BOE.9.000636
Datei: abstract.cfm
Bibtex: BibTeX
@article{schulz2018novel,
title = {Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography},
author = {Schulz-Hildebrandt, H; Pieper, M; Stehmar,C; Ahrens, M; Idel, C; Wollenberg,B; K\"{o}nig,P and Gereon H\"{u}ttmann},
editor = {Optic Socie Amer},
url = {https://www.osapublishing.org/abstract.cfm?URI=boe-9-2-636
https://www.osapublishing.org/boe/viewmedia.cfm?uri=boe-9-2-636&seq=0},
doi = {10.1364/BOE.9.000636},
isbn = {10.1364/BOE.9.000636},
year = {2018},
date = {2018-01-16},
journal = {Biomedical Optics Express},

pages = {636-647},
abstract = {Intravital microscopy (IVM) offers the opportunity to visualize static and dynamic changes of tissue on a cellular level. It is a valuable tool in research and may considerably improve clinical diagnosis. In contrast to confocal and non-linear microscopy, optical coherence tomography (OCT) with microscopic resolution (mOCT) provides intrinsically cross-sectional imaging. Changing focus position is not needed, which simplifies especially endoscopic imaging. For in-vivo imaging, here we are presenting endo-microscopic OCT (emOCT). A graded-index-lens (GRIN) based 2.75 mm outer diameter rigid endoscope is providing 1.5 \textendash 2 μm nearly isotropic resolution over an extended field of depth. Spherical and chromatic aberrations are used to elongate the focus length. Simulation of the OCT image formation, suggests overall a better image quality in this range compared to a focused Gaussian beam. Total imaging depth at a reduced sensitivity and lateral resolution is more than 200 μm. Using a frame rate of 80 Hz cross-sectional images of concha nasalis were demonstrated in humans, which could resolve cilial motion, cellular structures of the epithelium, vessels and blood cells. Mucus transport velocity was determined successfully. The endoscope may be used for diagnosis and treatment control of different lung diseases like cystic fibrosis or primary ciliary dyskinesia, which manifest already at the nasal mucosa.},
keywords = {Endoskope, OCM},
pubstate = {published},
tppubtype = {article}
}
Tae Kwann Park, Juhye Choi, Young Shin Kim, Jina Kim, Ralf Brinkmann, Jungmook Lyu, and Jung Woo Han,
Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes, Graefe's Archive for Clinical and Experimental Ophthalmology , pp. 341-353, 2018.
Datei: s00417-017-3883-7
Bibtex: BibTeX
@article{Brinkmann2018,
   author = {Han, J W; Choi, J; Kim, Y S, Kim, J; Brinkmann, R; Lyu, J and Park, T K},
   title = {Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   
   pages = {341-353},
 
URL= {https://doi.org/10.1007/s00417-017-3883-7},
   year = {2018},
   type = {Journal Article}
}

2017

Alexander Baade, Claus von der Burchard, Meike Lawin, Stefan Koinzer, Benedikt Schmarbeck, Kerstin Schlott, Yoko Miura, Johann Roider, Reginald Birngruber, and Ralf Brinkmann,
Power-controlled temperature guided retinal laser therapy, J Biomed Opt , pp. 1-11, Nov. 2017.
DOI:10.1117/1.jbo.22.11.118001
Bibtex: BibTeX
@article{Baade2017,
   author = {Baade, A; von der Burchard, C; Lawin, M; Koinzer, S; Schmarbeck, B; Schlott, K; Miura, Y; Roider, J; Birngruber, R and Brinkmann, R},
   title = {Power-controlled temperature guided retinal laser therapy},
   journal = {J Biomed Opt},
   
   pages = {1-11},
   ISSN = {1083-3668},
   DOI = {10.1117/1.jbo.22.11.118001},
   year = {2017},
   type = {Journal Article}
}
Matthias Eibl, Sebastian Karpf, Hubertus Hakert, Torben Blömker, Jan Philip Kolb, Christian Jirauschek, and Robert Huber,
Pulse-to-pulse wavelength switching of a nanosecond fiber laser by four-wave mixing seeded stimulated Raman amplification, Opt. Lett. , vol. 42, no. 21, pp. 4406-4409, Nov. 2017. Optica Publishing Group.
DOI:10.1364/OL.42.004406
Bibtex: BibTeX
@article{Eibl:17,
author = {Matthias Eibl and Sebastian Karpf and Hubertus Hakert and Torben Bl\"{o}mker and Jan Philip Kolb and Christian Jirauschek and Robert Huber},
journal = {Opt. Lett.},
keywords = {Lasers, fiber; Lasers, Raman; Nonlinear optics, four-wave mixing; Scattering, stimulated Raman; Lasers, ytterbium ; Fiber lasers; Master oscillator power amplifiers; Nanosecond pulses; Raman scattering; Stimulated Brillouin scattering; Wavelength conversion},
number = {21},
pages = {4406--4409},
publisher = {Optica Publishing Group},
title = {Pulse-to-pulse wavelength switching of a nanosecond fiber laser by four-wave mixing seeded stimulated Raman amplification},
volume = {42},
month = {Nov},
year = {2017},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-42-21-4406},
doi = {10.1364/OL.42.004406},
abstract = {We report on a multi-color fiber laser based on four-wave mixing (FWM) and stimulated Raman scattering (SRS), delivering rapidly wavelength switchable narrowband output at 1064, 1122, and 1186\&\#x00A0;nm. High-power pulses from a nanosecond pulsed fiber master oscillator power amplifier at 1064\&\#x00A0;nm are combined with 1122\&\#x00A0;nm of seed light for Raman amplification at the first Stokes order in a standard single-mode fiber. With increasing power, we observe a narrowband spectral component at 1186\&\#x00A0;nm, without any additional seed or resonator at this wavelength. We analyze this occurrence of a narrowband second Stokes order both experimentally and theoretically and suggest it is a result of FWM seeding of the SRS amplification in the fiber. We demonstrate that the wavelength shifting can be controlled electronically within microseconds for very rapid and even pulse-to-pulse wavelength changes. This wavelength conversion method can extend the spectral coverage of single-wavelength fiber lasers for biomedical imaging.},
}
Sarah Kretschmer, Mario Pieper, Antje Klinger, Gereon Hüttmann, and Peter König,
Imaging of Wound Closure of Small Epithelial Lesions in the Mouse Trachea, Am J Pathol , vol. 187, no. 11, pp. 2451-2460, Nov. 2017.
DOI:10.1016/j.ajpath.2017.07.006
Bibtex: BibTeX
@article{Kretschmer2017,
   author = {Kretschmer, S; Pieper, M; Klinger, A; Hüttmann, G. and König, P.},
   title = {Imaging of Wound Closure of Small Epithelial Lesions in the Mouse Trachea},
   journal = {Am J Pathol},
   ISSN = {0002-9440},
   DOI = {10.1016/j.ajpath.2017.07.006},
 
   year = {2017},
pages = {2451-2460},
   type = {Journal Article}
}
Dierck Hillmann, Hendrik Spahr, Carola Hain, Laura Hinkel, Gesa Franke, and Gereon Hüttmann,
Off-axis reference beam for full-field swept-source OCT and holoscopy, Opt Expr , vol. 25, no. 22, pp. 27770-27784, Okt. 2017.
DOI:10.1364/OE.25.027770
Bibtex: BibTeX
@article{Hillmann2017,
   author = {Hillmann, D; Spahr, H; Sudkamp, H; Hain, C; Hinkel, L; Franke, G and Hüttmann, G},
   title = {Off-axis reference beam for full-field swept-source OCT and holoscopy},
   journal = {Opt Expr},
   
   pages = {27770-27784},
   DOI = {10.1364/OE.25.027770},
   year = {2017},
   type = {Journal Article}
}
S Ataka, S Ogawa, Yoko Miura, Takeya Kohno, and Kunihiko Shiraki,
A Comparison of Intraoperative Metrics between the Infiniti with and the Centurion without Intelligent Phacoemulsification Systems, Journal of Eye & Cataract Surgery , vol. 3, Aug. 2017.
DOI:10.21767/2471-8300.100034
Bibtex: BibTeX
@article{Miura2017,
   author = { Ataka,S;Ogawa,S; Miura,Y; Kohno,T and Shiraki, K},
   title = {A Comparison of Intraoperative Metrics between the Infiniti with and the Centurion without Intelligent Phacoemulsification Systems},
   journal = {Journal of Eye & Cataract Surgery},
   volume = {3},
   ISSN = {2571-8300},
Abstract = {Purpose: To compare the efficiency and safety of two
phacoemulsification systems, the Infiniti with intelligent
phacoemulsification (IP) and the Centurion without IP, in
terms of intraoperative metrics of phacoemulsification and
the occurrences of adverse events and intraoperative tip
obstruction.
Design: Comparative case series.
Methods: A consecutive series of 340 eyes (151 eyes with
the Infiniti, 189 eyes with the Centurion) was evaluated. A
2.4 mm sclerocorneal incision was used with the Infiniti, and
a 2.0 mm incision was used with the Centurion.
Phacoemulsification of the nucleus was performed using
the phaco chop technique, with the IP function of the
Infiniti turned on and the IP mode of the Centurion turned
off. From among the parameters displayed on the panels of
both devices, ultrasound (US) time, cumulative dissipated
energy (CDE), aspiration time, and estimated balanced salt
solution (BSS) aspiration volume were investigated and
compared between the devices. Results: A comparison of all
subjects found significant differences between the two
devices in mean CDE (p=0.02) and mean aspiration time
(p=0.003), but not in mean US time (p=0.43) or mean
estimated BSS aspiration volume (p=0.07). For grade 3
nuclei, all parameters of mean US time (p=0.0044), mean
CDE (p ≤ 0.001), mean aspiration time (p<0.001), and mean
estimated BSS aspiration volume (p=0.001) showed
significant differences favoring the Centurion.
Conclusions: Compared to the Infiniti with IP mode, cataract
surgery with the Centurion without IP mode is likely to be
performed with less phacoemulsification energy and higher
efficiency.},
   DOI = {10.21767/2471-8300.100034},
   year = {2017},
   type = {Journal Article}
}
Josef Maertz, Kathrin J. Mohler, Jan Philip Kolb, Thomas Klein, Aljoscha Neubauer, Anselm Kampik, Siegfried Priglinger, Wolfgang Wieser, Robert Huber, and Armin Wolf,
INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes, Retina , vol. 37, no. 5, pp. 906-914, 05 2017.
DOI:10.1097/iae.0000000000001260
Bibtex: BibTeX
@article{Maertz2017,
   author = {Maertz, J. and Mohler, K. J. and Kolb, J. P. and Klein, T. and Neubauer, A. and Kampik, A. and Priglinger, S. and Wieser, W. and Huber, R. and Wolf, A.},
   title = {INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes},
   journal = {Retina},
   volume = {37},
   number = {5},
   pages = {906-914},
   DOI = {10.1097/iae.0000000000001260},
   year = {2017},
keywords = {AG-Huber_OCT},
   type = {Journal Article}
}
Sebastian Karpf, Matthias Eibl, Wolfgang Wieser, Thomas Klein, and Robert Huber,
Shot-Noise Limited Time-Encoded Raman Spectroscopy, Journal of Spectroscopy , vol. 2017, pp. 1-6, 03 2017. Hindawi.
DOI:10.1155/2017/9253475
Bibtex: BibTeX
@article{Karpf2017,
   author = {Karpf, Sebastian and Eibl, Matthias and Wieser, Wolfgang and Klein, Thomas and Huber, Robert},
   title = {Shot-Noise Limited Time-Encoded Raman Spectroscopy},
   journal = {Journal of Spectroscopy},
   volume = {2017},
   pages = {1-6},
   url = {https://doi.org/10.1155/2017/9253475},
   year = {2017},
keywords = {AG-Huber_NL},
   type = {Journal Article}
}
Clara Pfäffle, Hendrik Spahr, Dierck Hillmann, Helge Sudkamp, Gesa Franke, Peter Koch, and Gereon Hüttmann,
Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited], Biomedical Optics Express , vol. 8, no. 3, pp. 1499-1511, 03 2017. https://doi.org/10.1364/BOE.8.001499 .
DOI:10.1364/BOE.8.001499
Weblink: https://doi.org/10.1364/BOE.8.001499
Datei: abstract.cfm
Bibtex: BibTeX
@article{Pfäffle2017,
   author = {Pfäffle, Clara and Spahr, Hendrik and Hillmann, Dierck and Sudkamp, Helge and Franke, Gesa and Koch, Peter and Hüttmann, Gereon},
   title = {Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited]},
   journal = {Biomedical Optics Express},
   volume = {8},
   number = {3},
   pages = {1499-1511},
   keywords = {Image reconstruction-restoration
Optical coherence tomography},
   url = {http://www.osapublishing.org/boe/abstract.cfm?URI=boe-8-3-1499},
   year = {2017},
   type = {Journal Article}
}
Thomas Klein, and Robert Huber,
High-speed OCT light sources and systems [Invited], Biomed. Opt. Express , vol. 8, no. 2, pp. 828-859, 02 2017. Optica Publishing Group.
DOI:10.1364/BOE.8.000828
Bibtex: BibTeX
@article{Klein:17,
author = {Thomas Klein and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Imaging systems; Optical coherence tomography; Lasers and laser optics; Lasers, tunable; Optical coherence tomography; Full field optical coherence tomography; High speed imaging; Image quality; Imaging systems; Light wavelength; X ray imaging},
number = {2},
pages = {828--859},
publisher = {Optica Publishing Group},
title = {High-speed OCT light sources and systems \[Invited\]},
volume = {8},
month = {Feb},
year = {2017},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-8-2-828},
doi = {10.1364/BOE.8.000828},
abstract = {Imaging speed is one of the most important parameters that define the performance of optical coherence tomography (OCT) systems. During the last two decades, OCT speed has increased by over three orders of magnitude. New developments in wavelength-swept lasers have repeatedly been crucial for this development. In this review, we discuss the historical evolution and current state of the art of high-speed OCT systems, with focus on wavelength swept light sources and swept source OCT systems.},
}
P Horstmann, and C Cursiefen,
Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography, Investig Ophthal & Vis Scie , pp. 5880-5886, 2017.
DOI:10.1167/iovs.17-22286
ISBN:1552-5783
Bibtex: BibTeX
@article{Horstmann2017,
title = {Label-Free In Vivo Imaging of Corneal Lymphatic Vessels Using Microscopic Optical Coherence Tomography},
author = {Horstmann, J; Schulz-Hildebrandt, H; Bock, F; Siebelmann, S; Lankenau, E; H\"{u}ttmann, G; Steven, P and  Cursiefen, C},
editor = {The Association Research for in Vision and Ophthalmology},
doi = {10.1167/iovs.17-22286},
isbn = {1552-5783},
year = {2017},
date = {2017-12-25},
journal = { Investig Ophthal & Vis Scie},

pages = {5880-5886},
abstract = {Purpose: Corneal neovascularization, in particular lymphangiogenesis, is a limiting factor in corneal transplant survival. Novel treatment approaches focus on (selective) inhibition and regression of lymphatic vessels. Imaging clinically invisible corneal lymphatic vessels is a prerequisite for these strategies. Using a murine model, this study investigates whether corneal lymphatic vessels can be imaged using microscopic optical coherence tomography (mOCT). 

Methods: Corneal neovascularization was induced by intrastromal placement of 11.0 nylon sutures in one eye of BALB/c mice. After 2 weeks, cross-sectional images and volumes of the corneas with a 0.5 mm lateral and axial field of view were acquired using a custom-built mOCT system enabling a resolution of 1 μm at a B-scan rate of 165/s. Three of the six animals received an additional intrastromal injection of India ink 24 hours before the measurement to stain the corneal lymphatic system in vivo. Immunohistochemistry using CD31 and LYVE-1 was used to validate the mOCT findings. 

Results: Using mOCT, lymphatic vessels were visible as dark vessel-like structures with the lumen lacking a hyperreflective wall and mostly lacking cells. However, individual, slowly moving particles, which most likely are immune cells, occasionally could be observed inside the lumen. In lymphatic vessels of ink-stained corneas, hyperreflection and shadowing underneath was observed. Ink-filled lymphatic vessels were colocalized in consecutive corneal flat mounts of the same specimen. 

Conclusions: Corneal lymphatic vessels can be imaged using mOCT. This novel approach opens new options for noninvasive clinical imaging of corneal lymphatic vessels for diagnostic and therapeutic indications.},
keywords = {OCM},
pubstate = {published},
tppubtype = {article}
}
G M Rudolf, C A Curcio, Martin Rudolf, Armin Mir Mohi Sefat, Yoko Miura, Aysegül Tura, Walter Raasch, Mahdy Ranjbar, Salvatore Grisanti, Zouhair Aherrahrou, Anna Wagner, Jeffrey D Messinger, G M Anantharamaiah, and Christine A Curcio,
ApoA-I Mimetic Peptide 4F Reduces Age-Related Lipid Deposition in Murine Bruch's Membrane and Causes Its Structural Remodeling, Curr Eye Res , pp. 1-12, 2017.
DOI:10.1080/02713683.2017.1370118
Bibtex: BibTeX
@article{Miura2017,
   author = {Rudolf, M; Mir Mohi Sefat, A; Miura, Y; Tura, A; Raasch, W; Ranjbar, M; Grisanti, S; Aherrahrou, Z; Wagner, A; Messinger, J D; Garber, D W; Anantharamaiah, G M and Curcio, C A},
   title = {ApoA-I Mimetic Peptide 4F Reduces Age-Related Lipid Deposition in Murine Bruch's Membrane and Causes Its Structural Remodeling},
   journal = {Curr Eye Res},
   pages = {1-12},
   ISSN = {0271-3683},
   DOI = {10.1080/02713683.2017.1370118},
   year = {2017},
   type = {Journal Article},

}
Christian Buj, Michael Münter, Benedikt Schmarbeck, Jens Horstmann, Gereon Hüttmann, and Ralf Brinkmann,
Noncontact holographic detection for photoacoustic tomography, J Biomed Opt , vol. 22, no. 10, pp. 1-14, 2017.
DOI:10.1117/1.jbo.22.10.106007
Bibtex: BibTeX
@article{Buj2017,
   author = {Buj, C; Münter, M; Schmarbeck, B; Horstmann, J; Hüttmann, G and Brinkmann, R},
   title = {Noncontact holographic detection for photoacoustic tomography},
   journal = {J Biomed Opt},
   
   pages = {1-14},
   DOI = {10.1117/1.jbo.22.10.106007},
   year = {2017},
   type = {Journal Article}
}


Ievgen Verbytskyi, Michael Münter, Christian Buj, and Ralf Brinkmann,
A Problem of a Displacement Calculation of Tissue Surface in Non-Contact Photoacoustic Tomography, Naukovi Visti NTUU KPI , no. 2, pp. 58-64, 2017.
DOI:10.20535/1810-0546.2017.2.98021
Datei: 1810-0546.2017.2.98021
Bibtex: BibTeX
@article{Verbytskyi2017,
   author = {Verbytskyi, Ievgen and Münter, Michael and Buj, Christian and Brinkmann, Ralf},
   title = {A Problem of a Displacement Calculation of Tissue Surface in Non-Contact Photoacoustic Tomography},
   journal = {Naukovi Visti NTUU KPI},
   number = {2},
   pages = {58-64},
   ISSN = {2519-8890},
   url = {http://dx.doi.org/10.20535/1810-0546.2017.2.98021},
   year = {2017},
   type = {Journal Article}
}
Birgit Lange, Dieter Jocham, Ralf Brinkmann, and Jens Cordes,
Stone/tissue differentiation for Holmium laser lithotripsy using autofluorescence: Clinical proof of concept study, Lasers in Surgery and Medicine , vol. 49, no. 4, pp. 361-365, 2017.
DOI:10.1002/lsm.22611
Bibtex: BibTeX
@article{Lange2017,
   author = {Lange, Birgit and Jocham, Dieter and Brinkmann, Ralf and Cordes, Jens},
   title = {Stone/tissue differentiation for Holmium laser lithotripsy using autofluorescence: Clinical proof of concept study},
   journal = {Lasers in Surgery and Medicine},
   volume = {49},
   number = {4},
   pages = {361-365},
   ISSN = {1096-9101},
   DOI = {10.1002/lsm.22611},
   year = {2017},
   type = {Journal Article}
}
Matthias Eibl, Sebastian Karpf, Daniel Weng, Hubertus Hakert, Tom Pfeiffer, Jan Philip Kolb, and Robert Huber,
Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate, Biomed. Opt. Express , vol. 8, no. 7, pp. 3132-3142, 2017. Optica Publishing Group.
DOI:10.1364/BOE.8.003132
Bibtex: BibTeX
@article{Eibl:17,
author = {Matthias Eibl and Sebastian Karpf and Daniel Weng and Hubertus Hakert and Tom Pfeiffer and Jan Philip Kolb and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Fiber optics imaging; Nonlinear optics, fibers; Lasers, fiber; Lifetime-based sensing; Fluorescence microscopy; Nonlinear microscopy; Fourier domain mode locking; Image quality; Imaging techniques; Laser sources; Pulsed fiber lasers; Three dimensional sensing},
number = {7},
pages = {3132--3142},
publisher = {Optica Publishing Group},
title = {Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate},
volume = {8},
month = {Jul},
year = {2017},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-8-7-3132},
doi = {10.1364/BOE.8.003132},
abstract = {Two-photon-excited fluorescence lifetime imaging microscopy (FLIM) is a chemically specific 3-D sensing modality providing valuable information about the microstructure, composition and function of a sample. However, a more widespread application of this technique is hindered by the need for a sophisticated ultra-short pulse laser source and by speed limitations of current FLIM detection systems. To overcome these limitations, we combined a robust sub-nanosecond fiber laser as the excitation source with high analog bandwidth detection. Due to the long pulse length in our configuration, more fluorescence photons are generated per pulse, which allows us to derive the lifetime with a single excitation pulse only. In this paper, we show high quality FLIM images acquired at a pixel rate of 1 MHz. This approach is a promising candidate for an easy-to-use and benchtop FLIM system to make this technique available to a wider research community.},
}
F Strauch, and H. P Urbach,
Study of surface modes on a vibrating electrowetting liquid lens, Applied physics Letters , pp. 171106, 2017.
DOI:10.1063/1.4999562
Datei: 1.4999562
Bibtex: BibTeX
@article{Strauch2017,
   author = {Strauch, M;Shao, Y;Bociort, F and Urbach, H. P},
   title = {Study of surface modes on a vibrating electrowetting liquid lens},
journal = {Applied physics Letters},

  
   pages = {171106},
   DOI = {10.1063/1.4999562},
keywords = {lenses,surface waves(fluid),vibrations,wetting},
abstract = {The increased usage of liquid lenses motivates us to investigate surface waves on the liquid's surface. During fast focal switching, the surface waves decrease the imaging quality. We propose a model that describes the surface modes appearing on a liquid lens and predicts the resonance frequencies. The effects of those surface modes on a laser beam are simulated using Fresnel propagation, and the model is verified experimentally.
We acknowledge the use of an educational licence of CODE V and LightTools. This work was funded through the Spectr@phone project (IPD 12017) of the IOP Photonic Devices program of RVO.},

   url = {https://aip.scitation.org/doi/abs/10.1063/1.4999562},
   year = {2017},
   type = {Journal Article}
}
Jan Tode, Elisabeth Richert, Claus von der Burchard, Stefan Koinzer, Alexa Klettner, Ralf Brinkmann, and Johann Roider,
Schonende retinale Lasertherapien als Behandlungsoption der trockenen AMD, Spitzenforschung in der Ophthalmologie , pp. 170-173, 2017.
Datei: DOG_Sonderband_WEB-min.pdf
Bibtex: BibTeX
@article{Brinkmann2017,
   author = {Tode, J;Richert, E;von der Burchard, C;Koinzer, S;Klettner, A;Brinkmann, R and Roider, J},
   title = {Schonende retinale Lasertherapien als Behandlungsoption der trockenen AMD },
   journal = {Spitzenforschung in der Ophthalmologie},
   pages = {170-173},
   ISSN = {1861-4620},
   url = {https://www.dog.org/wp-content/uploads/2009/12/DOG_Sonderband_WEB-min.pdf#page=1&zoom=auto,-57,877},
   year = {2017},
   type = {Journal Article}
}
Christian Jirauschek,
Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers, Journal of the Optical Society of America B , vol. 34, no. 6, pp. 1135-1146, 2017.
DOI:10.1364/JOSAB.34.001135
Datei: abstract.cfm
Bibtex: BibTeX
  @article{Jirauschek2017,
   author = {Jirauschek, Christian and Huber, Robert},
   title = {Efficient simulation of the swept-waveform polarization dynamics in fiber spools and Fourier domain mode-locked (FDML) lasers},
   journal = {Journal of the Optical Society of America B},
   volume = {34},
   number = {6},
   pages = {1135-1146},
   DOI = {10.1364/JOSAB.34.001135},
   url = {http://josab.osa.org/abstract.cfm?URI=josab-34-6-1135},
   year = {2017},
   type = {Journal Article}
}

   abstract = {We present a theoretical model and its efficient numerical implementation for the simulation of wavelength-swept waveform propagation in fiber systems such as Fourier domain mode-locked (FDML) lasers, fully accounting for the polarization dynamics in fiber spools and further polarization-dependent optical components in the setup. This approach enables us to perform long-time simulations of the FDML laser dynamics over more than 100,000 cavity round trips, as required for some FDML configurations to ensure convergence to the steady-state operating regime. The model is validated against experimental results for single propagation through a fiber spool and for stationary FDML operation. The polarization dynamics due to the fiber spool, inducing polarization-mode dispersion, bending birefringence as well as cross-phase modulation, and other optical components such as the Faraday-rotating mirror used for polarization compensation is thoroughly investigated.},
   keywords = {Laser theory
Lasers, tunable
Optical coherence tomography
Birefringence
Polarization
Pulses
AG-Huber_FDML},
   url = {https://www.osapublishing.org/josab/abstract.cfm?uri=josab-34-6-1135},
   year = {2017},
   type = {Journal Article}
}
Cuiping Yao, Florian Rudnitzki, Gereon Hüttmann, Zhenxi Zhang, and Ramtin Rahmanzadeh,
Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation, International Journal of Nanomedicine , vol. 12, pp. 5659-5672, 2017.
DOI:10.2147/IJN.S140620
Bibtex: BibTeX
@article{Yao2017,
   author = {Yao, C; Rudnitzki, F; Hüttmann, G; Zhang, Zand Rahmanzadeh, R},
   title = {Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation},
journal = {International Journal of Nanomedicine},
  
   pages = {5659-5672},
   DOI = {10.2147/IJN.S140620},
   year = {2017},
   type = {Journal Article}
}
Yoko Miura, Joachim Pruessner, Carla Lotta Mertineit, Katharina Kern, Michael Münter, Moritz Moltmann, Veit Danicke, and Ralf Brinkmann,
Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects, J Vis Exp , 2017.
DOI:10.3791/54326
Bibtex: BibTeX
@article{Miura2017,
   author = {Miura, Y; Pruessner, J; Mertineit, C L; Kern, K; Muenter, M; Moltmann, M; Danicke, V and Brinkmann, R},
   title = {Continuous-wave Thulium Laser for Heating Cultured Cells to Investigate Cellular Thermal Effects},
   journal = {J Vis Exp},
   
   ISSN = {1940-087x},
   DOI = {10.3791/54326},
   year = {2017},
   type = {Journal Article}
  } 

R Seiler, and I E Kochevar,
Interface bonding with corneal crosslinking (CXL) after LASIK ex vivo, Investig Ophthal and Vis Scie , pp. 6292-6298, 2017.
DOI:10.1167/iovs.17-22426
Bibtex: BibTeX
@article{Seiler2017,
   author = {Seiler, T G; Engler, M; Beck, E; Birngruber, R and Kochevar, I E},
   title = {Interface bonding with corneal crosslinking (CXL) after LASIK ex vivo},
   journal = {Investig Ophthal and Vis Scie},
   
   pages = {6292-6298},
   DOI = {10.1167/iovs.17-22426},
   
   year = {2017},
   type = {Journal Article}
}

2016

J. Horstmann, S. Siebelmann, I. Glasunow, A. Schadschneider, and Gereon Hüttmann,
OCT verstehen – Teil 2: Praktische Aspekte und Anwendung, Augenheilkunde up2date , vol. 6, no. 04, pp. 305-320, Nov. 2016.
DOI:10.1055/s-0042-117459
Bibtex: BibTeX
@article{Horstmann2016,
   author = {Horstmann, J. and Siebelmann, S. and Schulz-Hildebrandt, H. and Glasunow, I. and Schadschneider, A. and Hüttmann, G.},
   title = {OCT verstehen – Teil 2: Praktische Aspekte und Anwendung},
   journal = {Augenheilkunde up2date},
   volume = {6},
   number = {04},
   pages = {305-320},
   ISSN = {1616-9719},
   DOI = {10.1055/s-0042-117459},
   year = {2016},
   type = {Journal Article}
}
Helge Sudkamp, Peter Koch, Hendrik Spahr, Dierck Hillmann, Gesa Franke, Michael Münst, Fred Reinholz, Reginald Birngruber, and Gereon Hüttmann,
In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography, Optics Letters , vol. 41, no. 21, pp. 4987-4990, Nov. 2016.
DOI:10.1364/OL.41.004987
Datei: abstract.cfm
Bibtex: BibTeX
@article{RN4897,
   author = {Sudkamp, Helge and Koch, Peter and Spahr, Hendrik and Hillmann, Dierck and Franke, Gesa and Münst, Michael and Reinholz, Fred and Birngruber, Reginald and Hüttmann, Gereon},
   title = {In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography},
   journal = {Optics Letters},
   volume = {41},
   number = {21},
   pages = {4987-4990},
   DOI = {10.1364/OL.41.004987},
   url = {http://ol.osa.org/abstract.cfm?URI=ol-41-21-4987},
   year = {2016},
   type = {Journal Article}
}
Hendrik Spahr, Dierck Hillmann, Carola Hain, Clara Pfäffle, Helge Sudkamp, Gesa Franke, Peter Koch, and Gereon Hüttmann,
Darstellung von Blutfluss und Pulsation in retinalen Gefäßen mit Full-Field-Swept-Source-OCT, Klin Monatsbl Augenheilkd , vol. 233, no. 12, pp. 1324-1330, Okt. 2016.
DOI:10.1055/s-0042-120279
Bibtex: BibTeX
@article{Spahr2016,
   author = {Spahr, H. and Hillmann, D. and Hain, C. and Pfäffle, C. and Sudkamp, H. and Franke, G. and Koch, P. and Hüttmann, G.},
   title = {Darstellung von Blutfluss und Pulsation in retinalen Gefäßen mit Full-Field-Swept-Source-OCT},
   journal = {Klin Monatsbl Augenheilkd},
   volume = {233},
   number = {12},
   pages = {1324-1330},
   ISSN = {0023-2165},
   DOI = {10.1055/s-0042-120279},
   year = {2016},
   type = {Journal Article}
}
Hinnerk Schulz-Hildebrandt, Mario Pieper, J. Kasper, N. Traulsen, M. Mall, Peter König, and Gereon Hüttmann,
Towards automated evaluation of mucus transport measured by microscopic OCT (mOCT) during hypertonic saline treatment of Cystic Fibrosis, Pneumologie , vol. 70, no. 07, pp. 1-48, 07 2016.
DOI:10.1055/s-0036-1584651
Bibtex: BibTeX
@article{Schulz-Hildebrandt2016,
   author = {Schulz-Hildebrandt, H. and Pieper, M. and Kasper, J. and Traulsen, N. and Mall, M. and König, P. and Hüttmann, G.},
   title = {Towards automated evaluation of mucus transport measured by microscopic OCT (mOCT) during hypertonic saline treatment of Cystic Fibrosis},
   journal = {Pneumologie},
   volume = {70},
   number = {07},
   pages = {1-48},
   ISSN = {0934-8387},
   DOI = {10.1055/s-0036-1584651},
   year = {2016},
   type = {Journal Article}
}
Sebastian Karpf, Matthias Eibl, Benjamin Sauer, Fred Reinholz, Gereon Hüttmann, and Robert Huber,
Two-photon microscopy using fiber-based nanosecond excitation, Biomed. Opt. Express , vol. 7, no. 7, pp. 2432-2440, 07 2016. Optica Publishing Group.
DOI:10.1364/BOE.7.002432
Bibtex: BibTeX
@article{Karpf:16,
author = {Sebastian Karpf and Matthias Eibl and Benjamin Sauer and Fred Reinholz and Gereon H\"{u}ttmann and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Fiber optics imaging; Nonlinear optics, fibers; Lasers, fiber; Fluorescence microscopy; Nonlinear microscopy; Femtosecond pulses; In vivo imaging; Laser sources; Nanosecond pulses; Optical systems; Ultrafast lasers},
number = {7},
pages = {2432--2440},
publisher = {Optica Publishing Group},
title = {Two-photon microscopy using fiber-based nanosecond excitation},
volume = {7},
month = {Jul},
year = {2016},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-7-7-2432},
doi = {10.1364/BOE.7.002432},
abstract = {Two-photon excitation fluorescence (TPEF) microscopy is a powerful technique for sensitive tissue imaging at depths of up to 1000 micrometers. However, due to the shallow penetration, for in vivo imaging of internal organs in patients beam delivery by an endoscope is crucial. Until today, this is hindered by linear and non-linear pulse broadening of the femtosecond pulses in the optical fibers of the endoscopes. Here we present an endoscope-ready, fiber-based TPEF microscope, using nanosecond pulses at low repetition rates instead of femtosecond pulses. These nanosecond pulses lack most of the problems connected with femtosecond pulses but are equally suited for TPEF imaging. We derive and demonstrate that at given cw-power the TPEF signal only depends on the duty cycle of the laser source. Due to the higher pulse energy at the same peak power we can also demonstrate single shot two-photon fluorescence lifetime measurements.},
}
Robert Huber, Lars Dworak, Jacques E. Moser, Michael Grätzel, and Josef Wachtveitl,
Beyond Vibrationally Mediated Electron Transfer: Coherent Phenomena Induced by Ultrafast Charge Separation, The Journal of Physical Chemistry C , vol. 120, no. 16, pp. 8534-8539, 04 2016.
DOI:10.1021/acs.jpcc.6b02012
Bibtex: BibTeX
@article{doi:10.1021/acs.jpcc.6b02012,
author = {Huber, Robert and Dworak, Lars and Moser, Jacques E. and Grätzel, Michael and Wachtveitl, Josef},
title = {Beyond Vibrationally Mediated Electron Transfer: Coherent Phenomena Induced by Ultrafast Charge Separation},
journal = {The Journal of Physical Chemistry C},
volume = {120},
number = {16},
pages = {8534-8539},
year = {2016},
doi = {10.1021/acs.jpcc.6b02012},

URL = { 
        https://doi.org/10.1021/acs.jpcc.6b02012
    
},
eprint = { 
        https://doi.org/10.1021/acs.jpcc.6b02012
    
}
,
    abstract = { Wave packet propagation succeeding electron transfer (ET) from alizarin dye molecules into the nanocrystalline TiO2 semiconductor has been studied by ultrafast transient absorption spectroscopy. Because of the ultrafast time scale of the ET reaction of about 6 fs, the system shows substantial differences to molecular ET systems. We show that the ET process is not mediated by molecular vibrations, and therefore classical ET theories lose their applicability. Here the ET reaction itself prepares a vibrational wave packet and not the electromagnetic excitation by the laser pulse. Furthermore, the generation of phonons during polaron formation in the TiO2 lattice is observed in real time for this system. The presented investigations enable an unambiguous assignment of the involved photoinduced mechanisms and can contribute to a corresponding extension of molecular ET theories to ultrafast ET systems like alizarin/TiO2. }
}
Gereon Hüttmann, Moritz Moltmann, Hendrik Spahr, Jan Tode, Anna Roeck, Dirk Theisen-Kunde, Stefan Koinzer, and Ralf Brinkmann,
Retinal lesion formation during photocoagulation investigated by high-speed 1060 nm Doppler-OCT: first clinical results, Investigative Ophthalmology & Visual Science , vol. 57, no. 12, pp. 5852-5852, 2016. https://iovs.arvojournals.org/article.aspx?articleid=2563849 .
Weblink: https://iovs.arvojournals.org/article.aspx?articleid=2563849
Datei:
Bibtex: BibTeX
@article{Hüttmann2016,
   author = {Huttmann, Gereon and Moltmann, Moritz and Spahr, Hendrik and Tode, Jan and de Roeck, Anna and Theisen-Kunde, Dirk and Birngruber, Reginald and Koinzer, Stefan and Brinkmann, Ralf},
   title = {Retinal lesion formation during photocoagulation investigated by high-speed 1060 nm Doppler-OCT: first clinical results},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {57},
   number = {12},
   pages = {5852-5852},
   abstract = {Abstract Purpose : The molecular processes during heating with a photocoagulation laser, particularly in sub-visible or mere thermal stimulation treatment, have only partly been understood, and different theories exist that try to explain its clinical efficacy. Optical coherence tomography (OCT) was successfully used to grade lesions with high accuracy 1 hour after the treatments and beyond. During the irradiation, changes in tissue scattering and, by use of the Doppler signal, tissue motion caused by thermal expansion and coagulation-induced tissue contraction were shown to correlate ex-vivo and in rabbits with the strength of photocoagulation lesions. Aim of this study was to validate feasibility and reproducibility of these results in humans. Methods : In an ongoing study more than 100 lesions of three patients have been imaged with a slitlamp-based OCT (1060 nm, 90,000 A-scans/s) with varying irradiance during laser exposure. Durations of the exposure were 50 ms and 200 ms; spot size was 300 µm. Eye movements and heart beat were corrected by cross-correlation of the images. Increased tissue scattering and movement of the neuronal retina due to thermal expansion were determined from the image sequences with 3 ms temporal resolution. Results : In the first treatments with this prototype device, we received acceptable image quality in 1/3 of the lesions. Changes in the neuronal retina were successful visualized during and after the laser irradiation, demonstrating the feasibility of a real-time assessment of initial effects of photocoagulation in humans. Lesion visibility in standard, reflection-based OCT was much weaker during treatment compared to 1 hour afterwards. Increased tissue scattering was observed in stronger lesions already during the laser irradiation. At reduced irradiance, scattering increase was only observed after the end of irradiation. However, tissue motion towards the vitreous was still observed in these cases. Conclusions : In conclusion, high-speed OCT recording during photocoagulation measures initial tissue changes during photocoagulation in humans. It may enhance our understanding of the tissue dynamics right after laser irradiation. It may provide useful information for a real-time dosage control as well. This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.},
   ISSN = {1552-5783},
   url = {http://dx.doi.org/},
   year = {2016},
   type = {Journal Article}
}
H. D. Kim, S. Y. Jang, S. H. Lee, Y. S. Kim, Y. H. Ohn, and T. K. Park,
Retinal Pigment Epithelium Responses to Selective Retina Therapy in Mouse Eyes, Invest Ophthalmol Vis Sci , vol. 57, no. 7, pp. 3486-95, 2016.
DOI:10.1167/iovs.16-19508
Bibtex: BibTeX
@article{Kim2016,
   author = {Kim, H. D. and Jang, S. Y. and Lee, S. H. and Kim, Y. S. and Ohn, Y. H. and Brinkmann, R. and Park, T. K.},
   title = {Retinal Pigment Epithelium Responses to Selective Retina Therapy in Mouse Eyes},
   journal = {Invest Ophthalmol Vis Sci},
   volume = {57},
   number = {7},
   pages = {3486-95},
   abstract = {PURPOSE: To investigate the characteristics of retinal pigment epithelium (RPE) and retinal damage induced by selective retina therapy (SRT) in mice, and to elucidate longitudinal changes in RPE cells. METHODS: C57BL/6J mice received SRT and continuous-wave laser photocoagulation (cwPC). The cell death pattern was evaluated using TUNEL assay, and proliferative potential of the RPE cells was evaluated using 5-ethynyl-2'-dexoyuridine (EdU) assay. To investigate the cell-cell integrity of RPE cells, beta-catenin staining was performed. The number and hexagonality of RPE cells in the SRT-treated area were estimated using a Voronoi diagram with time periods of 3 hours to 14 days. Antibodies to microphthalmia-associated transcription factor (MiTF) and orthodenticle homeobox 2 (Otx2) were used to confirm the specific characteristics of RPE cells in the SRT-treated area. RESULTS: The number of TUNEL-positive cells located in the neural retina was significantly lower in lesions treated with SRT compared to those treated with cwPC. EdU-positive RPE cells were first detected 3 to 12 hours after SRT, and increased until 3 to 7 days after SRT. beta-catenin staining showed that hexagonality was compromised and subsequently, RPE cells expanded in size within the targeted location. The number of RPE cells in SRT lesions decreased gradually until 12 hours after SRT and recovered by 14 days. Upregulated expression of MiTF and Otx2 was observed for 2 weeks in the SRT lesions. CONCLUSIONS: Selective retina therapy seems to induce selective RPE damage without collateral thermal injury in the neural retina. Furthermore, SRT-treated lesions recovered by proliferation of RPE cells that were present in the treated lesions and by expansion of adjacent RPE cells.},
   ISSN = {0146-0404},
   DOI = {10.1167/iovs.16-19508},
   year = {2016},
   type = {Journal Article}
}
S. Kang, Y. G. Park, J. R. Kim, E. Seifert, and Y. J. Roh,
Selective Retina Therapy in Patients With Chronic Central Serous Chorioretinopathy: A Pilot Study, Medicine (Baltimore) , vol. 95, no. 3, pp. e2524, 2016.
DOI:10.1097/md.0000000000002524
Bibtex: BibTeX
@article{Kang1016,
   author = {Kang, S. and Park, Y. G. and Kim, J. R. and Seifert, E. and Theisen-Kunde, D and Brinkman, R and Roh, Y. J.},
   title = {Selective Retina Therapy in Patients With Chronic Central Serous Chorioretinopathy: A Pilot Study},
   journal = {Medicine (Baltimore)},
   volume = {95},
   number = {3},
   pages = {e2524},
   note = {1536-5964
Kang, Seungbum
Park, Young Gun
Kim, Jae Ryun
Seifert, Eric
Dirk, Theisen-Kunde
Ralf, Brinkmann
Roh, Young Jung
Journal Article
United States
Medicine (Baltimore). 2016 Jan;95(3):e2524. doi: 10.1097/MD.0000000000002524.},
   abstract = {We evaluated visual outcomes, changes of maximum macular thickness (MMT) and subretinal fluid (SRF), and safety in patients with chronic central serous chorioretinopathy (CSC) after treatment with selective retina therapy (SRT). Retrospective cohort study of patients with chronic CSC presenting to a university-based hospital from January 2014 through January 2015 was conducted. A total of 12 eyes of 12 patients with chronic CSC lasting for at least 3 months was recruited. The follow-up period ranged from 3 to 12 months. Following evaluation of test spots at temporal arcades, SRT (Q-switched neodymium-doped yttrium lithium fluoride [Nd:YLF] laser; wavelength, 527 nm, pulse duration, 1.7 microsececond) was applied to the surrounding areas of leakage observed on fluorescein angiogram and/or pigment epithelial detachment (PED). Changes in best-correct visual acuity (BCVA), MMT, and SRF and macular sensitivity (MS) by microperimetry (MP) were evaluated. Eyes received treatment in a mean of 3.83 spots at the pulse energy of 65 to 90 muJ. Mean BCVA (logMAR) improved from 0.23 +/- 0.12 at baseline to 0.14 +/- 0.13 at 3 months. MMT decreased from 341.4 +/- 85.5 mum at baseline to 236.0 +/- 57.9 mum at 3 months. SRF completely resolved in 75% (9 eyes) at 3 months. Large PEDs (2 eyes) were flattened at 3 months. Retreatment was performed in 4 eyes. MP showed no evidence of scotoma around SRT-treated lesions. SRT treatment targeting the surrounding area of leakage point showed favorable visual and structural outcomes in chronic CSC patients without the risk of scotoma.},
   ISSN = {0025-7974},
   DOI = {10.1097/md.0000000000002524},
   year = {2016},
   type = {Journal Article}
}
Ayako Yasui, Manabu Yamamoto, Kumiko Hirayama, Kunihiko Shiraki, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, and Takeya Kohno,
Retinal sensitivity after selective retina therapy (SRT) on patients with central serous chorioretinopathy, Graefe's Archive for Clinical and Experimental Ophthalmology , pp. 1-12, 2016.
Datei: s00417-016-3441-8
Bibtex: BibTeX
@article{Yasui2016,
   author = {Yasui, Ayako and Yamamoto, Manabu and Hirayama, Kumiko and Shiraki, Kunihiko and Theisen-Kunde, Dirk and Brinkmann, Ralf and Miura, Yoko and Kohno, Takeya},
   title = {Retinal sensitivity after selective retina therapy (SRT) on patients with central serous chorioretinopathy},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   pages = {1-12},
   abstract = {To assess retinal sensitivity after selective retina therapy (SRT) in patients with central serous chorioretinopathy (CSCR).},
   ISSN = {1435-702X},
   url = {http://dx.doi.org/10.1007/s00417-016-3441-8},
   year = {2016},
   type = {Journal Article}
}
Y. G. Park, J. R. Kim, S. Kang, E. Seifert, and Y. J. Roh,
Safety and efficacy of selective retina therapy (SRT) for the treatment of diabetic macular edema in Korean patients, Graefes Arch Clin Exp Ophthalmol , 2016.
DOI:10.1007/s00417-015-3262-1
Bibtex: BibTeX
@article{Park2016,
   author = {Park, Y. G. and Kim, J. R. and Kang, S. and Seifert, E. and Theisen-Kunde, D. and Brinkmann, R. and Roh, Y. J.},
   title = {Safety and efficacy of selective retina therapy (SRT) for the treatment of diabetic macular edema in Korean patients},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   note = {1435-702x
Park, Young Gun
Kim, Jae Ryun
Kang, Seungbum
Seifert, Eric
Theisen-Kunde, Dirk
Brinkmann, Ralf
Roh, Young-Jung
Journal article
Graefes Arch Clin Exp Ophthalmol. 2016 Jan 23.},
   abstract = {PURPOSE: Selective retina therapy (SRT) stimulates retinal pigment epithelium (RPE) cell migration and proliferation into irradiated areas. The objective of this study was to evaluate the efficacy and safety of SRT in Korean patients with clinically significant diabetic macular edema (DME). METHODS: Prospective non-randomized interventional case series study. Twenty-three eyes of 21 patients with clinically significant DME were treated with SRT and followed for 6 months. Patients underwent an evaluation of best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Microperimetry was employed to measure macular sensitivity within the central 10 degrees field, and the central macular thickness (CMT) and maximum macular thickness (MMT) were measured. RESULTS: An improvement in BCVA of one to two ETDRS lines was observed in 41.2 % of patients and an improvement of greater than two lines in 29.4 %. Although there was no significant change in CMT (P > 0.05), MMT decreased from 465.8 +/- 87.4 mum to 434.3 +/- 83.9 mum (P = 0.006), and mean macular sensitivity increased from 20.8 +/- 3.4dB to 22.5 +/- 3.5dB (P = 0.02). CONCLUSIONS: The gains in BCVA and improvement in macular sensitivity demonstrated that SRT may be used as an effective and safe treatment modality in Korean patients with clinically significant DME.},
   keywords = {Diabetic macular edema
Dosimetry
Microperimetry
Retinal pigment epithelium
Selective retina therapy},
   ISSN = {0721-832x},
   DOI = {10.1007/s00417-015-3262-1},
   year = {2016},
   type = {Journal Article}
}
Norbert Linz, Sebastian Freidank, Xiao-Xuan Liang, and Alfred Vogel,
Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery, American Physical Society,Phys. Rev. B , vol. 94, no. 2, pp. 1-19, 2016.
Datei: PhysRevB.94.024113
Bibtex: BibTeX
@article{Linz2016,
   author = {Linz, Norbert and Freidank, Sebastian and Liang, Xiao-Xuan and Vogel, Alfred},
   title = {Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery},
   journal = {American Physical Society,Phys. Rev. B},
   volume = { 94},
   number = {2},
   pages = {1-19},
   url = {http://link.aps.org/doi/10.1103/PhysRevB.94.024113},
   year = {2016},
   type = {Journal Article}
}
Mahdy Ranjbar, Max Philipp Brinkmann, Aysegül Tura, Martin Rudolf, Yoko Miura, and Salvatore Grisanti,
Ranibizumab interacts with the VEGF-A/VEGFR-2 signaling pathway in human RPE cells at different levels, Cytokine , vol. 83, pp. 210-216, 2016.
Datei: S1043466616300722
Bibtex: BibTeX
@article{Ranjbar2016,
   author = {Ranjbar, Mahdy and Brinkmann, Max Philipp and Tura, Aysegül and Rudolf, Martin and Miura, Yoko and Grisanti, Salvatore},
   title = {Ranibizumab interacts with the VEGF-A/VEGFR-2 signaling pathway in human RPE cells at different levels},
   journal = {Cytokine},
   volume = {83},
   pages = {210-216},
   abstract = {Vascular endothelial growth factor (VEGF) secreted by the retinal pigment epithelium (RPE) plays an important role in ocular homeostasis, but also in diseases, most notably age-related macular degeneration (AMD). To date, anti-VEGF drugs like ranibizumab have been shown to be most effective in treating these pathologic conditions. However, clinical trials suggest that the RPE could degenerate and perish through anti-VEGF treatment. Herein, we evaluated possible pathways and outcomes of the interaction between ranibizumab and human RPE cells (ARPE-19). Results indicate that ranibizumab affects the VEGF-A metabolism in RPE cells from an extra- as well as intracellular site. The drug is taken up into the cells, with the VEGF receptor 2 (VEGFR-2) being involved, and decreases VEGF-A protein levels within the cells as well as extracellularly. Oxidative stress plays a key role in various inflammatory disorders of the eye. Our results suggest that oxidative stress inhibits RPE cell proliferation. This anti-proliferative effect on RPE cells is significantly enhanced through ranibizumab, which does not inhibit RPE cell proliferation substantially in absence of relevant oxidative stress. Therefore, we emphasize that anti-VEGF treatment should be selected carefully in AMD patients with preexistent extensive RPE atrophy.},
   keywords = {Ranibizumab
RPE
VEGF-A
VEGFR-2
Oxidative stress},
   ISSN = {1043-4666},
   url = {http://www.sciencedirect.com/science/article/pii/S1043466616300722},
   year = {2016},
   type = {Journal Article}
}
Mario Pieper, Hinnerk Schulz-Hildebrandt, M. Mall, Gereon Hüttmann, and Peter König,
Intravital microscopy of mucus transport in mice provides mechanistic insight into hypertonic saline treatment of Cystic Fibrosis, Pneumologie , vol. 70, no. 07, pp. SOP2, 2016.
DOI:10.1055/s-0036-1584654
Bibtex: BibTeX
@article{Pieper2016,
   author = {Pieper, M. and Schulz-Hildebrandt, H. and Mall, M. and Hüttmann, G. and König, P.},
   title = {Intravital microscopy of mucus transport in mice provides mechanistic insight into hypertonic saline treatment of Cystic Fibrosis},
   journal = {Pneumologie},
   volume = {70},
   number = {07},
   pages = {SOP2},
   ISSN = {0934-8387},
   DOI = {10.1055/s-0036-1584654},
   year = {2016},
   type = {Journal Article}
}
Jens Horstmann, S. Siebelmann, I. Glasunow, A. Schadschneider, and Gereon Hüttmann,
OCT verstehen – Teil 1: Physikalische Grundlagen, Augenheilkunde up2date , vol. 6, no. 04, pp. 289-300, 2016.
DOI:10.1055/s-0042-113337
Bibtex: BibTeX
@article{Horstmann2016,
   author = {Horstmann, J. and Siebelmann, S. and Schulz-Hildebrandt, H. and Glasunow, I. and Schadschneider, A. and Hüttmann, G.},
   title = {OCT verstehen – Teil 1: Physikalische Grundlagen},
   journal = {Augenheilkunde up2date},
   volume = {6},
   number = {04},
   pages = {289-300},
   ISSN = {1616-9719},
   DOI = {10.1055/s-0042-113337},
   year = {2016},
   type = {Journal Article}
}
Kerstin Schlott, Stefan Koinzer, Alexander Baade, Johann Roider, and Ralf Brinkmann,
Lesion strength control by automatic temperature guided retinal photocoagulation, Journal of Biomedical Optics , vol. 21, no. 9, pp. 098001-098001, 2016.
DOI:10.1117/1.JBO.21.9.098001
Bibtex: BibTeX
@article{Schlott2016,
   author = {Schlott, Kerstin and Koinzer, Stefan and Baade, Alexander and Birngruber, Reginald and Roider, Johann and Brinkmann, Ralf},
   title = {Lesion strength control by automatic temperature guided retinal photocoagulation},
   journal = {Journal of Biomedical Optics},
   volume = {21},
   number = {9},
   pages = {098001-098001},
   note = {10.1117/1.JBO.21.9.098001},
   abstract = {Abstract.  Laser photocoagulation is an established treatment for a variety of retinal diseases. However, when using the same irradiation parameter, the size and strength of the lesions are unpredictable due to unknown inter- and intraindividual optical properties of the fundus layers. The aim of this work is to investigate a feedback system to generate desired lesions of preselectable strengths by automatically controlling the irradiation time. Optoacoustics were used for retinal temperature monitoring. A 532-nm continuous wave Nd:YAG laser was used for photocoagulation. A 75-ns/523-nm Q-switched Nd:YLF laser simultaneously excited temperature-dependent pressure transients, which were detected at the cornea by an ultrasonic transducer embedded in a contact lens. The temperature data were analyzed during the irradiation by a LabVIEW routine. The treatment laser was switched off automatically when the required lesion strength was achieved. Five different feedback control algorithms for different lesion sizes were developed and tested on rabbits in vivo. With a laser spot diameter of 133  μm, five different lesion types with ophthalmoscopically visible diameters ranging mostly between 100 and 200  μm, and different appearances were achieved by automatic exposure time control. The automatically controlled lesions were widely independent of the treatment laser power and the retinal pigmentation.},
   ISSN = {1083-3668},
   DOI = {10.1117/1.JBO.21.9.098001},
   year = {2016},
   type = {Journal Article}
}
Sijia Wang, Gereon Hüttmann, Florian Rudnitzki, Heyke Diddens-Tschoeke, Zhenxi Zhang, and Ramtin Rahmanzadeh,
Indocyanine green as effective antibody conjugate for intracellular molecular targeted photodynamic therapy, Journal of Biomedical Optics , vol. 21, no. 7, pp. 078001-078001, 2016.
DOI:10.1117/1.JBO.21.7.078001
Bibtex: BibTeX
@article{Wang2016,
   author = {Wang, Sijia and Hüttmann, Gereon and Rudnitzki, Florian and Diddens-Tschoeke, Heyke and Zhang, Zhenxi and Rahmanzadeh, Ramtin},
   title = {Indocyanine green as effective antibody conjugate for intracellular molecular targeted photodynamic therapy},
   journal = {Journal of Biomedical Optics},
   volume = {21},
   number = {7},
   pages = {078001-078001},
   note = {10.1117/1.JBO.21.7.078001},
   abstract = {Abstract.  The fluorescent dye indocyanine green (ICG) is clinically approved and has been applied for ophthalmic and intraoperative angiography, measurement of cardiac output and liver function, or as contrast agent in cancer surgery. Though ICG is known for its photochemical effects, it has played a minor role so far in photodynamic therapy or techniques for targeted protein-inactivation. Here, we investigated ICG as an antibody-conjugate for the selective inactivation of the protein Ki-67 in the nucleus of cells. Conjugates of the Ki-67 antibody TuBB-9 with different amounts of ICG were synthesized and delivered into HeLa and OVCAR-5 cells through conjugation to the nuclear localization sequence. Endosomal escape of the macromolecular antibodies into the cytoplasm was optically triggered by photochemical internalization with the photosensitizer BPD. The second light irradiation at 690 nm inactivated Ki-67 and subsequently caused cell death. Here, we show that ICG as an antibody-conjugate can be an effective photosensitizing agent. Best effects were achieved with 1.8 ICG molecules per antibody. Conjugated to antibodies, the ICG absorption peaks vary proportionally with concentration. The absorption of ICG above 650 nm within the optical window of tissue opens the possibility of selective Ki-67 inactivation deep inside of tissues.},
   ISSN = {1083-3668},
   year = {2016},
   type = {Journal Article}
}
Dierck Hillmann, Hendrik Spahr, Clara Pfäffle, Helge Sudkamp, Gesa Franke, and Gereon Hüttmann,
In vivo optical imaging of physiological responses to photostimulation in human photoreceptors, PNAS Early Edition , pp. 1-6, 2016.
Datei: 1606428113.abstract
Bibtex: BibTeX
@article{Hillmann2016,
   author = {Hillmann, Dierck and Spahr, Hendrik and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon},
   title = {In vivo optical imaging of physiological responses to photostimulation in human photoreceptors},
   journal = {PNAS Early Edition},
   pages = {1-6},
   abstract = {Noninvasive functional imaging of molecular and cellular processes of vision may have immense impact on research and clinical diagnostics. Although suitable intrinsic optical signals (IOSs) have been observed ex vivo and in immobilized animals in vivo, detecting IOSs of photoreceptor activity in living humans was cumbersome and time consuming. Here, we observed clear spatially and temporally resolved changes in the optical path length of the photoreceptor outer segment as a response to an optical stimulus in the living human eye. To witness these changes, we evaluated phase data obtained with a parallelized and computationally aberration-corrected optical coherence tomography system. The noninvasive detection of optical path length changes shows neuronal photoreceptor activity of single cones in living human retina, and therefore, it may provide diagnostic options in ophthalmology and neurology and could provide insights into visual phototransduction in humans.},
   url = {http://www.pnas.org/content/early/2016/10/10/1606428113.abstract},
   year = {2016},
   type = {Journal Article}
}
Mahdy Ranjbar, Max Philipp Brinkmann, Dorinja Zapf, Yoko Miura, Salvatore Grisanti, and Martin Rudolf,
Fc Receptor Inhibition Reduces Susceptibility to Oxidative Stress in Human RPE Cells Treated with Bevacizumab, but not Aflibercept, Cell Physiol Biochem , vol. 38, no. 2, pp. 737-47, 2016.
DOI:10.1159/000443030
Bibtex: BibTeX
@article{Ranjbar2016,
   author = {Ranjbar, M. and Brinkmann, M. P. and Zapf, D. and Miura, Y. and Rudolf, M. and Grisanti, S.},
   title = {Fc Receptor Inhibition Reduces Susceptibility to Oxidative Stress in Human RPE Cells Treated with Bevacizumab, but not Aflibercept},
   journal = {Cell Physiol Biochem},
   volume = {38},
   number = {2},
   pages = {737-47},
   note = {1421-9778
Ranjbar, Mahdy
Brinkmann, Max Philipp
Zapf, Dorinja
Miura, Yoko
Rudolf, Martin
Grisanti, Salvatore
Journal Article
Switzerland
Cell Physiol Biochem. 2016;38(2):737-47. doi: 10.1159/000443030. Epub 2016 Feb 15.},
   abstract = {BACKGROUND/AIMS: VEGF-A is induced by oxidative stress, and functions as a survival factor for various cell types, including retinal pigment epithelial (RPE) cells. Anti-vascular endothelial growth factor (VEGF) drugs like aflibercept and bevacizumab have shown to be most effective in treating neovascular age-related macular degeneration (AMD), however uptake of the drugs might lead to interference with cell physiology. Herein, we evaluated the significance of the Fc receptor (FcR) within this context and moreover explored the impact of VEGF inhibition under normal conditions as well as under oxidative stress, in terms of potential adverse effects. METHODS: ARPE-19 (human RPE) cells were treated with aflibercept and bevacizumab in presence or absence of H2O2 as oxidative stress stimulus. After 24h cells were evaluated for drug uptake, VEGF-A expression and secretion, levels of intracellular reactive oxygen species (ROS) as well as cell proliferation. Experiments were repeated with cells being pre-incubated with an FcR inhibitor prior to drug application. RESULTS: Both drugs inhibited extracellular levels of VEGF-A and were taken up into the RPE, resulting in significantly reduced intracellular levels of VEGF-A. When oxidative stress was applied, intracellular ROS levels in cells treated with both drugs rose, and cell proliferation was reduced. Prior incubation with the FcR inhibitor lessened the uptake of bevacizumab, but not aflibercept into RPE cells, and simultaneously enhanced cell survival under oxidative stress conditions. CONCLUSIONS: Our results indicate that uptake and accumulation of aflibercept and bevacizumab within RPE cells affect the intracellular VEGF-A metabolism negatively, leading to a biologically relevant reduced cell survival under oxidative stress. The FcR plays a substantial role in the uptake of bevacizumab, but not aflibercept, which allows an enhanced RPE cell survival through FcR blockage in an environment dominated by oxidative stress, as clinically significant for various inflammatory retinal disorders.},
   ISSN = {1015-8987},
   DOI = {10.1159/000443030},
   year = {2016},
   type = {Journal Article}
}
Regina Maushagen, Stefan Reers, Ann-Christin Pfannerstill, Angelina Hahlbrock, Roland Stauber, Ramtin Rahmanzadeh, Dirk Rades, Ralph Pries, and Barbara Wollenberg,
Effects of paclitaxel on permanent head and neck squamous cell carcinoma cell lines and identification of anti-apoptotic caspase 9b, J Cancer Res Clin Oncol , vol. 142, no. 6, pp. 1261--71, 2016.
DOI:10.1007/s00432-016-2150-3
Bibtex: BibTeX
@article{Maushagen2016,
   title        = {Effects of paclitaxel on permanent head and neck squamous cell carcinoma cell lines and identification of anti-apoptotic caspase 9b},
   author       = {Maushagen, R. and Reers, S. and Pfannerstill, A. C. and Hahlbrock, A. and Stauber, R. and Rahmanzadeh, R. and Rades, D. and Pries, R. and Wollenberg, B.},
   year         = 2016,
   journal      = {J Cancer Res Clin Oncol},
   volume       = 142,
   number       = 6,
   pages        = {1261--71},
   doi          = {10.1007/s00432-016-2150-3},
   issn         = {0171-5216},
   note         = {1432-1335 Maushagen, Regina Reers, Stefan Pfannerstill, Ann-Christin Hahlbrock, Angelina Stauber, Roland Rahmanzadeh, Ramtin Rades, Dirk Pries, Ralph Wollenberg, Barbara Journal Article Germany J Cancer Res Clin Oncol. 2016 Jun;142(6):1261-71. doi: 10.1007/s00432-016-2150-3. Epub 2016 Apr 1.},
   abstract     = {PURPOSE: Paclitaxel is an effective chemotherapeutic agent against various human tumors inducing apoptosis via binding to beta-tubulin of microtubules and arresting cells mainly in the G2/M phase of the cell cycle. However, the underlying specific molecular mechanisms of paclitaxel on head and neck squamous cell carcinoma (HNSCC) have not been identified yet. METHODS: The apoptotic effects and mechanisms of paclitaxel on different permanent HPV-negative HNSCC cell lines (UT-SCC-24A, UT-SCC-24B, UT-SCC-60A and UT-SCC-60B) were determined by flow cytometry assays, polymerase chain reaction analysis, immunofluorescence-based assays and sequencing studies. RESULTS: Paclitaxel induced a G2/M arrest in HNSCC cell lines followed by an increased amount of apoptotic cells. Moreover, the activation of caspase 8, caspase 10 and caspase 3, and the loss of the mitochondrial outer membrane potential could be observed, whereas an activation of caspase 9 could barely be detected. The efficient activation of caspase 9 was not affected by altered methylation patterns. Our results can show that the promoter region of apoptotic protease activating factor 1 (Apaf-1) was not methylated in the HNSCC cell lines. By sequencing analysis two isoforms of caspase 9, the pro-apoptotic caspase 9 and the anti-apoptotic caspase 9b were identified. The anti-apoptotic caspase 9b is missing the catalytic site and acts as an endogenous inhibitor of apoptosis by blocking the binding of caspase 9 to Apaf-1 to form the apoptosome. CONCLUSION: Our data indicate the presence of anti-apoptotic caspase 9b in HNSCC, which may serve as a promising target to increase chemotherapeutic apoptosis induction.},
   keywords     = {Apoptosis Caspase 9b Caspases Head and neck cancer Paclitaxel},
   type         = {Journal Article}
}
B. J. Tromberg, R. R. Anderson, M. W. Berns, J. A. Parrish, and G. Apiou-Sbirlea,
Biomedical optics centers: forty years of multidisciplinary clinical translation for improving human health, J Biomed Opt , vol. 21, no. 12, pp. 124001, 2016.
DOI:10.1117/1.JBO.21.12.124001
Bibtex: BibTeX
@article{RN5040,
   author = {Tromberg, B. J. and Anderson, R. R. and Birngruber, R. and Brinkmann, R. and Berns, M. W. and Parrish, J. A. and Apiou-Sbirlea, G.},
   title = {Biomedical optics centers: forty years of multidisciplinary clinical translation for improving human health},
   journal = {J Biomed Opt},
   volume = {21},
   number = {12},
   pages = {124001},
   ISSN = {1560-2281 (Electronic)
1083-3668 (Linking)},
   DOI = {10.1117/1.JBO.21.12.124001},
  
   year = {2016},
   type = {Journal Article}
}
Dierck Hillmann, Hendrik Spahr, Carola Hain, Helge Sudkamp, Gesa Franke, Clara Pfäffle, Christian Winter, and Gereon Hüttmann,
Aberration-free volumetric high-speed imaging of in vivo retina, Scientific Reports , vol. 6, pp. 1-11, 2016.
Datei: srep35209
Bibtex: BibTeX
@article{Hillmann2016,
   author = {Hillmann, Dierck and Spahr, Hendrik and Hain, Carola and Sudkamp, Helge and Franke, Gesa and Pfäffle, Clara and Winter, Christian and Hüttmann, Gereon},
   title = {Aberration-free volumetric high-speed imaging of in vivo retina},
   journal = {Scientific Reports},
   volume = {6},
   pages = {1-11},
   url = {http://dx.doi.org/10.1038/srep35209},
   year = {2016},
   type = {Journal Article}
}
Sijia Wang, Gereon Hüttmann, Thomas Scholzen, Zhenxi Zhang, Alfred Vogel, Tayyaba Hasan, and Ramtin Rahmanzadeh,
A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67, Sci Rep , vol. 6, pp. 27032, 2016.
DOI:10.1038/srep27032
Bibtex: BibTeX
@article{Wang2016,
   author = {Wang, S. and Huttmann, G. and Scholzen, T. and Zhang, Z. and Vogel, A. and Hasan, T. and Rahmanzadeh, R.},
   title = {A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67},
   journal = {Sci Rep},
   volume = {6},
   pages = {27032},
   note = {2045-2322
Wang, Sijia
Huttmann, Gereon
Scholzen, Thomas
Zhang, Zhenxi
Vogel, Alfred
Hasan, Tayyaba
Rahmanzadeh, Ramtin
Journal Article
England
Sci Rep. 2016 Jun 1;6:27032. doi: 10.1038/srep27032.},
   abstract = {Using nanotechnology for optical manipulation of molecular processes in cells with high spatial and temporal precision promises new therapeutic options. Especially tumor therapy may profit as it requires a combination of both selectivity and an effective cell killing mechanism. Here we show a dual targeting approach for selective and efficient light-controlled killing of cells which are positive for epidermal growth factor receptor (EGFR) and Ki-67. Liposomes with the covalently linked EGFR antibody Erbitux enabled selective uptake of FITC-labeled Ki-67 antibody TuBB-9 in EGFR-positive cells pre-loaded with the photoactive dye BPD. After irradiation at 690 nm, BPD disrupted the endosomal membranes and delivered the antibodies to the nucleoli of the cells. The second irradiation at 490 nm activated the FITC-labeled TuBB-9, which caused inactivation of the Ki-67 protein and subsequent cell death via apoptosis. Efficient cell killing was possible at nanomolar concentrations of TuBB-9 due to the effective transport by immune liposomes and the high efficacy of the Ki-67 light-inactivation. Delivery of the liposomal constructs and cell destruction correlated well with the EGFR expression pattern of different cell lines (HeLa, OVCAR-5, MCF-7, and human fibroblasts), demonstrating an excellent selectivity.},
   ISSN = {2045-2322},
   DOI = {10.1038/srep27032},
   year = {2016},
   type = {Journal Article}
}
Tianshi Wang, Tom Pfeiffer, Evelyn Regar, Wolfgang Wieser, Heleen van Beusekom, Charles T. Lancee, Geert Springeling, Ilona Krabbendam-Peters, Antonius F. W. van der Steen, Robert Huber, and Gijs van Soest,
Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy, JACC: Cardiovascular Imaging , vol. 9, no. 5, pp. 622-623, 2016.
DOI:10.1016/j.jcmg.2015.08.010
Bibtex: BibTeX
@article{WANG2016622,
title = {Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy},
journal = {JACC: Cardiovascular Imaging},
volume = {9},
number = {5},
pages = {622-623},
year = {2016},
issn = {1936-878X},
doi = {https://doi.org/10.1016/j.jcmg.2015.08.010},
url = {https://www.sciencedirect.com/science/article/pii/S1936878X15006713},
author = {Tianshi Wang and Tom Pfeiffer and Evelyn Regar and Wolfgang Wieser and Heleen {van Beusekom} and Charles T. Lancee and Geert Springeling and Ilona Krabbendam-Peters and Antonius F.W. {van der Steen} and Robert Huber and Gijs {van Soest}}
}

2015

Tianshi Wang, Tom Pfeiffer, Evelyn Regar, Wolfgang Wieser, Heleen van Beusekom, Charles T. Lancee, Geert Springeling, Ilona Krabbendam, Antonius F. W. van der Steen, Robert Huber, and Gijs van Soest,
Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography, Biomed. Opt. Express , vol. 6, no. 12, pp. 5021-5032, Dez. 2015. Optica Publishing Group.
DOI:10.1364/BOE.6.005021
Bibtex: BibTeX
@article{Wang:15,
author = {Tianshi Wang and Tom Pfeiffer and Evelyn Regar and Wolfgang Wieser and Heleen van Beusekom and Charles T. Lancee and Geert Springeling and Ilona Krabbendam and Antonius F.W. van der Steen and Robert Huber and Gijs van Soest},
journal = {Biomed. Opt. Express},
keywords = {Fiber optics imaging; Three-dimensional image acquisition; Medical optics instrumentation; Scanners; Endoscopic imaging; Medical and biological imaging; Optical coherence tomography; Image quality; Image registration; Imaging techniques; Laser modes; Mode locking; Optical coherence tomography},
number = {12},
pages = {5021--5032},
publisher = {Optica Publishing Group},
title = {Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography},
volume = {6},
month = {Dec},
year = {2015},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-6-12-5021},
doi = {10.1364/BOE.6.005021},
abstract = {Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called \&\#x201C;Heartbeat OCT\&\#x201D;, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s and 100 mm/s pullback speed, and with a commercial system. The in vivo results show that Heartbeat OCT provides faithfully rendered, motion-artifact free, fully sampled vessel wall architecture, unlike the conventional IV-OCT data. We present the Heartbeat OCT system in full technical detail and discuss the steps needed for clinical translation of the technology.},
}
Hendrik Spahr, Dierck Hillmann, Carola Hain, Clara Pfäffle, Helge Sudkamp, Gesa Franke, and Gereon Hüttmann,
Imaging pulse wave propagation in human retinal vessels using full-field swept-source optical coherence tomography, Optics Letters , vol. 40, no. 20, pp. 4771-4774, Okt. 2015.
DOI:10.1364/OL.40.004771
Datei: abstract.cfm
Bibtex: BibTeX
@article{Spahr2015,
   author = {Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon},
   title = {Imaging pulse wave propagation in human retinal vessels using full-field swept-source optical coherence tomography},
   journal = {Optics Letters},
   volume = {40},
   number = {20},
   pages = {4771-4774},
   abstract = {We demonstrate a new noninvasive method to assess biomechanical properties of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. The motion of retinal tissue that is induced by expansion of the vessels therein is measured with an accuracy of about 10 nm. The pulse shapes of arterial and venous pulsations, their temporal delays, as well as the frequency-dependent pulse propagation through the capillary bed, are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.},
   keywords = {Optical coherence tomography
Ophthalmology
Time-resolved imaging
Functional monitoring and imaging},
   DOI = {10.1364/OL.40.004771},
   url = {http://ol.osa.org/abstract.cfm?URI=ol-40-20-4771},
   year = {2015},
   type = {Journal Article}
}
Kathrin J. Mohler, Wolfgang Draxinger, Thomas Klein, Jan Philip Kolb, Wolfgang Wieser, Christos Haritoglou, Anselm Kampik, James G. Fujimoto, Aljoscha Neubauer, Armin Wolf, and Robert Huber,
Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm60° High-Definition MHz-OCT Imaging of the Choroid, Investigative Ophthalmology & Visual Science , vol. 56, no. 11, pp. 6284--6293, Okt. 2015.
DOI:10.1167/iovs.15-16670
Bibtex: BibTeX
@article{10.1167/iovs.15-16670,
    author = {Mohler, Kathrin J. and Draxinger, Wolfgang and Klein, Thomas and Kolb, Jan Philip and Wieser, Wolfgang and Haritoglou, Christos and Kampik, Anselm and Fujimoto, James G. and Neubauer, Aljoscha S. and Huber, Robert and Wolf, Armin},
    title = "{Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm}",
    journal = {Investigative Ophthalmology & Visual Science},
    volume = {56},
    number = {11},
    pages = {6284-6293},
    year = {2015},
    month = {10},
    abstract = "{   To demonstrate ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s for choroidal imaging in normal and diseased eyes over a ∼60° field of view. To investigate and correlate wide-field three-dimensional (3D) choroidal thickness (ChT) and vascular patterns using ChT maps and coregistered high-definition en face images extracted from a single densely sampled Megahertz-OCT (MHz-OCT) dataset.    High-definition, ∼60° wide-field 3D datasets consisting of 2088 × 1024 A-scans were acquired using a 1.68 MHz prototype SS-OCT system at 1050 nm based on a Fourier-domain mode-locked laser. Nine subjects (nine eyes) with various chorioretinal diseases or without ocular pathology are presented. Coregistered ChT maps, choroidal summation maps, and depth-resolved en face images referenced to either the retinal pigment epithelium or the choroidal–scleral interface were generated using manual segmentation.    Wide-field ChT maps showed a large inter- and intraindividual variance in peripheral and central ChT. In only four of the nine eyes, the location with the largest ChT was coincident with the fovea. The anatomy of the large lumen vessels of the outer choroid seems to play a major role in determining the global ChT pattern. Focal ChT changes with large thickness gradients were observed in some eyes.    Different ChT and vascular patterns could be visualized over ∼60° in patients for the first time using OCT. Due to focal ChT changes, a high density of thickness measurements may be favorable. High-definition depth-resolved en face images are complementary to cross sections and thickness maps and enhance the interpretation of different ChT patterns.  }",
    issn = {1552-5783},
    doi = {10.1167/iovs.15-16670},
    url = {https://doi.org/10.1167/iovs.15-16670},
    eprint = {https://arvojournals.org/arvo/content\_public/journal/iovs/934564/i1552-5783-56-11-6284.pdf},
}
Heyke C. Diddens-Tschoeke, Gereon Hüttmann, Achim D. Gruber, Roy H. Pottier, and Henning Hanken,
Localized thermal tumor destruction using dye-enhanced photothermal tumor therapy, Lasers in Surgery and Medicine , pp. n/a-n/a, 09 2015.
DOI:10.1002/lsm.22356
Datei: lsm.22356
Bibtex: BibTeX
@article{Diddens-Tschoeke2015,
   author = {Diddens-Tschoeke, Heyke C. and Hüttmann, Gereon and Gruber, Achim D. and Pottier, Roy H. and Hanken, Henning},
   title = {Localized thermal tumor destruction using dye-enhanced photothermal tumor therapy},
   journal = {Lasers in Surgery and Medicine},
   pages = {n/a-n/a},
   keywords = {photothermal therapy
naphthalocyanine derivative
in-vivo
laser
dye-enhanced},
   ISSN = {1096-9101},
   DOI = {10.1002/lsm.22356},
   url = {http://dx.doi.org/10.1002/lsm.22356},
   year = {2015},
   type = {Journal Article}
}

Lukas Reznicek, Jan Philip Kolb, Thomas Klein, Kathrin J. Mohler, Wolfgang Wieser, Robert Huber, Marcus Kernt, Josef Märtz, and Aljoscha Neubauer,
Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy, Journal of Diabetes Research , vol. 2015, pp. 305084, 07 2015. Hindawi Publishing Corporation.
DOI:10.1155/2015/305084
Bibtex: BibTeX
@article{Reznicek2015,
   author = {Reznicek, Lukas and Kolb, Jan P. and Klein, Thomas and Mohler, Kathrin J. and Wieser, Wolfgang and Huber, Robert and Kernt, Marcus and Märtz, Josef and Neubauer, Aljoscha S.},
   title = {Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy},
   journal = {Journal of Diabetes Research},
   volume = {2015, Article ID 305084},
   pages = {1-5},
   DOI = {10.1155/2015/305084},
   url = {http://dx.doi.org/10.1155/2015/305084},
   year = {2015},
keywords = {AG-Huber_OCT},
   type = {Journal Article}

}

Hinnerk Schulz-Hildebrandt, Mario Pieper, Peter König, and Gereon Hüttmann,
Improved endoscopic optical coherence microscopy for imaging of humans airways in patients, Pneumologie , vol. 69, no. 07, pp. A49, Jul. 2015.
DOI:10.1055/s-0035-1556641
Bibtex: BibTeX
@article{Schulz-Hildebrandt2015,
   author = {Schulz-Hildebrandt, H. and Pieper, M. and König, P. and Hüttmann, G.},
   title = {Improved endoscopic optical coherence microscopy for imaging of humans airways in patients},
   journal = {Pneumologie},
   volume = {69},
   number = {07},
   pages = {A49},
   ISSN = {0934-8387},
   DOI = {10.1055/s-0035-1556641},
   year = {2015},
   type = {Journal Article}
}
Christian Jirauschek, and Robert Huber,
Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers, Biomed. Opt. Express , vol. 6, no. 7, pp. 2448-2465, 07 2015. Optica Publishing Group.
DOI:10.1364/BOE.6.002448
Bibtex: BibTeX
@article{Jirauschek:15,
author = {Christian Jirauschek and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Laser theory; Lasers, tunable; Optical coherence tomography; Vertical cavity surface emitting lasers; Distributed Bragg reflectors; Laser light; Laser sources; Quantum well lasers; Swept lasers; Vertical cavity surface emitting lasers},
number = {7},
pages = {2448--2465},
publisher = {Optica Publishing Group},
title = {Wavelength shifting of intra-cavity photons: Adiabatic wavelength tuning in rapidly wavelength-swept lasers},
volume = {6},
month = {Jul},
year = {2015},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-6-7-2448},
doi = {10.1364/BOE.6.002448},
abstract = {We analyze the physics behind the newest generation of rapidly wavelength tunable sources for optical coherence tomography (OCT), retaining a single longitudinal cavity mode during operation without repeated build up of lasing. In this context, we theoretically investigate the currently existing concepts of rapidly wavelength-swept lasers based on tuning of the cavity length or refractive index, leading to an altered optical path length inside the resonator. Specifically, we consider vertical-cavity surface-emitting lasers (VCSELs) with microelectromechanical system (MEMS) mirrors as well as Fourier domain mode-locked (FDML) and Vernier-tuned distributed Bragg reflector (VT-DBR) lasers. Based on heuristic arguments and exact analytical solutions of Maxwell's equations for a fundamental laser resonator model, we show that adiabatic wavelength tuning is achieved, i.e., hopping between cavity modes associated with a repeated build up of lasing is avoided, and the photon number is conserved. As a consequence, no fundamental limit exists for the wavelength tuning speed, in principle enabling wide-range wavelength sweeps at arbitrary tuning speeds with narrow instantaneous linewidth.},
}
Robert Huber,
4-D Real-Time Optical Coherence Tomography, Opt. Photon. News , vol. 26, no. 6, pp. 32-39, 06 2015. Optica Publishing Group.
DOI:10.1364/OPN.26.6.000032
Bibtex: BibTeX
@article{Huber:15,
author = {Robert Huber},
journal = {Opt. Photon. News},
keywords = {Image processing; Optical coherence tomography; Lasers, tunable; Medical optics and biotechnology; Optical coherence tomography; Image processing; Imaging techniques; Line scan cameras; Medical imaging; Optical coherence tomography; Three dimensional imaging},
number = {6},
pages = {32--39},
publisher = {Optica Publishing Group},
title = {4-D Real-Time Optical Coherence Tomography},
volume = {26},
month = {Jun},
year = {2015},
url = {https://www.optica-opn.org/abstract.cfm?URI=opn-26-6-32},
doi = {10.1364/OPN.26.6.000032},
abstract = {Advances in OCT techniques, combined with the processing power of moderncomputer hardware, are adding a new dimension---time---to a familiar 3-D imaging method.The result could be new applications in research and the biomedicalclinic.},
}
Jan Philip Kolb, Thomas Klein, Corinna L. Kufner, Wolfgang Wieser, Aljoscha Neubauer, and Robert Huber,
Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle, Biomed. Opt. Express , vol. 6, no. 5, pp. 1534--1552, 05 2015. Optica Publishing Group.
DOI:10.1364/BOE.6.001534
Bibtex: BibTeX
@article{Kolb:15,
author = {Jan Philip Kolb and Thomas Klein and Corinna L. Kufner and Wolfgang Wieser and Aljoscha S. Neubauer and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Medical optics instrumentation; Lasers, fiber; Medical and biological imaging; Ophthalmic optics and devices ; Optical coherence tomography; Adaptive optics; Full field optical coherence tomography; Image quality; Imaging techniques; Laser scanning; Three dimensional imaging},
number = {5},
pages = {1534--1552},
publisher = {Optica Publishing Group},
title = {Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle},
volume = {6},
month = {May},
year = {2015},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-6-5-1534},
doi = {10.1364/BOE.6.001534},
abstract = {We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85{\textdegree} FOV as well as with 100{\textdegree} and stitching of five 60{\textdegree} images to a 100{\textdegree} mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused by the wide FOV are discussed and solutions to most issues are presented. Detailed information on the design and characterization of our sample arm optics is given. We investigate the origin of an angle dependent signal fall-off which we observe towards larger imaging angles. It is present in our 85{\textdegree} and 100{\textdegree} single volume images, but not in the mosaic. Our results suggest that 100{\textdegree} FOV OCT is possible with current swept source OCT technology.},
}
Christian Jirauschek, and Robert Huber,
Modeling and analysis of polarization effects in Fourier domain mode-locked lasers, Opt. Lett. , vol. 40, no. 10, pp. 2385-2388, 05 2015. Optica Publishing Group.
DOI:10.1364/OL.40.002385
Bibtex: BibTeX
@article{Jirauschek:15,
author = {Christian Jirauschek and Robert Huber},
journal = {Opt. Lett.},
keywords = {Laser theory; Lasers, tunable; Optical coherence tomography; Birefringence; Polarization; Pulses; Cross phase modulation; Mode locking; Optical components; Picosecond pulses; Polarization mode dispersion; Pulse generation},
number = {10},
pages = {2385--2388},
publisher = {Optica Publishing Group},
title = {Modeling and analysis of polarization effects in Fourier domain mode-locked lasers},
volume = {40},
month = {May},
year = {2015},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-40-10-2385},
doi = {10.1364/OL.40.002385},
abstract = {We develop a theoretical model for Fourier domain mode-locked (FDML) lasers in a non-polarization-maintaining configuration, which is the most widely used type of FDML source. This theoretical approach is applied to analyze a widely wavelength-swept FDML setup, as used for picosecond pulse generation by temporal compression of the sweeps. We demonstrate that good agreement between simulation and experiment can only be obtained by including polarization effects due to fiber bending birefringence, polarization mode dispersion, and cross-phase modulation into the theoretical model. Notably, the polarization dynamics are shown to have a beneficial effect on the instantaneous linewidth, resulting in improved coherence and thus compressibility of the wavelength-swept FDML output.},
}
Sebastian Karpf, Matthias Eibl, Wolfgang Wieser, Thomas Klein, and Robert Huber,
A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy, Nature Communications , vol. 6, no. 1, pp. 6784, 04 2015.
DOI:10.1038/ncomms7784
Bibtex: BibTeX
@Article{HU_2015_Karpf_a,
  Title                    = {A Time-Encoded Technique for fibre-based hyperspectral broadband stimulated Raman microscopy},
  Author                   = {Karpf, Sebastian and Eibl, Matthias and Wieser, Wolfgang and Klein, Thomas and Huber, Robert},
  Journal                  = {Nature Communications},
  Year                     = {2015},
  Volume = {6},
  pages = {6784 1--6},
keywords = {AG-Huber_NL},
  Doi                      = {10.1038/ncomms7784}
}
Gabriela Apiou-Sbirlea, Guillermo J. Tearney, Tayyaba Hasan, and Richard Rox Anderson,
Anatomy and physiology of translation: the academic research imperative, Clinical Investigation , vol. 5, no. 10, pp. 797-804, 2015.
DOI:10.4155/cli.15.46
Bibtex: BibTeX
@article{Apiou-Sbirlea2015,
   author = {Apiou-Sbirlea, Gabriela and Tearney, Guillermo J. and Birngruber, Reginald and Hasan, Tayyaba and Anderson, Richard Rox},
   title = {Anatomy and physiology of translation: the academic research imperative},
   journal = {Clinical Investigation},
   volume = {5},
   number = {10},
   pages = {797-804},
   ISSN = {2041-6792},
   DOI = {10.4155/cli.15.46},
   year = {2015},
   type = {Journal Article}
}
J Horstmann,
Speckle-based off-axis holographic detection for non-contact photoacoustic tomography, Current Directions in Biomedical Engineering , vol. 1, pp. 356-360, 2015.
Bibtex: BibTeX
@article{Buj2015,
   author = {Buj, C and Horstmann, J and Münter, M and Brinkman, R},
   title = {Speckle-based off-axis holographic detection for non-contact photoacoustic tomography},
   journal = {Current Directions in Biomedical Engineering},
   volume = {1},
   pages = {356-360},
   year = {2015},
   type = {Journal Article}
}
C. J. Niu, C. Fisher, K. Scheffler, R. Wan, H. Maleki, H. Liu, Y. Sun, C. A. Simmons, and L. Lilge,
Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells, Journal of Biomedical Optics , vol. 20(9), pp. 098002, 2015.
DOI:10.1117/1.JBO.20.9.098002
Bibtex: BibTeX
@article{Niu2015,
   author = {Niu, C. J. and Fisher, C. and Scheffler, K. and Wan, R. and Maleki, H. and Liu, H. and Sun, Y. and A. Simmons, C. and Birngruber, R. and Lilge, L.},
   title = {Polyacrylamide gel substrates that simulate the mechanical stiffness of normal and malignant neuronal tissues increase protoporphyin IX synthesis in glioma cells},
   journal = {Journal of Biomedical Optics},
   volume = {20(9)},
   Year = { 2015},
   DOI = {10.1117/1.JBO.20.9.098002},
  
   type = {Journal Article}
}
Young Gun Park, Seungbum Kang, Ralf Brinkmann, and Young-Jung Roh,
A Comparative Study of Retinal Function in Rabbits after Panretinal Selective Retina Therapy versus Conventional Panretinal Photocoagulation, Journal of Ophthalmology , vol. 2015, pp. 8, 2015.
DOI:10.1155/2015/247259
Datei: 247259
Bibtex: BibTeX
@article{Park2015,
   author = {Park, Young Gun and Kang, Seungbum and Brinkmann, Ralf and Roh, Young-Jung},
   title = {A Comparative Study of Retinal Function in Rabbits after Panretinal Selective Retina Therapy versus Conventional Panretinal Photocoagulation},
   journal = {Journal of Ophthalmology},
   volume = {2015},
   pages = {8},
   DOI = {10.1155/2015/247259},
   url = {http://dx.doi.org/10.1155/2015/247259},
   year = {2015},
   type = {Journal Article}
}
Norbert Linz, Sebastian Freidank, Xiao-Xuan Liang, Hannes Vogelmann, Thomas Trickl, and Alfred Vogel,
Wavelength dependence of nanosecond infrared laser-induced breakdown in water: Evidence for multiphoton initiation via an intermediate state, Physical Review B , vol. 91, no. 13, pp. 134114, 2015.
DOI:doi/10.1103/PhysRevB.91.134114
Datei: PhysRevB.91.134114
Bibtex: BibTeX
@article{Linz2015,
   author = {Linz, Norbert and Freidank, Sebastian and Liang, Xiao-Xuan and Vogelmann, Hannes and Trickl, Thomas and Vogel, Alfred},
   title = {Wavelength dependence of nanosecond infrared laser-induced breakdown in water: Evidence for multiphoton initiation via an intermediate state},
   journal = {Physical Review B},
   volume = {91},
   number = {13},
   pages = {134114},
   note = {PRB},
   DOI = {doi/10.1103/PhysRevB.91.134114},
   url = {http://link.aps.org/doi/10.1103/PhysRevB.91.134114},
   year = {2015},
   type = {Journal Article}
}
Patrick Steiner, Andreas Ebneter, Lieselotte Erika Berger, Martin Zinkernagel, Boris Považay, Christoph Meier, Jens H. Kowal, Carsten Framme, Ralf Brinkmann, Sebastian Wolf, and Raphael Sznitman,
Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina TherapyTime-Resolved Ultra–High Resolution OCT During SRT, Investigative Ophthalmology & Visual Science , vol. 56, no. 11, pp. 6654-6662, 2015.
DOI:10.1167/iovs.15-17151
Bibtex: BibTeX
@article{Steiner2015,
   author = {Steiner, Patrick and Ebneter, Andreas and Berger, Lieselotte Erika and Zinkernagel, Martin and Považay, Boris and Meier, Christoph and Kowal, Jens H. and Framme, Carsten and Brinkmann, Ralf and Wolf, Sebastian and Sznitman, Raphael},
   title = {Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina TherapyTime-Resolved Ultra–High Resolution OCT During SRT},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {56},
   number = {11},
   pages = {6654-6662},
   note = {10.1167/iovs.15-17151},
   abstract = {Abstract Purpose: Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods: An experimental OCT system with an ultra-high axial resolution of 1.78 μm was combined with an SRT system and time-resolved OCT M-scans of the target area were recorded from four patients undergoing SRT. Optical coherence tomography scans were analyzed and OCT morphology was correlated with findings in fluorescein angiography, fundus photography, and cross-sectional OCT. Results: In cases in which the irradiation caused RPE damage proven by fluorescein angiography, the lesions were well discernible in time-resolved OCT images but remained invisible in fundus photography and cross-sectional OCT acquired after treatment. If RPE damage was introduced, all applied SRT pulses led to detectable signal changes in the time-resolved OCT images. The extent of optical signal variation seen in the OCT data appeared to scale with the applied SRT pulse energy. Conclusions: The first clinical results proved that successful SRT irradiation induces detectable changes in the OCT M-scan signal while it remains invisible in conventional ophthalmoscopic imaging. Thus, real-time high-resolution OCT is a promising modality to monitor and analyze tissue effects introduced by selective retina therapy and may be used to guide SRT in an automatic feedback mode (www.swissmedic.ch number, 2011-MD-0006).},
   ISSN = {1552-5783},
   DOI = {10.1167/iovs.15-17151},
   year = {2015},
   type = {Journal Article}
}
S. Koinzer, K. Schlott, C. Hesse, A. Caliebe, and J. Roider,
Temperature-Controlled Retinal Photocoagulation Reliably Generates Uniform Subvisible, Mild, or Moderate Lesions, Transl Vis Sci Technol , vol. 4, no. 5, pp. 9, 2015.
DOI:10.1167/tvst.4.5.9
Bibtex: BibTeX
@article{Koinzer2015,
   author = {Koinzer, S. and Baade, A. and Schlott, K. and Hesse, C. and Caliebe, A. and Roider, J. and Brinkmann, R.},
   title = {Temperature-Controlled Retinal Photocoagulation Reliably Generates Uniform Subvisible, Mild, or Moderate Lesions},
   journal = {Transl Vis Sci Technol},
   volume = {4},
   number = {5},
   pages = {9},
   note = {Koinzer, Stefan
Baade, Alexander
Schlott, Kerstin
Hesse, Carola
Caliebe, Amke
Roider, Johann
Brinkmann, Ralf
Journal article
Transl Vis Sci Technol. 2015 Oct 6;4(5):9. eCollection 2015 Oct.},
   abstract = {PURPOSE: Conventional retinal photocoagulation produces irregular lesions and does not allow reliable control of ophthalmoscopically invisible lesions. We applied automatically controlled retinal photocoagulation, which allows to apply uniform lesions without titration, and aimed at five different predictable lesion intensities in a study on rabbit eyes. METHODS: A conventional 532-nm photocoagulation laser was used in combination with a pulsed probe laser. They facilitated real-time fundus temperature measurements and automatic exposure time control for different predefined time/temperature dependent characteristics (TTC). We applied 225 control lesions (exposure time 200 ms) and 794 TTC lesions (5 intensities, exposure times 7-800 ms) in six rabbit eyes with variable laser power (20-66.4 mW). Starting after 2 hours, we examined fundus color and optical coherence tomographic (OCT) images over 3 months and classified lesion morphologies according to a seven-stage OCT classifier. RESULTS: Visibility rates in funduscopy (OCT) after 2 hours were 17% (68%) for TTC intensity group 1, 38% (90%) for TTC group 2 and greater than 94% (>98%) for all consecutive groups. TTC groups 1 through 4 correlated to increasing morphological lesion intensities and increasing median funduscopic and OCT diameters. Group 5 lesions were as large as, but more intense than group 4 lesions. CONCLUSIONS: Automatic, temperature controlled photocoagulation allows to apply predictable subvisible, mild, or moderate lesions without manual power titration. TRANSLATIONAL RELEVANCE: The technique will facilitate standardized, automatically controlled low and early treatment of diabetic retinopathy study (ETDRS) intensity photocoagulation independently of the treating physician, the treated eye and lesion location.},
   keywords = {Oct
animal model
laser photocoagulation
optoacoustics
real-time temperature measurement
spectral domain
sub-visible},
   ISSN = {2164-2591 (Print)
2164-2591},
   DOI = {10.1167/tvst.4.5.9},
   year = {2015},
   type = {Journal Article}
}
J. Cordes,
Stone/tissue differentiation for holmium laser lithotripsy using autofluorescence, Lasers Surg Med , vol. 47, no. 9, pp. 737-44, 2015.
DOI:10.1002/lsm.22418
Bibtex: BibTeX
@article{Lange2015,
   author = {Lange, B. and Cordes, J. and Brinkmann, R.},
   title = {Stone/tissue differentiation for holmium laser lithotripsy using autofluorescence},
   journal = {Lasers Surg Med},
   volume = {47},
   number = {9},
   pages = {737-44},
   note = {1096-9101
Lange, Birgit
Cordes, Jens
Brinkmann, Ralf
Journal Article
United States
Lasers Surg Med. 2015 Nov;47(9):737-44. doi: 10.1002/lsm.22418. Epub 2015 Sep 22.},
   abstract = {BACKGROUND AND OBJECTIVES: Holmium laser lithotripsy is a safe and effective method to disintegrate urinary stones of all compositions in an endoscopic procedure. However, handling and safety could be improved by a real-time feedback system permanently monitoring the position of the treatment fiber. The laser is fired only when the fiber is identified as being placed in front of stone. This work evaluates the potential of fluorescence detection with an excitation wavelength of 532 nm for this purpose. MATERIALS AND METHODS: A fiber-based fluorescence measurement was set-up to acquire autofluorescence signals from several human renal calculi, artificial stones, and porcine tissue samples (renal calix and ureter). Three different approaches were investigated. First, experiments were performed with a pulsed laser source with a wavelength of 532 nm, pulse energy 36.5 +/- 1 muJ, pulse duration 1.2 +/- 0.5 nanoseconds, and a repetition rate of 1 kHz with 15 urinary concretions. In the second step, a series of measurements on 42 human urinary calculi samples was carried out using low power continuous wave excitation of 0.4 +/- 0.1 mW. Fluorescence was also measured simultaneously to stone fragmentation by holmium laser pulses (pulse energy 240 +/- 50 mJ, repetition rate 10 Hz). Finally, a modulated excitation/detection scheme (lock-in technique) was implemented to render fluorescence detection insensitive to white background light. RESULTS: Unlike porcine renal calix, ureter, and artificial stone human urinary calculi show a strong fluorescence signal when excited with 532 nm. With pulsed excitation on urinary stone (20,000 +/- 11,000) counts were registered at 587 nm with the CCD-array of a grating spectrometer in an integration time of 50 milliseconds. Tissue gave lower count rates of </=(5,500 +/- 1,100) even with longer integration times (500 milliseconds/1 second). With a cw excitation power of 0.4 mW (13,000 +/- 11,000) counts were registered in an integration time of 200 milliseconds at 587 nm (porcine renal calix: (770 +/- 340)). Modulated excitation (66 Hz) with an average power of 0.3 mW and detection with a photodiode resulted in a lock-in amplifier signal of 1.5-4.3V on stone (background and skin: <0.5V). CONCLUSION: With the lock-in technique, autofluorescence from stones can be detected with only the average excitation power of a green aiming beam overlaid to the Ho:YAG-laser beam (power </= 1 mW). Since tissue shows very little autofluorescence when excited with 532 nm, this fluorescence signal enables monitoring of the correct position of the treatment fiber during ureteroscopic procedures. Lasers Surg. Med. 47:737-744, 2015. (c) 2015 Wiley Periodicals, Inc.},
   keywords = {Holmium laser
feedback control
fluorescence
laser lithotripsy},
   ISSN = {0196-8092},
   DOI = {10.1002/lsm.22418},
   year = {2015},
   type = {Journal Article}
}
C. Framme, A. Walter, L. Berger, P. Prahs, and C. Alt,
Selective Retina Therapy in Acute and Chronic-Recurrent Central Serous Chorioretinopathy, Ophthalmologica , vol. 234, no. 4, pp. 177-88, 2015.
DOI:10.1159/000439188
Bibtex: BibTeX
@article{Framme2015,
   author = {Framme, C. and Walter, A. and Berger, L. and Prahs, P. and Alt, C. and Theisen-Kunde, D. and Kowal, J. and Brinkmann, R.},
   title = {Selective Retina Therapy in Acute and Chronic-Recurrent Central Serous Chorioretinopathy},
   journal = {Ophthalmologica},
   volume = {234},
   number = {4},
   pages = {177-88},
   note = {1423-0267
Framme, Carsten
Walter, Andreas
Berger, Lieselotte
Prahs, Philipp
Alt, Clemens
Theisen-Kunde, Dirk
Kowal, Jens
Brinkmann, Ralf
Journal Article
Research Support, Non-U.S. Gov't
Switzerland
Ophthalmologica. 2015;234(4):177-88. doi: 10.1159/000439188. Epub 2015 Sep 15.},
   abstract = {PURPOSE: Selective retina therapy (SRT), the confined laser heating and destruction of retinal pigment epithelial cells, has been shown to treat acute types of central serous chorioretinopathy (CSC) successfully without damaging the photoreceptors and thus avoiding laser-induced scotoma. However, a benefit of laser treatment for chronic forms of CSC is questionable. In this study, the efficacy of SRT by means of the previously used 1.7-micros and shorter 300-ns pulse duration was evaluated for both types of CSC, also considering re-treatment for nonresponders. MATERIAL AND METHODS: In a two-center trial, 26 patients were treated with SRT for acute (n = 10) and chronic-recurrent CSC (n = 16). All patients presented with subretinal fluid (SRF) in OCT and leakage in fluorescein angiography (FA). SRT was performed using a prototype SRT laser system (frequency-doubled Q-switched Nd:YLF-laser, wavelength 527 nm) with adjustable pulse duration. The following irradiation settings were used: a train of 30 laser pulses with a repetition rate of 100 Hz and pulse durations of 300 ns and 1.7 micros, pulse energy 120-200 microJ, retinal spot size 200 microm. Because SRT lesions are invisible, FA was always performed 1 h after treatment to demonstrate laser outcome (5-8 single spots in the area of leakage). In cases where energy was too low, as indicated by missing FA leakage, energy was adjusted and the patient re-treated immediately. Observation intervals were after 4 weeks and 3 months. In case of nonimprovement of the disease after 3 months, re-treatment was considered. RESULTS: Of 10 patients with active CSC that presents focal leakage in FA, 5 had completely resolved fluid after 4 weeks and all 10 after 3 months. Mean visual acuity increased from 76.6 ETDRS letters to 85.0 ETDRS letters 3 months after SRT. Chronic-recurrent CSC was characterized by less severe SRF at baseline in OCT and weaker leakage in FA than in acute types. Visual acuity changed from baseline 71.6 to 72.8 ETDRS letters after 3 months. At this time, SRF was absent in 3 out of 16 patients (19%), FA leakage had come to a complete stop in 6 out of 16 patients (38%). In 6 of the remaining chronic CSC patients, repeated SRT with higher pulse energy was considered because of persistent leakage activity. After the re-treatment, SRF resolved completely in 5 patients (83.3%) after only 25 days. CONCLUSION: SRT showed promising results in treating acute CSC, but was less effective in chronic cases. Interestingly, re-treatment resulted in enhanced fluid resolution and dry conditions after a considerably shorter time in most patients. Therefore, SRT including re-treatment if necessary might be a valuable CSC treatment alternative even in chronic-recurrent cases.},
   ISSN = {0030-3755},
   DOI = {10.1159/000439188},
   year = {2015},
   type = {Journal Article}
}
Antje Klinger, L. Krapf, Regina Orzekowsky-Schröder, Norbert Koop, Alfred Vogel, and Gereon Hüttmann,
Intravital autofluorescence 2-photon microscopy of murine intestinal mucosa with ultra-broadband femtosecond laser pulse excitation: image quality, photodamage, and inflammation, J Biomed Opt , vol. 20, no. 11, pp. 116001, 2015.
DOI:10.1117/1.jbo.20.11.116001
Bibtex: BibTeX
@article{Klinger2017,
   author = {Klinger, A. and Krapf, L. and Orzekowsky-Schroeder, R. and Koop, N. and Vogel, A. and Huttmann, G.},
   title = {Intravital autofluorescence 2-photon microscopy of murine intestinal mucosa with ultra-broadband femtosecond laser pulse excitation: image quality, photodamage, and inflammation},
   journal = {J Biomed Opt},
   volume = {20},
   number = {11},
   pages = {116001},
   ISSN = {1083-3668},
   DOI = {10.1117/1.jbo.20.11.116001},
   year = {2015},
   type = {Journal Article}
}
Gereon Hüttmann, Stefan Otto Johannes Koinzer, Heike Muller, Iris Ellerkamp, Alexander Baade, Moritz Moltmann, Dirk Theisen-Kunde, Birgit Lange, Ralf Brinkmann, and Reginald Birngruber,
Predicting ophthalmoscopic visibility of retinal photocoagulation lesions byhigh-speedOCT: an animal studyinrabbits, Investigative Ophthalmology & Visual Science , vol. 56, no. 7, pp. 5980-5980, 2015. https://iovs.arvojournals.org/article.aspx?articleid=2336071 .
Weblink: https://iovs.arvojournals.org/article.aspx?articleid=2336071
Bibtex: BibTeX
@article{Hüttmann2015,
   author = {Huttmann, Gereon and Koinzer, Stefan Otto Johannes and Müller, Heike and Ellerkamp, Iris and Baade, Alex and Moltmann, Moritz and Theisen-Kunde, Dirk and Lange, Birgit and Brinkmann, Ralf and Birngruber, Reginald},
   title = {Predicting ophthalmoscopic visibility of retinal photocoagulation lesions byhigh-speedOCT: an animal studyinrabbits},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {56},
   number = {7},
   pages = {5980-5980},
   ISSN = {1552-5783},
   year = {2015},
   type = {Journal Article}
}
J. Horstmann, and M. Munter,
Full-field speckle interferometry for non-contact photoacoustic tomography, Phys Med Biol , vol. 60, no. 10, pp. 4045--58, 2015.
Bibtex: BibTeX
@article{Horstmann2015,
   title        = {Full-field speckle interferometry for non-contact photoacoustic tomography},
   author       = {Horstmann, J. and Spahr, H. and Buj, C. and Munter, M. and Brinkmann, R.},
   journal      = {Phys Med Biol},
   volume       = 60,
   number       = 10,
   pages        = {4045--58},
   note         = {1361-6560 abstract = {A full-field speckle interferometry method for non-contact and prospectively high speed Photoacoustic Tomography is introduced and evaluated as proof of concept. Thermoelastic pressure induced changes of the objects topography are acquired in a repetitive mode without any physical contact to the object. In order to obtain high acquisition speed, the object surface is illuminated by laser pulses and imaged onto a high speed camera chip. In a repetitive triple pulse mode, surface displacements can be acquired with nanometre sensitivity and an adjustable sampling rate of e.g. 20 MHz with a total acquisition time far below one second using kHz repetition rate lasers. Due to recurring interferometric referencing, the method is insensitive to thermal drift of the object due to previous pulses or other motion. The size of the investigated area and the spatial and temporal resolution of the detection are scalable. In this study, the approach is validated by measuring a silicone phantom and a porcine skin phantom with embedded silicone absorbers. The reconstruction of the absorbers is presented in 2D and 3D. The sensitivity of the measurement with respect to the photoacoustic detection is discussed. Potentially, Photoacoustic Imaging can be brought a step closer towards non-anaesthetized in vivo imaging and new medical applications not allowing acoustic contact, such as neurosurgical monitoring or burnt skin investigation.}, ISSN = {0031-9155}, DOI = {10.1088/0031-9155/60/10/4045}, year = {2015}, type = {Journal Article}}
}
H. D. Kim, Jung Woo Han, Y. H. Ohn, and T. K. Park,
Functional evaluation using multifocal electroretinogram after selective retina therapy with a microsecond-pulsed laser, Invest Ophthalmol Vis Sci , vol. 56, no. 1, pp. 122-31, 2015.
DOI:10.1167/iovs.14-15132
Bibtex: BibTeX
@article{Kim2015,
   author = {Kim, H. D. and Han, J. W. and Ohn, Y. H. and Brinkmann, R. and Park, T. K.},
   title = {Functional evaluation using multifocal electroretinogram after selective retina therapy with a microsecond-pulsed laser},
   journal = {Invest Ophthalmol Vis Sci},
   volume = {56},
   number = {1},
   pages = {122-31},
   note = {1552-5783
Kim, Hoon Dong
Han, Jung Woo
Ohn, Young-Hoon
Brinkmann, Ralf
Park, Tae Kwann
Journal Article
United States
Invest Ophthalmol Vis Sci. 2014 Dec 11;56(1):122-31. doi: 10.1167/iovs.14-15132.},
   abstract = {PURPOSE: To evaluate the changes of retinal function with multifocal electroretinogram (mfERG), and estimate the association between functional and structural changes after selective retina therapy (SRT) with microsecond-pulsed laser in comparison to continuous wave laser photocoagulation (cwPC). METHODS: Selective retina therapy and cwPC were applied with 10 x 10 shots and 1/2 lesion-width on the retina in the right and left eyes of 20 healthy Chinchilla Bastard rabbits, respectively. Optical coherence tomography (OCT), fundus fluorescein angiography (FFA), and mfERG were performed before, and on days 1, 7, and 30 after both laser treatments. The mean ratios of amplitudes and implicit times of N1 and P1 from eight hexagons covering laser-treated retinal lesions/total retina were measured. Histology was obtained after killing three rabbits at each time period to observe the anatomic changes after both laser treatments. RESULTS: The mean ratios of amplitudes of N1 and P1 in SRT lesions did not change significantly for 30 days after laser treatment. Only subtle reductions of the mean ratios of N1 and P1 amplitudes on day 1, thereafter the amplitudes showed the trend to recover toward baseline values. Histology and OCT revealed temporary and reversible morphologic changes after SRT, which restored to normal within 1 month. However, the mean ratios of N1 amplitudes on days 7 and 30 (P = 0.010, P < 0.001, respectively), and P1 amplitudes on days 7 and 30 (P < 0.001, P < 0.001, respectively) declined significantly in cwPC lesions compared with baseline. Disorganization and atrophic changes were identified on histology and OCT after cwPC. CONCLUSIONS: The results suggest that SRT preserved retinal function as well as anatomical structure after treatment.},
   keywords = {continuous wave laser photocoagulation (cwPC)
multifocal electroretinogram (mfERG)
selective retina therapy (SRT)},
   ISSN = {0146-0404},
   DOI = {10.1167/iovs.14-15132},
   year = {2015},
   type = {Journal Article}
}
Hendrik Spahr, Carola Hain, Helge Sudkamp, Gesa Franke, Dierck Hillmann, and Gereon Hüttmann,
Functional Microangiography of in vivo human retina by Full-Field OCT, Investigative Ophthalmology & Visual Science , vol. 56, no. 7, pp. 5974-5974, 2015. https://iovs.arvojournals.org/article.aspx?articleid=2336064 .
Weblink: https://iovs.arvojournals.org/article.aspx?articleid=2336064
Datei:
Bibtex: BibTeX
@article{Spahr2015,
   author = {Spahr, Hendrik and Hain, Carola and Sudkamp, Helge and Franke, Gesa and Hillmann, Dierck and Huttmann, Gereon},
   title = {Functional Microangiography of in vivo human retina by Full-Field OCT},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {56},
   number = {7},
   pages = {5974-5974},
   abstract = { PurposeOCT based functional microangiography of the retina requires high speed acquisition of a large number of volumetric datasets. Imaging speed of conventional scanning OCT devices is limited by the applicable radiant power and the mechanics used to scan the focused beam over the desired field of view. Full-Field Swept-Source OCT (FF-SS-OCT) resolves both issues, using an areal illumination, which dramatically increases the allowed amount of radiation, and an ultrafast camera for a highly parallelized acquisition.  MethodsThe retina of healthy volunteers was illuminated with wavelengths between 816 and 867 nm by the extended beam of a tunable laser (Broadsweeper, Superlum). Retinal irradiance was below the maximum permissable exposure (MPE). Light backscattered from the retina was imaged onto an ultrafast CMOS camera (SA-Z, Photron), where it interfered with an extended reference beam. From a series of interference images at different wavelengths, volumetric OCT images of the retina were reconstructed.  ResultsWe demonstrate in vivo retinal imaging at 9.9 billion voxels per second (40 million A-scans/s with 256 axial pixels). Sacrificing depth resolution by reducing the number of axial pixels, the A-scan rate was increased to more than 1 billion A-scans per second. FF-SS-OCT allowed imaging of all important retinal structures with good quality at unprecedented imaging speed (see fig. 1). Fast volumetric imaging at up to 3000 volumes/s was used to visualize small capillaries and to analyze the pulsation of retinal arteries and veins (see fig. 2). Imaging time for an area of 4 mm x 2 mm (896 x 368 A-scans) was only 316 µs. The high volume rate and the inherent phase stability enabled quantitative measurement of the change of retinal thickness due to blood pulsation with approx. 10 nm precision. A delay of the venous pulsation with respect to the arteries was observed (approx. 11 ms). The amplitudes of higher frequency components of the venous pulsation were considerably attenuated.  ConclusionsFF-SS-OCT provides fast volumetric imaging of the retina with good image quality. The capillary network can be analyzed with high spatial and temporal resolution. Analysis of retinal pulsation may provide information on pathological changes of vessels and capillaries. Angiographic OCT acquired with the FF-SS-OCT setup. Functional angiography showing the pulsation of retinal artery and vein.},
   ISSN = {1552-5783},
   url = {http://dx.doi.org/},
   year = {2015},
   type = {Journal Article}
}
Bing Han, Karsten Köhler, Kerstin Jungnickel, Robert Mettin, Werner Lauterborn, and Alfred Vogel,
Dynamics of laser-induced bubble pairs, Journal of Fluid Mechanics , vol. 771, pp. 706-742, 2015.
DOI:doi:10.1017/jfm.2015.183
Datei: jfm.2015.183
Bibtex: BibTeX
@article{Han2015,
   author = {Han, Bing and Köhler, Karsten and Jungnickel, Kerstin and Mettin, Robert and Lauterborn, Werner and Vogel, Alfred},
   title = {Dynamics of laser-induced bubble pairs},
   journal = {Journal of Fluid Mechanics},
   volume = {771},
   pages = {706-742},
   keywords = {bubble dynamics,cavitation,jets},
   ISSN = {1469-7645},
   DOI = {doi:10.1017/jfm.2015.183},
   url = {http://dx.doi.org/10.1017/jfm.2015.183},
   year = {2015},
   type = {Journal Article}
}
Livia Zarnescu, Michael C. Leung, Michael Abeyta, Helge Sudkamp, Thomas Baer, Barry Behr, and Audrey K. Ellerbee,
Label-free characterization of vitrification-induced morphology changes in single-cell embryos with full-field optical coherence tomography, Journal of Biomedical Optics , vol. 20, no. 9, pp. 096004-096004, 2015.
DOI:10.1117/1.JBO.20.9.096004
Datei: 1.JBO.20.9.096004
Bibtex: BibTeX
@article{Zarnescu2015,
   author = {Zarnescu, Livia and Leung, Michael C. and Abeyta, Michael and Sudkamp, Helge and Baer, Thomas and Behr, Barry and Ellerbee, Audrey K.},
   title = {Label-free characterization of vitrification-induced morphology changes in single-cell embryos with full-field optical coherence tomography},
   journal = {Journal of Biomedical Optics},
   volume = {20},
   number = {9},
   pages = {096004-096004},
   note = {10.1117/1.JBO.20.9.096004},
   abstract = {Abstract.  Vitrification is an increasingly popular method of embryo cryopreservation that is used in assisted reproductive technology. Although vitrification has high post-thaw survival rates compared to other freezing techniques, its long-term effects on embryo development are still poorly understood. We demonstrate an application of full-field optical coherence tomography (FF-OCT) to visualize the effects of vitrification on live single-cell (2 pronuclear) mouse embryos without harmful labels. Using FF-OCT, we observed that vitrification causes a significant increase in the aggregation of structures within the embryo cytoplasm, consistent with reports in literature based on fluorescence techniques. We quantify the degree of aggregation with an objective metric, the cytoplasmic aggregation (CA) score, and observe a high degree of correlation between the CA scores of FF-OCT images of embryos and of fluorescence images of their mitochondria. Our results indicate that FF-OCT shows promise as a label-free assessment of the effects of vitrification on embryo mitochondria distribution. The CA score provides a quantitative metric to describe the degree to which embryos have been affected by vitrification and could aid clinicians in selecting embryos for transfer.},
   ISSN = {1083-3668},
   DOI = {10.1117/1.JBO.20.9.096004},
   url = {http://dx.doi.org/10.1117/1.JBO.20.9.096004},
   year = {2015},
   type = {Journal Article}
}
Sijia Wang, Gereon Hüttmann, Zhenxi Zhang, Alfred Vogel, Reginald Birngruber, Shifalika Tangutoori, Tayyaba Hasan, and Ramtin Rahmanzadeh,
Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67, Mol Pharm , vol. 12, no. 9, pp. 3272-81, 2015.
DOI:10.1021/acs.molpharmaceut.5b00260
Bibtex: BibTeX
@article{Wang2015,
   author = {Wang, S. and Huttmann, G. and Zhang, Z. and Vogel, A. and Birngruber, R. and Tangutoori, S. and Hasan, T. and Rahmanzadeh, R.},
   title = {Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67},
   journal = {Mol Pharm},
   note = {1543-8392
Wang, Sijia
Huttmann, Gereon
Zhang, Zhenxi
Vogel, Alfred
Birngruber, Reginald
Tangutoori, Shifalika
Hasan, Tayyaba
Rahmanzadeh, Ramtin
Journal article
Mol Pharm. 2015 Aug 13.},
   abstract = {The selective inhibition of intracellular and nuclear molecules such as Ki-67 holds great promise for the treatment of cancer and other diseases. However, the choice of the target protein and the intracellular delivery of the functional agent remain crucial challenges. Main hurdles are (a) an effective delivery into cells, (b) endosomal escape of the delivered agents, and (c) an effective, externally triggered destruction of cells. Here we show a light-controlled two-step approach for selective cellular delivery and cell elimination of proliferating cells. Three different cell-penetrating nano constructs, including liposomes, conjugates with the nuclear localization sequence (NLS), and conjugates with the cell penetrating peptide Pep-1, delivered the light activatable antibody conjugate TuBB-9-FITC, which targets the proliferation associated protein Ki-67. HeLa cells were treated with the photosensitizer benzoporphyrin monoacid derivative (BPD) and the antibody constructs. In the first optically controlled step, activation of BPD at 690 nm triggered a controlled endosomal escape of the TuBB-9-FITC constructs. In more than 75% of Ki-67 positive, irradiated cells TuBB-9-FITC antibodies relocated within 24 h from cytoplasmic organelles to the cell nucleus and bound to Ki-67. After a second light irradiation at 490 nm, which activated FITC, cell viability decreased to approximately 13%. Our study shows an effective targeting strategy, which uses light-controlled endosomal escape and the light inactivation of Ki-67 for cell elimination. The fact that liposomal or peptide-assisted delivery give similar results leads to the additional conclusion that an effective mechanism for endosomal escape leaves greater variability for the choice of the delivery agent.},
   keywords = {endosomal entrapment
liposome
nanotechnology
nuclear localization sequence (NLS)
photodynamic therapy},
   ISSN = {1543-8384},
   DOI = {10.1021/acs.molpharmaceut.5b00260},
   year = {2015},
   type = {Journal Article}
}
Rehman Ansari, Christian Buj, Mario Pieper, Peter König, Achim Schweikard, and Gereon Hüttmann,
Micro-anatomical and functional assessment of ciliated epithelium in mouse trachea using optical coherence phase microscopy, Opt Express , vol. 23, no. 18, pp. 23217-24, 2015.
DOI:10.1364/oe.23.023217
Bibtex: BibTeX
@article{Ansari2015,
   author = {Ansari, R. and Buj, C. and Pieper, M. and Konig, P. and Schweikard, A. and Huttmann, G.},
   title = {Micro-anatomical and functional assessment of ciliated epithelium in mouse trachea using optical coherence phase microscopy},
   journal = {Opt Express},
   volume = {23},
   number = {18},
   pages = {23217-24},
   note = {1094-4087
Ansari, Rehman
Buj, Christian
Pieper, Mario
Konig, Peter
Schweikard, Achim
Huttmann, Gereon
Journal Article
United States
Opt Express. 2015 Sep 7;23(18):23217-24. doi: 10.1364/OE.23.023217.},
   abstract = {Motile cilia perform a range of important mechanosensory and chemosensory functions, along with expulsion of mucus and inhaled pathogens from the lungs. Here we demonstrate that spectral domain optical coherence phase microscopy (SD-OCPM), which combines the principles of optical coherence tomography (OCT) and confocal microscopy, is particularly well-suited for characterization of both morphology and the ciliary dynamics of mouse trachea. We present micro-anatomical images of mouse trachea, where different cell types can be clearly visualized. The phase contrast, which measures the sub-nanometer changes in axial optical pathlength is used to determine the frequency and direction of cilia beatings.},
   ISSN = {1094-4087},
   DOI = {10.1364/oe.23.023217},
   year = {2015},
   type = {Journal Article}
}
U. Gehlsen, Márta Szaszák, Andreas Gebert, Norbert Koop, Gereon Hüttmann, and Philipp Steven,
Non-Invasive Multi-Dimensional Two-Photon Microscopy enables optical fingerprinting (TPOF) of immune cells, Journal of Biophotonics , vol. 8, no. 6, pp. 466-479, 2015.
DOI:https://doi.org/10.1002/jbio.201400036
Datei: jbio.201400036
Bibtex: BibTeX
title = {Non-Invasive Multi-Dimensional Two-Photon Microscopy enables optical fingerprinting (TPOF) of immune cells},
journal = {Journal of Biophotonics},
volume = {8},
number = {6},
pages = {466-479},
keywords = {ocular surface, intravital two-photon microscopy, antigen presenting cells, in vivo, non invasive},
doi = {https://doi.org/10.1002/jbio.201400036},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201400036},
eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbio.201400036},
abstract = {Mucosal surfaces are constantly exposed to pathogens and show high immunological activity. In a broad variety of ocular surface disorders inflammation is common, but underlying mechanisms are often not fully understood. However, the main clinical problem is that inflammatory processes are difficult to characterize and quantify due to the impossibility of repeated tissue probing of the delicate ocular surface. Therefore non-invasive optical methods are thought to have the potential for intravital investigation of ocular surface inflammation. This study demonstrates the general potential of two-photon microscopy to non-invasively detect and discriminate key players of inflammation in the ocular surface by using intrinsic fluorescence-based features without the necessity of tissue probing or the use of dyes. The use of wavelength dependent measurements of fluorescence lifetime, in addition to autofluorescence intensity enables a functional differentiation of isolated immune cells in vitro at excitation wavelengths between 710 to 830 nm. Mixed cell cultures and first in vivo results indicate the use of excitation wavelength of 710 to 750 nm for further experiments and future use in patients. Two photon based autofluorescence features of immune cells enables non-invasive differentiation.},
year = {2015}
}

2014

Yaokun Zhang, Tom Pfeiffer, Marcel Weller, Wolfgang Wieser, Robert Huber, Jörg Raczkowsky, Jörg Schipper, Heinz Wörn, and Thomas Klenzner,
Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale, BioMed research international , vol. 2014, pp. 251814, 09 2014. Hindawi Publishing Corporation.
DOI:10.1155/2014/251814
Bibtex: BibTeX
@Article{HU_2014_Zhang_a,
  Title                    = {{Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale}},
  Author                   = {Zhang, Yaokun and Pfeiffer, Tom and Weller, Marcel and Wieser, Wolfgang and Huber, Robert and Raczkowsky, J\"{o}rg and Schipper, J\"{o}rg and W\"{o}rn, Heinz and Klenzner, Thomas},
  Journal                  = {BioMed research international},
  Year                     = {2014},
  Month                    = jan,
  Pages                    = {251814--24},
  Volume                   = {2014},
  Doi                      = {10.1155/2014/251814},
  ISSN                     = {2314-6141},
keywords = {AG-Huber_OCT},
  Url                      = {http://www.hindawi.com/journals/bmri/2014/251814/}
}
Wolfgang Wieser, Wolfgang Draxinger, Thomas Klein, Sebastian Karpf, Tom Pfeiffer, and Robert Huber,
High definition live 3D-OCT in vivo: design and evalution of 4D-OCT engine with 1 GVoxel/s, Biomed. Opt. Express , vol. 5, no. 9, pp. 2963--77, 09 2014. Optica Publishing Group.
DOI:10.1364/BOE.5.002963
Bibtex: BibTeX
@article{Wieser:14,
author = {Wolfgang Wieser and Wolfgang Draxinger and Thomas Klein and Sebastian Karpf and Tom Pfeiffer and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Optical coherence tomography; Lasers, tunable; Optical coherence tomography; Endoscopic imaging; Full field optical coherence tomography; Functional imaging; Image quality; Ophthalmic imaging; Vertical cavity surface emitting lasers},
number = {9},
pages = {2963--2977},
publisher = {Optica Publishing Group},
title = {High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s},
volume = {5},
month = {Sep},
year = {2014},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-5-9-2963},
doi = {10.1364/BOE.5.002963},
abstract = {We present a 1300 nm OCT system for volumetric real-time live OCT acquisition and visualization at 1 billion volume elements per second. All technological challenges and problems associated with such high scanning speed are discussed in detail as well as the solutions. In one configuration, the system acquires, processes and visualizes 26 volumes per second where each volume consists of 320 x 320 depth scans and each depth scan has 400 usable pixels. This is the fastest real-time OCT to date in terms of voxel rate. A 51 Hz volume rate is realized with half the frame number. In both configurations the speed can be sustained indefinitely. The OCT system uses a 1310 nm Fourier domain mode locked (FDML) laser operated at 3.2 MHz sweep rate. Data acquisition is performed with two dedicated digitizer cards, each running at 2.5 GS/s, hosted in a single desktop computer. Live real-time data processing and visualization are realized with custom developed software on an NVidia GTX 690 dual graphics processing unit (GPU) card. To evaluate potential future applications of such a system, we present volumetric videos captured at 26 and 51 Hz of planktonic crustaceans and skin.},
}
Sebastian Karpf, Matthias Eibl, Wolfgang Wieser, Thomas Klein, and Robert Huber,
Time-Encoded Raman: Fiber-based, hyperspectral, broadband stimulated Raman microscopy, ArXiv e-prints , 05 2014.
DOI:10.48550/arXiv.1405.4181
Bibtex: BibTeX
@Article{HU_2014_Karpf_a,
  Title                    = {{Time-Encoded Raman: Fiber-based, hyperspectral, broadband stimulated Raman microscopy}},
  Author                   = {Karpf, Sebastian and Eibl, Matthias and Wieser, Wolfgang and Klein, Thomas and Huber, Robert},
  journal = {ArXiv e-prints},
  Year                     = {2014},
  Archiveprefix            = {arXiv},
  Arxivid                  = {1405.4181},
  Eprint                   = {1405.4181},
keywords = {AG-Huber_NL},
  Url                      = {http://arxiv.org/abs/1405.4181}
}
Hisashi Iwami, Joachim Pruessner, Kunihiko Shiraki, Ralf Brinkmann, and Yoko Miura,
Protective effect of a laser-induced sub-lethal temperature rise on RPE cells from oxidative stress, Exp Eye Res , vol. 124c, pp. 37-47, Mai 2014.
DOI:10.1016/j.exer.2014.04.014
Bibtex: BibTeX
@article{Iwami2014,
   author = {Iwami, H. and Pruessner, J. and Shiraki, K. and Brinkmann, R. and Miura, Y.},
   title = {Protective effect of a laser-induced sub-lethal temperature rise on RPE cells from oxidative stress},
   journal = {Exp Eye Res},
   volume = {124c},
   pages = {37-47},
   note = {1096-0007
Iwami, Hisashi
Pruessner, Joachim
Shiraki, Kunihiko
Brinkmann, Ralf
Miura, Yoko
Journal article
Exp Eye Res. 2014 May 5;124C:37-47. doi: 10.1016/j.exer.2014.04.014.},
   abstract = {Recently introduced new technologies that enable temperature-controlled laser irradiation on the RPE allowed us to investigate temperature-resolved RPE cell responses. In this study we aimed primarily to establish an experimental setup that can realize laser irradiation on RPE cell culture with the similar temperature distribution as in the clinical application, with a precise time/temperature history. With this setup, we conducted investigations to elucidate the temperature-dependent RPE cell biochemical responses and the effect of transient hyperthermia on the responses of RPE cells to the secondary-exposed oxidative stress. Porcine RPE cells cultivated in a culture dish (inner diameter = 30 mm) with culture medium were used, on which laser radiation (lambda = 1940 nm, spot diameter = 30 mm) over 10 s was applied as a heat source. The irradiation provides a radially decreasing temperature profile which is close to a Gaussian shape with the highest temperature in the center. Power setting for irradiation was determined such that the peak temperature (Tmax) in the center of the laser spot at the cells reaches from 40 degrees C to 58 degrees C (40, 43, 46, 50, 58 degrees C). Cell viability was investigated with ethidium homodimer III staining at the time points of 3 and 24 h following laser irradiation. Twenty four hours after laser irradiation the cells were exposed to hydrogen peroxide (H2O2) for 5 h, followed by the measurement of intracellular glutathione, intracellular 4-hydroxynonenal (HNE) protein adducts, and secreted vascular endothelial growth factor (VEGF). The mean temperature threshold for RPE cell death after 3 h was found to be around 52 degrees C, and for 24 h around 50 degrees C with the current irradiation setting. A sub-lethal preconditioning on Tmax = 43 degrees C significantly induced the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio, and decreased H2O2-induced increase of intracellular 4-HNE protein adducts. Although sub-lethal hyperthermia (Tmax = 40 degrees C, 43 degrees C, and 46 degrees C) caused a slight increase of VEGF secretion in 6 h directly following irradiation, secondary exposed H2O2-induced VEGF secretion was significantly reduced in the sub-lethally preheated groups, where the largest effect was seen following the irradiation with Tmax = 43 degrees C. In summary, the current results suggest that sub-lethal thermal laser irradiation on the RPE at Tmax = 43 degrees C for 10 s enhances cell defense system against oxidative stress, with increasing the GSH/GSSG ratio. Together with the results that the decreased amount of H2O2-induced 4-HNE in sub-lethally preheated RPE cells was accompanied by the lower secretion of VEGF, it is also strongly suggested that the sub-lethal hyperthermia may modify RPE cell functionality to protect RPE cells from oxidative stress and associated functional decrease, which are considered to play a significant role in the pathogenesis of age-related macular degeneration and other chorioretinal degenerative diseases.},
   ISSN = {0014-4835},
   DOI = {10.1016/j.exer.2014.04.014},
   year = {2014},
   type = {Journal Article}
}
Lukas Reznicek, Thomas Klein, Wolfgang Wieser, Marcus Kernt, Armin Wolf, Christos Haritoglou, Anselm Kampik, Robert Huber, and Aljoscha Neubauer,
Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices., Graefe's Archive for Clinical and Experimental Ophthalmology , vol. 252, no. 6, pp. 1009-1016, 05 2014.
DOI:10.1007/s00417-014-2640-4
Bibtex: BibTeX
@Article{HU_2014_Reznicek_a,
  Title                    = {{Megahertz ultra-wide-field swept-source retina optical coherence tomography compared to current existing imaging devices.}},
  Author                   = {Reznicek, Lukas and Klein, Thomas and Wieser, Wolfgang and Kernt, Marcus and Wolf, Armin and Haritoglou, Christos and Kampik, Anselm and Huber, Robert and Neubauer, Aljoscha S},
  Journal                  = {Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv f\"{u}r klinische und experimentelle Ophthalmologie},
  Year                     = {2014},

  Month                    = jun,
  Number                   = {6},
  Pages                    = {1009--16},
  Volume                   = {252},

  Doi                      = {10.1007/s00417-014-2640-4},
  ISSN                     = {1435-702X},
keywords = {AG-Huber_OCT},
  Url                      = {http://link.springer.com/article/10.1007\%2Fs00417-014-2640-4}
}
Jan Philip Kolb, Thomas Klein, Kathrin J. Mohler, Wolfgang Wieser, Lukas Reznicek, Marcus Kernt, Anselm Kampik, Aljoscha Neubauer, and Robert Huber,
Widefield Megahertz (MHz) OCT of diabetic retinopathy, Investigative Ophthalmology & Visual Science , vol. 55, no. 13, pp. 5018, 04 2014.
Weblink: https://iovs.arvojournals.org/article.aspx?articleid=2270590
Bibtex: BibTeX
@article{Kolb2014,
   author = {Kolb, Jan Philip and Klein, Thomas and Mohler, Kathrin and Wieser, Wolfgang and Reznicek, Lukas and Kernt, Marcus and Kampik, Anselm and Neubauer, Aljoscha S. and Huber, Robert},
   title = {Widefield Megahertz (MHz) OCT of diabetic retinopathy},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {55},
   number = {13},
   pages = {5018-5018},
   abstract = { PurposeTo investigate morphological appearance of diabetic retinopathy and laser effects in panretinal laser photocoagulation with a widefield MHz OCT (60° field of view, 120° center angle).  MethodsA custom swept-source OCT device with a 1060nm Fourier-domain mode-locked laser source achieving a line rate of 1.68MHz was used to investigate 15 consecutive patients with diabetic retinopathy. Within 1.82s datasets consisting of 2088x1024 A-scans over 60° were acquired. The densely sampled three dimensional datasets were investigated in various B-Scan cross-sections as well as en-face images and 3D reconstructions. Selected findings were compared with SLO images from a widefield SLO (Optos, Dunfermeline, UK).  ResultsOn the densely sampled 3D and en-face images, hard exsudates, peripheral laser spots as well as proliferative neovascularization were readily detected. Characteristic structural changes resulting from laser burns could easily be visualized across the whole field of view in the OCT datasets. In addition, depth-scans and B-scans allowed to identify additional structural changes including IS/OS disruption, RPE detachment or neovascularisation reaching into the vitreous across the field of view.  ConclusionsThree dimensional visualization of the retina over 60° field of view with a MHz OCT is feasible in patients with diabetic retinopathy. It might allow additional clinical insights in peripheral changes such as laser spots or retinal neovascularisation. 3D reconstruction of OCT dataset of patient with diabetic retinopathy with neovascularization (green), hard exsudates (yellow), epiretinal membrane and peripheral retinal scars after panretinal laser treatment (blue). Indications with arrows are examplatory. Top: En-face of same patient as in figure 1. Red line indicates the position of B-Frame below. Retinal scars due to focal laser coagulation temporal of the fovea visible. Bottom: Neovascularisation (green) reaching into the vitreous is visible on the left side. Retinal scars especially on RPE level due to panretinal laser treatment (blue) are observable.},
   ISSN = {1552-5783},
   url = {http://dx.doi.org/},
   year = {2014},
keywords = {AG-Huber_OCT},
   type = {Journal Article}
}
Thomas Klein, Wolfgang Draxinger, Kathrin J. Mohler, Jan Philip Kolb, Wolfgang Wieser, Anselm Kampik, Aljoscha Neubauer, Armin Wolf, and Robert Huber,
Wide-field choroidal thickness and en-face maps of patients created with MHz-OCT, Investigative Ophthalmology & Visual Science , vol. 55, no. 13, pp. 1620, 04 2014.
Weblink: https://iovs.arvojournals.org/article.aspx?articleid=2266882
Bibtex: BibTeX
@article{Klein2014,
   author = {Klein, Thomas and Draxinger, Wolfgang and Mohler, Kathrin and Kolb, Jan Philip and Wieser, Wolfgang and Kampik, Anselm and Neubauer, Aljoscha S. and Wolf, Armin and Huber, Robert},
   title = {Wide-field choroidal thickness and en-face maps of patients created with MHz-OCT},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {55},
   number = {13},
   pages = {1620-1620},
   abstract = { PurposeTo study the feasibility of simultaneous peripheral and central choroidal thickness measurement and en-face visualization in patients with a variety of diseases, using a single high-resolution wide-field MHz-OCT dataset spanning more than 50 degrees field of view.  MethodsIn this retrospective study, choroidal morphology of 29 patients imaged with MHz-OCT was assessed. MHz-OCT is a custom SS-OCT operating at 1060nm and an axial line rate of 1.68MHz. The high speed, more than 30 times faster than current commercial devices, enabled a very high resolution scan protocol of 2088x1024 A-scans over a wide field of ~60 degrees. However, due to the very high speed, signal strength is lower compared to slower devices. Hence, thickness and structure maps were only created for selected datasets: The positions of Bruch’s membrane and choroid sclera junction were determined manually by a trained observer a subset of all A-scans, from which thickness and intensity maps were created.  ResultsDespite relative low signal strength, the choroid sclera junction could be clearly observed over the entire unshadowed image area in 15 of 29 patients. Apart from shadowing, visibility of this junction shows strong variation even within a single dataset due to varying retinal thickness, eye-blinks, saccades and retinal curvature. Thus, thickness could be evaluated at least in some areas for all 29 patients, especially in the periphery. Moreover, choroidal thickness varied considerably intra- and interindividually. In two patients, abrupt changes of the choroid were observed in the temporal periphery, which may resemble morphology or imaging artifact. In addition to thickness, en-face choroidal structure maps were extracted from the segmented OCT datasets. Visibility of choroidal vasculature in these maps correlates with choroidal thickness.  ConclusionsChoroidal thickness and structure in patients could be visualized over large areas for the first time. Due to focal choroidal thickness changes with large thickness gradients, high-density scan protocols may be favorable for OCT-based investigations of the choroid. En-face images of the choroid can be extracted from these high-resolution datasets, but the influence of choroidal thickness on the image information should be taken into account. Choroidal en-face image (top), color-coded thickness map with superimposed structural image (middle) and OCT B-frame (bottom) for two eyes (A,B).},
   ISSN = {1552-5783},
   url = {http://dx.doi.org/},
   year = {2014},
keywords = {AG-Huber_OCT},
   type = {Journal Article}
}
Karsten Ulrich Kortuem, Jan Philip Kolb, Thomas Klein, Kathrin J. Mohler, Anselm Kampik, Aljoscha Neubauer, Wolfgang Wieser, Robert Huber, and Christos Haritoglou,
Wide Field MHz OCT imaging of the vitreoretinal interface, Invest. Ophthalmol. Vis. Sci. , vol. 55, no. 13, pp. 1619, 04 2014.
Weblink: https://iovs.arvojournals.org/article.aspx?articleid=2266879
Bibtex: BibTeX
@article{Kortuem2014,
   author = {Kortuem, Karsten Ulrich and Kolb, Jan Philip and Klein, Thomas and Mohler, Kathrin and Kampik, Anselm and Neubauer, Aljoscha S. and Wieser, Wolfgang and Huber, Robert and Haritoglou, Christos},
   title = {Wide Field MHz OCT imaging of the vitreoretinal interface},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {55},
   number = {13},
   pages = {1619-1619},
   abstract = { PurposeTo investigate changes caused by vitreoretinal interface disease with a multi-MHz OCT over a wide field of view of 60°.  MethodsWe used custom swept-source OCT device with a 1060nm Fourier-domain mode-locked laser source achieving a line rate of 1.68MHz. Within 1.82s datasets consisting of 2088x1024 A-scans over 60° were acquired from 5 patients with vitreoretinal traction due to VMTS and 3 patients with vascular pathology. The densely sampled three dimensional datasets were investigated in B-Scan cross-sections as well as en-face images and 3D reconstructions.  ResultsVitreoretinal traction could be imaged well in most of the cases, although the current sensitivity of the system limited image quality. Across the whole 60° field of view in the OCT datasets vitreoretinal tractions could be topographically assessed, always including the macula and optic disc, where vitreous anchorage could be shown. By means of the depth-scans as part of the 3D OCT volume we could image traction-associated retinal changes such as retinal elevation or RPE detachment.  ConclusionsThis unique three dimensional visualization of the retina over 60° field of view with a MHz OCT is feasible in patients with vitreoretinal interface disease and might offer additional clinical insights on the three-dimensional topology of tractional changes. Three dimensional Wide Field MHz OCT retinal and vitreous visualization.},
   ISSN = {1552-5783},
   url = {http://dx.doi.org/},
   year = {2014},
keywords = {AG-Huber_OCT},
   type = {Journal Article}
}
Yoko Miura,
Retinal Laser Therapy: Recent Unique Developments Behind the Brilliant Front Stage of Anti-VEGF Treatment, J Clin Exp Ophthalmol , vol. 5, no. 6, pp. 1-2, 2014.
DOI:http://dx.doi.org/10.4172/2155-9570.1000e114
Bibtex: BibTeX
@article{Miura2014,
   author = {Yoko, Miura},
   title = {Retinal Laser Therapy: Recent Unique Developments Behind the Brilliant Front Stage of Anti-VEGF Treatment},
   journal = {J Clin Exp Ophthalmol},
   volume = {5},
   number = {6},
   pages = {1-2},
   note = {-},
   DOI = {http://dx.doi.org/10.4172/2155-9570.1000e114},
   year = {2014},
   type = {Journal Article}
}

M. Evers, L. Ha, D. Welford, and D. Manstein,
Wavelength-Dependence of Fractional Ablations in Biological Materials Using a Tunable Cr2+:Znse/S Infrared Laser, Lasers in Surgery and Medicine , vol. 46, pp. 38-39, 2014.
Datei: WOS:000333055800109
Bibtex: BibTeX
@article{Evers2014,
   author = {Evers, M. and Ha, L. and Welford, D. and Birngruber, R. and Manstein, D.},
   title = {Wavelength-Dependence of Fractional Ablations in Biological Materials Using a Tunable Cr2+:Znse/S Infrared Laser},
   journal = {Lasers in Surgery and Medicine},
   volume = {46},
   pages = {38-39},
   note = {Suppl. 25
Ad2hq
119
Times Cited:0
Cited References Count:0},
   ISSN = {0196-8092},
   url = {<Go to ISI>://WOS:000333055800109},
   year = {2014},
   type = {Journal Article}
}
Rehman Ansari, Christian Myrtus, Redouane Aherrahrou, Jeanette Erdmann, Achim Schweikard, and Gereon Hüttmann,
Ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy, Optics Letters , vol. 39, no. 1, pp. 45-47, 2014.
DOI:10.1364/OL.39.000045
Datei: abstract.cfm
Bibtex: BibTeX
@article{Ansari2014,
   author = {Ansari, Rehman and Myrtus, Christian and Aherrahrou, Redouane and Erdmann, Jeanette and Schweikard, Achim and Hüttmann, Gereon},
   title = {Ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy},
   journal = {Optics Letters},
   volume = {39},
   number = {1},
   pages = {45-47},
   abstract = {We present an ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy (SD-OCPM) system that combines submicrometer transverse spatial resolution and subnanometer optical path length sensitivity, with an acquisition speed of over 217,000&#x2009;&#x2009;voxels/s. The proposed SD-OCPM system overcomes two significant drawbacks of traditional common-path interferometers&#x2014;limited transverse spatial resolution and suboptimal detection sensitivity&#x2014;while maintaining phase stability that is comparable with common-path interferometer setups. The transverse and axial spatial resolution of the setup is measured to be 0.6 and 1.9&#xA0;&#x3BC;m, respectively, with a phase sensitivity of 0.0027&#xA0;rad (corresponds to optical path length sensitivity of 110&#xA0;pm). High-speed acquisition allows for phase-sensitive 4D imaging of biological samples with subcellular resolution.},
   keywords = {Microscopy
Coherence imaging
Three-dimensional microscopy},
   DOI = {10.1364/OL.39.000045},
   url = {http://ol.osa.org/abstract.cfm?URI=ol-39-1-45},
   year = {2014},
   type = {Journal Article}
}
Martin Rudolf, Armin Mir Mohi Sefat, Marie C. Dettbarn, Yoko Miura, Zouhair Aherrahrou, Mahdy Ranjbar, Bulent Mutus, and Johannes K.M. Knobloch,
Detection of esterified cholesterol in murine Bruch's membrane wholemounts with a perfringolysin O-based cholesterol marker, Invest Ophthalmol Vis Sci , vol. 55, no. 8, pp. 4759-67, 2014.
DOI:10.1167/iovs.14-14311
Bibtex: BibTeX
@article{Rudolf2014,
   author = {Rudolf, M. and Mohi, A. and Dettbarn, M. C. and Miura, Y. and Aherrahrou, Z. and Ranjbar, M. and Mutus, B. and Knobloch, J. K.},
   title = {Detection of esterified cholesterol in murine Bruch's membrane wholemounts with a perfringolysin O-based cholesterol marker},
   journal = {Invest Ophthalmol Vis Sci},
   volume = {55},
   number = {8},
   pages = {4759-67},
   note = {1552-5783
Rudolf, Martin
Mohi, Armin
Dettbarn, Marie C
Miura, Yoko
Aherrahrou, Zouhair
Ranjbar, Mahdy
Mutus, Bulent
Knobloch, Johannes K M
Journal Article
Research Support, Non-U.S. Gov't
United States
Invest Ophthalmol Vis Sci. 2014 Jul 1;55(8):4759-67. doi: 10.1167/iovs.14-14311.},
   abstract = {PURPOSE: To investigate the effects of Bruch's membrane (BrM) neutral lipid deposition in mouse models and its significance to aging and age-related macular degeneration, it is essential to reliably detect small quantities of neutral lipids including esterified cholesterol (EC). In chorioretinal sections and BrM wholemounts, we tested a novel fluorescent cholesterol marker based on the bacterial toxin perfringolysin O (PFO) and compared results with those obtained with the classic cholesterol dye filipin. METHODS: An engineered plasmid containing the specific cholesterol binding domain (D4) of PFO fused to green fluorescent protein (GFP) was expressed in cultured E. coli, isolated, purified, and concentrated. A total of 150 BrM-choroid wholemounts and chorioretinal sections of 11- to 13-month-old ApoE(null) mice were prepared and stained with PFO/D4-GFP or filipin for EC. Samples were examined by epifluorescence microscopy. RESULTS: The fluorescence intensity of PFO/D4-GFP was strong, stable, and, if small quantities of EC were present, superior to filipin. In all specimens, we could sharply locate the PFO/D4-GFP signal to BrM. A semiquantitative evaluation of BrM lipid deposition is possible by measuring PFO/D4-GFP fluorescence intensity. CONCLUSIONS: The use of PFO/D4-GFP allowed a robust and direct detection of EC in aged murine BrM. In wholemount samples, its strong and stable fluorescence facilitated a semiquantitative evaluation of BrM-EC content over a large area. The patterns of EC deposition in murine BrM wholemounts are comparable with findings in human BrM wholemounts. Perfringolysin O/D4-GFP could be an important tool for investigating the effects of BrM lipid deposition in mouse models.},
   keywords = {Aging/*metabolism/pathology
Animals
Bacterial Toxins
Bruch Membrane/*metabolism/ultrastructure
Cells, Cultured
Cholesterol Esters/*metabolism
Clostridium perfringens
Disease Models, Animal
Feasibility Studies
Female
Hemolysin Proteins/*diagnostic use
Humans
Macular Degeneration/*diagnosis/metabolism
Mice
Mice, Inbred C57BL
Microscopy, Electron, Transmission},
   ISSN = {0146-0404},
   DOI = {10.1167/iovs.14-14311},
   year = {2014},
   type = {Journal Article}
}
I. Rohde, J. M. Masch, M. Marczynski-Bühlow, R. Bombien Quaden, and G. Lutter,
Resection of Calcified Aortic Heart Leaflets In Vitro by Q-Switched 2 µm Microsecond Laser Radiation, Journal of Cardiac Surgery , vol. 30, no. 2, pp. 157-162, 2014.
DOI:10.1111/jocs.12481
Datei: jocs.12481
Bibtex: BibTeX
@article{Rohde2014,
   author = {Rohde, I. and Masch, J. M. and Theisen-Kunde, D. and Marczynski-Bühlow, M. and Bombien Quaden, R. and Lutter, G. and Brinkmann, R.},
   title = {Resection of Calcified Aortic Heart Leaflets In Vitro by Q-Switched 2 µm Microsecond Laser Radiation},
   journal = {Journal of Cardiac Surgery},
   volume = {30},
   number = {2},
   pages = {157-162},
   ISSN = {1540-8191},
   DOI = {10.1111/jocs.12481},
   url = {http://dx.doi.org/10.1111/jocs.12481},
   year = {2014},
   type = {Journal Article}
}
Stefan Koinzer, Amke Caliebe, Lea Portz, Mark Saeger, Yoko Miura, Kerstin Schlott, Ralf Brinkmann, and Johann Roider,
Comprehensive detection, grading, and growth behavior evaluation of subthreshold and low intensity photocoagulation lesions by optical coherence tomographic and infrared image analysis, Biomed Res Int , vol. 2014, pp. 492679, 2014.
DOI:10.1155/2014/492679
Datei: 492679
Bibtex: BibTeX
@article{Koinzer2014,
   title        = {Comprehensive detection, grading, and growth behavior evaluation of subthreshold and low intensity photocoagulation lesions by optical coherence tomographic and infrared image analysis},
   author       = {Koinzer, S. and Caliebe, A. and Portz, L. and Saeger, M. and Miura, Y. and Schlott, K. and Brinkmann, R. and Roider, J.},
   year         = 2014,
   journal      = {Biomed Res Int},
   volume       = 2014,
   pages        = 492679,
   doi          = {10.1155/2014/492679},
   url          = {http://dx.doi.org/10.1155/2014/492679},
   note         = {2314-6141 Koinzer, Stefan Caliebe, Amke Portz, Lea Saeger, Mark Miura, Yoko Schlott, Kerstin Brinkmann, Ralf Roider, Johann Journal Article Research Support, Non-U.S. Gov't United States Biomed Res Int. 2014;2014:492679. doi: 10.1155/2014/492679. Epub 2014 May 12.},
   abstract     = {PURPOSE: To correlate the long-term clinical effect of photocoagulation lesions after 6 months, as measured by their retinal damage size, to exposure parameters. We used optical coherence tomographic (OCT)-based lesion classes in order to detect and assess clinically invisible and mild lesions. METHODS: In this prospective study, 488 photocoagulation lesions were imaged in 20 patients. We varied irradiation diameters (100/300 microm), exposure-times (20-200 ms), and power. Intensities were classified in OCT images after one hour, and we evaluated OCT and infrared (IR) images over six months after exposure. RESULTS: For six consecutive OCT-based lesion classes, the following parameters increased with the class: ophthalmoscopic, OCT and IR visibility rate, fundus and OCT diameter, and IR area, but not irradiation power. OCT diameters correlated with exposure-time, irradiation diameter, and OCT class. OCT classes discriminated the largest bandwidth of OCT diameters. CONCLUSION: OCT classes represent objective and valid endpoints of photocoagulation intensity even for "subthreshold" intensities. They are suitable to calculate the treated retinal area. As the area is critical for treatment efficacy, OCT classes are useful to define treatment intensity, calculate necessary lesion numbers, and universally categorize lesions in clinical studies.},
   type         = {Journal Article}
}
Wolfgang Wieser, Wolfgang Draxinger, Thomas Klein, and Tom Pfeiffer,
A 4-D OCT Engine with 1 GVoxel/s, Optics and Photonics News , vol. 25, no. 12, pp. 36, 2014. OSA.
Weblink: https://www.optica-opn.org/home/articles/volume_25/december_2014/extras/a_4-d_oct_engine_with_1_gvoxel_s/#.VcH21Pl5raw
Bibtex: BibTeX
@Article{HU_2014_Wieser_b,
  Title                    = {{A 4-D OCT Engine with 1 GVoxel/s}},
  Author                   = {Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert},
  Journal                  = {Optics and Photonics News},
  Year                     = {2014},

  Month                    = dec,
  Number                   = {12},
  Pages                    = {36 },
  Volume                   = {25},
keywords = {AG-Huber_FDML, AG-Huber_OCT},

  Publisher                = {OSA},
  Url                      = { http://www.osa-opn.org/home/articles/volume_25/december_2014/extras/a_4-d_oct_engine_with_1_gvoxel_s/#.VcH21Pl5raw}
}
Philipp Steven, Carolin Le Blanc, Eva Lankenau, Marc Krug, Stefan Oelckers, Ludwig M Heindl, Uta Gehlsen, Gereon Hüttmann, and Claus Cursiefen,
Optimising deep anterior lamellar keratoplasty (DALK) using intraoperative online optical coherence tomography (iOCT), British Journal of Ophthalmology , vol. 98, no. 7, pp. 900--904, 2014. BMJ Publishing Group Ltd.
DOI:10.1136/bjophthalmol-2013-304585
Datei: 900
Bibtex: BibTeX
@article {Steven900,
	author = {Philipp Steven and Carolin Le Blanc and Eva Lankenau and Marc Krug and Stefan Oelckers and Ludwig M Heindl and Uta Gehlsen and Gereon Huettmann and Claus Cursiefen},
	title = {Optimising deep anterior lamellar keratoplasty (DALK) using intraoperative online optical coherence tomography (iOCT)},
	volume = {98},
	number = {7},
	pages = {900--904},
	year = {2014},
	doi = {10.1136/bjophthalmol-2013-304585},
	publisher = {BMJ Publishing Group Ltd},
	abstract = {Background/aims To describe the use of intraoperative online optical coherence tomography (iOCT) for improving deep anterior lamellar keratoplasty (DALK) surgery. Methods Retrospective case series of 6 eyes of 6 male patients with keratokonus, corneal dystrophy or herpetic stromal scars undergoing DALK were investigated using intraoperative optical coherence tomography and postsurgical image/video analysis. Main outcome measures were: visibility of surgical steps, especially, assessment of placement depth of injection needle, preparation of bare Descemet{\textquoteright}s membrane and drainage of interface fluid. Results iOCT enables real-time visualisation of all surgical steps of DALK procedure in all patients. Placement of air injection needle above Descemet{\textquoteright}s membrane was reliably monitored as was presence of bare Descemet{\textquoteright}s membrane and potential interface fluid. Conclusions iOCT assists with visualisation of injection needle placement and with assessment of bare Descemet{\textquoteright}s membrane as well as interface fluid during the DALK procedure. Overall iOCT may be a helpful device that supports surgeons in all steps of DALK procedure.},
	issn = {0007-1161},
	URL = {https://bjo.bmj.com/content/98/7/900},
	eprint = {https://bjo.bmj.com/content/98/7/900.full.pdf},
	journal = {British Journal of Ophthalmology}
}
S. Koinzer, S. Bajorat, C. Hesse, A. Caliebe, C. Roecken, and J. Roider,
Calibration of histological retina specimens after fixation in Margo's solution and paraffin embedding to in-vivo dimensions, using photography and optical coherence tomography, Graefes Arch Clin Exp Ophthalmol , vol. 252, no. 1, pp. 145--53, 2014.
DOI:10.1007/s00417-013-2457-6
Bibtex: BibTeX
@article{Koinzer2014,
title        = {Calibration of histological retina specimens after fixation in Margo's solution and paraffin embedding to in-vivo dimensions, using photography and optical coherence tomography},
author       = {Koinzer, S. and Bajorat, S. and Hesse, C. and Caliebe, A. and Bever, M. and Brinkmann, R. and Roecken, C. and Roider, J.},
year         = 2014,
journal      = {Graefes Arch Clin Exp Ophthalmol},
volume       = 252,
number       = 1,
pages        = {145--53},
doi          = {10.1007/s00417-013-2457-6},
issn         = {0721-832x},
note         = {1435-702x Koinzer, Stefan Bajorat, Sandra Hesse, Carola Caliebe, Amke Bever, Marco Brinkmann, Ralf Roecken, Christoph Roider, Johann Journal Article Research Support, Non-U.S. Gov't Germany Graefes Arch Clin Exp Ophthalmol. 2014 Jan;252(1):145-53. doi: 10.1007/s00417-013-2457-6. Epub 2013 Sep 14.},
abstract     = {BACKGROUND: The extent of retinal tissue deformation by histological processing needs to be separately measured for every workup protocol. This work presents a simple approach for its quantitative assessment, and shows lateral and axial scaling factors for a common protocol. We calibrated histological measurements by in-vivo photographic and optical coherence tomographic (OCT) measurements, using retinal photocoagulation lesions as calibration markers. METHODS: We evaluated four rabbit eyes that were examined histologically after fixation in Margo's solution(1% paraformaldehyde:1.25% glutaraldehyde), isopropanol dehydration, paraffin embedding and hematoxylin and eosin staining. Distances between 51 pairs of laser lesions were compared in photographs and on histological slides. Retinal thickness measurements were performed at 15 anatomically defined sites in these eyes, and related to anatomically matched OCT thickness measurements of six different rabbit eyes. RESULTS: We found that the ratio of histological over photographic lesion distances was 1.17 (95% CI 1.13-1.22), indicating 17% lateral retinal stretching or expansion by the processing. Thickness measurements in histology were 65.6% of the in-vivo thickness as measured in OCT, indicating 1/3 axial tissue compression or shrinkage. CONCLUSIONS: We provide an analysis of retinal tissue deformation after fixation in Margo's solution and paraffin embedding. In spite of protocol optimization for reduced tissue deformation, the workup caused 1/3 axial compression/shrinkage and 17% lateral elongation, which was unexpected. We show a simple way how to calibrate retina specimens by fundus photography and OCT, two methods that are readily available to most ophthalmologists. Our findings underline the necessity to calibrate specimens prior to morphometry.},
keywords     = {Animals Calibration *Histological Techniques Laser Coagulation *Paraffin Embedding Photography/*methods Rabbits *Retina *Tissue Fixation Tomography, Optical Coherence/*methods},
type         = {Journal Article}
}
A Vogel, S Freidank, and N. Linz,
Alternativen zur Femtosekundentechnologie: UV Subnanosekunden-pulse und Ringfoki für LASIK Flaperzeugung (at press), Ophthalomologe , vol. 111, no. 6, 2014.
Bibtex: BibTeX
@article{Vogel2014,
   author = {Vogel, A and Freidank, S and Linz, N },
   title = {Alternativen zur Femtosekundentechnologie: UV Subnanosekunden-pulse und Ringfoki für LASIK Flaperzeugung (at press)},
   journal = {Ophthalomologe },
   volume = {111},
   number = {6},
   year = {2014},
   type = {Journal Article}
}
Ingo Rohde, and Ralf Brinkmann,
Gain broadening and mode-locking in overcoupled second harmonic Q-switched microsecond pulses, Journal of Optics , vol. 16, no. 10, pp. 105209, 2014.
Datei: a=105209
Bibtex: BibTeX
@article{Rohde2014,
   author = {Rohde, Ingo and Brinkmann, Ralf},
   title = {Gain broadening and mode-locking in overcoupled second harmonic Q-switched microsecond pulses},
   journal = {Journal of Optics},
   volume = {16},
   number = {10},
   pages = {105209},
   abstract = {An intracavity frequency doubled, Q-switched Nd:YLF emitting at a wavelength of 527 nm was designed with the goal to temporally stretch the Q-switched pulses up to some microseconds at pulse energies of several millijoules. With different resonator configurations pulse durations between 12 μ s and 3 μ s with energies of 1 mJ–4.5 mJ have been achieved, which is demanded for an application in ophthalmology. For tighter intracavity foci and high pump power, however, strong power modulations by trains of picosecond pulses on the rear flank of the microsecond pulses were observed, indicating the occurrence of cascading nonlinearities and mode-locking. Simultaneously a significant increase of the fundamental spectrum up to 5 nm was found. A similar effect, which is referred to as gain broadening, has previously been observed by using ppKTP for intracavity second harmonic generation. This is, to the best of our knowledge, the first observation of this effect with unpoled second harmonic media.},
   ISSN = {2040-8986},
   url = {http://stacks.iop.org/2040-8986/16/i=10/a=105209},
   year = {2014},
   type = {Journal Article}
}
Ellen Guder, Eva Lankenau, F. Fleischhauer, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, H. W. Pau, and Tino Just,
Microanatomy of the tympanic membrane in chronic myringitis obtained with optical coherence tomography, European Archives of Oto-Rhino-Laryngology , pp. 1-7, 2014.
DOI:10.1007/s00405-014-3373-z
Datei: s00405-014-3373-z
Bibtex: BibTeX
@article{Guder2014,
   author = {Guder, Ellen and Lankenau, Eva and Fleischhauer, F. and Schulz-Hildebrandt, H. and Hüttmann, G. and Pau, H. W. and Just, Tino},
   title = {Microanatomy of the tympanic membrane in chronic myringitis obtained with optical coherence tomography},
   journal = {European Archives of Oto-Rhino-Laryngology},
   pages = {1-7},
   keywords = {Optical coherence tomography
Tympanic membrane
Chronic myringitis},
   ISSN = {0937-4477},
   DOI = {10.1007/s00405-014-3373-z},
   url = {http://dx.doi.org/10.1007/s00405-014-3373-z},
   year = {2014},
   type = {Journal Article}
}
Z. X. Li, E. Roussakis, P. G. L. Koolen, A. M. S. Ibrahim, K. Kim, L. F. Rose, J. Wu, A. J. Nichols, Y. Baek, G. Apiou-Sbirlea, R. Matyal, T. Huang, R. Chan, S. J. Lin, and C. L. Evans,
Non-invasive transdermal two-dimensional mapping of cutaneous oxygenation with a rapid-drying liquid bandage, Biomedical Optics Express , vol. 5, no. 11, pp. 3748-3764, 2014.
DOI:10.1364/Boe.5.003748
Bibtex: BibTeX
@article{Li2014,
   author = {Li, Z. X. and Roussakis, E. and Koolen, P. G. L. and Ibrahim, A. M. S. and Kim, K. and Rose, L. F. and Wu, J. and Nichols, A. J. and Baek, Y. and Birngruber, R. and Apiou-Sbirlea, G. and Matyal, R. and Huang, T. and Chan, R. and Lin, S. J. and Evans, C. L.},
   title = {Non-invasive transdermal two-dimensional mapping of cutaneous oxygenation with a rapid-drying liquid bandage},
   journal = {Biomedical Optics Express},
   volume = {5},
   number = {11},
   pages = {3748-3764},
   ISSN = {2156-7085},
   DOI = {10.1364/Boe.5.003748},
  
   year = {2014},
   type = {Journal Article}
}

2013

WooJhon Choi, Kathrin J. Mohler, Benjamin Potsaid, Chen D. Lu, Jonathan J. Liu, Vijaysekhar Jayaraman, Alex E. Cable, Jay S. Duker, Robert Huber, and James G. Fujimoto,
Choriocapillaris and choroidal microvasculature imaging with ultrahigh speed OCT angiography, PLOS ONE , vol. 8, no. 12, pp. 1-8, Dez. 2013. Public Library of Science.
DOI:10.1371/journal.pone.0081499
Bibtex: BibTeX
@article{10.1371/journal.pone.0081499,
    doi = {10.1371/journal.pone.0081499},
    author = {Choi, WooJhon AND Mohler, Kathrin J. AND Potsaid, Benjamin AND Lu, Chen D. AND Liu, Jonathan J. AND Jayaraman, Vijaysekhar AND Cable, Alex E. AND Duker, Jay S. AND Huber, Robert AND Fujimoto, James G.},
    journal = {PLOS ONE},
    publisher = {Public Library of Science},
    title = {Choriocapillaris and Choroidal Microvasculature Imaging with Ultrahigh Speed OCT Angiography},
    year = {2013},
    month = {12},
    volume = {8},
    url = {https://doi.org/10.1371/journal.pone.0081499},
    pages = {1-8},
    abstract = {We demonstrate in vivo choriocapillaris and choroidal microvasculature imaging in normal human subjects using optical coherence tomography (OCT). An ultrahigh speed swept source OCT prototype at 1060 nm wavelengths with a 400 kHz A-scan rate is developed for three-dimensional ultrahigh speed imaging of the posterior eye. OCT angiography is used to image three-dimensional vascular structure without the need for exogenous fluorophores by detecting erythrocyte motion contrast between OCT intensity cross-sectional images acquired rapidly and repeatedly from the same location on the retina. En face OCT angiograms of the choriocapillaris and choroidal vasculature are visualized by acquiring cross-sectional OCT angiograms volumetrically via raster scanning and segmenting the three-dimensional angiographic data at multiple depths below the retinal pigment epithelium (RPE). Fine microvasculature of the choriocapillaris, as well as tightly packed networks of feeding arterioles and draining venules, can be visualized at different en face depths. Panoramic ultra-wide field stitched OCT angiograms of the choriocapillaris spanning ∼32 mm on the retina show distinct vascular structures at different fundus locations. Isolated smaller fields at the central fovea and ∼6 mm nasal to the fovea at the depths of the choriocapillaris and Sattler's layer show vasculature structures consistent with established architectural morphology from histological and electron micrograph corrosion casting studies. Choriocapillaris imaging was performed in eight healthy volunteers with OCT angiograms successfully acquired from all subjects. These results demonstrate the feasibility of ultrahigh speed OCT for in vivo dye-free choriocapillaris and choroidal vasculature imaging, in addition to conventional structural imaging.},
    number = {12},

}
Philipp Steven, Carolin Le Blanc, Marc Krug, Eva Lankenau, Ludwig M Heindl, Uta Gehlsen, Gereon Hüttmann, and Claus Cursiefen,
Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography, JAMA Ophthalmology , vol. 131, no. 9, pp. 1135-42, 07 2013.
DOI:10.1001/jamaophthalmol.2013.4672
Bibtex: BibTeX
@article{10.1001/jamaophthalmol.2013.4672,
    author = {Steven, Philipp and Le Blanc, Carolin and Velten, Kai and Lankenau, Eva and Krug, Marc and Oelckers, Stefan and Heindl, Ludwig M. and Gehlsen, Uta and Hüttmann, Gereon and Cursiefen, Claus},
    title = "{Optimizing Descemet Membrane Endothelial Keratoplasty Using Intraoperative Optical Coherence Tomography}",
    journal = {JAMA Ophthalmology},
    volume = {131},
    number = {9},
    pages = {1135-1142},
    year = {2013},
    month = {09},
    abstract = "{Descemet membrane endothelial keratoplasty (DMEK) is a challenging procedure for the surgeon, particularly because of deficient visibility of the delicate tissue due to the natural en face view through the operating microscope. A cross-sectional view would greatly enhance intraoperative overview and enable the surgeon to better control the procedure.  To retrospectively analyze the use of intraoperative optical coherence tomography (iOCT) for improving the safety of DMEK.Intraoperative OCT during DMEK was performed in 26 eyes of 26 patients. We retrospectively analyzed imaging and video data. Department of Ophthalmology, University of Cologne.Seven men and 19 women aged 39 to 93 years with corneal endothelial dysfunction undergoing DMEK.Descemet membrane endothelial keratoplasty.Visibility of surgical steps, overall duration of DMEK, overall time for complete intraoperative air filling of the anterior chamber, and correlation between donor age and Descemet rolling behavior.Intraoperative OCT enables visualization of all steps of the DMEK procedure. Overall mean (SD) duration of the DMEK procedure was 25.7 (6.9) minutes when using iOCT. Overall mean (SD) complete intraoperative anterior chamber air-filling time was 236 (108) seconds in contrast to 60 to 90 minutes for standard air-filling time. Descemet membrane rolling behavior showed significant inverse correlation between donor age (range, 39-93 years) and the extent of rolling (R2 = 0.5 [P = .006]).Intraoperative OCT enhances the visibility of graft orientation and unfolding, thereby improving safety of the DMEK procedure. Overall, iOCT is a helpful device that may support surgeons in all steps of DMEK procedures.}",
    issn = {2168-6165},
    doi = {10.1001/jamaophthalmol.2013.4672},
    url = {https://doi.org/10.1001/jamaophthalmol.2013.4672},
    eprint = {https://jamanetwork.com/journals/jamaophthalmology/articlepdf/1708786/eoi130143.pdf},
}
Christoph M. Eigenwillig, Wolfgang Wieser, Sebastian Todor, Benjamin R. Biedermann, Thomas Klein, Christian Jirauschek, and Robert Huber,
Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers, Nature communications , vol. 4, pp. 1848-1855, 05 2013.
DOI:10.1038/ncomms2870
Bibtex: BibTeX
@Article{HU_2013_Eigenwillig_b,
  Title                    = {{Picosecond pulses from wavelength-swept continuous-wave Fourier domain mode-locked lasers}},
  Author                   = {Eigenwillig, Christoph M and Wieser, Wolfgang and Todor, Sebastian and Biedermann, Benjamin R and Klein, Thomas and Jirauschek, Christian and Huber, Robert},
  Journal                  = {Nature communications},
  Year                     = {2013},
  Month                    = jan,
  Pages                    = {1848--1855},
  Volume                   = {4},
  Doi                      = {10.1038/ncomms2870},
  ISSN                     = {2041-1723},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
  Url                      = {http://www.nature.com/ncomms/journal/v4/n5/abs/ncomms2870.html}
}
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