2024

S. Sonntag, B. Klein, R. Brinkmann, S. Grisanti, and Y. Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration, Translational Vision Science & Technology , vol. 13, pp. 24-24, 01 2024. https://doi.org/10.1167/tvst.13.1.24 .
DOI:10.1167/tvst.13.1.24
Weblink: https://doi.org/10.1167/tvst.13.1.24
Bibtex: BibTeX
@article{10.1167/tvst.13.1.24,
    author = {Sonntag, Svenja Rebecca and Klein, Britta and Brinkmann, Ralf and Grisanti, Salvatore and Miura, Yoko},
    title = "{Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration}",
    journal = {Translational Vision Science & Technology},
    volume = {13},
    number = {1},
    pages = {24-24},
    year = {2024},
    month = {01},
    abstract = "{   To investigate fluorescence lifetime of mouse models of age-related macular degeneration (AMD) by fluorescence lifetime imaging ophthalmoscopy (FLIO).    Two AMD mouse models, apolipoprotein E knockout (ApoE−/−) mice and NF-E2-related factor-2 knockout (Nrf2−/−) mice, and their wild-type mice underwent monthly ophthalmic examinations including FLIO from 3 months of age. After euthanasia at the age of 6 or 11 months, blood plasma was collected to determine total antioxidant capacity and eyes were enucleated for Oil red O (ORO) lipid staining of chorioretinal tissue.    In FLIO, the mean fluorescence lifetime (τm) of wild type shortened with age in both spectral channels. In short spectral channel, τm shortening was observed in both AMD models as well, but its rate was more pronounced in ApoE−/− mice and significantly different from the other strains as months of age progressed. In contrast, in long spectral channel, both model strains showed completely opposite trends, with τm becoming shorter in ApoE−/− and longer in Nrf2−/− mice than the others. Oil red O staining at Bruch's membrane was significantly stronger in ApoE−/− mice at 11 months than the other strains. Plasma total antioxidant capacity was highest in ApoE−/− mice at both 6 and 11 months.    The two AMD mouse models exhibited largely different fundus fluorescence lifetime, which might be related to the different systemic metabolic state. FLIO might be able to indicate different metabolic states of eyes at risk for AMD.    This animal study may provide new insights into the relationship between early AMD-associated metabolic changes and FLIO findings.  }",
    issn = {2164-2591},
    doi = {10.1167/tvst.13.1.24},
    url = {https://doi.org/10.1167/tvst.13.1.24},
    eprint = {https://arvojournals.org/arvo/content\_public/journal/tvst/938660/i2164-2591-13-1-24\_1706520239.75643.pdf},
}
P. Enzian, N. Kleineberg, E. Kirchert, C. Schell, and R. Rahmanzadeh,
Light-Induced Liposomal Drug Delivery with an Amphiphilic Porphyrin and Its Chlorin and Bacteriochlorin Analogues, Molecular Pharmaceutics , pp. null, 01 2024.
DOI:10.1021/acs.molpharmaceut.3c00749
File: acs.molpharmaceut.3c00749
Bibtex: BibTeX
@article{doi:10.1021/acs.molpharmaceut.3c00749,
author = {Enzian, Paula and Kleineberg, Nina and Kirchert, Elisabeth and Schell, Christian and Rahmanzadeh, Ramtin},
title = {Light-Induced Liposomal Drug Delivery with an Amphiphilic Porphyrin and Its Chlorin and Bacteriochlorin Analogues},
journal = {Molecular Pharmaceutics},
volume = {0},
number = {0},
pages = {null},
year = {0},
doi = {10.1021/acs.molpharmaceut.3c00749},
    note ={PMID: 38189667},

URL = { 
    
        https://doi.org/10.1021/acs.molpharmaceut.3c00749
    
    

},
eprint = { 
    
        https://doi.org/10.1021/acs.molpharmaceut.3c00749
    
    

}

}
A. Singh, M. Göb, M. Ahrens, T. Eixmann, B. Schulte, H. Schulz-Hildebrandt, G. Hüttmann, M. Ellrichmann, R. Huber, and M. Rahlves,
Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization, Opt. Express , vol. 32, no. 4, pp. 5809--5825, 2024. Optica Publishing Group.
DOI:10.1364/OE.514636
Bibtex: BibTeX
@article{Singh:24,
author = {Awanish Pratap Singh and Madita G\"{o}b and Martin Ahrens and Tim Eixmann and Berenice Schulte and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Mark Ellrichmann and Robert Huber and Maik Rahlves},
journal = {Opt. Express},
keywords = {Biomedical imaging; Endoscopic imaging; Imaging systems; Optical coherence tomography; Real time imaging; Vertical cavity surface emitting lasers},
number = {4},
pages = {5809--5825},
publisher = {Optica Publishing Group},
title = {Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization},
volume = {32},
month = {Feb},
year = {2024},
url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-32-4-5809},
doi = {10.1364/OE.514636},
abstract = {Circumferential scanning in endoscopic imaging is crucial across various disciplines, and optical coherence tomography (OCT) is often the preferred choice due to its high-speed, high-resolution, and micron-scale imaging capabilities. Moreover, real-time and high-speed 3D endoscopy is a pivotal technology for medical screening and precise surgical guidance, among other applications. However, challenges such as image jitter and non-uniform rotational distortion (NURD) are persistent obstacles that hinder real-time visualization during high-speed OCT procedures. To address this issue, we developed an innovative, low-cost endoscope that employs a brushless DC motor for scanning, and a sensorless technique for triggering and synchronizing OCT imaging with the scanning motor. This sensorless approach uses the motor\&\#x2019;s electrical feedback (back electromotive force, BEMF) as a virtual Hall sensor to initiate OCT image acquisition and synchronize it with a Fourier Domain Mode-Locked (FDML)-based Megahertz OCT system. Notably, the implementation of BEMF-triggered OCT has led to a substantial reduction in image jitter and NURD (\<4 mrad), thereby opening up a new window for real-time visualization capabilities. This approach suggests potential benefits across various applications, aiming to provide a more accurate, deployable, and cost-effective solution. Subsequent studies can explore the adaptability of this system to specific clinical scenarios and its performance under practical endoscopic conditions.},
}
N. Thiemann, S. Sonntag, M. Kreikenbohm, G. Böhmerle, J. Stagge, S. Grisanti, T. Martinetz, and Y. Miura,
Artificial Intelligence in Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Data Analysis—Toward Retinal Metabolic Diagnostics, Diagnostics , vol. 14, no. 4, 2024.
DOI:10.3390/diagnostics14040431
File: 431
Bibtex: BibTeX
@Article{diagnostics14040431,
AUTHOR = {Thiemann, Natalie and Sonntag, Svenja Rebecca and Kreikenbohm, Marie and Böhmerle, Giulia and Stagge, Jessica and Grisanti, Salvatore and Martinetz, Thomas and Miura, Yoko},
TITLE = {Artificial Intelligence in Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Data Analysis—Toward Retinal Metabolic Diagnostics},
JOURNAL = {Diagnostics},
VOLUME = {14},
YEAR = {2024},
NUMBER = {4},
ARTICLE-NUMBER = {431},
URL = {https://www.mdpi.com/2075-4418/14/4/431},
ISSN = {2075-4418},
ABSTRACT = {The purpose of this study was to investigate the possibility of implementing an artificial intelligence (AI) approach for the analysis of fluorescence lifetime imaging ophthalmoscopy (FLIO) data even with small data. FLIO data, including the fluorescence intensity and mean fluorescence lifetime (τm) of two spectral channels, as well as OCT-A data from 26 non-smokers and 28 smokers without systemic and ocular diseases were used. The analysis was performed with support vector machines (SVMs), a well-known AI method for small datasets, and compared with the results of convolutional neural networks (CNNs) and autoencoder networks. The SVM was the only tested AI method, which was able to distinguish τm between non-smokers and heavy smokers. The accuracy was about 80%. OCT-A data did not show significant differences. The feasibility and usefulness of the AI in analyzing FLIO and OCT-A data without any apparent retinal diseases were demonstrated. Although further studies with larger datasets are necessary to validate the results, the results greatly suggest that AI could be useful in analyzing FLIO-data even from healthy subjects without retinal disease and even with small datasets. AI-assisted FLIO is expected to greatly advance early retinal diagnosis.},
DOI = {10.3390/diagnostics14040431}
}
S. Burhan, N. Detrez, K. Rewerts, P. Strenge, S. Buschschlüter, J. Kren, C. Hagel, M. Bonsanto, R. Brinkmann, and R. Huber,
Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue, Biomed. Opt. Express , vol. 15, no. 2, pp. 1038--1058, 2024. Optica Publishing Group.
DOI:10.1364/BOE.510020
File: abstract.cfm
Bibtex: BibTeX
@article{Burhan:24,
author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Paul Strenge and Steffen Buschschl\"{u}ter and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {High speed imaging; Imaging systems; In vivo imaging; Magnetic resonance imaging; Phase noise; Phase shift},
number = {2},
pages = {1038--1058},
publisher = {Optica Publishing Group},
title = {Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue},
volume = {15},
month = {Feb},
year = {2024},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-15-2-1038},
doi = {10.1364/BOE.510020},
abstract = {During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2\&\#x2005;MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2\&\#x03C0; wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm\&\#x0027;s reliability. The tissue samples were subjected to a 200\&\#x2005;ms short air pulse. A correlation with histological findings confirmed the algorithm\&\#x0027;s dependability.},
}

2023

M. Klufts, A. Jiménez, S. Lotz, M. Bashir, T. Pfeiffer, A. Mlynek, W. Wieser, A. Chamorovskiy, A. Bradu, A. Podoleanu, and R. Huber,
828 kHz retinal imaging with an 840 nm Fourier domain mode locked laser, Biomed. Opt. Express , vol. 14, no. 12, pp. 6493-6508, Nov. 2023. Optica Publishing Group.
DOI:10.1364/BOE.504302
Bibtex: BibTeX
@article{Klufts:23,
author = {Marie Klufts and Alejandro Martinez Jimenez and Simon Lotz and Muhammad Asim Bashir and Tom Pfeiffer and Alexander Mlynek and Wolfgang Wieser and Alexander Chamorovskiy and Adrian Bradu and Adrian Podoleanu and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Analog to digital converters; Laser beams; Laser imaging; Laser modes; Point spread function; Vertical cavity surface emitting lasers},
number = {12},
pages = {6493--6508},
publisher = {Optica Publishing Group},
title = {828 kHz retinal imaging with an 840\&\#x2005;nm Fourier domain mode locked laser},
volume = {14},
month = {Dec},
year = {2023},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-14-12-6493},
abstract = {This paper presents a Fourier domain mode locked (FDML) laser centered around 840 nm. It features a bidirectional sweep repetition rate of 828 kHz and a spectral bandwidth of 40 nm. An axial resolution of ∼9.9 µm in water and a 1.4 cm sensitivity roll-off are achieved. Utilizing a complex master-slave (CMS) recalibration method and due to a sufficiently high sensitivity of 84.6 dB, retinal layers of the human eye in-vivo can be resolved during optical coherence tomography (OCT) examination. The developed FDML laser enables acquisition rates of 3D-volumes with a size of 200 × 100 × 256 voxels in under 100 milliseconds. Detailed information on the FDML implementation, its challenging design tasks, and OCT images obtained with the laser are presented in this paper.},
}
S. Burhan, N. Detrez, M. Göb, M. Bonsanto, R. Brinkmann, and R. Huber,
Advanced FFT-based contrast approach for MHz optical coherence elastography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 1263215.
DOI:10.1117/12.2670957
Bibtex: BibTeX
@inproceedings{10.1117/12.2670957,
author = {Sazgar Burhan and Nicolas Detrez and Madita G{\"o}b and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber},
title = {{Advanced FFT-based contrast approach for MHz optical coherence elastography}},
volume = {12632},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V},
editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1263215},
abstract = {Optical coherence elastography represents mechanical characteristics of biological tissue in so-called mechanical contrast maps. In addition to the standard intensity image, the contrast map illustrates numerous mechanical tissue features that would otherwise be undetectable. This is of great interest as abnormal physiological changes influence the mechanical behavior of the tissue. We demonstrate an advanced mechanical contrast approach based on the phase signal of our 3.2 MHz optical coherence tomography system. The robustness and performance of this contrast approach is evaluated and discussed based on preliminary results. },
keywords = {Optical Coherence Tomography, OCT, Megahertz OCT, Fourier Domain Mode Locking, Optical Coherence Elastography, OCE, Phase-sensitive OCT, Biomechanics},
year = {2023},
doi = {10.1117/12.2670957},
URL = {https://doi.org/10.1117/12.2670957}
}
W. Draxinger, D. Theisen-Kunde, L. Schuetz, N. Detrez, P. Strenge, M. Rixius, V. Danicke, W. Wieser, J. Kren, P. Kuppler, S. Spar-Hess, M. Bonsanto, R. Brinkmann, and R. Huber,
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 082023. pp. 126270W.
DOI:10.1117/12.2670953
Bibtex: BibTeX
@inproceedings{10.1117/12.2670953,
author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Schuetz and Nicolas Detrez and Paul Strenge and Maximilian Rixius and Veit Danicke and Wolfgang Wieser and Jessica Kren and Patrick Kuppler and Sonja Spar-Hess and Matteo Mario Bonsanto M.D. and Ralf Brinkmann and Robert Huber},
title = {{Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation}},
volume = {12627},
booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III},
editor = {Zhiwei Huang and Lothar D. Lilge},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126270W},
abstract = {Microscope integrated realtime 4D MHz-OCT operating at high scanning densities are capable of capturing additional visual contrast resolving depth and tissue. Even within a plain C-scan en-face projection structures are recognizable, that are not visible in a white light camera image. With advanced post processing methods, such as absorbtion coefficient mapping, and morphological classifiers more information is extraced. Presentation to the user in an intuitive way poses practical challenges that go beyond the implementation of a mere overlay display. We present our microscope integrated high speed 4D OCT imaging system, its clinical study use for in-vivo brain tissue imaging, and user feedback on the presentation methods we developed.},
keywords = {optical coherence tomography, neurosurgery, tissue contrast, image fusion, surgical guidance, theranostics},
year = {2023},
doi = {10.1117/12.2670953},
URL = {https://doi.org/10.1117/12.2670953}
}
P. Strenge, B. Lange, W. Draxinger, C. Hagel, C. Grill, V. Danicke, D. Theisen-Kunde, S. Spahr-Hess, M. Bonsanto, R. Huber, H. Handels, and R. Brinkmann,
Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321P.
DOI:10.1117/12.2670907
File: 12.2670907
Bibtex: BibTeX
@inproceedings{10.1117/12.2670907,
author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann},
title = {{Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}},
volume = {12632},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V},
editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126321P},
keywords = {Brain Tumor, OCT, Optical Coherence Tomography, Prior Network, Glioblastoma Multiforme, Neural Network, Classification},
year = {2023},
doi = {10.1117/12.2670907},
URL = {https://doi.org/10.1117/12.2670907}
}
M. Göb, S. Lotz, L. Ha-Wissel, S. Burhan, S. Böttger, F. Ernst, J. Hundt, and R. Huber,
Advances in large area robotically assisted OCT (LARA-OCT): towards drive-by continuous motion imaging, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321N.
DOI:10.1117/12.2670950
Bibtex: BibTeX
@inproceedings{10.1117/12.2670950,
author = {Madita G{\"o}b and Simon Lotz and Linh Ha-Wissel and Sazgar Burhan and Sven B{\"o}ttger and Floris Ernst and Jennifer Hundt and Robert Huber},
title = {{Advances in large area robotically assisted OCT (LARA-OCT): towards drive-by continuous motion imaging}},
volume = {12632},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V},
editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126321N},
abstract = {Optical coherence tomography is a powerful imaging technique to visualize and localize depth-dependent tissue structure to differentiate between healthy and pathological conditions. However, conventional OCT systems are only capable of detecting small areas. To overcome this limitation, we have developed a large area robotically assisted OCT (LARA-OCT) system for automatic acquisition of large OCT images. Using mosaic pattern acquisition and subsequent stitching, we previously demonstrated initial in vivo OCT skin images beyond 10 cm². To improve acquisition speed and reduce dead times, we here demonstrate and analyze LARA-OCT with a new drive-by continuous motion imaging protocol.},
keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, Robotically Assisted Imaging Systems, Three-dimensional image acquisition, Large Area Scanning, Skin Imaging, OCT, FDML},
year = {2023},
doi = {10.1117/12.2670950},
URL = {https://doi.org/10.1117/12.2670950}
}
M. Klufts, S. Lotz, M. Bashir, T. Pfeiffer, A. Mlynek, W. Wieser, A. Chamorovskiy, V. Shidlovski, A. Podoleanu, and R. Huber,
Dual Amplification 850 nm FDML Laser, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI:10.1109/CLEO/Europe-EQEC57999.2023.10232019
Bibtex: BibTeX
@INPROCEEDINGS{10232019,
  author={Klufts, M. and Lotz, S. and Bashir, M. A. and Pfeiffer, T. and Mlynek, A. and Wieser, W. and Chamorovskiy, A. and Shidlovski, V. and Podoleanu, A. and Huber, R.},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Dual Amplification 850 nm FDML Laser}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10232019}}
P. Lamminger, H. Hakert, S. Lotz, J. Kolb, T. Kutscher, S. Karpf, and R. Huber,
Four-Wave Mixing Fast Wavelength Sweeping FDML Laser with kW Peak Power at 900 nm and 1300 nm, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI:10.1109/CLEO/Europe-EQEC57999.2023.10232141
Bibtex: BibTeX
@INPROCEEDINGS{10232141,
  author={Lamminger, Philipp and Hakert, Hubertus and Lotz, Simon and Kolb, Jan Philip and Kutscher, Tonio and Karpf, Sebastian and Huber, Robert},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Four-Wave Mixing Fast Wavelength Sweeping FDML Laser with kW Peak Power at 900 nm and 1300 nm}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10232141}}
S. Lotz, M. Göb, W. Draxinger, A. Dick, and R. Huber,
13.4 MHz FDML Laser for Intra-Surgical Optical Coherence Tomography, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI:10.1109/CLEO/Europe-EQEC57999.2023.10231419
Bibtex: BibTeX
@INPROCEEDINGS{10231419,
  author={Lotz, Simon and Göb, Madita and Draxinger, Wolfgang and Dick, Anneli and Huber, Robert},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={13.4 MHz FDML Laser for Intra-Surgical Optical Coherence Tomography}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10231419}}
P. Enzian, and R. Rahmanzadeh,
Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer, Pharmaceutics , vol. 15, no. 8, 07 2023.
DOI:10.3390/pharmaceutics15082040
File: 2040
Bibtex: BibTeX
@Article{pharmaceutics15082040,
AUTHOR = {Enzian, Paula and Rahmanzadeh, Ramtin},
TITLE = {Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer},
JOURNAL = {Pharmaceutics},
VOLUME = {15},
YEAR = {2023},
NUMBER = {8},
ARTICLE-NUMBER = {2040},
URL = {https://www.mdpi.com/1999-4923/15/8/2040},
ISSN = {1999-4923},
ABSTRACT = {Head and neck squamous cell carcinoma (HNSCC) still represents the world’s sixth most common tumor entity, with increasing incidence. The reachability of light makes HNSCC suitable for light-based therapies such as Photochemical Internalization (PCI). The drug Bleomycin is cytotoxic and used as an anti-tumor medication. Since Bleomycin is endocytosed as a relatively large molecule, part of it is degraded in lysosomes before reaching its intracellular target. The goal of our study was to improve the intracellular availability of Bleomycin with PCI. We investigate the intracellular delivery of Bleomycin after PCI with the photosensitizer Fimaporfin. A systematic variation of Bleomycin and Fimaporfin concentrations and light irradiation led to the pronounced cell death of HNSCC cells. After optimization, the same level of tumor cell death of 75% was reached with a 20-fold lower Bleomycin concentration. This would allow treatment of HNSCC with high local tumor cell death and reduce the side effects of Bleomycin, e.g., lung fibrosis, at the same time. This demonstrates the increased efficacy of the anti-tumor medication Bleomycin in combination with PCI.},
DOI = {10.3390/pharmaceutics15082040}
}
S. Sonntag, M. Kreikenbohm, G. Böhmerle, J. Stagge, S. Grisanti, and Y. Miura,
Impact of cigarette smoking on fluorescence lifetime of ocular fundus, Scientific Reports , vol. 13, no. 1, pp. 11484, 07 2023.
DOI:10.1038/s41598-023-37484-4
File: s41598-023-37484-4
Bibtex: BibTeX
@article{RN5446,
   author = {Sonntag, Svenja Rebecca;Kreikenbohm, Marie;Böhmerle, Giulia;Stagge, Jessica;Grisanti, Salvatore and Miura, Yoko},
   title = {Impact of cigarette smoking on fluorescence lifetime of ocular fundus},
   journal = {Scientific Reports},
   volume = {13},
   number = {1},
   pages = {11484},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-023-37484-4},
   url = {https://doi.org/10.1038/s41598-023-37484-4},
   year = {2023},
   type = {Journal Article}
}
N. Heldt, C. Holzhausen, M. Ahrens, M. Pieper, P. König, and G. Hüttmann,
Improved image quality in dynamic OCT imaging of airway and lung tissue by reduced imaging time and machine learning based data evaluation, in Abstract Book 11th DZL Annual Meeting , 11th DZL Annual Meeting, Fürstenfeldbruck, 14–16 June 2023, Deutsches Zentrum für Lungenforschung e. V Geschäftsstelle Aulweg 130 35392 Gießen: DZL, 072023. pp. 357.
Weblink: https://dzl.de/wp-content/uploads/2023/06/Abstract-Book_2023-2.pdf
File: Dateilink
M. Bashir, S. Lotz, M. Klufts, C. Jirauschek, and R. Huber,
1190 nm FDML laser: Challenges and Strategies, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI:10.1109/CLEO/Europe-EQEC57999.2023.10232661
Bibtex: BibTeX
@INPROCEEDINGS{10232661,
  author={Bashir, M. A. and Lotz, S. and Kluftsa, M. and Jirauschek, C. and Huberab, R.},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={1190 nm FDML laser: Challenges and Strategies}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10232661}}
P. Lamminger, H. Hakert, S. Lotz, J. Kolb, T. Kutscher, S. Karpf, and R. Huber,
Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm, Opt. Lett. , vol. 48, no. 14, pp. 3713-3716, 07 2023. Optica Publishing Group.
DOI:10.1364/OL.488181
Bibtex: BibTeX
@article{Lamminger:23,
author = {Philipp Lamminger and Hubertus Hakert and Simon Lotz and Jan Philip Kolb and Tonio Kutscher and Sebastian Karpf and Robert Huber},
journal = {Opt. Lett.},
keywords = {Green fluorescent protein; Laser beam combining; Laser crystals; Laser imaging; Optical amplifiers; Photonic crystal lasers},
number = {14},
pages = {3713--3716},
publisher = {Optica Publishing Group},
title = {Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm},
volume = {48},
month = {Jul},
year = {2023},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-14-3713},
doi = {10.1364/OL.488181},
abstract = {Four-wave mixing (FWM) enables the generation and amplification of light in spectral regions where suitable fiber gain media are unavailable. The 1300 nm and 900 nm regions are of especially high interest for time-encoded (TICO) stimulated Raman scattering microscopy and spectro-temporal laser imaging by diffracted excitation (SLIDE) two-photon microscopy. We present a new, to the best of our knowledge, FWM setup where we shift the power of a home-built fully fiber-based master oscillator power amplifier (MOPA) at 1064 nm to the 1300-nm region of a rapidly wavelength-sweeping Fourier domain mode-locked (FDML) laser in a photonic crystal fiber (PCF) creating pulses in the 900-nm region. The resulting 900-nm light can be wavelength swept over 54 nm and has up to 2.5 kW (0.2 {\textmu}J) peak power and a narrow instantaneous spectral linewidth of 70 pm. The arbitrary pulse patterns of the MOPA and the fast wavelength tuning of the FDML laser (419 kHz) allow it to rapidly tune the FWM light enabling new and faster TICO-Raman microscopy, SLIDE imaging, and other applications.},
}
A. Leichtle, Z. Penxova, T. Kempin, D. Leffers, M. Ahrens, P. König, R. Brinkmann, G. Hüttmann, K. Bruchhage, and H. Schulz-Hildebrandt,
Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media, Photonics , vol. 10, no. 6, 06 2023.
DOI:10.3390/photonics10060685
File: 685
Bibtex: BibTeX
@Article{photonics10060685,
AUTHOR = {Leichtle, Anke and Penxova, Zuzana and Kempin, Thorge and Leffers, David and Ahrens, Martin and König, Peter and Brinkmann, Ralf and Hüttmann, Gereon and Bruchhage, Karl-Ludwig and Schulz-Hildebrandt, Hinnerk},
TITLE = {Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media},
JOURNAL = {Photonics},
VOLUME = {10},
YEAR = {2023},
NUMBER = {6},
ARTICLE-NUMBER = {685},
URL = {https://www.mdpi.com/2304-6732/10/6/685},
ISSN = {2304-6732},
ABSTRACT = {Hypothesis: Otitis media (OM) can be successfully visualized and diagnosed by dynamic microscopic optical coherence tomography (dmOCT). Background: OM is one of the most common infectious diseases and, according to the WHO, one of the leading health problems with high mortality in developing countries. Despite intensive research, the only definitive treatment of therapy-refractory OM for decades has been the surgical removal of inflamed tissue. Thereby, the intra-operative diagnosis is limited to the surgeon’s visual impression. Supportive imaging modalities have been little explored and have not found their way into clinical application. Finding imaging techniques capable of identifying inflamed tissue intraoperatively, therefore, is of significant clinical relevance. Methods: This work investigated a modified version of optical coherence tomography with a microscopic resolution (mOCT) regarding its ability to differentiate between healthy and inflamed tissue. Despite its high resolution, the differentiation of single cells with mOCT is often impossible. A new form of mOCT termed dynamic mOCT (dmOCT) achieves cellular contrast using micro-movements within cells based on their metabolism. It was used in this study to establish correlative measurements with histology. Results: Using dmOCT, images with microscopic resolution were acquired on ex vivo tissue samples of chronic otitis media and cholesteatoma. Imaging with dmOCT allowed the visualization of specific and characteristic cellular and subcellular structures in the cross-sectional images, which can be identified only to a limited extent in native mOCT. Conclusion: We demonstrated for the first time a new marker-free visualization in otitis media based on intracellular motion using dmOCT.},
DOI = {10.3390/photonics10060685}
}
M. Schmalz, X. Liang, I. Wieser, C. Gruschel, L. Muskalla, M. Stöckl, R. Nitschke, N. Linz, A. Leitenstorfer, A. Vogel, and E. Ferrando-May,
Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling, Proceedings of the National Academy of Sciences , vol. 120, no. 25, pp. e2220132120, 06 2023.
DOI:10.1073/pnas.2220132120
File: pnas.2220132120
Bibtex: BibTeX
@article{
doi:10.1073/pnas.2220132120,
author = {Michael Schmalz  and Xiao-Xuan Liang  and Ines Wieser  and Caroline Gruschel  and Lukas Muskalla  and Martin Thomas Stöckl  and Roland Nitschke  and Norbert Linz  and Alfred Leitenstorfer  and Alfred Vogel  and Elisa Ferrando-May },
title = {Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling},
journal = {Proceedings of the National Academy of Sciences},
volume = {120},
number = {25},
pages = {e2220132120},
year = {2023},
doi = {10.1073/pnas.2220132120},
URL = {https://www.pnas.org/doi/abs/10.1073/pnas.2220132120},
eprint = {https://www.pnas.org/doi/pdf/10.1073/pnas.2220132120},
abstract = {Understanding and predicting the outcome of the interaction of light with DNA has a significant impact on the study of DNA repair and radiotherapy. We report on a combination of femtosecond pulsed laser microirradiation at different wavelengths, quantitative imaging, and numerical modeling that yields a comprehensive picture of photon-mediated and free-electron-mediated DNA damage pathways in live cells. Laser irradiation was performed under highly standardized conditions at four wavelengths between 515 nm and 1,030 nm, enabling to study two-photon photochemical and free-electron-mediated DNA damage in situ. We quantitatively assessed cyclobutane pyrimidine dimer (CPD) and γH2AX-specific immunofluorescence signals to calibrate the damage threshold dose at these wavelengths and performed a comparative analysis of the recruitment of DNA repair factors xeroderma pigmentosum complementation group C (XPC) and Nijmegen breakage syndrome 1 (Nbs1). Our results show that two-photon-induced photochemical CPD generation dominates at 515 nm, while electron-mediated damage dominates at wavelengths ≥620 nm. The recruitment analysis revealed a cross talk between nucleotide excision and homologous recombination DNA repair pathways at 515 nm. Numerical simulations predicted electron densities and electron energy spectra, which govern the yield functions of a variety of direct electron-mediated DNA damage pathways and of indirect damage by •OH radicals resulting from laser and electron interactions with water. Combining these data with information on free electron–DNA interactions gained in artificial systems, we provide a conceptual framework for the interpretation of the wavelength dependence of laser-induced DNA damage that may guide the selection of irradiation parameters in studies and applications that require the selective induction of DNA lesions.}}
A. Altmann, M. Eden, G. Hüttmann, C. Schell, and R. Rahmanzadeh,
Porphyrin-based sensor films for monitoring food spoilage, Food Packaging and Shelf Life , vol. 38, pp. 101105, 06 2023.
DOI:https://doi.org/10.1016/j.fpsl.2023.101105
File: S2214289423000820
Bibtex: BibTeX
@article{ALTMANN2023101105,
title = {Porphyrin-based sensor films for monitoring food spoilage},
journal = {Food Packaging and Shelf Life},
volume = {38},
pages = {101105},
year = {2023},
issn = {2214-2894},
doi = {https://doi.org/10.1016/j.fpsl.2023.101105},
url = {https://www.sciencedirect.com/science/article/pii/S2214289423000820},
author = {Alexander Altmann and Michel Eden and Gereon Hüttmann and Christian Schell and Ramtin Rahmanzadeh},
keywords = {Biogenic amines, Sensors, Fish freshness, Food safety, Porphyrin, Smart packaging},
abstract = {To increase food safety and to minimize food waste, it is interesting for the food industry and consumers to be able to determine food spoilage continuously and non-destructively. When food of animal origin is degraded, amines are released as protein breakdown products, which could be used to monitor the freshness of meat and fish. In this work, we introduce a porphyrin-based sensor foil aimed at the detection of biogenic amines. The sensor-porphyrin is formulated on mesoporous silica. Reactivity towards moderate humidity was eliminated by dispersion of the functionalized silica in polyethylene (PE), followed by thermal extrusion resulting in PE foils. After exposure to amines, the sensor foil changes its color irreversibly from green to red. The color change is accompanied by a pronounced shift of the fluorescence spectrum, which was used as a sensitive method to detect the degradation of fish products in model experiments. Titanium dioxide particles in the foil increased the detected fluorescence emission. Experiments with fish filets showed the applicability of the sensor foils in a real-life application by indicating the degree of spoilage after several days, while the microbial growth was depicted by total viable count. We anticipate that our sensor can be an integral part of smart food packages, helping to track the freshness of food during transport or storage.}
}
S. Latus, S. Grube, T. Eixmann, M. Neidhardt, S. Gerlach, R. Mieling, G. Hüttmann, M. Lutz, and A. Schlaefer,
A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography, IEEE Transactions on Biomedical Engineering , pp. 1-9, 05 2023.
DOI:10.1109/TBME.2023.3275539
Bibtex: BibTeX
@ARTICLE{10122996,

  author={Latus, Sarah and Grube, Sarah and Eixmann, Tim and Neidhardt, Maximilian and Gerlach, Stefan and Mieling, Robin and Hüttmann, Gereon and Lutz, Matthias and Schlaefer, Alexander},

  journal={IEEE Transactions on Biomedical Engineering}, 

  title={A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography}, 

  year={2023},

  volume={},

  number={},

  pages={1-9},

  doi={10.1109/TBME.2023.3275539}}
P. Kuppler, P. Strenge, B. Lange, S. Spahr-Hess, W. Draxinger, C. Hagel, D. Theisen-Kunde, R. Brinkmann, R. Huber, V. Tronnier, and M. Bonsanto,
The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study, Frontiers in Oncology , vol. 13, 04 2023.
DOI:10.3389/fonc.2023.1151149
File: fonc.2023.1151149
Bibtex: BibTeX
Kuppler P, Strenge P, Lange B, Spahr-Hess S, Draxinger W, Hagel C, Theisen-Kunde D, Brinkmann R, Huber R, Tronnier V and Bonsanto MM (2023) The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study. Front. Oncol. 13:1151149. doi: 10.3389/fonc.2023.1151149
N. Linz, S. Freidank, X. Liang, and A. Vogel,
Laser Micro- and Nanostructuring for Refractive Eye Surgery, in Ultrafast Laser Nanostructuring: The Pursuit of Extreme Scales , Stoian, Razvanand and Bonse, Jörn, Eds. Cham: Springer International Publishing, 042023, pp. 1217--1245.
DOI:10.1007/978-3-031-14752-4_33
ISBN:978-3-031-14752-4
File: 978-3-031-14752-4_33
Bibtex: BibTeX
@Inbook{Linz2023,
author="Linz, Norbert
and Freidank, Sebastian
and Liang, Xiao-Xuan
and Vogel, Alfred",
editor="Stoian, Razvan
and Bonse, J{\"o}rn",
title="Laser Micro- and Nanostructuring for Refractive Eye Surgery",
bookTitle="Ultrafast Laser Nanostructuring: The Pursuit of Extreme Scales",
year="2023",
publisher="Springer International Publishing",
address="Cham",
pages="1217--1245",
abstract="Every year, more than a million refractive eye operations using femtosecond (fs) laser procedures are performed, and yet the cutting process in corneal tissue remains an area for development. In this chapter, we first review the state of the art of infrared (IR) fs laser dissection in laser in situ keratomileusis (LASIK) and small incision lenticule extraction (SMILE) and formulate the challenges for an improvement of precision and reduction of side effects. Since overcoming these challenges requires better knowledge of the cutting mechanisms, the plasma-mediated corneal dissection process is analyzed by high-speed photography of laser-induced bubble dynamics with up to 50 Mio frames/s, histological analysis of the cuts, and gas chromatography of the dissection products. Based on these results, we show that cutting efficiency and precision are improved through focus shaping by means of a helical phase plate, which converts the linear polarized Gaussian fs laser beam into a Laguerre-Gaussian vortex beam. The focus of the vortex beam has a ring shape with the same length in axial direction as the focus of a Gaussian beam but larger diameter. This greatly facilitates cleavage along the corneal lamellae, enabling cutting with low plasma energy density, higher precision, and fewer mechanical side effects. A shortening of the laser plasma length at constant focusing angle by use of UV-A laser pulses instead of IR pulses further improves precision. To compare the performance of UV and IR Gaussian and vortex beams, the incident and absorbed laser energy needed for easy removal of flaps created in porcine corneas are determined at various pulse durations and the smoothness of cuts is evaluated by scanning electron microscopy. Overall, vortex beams perform better than Gaussian beams for all wavelengths and can be easily implemented in clinical systems. Finally, we discuss a novel concept for refractive correction based on the introduction of refractive index changes in the corneal stroma by localized low-density plasma formation. Experimental findings that UV wavelengths work better for this purpose than IR wavelengths are explained through an analysis of the wavelength dependence of free electron density and energy spectrum that are obtained by numerical simulations.",
isbn="978-3-031-14752-4",
doi="10.1007/978-3-031-14752-4_33",
url="https://doi.org/10.1007/978-3-031-14752-4_33"
}
A. Hutfilz, D. Theisen-Kunde, M. Bonsanto, and R. Brinkmann,
Pulsed thulium laser blood vessel haemostasis as an alternative to bipolar forceps during neurosurgical tumour resection, Lasers in Medical Science , vol. 38, pp. 94, 03 2023. https://doi.org/10.1007/s10103-023-03747-9 .
DOI:10.1007/s10103-023-03747-9
Weblink: https://doi.org/10.1007/s10103-023-03747-9
Bibtex: BibTeX
@article{RN5430,
   author = {Hutfilz, Alessa;Theisen-Kunde, Dirk;Bonsanto, Matteo Mario and Brinkmann, Ralf},
   title = {Pulsed thulium laser blood vessel haemostasis as an alternative to bipolar forceps during neurosurgical tumour resection},
   journal = {Lasers in Medical Science},
   volume = {38},
   number = {1},
   pages = {94},
   ISSN = {1435-604X},
   DOI = {10.1007/s10103-023-03747-9},
   url = {https://doi.org/10.1007/s10103-023-03747-9},
   year = {2023},
   type = {Journal Article}
}
W. Draxinger, D. Theisen-Kunde, L. Schützeck, N. Detrez, P. Strenge, V. Danicke, J. Kren, P. Kuppler, S. Spahr-Hess, M. Bonsanto, R. Brinkmann, and R. Huber,
High speed 4D in-vivo OCT imaging of the human brain: creating high density datasets for machine learning toward identification of malign tissue in real time, in High-Speed Biomedical Imaging and Spectroscopy VIII , Kevin K. Tsia and Keisuke Goda, Eds. SPIE, 032023. pp. 123900D.
DOI:10.1117/12.2648505
Bibtex: BibTeX
@inproceedings{10.1117/12.2648505,
author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Sch{\"u}tzeck and Nicolas Detrez and Paul Strenge and Veit Danicke and Jessica Kren and Patrick Kuppler and Sonja Spahr-Hess and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber},
title = {{High speed 4D in-vivo OCT imaging of the human brain: creating high density datasets for machine learning toward identification of malign tissue in real time}},
volume = {12390},
booktitle = {High-Speed Biomedical Imaging and Spectroscopy VIII},
editor = {Kevin K. Tsia and Keisuke Goda},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {123900D},
abstract = {Neuro-surgery is challenged by the difficulties of determining brain tumor boundaries during excisions. Optical coherence tomography is investigated as an imaging modality for providing a viable contrast channel. Our MHz-OCT technology enables rapid volumetric imaging, suitable for surgical workflows. We present a surgical microscope integrated MHz-OCT imaging system, which is used for the collection of in-vivo images of human brains, with the purpose of being used in machine learning systems that shall be trained to identify and classify tumorous tissue.},
keywords = {optical coherence tomography, brain tumor, neurosurgery, machine learning, contrast augmentation, histology dataset, clinical study, in-vivo imaging},
year = {2023},
doi = {10.1117/12.2648505},
URL = {https://doi.org/10.1117/12.2648505}
}
T. Gottschall, T. Meyer-Zedler, M. Eibl, T. Pfeiffer, H. Hakert, M. Schmitt, R. Huber, A. Tünnermann, J. Limpert, and J. Popp,
Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy, The Journal of Physical Chemistry B , pp. null, 03 2023.
DOI:10.1021/acs.jpcb.2c09115
File: acs.jpcb.2c09115
Bibtex: BibTeX
@article{doi:10.1021/acs.jpcb.2c09115,
author = {Gottschall, Thomas and Meyer-Zedler, Tobias and Eibl, Matthias and Pfeiffer, Tom and Hakert, Hubertus and Schmitt, Michael and Huber, Robert and Tünnermann, Andreas and Limpert, Jens and Popp, Juergen},
title = {Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy},
journal = {The Journal of Physical Chemistry B},
volume = {0},
number = {0},
pages = {null},
year = {0},
doi = {10.1021/acs.jpcb.2c09115},
    note ={PMID: 36917762},
URL = {https://doi.org/10.1021/acs.jpcb.2c09115},
eprint = { https://doi.org/10.1021/acs.jpcb.2c09115}
}
M. Yamamoto, Y. Miura, K. Hirayama, A. Kyo, T. Kohno, D. Theisen-Kunde, R. Brinkmann, and S. Honda,
Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy, Life , vol. 13, no. 3, pp. 769, 03 2023.
DOI:10.3390/life13030769
File: 769
Bibtex: BibTeX
@article{RN5362,
   author = {Yamamoto, Manabu;Miura, Yoko;Hirayama, Kumiko;Kyo, Akika;Kohno, Takeya;Theisen-Kunde, Dirk;Brinkmann, Ralf and Honda, Shigeru},
   title = {Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy},
   journal = {Life},
   volume = {13},
   number = {3},
   pages = {769},
   ISSN = {2075-1729},
   DOI = {10.3390/life13030769},
   url = {https://www.mdpi.com/2075-1729/13/3/769},
   year = {2023},
   type = {Journal Article}
}
M. Klufts, S. Lotz, M. Bashir, T. Pfeiffer, A. Mlynek, W. Wieser, A. Chamorovskiy, V. Shidlovski, and R. Huber,
850 nm FDML: performance and challenges, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236705.
DOI:10.1117/12.2649646
Bibtex: BibTeX
@inproceedings{10.1117/12.2649646,
author = {M. Klufts and S. Lotz and M. A. Bashir and T. Pfeiffer and A. Mlynek and W. Wieser and A. Chamorovskiy and V. Shidlovski and R. Huber},
title = {{850 nm FDML: performance and challenges}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1236705},
abstract = {We demonstrate a Fourier domain mode locked (FDML) laser centered around 850 nm with a sweeping range of 50 nm, a fundamental repetition rate of 2×416 kHz and an output power of 2 mW. A new cavity design using three chirped Fiber Bragg gratings is required to overcome sweeping limitations caused by high dispersion. Other solutions to address challenges such as high loss and high polarization mode dispersion will be discussed along with performance. A main application of this laser will be retinal imaging, but it might also be applicable for TiCo-Raman and SLIDE microscopy. },
keywords = {Swept source, FDML, Laser, Ophthalmic imaging, OCT, 800 nm, retinal imaging, light sources},
year = {2023},
doi = {10.1117/12.2649646},
URL = {https://doi.org/10.1117/12.2649646}
}
A. Singh, M. Göb, M. Ahrens, T. Eixmann, H. Schulz-Hildebrandt, G. Hüttmann, R. Huber, and M. Rahlves,
Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236703.
DOI:10.1117/12.2652955
Bibtex: BibTeX
@inproceedings{10.1117/12.2652955,
author = {Awanish Pratap Singh and Madita G{\"o}b and Martin Ahrens and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H{\"u}ttmann and Robert Huber and Maik Rahlves},
title = {{Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1236703},
abstract = {High-speed endoscopic optical coherence tomography (OCT) imaging in the MHz range has shown great potential in various medical applications ranging from cancer screening to vascular disease monitoring. High-speed imaging always suffers from non-uniform rotational distortion (NURD) due to asynchronous motor rotation with the OCT system. Several research groups have previously attempted to solve this problem, using either an expensive motor with a sensor or numerical correction after data acquisition. However, both techniques pose challenges for practical use. Therefore, in this study, we use an inexpensive sensorless brushless DC motor with a Fourier domain mode-locked (FDML) laser-based MHz OCT system and try to resolve the problem of synchronization using three different modalities, (i) Slave-mode: The FDML frequency serves as a master frequency for the motor, which is phase-locked to the FDML frequency, (ii) Master-mode: The revolution trigger obtained from the motor’s back electromotive force (BEMF) signal serves as a trigger signal for the OCT imaging system, (iii) Both: Fully synchronized setup, where the motor rotation is synchronized with the laser and the imaging system is synchronized with the motor to achieve phase-stable OCT imaging. The first case slightly fluctuates in live preview and imaging due to the absence of a revolution trigger, while the second has varying motor speeds. Therefore, we use the third case to phase-lock the motor with FDML and get a distortion-free live preview and image acquisition. Finally, we demonstrate high-speed SS-OCT structural imaging (at 3.3 MHz A-scan rates) of a finger with a 16 mm diameter probe (at 40,000 rpm).},
keywords = {Optical Coherence Tomography, Endoscopy, FDML , Closed Loop Motor Control, NURD compensation, Brushless DC Motor, Back Electromotive Force},
year = {2023},
doi = {10.1117/12.2652955},
URL = {https://doi.org/10.1117/12.2652955}
}
S. Burhan, N. Detrez, K. Rewerts, M. Göb, C. Hagel, M. Bonsanto, D. Theisen-Kunde, R. Huber, and R. Brinkmann,
Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 123680F.
DOI:10.1117/12.2648301
Bibtex: BibTeX
@inproceedings{10.1117/12.2648301,
author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Madita G{\"o}b and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate}},
volume = {12368},
booktitle = {Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI},
editor = {Caroline Boudoux and James W. Tunnell},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {123680F},
abstract = {Optical coherence elastography (OCE) offers the possibility of obtaining the mechanical behavior of a tissue. When also  using a non-contact mechanical excitation, it mimics palpation without interobserver variability. One of the most frequently  used techniques is phase-sensitive OCE. Depending on the system, depth-resolved changes in the sub-µm to nm range can  be detected and visualized volumetrically. Such an approach is used in this work to investigate and detect transitions  between healthy and tumorous brain tissue as well as inhomogeneities in the tumor itself to assist the operating surgeon  during tumor resection in the future. We present time-resolved, phase-sensitive OCE measurements on various ex vivo brain tumor samples using an ultra-fast 3.2 MHz swept-source optical coherence tomography (SS-OCT) system with a frame rate of 2.45 kHz. 4 mm line scans are acquired which, in combination with the high imaging speed, allow monitoring and investigation of the sample's behavior in response to the mechanical load. Therefore, an air-jet system applies a 200 ms  short air pulse to the sample, whose non-contact property facilitates the possibility for future in vivo measurements. Since we can temporally resolve the response of the sample over the entire acquisition time, the mechanical properties are evaluated at different time points with depth resolution. This is done by unwrapping the phase data and performing subsequent assessment. Systematic ex vivo brain tumor measurements were conducted and visualized as distribution maps.  The study outcomes are supported by histological analyses and examined in detail.},
keywords = { Optical Coherence Tomography, Optical Coherence Elastography, Phase-sensitive OCT, Fourier Domain Mode Locking, Brain Tumor, Phase Unwrapping, Tissue Characterization, Biomechanics},
year = {2023},
doi = {10.1117/12.2648301},
URL = {https://doi.org/10.1117/12.2648301}
}
M. Bashir, S. Lotz, M. Klufts, I. Krestnikov, C. Jirauschek, and R. Huber,
1190 nm Fourier domain mode locked (FDML) laser for optical coherence tomography (OCT), in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236707.
DOI:10.1117/12.2652884
Bibtex: BibTeX
@inproceedings{10.1117/12.2652884,
author = {M. A. Bashir and S. Lotz and M. Klufts and I. Krestnikov and C. Jirauschek and R. Huber},
title = {{1190 nm Fourier domain mode locked (FDML) laser for optical coherence tomography (OCT)}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1236707},
abstract = {We demonstrate a Fourier domain mode locked (FDML) laser centered at 1190 nm with 2×410 kHz sweep repetition rate, a sweeping range of 100 nm and 2.5 mW output power. The laser is based on a quantum dot-semiconductor optical amplifier with small linewidth enhancement factor. The laser could be used as a probe laser in stimulated Raman scattering microscopy and it may be attractive for optical coherence tomography due to low water absorption and the spectral signature of lipids around 1200nm. Moreover, it is ideal to close the gap between FDML lasers at 1064 nm and 1300 nm. Combining these three lasers can enable ultrawideband sweeping to improve the axial OCT resolution down to 2 μm. },
keywords = {FDML, Swept source, laser, SS-OCT, OCT, Tunable lasers},
year = {2023},
doi = {10.1117/12.2652884},
URL = {https://doi.org/10.1117/12.2652884}
}
P. Lamminger, H. Hakert, S. Lotz, J. Kolb, T. Kutscher, S. Karpf, and R. Huber,
900 nm swept source FDML laser with kW peak power, in Fiber Lasers XX: Technology and Systems , V. R. Supradeepa, Eds. SPIE, 032023. pp. 124001I.
DOI:10.1117/12.2649663
Bibtex: BibTeX
@inproceedings{10.1117/12.2649663,
author = {Philipp Lamminger and Hubertus Hakert and Simon Lotz and Jan Philip Kolb and Tonio Kutscher and Sebastian Karpf and Robert Huber},
title = {{900 nm swept source FDML laser with kW peak power}},
volume = {12400},
booktitle = {Fiber Lasers XX: Technology and Systems},
editor = {V.  R. Supradeepa},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {124001I},
abstract = {A wavelength agile 900 nm 2.5 kW peak power fiber laser is created by four-wave mixing (FWM) in a photonic crystal fiber (PCF), while amplifying a 1300 nm Fourier-domain mode-locked (FDML) laser. The FWM process is pumped by a home-built 1064 nm master oscillator power amplifier (MOPA) laser and seeded by a home-built 1300 nm FDML laser, generating high power pulses at wavelengths, where amplification by active fiber media is difficult. The 900 nm pulses have a spectral linewidth of 70 pm, are tunable over 54 nm and have electronic pulse-to-pulse tuning capability. These pulses can be used for nonlinear imaging like two-photon or coherent anti-Stokes Raman microscopy (CARS) microscopy including spectro-temporal laser imaging by diffracted excitation (SLIDE) and time-encoded (Tico) stimulated Raman microscopy.},
keywords = {Fourier domain mode locking,  FDML, Raman, two photon microscopy, SLIDE, 900 nm, fiber laser, photonic crystal fiber, swept source},
year = {2023},
doi = {10.1117/12.2649663},
URL = {https://doi.org/10.1117/12.2649663}
}
M. Göb, S. Lotz, L. Ha-Wissel, S. Burhan, S. Böttger, F. Ernst, J. Hundt, and R. Huber,
Large area robotically assisted optical coherence tomography (LARA-OCT) for skin imaging with MHz-OCT surface tracking, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 123670C.
DOI:10.1117/12.2652616
Bibtex: BibTeX
@inproceedings{10.1117/12.2652616,
author = {Madita G{\"o}b and Simon Lotz and Linh Ha-Wissel and Sazgar Burhan and Sven B{\"o}ttger and Floris Ernst and Jennifer Hundt and Robert Huber},
title = {{Large area robotically assisted optical coherence tomography (LARA-OCT) for skin imaging with MHz-OCT surface tracking}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {123670C},
abstract = {Optical coherence tomography (OCT) is a powerful imaging technique to non-invasively differentiate between healthy skin and pathological conditions. Unfortunately, commercially available OCT-systems are typically slow and not capable of scanning large areas at reasonable speed. Since skin lesions may extend over several square centimeters, potential inflammatory infiltrates remain undetected. Here, we present large area robotically assisted OCT (LARA-OCT) for skin imaging. Therefor a collaborative robot is combined with an existing, home-built 3.3 MHz-OCT-system and for surface tracking an online probe-to-surface control is implemented which is solely based on the OCT surface signal. It features a combined surface-distance and surface-orientation closed-loop control algorithm, which enables automatic positioning and alignment of the probe across the target while imaging. This allows to acquire coherent OCT images of skin areas beyond 10 cm<sup>2</sup>. },
keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, Robotically Assisted Imaging Systems, Three-dimensional image acquisition, Large Area Scanning, Skin Imaging , OCT, FDML},
year = {2023},
doi = {10.1117/12.2652616},
URL = {https://doi.org/10.1117/12.2652616}
}
P. Strenge, B. Lange, W. Draxinger, C. Hagel, C. Grill, V. Danicke, D. Theisen-Kunde, S. Spahr-Hess, M. Bonsanto, R. Huber, H. Handels, and R. Brinkmann,
Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 1236805.
DOI:10.1117/12.2649963
Bibtex: BibTeX
@inproceedings{10.1117/12.2649963,
author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann},
title = {{Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography}},
volume = {12368},
booktitle = {Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI},
editor = {Caroline Boudoux and James W. Tunnell},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1236805},
abstract = {The ill-defined tumor borders of glioblastoma multiforme pose a major challenge for the surgeon during tumor resection,  since the goal of the tumor resection is the complete removal, while saving as much healthy brain tissue as possible. In  recent years, optical coherence tomography (OCT) was successfully used to classify white matter from tumor infiltrated  white matter by several research groups. Motivated by these results, a dataset was created, which consisted of sets of  corresponding ex vivo OCT images, which were acquired by two OCT-systems with different properties (e.g. wavelength  and resolution). Each image was annotated with semantic labels. The labels differentiate between white and gray matter  and three different stages of tumor infiltration. The data from both systems not only allowed a comparison of the ability of  a system to identify the different tissue types present during the tumor resection, but also enable a multimodal tissue  analysis evaluating corresponding OCT images of the two systems simultaneously. A convolutional neural network with  dirichlet prior was trained, which allowed to capture the uncertainty of a prediction. The approach increased the sensitivity  of identifying tumor infiltration from 58 % to 78 % for data with a low prediction uncertainty compared to a previous  monomodal approach. },
keywords = {optical coherence tomography, oct, brain, classification, tumor, dual wavelength, glioblastoma multiforme, tissue analysis},
year = {2023},
doi = {10.1117/12.2649963},
URL = {https://doi.org/10.1117/12.2649963}
}
M. Strauch, J. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf, and R. Huber,
Accelerating intraoperative tumor histology with sectioning-free multiphoton microscopy, European Journal of Surgical Oncology , vol. 49, no. 2, pp. e210, 02 2023.
DOI:https://doi.org/10.1016/j.ejso.2022.11.575
File: S0748798322013245
Bibtex: BibTeX
@article{STRAUCH2023e210,
title = {Accelerating intraoperative tumor histology with sectioning-free multiphoton microscopy},
journal = {European Journal of Surgical Oncology},
volume = {49},
number = {2},
pages = {e210},
year = {2023},
issn = {0748-7983},
doi = {https://doi.org/10.1016/j.ejso.2022.11.575},
url = {https://www.sciencedirect.com/science/article/pii/S0748798322013245},
author = {Matthias Strauch and Jan Philip Kolb and Christian Rose and Nadine Merg and Jennifer Hundt and Christiane Kümpers and Sven Perner and Sebastian Karpf and Robert Huber}
}
L. Puyo, C. Pfäffle, H. Spahr, J. Franke, D. Bublitz, D. Hillmann, and G. Hüttmann,
Diffuse-illumination holographic optical coherence tomography, Opt. Express , vol. 31, no. 20, pp. 33500--33517, 2023. Optica Publishing Group.
DOI:10.1364/OE.498654
File: abstract.cfm
Bibtex: BibTeX
@article{Puyo:23,
author = {L\'{e}o Puyo and Clara Pf\"{a}ffle and Hendrik Spahr and Jonas Franke and Daniel Bublitz and Dierck Hillmann and Gereon H\"{u}ttmann},
journal = {Opt. Express},
keywords = {Fourier optics; Full field optical coherence tomography; Image quality; Imaging techniques; Spatial frequency; Spatial light modulators},
number = {20},
pages = {33500--33517},
publisher = {Optica Publishing Group},
title = {Diffuse-illumination holographic optical coherence tomography},
volume = {31},
month = {Sep},
year = {2023},
url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-31-20-33500},
doi = {10.1364/OE.498654},
abstract = {Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing diffuse illumination of numerical aperture (NA) equal to the detection NA. While the reduction of speckle from singly scattered light is only modest, we discovered that speckle from multiply scattered light can be arbitrarily reduced, resulting in substantial improvements in image quality. This technique also offers the advantage of suppressing noises arising from spatial coherence, and can be implemented with a partially spatially incoherent light source for further mitigation of multiple scattering. Finally, we show that although holographic reconstruction capabilities are increasingly lost with decreasing spatial coherence, they can be retained over an axial range sufficient to standard OCT applications.},
}
L. Fu, X. Liang, S. Wang, S. Wang, P. Wang, Z. Zhang, J. Wang, A. Vogel, and C. Yao,
Laser induced spherical bubble dynamics in partially confined geometry with acoustic feedback from container walls, Ultrasonics Sonochemistry , vol. 101, pp. 106664, 2023.
DOI:https://doi.org/10.1016/j.ultsonch.2023.106664
File: S1350417723003760
Bibtex: BibTeX
@article{FU2023106664,
title = {Laser induced spherical bubble dynamics in partially confined geometry with acoustic feedback from container walls},
journal = {Ultrasonics Sonochemistry},
volume = {101},
pages = {106664},
year = {2023},
issn = {1350-4177},
doi = {https://doi.org/10.1016/j.ultsonch.2023.106664},
url = {https://www.sciencedirect.com/science/article/pii/S1350417723003760},
author = {Lei Fu and Xiao-Xuan Liang and Sijia Wang and Siqi Wang and Ping Wang and Zhenxi Zhang and Jing Wang and Alfred Vogel and Cuiping Yao},
keywords = {Laser-induced cavitation, Partial confinement, Acoustic feedback, Elastic wall, Vibrations, Extended Rayleigh-Plesset model},
abstract = {We investigated laser-induced cavitation dynamics in a small container with elastic thin walls and free or partially confined surface both experimentally and by numerical investigations. The cuvette was only 8–25 times larger than the bubble in its center. The liquid surface was either free, or two thirds were confined by a piston-shaped pressure transducer. Different degrees of confinement were realized by filling the liquid up to the transducer surface or to the top of the cuvette. For reference, some experiments were performed in free liquid. We recorded the bubble dynamics simultaneously by high-speed photography, acoustic measurements, and detection of probe beam scattering. Simultaneous single-shot recording of radius-time curves and oscillation times enabled to perform detailed investigations of the bubble dynamics as a function of bubble size, acoustic feedback from the elastic walls, and degree of surface confinement. The bubble dynamics was numerically simulated using a Rayleigh-Plesset model extended by terms describing the acoustically mediated feedback from the bubble’s environment. Bubble oscillations were approximately spherical as long as no secondary cavitation by tensile stress occurred. Bubble expansion was always similar to the dynamics in free liquid, and the environment influenced mainly the collapse phase and subsequent oscillations. For large bubbles, strong confinement led to a slight reduction of maximum bubble size and to a pronounced reduction of the oscillation time, and both effects increased with bubble size. The joint action of breakdown-induced shock wave and bubble expansion excites cuvette wall vibrations, which produce alternating pressure waves that are focused onto the bubble. This results in a prolongation of the collapse phase and an enlargement of the second oscillation, or in time-delayed re-oscillations. The details of the bubble dynamics depend in a complex manner on the degree of surface confinement and on bubble size. Numerical simulations of the first bubble oscillation agreed well with experimental data. They suggest that the alternating rarefaction/compression waves from breakdown-induced wall vibrations cause a prolongation of the first oscillation. By contrast, liquid mass movement in the cuvette corners result in wall vibrations causing late re-oscillations. The strong and rich interaction between the bubble and its surroundings may be relevant for a variety of applications such as intraluminal laser surgery and laser-induced cavitation in microfluidics.}
}
N. Detrez, S. Burhan, P. Strenge, J. Kren, C. Hagel, M. Bonsanto, D. Theisen-Kunde, R. Huber, and R. Brinkmann,
Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis, in Emerging Technologies for Cell and Tissue Characterization II , Seemantini K. Nadkarni and Giuliano Scarcelli, Eds. SPIE, 2023. pp. 126290M.
DOI:10.1117/12.2670944
File: 12.2670944
Bibtex: BibTeX
@inproceedings{10.1117/12.2670944,
author = {Nicolas Detrez and Sazgar Burhan and Paul Strenge and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis}},
volume = {12629},
booktitle = {Emerging Technologies for Cell and Tissue Characterization II},
editor = {Seemantini K. Nadkarni and Giuliano Scarcelli},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126290M},
keywords = {Optical Coherence Elastography, Air-Jet, Phase-sensitive OCT, Histology Structure Analysis, Color-Deconvolution, Structural Tensors, Brain tumor, Tissue Characterization},
year = {2023},
doi = {10.1117/12.2670944},
URL = {https://doi.org/10.1117/12.2670944}
}
N. Detrez, S. Burhan, K. Rewerts, J. Kren, C. Hagel, M. Bonsanto, D. Theisen-Kunde, R. Huber, and R. Brinkmann,
Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data, in Optical Elastography and Tissue Biomechanics X , Kirill V. Larin and Giuliano Scarcelli and Frédérique Vanholsbeeck, Eds. SPIE, 2023. pp. 1238105.
DOI:10.1117/12.2649835
File: 12.2649835
Bibtex: BibTeX
@inproceedings{10.1117/12.2649835,
author = {Nicolas Detrez and Sazgar Burhan and Katharina Rewerts and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data}},
volume = {12381},
booktitle = {Optical Elastography and Tissue Biomechanics X},
editor = {Kirill V. Larin and Giuliano Scarcelli and Fr{\'e}d{\'e}rique Vanholsbeeck},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1238105},
keywords = {Optical Coherence Elastography, Air-Jet, Air-Puff, biomechanics, viscoelasticity, rheology, brain tissue, brain tumor},
year = {2023},
doi = {10.1117/12.2649835},
URL = {https://doi.org/10.1117/12.2649835}
}
D. Theisen-Kunde, J. Kren, A. Hutfilz, M. Bonsanto, and R. Brinkmann,
Clinical evaluation of thulium laser / ultrasonic aspirator combination instrument during neurosurgical tumour resection, 2023.
Weblink: https://spie.org/european-conference-on-biomedical-optics/presentation/Clinical-evaluation-of-thulium-laser-ultrasonic-aspirator-combination-instrument-during/12627-34?SSO=1
Bibtex: BibTeX
@inproceedings{RN5454,
   author = {Theisen-Kunde, D;Kren, J;Hutfilz, A;Bonsanto, M and Brinkmann, R},
   title = {Clinical evaluation of thulium laser/ultrasonic aspirator combination instrument during neurosurgical tumour resection},
   booktitle = {ECBO},
   publisher = {SPIE},
   url = {https://spie.org/european-conference-on-biomedical-optics/presentation/Clinical-evaluation-of-thulium-laser-ultrasonic-aspirator-combination-instrument-during/12627-34},
   type = {Conference Proceedings}
}
D. Theisen-Kunde, F. Sommer, V. Danicke, L. Schützeck, S. Meyer, C. Kren, M. Rixius, and S. Karpf,
Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy, in Advances in Microscopic Imaging IV , Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park, Eds. SPIE, 2023. pp. 126300Q.
DOI:10.1117/12.2670881
File: 12.2670881
Bibtex: BibTeX
@inproceedings{10.1117/12.2670881,
author = {Dirk Theisen-Kunde and Florian Sommer and Veit Danicke and Lion Sch{\"u}tzeck and Stefan Meyer and Christopher Kren and Maximilian Rixius and Sebastian Karpf},
title = {{Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy}},
volume = {12630},
booktitle = {Advances in Microscopic Imaging IV},
editor = {Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126300Q},
keywords = {multiphoton microscopy, flow cytometry, Fourier Domain Mode Locked Laser, SLIDE, kHz- Imaging},
year = {2023},
doi = {10.1117/12.2670881},
URL = {https://doi.org/10.1117/12.2670881}
}
D. Theisen-Kunde, C. Burchard, V. Danicke, J. Fleger, C. Kren, S. Wittmeier, J. Roider, and R. Brinkmann,
Real-time temperature-control for cw retinal laser therapy in a clinical study, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 1262723.
DOI:10.1117/12.2670839
File: 12.2670839
Bibtex: BibTeX
@inproceedings{10.1117/12.2670839,
author = {Dirk Theisen-Kunde and Claus von der Burchard and Veit Danicke and Jan-Eric Fleger and Christopher Kren and Sebastian Wittmeier and Johann Roider and Ralf Brinkmann},
title = {{Real-time temperature-control for cw retinal laser therapy in a clinical study}},
volume = {12627},
booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III},
editor = {Zhiwei Huang and Lothar D. Lilge},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1262723},
keywords = {retinal laser, real time temperature control, clinical study, CSCR},
year = {2023},
doi = {10.1117/12.2670839},
URL = {https://doi.org/10.1117/12.2670839}
}
L. Buhl, M. Dolling, S. Kassumeh, S. Priglinger, R. Anderson, M. Bischoff, and R. Birngruber,
Corneal filler injection for enhancement after myopic small-incision lenticule extraction (SMILE), 2023.
DOI:10.1117/12.2649215
T. Kutscher, P. Lamminger, A. Gruber, C. Leonhardt, A. Hunold, R. Huber, and S. Karpf,
Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm, Opt. Lett. , vol. 48, no. 23, pp. 6096--6099, 2023. Optica Publishing Group.
DOI:10.1364/OL.500943
File: abstract.cfm
Bibtex: BibTeX
@article{Kutscher:23,
author = {Tonio F. Kutscher and Philipp Lamminger and Anton Gruber and Christina Leonhardt and Annika Hunold and Robert A. Huber and Sebastian Karpf},
journal = {Opt. Lett.},
keywords = {Erbium-doped fiber amplifiers; Laser imaging; Laser sources; Lidar; Multiphoton microscopy; Picosecond pulses},
number = {23},
pages = {6096--6099},
publisher = {Optica Publishing Group},
title = {Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm},
volume = {48},
month = {Dec},
year = {2023},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-23-6096},
doi = {10.1364/OL.500943},
abstract = {Swept-source lasers are versatile light sources for spectroscopy, imaging, and microscopy. Swept-source-powered multiphoton microscopy can achieve high-speed, inertia-free point scanning with MHz line-scan rates. The recently introduced spectro-temporal laser imaging by diffractive excitation (SLIDE) technique employs swept-source lasers to achieve kilohertz imaging rates by using a swept-source laser in combination with a diffraction grating for point scanning. Multiphoton microscopy at a longer wavelength, especially in the shortwave infrared (SWIR) region, can have advantages in deep tissue penetration or applications in light detection and ranging (LiDAR). Here we present a swept-source laser around 1550 nm providing high-speed wavelength agility and high peak power pulses for nonlinear excitation. The swept-source laser is a Fourier-domain mode-locked (FDML) laser operating at 326 kHz sweep rate. For high peak powers, the continuous wave (cw) output is pulse modulated to short picosecond pulses and amplified using erbium-doped fiber amplifiers (EDFAs) to peak powers of several kilowatts. This FDML-master oscillator power amplifier (FDML-MOPA) setup uses reliable, low-cost fiber components. As proof-of-principle measurement, we show third-harmonic generation (THG) using harmonic nanoparticles at the 10 MHz pulse excitation rate. This new, to the best of our knowledge, laser source provides unique performance parameters for applications in nonlinear microscopy, spectroscopy, and ranging.},
}
S. Meyer, T. Kutscher, P. Lamminger, F. Sommer, and S. Karpf,
Leveraging the periodic interference condition in electro-optic modulators for picosecond pulse generation, Opt. Continuum , vol. 2, no. 11, pp. 2298--2307, 2023. Optica Publishing Group.
DOI:10.1364/OPTCON.500969
File: abstract.cfm
Bibtex: BibTeX
@article{Meyer:23,
author = {Stefan Meyer and Tonio F. Kutscher and Philipp Lamminger and Florian Sommer and Sebastian Karpf},
journal = {Opt. Continuum},
keywords = {Femtosecond pulses; Fluorescence lifetime imaging; Phase modulation; Picosecond pulses; Single mode lasers; Ultrashort pulses},
number = {11},
pages = {2298--2307},
publisher = {Optica Publishing Group},
title = {Leveraging the periodic interference condition in electro-optic modulators for picosecond pulse generation},
volume = {2},
month = {Nov},
year = {2023},
url = {https://opg.optica.org/optcon/abstract.cfm?URI=optcon-2-11-2298},
doi = {10.1364/OPTCON.500969},
abstract = {Ultra-short optical pulses in the femtosecond and picosecond regime are typically generated using mode-locked lasers. However, in mode-locking, the pulse repetition rate is fundamentally linked to the cavity length of the laser, making it difficult to synchronize these laser pulses to other light sources. Here, we apply a pulse-on-demand approach to picosecond pulse generation with an electro-optic intensity modulator (EOM). The high, 40 GHz bandwidth of the EOM enables low picosecond pulses, however it shifts the problem of pulse generation to the electronic pulses, requiring high bandwidth electronics. In this study, we present an electro-optic operation, leveraging the periodic interference condition of intensity EOMs by operating it with rising edges at twice its V$\pi$ voltage. Utilizing this method, pulse durations as short as 10.9 ps were achieved by employing a 35 ps edge from an arbitrary waveform generator. The pulses were measured directly on a high-speed oscilloscope as well as indirectly through the spectral broadening of the generated optical pulses. We employ this approach to show arbitrary pulse length generation by applying step functions with only one V$\pi$ voltage, thus permitting direct pulse-on-demand generation of pulses with arbitrary pulse length, shape and repetition rate for applications in spectroscopy, sensing and nonlinear imaging.},
}
S. Burhan, N. Detrez, K. Rewerts, M. Göb, S. Buschschlüter, C. Hagel, M. Bonsanto, D. Theisen-Kunde, R. Huber, and R. Brinkmann,
Phase analysis strategies for MHz OCE in the large displacement regime, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 123670Q.
DOI:10.1117/12.2652847
Bibtex: BibTeX
@inproceedings{10.1117/12.2652847,
author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Madita G{\"o}b and Steffen Buschschl{\"u}ter and Christian Hagel and Matteo Mario Bonsanto M.D. and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Phase analysis strategies for MHz OCE in the large displacement regime}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {123670Q},
abstract = {In neurosurgical tumor operations on the central nervous system, intraoperative haptic information often assists for discrimination between healthy and diseased tissue. Thus, it can provide the neurosurgeon with additional intraoperative source of information during resection, next to the visual information by the light microscope, fluorescent dyes and neuronavigation. One approach to obtain elastic and viscoelastic tissue characteristics non-subjectively is phase-sensitive optical coherence elastography (OCE), which is based on the principle of optical coherence tomography (OCT). While phase-sensitive OCE offers significantly higher displacement sensitivity inside a sample than commonly used intensity-based correlation methods, it requires a reliable algorithm to recover the phase signal, which is mathematically restricted in the -&pi; to &pi; range. This problem of phase wrapping is especially critical for inter-frame phase analysis since the time intervals between two referenced voxels is long. Here, we demonstrate a one-dimensional unwrapping algorithm capable of removing up to 4&pi;-ambiguities between two frames in the complex phase data obtained from a 3.2 MHz-OCT system. The high sampling rate allows us to resolve large sample displacements induced by a 200 ms air pulse and acquires pixel-precise detail information. The deformation behavior of the tissue can be monitored over the entire acquisition time, offering various subsequent mechanical analysis procedures. The reliability of the algorithm and imaging concept was initially evaluated using different brain tumor mimicking phantoms. Additionally, results from human ex vivo brain tumor samples are presented and correlated with histological findings supporting the robustness of the algorithm.},
keywords = {Optical Coherence Tomography, Megahertz OCT, Fourier Domain Mode Locking, Optical Coherence Elastography, Phase-sensitive OCT, Phase Unwrapping, Brain tumor, Biomechanics},
year = {2023},
doi = {10.1117/12.2652847},
URL = {https://doi.org/10.1117/12.2652847}
}
C. Yao, X. Liang, S. Wang, J. Xin, L. Zhang, and Z. Zhang,
Optical Theranostics Based on Gold Nanoparticles, in Biomedical Photonic Technologies , John Wiley & Sons, Ltd, 2023, pp. 245-284.
DOI:https://doi.org/10.1002/9783527823550.ch8
ISBN:9783527823550
File: 9783527823550.ch8
Bibtex: BibTeX
@inbook{doi:https://doi.org/10.1002/9783527823550.ch8,
author = {Yao, Cuiping and Liang, Xiao-Xuan and Wang, Sijia and Xin, Jing and Zhang, Luwei and Zhang, Zhenxi},
publisher = {John Wiley & Sons, Ltd},
isbn = {9783527823550},
title = {Optical Theranostics Based on Gold Nanoparticles},
booktitle = {Biomedical Photonic Technologies},
chapter = {8},
pages = {245-284},
doi = {https://doi.org/10.1002/9783527823550.ch8},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527823550.ch8},
eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/9783527823550.ch8},
year = {2023},
keywords = {localized surface plasmon resonance, thermo-plasmonic effect, optical imaging, molecular diagnosis, tumor treatment, precise manipulation},
abstract = {Summary To obtain more detailed images of cellular processes or other nanoscale information in the fields of biology and medicine, or to improve phototherapy of cancer, various nanoparticles have emerged as optical probes, contrast agents, or optical absorbing agents. Among different nanoparticles, gold nanoparticle has obtained great attention and application in biomedical fields, such as optoporation, photo imaging, photodiagnosis, and phototherapy, due to their unique tunable optical, surface plasmon resonance, and photothermal features. In this chapter, the general physical mechanism of thermoplasmonic effects of gold nanoparticles was introduced, and the gold nanoparticles enhanced optical imaging, detection, and phototherapy of tumors was summarized.}
}
C. Grill, J. Kuhl, M. Schlenz, and R. Brinkmann,
Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 2023. pp. 126320J.
DOI:10.1117/12.2670874
File: 12.2670874
Bibtex: BibTeX
@inproceedings{10.1117/12.2670874,
author = {Christin Grill and Julie-Jacqueline Kuhl and Maximiliane Amelie Schlenz and Ralf Brinkmann},
title = {{Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography}},
volume = {12632},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V},
editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126320J},
keywords = {Optical Coherence Tomography, OCT, Monolithic dental crowns, CAD/CAM materials, Microcracks, Non-destructive method, Fatigue damage, Dental materials},
year = {2023},
doi = {10.1117/12.2670874},
URL = {https://doi.org/10.1117/12.2670874}
}
P. Enzian, B. Lange, Z. Penxova, A. Leichtle, Y. Miura, K. Bruchhage, and R. Brinkmann,
Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126271T.
DOI:10.1117/12.2670902
File: 12.2670902
Bibtex: BibTeX
@inproceedings{10.1117/12.2670902,
author = {Paula Enzian and Birgit Lange and Zuzana Penxov{\'a} and Anke Leichtle and Yoko Miura and Karl-Ludwig Bruchhage and Ralf Brinkmann},
title = {{Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples}},
volume = {12627},
booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III},
editor = {Zhiwei Huang and Lothar D. Lilge},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126271T},
keywords = {FLIM, autofluorescence, otitis media, cholesteatoma, middle ear, inflammation},
year = {2023},
doi = {10.1117/12.2670902},
URL = {https://doi.org/10.1117/12.2670902}
}
W. Draxinger, D. Theisen-Kunde, L. Schuetz, N. Detrez, P. Strenge, M. Rixius, V. Danicke, W. Wieser, J. Kren, P. Kuppler, S. Spar-Hess, M. M.D., R. Brinkmann, and R. Huber,
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270W.
DOI:10.1117/12.2670953
File: 12.2670953
Bibtex: BibTeX
@inproceedings{10.1117/12.2670953,
author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Schuetz and Nicolas Detrez and Paul Strenge and Maximilian Rixius and Veit Danicke and Wolfgang Wieser and Jessica Kren and Patrick Kuppler and Sonja Spar-Hess and Matteo Mario Bonsanto M.D. and Ralf Brinkmann and Robert Huber},
title = {{Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation}},
volume = {12627},
booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III},
editor = {Zhiwei Huang and Lothar D. Lilge},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126270W},
keywords = {optical coherence tomography, neurosurgery, tissue contrast, image fusion, surgical guidance, theranostics},
year = {2023},
doi = {10.1117/12.2670953},
URL = {https://doi.org/10.1117/12.2670953}
}
A. Jiménez, M. Spacek, M. Wacker, R. Huber, A. Bradu, and A. Podoleanu,
MHz time stretch swept source using a commercial erbium-doped fiber amplifier, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 1236706.
DOI:10.1117/12.2651127
File: 12.2651127
Bibtex: BibTeX
@inproceedings{10.1117/12.2651127,
author = {A. Mart{\'i}nez Jim{\'e}nez and M. Spacek and M. Wacker and R. Huber and A. Bradu and A. Podoleanu},
title = {{MHz time stretch swept source using a commercial erbium-doped fiber amplifier}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1236706},
keywords = {swept source, time-stretch, optical coherence tomography, mode-locking},
year = {2023},
doi = {10.1117/12.2651127},
URL = {https://doi.org/10.1117/12.2651127}
}
A. Altmann, M. Khodaygani, M. Leucker, C. Schell, and R. Rahmanzadeh,
Fluorescence based detection of gaseous food spoilage indicators, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270I.
DOI:10.1117/12.2671751
File: 12.2671751
Bibtex: BibTeX
@inproceedings{10.1117/12.2671751,
author = {Alexander Altmann and Mohammad Khodaygani and Martin Leucker and Christian Schell and Ramtin Rahmanzadeh},
title = {{Fluorescence based detection of gaseous food spoilage indicators}},
volume = {12627},
booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III},
editor = {Zhiwei Huang and Lothar D. Lilge},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126270I},
keywords = {fluorescence spectroscopy, gas sensing, optode technology, food safety, porphyrins, SVM classifier},
year = {2023},
doi = {10.1117/12.2671751},
URL = {https://doi.org/10.1117/12.2671751}
}

2022

Ö. Aşırım, R. Huber, and C. Jirauschek,
Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers, Applied Physics B , vol. 18(12), Nov. 2022.
DOI:10.1007/s00340-022-07933-5
Bibtex: BibTeX
@article{RN5426,
   author = {Aşırım, Özüm Emre;Huber, Robert and Jirauschek, Christian},
   title = {Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers},
   journal = {Applied Physics B},
   volume = {128},
   number = {12},
   pages = {218},
   ISSN = {1432-0649},
   DOI = {10.1007/s00340-022-07933-5},
   url = {https://doi.org/10.1007/s00340-022-07933-5},
   year = {2022},
   type = {Journal Article}
}
C. Jacobi, M. Göb, R. Huber, R. Ludwig, and J. Hundt,
620 Screening an inhibitor library for new drug candidates to promote wound healing, Journal of Investigative Dermatology , vol. 142, no. 12, Supplement, pp. S288, Nov. 2022.
DOI:https://doi.org/10.1016/j.jid.2022.09.637
File: S0022202X22025714
Bibtex: BibTeX
@article{JACOBI2022S288,
title = {620 Screening an inhibitor library for new drug candidates to promote wound healing},
journal = {Journal of Investigative Dermatology},
volume = {142},
number = {12, Supplement },
pages = {S288},
year = {2022},
note = {ESDR 2022 Meeting Abstract Supplement},
issn = {0022-202X},
doi = {https://doi.org/10.1016/j.jid.2022.09.637},
url = {https://www.sciencedirect.com/science/article/pii/S0022202X22025714},
author = {C. Jacobi and M. Göb and R. Huber and R.J. Ludwig and J.E. Hundt}
}
L. Ha-Wissel, H. Yasak, R. Huber, D. Zillikens, R. Ludwig, D. Thaci, and J. Hundt,
Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis, Frontiers in Medicine , vol. 9, 09 2022.
DOI:10.3389/fmed.2022.995883
File: fmed.2022.995883
Bibtex: BibTeX
@article{RN5359,
   author = {Ha-Wissel, L.;Yasak, H.;Huber, R.;Zillikens, D.;Ludwig, R. J.;Thaçi, D. and Hundt, J. E.},
   title = {Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis},
   journal = {Front Med (Lausanne)},
   volume = {9},
   pages = {995883},
   ISSN = {2296-858X (Print)
2296-858x},
   DOI = {10.3389/fmed.2022.995883},
   year = {2022},
   type = {Journal Article}
}
P. Strenge, B. Lange, W. Draxinger, C. Grill, V. Danicke, D. Theisen-Kunde, C. Hagel, S. Spahr-Hess, M. Bonsanto, H. Handels, R. Brinkmann, and R. Huber,
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
DOI:10.3389/fonc.2022.896060
Bibtex: BibTeX
@article{Strenge-2022,
   author = {Strenge, P.;Lange, B.;Grill,C.;Danicke,V.;Theisen-Kunde, D.;Hagel, C.;Spahr-Hess, S.;;Bonsanto, Matteo M.;Handels, H.; and Huber, R.;Brinkmann, R.},
   title = {Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology},
   journal = {Frontiers in Oncology},
Keywords = {AG-Huber_FDML, AG-Huber_OCT, brain, tumor, glioblastoma multiforme, OCT, neural network, attenuation (absorption)
coefficient, optical coherence tomography},
   DOI = {https://doi.org/10.3389/fonc.2022.896060},
   url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.896060/full},
   year = {2022},
   type = {Journal Article}
}
C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J. Kolb, W. Draxinger, S. Karpf, C. Jirauschek, and R. Huber,
Towards phase-stabilized Fourier domain mode-locked frequency combs, Communications Physics , vol. 5, no. 1, 08 2022. Springer Science and Business Media LLC.
DOI:10.1038/s42005-022-00960-w
Bibtex: BibTeX
@article{Grill2022,
  doi = {10.1038/s42005-022-00960-w},
  year = {2022},
  publisher = {Springer Science and Business Media {LLC}},
  volume = {{5}},
  number = {{1}},
  author = {C. Grill, T. Bl\"{o}mker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber},
  title = {Towards phase-stabilized Fourier domain mode-locked frequency combs},
  journal = {{Communications Physics}},
keywords={AG-Huber_FDML, FDML, Fourier domain mode locking, phase, frequency comb, coherence, beating}
}
P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, C. Hagel, S. Spahr-Hess, M. Bonsanto, R. Huber, H. Handels, and R. Brinkmann,
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
DOI:10.1088/1361-6560/ac6d9d
Bibtex: BibTeX
@article{Strenge2022,
   author = {Strenge, P;Lange, B;Grill, C;Draxinger, W;Danicke, V;Theisen-Kunde, D;Hagel, C;Spahr-Hess, S;Bonsanto, Matteo M.;Huber, R;Handels, H and Brinkmann, R},
   title = {Registration of histological brain images onto optical coherence tomography images based on shape information},
keywords = {brain, glioblastoma multiforme, shape, OCT, optical coherence tomography, AG-Huber_OCT,},
   journal = {Physics in Medicine & Biology},
   ISSN = {0031-9155},
   url = {http://iopscience.iop.org/article/10.1088/1361-6560/ac6d9d},
   year = {2022},
   type = {Journal Article}
}
C. Pfäffle, H. Spahr, K. Gercke, L. Puyo, S. Höhl, D. Melenberg, Y. Miura, G. Hüttmann, and D. Hillmann,
Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer, Frontiers in Medicine , vol. 9, 06 2022.
DOI:10.3389/fmed.2022.885187
File: fmed.2022.885187
Bibtex: BibTeX
@article{RN5328,
   author = {Pfäffle, C;Spahr, H;Gercke, K;Puyo, L;Höhl, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer},
   journal = {Frontiers in Medicine},
   volume = {9},
   ISSN = {2296-858X},
   DOI = {10.3389/fmed.2022.885187},
keywords = {optoretinography, optical coherence tomography, phase-sensitive OCT, functional imaging, inner
plexiform layer, retina},
   url = {https://www.frontiersin.org/articles/10.3389/fmed.2022.885187},
   year = {2022},
   type = {Journal Article}
}
M. Göb, S. Burhan, S. Lotz, and R. Huber,
Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032022. pp. 27 -- 31.
DOI:10.1117/12.2612171
Bibtex: BibTeX
@inproceedings{10.1117/12.2612171,
author = {Madita G{\"o}b and Sazgar Burhan and Simon Lotz and Robert Huber},
title = {{Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT}},
volume = {11948},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1194807},
abstract = {We demonstrate ultra-large field of view OCT scanning using standard optics, a X-Y-galvanometer scanner and a synchronously driven motorized XYZ-positioning stage. The integration of a movable stage into our self-built 3.3 MHz- OCT system allows acquiring coherent ultra-large area images, fully leveraging the high speed potential of our system. For fast OCT-angiography, one galvanometer axis scanner is driven in a repetitive sawtooth pattern, fully synchronized to the movement of the linear stage, to obtain multiple measurements at each position. This technique requires exact synchronization, precise repositioning, and uniform movements with low tolerances to ensure a minimum revisitation error. We analyze error and performance of our setup and demonstrate angiographic imaging.},
keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, FDML, Optical Coherence Angiography, OCTA, Medical optics and biotechnology, Medical imaging, Three-dimensional image acquisition, Scanners, Microscopy},
year = {2022},
doi = {10.1117/12.2612171},
URL = {https://doi.org/10.1117/12.2612171}
}
M. Klufts, S. Lotz, M. Bashir, S. Karpf, and R. Huber,
Ultra-high-accuracy chromatic dispersion measurement in optical fibers, in Optical Components and Materials XIX , Shibin Jiang and Michel J. F. Digonnet, Eds. SPIE, 032022. pp. 119970L.
DOI:10.1117/12.2608773
Bibtex: BibTeX
@inproceedings{10.1117/12.2608773,
author = {M. Klufts and S. Lotz and M. Bashir and S. Karpf and R. Huber},
title = {{Ultra-high-accuracy chromatic dispersion measurement in optical fibers}},
volume = {11997},
booktitle = {Optical Components and Materials XIX},
editor = {Shibin Jiang and Michel J. F. Digonnet},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {119970L},
abstract = {The chromatic dispersion in optical fibers is a key property for applications where a broadband light source is used and the timing of each individual wavelength is crucial. Counteracting the timing offset introduced by the fiber is a challenge in many applications especially in mode locked lasers. The dispersion parameters need to be measured with high precision. The length of the fiber, the temperature, and the used wavelength will highly impact the amount of dispersion and the accuracy of the measurement. We developed an ultra-high-accuracy dispersion measurement setup at 1080 &plusmn; 50 nm considering all the parameters that may influence the measurement. It is based on a home-built wavelength tunable laser where the output is modulated by an electro-optical modulator connected to a 24 GSamples/s arbitrary waveform generator to a complex pattern consisting of pulses and a 4 GHz sine wave. After passing through the fiber the signal is measured with an 80 GSamples/s real time oscilloscope. The fiber’s temperature is controlled to allow for reproducible measurements over several days and we achieve timing measurement accuracies down to ~200 fs. We also present the performance of the setup at ~850 nm. We will discuss and quantify all effects which can negatively impact the system accuracy and we will report on more cost-effective options using lower performance equipment.},
keywords = {Dispersion measurement, Chromatic dispersion, fiber dispersion measurement, optical component characterization, tunable laser, FDML},
year = {2022},
doi = {10.1117/12.2608773},
URL = {https://doi.org/10.1117/12.2608773}
}
A. Deen, H. van Beusekom, T. Pfeiffer, M. Stam, D. de Kleijn, J. Wentzel, R. Huber, A. van der Steen, G. van Soest, and T. Wang,
Spectroscopic thermo-elastic optical coherence tomography for tissue characterization, Biomedical Optics Express , vol. 13(3), pp. 1430-1446, 02 2022.
DOI:10.1364/BOE.447911
Bibtex: BibTeX
@article{Deen2022,
   author = {Deen, A D;Van Beusekom, H M. M.;Pfeiffer, T;Stam, M;Kleijn, D De;Wentzel, J;Huber, R;Van Der Steen, A F. W.;Soest, G Van and Wang, T},
   title = {Spectroscopic thermo-elastic optical coherence tomography for tissue characterization},
   journal = {BioOptExpr},
keywords = {AG-Huber, Endoscopic imaging, Image processing, Image quality, Imaging techniques, Optical imaging, Tissue characterization},
   volume = {13(3)},
   pages = {1430-1446},
   DOI = {10.1364/BOE.447911},
    year = {2022},
   type = {Journal Article}
}
M. Göb, T. Pfeiffer, W. Draxinger, S. Lotz, J. Kolb, and R. Huber,
Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence, Biomed. Opt. Express , vol. 13, no. 2, pp. 713--727, 02 2022. OSA.
DOI:10.1364/BOE.448353
Bibtex: BibTeX
@article{Gob:22,
author = {Madita G\"{o}b and Tom Pfeiffer and Wolfgang Draxinger and Simon Lotz and Jan Philip Kolb and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {High speed imaging; Image processing; Image quality; In vivo imaging; Range imaging; Vertical cavity surface emitting lasers},
number = {2},
pages = {713--727},
publisher = {Optica Publishing Group},
title = {Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence},
volume = {13},
month = {Feb},
year = {2022},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-13-2-713},
doi = {10.1364/BOE.448353},
abstract = {We present continuous three-dimensional spectral zooming in live 4D-OCT using a home-built FDML based OCT system with 3.28 MHz A-scan rate. Improved coherence characteristics of the FDML laser allow for imaging ranges up to 10 cm. For the axial spectral zoom feature, we switch between high resolution and long imaging range by adjusting the sweep range of our laser. We present a new imaging setup allowing for synchronized adjustments of the imaging range and lateral field of view during live OCT imaging. For this, a novel inline recalibration algorithm was implemented that enables numerical k-linearization of the raw OCT fringes for every frame instead of every volume. This is realized by acquiring recalibration data within the dead time of the raster scan at the turning points of the fast axis scanner. We demonstrate in vivo OCT images of fingers and hands at different resolution modes and show real three-dimensional zooming during live 4D-OCT. A three-dimensional spectral zooming feature for live 4D-OCT is expected to be a useful tool for a wide range of biomedical, scientific and research applications, especially in OCT guided surgery.},
}
K. Yashin, M. Bonsanto, K. Achkasova, A. Zolotova, A. Wael, E. Kiseleva, A. Moiseev, I. Medyanik, L. Kravets, R. Huber, R. Brinkmann, and N. Gladkova,
OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives, Diagnostics , vol. 12, no. 2, pp. 335, 01 2022.
DOI:10.3390/diagnostics12020335
File: 335
Bibtex: BibTeX
@article{Yashin-2022,
   author = {Yashin, K;Bonsanto, M M;Achkasova, K;Zolotova, A;Wael, Al-M;Kiseleva, E;Moiseev, A;Medyanik, I;Kravets, L;Huber, R;Brinkmann, R and Gladkova, N},
   title = {OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives},
   journal = {Diagnostics},
   volume = {12},
   number = {2},
   pages = {335},
   ISSN = {2075-4418},
keywords = {AG-Huber; optical coherence tomography; brain imaging; neurosurgical guidance; brain tumor; minimally invasive theranostics; intraoperative imaging},
   url = {https://www.mdpi.com/2075-4418/12/2/335},
   year = {2022},
   type = {Journal Article}
}
B. Lange, T. Ozimek, J. Wießmeyer, M. Kramer, A. Merseburger, and R. Brinkmann,
Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy, Biomedical Physics & Engineering Express , vol. 8, no. 5, pp. 055023, 2022.
DOI:10.1088/2057-1976/ac82c7
Bibtex: BibTeX
@article{Lange2022,
   author = {Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W.;Merseburger, A S. and Brinkmann, R},
   title = {Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy},
   journal = {Biomedical Physics & Engineering Express},
   volume = {8},
   number = {5},
abstract = {Objectives. In laser lithotripsy, a green aiming beam overlying the infrared (IR) treatment radiation gives rise to reflection and fluorescence signals that can be measured via the treatment fiber. While stone autofluorescence is used for target detection, the condition of the fiber can be assessed based on its Fresnel reflection. For good applicability, fluorescence detection of stones should work even when the stone and fiber are not in direct contact. Fiber breakage detection, on the other hand, can be falsified if surfaces located in front of the fiber reflect light from the aiming laser back into it. For both applications, therefore, a fundamental investigation of the dependence of the signal amplitude on the distance between fiber and surface is important. Methods. Calculations of the signal drop of fluorescence or diffuse and specular reflection with increasing fiber distance were performed using ray tracing based on a simple geometric model for different fiber core diameters. Reflection signals from a mirror, diffuse reflector, human calculi, and porcine renal tissue placed in water were measured at varying distances (0–5 mm). For human calculi, fluorescence signals were recorded simultaneously. Results. The calculations showed a linear signal decrease down to ∼60% of the maximum signal (fiber in contact). The distance z at which the signal drops to for example 50% depends linearly on the diameter of the fiber core. For fibers used in lithotripsy and positioned in water, z50% ranges from 0.55 mm (200 μm core diameter) to 2.73 mm, (1 mm core diameter). The calculations were in good agreement with the experimental results. Conclusions. The autofluorescence signals of stones can be measured in non-contact mode. Evaluating the Fresnel signal of the end face of the fiber to detect breakage is possible unless the fiber is situated less than some millimeters to reflecting surfaces.},
keywords = {urolithiasis, laser lithotripsy, fluorescence, reflectance},
   pages = {055023},
   ISSN = {2057-1976},
   DOI = {10.1088/2057-1976/ac82c7},
   
   year = {2022},
   type = {Journal Article}
}
Y. Miura, K. Inagaki, A. Hutfilz, E. Seifert, B. Schmarbeck, A. Murakami, K. Ohkoshi, and R. Brinkmann,
Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application, Life , vol. 12(9), pp. 1313, 2022.
DOI:https://doi.org/10.3390/life12091313
File: 1313
Bibtex: BibTeX
@article{Miura2022,
   author = {Miura, Y;Inagaki, K;Hutfilz, A;Seifert, E;Schmarbeck, B;Murakami, A;Ohkoshi, K and Brinkmann, R},
   title = {Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application},
   journal = {Life},
   volume = {12(9)},
  
   pages = {1313},
   ISSN = {2075-1729},
   url = {https://www.mdpi.com/2075-1729/12/9/1313},
   year = {2022},
   type = {Journal Article}
}
C. von der Burchard, H. Sudkamp, J. Tode, C. Ehlken, K. Purtskhvanidze, M. Moltmann, B. Heimes, P. Koch, M. Münst, M. vom Endt, T. Kepp, D. Theisen-Kunde, I. König, G. Hüttmann, and J. Roider,
Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study, BMJ Open , vol. 12, no. 6, pp. e055082, 2022.
DOI:10.1136/bmjopen-2021-055082
File: e055082.abstract
Bibtex: BibTeX
@article{von-der-Burchardt2022,
   author = {von der Burchard, C;Sudkamp, H;Tode, J;Ehlken, C;Purtskhvanidze, K;Moltmann, M;Heimes, B;Koch, P;Münst, M;vom Endt, M;Kepp, T;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J},
   title = {Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study},
   journal = {BMJ Open},
   volume = {12},
   number = {6},
   pages = {e055082},
   DOI = {10.1136/bmjopen-2021-055082},
   url = {http://bmjopen.bmj.com/content/12/6/e055082.abstract},
   year = {2022},
   type = {Journal Article}
}
x. Liang, N. Linz, S. Freidank, G. Paltauf, and A Vogel,
Comprehensive analysis of spherical bubble oscillations and shock wave emission in laser-induced cavitation, Journal of Fluid Mechanics , vol. 940, pp. A5, 2022.
DOI:10.1017/jfm.2022.202
Bibtex: BibTeX
@article{Liang2022,
   author = {Liang, X-X;Linz, N;Freidank, S;Paltauf, G and Vogel, A},
   title = {Comprehensive analysis of spherical bubble oscillations and shock wave emission in laser-induced cavitation},
keywords = {bubble dynamics, cavitation, shock waves},
   journal = {Journal of Fluid Mechanics},
   volume = {940},
   pages = {A5},
   ISSN = {0022-1120},
   DOI = {10.1017/jfm.2022.202},
  
   year = {2022},
   type = {Journal Article}
}
X. Liang, and A Vogel,
Probing neuronal functions with precise and targeted laser ablation in the living cortex: comment, Optica , vol. 9(8), pp. 868-871, 2022.
DOI:10.1364/OPTICA.454469
Bibtex: BibTeX
@article{Liang2022,
   author = {Liang, X-X and Vogel, A},
   title = {Probing neuronal functions with precise and targeted laser ablation in the living cortex: comment},
   journal = {Optica},
   volume = {9(8)},
   keywords = {Attenuation coefficient, Femtosecond lasers, Laser ablation, Laser irradiation, Numerical simulation, Thermal effects},
   pages = {868-871},
   DOI = {10.1364/OPTICA.454469},  
   year = {2022},
   type = {Journal Article}
}
M. Schaller, M. Wilson, V. Kleymann, M. Mordmüller, R. Brinkmann, M. Müller, and K. Worthmann,
Parameter estimation and model reduction for model predictive control in retinal laser treatment, Control Engineering Practice , vol. 128, pp. 105320, 2022.
DOI:https://doi.org/10.1016/j.conengprac.2022.105320
Bibtex: BibTeX
@article{Schaller2022,
   author = {Schaller, M;Wilson, M;Kleyman, V;Mordmüller, M;Brinkmann, R;Müller, M. A. and Worthmann, K},
   title = {Parameter estimation and model reduction for model predictive control in retinal laser treatment},
   journal = {Control Engineering Practice},
   volume = {128},
   pages = {105320},
   ISSN = {0967-0661},
   DOI = {https://doi.org/10.1016/j.conengprac.2022.105320},

   year = {2022},
   type = {Journal Article}
}
M. Schaller, V. Kleymann, M. Mordmüller, S. Christian, M. Wilson, R. Brinkmann, M. Müller, and K. Worthmann,
Model predictive control for retinal laser treatment at 1 kHz, at - Automatisierungstechnik , vol. 70(11), pp. 992-1002, 2022.
File: auto-2022-0030
Bibtex: BibTeX
@article{Schaller2022,
   author = {Schaller, M.;Kleyman, K.;Mordmüller, M.;Schmidt, C.;Wilson, M.;Brinkmann, R.;Müller, M.A. and Worthmann, K.},
   title = {Model predictive control for retinal laser treatment at 1 kHz},
   journal = {at - Automatisierungstechnik},
   volume = {70(11)},
   keywords = {model predictive control; real-time control;retinal photocoagulation},
   pages = {992-1002},
  
   url = {https://doi.org/10.1515/auto-2022-0030},
   year = {2022},
   type = {Journal Article}
}
S. Freidank, and N. Linz,
Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second, BioOptExpr , vol. 13 (5), pp. 3056-3079, 2022.
DOI:10.1364/BOE.455926
Bibtex: BibTeX
@article{Freidank2022,
   author = {Freidank, S;Vogel, A and Linz, N},
   title = {Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second},
   journal = {BioOptExpr},
   volume = {13 (5)},
   
   pages = {3056-3079},
   DOI = {10.1364/BOE.455926},

   year = {2022},
   type = {Journal Article}
}
T. Wang, T. Pfeiffer, A. Akyildiz, H. Beusekom, R. Huber, A. Steen, and G. Soest,
Intravascular optical coherence elastography, Biomed. Opt. Express , vol. 13, no. 10, pp. 5418--5433, 2022. Optica Publishing Group.
DOI:10.1364/BOE.470039
File: abstract.cfm
Bibtex: BibTeX
Optical coherence elastography (OCE), a functional extension of optical coherence tomography (OCT), visualizes tissue strain to deduce the tissue’s biomechanical properties. In this study, we demonstrate intravascular OCE using a 1.1 mm motorized catheter and a 1.6 MHz Fourier domain mode-locked OCT system. We induced an intraluminal pressure change by varying the infusion rate from the proximal end of the catheter. We analysed the pixel-matched phase change between two different frames to yield the radial strain. Imaging experiments were carried out in a phantom and in human coronary arteries in vitro. At an imaging speed of 3019 frames/s, we were able to capture the dynamic strain. Stiff inclusions in the phantom and calcification in atherosclerotic plaques are associated with low strain values and can be distinguished from the surrounding soft material, which exhibits elevated strain. For the first time, circumferential intravascular OCE images are provided side by side with conventional OCT images, simultaneously mapping both the tissue structure and stiffness.
Ö. Aşırım, R. Huber, and C. Jirauschek,
Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers, in 2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD) , 2022. pp. 67-68.
DOI:10.1109/NUSOD54938.2022.9894816
Bibtex: BibTeX
@INPROCEEDINGS{9894816,
  author={Aşırım, Ö. E. and Huber, R. and Jirauschek, C.},
  booktitle={2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD)}, 
  title={Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers}, 
  year={2022},
  volume={},
  number={},
  pages={67-68},
  doi={10.1109/NUSOD54938.2022.9894816}}
T. Kohlfaerber, M. Pieper, M. Münter, C. Holzhausen, M. Ahrens, C. Idel, L. Bruchhage, A. Leichtle, P. König, G. Hüttmann, and H. Schulz-Hildebrandt,
Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways, Biomedical Optics Express , vol. 13 (6), pp. 3211-3223, 2022.
DOI:10.1364/BOE.456104
Bibtex: BibTeX
@article{Kohlfarber2022,
   author = {Kohlfaerber, T;Pieper, M;Münter, M;Holzhausen, C;Ahrens, M;Idel, C;Bruchhage, K-L;Leichtle, A;König, P;Hüttmann, G and Schulz-Hildebrandt, H},
   title = {Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways},
   journal = {Biomedical Optics Express},
   volume = {13 (6)},
   pages = {3211-3223},
   DOI = {10.1364/BOE.456104},
  
   year = {2022},
   type = {Journal Article}
}
P Musial, T. Kohlfaerber, M. Ahrens, H. Schulz-Hildebrandt, P. Steven, and G. Hüttmann,
Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride, Translational Vision Science & Technology , vol. 11(5), pp. 28-28, 2022.
DOI:10.1167/tvst.11.5.28
File: tvst.11.5.28
Bibtex: BibTeX
@article{Musial-2022,
   author = {Musial, G;Kohlfaerber, T;Ahrens, M;Schulz-Hildebrandt, H;Steven, P and Hüttmann, G},
   title = {Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride},
   journal = {Translational Vision Science & Technology},
keywords = {toxicity; optical coherence tomography; benzalkonium chloride},
   volume = {11(5)},

   pages = {28-28},
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.11.5.28},
   url = {https://doi.org/10.1167/tvst.11.5.28},
   year = {2022},
   type = {Journal Article}
}
A. M. Goodwin, and F. Vanholsbeeck,
Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography, Osteoarthritis and Cartilage , 2022.
DOI:https://doi.org/10.1016/j.joca.2022.04.006
Bibtex: BibTeX
@article{GOODWIN2022,
title = {Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography},
journal = {Osteoarthritis and Cartilage},
year = {2022},
issn = {1063-4584},
doi = {https://doi.org/10.1016/j.joca.2022.04.006},
author = {M. Goodwin, M. Klufts, J. Workman, A. Thambyah and F. Vanholsbeeck},
keywords = {Optical coherence tomography, Polarisation-sensitive optical coherence tomography, Osteoarthritis},
abstract = {Summary
Objective
To explore the ability of polarisation-sensitive optical coherence tomography (PS-OCT) to rapidly identify subtle signs of tissue degeneration in the equine joint.
Method
Polarisation-sensitive optical coherence tomography (PS-OCT) images were systematically acquired in four locations along the medial and lateral condyles of the third metacarpal bone in five dissected equine specimens. Intensity and retardation PS-OCT images, and anomalies observed therein, were then compared and validated with high resolution images of the tissue sections obtained using Differential Interference contrast (DIC) optical light microscopy.
Results
The PS-OCT system was capable of imaging the entire equine osteochondral unit, and allowed delineation of the three structurally differentiated zones of the joint, that is, the articular cartilage matrix, zone of calcified cartilage and underlying subchondral bone. Importantly, PS-OCT imaging was able to detect underlying matrix and bone changes not visible without dissection and/or microscopy.
Conclusion
PS-OCT has substantial potential to detect, non-invasively, sub-surface microstructural changes that are known to be associated with the early stages of joint tissue degeneration.}
}

2021

P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber, and R. Brinkmann,
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dec.2021. pp. EW1C.7.
DOI:10.1117/12.2616044
Bibtex: BibTeX
@inproceedings{Strenge:21,
author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography},
pages = {EW1C.7},
publisher = {Optical Society of America},
title = {Comparison of two optical coherence tomography systems to identify human brain tumor},
year = {2021},
url = {https://doi.org/10.1117/12.2616044},
abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.},
}
M. Göb, S. Burhan, W. Draxinger, J. Kolb, and R. Huber,
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dec.2021. pp. EW3C.4.
DOI:10.1117/12.2616054
Bibtex: BibTeX
@inproceedings{Gob:21,
author = {Madita G\"{o}b and Sazgar Burhan and Wolfgang Draxinger and Jan Philip Kolb and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT;Fourier domain mode locking; Image processing; Image quality; Optical coherence tomography; Temporal resolution; Three dimensional imaging},
pages = {EW3C.4},
publisher = {Optical Society of America},
title = {Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm$^2$/sec},
year = {2021},
url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-EW3C.4},
abstract = {We demonstrate a 3.3 MHz A-scan rate OCT for rapid scanning of large areas of human skin. The mosaicking performance and different OCT imaging modalities including intervolume speckle contrast are evaluated.},
}
N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlüter, M. Bonsanto, D. Theisen-Kunde, and R. Brinkmann,
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dec.2021. pp. EW4A.10.
Weblink: https://opg.optica.org/abstract.cfm?uri=ECBO-2021-EW4A.10
Bibtex: BibTeX
@inproceedings{Detrez:21,
author = {N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlueter, M.M. Bonsanto, D. Theisen-Kunde and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT},
pages = {EW4A.10},
publisher = {Optical Society of America},
title = {Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography},
year = {2021},
url = {https://doi.org/10.1117/12.2615022},
abstract = {A precision air puff excitation system for MHz Optical Coherence Elastography in neurosurgery was developed. It enables non-contact soft-tissue excitation down to {\textmu}N, with direct, noncontact force determination via gas flow measurement.},
}
K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlüter, M. Bonsanto, R. Huber, and R. Brinkmann,
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dec.2021. pp. ETh3A.3.
Weblink: https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETh3A.3
Bibtex: BibTeX
@inproceedings{Rewerts2021ECBO,
author = {K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlueter, M.M. Bonsanto, R. Huber and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT},
pages = {ETh3A.3},
publisher = {Optical Society of America},
title = {Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation},
year = {2021},
url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-ETh3A.3},
abstract = {Tumor discrimination from healthy tissue is often performed by haptically probing tissue elasticity. We demonstrate non-contact elastography using air-puff excitation and tissue indentation measurement by phase-sensitive OCT with a 3.2 MHz FDML-laser.},
}
C. Pfäffle, H. Spahr, K. Gercke, S. Burhan, D. Melenberg, Y. Miura, G. Hüttmann, and D. Hillmann,
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, 082021.
DOI:10.1117/12.2577605
Bibtex: BibTeX
@inproceedings{RN5321,
   author = {Pfäffle, C;Spahr, H;Gercke, K;Burhan, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer},
   booktitle = {SPIE BiOS},
   publisher = {SPIE},
   volume = {11623},
   url = {https://doi.org/10.1117/12.2577605},
   type = {Conference Proceedings}
}
P. Gruening, F. Nette, N. Heldt, A. Souza, and E. Barth,
Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning, in Proceedings of the Fourth Conference on Medical Imaging with Deep Learning , Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris, Eds. PMLR, 072021. pp. 219--227.
Weblink: https://proceedings.mlr.press/v143/gruening21a.html
File: gruening21a.html
Bibtex: BibTeX
@InProceedings{pmlr-v143-gruening21a,
  title = 	 {Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning},
  author =       {Gruening, Philipp and Nette, Falk and Heldt, Noah and de Souza, Ana Cristina Guerra and Barth, Erhardt},
  booktitle = 	 {Proceedings of the Fourth Conference on Medical Imaging with Deep Learning},
  pages = 	 {219--227},
  year = 	 {2021},
  editor = 	 {Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris},
  volume = 	 {143},
  series = 	 {Proceedings of Machine Learning Research},
  month = 	 {07--09 Jul},
  publisher =    {PMLR},
  pdf = 	 {https://proceedings.mlr.press/v143/gruening21a/gruening21a.pdf},
  url = 	 {https://proceedings.mlr.press/v143/gruening21a.html},
  abstract = 	 {With in-line holography, it is possible to record biological cells over time in a three-dimensional hydrogel without the need for staining, providing the capability of observing cell behavior in a minimally invasive manner. However, this setup currently requires computationally intensive image-reconstruction algorithms to determine the required cell statistics. In this work, we directly extract cell positions from the holographic data by using deep neural networks and thus avoid several reconstruction steps. We show that our method is capable of substantially decreasing the time needed to extract information from the raw data without loss in quality.}
}
H. Hakert, M. Eibl, M. Tillich, R. Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, L. Bruchhage, S. Karpf, and R. Huber,
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
DOI:10.1364/OL.424726
Bibtex: BibTeX
@article{Hakert2021,
   author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber},
   title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1},
   journal = {Optics Letters},
   volume = {46(14)},
   number = {14},
   pages = {3456-3459},
keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering},
   DOI = {https://doi.org/10.1364/OL.424726},
   year = {2021},
   type = {Journal Article}
}
T. Peñate Medina, J. Kolb, G. Hüttmann, R. Huber, O. Peñate Medina, N. Larsen, A. Ferrari, M. Rafecas, M. Ellrichmann, M. Pravdivtseva, M. Anikeeva, J. Humbert, M. Both, J. Hundt, and J. Hövener,
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
DOI:10.3389/fimmu.2021.692222
Bibtex: BibTeX
@article{PenateMedina2021,
   author = {Peñate Medina, T;Kolb, J P;Hüttmann, G;Huber, R;Peñate Medina, O;Ha, L;Ulloa, P;Larsen, N;Ferrari, A;Rafecas, M;Ellrichmann, M;Pravdivtseva, M S.;Anikeeva, M;Humbert, J;Both, M;Hundt, J E. and Hövener, J-B},
   title = {Imaging Inflammation - From Whole Body Imaging to Cellular Resolution},
   journal = {Frontiers in immunology},
keywords = {AG-Huber, MRI, PET, SPECT, optical imaging, Optical coherence tomography (OCT), precision medicine, Two-Photon microscopy (TPM), hyperpolarization},
   volume = {12},
   pages = {692222-692222},
   ISSN = {1664-3224},
   DOI = {10.3389/fimmu.2021.692222},
   url = {https://pubmed.ncbi.nlm.nih.gov/34248987
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264453/},
   year = {2021},
   type = {Journal Article}
}
C. Grill, S. Lotz, T. Blömker, M. Schmidt, W. Draxinger, J. Kolb, C. Jirauschek, and R. Huber,
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
DOI:10.1109/CLEO/Europe-EQEC52157.2021.9542126
Bibtex: BibTeX
@INPROCEEDINGS{9542126,
  author={Grill, Christin and Lotz, Simon and Blömker, Torben and Schmidt, Mark and Draxinger, Wolfgang and Kolb, Jan Philip and Jirauschek, Christian and Huber, Robert},
  booktitle={2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Superposition of two independent FDML lasers}, 
  year={2021},
  volume={},
  number={},
  pages={1-1},
  abstract={Fourier domain mode locking (FDML) is a laser operating regime, which was developed in 2005 [1] . The output of this laser is a train of optical wavelength sweeps, equivalent to extremely chirped pulses with an optical bandwidth of up to 25 THz and frequency tuning rates of >10 19 Hz/s. This laser type was developed for optical coherence tomography [2] , but found recently more and more applications like LiDAR [3] , Raman microscopy [4] or two-photon microscopy [5] . The laser’s coherence properties are relevant for a better understanding of the FDML laser itself and its applications. Because of the wide sweep range and high tuning rate, the laser linewidth cannot be measured with an RF spectrometer. Superposition with a narrowband continuous wave laser only yields phase information for small fractions of the sweep [6] . However, beat signal measurements between two independent FDML lasers with equal sweep range and direction can give information about the complete sweep.},
  keywords={},
  doi={10.1109/CLEO/Europe-EQEC52157.2021.9542126},
  ISSN={},
  month={June}
}
T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill, and R. Huber,
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
DOI:10.1117/12.2583501
Bibtex: BibTeX
@inproceedings{Pfeiffer2021,
author = {T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill and R. Huber},
title = {{High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers}},
volume = {11630},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
abstract = {We demonstrate that the coherence roll-off and dynamic range of OCT systems using Fourier-domain mode-locked (FDML) lasers can be significantly improved by a fiber Fabry-Perot tunable filter (FFP-TF) with a finesse of more than 3000, a more than fivefold improvement over previous designs. In contrast to previous work, standard resampling using a pre-acquired signal (as in SD-OCT) with no k-clocking is sufficient for 20 nm and 100 nm sweep range, significantly reducing the system complexity. 3D-OCT imaging at 20 cm imaging range is demonstrated.},
keywords = {AG-Huber_FDML, AG-Huber_OCT, optical coherence tomography, FDML laser, swept source laser, high finesse, Fabry-Perot, MHz-OCT, OCT, tunable laser},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2583501}
}
T. Gottschall, T. Meyer-Zedler, M. Schmitt, R. Huber, J. Popp, A. Tünnermann, and J. Limpert,
Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging, JRS , 06 2021.
DOI:10.1002/jrs.6171
Bibtex: BibTeX
@article{Gottschall2021,
   author = {T. Gottschall, T. Meyer-Zedler, M. Schmitt, R. Huber, J. Popp, A. Tünnermann and J. Limpert},
   title = {Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging},
   journal = {JRS},
  keywords = { AG-Huber_NL, coherent anti-Stokes Raman scattering microscopy, four-wave mixing, nonlinear
microscopy, ultrafast laser},
   ISSN = {0377-0486},   
   url = {https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jrs.6171},
   year = {2021},
   type = {Journal Article}
}
M. Strauch, J. Kolb, W. Draxinger, A. Popp, M. Wacker, N. Merg, J. Hundt, S. Karpf, and R. Huber,
Sectioning-free virtual H&E histology with fiber-based two-photon microscopy, in SPIE BiOS , SPIE, 032021.
DOI:10.1117/12.2578334
Bibtex: BibTeX
@inproceedings{RN5318,
   author = {Strauch, M;Kolb, J P;Draxinger, W;Popp, A-K;Wacker, M;Merg, N;Hundt, J;Karpf, S and Huber, R},
   title = {Sectioning-free virtual H&E histology with fiber-based two-photon microscopy},
   booktitle = {SPIE BiOS},
   publisher = {SPIE},
   volume = {11648},
Year = {2021},
   DOI = {https://doi.org/10.1117/12.2578334},
   url = {https://doi.org/10.1117/12.2578334},
   type = {Conference Proceedings}
}
S. Lotz, C. Grill, M. Göb, W. Draxinger, J. Kolb, and R. Huber,
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
DOI:10.1364/BOE.422898
Bibtex: BibTeX
@article{Lotz2021,
   author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber},
   title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision},
   journal = {Biomedical Optics Express},
   volume = {12(5)},
   keywords={AG-Huber_FDML},
   pages = {2604-2616},
   url = {https://doi.org/10.1364/BOE.422898},
   year = {2021},
   type = {Journal Article}
}
C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J. Kolb, W. Draxinger, S. Karpf, C. Jirauschek, and R. Huber,
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
DOI:10.1117/12.2578293
Bibtex: BibTeX
@inproceedings{Grill2021,
author = {C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber},
title = {{A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements}},
volume = {11665},
booktitle = {Fiber Lasers XVIII: Technology and Systems},
editor = {Michalis N. Zervas},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {242 -- 247},
keywords = {AG-Huber_FDML, Fourier domain mode locking, FDML laser, laser beating , tunable laser, optical coherence tomography, OCT},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2578293}
}
P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber, and R. Brinkmann,
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
DOI:10.1117/12.2578391
Bibtex: BibTeX
@inproceedings{Strenge2021,
author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann},
title = {{Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples}},
volume = {11630},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {66 -- 73},
abstract = {Optical coherence tomography (OCT) has the potential to become an additional imaging modality for surgical guidance in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. Interpretation of the images, however, is still a big challenge. A method to create a labeled OCT dataset based on ex vivo brain samples is introduced. The tissue samples were embedded in an agarose mold giving them a distinctive shape before images were acquired with two OCT systems (spectral domain (SD) and swept source (SS) OCT) and histological sections were created and segmented by a neuropathologist. Based on the given shape, the corresponding OCT images for each histological image can be determined. The transfer of the labels from the histological images onto the OCT images was done with a non-affine image registration approach based on the tissue shape. It was demonstrated that finding OCT images of a tissue sample corresponding to segmented histological images without any color or laser marking is possible. It was also shown that the set labels can be transferred onto OCT images. The accuracy of method is 26 ± 11 pixel, which translates to 192 ± 75 μm for the SS-OCT and 94 ± 43 μm for the SD-OCT. The dataset consists of several hundred labeled OCT images, which can be used to train a classification algorithm.},
keywords = {AG-Huber_OCT, optical coherence tomography, OCT, image registration, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery},
year = {2021},
URL = {https://doi.org/10.1117/12.2578391}
}
P. Lamminger, M. Loop, J. Klee, D. Weng, J. Kolb, M. Strauch, S. Karpf, and R. Huber,
Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups, in Multimodal Biomedical Imaging XVI , SPIE, 032021.
DOI:10.1117/12.2578679
Bibtex: BibTeX
@Conference{Lamminger2021,
  author    = {P. Lamminger, M. Loop, J. Klee, D. Weng, J.P. Kolb, M. Strauch, S. Karpf and R. Huber},
  booktitle = {Multimodal Biomedical Imaging XVI},
  title     = {Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups},
  year      = {2021},
  publisher = {SPIE},
  doi       = {10.1117/12.2578679},
  keywords  = {AG-Huber_NL, AG-Huber_OCT},
}
P. Strenge, B. Lange, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber, and R. Brinkmann,
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
DOI:10.1117/12.2578409
Bibtex: BibTeX
@inproceedings{Strenge2021A,
author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann},
title = {{Characterization of brain tumor tissue with 1310 nm optical coherence tomography}},
volume = {11630},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {74 -- 80},
abstract = {The separation of tumorous brain tissue and healthy brain tissue is still a big challenge in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. On the basis of a recently created labelled OCT dataset of ex vivo glioblastoma multiforme tumor samples the detection of brain tumor tissue and the identification of zones with varying degrees of infiltration of tumor cells was investigated. The identification was based on the optical properties, which were extracted by an exponential fit function. The results showed that a separation of tumorous tissue and healthy white matter based on these optical properties is possible. A support vector machine was trained on the optical properties to separate tumor from healthy white matter tissue, which achieved a sensitivity of 91% and a specificity of 76% on an independent training dataset.},
keywords = {AG-Huber_OCT, optical coherence tomography, OCT, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2578409}
}
M. Schmidt, C. Grill, S. Lotz, T. Pfeiffer, R. Huber, and C. Jirauschek,
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
DOI:10.1007/s00340-021-07600-1
Bibtex: BibTeX
@Article{Schmidt2021,
  author   = {M. Schmidt, C. Grill, S. Lotz, T. Pfeiffer, R. Hubert and C. Jirauschek},
  journal  = {Applied Physics B},
  title    = {Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime},
  year     = {2021},
  issn     = {1432-0649},
  number   = {5},
  pages    = {60},
  volume   = {127},
keywords={AG-Huber_FDML},
  abstract = {We report on the formation of various intensity pattern types in detuned Fourier domain mode-locked (FDML) lasers and identify the corresponding operating conditions. Such patterns are a result of the complex laser dynamics and serve as an ideal tool for the study of the underlying physical processes as well as for model verification. By numerical simulation we deduce that the formation of patterns is related to the spectral position of the instantaneous laser lineshape with respect to the transmission window of the swept bandpass filter. The spectral properties of the lineshape are determined by a long-term accumulation of phase-offsets, resulting in rapid high-amplitude intensity fluctuations in the time domain due to the narrow intra-cavity bandpass filter and the fast response time of the semiconductor optical amplifier gain medium. Furthermore, we present the distribution of the duration of dips in the intensity trace by running the laser in the regime in which dominantly dips form, and give insight into their evolution over a large number of roundtrips.},
  doi      = {10.1007/s00340-021-07600-1},
  refid    = {Schmidt2021},
}
F. Hilge, M. Evers, M. Casper, J. Glahn, W. M.D., G. M.D., H. Schulz-Hildebrandt, G. Hüttmann, and D. M.D.,
Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography, in Photonics in Dermatology and Plastic Surgery 2021 , Bernard Choi and Haishan Zeng, Eds. SPIE, 2021.
DOI:10.1117/12.2577822
File: 12.2577822
Bibtex: BibTeX
@inproceedings{10.1117/12.2577822,

title = {Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography},

author = {Felix Hilge and Michael Evers and Malte Casper and Joshua Zev Glahn and Weeranut Phothong M.D. and Garuna Kositratna M.D. and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Dieter Manstein M.D.},

editor = {Bernard Choi and Haishan Zeng},

url = {https://doi.org/10.1117/12.2577822},

doi = {10.1117/12.2577822},

year  = {2021},

date = {2021-01-01},

booktitle = {Photonics in Dermatology and Plastic Surgery 2021},

volume = {11618},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
M. Strauch, J. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf, and R. Huber,
Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy, in 33rd Congress of the ESP , 2021.
DOI:10.1007/s00428-021-03157-8
Bibtex: BibTeX
@Conference{Strauch2021,
  author    = {M. Strauch, J.P. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf and R. Huber},
  booktitle = {33rd Congress of the ESP},
  title     = {Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy},
  year      = {2021},
  keywords  = {AG-Huber_NL},
}
M. Mordmüller, V. Kleymann, M. Schaller, M. Wilson, K. Worthmann, M. Müller, and R. Brinkmann,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
File: 12.2615851
Bibtex: BibTeX
@inproceedings{Mordmüller2021,
   author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R},
   title = { Towards Model-based Control Techniques for Retinal Laser
Treatment Using Only One Laser},
   booktitle = {ECBO},
url = {https://doi.org/10.1117/12.2615851},
year = {2021},
   type = {Conference Proceedings}
}
A. Deen,
Spectroscopic analysis through thermoelastic optical coherence microscopy, in European Conferences on Biomedical Optics , SPIE, 2021.
File: 12.2616068
Bibtex: BibTeX
@inproceedings{Deen2021,
   author = {Doug Deen, A;Pfeiffer, T;van Beusekom, H;Essers, J;van der Steen, A F.;Huber, Rt;van Soest, G and Wang, T},
   title = {Spectroscopic analysis through thermoelastic optical coherence microscopy},
   booktitle = {European Conferences on Biomedical Optics},
   publisher = {SPIE},
year = {2021},
   volume = {11924},
   url = {https://doi.org/10.1117/12.2616068},
   type = {Conference Proceedings}
}
M. Büttner, B. Luger, W. Moulig, B. Junker, C. Framme, C. Jacobson, K. Knoll, A. Pielen, SRT Study Group-Theisen-Kunde, Brinkmann, Miura,Birngruber, R. Brinkmann, D. Theisen-Kunde, and Y. Miura,
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
DOI:10.1007/s00417-020-04999-9
Bibtex: BibTeX
@article{Büttner2021,
   author = {Büttner, M.;Luger, B.;Abou Moulig, W.;Junker, B.;Framme, C.;Jacobsen, C.;Knoll, K. and Pielen, A.; SRT Study Group(Brinkmann, R.; Miura, Y.)},
   title = {Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   volume = {259},
   number = {6},
   pages = {1401-1410},
   ISSN = {0721-832X (Print)
0721-832x},
   DOI = {10.1007/s00417-020-04999-9},
abstract = { PURPOSE: Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% within 6 months. In this study, the efficacy of selective retina therapy (SRT) was examined in patients with therapy refractory persistent acute CSC defined by symptoms for at least 6 months and persistent subretinal fluid (SRF) despite eplerenone therapy. MATERIAL AND METHODS: This is a prospective, monocentric observational study in 17 eyes (16 patients, mean age 42 years, 2 female). SRT was performed with the approved R:GEN laser (Lutronic, South Korea), a micropulsed 527-nm Nd:YLF laser device, with a train of 30 pulses of 1.7 μs at 100-Hz repetition rate at the point of focal leakage determined by fluorescein angiography (FA) at baseline (BSL). Visits on BSL, week 4 (wk4), and week 12 (wk12) included best corrected visual acuity (BCVA, logMar), central retinal thickness (CRT) on spectral domain optical coherence tomography (SD-OCT), and FA. Statistical analysis was performed by pair-by-pair comparisons of multiple observations in each case with Bonferroni correction for multiple testing. (IBM SPSS Statistics 25®). RESULTS: Mean CRT at BSL was 387.69 ± 110.4 μm. CRT significantly decreased by 106.31 μm in wk4 (95%-KI: 21.42-191.2; p = 0.01), by 133.63 μm in wk12 (95%-KI: 50.22-217.03; p = 0.001) and by 133.81 μm (95%-KI: 48.88-218.75; p = 0.001) compared to BSL. Treatment success defined as complete resolution of SRF occurred at wk4 in 7/17 eyes (35.3%) and at wk12 in 10/17 eyes (58.8%). Re-SRT was performed in 7/17 eyes (41.2%) after an average of 107.14 ± 96.59 days. Treatment success after Re-SRT was observed in 4/6 eyes (66.6%, 12 weeks after Re-SRT). Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. Notably, eyes with treatment success showed better BCVA at all timepoints and gained more letters compared to failures. CONCLUSION: Single or repetitive SRT may be an effective and safe treatment in 2 of 3 patients suffering from acute persistent CSC after 6 months of symptoms or more. We observed complete resolution of SRF in around 60% of eyes 12 weeks after first SRT treatment and also 12 weeks after Re-SRT treatment in eyes with persistent or recurrent SRF. Results on the long-term course after SRT are still pending.},
keywords = { Central serous chorioretinopathy; Fluorescein angiography; Micropulse laser; OCT; Persistent acute disease; Selective retina treatment; Subretinal fluid. },
   year = {2021},
   type = {Journal Article}
}
M. Ahrens, C. Idel, P. König, G. Hüttmann, and H. Schulz-Hildebrandt,
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI:10.1117/12.2578787
File: 12.2578787
Bibtex: BibTeX
@inproceedings{10.1117/12.2578787,

title = {Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination},

author = {Martin Ahrens and Christian Idel and Peter K\"{o}nig and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},

editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter},

url = {https://doi.org/10.1117/12.2578787},

doi = {10.1117/12.2578787},

year  = {2021},

date = {2021-01-01},

booktitle = {Endoscopic Microscopy XVI},

volume = {11620},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
E. Richert, J. Papenkort, C. von der Burchard, A. Klettner, P. Arnold, R. Lucius, R. Brinkmann, C. Framme, J. Roider, and J. Tode,
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
File: s12886-021-02188-8
Bibtex: BibTeX
@article{Richert2021,
   title        = {Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy},
   author       = {Richert, E;Papenkort, J;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Framme, C;Roider, J and Tode, J},
   year         = 2021,
   journal      = {BMC Ophthalmology},
   volume       = {21(1)},
   pages        = 412,
   issn         = {1471-2415},
   url          = {https://doi.org/10.1186/s12886-021-02188-8},
   keywords     = {Selective retina therapy (SRT), Thermal stimulation of the retina (TSR),  Age- related macular  degeneration (AMD), Regeneration, Rejuvenation},
   type         = {Journal Article}
}
H. Seifert,
Single pulse optoacoustic temperature measurement, in ECBO , 2021.
DOI:10.1117/12.2615897
Bibtex: BibTeX
@inproceedings{Seifert2021,
   author = {Seifert, E;Abbas, H. S. and Brinkman, R},
   title = {Single pulse optoacoustic temperature measurement},
   booktitle = {ECBO},
DOI = {10.1117/12.2615897},
year = {2021},
   type = {Conference Proceedings}
}
V. Kleymann, M. Schaller, M. Wilson, M. Mordmüller, R. Brinkmann, K. Worthmann, and M. Müller,
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
DOI:https://doi.org/10.1016/j.ifacol.2021.08.552
File: S2405896321013276
Bibtex: BibTeX
@article{Kleyman2021,
   author = {Kleyman, V;Schaller, M;Wilson, M;Mordmüller, M;Brinkmann, R;Worthmann, K and Müller, M.A.},
   title = {State and parameter estimation for model-based retinal laser treatment⁎⁎The collaborative project ”Temperature controlled retinal laser treatment” is funded by the German Research Foundation (DFG) under the project number 430154635 (MU 3929/3-1, WO 2056/7-1, BR 1349/6-1). MS was also funded by the DFG (grant WO 2056/2-1, project number 289034702). KW gratefully acknowledges funding by the German Research Foundation (DFG; grant WO 2056/6-1, project number 406141926)},
   journal = {IFAC-PapersOnLine},
   volume = {54(6)},
 
   pages = {244-250},
   ISSN = {2405-8963},
   DOI = {https://doi.org/10.1016/j.ifacol.2021.08.552},
   url = {https://www.sciencedirect.com/science/article/pii/S2405896321013276},
   year = {2021},
   type = {Journal Article}
}
A. Coker, and V. Yakovlev,
Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions, Photonics Research , vol. 9 (3), pp. 416-423, 2021.
DOI:10.1364/PRJ.411980
Bibtex: BibTeX
@article{Coker2021,
   author = {Coker, Z. N.;Liang, Xiao-Xuan;Kiester, A. S.;Noojin, G. D.;Bixler, J. N.;Ibey, B. L.;Vogel, A. and Yakovlev, V. V.},
   title = {Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions},
   journal = {Photonics Research},
   volume = {9 (3)},
   pages = {416-423},
   DOI = {10.1364/PRJ.411980},
 
   year = {2021},
   type = {Journal Article}
}
M. Mordmüller,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
File: 12.2615851
Bibtex: BibTeX
@inproceedings{Mordmüller2021,
   author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R},
   title = { Towards Model-based Control Techniques for Retinal Laser
Treatment Using Only One Laser},
   booktitle = {ECBO},
url = {https://doi.org/10.1117/12.2615851},
year = {2021},
   type = {Conference Proceedings}
}
M. Mordmüller, V. Kleymann, M. Schaller, M. Wilson, D. Theisen-Kunde, K. Worthmann, M. Müller, and R. Brinkmann,
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
File: aot-2021-0041
Bibtex: BibTeX
@article{Mordmüller-2021,
   author = {Mordmüller, M;Kleyman, V;Schaller, M;Wilson, M;Theisen-Kunde, D;Worthmann, K;Müller, M.A and Brinkmann, R},
   title = {Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate},
   journal = {Advanced Optical Technologies},
Keywords = {extended Kalman filter; laser-coagulation; model predictive control; ophthalmology; photo-acoustics},
  
   url = {https://doi.org/10.1515/aot-2021-0041},
   year = {2021},
   type = {Journal Article}
}
B. Ibey, and N. Linz,
Front Matter: Volume 11640, in SPIE BiOS , SPIE, 2021.
File: 12.2596605
Bibtex: BibTeX
@inproceedings{Linz2021,
   author = {Ibey, B L and Linz, N},
   title = {Front Matter: Volume 11640},
   booktitle = {SPIE BiOS},
Year = {2021},
   publisher = {SPIE},
   volume = {11640},
   url = {https://doi.org/10.1117/12.2596605},
   type = {Conference Proceedings}
}
M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann, and H. Schulz-Hildebrandt,
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
DOI:10.1364/BOE.425001
Bibtex: BibTeX
@article{Münter2021,
   author = {M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann and H. Schulz-Hildebrandt},
   title = {Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast},
   journal = {BiomedOptE},
   volume = {12(10)},
   Keywords = {CMOS cameras,Full field optical coherence tomography,High numerical aperture optics, Image processing,In vivo imaging,Medical imaging,Ag-Huber},
   pages = {6024-6039},
   DOI = {10.1364/BOE.425001},
  
   year = {2021},
   type = {Journal Article}
}
C. Burri, A. Hutfilz, L. Grimm, S. Salzmann, P. Arnold, B. Považay, C. Meier, A. Ebneter, D. Theisen-Kunde, and R. Brinkmann,
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
DOI:https://doi.org/10.3390/app11125535
File: 5535
Bibtex: BibTeX
@article{Burri2021,
   author = {Burri, C;Hutfilz, A;Grimm, L;Salzmann, S;Arnold, P;Považay, B;Meier, C;Ebneter, A;Theisen-Kunde, D and Brinkmann, R},
   title = {Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery},
   journal = {Applied Sciences},
   volume = {11(12)},
   
   pages = {5535},
   ISSN = {2076-3417},
   DOI = { https://doi.org/10.3390/app11125535},
   url = {https://www.mdpi.com/2076-3417/11/12/5535},
   year = {2021},
keywords = {selective retina therapy; viability assay; photocoagulation; microbubble formation;
thermomechanical damage; fringe washout; coherence-loss},
   type = {Journal Article}
}
D. Theisen-Kunde, W. Draxinger, M. Bonsanto, P. Strenge, N. Detrez, R. Huber, and R. Brinkmann,
1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery, in European Conferences on Biomedical Optics 2021 (ECBO) , Optica Publishing Group, 2021. pp. ETu4A.2.
Weblink: https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETu4A.2
File: abstract.cfm
Bibtex: BibTeX
@inproceedings{Theisen-Kunde:21,
author = {D. Theisen-Kunde and W. Draxinger and M. M. Bonsanto and Paul Strenge and Nicolas Detrez and R. Huber and R. Brinkmann},
booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {Clinical applications; Fourier domain mode locking; Optical coherence tomography; Optical fibers; Three dimensional reconstruction; White light},
pages = {ETu4A.2},
publisher = {Optica Publishing Group},
title = {1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery},
year = {2021},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETu4A.2},
doi = {10.1364/ECBO.2021.ETu4A.2},
abstract = {A 1.6 MHz Fourier-domain mode-locked (FDML) optical coherence tomography (OCT) was adapted to an OR-Microscope for clinical application in neurosurgery. 3D-volume scans at video rate are envisaged with approximately 50{\textmu}m lateral and 20{\textmu}m axial resolution.},
}
S. Jäckle, T. Eixmann, F. Matysiak, M. Sieren, M. Horn, H. Schulz-Hildebrandt, G. Hüttmann, and T. Pätz,
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
DOI:doi:10.1515/cdbme-2021-1004
File: cdbme-2021-1004
Bibtex: BibTeX
@article{Jaeckle2021c,
author = {J{\"{a}}ckle, Sonja and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and P{\"{a}}tz, Torben},
doi = {doi:10.1515/cdbme-2021-1004},
journal = {Current Directions in Biomedical Engineering},
year = {2021},
number = {1},
pages = {17--20},
title = {{3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair:}},
url = {https://doi.org/10.1515/cdbme-2021-1004},
volume = {7},
}
R Schenk, and S Kassumeh,
Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography, Tvst , vol. 10 (13), pp. 22-22, 2021.
DOI:10.1167/tvst.10.13.22
Bibtex: BibTeX
@article{Schenk-2021,
   author = {Schenk, M S;Wartak, A;Buehler, V;Zhao, J;Tearney, G J;Birngruber, R and Kassumeh, S},
   title = {Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography},
   journal = {Tvst},
keywords = {corneal nerves; micro–optical coherence tomography; subbasal plexus},
   volume = {10 (13)},
   pages = {22-22},
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.10.13.22},

   year = {2021},
   type = {Journal Article}
}

E. Seifert, J. Tode, A. Pielen, D. Theisen-Kunde, C. Framme, J. Roider, Y. Miura, R. Birngruber, and R. Brinkmann,
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
File: S2213597921000756
Bibtex: BibTeX
@article{Seifert2021,
   author = {Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R},
   title = {Algorithms for optoacoustically controlled selective retina therapy (SRT)},
   journal = {Photoacoustics},
Keywords = {SRT; Lasers in medicine; Ophthalmology; RPE; Selectivity; Algorithm; Retina therapy; Optoacoustics; Feedback},
   volume = {25},
   pages = {100316},
   ISSN = {2213-5979},
   url = {https://www.sciencedirect.com/science/article/pii/S2213597921000756},
   year = {2021},
   type = {Journal Article}
}
J. F. Vanholsbeeck, and A. Thambyah,
Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography, in Optical Elastography and Tissue Biomechanics VIII , Kirill V. Larin and Giuliano Scarcelli, Eds. SPIE, 2021.
DOI:10.1117/12.2587181
Bibtex: BibTeX
@inproceedings{10.1117/12.2587181,
author = {F. Vanholsbeeck, M. Goodwin, M. Klufts, J. Workman and A. Thambyah},
title = {{Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography}},
volume = {11645},
booktitle = {Optical Elastography and Tissue Biomechanics VIII},
editor = {Kirill V. Larin and Giuliano Scarcelli},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
abstract = {Non-invasive identification, understanding and evaluation of articular cartilage damage is paramount for osteoarthritis researcher and clinician alike. Using polarisation sensitive optical coherence tomography together with impact and creep load, we use a range of metrics including birefringence to detect early signs of cartilage degeneration and gain new insights into the physiology of joint tissues},
year = {2021},
doi = {10.1117/12.2587181},
}
S. Lotz, C. Grill, M. Göb, W. Draxinger, J. Kolb, and R. Huber,
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
DOI:10.1117/12.2578514
Bibtex: BibTeX
@inproceedings{LotzLASE2021,
author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber},
title = {{Characterization of the dynamics of an FDML laser during closed-loop cavity length control}},
volume = {11665},
booktitle = {Fiber Lasers XVIII: Technology and Systems},
editor = {Michalis N. Zervas},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {236 -- 241},
abstract = {In Fourier domain mode locked (FDML) lasers, extremely precise and stable matching of the filter tuning period and light circulation time in the cavity is essential for ultra-low noise operation. During the operation of FDML lasers, the ultra-low noise mode can be lost due to temperature drifts of the already temperature stabilized cavity resulting in increased intensity noise. Until now, the filter frequency is continuously regulated to match the changing light circulation time. However, this causes the filter frequency to constantly change by a few mHz and leads to synchronization issues in cases where a fixed filter frequency is desired. We present an actively cavity length controlled FDML laser and a robust and high precision feedback loop algorithm for maintaining ultra-low noise operation. Instead of adapting the filter frequency, the cavity length is adjusted by a motorized free space beam path to match the fixed filter frequency. The closed-loop system achieves a stability of ~0.18 mHz at a sweep repetition rate of ~418 kHz which corresponds to a ratio of 4×10<sup>-10</sup>. We investigate the coherence properties during the active cavity length adjustments and observe no noise increase compared to fixed cavity length. The cavity length control is fully functional and for the first time, offers the possibility to operate an FDML laser in sweet spot mode at a fixed frequency or phase locked to an external clock. This opens new possibilities for system integration of FDML lasers.},
keywords = {AG-Huber_FDML, FDML, Fourier domain mode locking, laser beating, tunable laser, optical coherence tomography, OCT},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2578514}
}
M. Cereda, Y. Douven, K. Faridpooya, G. Hüttmann, T. Eixmann, H. Schulz-Hildebrandt, G. Kronreif, S. van Romunde, M. Beelen, and M. de Smet,
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
DOI:https://doi.org/10.1016/j.xops.2021.100085
Bibtex: BibTeX
@article{Cereda-2021,
   author = {Cereda, M G;Parrulli, S;Douven, Y. G. M.;Faridpooya, K;van Romunde, S;Hüttmann, G;Eixmann, T;Schulz-Hildebrandt, H;Kronreif, G;Beelen, M and de Smet, M D.},
   title = {Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery},
   journal = {Ophthalmology Science},
   volume = {1(4)},
  
   pages = {100085},
   ISSN = {2666-9145},
   DOI = {https://doi.org/10.1016/j.xops.2021.100085},
  
   year = {2021},
   type = {Journal Article}
}
M. Strauch, J. Kolb, C. Rose, N. Merg, C. Kümpers, S. Perner, J. Hundt, S. Karpf, and R. Huber,
Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging, in Virtuelle Pathologietage , 2021.
Bibtex: BibTeX
@Conference{Strauch2021b,
  author    = {M. Strauch, J.P. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf and R. Hubert},
  booktitle = {Virtuelle Pathologietage},
  title     = {Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging},
  year      = {2021},
  keywords  = {AG-Huber_NL},
}
T. Kohlfaerber, M. Pieper, P. König, R. Rahmanzadeh, G. Hüttmann, and H. Schulz-Hildebrandt,
Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A Izatt and James G Fujimoto, Eds. SPIE, 2021.
DOI:10.1117/12.2583811
File: 12.2583811
Bibtex: BibTeX
@inproceedings{10.1117/12.2583811,

title = {Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea},

author = {Tabea Kohlfaerber and Michael M\"{u}nter and Mario Pieper and Peter K\"{o}nig and Ramtin Rahmanzadeh and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},

editor = {Joseph A Izatt and James G Fujimoto},

url = {https://doi.org/10.1117/12.2583811},

doi = {10.1117/12.2583811},

year  = {2021},

date = {2021-01-01},

booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},

volume = {11630},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
H. Schulz-Hildebrandt, M. Ahrens, E. Wilken, C. Holzhausen, P. König, and G. Hüttmann,
Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI:10.1117/12.2575733
File: 12.2575733
Bibtex: BibTeX
@inproceedings{10.1117/12.2575733,

title = {Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast},

author = {Hinnerk Schulz-Hildebrandt and Martin Ahrens and Michael M\"{u}nter and Elisa Wilken and Tabea Kohlf\"{a}rber and Cornelia Holzhausen and Peter K\"{o}nig and Gereon H\"{u}ttmann},

editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter},

url = {https://doi.org/10.1117/12.2575733},

doi = {10.1117/12.2575733},

year  = {2021},

date = {2021-01-01},

booktitle = {Endoscopic Microscopy XVI},

volume = {11620},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
M Hutfilz,
Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths, in ECBO , Osa, 2021.
File: 12.2614437
Bibtex: BibTeX
@inproceedings{Hutfilz2021,
   author = {Hutfilz, A;Theisen-Kunde, D;Bonsanto, M and Brinkman, R},
   title = {Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths},
   booktitle = {ECBO},
url = {https://doi.org/10.1117/12.2614437},
   publisher = {Osa},
year = {2021},
   type = {Conference Proceedings}
}
E. Seifert, K. Philipp, S. Sonntag, D. Theisen-Kunde, S. Grisanti, R. Birngruber, Y. Miura, and R. Brinkmann,
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
DOI:10.1167/iovs.62.3.32
File: iovs.62.3.32
Bibtex: BibTeX
@article{Seifert2021,
   author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R},
   title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {62(3)},
  
   pages = {32-32},
   ISSN = {1552-5783},
   DOI = {10.1167/iovs.62.3.32},
   url = {https://doi.org/10.1167/iovs.62.3.32},
   year = {2021},
   type = {Journal Article}
}
M. Wunderlich, P. Koch, H. Sudkamp, M. Münst, M. Endt, M. Moltmann, and G. Hüttmann,
Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms, in Ophthalmic Technologies XXXI , Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker, Eds. SPIE, 2021. pp. 116231Q.
DOI:10.1117/12.2583030
File: 12.2583030
Bibtex: BibTeX
@inproceedings{10.1117/12.2583030,
author = {Michel Wunderlich and Peter Koch and Helge Sudkamp and Michael M{\"u}nst and Malte vom Endt and Moritz Moltmann and Gereon H{\"u}ttmann},
title = {{Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms}},
volume = {11623},
booktitle = {Ophthalmic Technologies XXXI},
editor = {Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {116231Q},
keywords = {Retinal motion tracking in Off-Axis Full-Field OCT by local analy, Michel Wunderlich, Medizinsches Laserzentrum Lübeck, motion tracking, eye tracking, off-axis full-field time-domain OCT, OCT, retina},
year = {2021},
doi = {10.1117/12.2583030},
URL = {https://doi.org/10.1117/12.2583030}
}
M. Prasuhn, Y. Miura, A. Tura, F. Rommel, V. Kakkassery, S. Sonntag, S. Grisanti, and M. Ranjbar,
Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study, J ClinMed , vol. 10(11), pp. 2418, 2021.
DOI:10.3390/jcm10112418
File: 2418
Bibtex: BibTeX
@article{Prasuhn2021,
   author = {Prasuhn, M;Miura, Y;Tura, A.;Rommel, Felix;Kakkassery, V;Sonntag, S;Grisanti, S and Ranjbar, M},
   title = {Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study},
   journal = {J ClinMed},
   volume = {10(11)},
   
   pages = {2418},
   ISSN = {2077-0383},
   url = {https://www.mdpi.com/2077-0383/10/11/2418},
   year = {2021},
   type = {Journal Article}
}
S. Jäckle, A. Lange, V. Garcia-Vazquez, T. Eixmann, F. Matysiak, M. Sieren, M. Horn, G. Hüttmann, H. Schulz-Hildebrandt, F. Ernst, S. Heldmann, T. Pätz, and T. Preusser,
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
DOI:10.1002/rcs.2327
Bibtex: BibTeX
@article{Jackle2021,
abstract = {Background: In endovascular aneuysm repair (EVAR) procedures, medical instruments are currently navigated with a two-dimensional imaging based guidance requiring X-rays and contrast agent. Methods: Novel approaches for obtaining the three-dimensional instrument positions are introduced. Firstly, a method based on fibre optical shape sensing, one electromagnetic sensor and a preoperative computed tomography (CT) scan is described. Secondly, an approach based on image processing using one 2D fluoroscopic image and a preoperative CT scan is introduced. Results: For the tracking based method, average errors from 1.81 to 3.13 mm and maximum errors from 3.21 to 5.46 mm were measured. For the image-based approach, average errors from 3.07 to 6.02 mm and maximum errors from 8.05 to 15.75 mm were measured. Conclusion: The tracking based method is promising for usage in EVAR procedures. For the image-based approach are applications in smaller vessels more suitable, since its errors increase with the vessel diameter.},
author = {J{\"{a}}ckle, Sonja and Lange, Annkristin and Garcia-Vazquez, Veronica and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and Ernst, Floris and Heldmann, Stefan and P{\"{a}}tz, Torben and Preusser, Tobias},
doi = {10.1002/rcs.2327},
file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Medical Robotics and Computer Assisted Surgery/J{\"{a}}ckle et al. - 2021 - Instrument localisation for endovascular aneurysm repair Comparison of two methods based on tracking systems or.pdf:pdf},
issn = {1478596X},
journal = {International Journal of Medical Robotics and Computer Assisted Surgery},
keywords = {2D/3D registration,3D localisation,computer-assisted surgery,electromagnetic tracking system,endovascular procedures,fibre optical shape sensing},
number = {6},
pages = {e2327},
year = {2021},
title = {{Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging}},
volume = {17}
}
Y. Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO, Nippon Laser Igakkaishi , vol. advpub, 2021.
DOI:10.2530/jslsm.jslsm-42_0008
Bibtex: BibTeX
@article{Miura-3,
   author = {Miura, Y},
   title = {Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO},
   journal = {Nippon Laser Igakkaishi},
   volume = {advpub},
   DOI = {10.2530/jslsm.jslsm-42_0008},
   year = {2021},
   type = {Journal Article}
}
S. Sonntag, E. Seifert, M. Hamann, B. Lewke, D. Theisen-Kunde, S. Grisanti, R. Brinkmann, and Y. Miura,
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
DOI:https://www.mdpi.com/2075-1729/11/6/555
File: 555
Bibtex: BibTeX
@article{Miura2021-2,
   author = {Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y},
   title = {Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States},
   journal = {Life},
   volume = {11(6)},
  keywords = {retinal laser treatment; metabolic change; fluorescence lifetime imaging ophthalmoscopy},
   pages = {555},
   ISSN = {2075-1729},
   url = {https://www.mdpi.com/2075-1729/11/6/555},
   year = {2021},
   type = {Journal Article}
}
A. Krumm,
Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy, in ECBO , 2021.
DOI:https://doi.org/10.1117/12.2614447
Bibtex: BibTeX
@inproceedings{Krumm-2021,
   author = {Krumm, L S;Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W;Merseburger, A S and Brinkman, R},
   title = {Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy},
Year = {2021},
   booktitle = {ECBO},
DOI = {https://doi.org/10.1117/12.2614447},
   type = {Conference Proceedings}
}
A. Kyo, M. Yamamoto, K. Hirayama, T. Kohno, D. Theisen-Kunde, R. Brinkmann, Y. Miura, and S. Honda,
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
DOI:10.1038/s41598-021-88372-8
Bibtex: BibTeX
@article{Kyo-2021,
   author = {Kyo, A.;Yamamoto, M.;Hirayama, K.;Kohno, T.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.},
   title = {Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy},
   journal = {Sci Rep},
   volume = {11(1)},
  
   pages = {8973},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-021-88372-8},
   year = {2021},
   type = {Journal Article}
}

2020

C. von der Burchard, M. Moltmann, J. Tode, C. Ehlken, H. Sudkamp, D. Theisen-Kunde, I. König, G. Hüttmann, and J. Roider,
Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases, Graefe's Archive for Clinical and Experimental Ophthalmology , Dec. 2020.
File: s00417-020-05035-6
Bibtex: BibTeX
@article{von-derBurchard2020,
   author = {von der Burchard, C;Moltmann, M.;Tode, J;Ehlken, C;Sudkamp, H;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J},
   title = {Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   ISSN = {1435-702X},
   
   url = {https://doi.org/10.1007/s00417-020-05035-6},
   year = {2020},
   type = {Journal Article}
}
M. Schmidt, C. Grill, R. Huber, and C. Jirauschek,
Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime, in 2020 International Conference Laser Optics (ICLO) , Nov.2020. pp. 1-1.
DOI:10.1109/ICLO48556.2020.9285488
Bibtex: BibTeX
@INPROCEEDINGS{Schmidt2020ICLO,
  author={M. {Schmidt}, C. {Grill}, R. {Huber} and C. {Jirauschek}},
  booktitle={2020 International Conference Laser Optics (ICLO)}, 
  title={Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime}, 
  year={2020},
keywords={AG-Huber_FDML},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/ICLO48556.2020.9285488},
}
T. Pfeiffer, M. Göb, W. Draxinger, S. Karpf, J. Kolb, and R. Huber,
Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging, Biomed. Opt. Express , vol. 11, no. 11, pp. 6799--6811, Nov. 2020. OSA.
DOI:10.1364/BOE.402477
Bibtex: BibTeX
@article{Pfeiffer:20,
author = {T. Pfeiffer, M. G\"{o}b, W. Draxinger, S. Karpf, J.P. Kolb and R. Huber},
journal = {Biomed. Opt. Express},
keywords = {AG-Huber_OCT; High speed imaging; Image quality; Optical coherence tomography; Swept lasers; Swept sources; Systems design},
number = {11},
pages = {6799--6811},
publisher = {OSA},
title = {Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging},
volume = {11},
month = {Nov},
year = {2020},
doi = {10.1364/BOE.402477},
abstract = {In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze them point by point and describe the appropriate solutions. We prove that coherent averaging is possible at MHz OCT-speed without special interferometer designs or digital phase stabilization. We find, that in our system up to \&\#x223C;100x coherent averaging is possible while achieving a sensitivity increase close to the ideal values. This corresponds to a speed reduction from 3.3 MHz to 33 kHz and a sensitivity gain of 20 dB. We show an imaging comparison between coherent and magnitude averaging of a human finger knuckle joint in vivo with 121\&\#x00A0;dB sensitivity for the coherent case. Further, the benefits of computational downscaling in low sensitivity MHz-OCT systems are analyzed.},
}
E. Richert, C. von der Burchard, A. Klettner, P. Arnold, R. Lucius, R. Brinkmann, J. Roider, and J. Tode,
Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models, 09 2020.
File: S2590153220300112
Bibtex: BibTeX
@article{RN5351,
   author = {Richert, E;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Roider, J and Tode, J},
   title = {Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models},
   journal = {Cytokine: X},
   volume = {2},
   number = {3},
   pages = {100031},
   ISSN = {2590-1532},
   DOI = {https://doi.org/10.1016/j.cytox.2020.100031},
   url = {https://www.sciencedirect.com/science/article/pii/S2590153220300112},
   year = {2020},
   type = {Journal Article}
}
M. Strauch, J. Kolb, D. Weng, M. Wacker, W. Draxinger, N. Merg, J. Hundt, S. Karpf, and R. Huber,
Two-photon microscopy for sectioning-free virtual H&E imaging, in 104. Jahrestagung der Deutschen Gesellschaft fuer Pathologie , 062020.
Weblink: https://www.pathologie-dgp.de/media/Dgp/user_upload/Verhandlungsband_2020_final__kompr._.pdf
Bibtex: BibTeX
@InProceedings{Strauch2020,
  author    = {M. Strauch, J.P. Kolb, D. Weng, M. Wacker, W. Draxinger, N. Merg, J. Hundt, S. Karpf and R. Huber},
  booktitle = {104. Jahrestagung der Deutschen Gesellschaft fuer Pathologie},
  title     = {Two-photon microscopy for sectioning-free virtual {H&E} imaging},
URL = {https://www.pathologie-dgp.de/media/Dgp/user_upload/Verhandlungsband_2020_final__kompr._.pdf},
  year      = {2020},
  keywords  = {AG-Huber_NL},
}
M. Schmidt, T. Pfeiffer, C. Grill, R. Huber, and C. Jirauschek,
Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2020. Optical Society of America.
DOI:10.1364/OSAC.389972
Bibtex: BibTeX
@article{schmidt2020self,
  title={Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers},
  author={M. {Schmidt}, T. {Pfeiffer}, C. {Grill}, R. {Huber} and C. {Jirauschek}},
  journal={OSA Continuum},
  volume={3},
  number={6},
  pages={1589--1607},
  year={2020},
keywords={AG-Huber_FDML},
url={https://doi.org/10.1364/OSAC.389972}, 
  publisher=  {Optical Society of America}
}
M. Strauch,
Tunable Optics: Spectral Imaging and Surface Manipulation on Liquid Lenses, Delft University of Technology, Delft, 03 2020.
DOI:10.4233/uuid:b61aa64e-cba4-44c0-8d16-93440e028611
Bibtex: BibTeX
@PhdThesis{Strauch2020,
  author      = {M. Strauch},
  title       = {Tunable Optics: Spectral Imaging and Surface Manipulation on Liquid Lenses},
  institution = {Delft University of Technology},
  year        = {2020},
  date        = {2020-03-30},
  type        = {phdthesis},
  subtitle    = {Spectral Imaging and Surface Manipulation on Liquid Lenses},
  language    = {English},
  isbn        = {978-94-028-1994-6},
  pagetotal   = {151},
  doi         = {10.4233/uuid:b61aa64e-cba4-44c0-8d16-93440e028611},
  
  abstract    = {This thesis focusses on two aspects of tunable optics: Fabry-P{\'e}rot interferometers with a variable distance between their mirrors and electrowetting liquid lenses. The need for a device to detect child abuse has motivated us to design and build a camera that can detect the chemical composition of the upper skin layers of a bruise using a self-made Fabry-P{\'e}rot interferometer. The research described in the first part of this thesis has shown that wide-angle spectral imaging can be achieved with compact and cost-effective cameras using Fabry-P{\'e}rot interferometers. Designs with a full field of 90° in which the Fabry-P{\'e}rot interferometer is mounted either in front of an imaging system or behind a telecentric lens system are presented and analysed. The dependency of the spectral resolution on the numerical aperture of the lens system is derived and its value as a design criterion is shown. It is shown that the telecentric camera design is preferable over the collimated design for bruise imaging with a Fabry-P{\'e}rot interferometer.The idea to use a liquid lens for spectral imaging has directed the research towards a new concept of controlling surface waves on the surface of a liquid lens. We investigate and model surface waves because they decrease the imaging quality during fast focal switching. We propose a model that describes the surface modes appearing on a liquid lens and that predicts the resonance frequencies. The effects of those surface modes on a laser beam are simulated using geometrical optics and Fresnel propagation, and the model is verified experimentally. The model of the surface oscillations is used to develop a technique to create aspheric surface shapes on commercially available electrowetting liquid lenses. The surface waves on the liquid lens are described by Bessel functions of which a linear combination can be used to create any circularly symmetrical aspheric lens shape at an instant of time. With these surface profiles, one can realise a large set of circularly symmetrical wavefronts and hence intensity distributions of beams transmitted by the lens. The necessary liquid lens actuation to achieve a desired shape is calculated via a Hankel transform and confirmed experimentally. The voltage signal can be repeated at video rate. Measurements taken with a Mach-Zehnder interferometer confirm the model of the surface waves. The capabilities and limitations of the proposed method are demonstrated using the examples of a Bessel surface, spherical aberration, an axicon, and a top hat structure.},
keywords = {AG-Huber},
  address     = {Delft},
  publisher   = {Delft University of Technology},
  school      = {Delft University of Technology},
}
P. Strenge, B. Lange, C. Grill, W. Draxinger, M. Bonsanto, C. Hagel, R. Huber, and R. Brinkmann,
Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV , SPIE, 022020. pp. 82 -- 89.
DOI:10.1117/12.2545659
Bibtex: BibTeX
@inproceedings{Strenge2020,
author = {P. Strenge and B. Lange and C. Grill and W. Draxinger and M. M. Bonsanto and C. Hagel and R. Huber and R. Brinkmann},
title = {{Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis}},
volume = {11228},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {82 -- 89},
keywords = {AG-Huber_OCT, Optical coherence tomography, OCT, FDML Laser, MHz-OCT, brain tumor, brain imaging, neurosurgery},
year = {2020},

URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11228/112282O/Segmented-OCT-data-set-for-depth-resolved-brain-tumor-detection/10.1117/12.2545659.short}
}
C. Grill, S. Lotz, T. Blömker, D. Kastner, T. Pfeiffer, M. Schmidt, W. Draxinger, C. Jirauschek, and R. Huber,
Beating of two FDML lasers in real time, in Fiber Lasers XVII: Technology and Systems , Liang Dong, Eds. SPIE, 022020. pp. 132 -- 138.
DOI:10.1117/12.2545794
Bibtex: BibTeX
@inproceedings{Grill2020,
author = {C. {Grill}, S. {Lotz}, T. {Blömker}, D. {Kastner}, T. {Pfeiffer}, S. {Karpf}, M. {Schmidt}, W. {Draxinger}, C. 
 {Jirauschek} and R. {Huber}},
title = {{Beating of two FDML lasers in real time}},
volume = {11260},
booktitle = {Fiber Lasers XVII: Technology and Systems},
editor = {Liang Dong},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {132 -- 138},
keywords = {AG-Huber_FDML, FDML laser, fiber lasers, beat signal, OCT, Optical Coherence Tomography, Fourier domain mode locking},
year = {2020},
doi = {10.1117/12.2545794},

}
L. Cecchetti, T. Wang, A. Hoogendoorn, K. Witberg, J. Lighthart, J. Daemen, H. van Beusekom, T. Pfeiffer, R. Huber, J. Wentzel, A. van der Steen, and G. van Soest,
In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT, The International Journal of Cardiovascular Imaging , vol. 36, no. 6, pp. 1021-1029, 02 2020. Springer Science and Business Media LLC.
DOI:10.1007/s10554-020-01796-7
Bibtex: BibTeX
@article{Cecchetti2020,
  doi = {10.1007/s10554-020-01796-7},
  url = {https://doi.org/10.1007/s10554-020-01796-7},
  year = {2020},
  month = feb,
  publisher = {Springer Science and Business Media {LLC}},
  volume = {36},
  number = {6},
  pages = {1021--1029},
  author = {Leonardo Cecchetti and Tianshi Wang and Ayla Hoogendoorn and Karen T. Witberg and Jurgen M. R. Ligthart and Joost Daemen and Heleen M. M. van Beusekom and Tom Pfeiffer and Robert A. Huber and Jolanda J. Wentzel and Antonius F. W. van der Steen and Gijs van Soest},
  title = {In-vitro and in-vivo imaging of coronary artery stents with Heartbeat {OCT}},
  journal = {The International Journal of Cardiovascular Imaging}
}
G. Elhardt,
Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography, Translational Vision Science & Technology , vol. 9(5), pp. 6-6, 2020.
File: tvst.9.5.6
Bibtex: BibTeX
@article{Birngruber2020,
   author = {Elhardt, C;Wertheimer, C M.;Wartak, A;Zhao, J;Leung, H M;Kassumeh, S A.;Yin, B;Tearney, G J. and Birngruber, R},
   title = {Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography},
   journal = {Translational Vision Science & Technology},
   volume = {9(5)},
  
   pages = {6-6},
   ISSN = {2164-2591},
   Keywords = {optical coherence tomography; micro-OCT; imaging;corneal nerves; diabetes},
   url = {https://doi.org/10.1167/tvst.9.5.6},
   year = {2020},
   type = {Journal Article}
}
Jalali,
Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates, Nature Communications , vol. 11(1), pp. 2062, 2020.
File: s41467-020-15618-w
Bibtex: BibTeX
@article{Karpf-2020,
   author = {S. Karpf, C.T. Riche, D. Di Carlo, A. Goel, W.A. Zeiger, A. Suresh, C. Portera-Cailliau B. and Jalali},
   title = {Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates},
   journal = {Nature Communications},
   volume = {11(1)},
  keywords={},
   pages = {2062},
   ISSN = {2041-1723},
  
   url = {https://doi.org/10.1038/s41467-020-15618-w},
   year = {2020},
   type = {Journal Article}
}
A. López-Marín, G. Springeling, R. Beurskens, H. van Beusekom, A. van der Steen, A. Koch, B. Bouma, and T. Wang,
Shadow-free motorized capsule enables accurate beam positioning and sectorized OCT imaging of the esophagus, in Endoscopic Microscopy XV , International Society for Optics and Photonics, 2020. pp. 112140O.
File: 12.2545689
Bibtex: BibTeX
@inproceedings{Lopez2020,
   author = {López-Marín, Antonio;Springeling, Geert;Beurskens, Robert;Van Beusekom, Heleen;van der Steen, Antonius;Koch, Arjun D;Bouma, Brett E;Huber, Robert A;Van Soest, Gijs and Wang, Tianshi},
   title = {Shadow-free motorized capsule enables accurate beam positioning and sectorized OCT imaging of the esophagus},
   booktitle = {Endoscopic Microscopy XV},
   publisher = {International Society for Optics and Photonics},
   volume = {11214},
   pages = {112140O},
url = { https://doi.org/10.1117/12.2545689},
   type = {Conference Proceedings}
}
G Deen,
Thermo-elastic optical coherence microscopy, in Proc.SPIE , International Society for Optics and Photonics, 2020. pp. 112520H.
DOI:10.1117/12.2550998
File: 12.2550998
Bibtex: BibTeX
@inproceedings{Deen2020,
   author = {Deen, A D;Pfeiffer, T;H, van Beusekom.;Essers, J;Huber, R;van der Steen, A.F.W.;van Soest, G and Wang, T},
   title = {Thermo-elastic optical coherence microscopy},
   booktitle = {Proc.SPIE},
   volume = {11252},
abstarct = {The absorption of laser pulses by tissue leads not only to the generation of acoustic waves, but also to nanometer
to sub-micrometer scale displacement. After the initial expansion, a quasi-steady state is achieved in a few
microseconds. Previously we introduced the concept of thermo-elastic optical coherence tomography (TE-OCT)
to \visualise" the rapid thermo-elastic expansion by measuring the Doppler phase shift rather than \listening"
to the acoustic wave as in photoacoustic imaging. In this study, we built a microscopic setup for high-speed
3D TE-OCT imaging, by means of thermo-elastic optical coherence microscopy (TE-OCM). The repetition rate
of pulsed laser was set to 100 Hz and the line rate of the OCT system is 1.5 MHz. The OCT beam and the
laser pulse were focused upon the same location on the sample FWHM spot sizes of 300 m for the pulsed laser
and 40 m FWHM for the OCT beam. For each laser pulse, an M-mode OCT image consisting of 90 A-lines
was acquired. The Doppler phase shift was extracted by comparing the phase signal before and after the pulse
arrival. Within 6 minutes, a 3D TE-OCM image (10 x 10 x 4 mm3) can be acquired and processed. Imaging
experiments were carried out in swine meat using 1210 nm excitation wavelength to highlight lipid in tissue.
The results show that no signicant displacement was detected in swine muscle while strong displacement was
observed in lipid, owing to the optical absorption features. Furthermore, fatty tissue is easily identied in the
3D TE-OCM image while the conventional OCT images provides the structural information.},

   pages = {112520H},
   DOI = {10.1117/12.2550998},
   url = {https://doi.org/10.1117/12.2550998},
   type = {Conference Proceedings}
}
T. Wang, A. Deen, H. van Beusekom, and A. van der Steen,
Thermo-elastic optical coherence microscopy, in Advanced Chemical Microscopy for Life Science and Translational Medicine , International Society for Optics and Photonics, 2020. pp. 112520H.
DOI:https://doi.org/10.1117/12.2550998
File: 12.2550998.short
Bibtex: BibTeX
@inproceedings{Deen2020,
   author = {Deen, Aaron Doug;Pfeiffer, Tom;Van Beusekom, Heleen;Essers, Jeroen;Huber, Robert;van der Steen, Antonius FW;Van Soest, Gijs and Wang, Tianshi},
   title = {Thermo-elastic optical coherence microscopy},
   booktitle = {Advanced Chemical Microscopy for Life Science and Translational Medicine},
   publisher = {International Society for Optics and Photonics},
url = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11252/112520H/Thermo-elastic-optical-coherence-microscopy/10.1117/12.2550998.short}
   volume = {11252},
   pages = {112520H},
   type = {Conference Proceedings}
}
S. Jäckle, V. Garcia-Vazquez, T. Eixmann, F. Matysiak, F. von Haxthausen, M. Sieren, H. Schulz-Hildebrandt, G. Hüttmann, F. Ernst, M. Kleemann, and T. Pätz,
Three-dimensional guidance including shape sensing of a stentgraft system for endovascular aneurysm repair, Int J Comp Assis Radiology and Surgery , 2020.
ISBN:1861-6429
File: s11548-020-02167-2
Bibtex: BibTeX
@article{jackle2020,
title = {Three-dimensional guidance including shape sensing of a stentgraft system for endovascular aneurysm repair},
author = {Jäckle,S; Garcia-Vazquez,V; Eixmann, T; Matysiak, F; von Haxthausen,F; Sieren; M m; Schulz-Hildebrandt, H;  H\"{u}ttmann, G; Ernst, F; Kleemann, M and P\"{a}tz, T},
url = {https://doi.org/10.1007/s11548-020-02167-2},

isbn = {1861-6429},
year = {2020},
date = {2020-04-06},
journal = {Int J  Comp Assis Radiology and Surgery},
abstract = {During endovascular aneurysm repair (EVAR) procedures, medical instruments are guided with two-dimensional (2D) fluoroscopy and conventional digital subtraction angiography. However, this requires X-ray exposure and contrast agent is used, and the depth information is missing. To overcome these drawbacks, a three-dimensional (3D) guidance approach based on tracking systems is introduced and evaluated.},
keywords = {HSH},
pubstate = {published},
tppubtype = {article}
}
M. Yamamoto, Y. Miura, A. Kyo, K. Hirayama, T. Kohno, D. Theisen-Kunde, R. Brinkmann, and S. Honda,
Selective retina therapy for subretinal fluid associated with choroidal nevus, Amer J Ophthalm Case Rep , vol. 19, pp. 100794, 2020.
DOI:https://doi.org/10.1016/j.ajoc.2020.100794
Bibtex: BibTeX
@article{yamamoto2020,
   author = {Yamamoto, M;Miura, Y;Kyo, A;Hirayama, K;Kohno, T;Theisen-Kunde, D;Brinkmann, R and Honda, S},
   title = {Selective retina therapy for subretinal fluid associated with choroidal nevus},
   journal = {Amer J Ophthalm Case Rep},
   volume = {19},
   pages = {100794},
   ISSN = {2451-9936},
keywords = {Laser therapy, Choroidal tumor, Retinal pigment epithelium, Retinal disorder},
   DOI = {https://doi.org/10.1016/j.ajoc.2020.100794},
   
   year = {2020},
   type = {Journal Article}
}
K. Hirayama, M. Yamamoto, T. Kohno, A. Kyo, D. Theisen-Kunde, R. Brinkmann, Y. Miura, and S. Honda,
Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome, Graefes Arch Clin Exp Ophthalmol , vol. 259, pp. 387-393, 2020.
DOI:10.1007/s00417-020-04931-1
Bibtex: BibTeX
@article{Hirayama2020,
   author = {Hirayama, K.;Yamamoto, M.;Kohno, T.;Kyo, A.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.},
   title = {Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   ISSN = {0721-832x},
 volume = {259},
   pages = {387-393},
   DOI = {10.1007/s00417-020-04931-1},
   year = {2020},
   type = {Journal Article}
}
J. Kilin, and J. Wolf,
Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles, ACS Nano , vol. 14(4), pp. 4087-4095, 2020.
File: acsnano.9b08813
Bibtex: BibTeX
@article{Vogel-2020,
   author = {Kilin, V;Campargue, G;Fureraj, I;Sakong, S;Sabri, T;Riporto, F;Vieren, A;Mugnier, Y;Mas, C;Staedler, D;Collins, J M;Bonacina, L;Vogel, A;Capobianco, J A. and Wolf, J-P},
   title = {Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles},
   journal = {ACS Nano},
   volume = {14(4)},
   
   pages = {4087-4095},
   ISSN = {1936-0851},
   
   url = {https://doi.org/10.1021/acsnano.9b08813},
   year = {2020},
   type = {Journal Article}
}
M. Yamamoto, Y. Miura, K. Hirayama, T. Kohno, D. Kabata, D. Theisen-Kunde, R. Brinkmann, and S. Honda,
Predictive factors of outcome of selective retina therapy for diabetic macular edema, International Ophthalmology , 2020.
File: s10792-020-01288-6
Bibtex: BibTeX
@article{Miura2020-2,
   author = {Yamamoto, M;Miura, Y;Hirayama, K;;Kohno, T;Kabata, D;Theisen-Kunde, D;Brinkmann, R and Honda, S;},
   title = {Predictive factors of outcome of selective retina therapy for diabetic macular edema},
   journal = {International Ophthalmology},
   ISSN = {1573-2630},
   
   url = {https://doi.org/10.1007/s10792-020-01288-6},
   year = {2020},
   type = {Journal Article}
}
R Wartak, and G. Tearney,
Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures, Biomedical Optics Express , vol. 11(10), pp. 5920-5933, 2020.
DOI: https://doi.org/10.1364/BOE.402971
Bibtex: BibTeX
@article{Wartak2020,
   author = {Wartak, A;Schenk, M S.;Bühler, V;Kassumeh, S A.;Birngruber, R and Tearney, G J.},
   title = {Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures},
keywords = {High numerical aperture optics,Image metrics,Image processing,Image quality,Optical coherence tomography,Optical imaging},
   journal = {Biomedical Optics Express},
   volume = {11(10)},
  
DOI = { https://doi.org/10.1364/BOE.402971},
   pages = {5920-5933},
   
   year = { 2020},
   type = {Journal Article}
}
E. Richert, J. Papenkort, A. Klettner, J. Tode, S. Koinzer, R. Brinkmann, C. Fink, T. Roeder, R. Lucius, and J. Roider,
Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR), Lasers in Surgery and Medicine , 2020.
DOI:DOI 10.1002/lsm.23288
Bibtex: BibTeX
@article{Richert2020,
   author = {Richert, E;Papenkort, J;Klettner, A;Tode, J;Koinzer, S;Brinkmann, R;Fink, C;Roeder, T;Lucius, R. and Roider, J},
   title = {Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)},
   journal = {Lasers in Surgery and Medicine},
Keywords = {age‐related macular degeneration; thermal stimulation therapy of the retinal pigment epithelium;
matrix metalloproteases; pigment epithelium derived factor; retinal pigment epithelium; vascular endothelial
growth factor; transforming growth factor‐β},
   DOI = {DOI 10.1002/lsm.23288},
   year = {2020},
   type = {Journal Article}
}
R. Wertheimer,
Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia, J Refractive Surg , no. 6(36), pp. 406--413, 2020.
File: refractive-changes-after-corneal-stromal-filler-injection-for-the-correction-of-hyperopia
Bibtex: BibTeX
@article{Wertheimer2020,
author = {Wertheimer, C M; Brandt, K; Kaminsky, S; Elhardt, C; Kassumeh, S A; Pham, L; Schulz-Hildebrandt, H; Priglinger, S; Anderson, R R and Birngruber, R},

url = {https://www.healio.com/ophthalmology/journals/jrs/2020-6-36-6/%7B8e6aaf40-922c-4998-9c7b-39b47135ec61%7D/refractive-changes-after-corneal-stromal-filler-injection-for-the-correction-of-hyperopia},
journal = {J Refractive Surg},
number = {6(36)},
pages = {406--413},
title = {Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia},

date = {2020-06-14},
year = {2020},
keywords ={mOCT, HSH}
}
Y. Miura,
Retinal Pigment Epithelium Organ Culture, in Retinal Pigment Epithelium in Health and Disease , Springer, 2020, pp. 307-324.
File: 978-3-030-28384-1_18
Bibtex: BibTeX
@inbook{Miura2020,
   author = {Miura, Yoko},
   title = {Retinal Pigment Epithelium Organ Culture},
   booktitle = {Retinal Pigment Epithelium in Health and Disease},
   publisher = {Springer},
   pages = {307-324},
   year = {2020},
   type = {Book Section},
URL = { https://link.springer.com/chapter/10.1007/978-3-030-28384-1_18}
}
M. Müller, R. Rahmanzadeh, T. Tran, J. Kappelhoff, E. Akam, P. Caravan, T. Jüstel, K. Held, R. Anderson, and M. Purschke,
Particle size of X-ray pumped UVC emitting nanoparticles defines intracellular localization and biological activity against cancer cells, Particle and Particle Systems Characterization , 2020.
DOI:10.1002/ppsc.202000201
File: 0
Bibtex: BibTeX
@article{Müller2020,
   author = {Müller M;Rahmanzadeh R;Tran T;Kappelhoff J;Akam EA;Caravan P;Jüstel T;Held KD;Anderson R and M, and Purschke},
   title = {Particle size of X-ray pumped UVC emitting nanoparticles defines intracellular localization and biological activity against cancer cells},
   journal = {Particle and Particle Systems Characterization },
   year = {2020},
   type = {Journal Article},
url = { https://onlinelibrary.wiley.com/toc/15214117/0/0}
}
A Holzhey, and M. Ranjbar,
Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss, Journal of visualized experiments: JoVE , no. 158, 2020.
DOI:10.3791/60542
Bibtex: BibTeX
@article{Holzhey2020,
   author = {Holzhey, A;Sonntag, S;Rendenbach, J;Ernesti, J S;Kakkassery, V;Grisanti, S;Reinholz, F;Freidank, S;Vogel, A and Ranjbar, M},
   title = {Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss},
   journal = {Journal of visualized experiments: JoVE},
   number = {158},
   ISSN = {1940-087X},
DOI = {10.3791/60542 },
   year = {2020},
   type = {Journal Article}
}
H. Schneider, M. Ahrens, M. Strumpski, C. Rüger, M. Häfer, G. Hüttmann, D. Theisen-Kunde, H. Schulz-Hildebrandt, and R. Haak,
An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations, J Clin Med , vol. 9(10), 2020.
DOI:10.3390/jcm9103257
Bibtex: BibTeX
@article{schneider2020,
   author = {Schneider, H.;Ahrens, M.;Strumpski, M.;Ruger, C.;Hafer, M.;Huettmann, G.;Theisen-Kunde, D.;Schulz-Hildebrandt, H. and Haak, R.},
   title = {An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations},
   journal = {J Clin Med},
   volume = {9(10)},
   keywords = {OCT; intraoral probe; carious lesions; caries diagnosis; dental restorations},
   ISSN = {2077-0383 (Print)
2077-0383 (Linking)},
   DOI = {10.3390/jcm9103257},
   
   year = {2020},
   type = {Journal Article}
}
N Koop,
Beständig durch Mikrodefekte, Pharma+Food , 2020.
File:
Bibtex: BibTeX
@article{Koop2020,
   author = {Koop, N},
   title = {Beständig durch Mikrodefekte},
   journal = {Pharma+Food},
   url = { https://www.pharma-food.de/bestaendig-durch-mikrodefekte/},
   year = {2020},
   type = {Journal Article}
}
C. Yao, F. Rudnitzki, Y. He, Z. Zhang, G. Hüttmann, and R. Rahmanzadeh,
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
DOI:10.1002/jbio.202000017
Bibtex: BibTeX
@article{Rahmanzadeh-2020,
   author = {Yao, C;Rudnitzki, F;He, Y;Zhang, Z;Hüttmann, G and Rahmanzadeh, R},
   title = {Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods},
   journal = {JBio},
   
   ISSN = {1864-063X},
   DOI = {10.1002/jbio.202000017},
  Year = {2020},
   type = {Journal Article}
}
M. Luecking, R. Brinkmann, S. Ramos, W. Stork, and N. Heussner,
Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage, CompBioMed , vol. 122, pp. 103835, 2020.
DOI:https://doi.org/10.1016/j.compbiomed.2020.103835
Bibtex: BibTeX
@article{brinkmann2020-2,
   author = {Luecking, M;Brinkmann, R;Ramos, Sc;Stork, W and Heussner, N},
   title = {Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage},
   journal = {CompBioMed},
   volume = {122},
   pages = {103835},
   ISSN = {0010-4825},
   DOI = {https://doi.org/10.1016/j.compbiomed.2020.103835},
 
   year = {2020},
   type = {Journal Article}
}
A. Rakhymzhan, L. Reuter, R. Raspe, D. Bremer, J. Heidelin, V. Andresen, R. Günther, R. Leben, S. Cheremukhin, H. Schulz-Hildebrandt, M. Bixel, R. Adams, H. Radbruch, G. Hüttmann, A. Hauser, and R. Niesner,
Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging, Cytometry Part A , vol. 97, no. 5, pp. 515-527, 2020.
DOI:10.1002/cyto.a.24012
Bibtex: BibTeX
@article{Schulz-Hildebrandt-2020,
   author = {Rakhymzhan, A;Reuter, L;Raspe, R;Bremer, D;Günther, R;Leben, R;Heidelin, J;Andresen, V;Cheremukhin, S;Schulz-Hildebrandt, H;Bixel, M G.;Adams, R H.;Radbruch, H;Hüttmann, G;Hauser, A E. and Niesner, R A.},
   title = {Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging},
  year = {2020},
   journal = {Cytometry Part A},
   volume = {97},
   number = {5},
   pages={515-527},
   ISSN = {1552-4922},
   DOI = {10.1002/cyto.a.24012},
   type = {Journal Article}
}
R. Kassumeh,
Corneal Stromal Filler Injection as a Novel Approach to Correct Presbyopia—An Ex Vivo Pilot Study, TVST , vol. 9(7), pp. 30-30, 2020.
File: tvst.9.7.30
Bibtex: BibTeX
@article{Kassumeh2020,
   author = {Kassumeh, S;Luther, J K.;Wertheimer, C M.;Brandt, K;Schenk, M S.;Priglinger, S G.;Wartak, A;Apiou-Sbirlea, G.;Anderson, R. R. and Birngruber, R},
   title = {Corneal Stromal Filler Injection as a Novel Approach to Correct Presbyopia—An Ex Vivo Pilot Study},
   journal = {TVST},
   volume = {9(7)},
  keywords = { presbyopia correction; corneal filler; refractive surgery; femtosecond laser; hyaluronic acid; bifocality},

   pages = {30-30},
   ISSN = {2164-2591},
   
   url = {https://doi.org/10.1167/tvst.9.7.30},
   year = {2020},
   type = {Journal Article}
}
V. Matkivsky, A. Moiseev, P. Shilyagin, A. Rodionov, H. Spahr, C. Pfäffle, G. Hüttmann, D. Hillmann, and G. Gelikonov,
Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function, Journal of Biophotonics , vol. 13(10), pp. e202000112, 2020.
DOI:10.1002/jbio.202000112
Bibtex: BibTeX
@article{Matkivsky2020,
   author = {Matkivsky, V;Moiseev, A;Shilyagin, P;Rodionov, A;Spahr, H;Pfäffle, C;Hüttmann, G;Hillmann, D and Gelikonov, G},
   title = {Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function},
   journal = {Journal of Biophotonics},
   volume = {13(10)},
   pages = {e202000112},
   ISSN = {1864-063X},
   DOI = {10.1002/jbio.202000112},
   year = {2020},
   type = {Journal Article}
}
M. Münter, M. Pieper, M. Casper, M. Ahrens, T. Kohlfaerber, R. Rahmanzadeh, P. König, G. Hüttmann, and H. Schulz-Hildebrandt,
Dynamic contrast in scanning microscopic OCT, Optic Letters , 2020.
File: 2003.00006
Bibtex: BibTeX
@article{Münter2020,
   author = {Münter, M;Endt, M v;Pieper, M;Casper, M;Ahrens, M;Kohlfaerber, T;Rahmanzadeh, R;König, P;Hüttmann, G and Schulz-Hildebrandt, H},
   title = {Dynamic contrast in scanning microscopic OCT},
   journal = {Optic Letters},
url = {https://arxiv.org/abs/2003.00006},
   year = {2020},
   type = {Journal Article}
}
P. Enzian, C. Schell, A. Link, C. Malich, R. Pries, B. Wollenberg, and R. Rahmanzadeh,
Optically controlled drug release from light-sensitive liposomes with the new photosensitizer 5,10-DiOH, Molecular Pharmaceutics , 2020.
DOI:10.1021/acs.molpharmaceut.9b01173
Bibtex: BibTeX
@article{Enzian2020,
   author = {Enzian, P.;Schell, C.;Link, A.;Malich, C.;Pries, R.;Wollenberg, B and Rahmanzadeh, R},
   title = {Optically controlled drug release from light-sensitive liposomes with the new photosensitizer 5,10-DiOH},
   journal = {Molecular Pharmaceutics},
   ISSN = {1543-8384},
   DOI = {10.1021/acs.molpharmaceut.9b01173},
   
   year = {2020},
   type = {Journal Article}
}
E. Richert, S. Bartsch, J. Hillenkamp, F. Treumer, J. Tode, C. von der Burchard, R. Brinkmann, A. Klettner, and J. Roider,
Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums, Klin Monatsbl Augenheilkd , vol. 237(02), pp. 192-201, 2020.
DOI:10.1055/a-0838-5633
File: a-0838-5633
Bibtex: BibTeX
@article{Brinkmann2020,
   author = {Richert, E;Bartsch, S;Hillenkamp, J;Treumer, F;Tode, J;von der Burchard, C;Brinkmann, R;Klettner, A K and Roider, J},
   title = {Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums},
   journal = {Klin Monatsbl Augenheilkd},
   volume = {237(02)},
   
   pages = {192-201},
   ISSN = {0023-2165},
   DOI = {10.1055/a-0838-5633},
   year = {2020},
   type = {Journal Article}
}
M. Strauch, J. Kolb, N. Merg, J. Hundt, S. Karpf, and R. Huber,
Evaluation of two-photon fluorescence microscopy for sectioning-free H&E imaging of different tissues, in 32nd Congress of the ESP and XXXIII International Congress of the IAP , 2020.
DOI:10.1007/s00428-020-02938-x
Bibtex: BibTeX
@InProceedings{Strauch2020a,
  author    = {M. Strauch, J.P. Kolb, N. Merg, J. Hundt, S. Karpf and R. Huber},
  booktitle = {32nd Congress of the ESP and XXXIII International Congress of the IAP},
  title     = {Evaluation of two-photon fluorescence microscopy for sectioning-free {H&E} imaging of different tissues},
  year      = {2020},
  keywords  = {AG-Huber_NL},
}
T. Fischer, A. Klinger, D. Smolinski, R. Orzekowsky-Schröder, F. Nitzsche, A. Vogel, G. Hüttmann, and A. Gebert,
High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , pp. 1-8, 2020.
File: s00441-020-03167-z
Bibtex: BibTeX
@article{Fischer2020,
   author = {Fischer, T;Klinger, A;von Smolinski, D;Orzekowsky-Schroeder, R;Nitzsche, F;Bölke, T;Vogel, A;Hüttmann, G and Gebert, A},
   title = {High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures},
   journal = {Cell and Tissue Research},
   pages = {1-8},
   ISSN = {1432-0878},
   url = {https://doi.org/10.1007/s00441-020-03167-z},
   year = {2020},
   type = {Journal Article}
}
G Pieper, and P K\"{o}nig,
Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice, American Journal of Physiology-Lung Cellular and Molecular Physiology , vol. 318, no. 3, pp. 518-524, 2020. American Physiological Society Rockville, MD.
DOI:10.1152/ajplung.00287.2019
Bibtex: BibTeX
@article{pieper2020intravital,
title = {Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice},
author = {Pieper,P; Schulz-Hildebrandt, H; Mall,Marcus A; H\"{u}ttmann, G and K\"{o}nig, P},
doi = {10.1152/ajplung.00287.2019},
year = {2020},
date = {2020-02-26},
journal = {American Journal of Physiology-Lung Cellular and Molecular Physiology},
volume = {318},
number = {3},
pages = {518-524},
publisher = {American Physiological Society Rockville, MD},
abstract = {Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical coherence tomography (mOCT) is sensitive to detect and compare in vivo effects of inhaled isotonic saline, hypertonic saline and bicarbonate on mucus mobilization and clearance in Scnn1b-transgenic mice with muco-obstructive lung disease. In vivomOCT imaging showed that inhaled isotonic saline-induced rapid mobilization of mucus that was mainly transported as chunks from the lower airways of Scnn1b-transgenic mice. Hypertonic saline mobilized a significantly greater amount of mucus that showed a more uniform distribution compared to isotonic saline. Addition of bicarbonate to isotonic saline had no effect on mucus mobilization, but also led to a more uniform mucus layer compared to treatment with isotonic saline alone. mOCT can detect differences in response to mucus mobilizing interventions in vivo, and may thus support the development of more effective therapies for patients with muco-obstructive lung diseases.},
keywords = {mOCT,OCT},
pubstate = {published},
tppubtype = {article}
}
V. Kleymann, H. Gernandt, K. Worthmann, H. Abbas, R. Brinkmann, and M. Müller,
Modeling parameter for temperature controlled retinal laser therapies, DeGruyter-at-Automatisierungstechnik , vol. 68(11), pp. 953-966, 2020.
File: article-p953.xml
Bibtex: BibTeX
@article{Kleymann2020,
   author = {Kleymann, V;Gernandt, H;Worthmann, K;Hossam, S.A;Brinkmann, R and Müller, A.M},
   title = {Modeling parameter for temperature controlled retinal laser therapies },
   journal = {DeGruyter-at-Automatisierungstechnik},
   volume = {68(11)},
keywords = {retinal photocoagulation, parametric model order
reduction, identification},
   pages = {953-966},
  URL = {https://www.degruyter.com/view/journals/auto/68/11/article-p953.xml},
   year = {2020},
   type = {Journal Article}
}

M Palczewska, and K Palczewski,
Noninvasive two-photon optical biopsy of retinal fluorophores, Proceedings of the National Academy of Sciences , pp. 202007527, 2020.
DOI:10.1073/pnas.2007527117
Bibtex: BibTeX
@article{Palczewska-2020,
   title        = {Noninvasive two-photon optical biopsy of retinal fluorophores},
   author       = {Palczewska, G;Boguslawski, J;Stremplewski, P;Kornaszewski, L;Zhang, J;Dong, Z;Liang, Xiao-Xuan;Gratton, E;Vogel, A;Wojtkowski, M and Palczewski, K},
   year         = 2020,
   journal      = {Proceedings of the National Academy of Sciences},
   pages        = 202007527,
   doi          = {10.1073/pnas.2007527117},
   type         = {Journal Article}
}
B. Ibey, and N. Linz,
Optical Interactions with Tissue and Cells XXXI, in Proc. of SPIE Vol , 2020. pp. 1123801-1.
DOI:10.1117/12.2569811
ISBN:ISBN: 9781510632394
Bibtex: BibTeX
@inproceedings{Linz2020,
   author = {Ibey, B L and Linz, N},
   title = {Optical Interactions with Tissue and Cells XXXI},
   booktitle = {Proc. of SPIE Vol},
   volume = {11238},
   pages = {1123801-1},
year = {2020},
   ISBN = {ISBN: 9781510632394},
   DOI = {10.1117/12.2569811},
   type = {Conference Proceedings}
}
S. Freidank, and N. Linz,
Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery, TVST , vol. 9(10), pp. 22-22, 2020.
File: tvst.9.10.22
Bibtex: BibTeX
@article{Freidank2020,
   author = {Freidank, S;Vogel, A and Linz, N},
   title = {Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery},
   journal = {TVST},
   volume = {9(10)},
   
   pages = {22-22},
   ISSN = {2164-2591},
 
   url = {https://doi.org/10.1167/tvst.9.10.22},
   year = {2020},
   type = {Journal Article}
}

2019

M. Horn, S. Jäckle, F. von Haxthausen, T. Eixmann, H. Schulz-Hildebrandt, G. Hüttmann, J. Bouchagiar, F. Matysiak, M. Kaschwich, M. Kleemann, F. Ernst, V. Garcia-Vazquez, and T. Pätz,
First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures, European Journal of Vascular and Endovascular Surgery , vol. 58, no. 6, pp. e610--e611, Dec. 2019. W.B. Saunders.
DOI:10.1016/J.EJVS.2019.09.091
Bibtex: BibTeX
@proceedings{Horn2019b,
title = {First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures},
author = {Marco Horn and Sonja J\"{a}ckle and Felix von Haxthausen and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Juljan Bouchagiar and Florian Matysiak and Mark Kaschwich and Markus Kleemann and Floris Ernst and Ver\'{o}nica Garc\'{i}a-V\'{a}zquez and Torben P\"{a}tz},
doi = {10.1016/J.EJVS.2019.09.091},
issn = {1078-5884},
year  = {2019},
date = {2019-12-13},
journal = {European Journal of Vascular and Endovascular Surgery},
volume = {58},
number = {6},
pages = {e610--e611},
publisher = {W.B. Saunders},
keywords = {Sensing, Fiber},
pubstate = {published},
tppubtype = {proceedings}
}
P. Enzian, A. Link, C. Schell, C. Malich, and R. Rahmanzadeh,
Light-induced permeabilization of liposomes, vol. 11070, 08 2019. Proc.SPIE.
File: 12.2526071
Bibtex: BibTeX
@Proc{Enzian2019,
   author = {Enzian, P.;Link, A.;Schell, C.;Malich, C. and Rahmanzadeh, R.},
   title = {Light-induced permeabilization of liposomes},
   publisher = {Proc.SPIE},
   volume = {11070},
   series = {17th International Photodynamic Association World Congress},
   
   url = {https://doi.org/10.1117/12.2526071},
   year = {2019},
   type = {Book}
}
H. Spahr, C. Pfäffle, S. Burhan, L. Kutzner, F. Hilge, G. Hüttmann, and D. Hillmann,
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific report , vol. 9, 08 2019.
DOI:10.1038/s41598-019-47979-8
Bibtex: BibTeX
@article{RN5217,
   author = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck},
   title = {Phase-sensitive interferometry of decorrelated speckle patterns},
   journal = {Scientific Reports},
   volume = {9},
   number = {1},
   pages = {11748},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-019-47979-8},
   url = {https://doi.org/10.1038/s41598-019-47979-8},
   year = {2019},
   type = {Journal Article}
}
A. López-Marín, G. Springeling, R. Beurskens, H. van Beusekom, A. van der Steen, A. Koch, B. Bouma, R. Huber, G. van Soest, and T. Wang,
Motorized capsule for shadow-free OCT imaging and synchronous beam control, Opt Lett , vol. 44, no. 15, pp. 3641-3644, 08 2019. Optica Publishing Group.
DOI:10.1364/OL.44.003641
Bibtex: BibTeX
@article{Lopez-Marin:19,
author = {Antonio L\'{o}pez-Mar\'{i}n and Geert Springeling and Robert Beurskens and Heleen van Beusekom and Antonius F. W. van der Steen and Arjun D. Koch and Brett E. Bouma and Robert Huber and Gijs van Soest and Tianshi Wang},
journal = {Opt. Lett.},
keywords = {Image reconstruction; Light beams; Magnetic fields; Optical coherence tomography; Optical imaging; Reflector design},
number = {15},
pages = {3641--3644},
publisher = {Optica Publishing Group},
title = {Motorized capsule for shadow-free OCT imaging and synchronous beam control},
volume = {44},
month = {Aug},
year = {2019},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-44-15-3641},
doi = {10.1364/OL.44.003641},
abstract = {We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments using the capsule. The results show that the capsule can potentially be a useful tool for diagnostic OCT imaging and OCT-guided biopsy and therapy of the esophagus.},
}
Y. Miura, W. Draxinger, C. Grill, T. Pfeiffer, S. Grisanti, and R. Huber,
MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. SPIE, 072019. pp. 110780E.
DOI:10.1117/12.2527123
Bibtex: BibTeX
@inproceedings{10.1117/12.2527123,
author = {Yoko Miura and Wolfgang Draxinger and Christin Grill and Tom Pfeiffer and Salvatore Grisanti and Robert Huber},
title = {{MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye
}},
volume = {11078},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III},
editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {110780E},
abstract = {MHz-OCT systems based on FDML swept laser sources combined with the massive parallel processing capabilities of modern computer hardware enable volumetric imaging, processing and stereoscopic display at video rates. The increasing image quality and speed might enable new fields of application where the volumetric OCT completely replaces stereoscopic microscopes instead of being a mere supplement. Aside from the depth resolving capability, a particular advantage is the ability to display a whole image volume from arbitrary points of view without the need to move the actual microscope or to rotate the patient’s eye. Purely digital microscopy is already offered as alternative to traditional through-an-eyepiece surgical microscope. We explore the use of virtual reality to present digital OCT microscopy images to a trained surgeon, carrying out a series of surgical procedures ex-vivo on a porcine eye model.},
keywords = {virtual reality, surgery guidance , real-time OCT, user experience},
year = {2019},
doi = {10.1117/12.2527123},
URL = {https://doi.org/10.1117/12.2527123}
}
M. Göb, T. Pfeiffer, and R. Huber,
Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , aciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. 072019. pp. 110780Y.
DOI:10.1117/12.2526796
Bibtex: BibTeX
@inproceedings{10.1117/12.2526796,
author = {Madita G{\"o}b and Tom Pfeiffer and Robert Huber},
title = {{Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy}},
volume = {11078},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III},
editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {110780Y},
abstract = {We demonstrate a preliminary setup of a combined MHz-OCT and RGB narrowband reflection microscope and investigate the performance of the new RGB branch and different display modes of colored OCT data sets.},
keywords = {MHz OCT, multi-spectral imaging, Optical Coherence Tomography, Fourier Domain Mode Locked , FDML, RGB, Color },
year = {2019},
doi = {10.1117/12.2526796},
URL = {https://doi.org/10.1117/12.2526796}
}
J. Klee, J. Kolb, C. Grill, W. Draxinger, T. Pfeiffer, and R. Huber,
Zero roll-off retinal MHz-OCT using an FDML-laser, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , SPIE, 072019. pp. 110780S.
DOI:10.1117/12.2527034
File: 12.2527034.short
Bibtex: BibTeX
@inproceedings{10.1117/12.2527034,
author = {Julian Klee and Jan Philip Kolb and Christin Grill and Wolfgang Draxinger and Tom Pfeiffer and Robert Huber},
title = {{Zero roll-off retinal MHz-OCT using an FDML-laser}},
volume = {11078},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III},
editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {110780S},
abstract = {Optical coherence tomography (OCT) applications like ultra-widefield and full eye-length imaging are of high interest for various diagnostic purposes. In swept-source OCT these techniques require a swept light source, which is coherent over the whole imaging depth. We present a zero roll-off 1060 nm Fourier Domain Mode Locked-Laser (FDML-Laser) for retinal OCT imaging at 1.7 MHz A-scan rate and first long-range imaging results with it. Several steps such as improved dispersion compensation and frequency regulation were performed and will be discussed. Besides virtually no loss in OCT signal over the maximum depth range of 4.6 mm and very good dynamic range was observed. Roll-off measurements show no decrease of the point-spread function (PSF), while maintaining a high dynamic range.},
keywords = {optical coherence tomography, OCT, tunable laser, Fourier Domain Mode Locking, FDML, MHz OCT},
year = {2019},
doi = {10.1117/12.2527034},
URL = {https://doi.org/10.1117/12.2527034}
}
D. Weng, H. Hakert, T. Blömker, J. Kolb, M. Strauch, M. Eibl, P. Lamminger, S. Karpf, and R. Huber,
Sub-Nanosecond Pulsed Fiber Laser for 532nm Two-Photon Excitation Fluorescence (TPEF) Microscopy of UV Transitions, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , IEEE, 062019. pp. 1-1.
DOI:10.1109/CLEOE-EQEC.2019.8872571
Bibtex: BibTeX
@INPROCEEDINGS{8872571,
  author={Weng, Daniel and Hakert, Hubertus and Blömker, Torben and Kolb, Jan Philip and Strauch, Matthias and Eibl, Matthias and Lamminger, Philipp and Karpf, Sebastian and Huber, Robert},
  booktitle={2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Sub-Nanosecond Pulsed Fiber Laser for 532nm Two-Photon Excitation Fluorescence (TPEF) Microscopy of UV Transitions}, 
  year={2019},
  volume={},
  number={},
  pages={1-1},
  abstract={Summary form only given. Two-photon microscopy is a powerful technique for in vivo imaging, due to its high penetration depth and axial sectioning. Usually excitation wavelengths in the near infrared are used. However, most fluorescence techniques for live cell imaging require labeling with exogenous fluorophores. It has been shown that shorter wavelengths can be used to excite the autofluorescence of endogenous proteins, e.g. tryptophan. Recently we demonstrated a fully fiber-based laser source built around a directly modulated, ytterbium amplified 1064 nm laser diode with sub-nanosecond pulses for two-photon imaging [2]. The overall system enables to capture high-speed fluorescence lifetime imaging (FLIM) with single pulse excitation. Here, we extend the spectral range of this laser source by frequency doubling it to 532nm to achieve two-photon excited fluorescence microscopy (TPM) in the ultraviolett (UV) range to harness endogenous autofluorescence. In this presentation we explore first TPM results of tryptophan to investigate signal levels and fi delity before transitioning to biological tissues. It has been shown that TPM of endogenous tryptophan can be used to visualize immune system activity in vivo. Our laser source could be a cheap, flexible and fiber-based alternative to the OPO-based Ti:Sa Lasers currently employed. The basic concept of our design is to shift the wavelength of the pulsed fiber-based master oscillator power amplifier (MOPA) by second-harmonic generation (SHG) using phase-matching in a KTP crystal. This generates a coherent output at 532nm at a maximal peak power of 500W. We achieved a maximum conversion efficiency of about 17%. After the SHG module, the 532nm light is coupled into a single-mode fiber and delivered to a home built microscope. A 40x microscope objective is used to excite the sample and epi-collect the fluorescence. The fluorescence is recorded on a UV-enhanced photomultiplier tube (PMT). For a proof of concept measurement, crystalized tryptophan was imaged. Here we show signals of pure tryptophan, with laser parameters of 1MHz repetition rate and 100ps pulse duration. We used spectral bandpass fi lters in order to detect only fluorescence signal, however, from crystalized tryptophan we observed an unexpected short lifetime. We have recently shown that we can shift our laser output from 1064nm to longer wavelengths. By shifting to 1180nm and frequency doubling to 590nm a more efficient fluorescence excitation of tryptophan can be achieved. In the future we aim at in vivo imaging with our setup.},
  keywords={},
  doi={10.1109/CLEOE-EQEC.2019.8872571},
  ISSN={},
  month={June}}
J. Kolb, W. Draxinger, J. Klee, T. Pfeiffer, M. Eibl, T. Klein, W. Wieser, and R. Huber,
Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates, PLOS ONE , vol. 14, no. 7, pp. e0213144, 03 2019.
DOI:10.1371/journal.pone.0213144
Bibtex: BibTeX
@article{Kolb2019,
   author = {Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R},
   title = {Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates},
   journal = {J pone},
 keywords = {AG-Huber_OCT},
   url = {https://doi.org/10.1371/journal.pone.0213144},
   pages = {e0213144},
   ISSN = {1932-6203},
   
   year = {2019},
   type = {Journal Article}
}
H. Spahr, C. Pfäffle, G. Hüttmann, and D. Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt. Lett. , vol. 44, no. 6, pp. 1315--1318, 03 2019. Optica Publishing Group.
DOI:10.1364/OL.44.001315
File: abstract.cfm
Bibtex: BibTeX
@article{RN5085,
   author = {Spahr, H;Pfäffle, C;Hüttmann, G and Hillmann, D},
   title = {Artifacts in speckle tracking and multi-aperture
Doppler OCT imaging of lateral motion},
   journal = {Optics letters},
   volume = {44(5)},
   pages = {1315-1318},
   DOI = {https://doi.org/10.1364/OL.44001315},
   url = {https://doi.org/10.1364/OL.44001315},
   year = {2019},
   type = {Journal Article}
}
J. Kolb, D. Weng, H. Hakert, M. Eibl, W. Draxinger, T. Meyer-Zedler, T. Gottschall, R. Brinkmann, R. Birngruber, J. Popp, J. Limpert, S. Karpf, and R. Huber,
Virtual HE histology by fiber-based picosecond two-photon microscopy, in Multiphoton Microscopy in the Biomedical Sciences XIX , Ammasi Periasamy; Peter T. C. So; Karsten König, Eds. International Society for Optics and Photonics, 022019. pp. 108822F.
DOI:10.1117/12.2507866
Bibtex: BibTeX
@inproceedings{10.1117/12.2507866,
author = {Jan Philip Kolb and Daniel Weng and Hubertus Hakert and Matthias Eibl and Wolfgang Draxinger and Tobias Meyer and Thomas Gottschall and Ralf  Brinkmann and Reginald Birngruber and J{\"u}rgen Popp and Jens Limpert and Sebastian Nino Karpf and Robert Huber},
title = {{Virtual HE histology by fiber-based picosecond two-photon microscopy}},
volume = {10882},
booktitle = {Multiphoton Microscopy in the Biomedical Sciences XIX},
editor = {Ammasi Periasamy and Peter T. C. So and Karsten K{\"o}nig},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {108822F},
abstract = {Two-Photon Microscopy (TPM) can provide three-dimensional morphological and functional contrast in vivo. Through proper staining, TPM can be utilized to create virtual, HE equivalent images and thus can improve throughput in histology-based applications. We previously reported on a new light source for TPM that employs a compact and robust fiber-amplified, directly modulated laser. This laser is pulse-to-pulse wavelength switchable between 1064 nm, 1122 nm, and 1186 nm with an adjustable pulse duration from 50ps to 5ns and arbitrary repetition rates up to 1MHz at kW-peak powers. Despite the longer pulse duration, it can achieve similar average signal levels compared to fs-setups by lowering the repetition rate to achieve similar cw and peak power levels. The longer pulses lead to a larger number of photons per pulse, which yields single shot fluorescence lifetime measurements (FLIM) by applying a fast 4 GSamples/s digitizer. In the previous setup, the wavelengths were limited to 1064 nm and longer. Here, we use four wave mixing in a non-linear photonic crystal fiber to expand the wavelength range down to 940 nm. This wavelength is highly suitable for imaging green fluorescent proteins in neurosciences and stains such as acridine orange (AO), eosin yellow (EY) and sulforhodamine 101 (SR101) used for histology applications. In a more compact setup, we also show virtual HE histological imaging using a direct 1030 nm fiber MOPA.},
keywords = {Multiphoton Microscopy, Four Wave Mixing, FWM, Histology, Laser, Non Linear Microscopy, Two Photon Microscopy, JenLab Young Investigator Award},
year = {2019},
doi = {10.1117/12.2507866},
URL = {https://doi.org/10.1117/12.2507866}
}
P. South, and S. Boppart,
Local wavefront mapping in tissue using computational adaptive optics OCT, Opt Lett 44(5) , no. 5, pp. 1186--1189, 2019. OSA.
DOI:10.1364/OL.44.001186
Bibtex: BibTeX
@article{South:19,
author = { South,F A; Liu, Y-Z; Huang, P-C and Kohlfärber, T and Boppart, S A},
journal = { Opt Lett 44(5)},
pages = {1186--1189},
keywords = {Adaptive optics; Image metrics; Image quality; Refractive index; Speckle noise; Wavefront aberrations},
number = {5},
 
publisher = {OSA},
title = {Local wavefront mapping in tissue using computational adaptive optics OCT},


year = {2019},
doi = {10.1364/OL.44.001186},
abstract = {The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.},
}
K. Barcikowski, and A. Vogel,
Materials synthesis in a bubble, MRS Bulletin , vol. 44 (5), pp. 382--391, 2019.
DOI:10.1557/mrs.2019.107
Bibtex: BibTeX
@article{Vogel2019-2,
    title        = {Materials synthesis in a bubble},
    author       = {Barcikowski, Stephan;Plech, Anton;Suslick, Kenneth S. and Vogel, Alfred},
    year         = 2019,
    journal      = {MRS Bulletin},
    volume       = {44 (5)},
    pages        = {382--391},
    doi          = {10.1557/mrs.2019.107},
    issn         = {0883-7694},
    type         = {Journal Article}
}
D Casper,
Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography, J Biomed Opt , pp. 046005 - 1 - 11, 2019.
File: 1.JBO.24.4.046005
Bibtex: BibTeX
@article{
citation_key = { Casper19},
author = { Casper, M;  Schulz-Hildebrandt, H; Evers, M; Birngruber,R; Manstein, D and Hüttmann, G},
title = {Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography},

journal = {J Biomed Opt},

pages = {046005 - 1 - 11},
year = {2019},

URL = {https://doi.org/10.1117/1.JBO.24.4.046005},
eprint = {}
}
D. Kastner, T. Blömker, T. Pfeiffer, C. Grill, M. Schmidt, C. Jirauschek, and R. Huber,
Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser, in 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference , Optical Society of America, 2019. pp. 1-1.
DOI:10.1109/CLEOE-EQEC.2019.8872860
Bibtex: BibTeX
@inproceedings{Kastner:19,
author = {Kastner, D; Bl\"{o}mker, T; Pfeiffer, T; Grill, C; Schmidt, M; Jirauschek, C and Huber, R},
booktitle = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference},
journal = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference},
keywords = {Fourier domain mode locking; Image quality; Optical coherence tomography; Phase noise; Ring lasers; Tunable lasers},
pages = {cj_7_5},
publisher = {Optical Society of America},
title = {Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser},
year = {2019},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
doi = { 10.1109/CLEOE-EQEC.2019.8872860},
abstract = {Fourier Domain Mode Locking (FDML) lasers are light sources that generate a sequence of narrowband optical frequency sweeps at the fundamental or harmonic of the cavity repetition rate \[1\]. This frequency swept output can also be considered as a sequence of strongly chirped, long pulses. FDML lasers are mainly used in swept source optical coherence tomography (SS-OCT), a medical imaging technique. The coherence length of the source, i.e. the intra-sweep phase stability of an FDML sweep, is decisive for the image quality and performance of OCT imaging \[2\].},
}
R. Schmidt, and C. Jirauschek,
Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers, pp. 1-1, 2019.
DOI:10.1109/CLEOE-EQEC.2019.8873213
Bibtex: BibTeX
@article{Schmidt2019,
   author = {Schmidt, Mark;Pfeiffer, Tom;Grill, Christin;Huber, Robert and Jirauschek, Christian},
   title = {Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers},
   pages = {1-1},
   DOI = {10.1109/CLEOE-EQEC.2019.8873213},
   year = {2019},
   type = {Book},
booktitle = { 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference}
}

Z Liang, and A Vogel,
Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water, Opt Expr , pp. 4672-4693, 2019.
DOI:10.1364/OE.27.004672
Bibtex: BibTeX
@article{Liang2019,
   author = {Liang, X-X; Zhang, Z and Vogel, A},
   title = {Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water},
   journal = {Opt Expr},
   
   
   pages = {4672-4693},
   DOI = {10.1364/OE.27.004672},
   
   year = {2019},
   type = {Journal Article}
}
B Burri, and C Meier,
Optical coherence tomography controlled selective retina therapy with a novel microsecond laser., .... SPIE, 2019.
File: 12.2526720
Bibtex: BibTeX
@book{Burri2019,
   author = {Burri, C;Hutfilz, A;Grimm, L;Arnold, P;Ebneter, A;Brinkmann, R;Theisen-Kunde, D;Považay, B and Meier, C},
   title = {Optical coherence tomography controlled selective retina therapy with a novel microsecond laser},
   publisher = {SPIE},
   volume = {11079},
keywords = {Selective retina therapy, Retinal pigment epithelium, (170.0170) Medical optics and biotechnology, (170.4500) Optical coherence tomography, (170.4460) Ophthalmic optics and devices, instrumentation, (170.4470) Ophthalmology},
   series = {European Conferences on Biomedical Optics},
   url = {https://doi.org/10.1117/12.2526720},
   year = {2019},
   type = {Book}
}
F. Strittmatter, M. Eisel, R. Brinkmann, B. Lange, J. Cordes, and R. Sroka,
Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned, Translational Biophotonics , vol. n/a, no. n/a, pp. e201900029, 2019.
DOI:10.1002/tbio.201900029
File: tbio.201900029
Bibtex: BibTeX
@article{Brinkmann2020,
   author = {Strittmatter, F;Eisel, M; Brinkmann, R; Cordes, J;Lange, B and Sroka, R},
   title = {Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned},
   journal = {Translational Biophotonics},
   volume = {n/a},
   number = {n/a},
   pages = {e201900029},
   ISSN = {2627-1850},
   DOI = {10.1002/tbio.201900029},
   url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/tbio.201900029},
   year = {2019},
   type = {Journal Article}
}
A. Klettner, and Y. Miura,
Porcine RPE/choroidal explant cultures., .... 2019.
ISBN:978-1-4939-8669-2
File: 978-1-4939-8669-9_8
Bibtex: BibTeX
@book{Miura2019,
   author = {Klettner, A and  Miura, Y},
   title = {Porcine RPE/choroidal explant cultures},
   pages = {109-118 },
journal = {Weber B., Langmann T., Retinal Degeneration. Methods in Molecular Biology: 1834},
   ISBN = {978-1-4939-8669-2},
  URL = {https://doi.org/10.1007/978-1-4939-8669-9_8},
   year = {2019},
   type = {Book}
}
G. Spahr, and D. Hillmann,
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific Reports , vol. 9(1), pp. 11748, 2019.
File: s41598-019-47979-8
Bibtex: BibTeX
@article{Spahr-2019,
   title        = {Phase-sensitive interferometry of decorrelated speckle patterns},
   author       = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck},
   year         = 2019,
   journal      = {Scientific Reports},
   volume       = {9(1)},
   pages        = 11748,
   issn         = {2045-2322},
   url          = {https://doi.org/10.1038/s41598-019-47979-8},
   type         = {Journal Article}
}
R. Rahmanzadeh, F. Rudnitzki, and G. Hüttmann,
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
DOI:10.1002/jbio.201800460
File: jbio.201800460
Bibtex: BibTeX
@article{Rahmanzadeh-2019,
   author = {Rahmanzadeh, R;Rudnitzki, F and Hüttmann, G},
   title = {Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes},
   journal = {Journal of Biophotonics},
   Year = {2019},
   pages = {e201800460},
   ISSN = {1864-063X},
   DOI = {10.1002/jbio.201800460},
   url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201800460},
   type = {Journal Article}
}
Y. Miura, E. Seifert, J. Rehra, K. Kern, D. Theisen-Kunde, M. Denton, and R. Brinkmann,
Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study, Int J Hyperth , pp. 1-7, 2019.
File: 02656736.2019.1590653
Bibtex: BibTeX
@article{Miura2019/4,
   author = {Miura, Y;Seifert, E;Rehra, J;Kern, K;Theisen-Kunde, D;Denton, M and Brinkmann, R},
   title = {Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study},
   journal = {Int J Hyperth},
   pages = {1-7},
   ISSN = {0265-6736},
  
   url = {https://doi.org/10.1080/02656736.2019.1590653},
   year = {2019},
   type = {Journal Article}
}
M. Strauch, J. Kolb, D. Weng, M. Wacker, W. Draxinger, S. Karpf, and R. Huber,
Sectioning-Free Virtual H&E Imaging of Tissue Samples with Two-Photon Microscopy, in 31st Congress of the ESP , 2019.
DOI:10.1007/s00428-019-02631-8
Bibtex: BibTeX
@InProceedings{Strauch2019,
  author    = {Strauch, Matthias and Kolb, Jan Philip and Weng, Daniel and Wacker, Melanie and Draxinger, Wolfgang and Karpf, Sebastian and Huber, Robert},
  booktitle = {31st Congress of the ESP},
  title     = {Sectioning-Free Virtual H&E Imaging of Tissue Samples with Two-Photon Microscopy},
  year      = {2019},
  keywords  = {AG-Huber_NL},
}
T. Kepp, C. Droigk, M. Casper, M. Evers, G. Hüttmann, N. Salma, D. Manstein, M. Heinrich, and H. Handels,
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks, Biomed Opt Expr 10(7) , pp. 3484-3496, 2019.
DOI:10.1364/BOE.10.003484
File: BOE.10.003484
Bibtex: BibTeX
@article{Hüttmann2019,
   author = {Kepp, T;Droigk, C;Casper, M;Evers, M;Hüttmann, G;Salma, N;Manstein, D;Heinrich, M P. and Handels, H},
   title = {Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks},
   journal = {Biomed Opt Expr 10(7)},
  
   pages = {3484-3496},
   DOI = {10.1364/BOE.10.003484},
   url = {https://doi.org/10.1364/BOE.10.003484},
   year = {2019},
   type = {Journal Article}
}
B. Považay, R. Brinkmann, M. Stoller, and R. Kessler,
Selective Retina Therapy, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 237-259.
DOI:https://doi.org/10.1007/978-3-030-16638-0_11
ISBN:978-3-030-16638-0
File: 978-3-030-16638-0_11
Bibtex: BibTeX
@inbook{Brinkmann2019,
   author = {Považay, Boris;Brinkmann, Ralf;Stoller, Markus and Kessler, Ralf},
   title = {Selective Retina Therapy},
   booktitle = {High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics},
   editor = {Bille, Josef F.},
   publisher = {Springer International Publishing},
   address = {Cham},
   pages = {237-259},
   ISBN = {978-3-030-16638-0},
  
   url = {https://doi.org/10.1007/978-3-030-16638-0_11},
   year = {2019},
   type = {Book Section}
}
C. Pfäffle, H. Spahr, L. Kutzner, S. Burhan, F. Hilge, Y. Miura, G. Hüttmann, and D. Hillmann,
Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina, Optics Letters 44(23) , pp. 5671-5674, 2019.
DOI:10.1364/OL.44.005671
Bibtex: BibTeX
@article{Pfäffle2019,
   author = {Pfäffle, C;Spahr, H;Kutzner, L;Burhan, S;Hilge, F;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina},
   journal = {Optics Letters 44(23)},
 
   pages = {5671-5674},
   DOI = {10.1364/OL.44.005671},
   
   year = {2019},
   type = {Journal Article}
}
R. Wang, and G. van Soest,
Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography, IEEE Transactions on Medical Imaging , vol. 39, no. 5, pp. 1535-1544, 2019.
Bibtex: BibTeX
@article{Wang2019-2,
   author = {Wang, Tianshi;Pfeiffer, Tom;Daemen, Joost;Mastik, Frits;Wieser, Wolfgang;van der Steen, AFW;Huber, Robert and van Soest, Gijs},
   title = {Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography},
   journal = {IEEE Transactions on Medical Imaging},
   volume = {39},
   number = {5},
   pages = {1535-1544},
   ISSN = {0278-0062},
   year = {2019},
   type = {Journal Article}
}
R Tode, and J Roider,
Thermische Stimulation der Retina: von der translationalen Forschung zur experimentellen technischen Umsetzung, Spitzenforschung in der Ophthalmologie , vol. 117.DOG Kongress, pp. 172-175, 2019.
File:
Bibtex: BibTeX
@article{Tode2019,
   author = {Tode, J;von der Burchard, C;Richert, E;Klettner, A;Brinkman, R and Roider, J},
   title = {Thermische Stimulation der Retina: von der translationalen Forschung zur experimentellen technischen Umsetzung},
   journal = {Spitzenforschung in der Ophthalmologie},
   volume = {117.DOG Kongress},
   pages = {172-175},
   ISSN = {1861-4620},
   url = {https://www.dog.org/?cat=276},
   year = {2019},
   type = {Journal Article}
}
B Jalali,
Time-stretch LiDAR as a spectrally scanned time-of-flight ranging camera, Nature Photonics , 2019.
File: 337692338_Time-stretch_LiDAR_as_a_spectrally_scanned_time-of-flight_ranging_camera
Bibtex: BibTeX
@article{Karpf2019,
   author = {Jiang, Y;Karpf, S and Jalali, B},
   title = {Time-stretch LiDAR as a spectrally scanned time-of-flight ranging camera},
   journal = {Nature Photonics},
   keywords={},
   ISSN = {1749-4893},
   URL = {https://www.researchgate.net/publication/337692338_Time-stretch_LiDAR_as_a_spectrally_scanned_time-of-flight_ranging_camera},
   year = {2019},
   type = {Journal Article}
}
 

C. Abbas,
Toward feedback temperature control for retinal laser treatment., .... SPIE, 2019.
File: 12.2527169
Bibtex: BibTeX
@book{Abbas-2019,
   author = {Abbas, H. S.;Kren, C.;Danicke, V.;Herzog, C. and Brinkmann, R.},
   title = {Toward feedback temperature control for retinal laser treatment},
   publisher = {SPIE},
   volume = {11079},
keywords = {Retina, Laser, Temperature, Optoacoustics, Photocoagulation, System identification, Automatic control},
   series = {European Conferences on Biomedical Optics},
   url = {https://doi.org/10.1117/12.2527169},
   year = {2019},
   type = {Book}
}
E Bliedtner,
Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty, TVST 8(6) , 2019.
DOI:10.1167/tvst.8.6.24
Bibtex: BibTeX
@article{Bliedtner2019,
   author = {Bliedtner, K;Seifert, E and Brinkmann, R},
   title = {Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty},
   journal = {TVST 8(6)},
  
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.8.6.24},
   year = {2019},
   type = {Journal Article}
}
H. Schulz-Hildebrandt, N. Meyer-Schell, M. Casper, M. Evers, and D. Manstein,
Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe, in Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II , 2019. pp. 1--3.
DOI:10.1117/12.2527087
ISBN:9781510628397
Bibtex: BibTeX
@inproceedings{Schulz-Hildebrandt2019,
author = {Schulz-Hildebrandt, Hinnerk and Meyer-Schell, Naja and Casper, Malte and Evers, Michael and Birngruber, Reginald and Manstein, Dieter and H{\"{u}}ttmann, Gereon},
booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II},
doi = {10.1117/12.2527087},
isbn = {9781510628397},
number = {110730L},
pages = {1--3},
title = {{Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe}},
keywords = {OCT, Endoskope},
year = { 2019}
}
T. Kohlfaerber, D. Shujun, R. Rahmanzadeh, T. Jüngst, J. Groll, H. Schulz-Hildebrandt, and G. Hüttmann,
Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT, Transactions on Additive Manufacturing Meets Medicine 1(1) , 2019.
DOI:10.18416/AMMM.2019.1909S03P19
Bibtex: BibTeX
@article{Kohlfärber2019,
   author = {Kohlfaerber, T;Ding, S;Rahmanzadeh, R;Jüngst, T;Groll, J;Schulz-Hildebrandt, H and Hüttmann, G},
   title = {Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT},
   journal = {Transactions on Additive Manufacturing Meets Medicine 1(1)},
   
   DOI = {10.18416/AMMM.2019.1909S03P19},
   year = {2019},
   type = {Journal Article}
}
R Freidank, and N. Linz,
Correction of hyperopia by intrastromal cutting and liquid filler injection, J Biomed Opt , no. 5%J Journal of Biomedical Optics, pp. 1-7, 7, 2019.
File: 1.JBO.24.5.058001
Bibtex: BibTeX
@article{Freidank2019,
   author = {Freidank, S;Vogel, A;Anderson, R. R.;Birngruber, R and Linz, N},
   title = {Correction of hyperopia by intrastromal cutting and liquid filler injection},
   journal = {J Biomed Opt},
  
   number = {5%J Journal of Biomedical Optics},
   pages = {1-7, 7},
   
   url = {https://doi.org/10.1117/1.JBO.24.5.058001},
   year = {2019},
   type = {Journal Article}
}
P Münter, and G H\"{u}ttmann,
4D microscopic optical coherence tomography imaging of ex vivo mucus transport, in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III , 2019. pp. 1--5.
ISBN:9781510628496
File: 12.2527138.full
Bibtex: BibTeX
@inproceedings{Muenter2019,
title = {4D microscopic optical coherence tomography imaging of ex vivo mucus transport},
author = { M\"{u}nter, M; Schulz-Hildebrandt, H; Pieper, M; K\"{o}nig, P and  H\"{u}ttmann, G},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527138/4D-microscopic-optical-coherence-tomography-imaging-of-ex-vivo-mucus/10.1117/12.2527138.full},

isbn = {9781510628496},
year = {2019},
date = {2019-01-01},
booktitle = {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III},
volume = {11078},
number = {11},
pages = {1--5},
keywords = {OCM},
pubstate = {published},
tppubtype = {inproceedings}
}
H Ahrens, and G H\"{u}ttmann,
An endomicroscopic OCT for clinical trials in the field of ENT (Invited), in Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II , 2019. pp. 1--4.
ISBN:9781510628397
File: 12.2527099.full
Bibtex: BibTeX
@inproceedings{Ahrens2019,
title = {An endomicroscopic OCT for clinical trials in the field of ENT (Invited)},
author = { Ahrens, M; Idel, C; Chaker, A; Wollenberg, B; K\"{o}nig, P; Schulz-Hildebrandt, H and H\"{u}ttmann, G},
url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11073/2527099/An-endomicroscopic-OCT-for-clinical-trials-in-the-field-of/10.1117/12.2527099.full},

isbn = {9781510628397},
year = {2019},
date = {2019-01-01},
booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II},
number = {110730U},
pages = {1--4},
keywords = {Endoskope, meos, OCM},
pubstate = {published},
tppubtype = {inproceedings}
}
M. Rudolf, C. Curcio, U. Schlötzer-Schrehardt, A. Mohi Sefat, A. Tura, M. Brinkmann, S. Grisanti, Y. Miura, and M. Ranjbar,
Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates, Invest Ophthalmol Vis Sci , pp. 461-472, 2019.
DOI:10.1167/iovs.18-25786
File: 30707219
Bibtex: BibTeX
@article{Miura2019-2,
   author = {Rudolf, M; Curcio, C A; Schlözer-Schrehardt, U; Sefat, A M M; Tura, A; Aherrahrou, Z; Brinkmann, M; Grisanti, S;  Miura, Y and Ranjbar, M},
   title = {Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates},
   journal = {Invest Ophthalmol Vis Sci},
   pages = {461-472},  
   url = {https://www.ncbi.nlm.nih.gov/pubmed/30707219},
   year = {2019},
   type = {Journal Article}
}
D. Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Optics letters , vol. 44(5), pp. 1315-1318, 2019.
DOI:https://doi.org/10.1364/OL.44001315
File: OL.44001315
Bibtex: BibTeX
@article{Spahr2019,
   author = {Spahr, H;Pfäffle, C;Huettmann, G and Hillmann, D},
   title = {Artifacts in speckle tracking and multi-aperture
Doppler OCT imaging of lateral motion},
   journal = {Optics letters},
   volume = {44(5)},
   pages = {1315-1318},
   DOI = {https://doi.org/10.1364/OL.44001315},
   url = {https://doi.org/10.1364/OL.44001315},
   year = {(2019)},
   type = {Journal Article}
}
C. Pfäffle, and D. Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt Lett , pp. 1315-1318, 2019.
File: OL.44.001315
Bibtex: BibTeX
@article{Spahr2019,
   author = {Spahr, H; Pfäffle, C; Huettmann, G and Hillmann, D},
   title = { Artifacts in speckle tracking and multi-aperture
Doppler OCT imaging of lateral motion},
   journal = { Opt Lett},
   pages = {1315-1318},
URL = {https://doi.org/10.1364/OL.44.001315},
   year = {2019},
   type = {Journal Article}
}
M. Casper, J. Glahn, M. Evers, G. Kositratna, G. H\"{u}ttmann, and D. Manstein,
Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography, Lasers in Surgery and Medicine , 2019.
DOI:10.1002/lsm.23188
Bibtex: BibTeX
@article{Casper2019b,
title = {Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography},
author = {Casper, M. J. and Glahn, J. and Evers, M. and Schulz-Hildebrandt, H. and Kositratna, G. and Birngruber, R. and H\"{u}ttmann, G. and Manstein, D.},
doi = {10.1002/lsm.23188},
year = {2019},
date = {2019-11-22},
journal = {Lasers in Surgery and Medicine},
abstract = {Background/Objectives Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining a more accurate anatomic representation of the surface capillary network in human skin using OCTA, along with proposing a new parameter, the Relative Capillary Capacity (RCC), a quantifiable proxy for assessing capillary dilation potential and permeability. Methods OCTA images were captured at baseline and after compression of the skin. Baseline images display ambient capillary perfusion, while images taken upon capillary refill display the network of existing capillaries at full capacity. An optimization-based automated vessel segmentation method was used to automatically analyze and compare OCTA image sequences obtained from two volunteers. RCC was then compared with visual impressions of capillary viability. Results Our OCTA imaging sequence provides a method for mapping cutaneous capillary networks independent of ambient perfusion. Differences between baseline and refill images clearly demonstrate the shortcomings of standard OCTA imaging and produce the RCC biometric as a quantifiable proxy for assessing capillary dilation potential and permeability. Conclusion Future dermatological OCTA diagnostic studies should implement the Capillary Refill Methods over standard imaging techniques and further explore the relevance of RCC to differential diagnosis and dermatopathology. 
\textbf{Lasers Surg. Med. © The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.}},
keywords = {mOCT},
pubstate = {published},
tppubtype = {article}
}
Y. Miura, B. Lewke, A. Hutfilz, and R. Brinkmann,
Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress, Nippon Ganka Gakkai Zasshi , pp. 105-114, 2019.
File: Disp
Bibtex: BibTeX
@article{Miura2019/3,
   
   author = {Miura, Y;Lewke, B;Hutfilz, A and Brinkmann, R},
   title = {Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress},
   journal = {Nippon Ganka Gakkai Zasshi },
  
   pages = {105-114},
   url = {http://journal.nichigan.or.jp/Disp?style=abst&vol=123&year=2019&mag=0&number=2&start=105},
   year = {2019},
   type = {Journal Article}
}

K. Hirayama, M. Yamamoto, T. Kohno, D. Theisen-Kunde, R. Brinkmann, Y. Miura, and S. Honda,
Change in the Thickness of Retinal Layers after Selective Retina Therapy (SRT) in Patients with Central Serous Chorioretinopathy, Osaka City Med. , vol. 65, pp. 55-63, 2019.
File: G0000438repository_00306096-65-1-55
Bibtex: BibTeX
@article{Miura2019,
   author = {Hirayama, K;Manabu Yamamoto, M; Takeya Kohno, T; Miura, Y; Brinkmann, R;  Shiraki,K;Theisen-Kunde, D; and Honda, S;},
   title = {Change in the Thickness of Retinal Layers after Selective Retina
Therapy (SRT) in Patients with Central Serous Chorioretinopathy},
   journal = {Osaka City Med.},
   volume = {65},
   pages = {55-63},
   url = {http://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-65-1-55},
   year = {2019},
   type = {Journal Article}
}
T Espinoza, and s Zwart,
Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy, Particle and Particle Systems Characterization , 2019.
File: 335364547_Characterization_of_Micro-_and_Nanoscale_LuPO4Pr3Nd3_with_Strong_UV-C_Emission_to_Reduce_X-Ray_Doses_in_Radiation_Therapy
Bibtex: BibTeX
@article{Rahmanzadeh-2019-2,
   author = {Espinoza, S;Müller, M;Jenneboer, H;Peulen, L;Bradley, T;Purschke, M;Haase, M;Rahmanzadeh, R;Jüstel, T and Zwart, s},
   title = {Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy},
   journal = {Particle and Particle Systems Characterization},
   URL = {https://www.researchgate.net/publication/335364547_Characterization_of_Micro-_and_Nanoscale_LuPO4Pr3Nd3_with_Strong_UV-C_Emission_to_Reduce_X-Ray_Doses_in_Radiation_Therapy},
   year = {2019},
   type = {Journal Article}
}
C Wang, and Z Zhang,
Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in Melanoma, ACS Applied Materials & Interfaces , 2019.
DOI:10.1021/acsami.9b09560
Bibtex: BibTeX
@article{Rahmanzadeh2019,
   author = {Wang, S;Liu, H;Xin, J;Rahmanzadeh, R;Wang, J;Yao, C and Zhang, Z},
   title = {Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in Melanoma},
   journal = {ACS Applied Materials & Interfaces},
   ISSN = {1944-8244},
   DOI = {10.1021/acsami.9b09560},  
   year = {2019},
   type = {Journal Article}
}
M. Schmidt, T. Pfeiffer, C. Grill, R. Huber, and C. Jirauschek,
Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 2019. pp. 1--1.
DOI:10.1109/CLEOE-EQEC.2019.8872381
Bibtex: BibTeX
@inproceedings{schmidt2019coexistence,
  title={Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers},
  author={Schmidt, M; Pfeiffer, T; Grill, C; Huber, R and Jirauschek, C},
  booktitle={2019 Conference on Lasers and Electro-Optics Europe \& European Quantum Electronics Conference (CLEO/Europe-EQEC)},
  pages={1--1},
  year={2019},
  organization={IEEE},
keywords= { AG-Huber_FDML},
url={  https://ieeexplore.ieee.org/document/8872381}

}
M. Ourak, J. Smits, L. Esteveny, G. Borghesan, A. Gijbels, L. Schoevaerdts, Y. Douven, J. Scholtes, E. Lankenau, G. H{"u}ttmann, M. Kozlovszky, G. Kronreif, K. Willekens, P. Stalmans, K. Faridpooya, M. Cereda, A. Giani, G. Staurenghi, D. Reynaerts, and E. Vander Poorten,
Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation, International Journal of Computer Assisted Radiology and Surgery , vol. 14, no. 2, pp. 301--309, 2019.
DOI:10.1007/s11548-018-1829-0
File: s11548-018-1829-0
Bibtex: BibTeX
@Article{Ourak2019,
author="Ourak, M.
and Smits, J.
and Esteveny, L.
and Borghesan, G.
and Gijbels, A.
and Schoevaerdts, L.
and Douven, Y.
and Scholtes, J.
and Lankenau, E.
and Eixmann, T.
and Schulz-Hildebrandt, H.
and H{\"u}ttmann, G.
and Kozlovszky, M.
and Kronreif, G.
and Willekens, K.
and Stalmans, P.
and Faridpooya, K.
and Cereda, M.
and Giani, A.
and Staurenghi, G.
and Reynaerts, D.
and Vander Poorten, E. B.",
title="Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation",
journal="International Journal of Computer Assisted Radiology and Surgery",
year="2019",
month="Feb",
day="01",
volume="14",
number="2",
pages="301--309",
abstract="Retinal vein cannulation is an experimental procedure during which a clot-dissolving drug is injected into an obstructed retinal vein. However, due to the fragility and minute size of retinal veins, such procedure is considered too risky to perform manually. With the aid of surgical robots, key limiting factors such as: unwanted eye rotations, hand tremor and instrument immobilization can be tackled. However, local instrument anatomy distance and force estimation remain unresolved issues. A reliable, real-time local interaction estimation between instrument tip and the retina could be a solution. This paper reports on the development of a combined force and distance sensing cannulation needle, and its experimental validation during in vivo animal trials.",
issn="1861-6429",
doi="10.1007/s11548-018-1829-0",
url="https://doi.org/10.1007/s11548-018-1829-0",
citation_key = {Ourak2019}
}
D. Hillmann, C. Pfäffle, H. Spahr, S. Burhan, L. Kutzner, F. Hilge, and G. Hüttmann,
Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations, Opt Lett 44 (15) , pp. 3905-3908, 2019.
DOI:10.1364/OL.44.003905
File: 31368998
Bibtex: BibTeX
@article{Hillmann2019,
   author = {Hillmann, D.;Pfaffle, C.;Spahr, H.;Burhan, S.;Kutzner, L.;Hilge, F. and Hüttmann, G.},
   title = {Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations},
   journal = {Opt Lett 44 (15)},
 
   pages = {3905-3908},
   ISSN = {1539-4794 (Electronic)
0146-9592 (Linking)},
   DOI = {10.1364/OL.44.003905},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/31368998},
   year = {2019},
   type = {Journal Article}
}
D. Hillmann, C. Pfäffle, H. Spahr, H. Sudkamp, G. Franke, and G. Hüttmann,
In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 181-194.
ISBN:978-3-030-16638-0
File: 978-3-030-16638-0_8
Bibtex: BibTeX
@inbook{Hillmann2019,
   author = {Hillmann, Dierck;Pfäffle, Clara;Spahr, Hendrik;Sudkamp, Helge;Franke, Gesa and Hüttmann, Gereon},
   title = {In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells},
   booktitle = {High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics},
   editor = {Bille, Josef F.},
   publisher = {Springer International Publishing},
   address = {Cham},
   pages = {181-194},
   ISBN = {978-3-030-16638-0},
   
   url = {https://doi.org/10.1007/978-3-030-16638-0_8},
   year = {2019},
   type = {Book Section}
}
E Bliedtner,
Dosimetry for microsecond selective laser trabeculoplasty, in Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX , 2019.
DOI:10.1117/12.2526987
Bibtex: BibTeX
@inproceedings{Bliedtner2019,
   author = {Bliedtner,K; Seifert, E and Brinkmann,R},
   title = {Dosimetry for microsecond selective laser trabeculoplasty},
   volume = {11079},
   DOI = {10.1117/12.2526987},
   year = {2019},
keywords = {Ophthalmology, ophthalmic optics and devices, selective laser trabeculoplasty, micro bubble detection},
booktitle =    {Proc. SPIE 11079, Medical Laser Applications
and Laser-Tissue Interactions IX},
   type = {Conference proceedings}
}
S. Karpf, and B Jalali,
Frequency-doubled FDML-MOPA laser in the visible, Opt Lett 44(24) , pp. 5913-5916, 2019.
DOI:10.1364/OL.44.005913
Bibtex: BibTeX
@article{karpf2019-2,
   author = {Karpf, S and Jalali, B},
   title = {Frequency-doubled FDML-MOPA laser in the visible},
   journal = {Opt Lett 44(24)},
   keywords = {},
   pages = {5913-5916},
   DOI = {10.1364/OL.44.005913},
   
   year = {2019},
   type = {Journal Article}
}
G Burchard, and J Roider,
High-Tech-Ophthalmologie zu Hause: Das Home-Care-OCT für AMD Patienten, Spitzenforschung in der Ophthalmologie- , pp. 30-32, 2019.
File:
Bibtex: BibTeX
@article{von-der-Burchardt2019,
   author = {von der Burchard, C;Sudkamp, H;Tode, J;Ehlken, C;Moltmann, M;Münst, M;Theisen-Kunde, D;Koch, P;Hüttman, G and Roider, J},
   title = {High-Tech-Ophthalmologie zu Hause: Das Home-Care-OCT für AMD Patienten},
   journal = {Spitzenforschung in der Ophthalmologie- },
   pages = {30-32},
   ISSN = {1861-4620},
   url = {https://www.dog.org/?cat=276},
   year = {2019},
   type = {Journal Article}
}
R Strenge,
Ex vivo and in vivo imaging of human brain tissue with different OCT systems, in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110781C , 2019.
DOI:10.1117/12.2526932
File: 12.2526932.short
Bibtex: BibTeX
@inproceedings{Strenge2019,
Title = {Ex vivo and in vivo imaging of human brain tissue with different OCT systems},
author = {Strenge, P.; Lange, B; Grill, C; Draxinger, W; Dannicke, V; Theisen-Kunde, D; Bonsanto, M; Huber, R and Brinkmann, R},
abstract = {Optical coherence tomography (OCT) is a non-invasive imaging technique which is currently investigated for intraoperative detection of residual tumor during resection of human gliomas. Three different OCT systems were used for imaging of human glioblastoma in vivo (830nm spectral domain (SD) OCT integrated into a surgical microscope) and ex vivo (940nm SD-OCT and 1310nm swept-source MHz-OCT using a Fourier domain mode locked (FDML) laser). Before clinical data acquisition, the systems were characterized using a three-dimensional point-spread function phantom. To distinguish tumor from healthy brain tissue later on, attenuation coefficients of each pixel in OCT depth profiles are calculated. First examples from a clinical study show that the pixel-resolved calculation of the attenuation coefficient provides a good image contrast and confirm that white matter shows a higher signal and more homogeneous signal structure than tumorous tissue.},
keywords = {Optical coherence tomography, OCT, FDML laser, MHz-OCT, glioblastoma, intraoperative imaging, brain
imaging},
   DOI= {10.1117/12.2526932},
   year = {2019},
   type = {Conference Paper}
}
G Hillmann,
In Vivo FF-SS-OCT Optical Imaging 8 of Physiological Responses to Photostimulation of Human Photoreceptor Cells, in High Resolution Imaging in Microscopy and Ophthalmology , Bille, Josef F., Eds. Cham, Switzerland: Springer Nature, 2019.
DOI:10.1007/978-3-030-16638-0
ISBN:978-3-030-16638-0 (online) 978-3-030-16637-3 (print)
File: 10.1007%2F978-3-030-16638-0_8.pdf
Bibtex: BibTeX
@inbook{Hillmann2019,
   author = {Hillmann, D;Pfäffle, C;Spahr, H;Sudkamp, H;Franke, G and Hüttmann, G},
   title = {In Vivo FF-SS-OCT Optical Imaging 8 of Physiological Responses to Photostimulation of Human Photoreceptor Cells},
   booktitle = {High Resolution Imaging in Microscopy and Ophthalmology},
   editor = {Bille, Josef F.},
   publisher = {Springer Nature},
   address = {Cham, Switzerland},

   ISBN = {978-3-030-16638-0 (online)
978-3-030-16637-3 (print)},
   DOI = {10.1007/978-3-030-16638-0},
   url = {https://link.springer.com/content/pdf/10.1007%2F978-3-030-16638-0_8.pdf},
   year = {2019},
   type = {Book Section}
}
T. Fischer, A. Klinger, D. Smolinski, R. Orzekowsky-Schroeder, F. Nitzsche, A. Vogel, G. Hüttmann, and A. Gebert,
High-resolution imaging of the living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , 2019.
Bibtex: BibTeX
@article{Vogel-2019-1,
   author = {Fischer, T;Klinger, A;Smolinski, D von;Orzekowsky-Schroeder, R;Nitzsche, F;Vogel, A;Hüttmann, G and Gebert, A},
   title = {High-resolution imaging of the living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures},
   journal = {Cell and Tissue Research},
   ISSN = {0302-766X (Print) 
1432-0878 (Online)},
   year = {2019},
   type = {Journal Article}
}
N. Detrez, Y. Miura, E. Seifert, D. Theisen-Kunde, and R. Brinkmann,
Heating and optoacoustic temperature determination of cell cultures, in Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX , SPIE, 2019.
File: 12.2527024
Bibtex: BibTeX
@inproceedings{Detrez2019,
   author = {Detrez, N;Miura, Y;Seifert, E;Theisen-Kunde, D and Brinkmann, R},
   title = {Heating and optoacoustic temperature determination of cell cultures},
   publisher = {SPIE},
   volume = {11079},
   series = {European Conferences on Biomedical Optics},
booktitle =    {Proc. SPIE 11079, Medical Laser Applications
and Laser-Tissue Interactions IX},
   url = {https://doi.org/10.1117/12.2527024},
keywords = {Laser, Noninvasive thermometry, hyperthermia, temperature measurement, photoacoustics}, optoacoustics,
   year = {2019},
   type = {Conference Proceeding}
}
R. Haak, M. Ahrens, H. Schneider, M. Strumpski, C. Rueger, M. Haefer, D. Theisen-Kunde, and H. Schulz-Hildebrandt,
Handheld OCT probe for intraoral diagnosis on teeth, in Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II , 2019. pp. 1--4.
DOI:10.1117/12.2527185
ISBN:9781510628397
File: 12.2527185.full
Bibtex: BibTeX
@inproceedings{Haak2019,
author = {Haak, Rainer and Ahrens, Martin and Schneider, Hartmut and Strumpski, Michaela and Rueger, Claudia and Haefer, Matthias and H{\"{u}}ttmann, Gereon and Theisen-Kunde, Dirk and Schulz-Hildebrandt, Hinnerk},
booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II},
doi = {10.1117/12.2527185},
isbn = {9781510628397},
number = {110730W},
pages = {1--4},
title = {{Handheld OCT probe for intraoral diagnosis on teeth}},
keywords = {OCT,Endoskope},
year = {2019},
}
S. Karpf, and B Jalali,
Fourier-domain mode-locked laser combined with a master-oscillator power amplifier architecture, J Opt Lett , pp. 1952-1955, 2019.
File: OL.44.001952
Bibtex: BibTeX
@article{Karpf2019,
   author = {Karpf, S and Jalali, B },
   title = {Fourier-domain mode-locked laser combined with a master-oscillator power amplifier architecture},
   journal = {J Opt Lett},
   URL = {https://doi.org/10.1364/OL.44.001952},
   pages = {1952-1955},
   ISSN = {1539-4794},
   year = {2019},
 keywords = {},
   type = {Journal Article}
}
Y. Miura, P. Bernstein, C. Dysli, L. Sauer, and M. Zinkernagel,
Fluorophores in the Eye, in Fluorescence Lifetime Imaging Ophthalmoscopy , Zinkernagel, Martin and Dysli, Chantal, Eds. Cham: Springer International Publishing, 2019, pp. 35-48.
DOI:https://link.springer.com/chapter/10.1007/978-3-030-22878-1_7
ISBN:978-3-030-22878-1
File: 978-3-030-22878-1_7
Bibtex: BibTeX
@inbook{Miura2019,
   author = {Miura, Y;Bernstein, P S;Dysli, C;Sauer, L and Zinkernagel, M},
   title = {Fluorophores in the Eye},
   booktitle = {Fluorescence Lifetime Imaging Ophthalmoscopy},
   editor = {Zinkernagel, Martin and Dysli, Chantal},
   publisher = {Springer International Publishing},
   address = {Cham},
   pages = {35-48},
   ISBN = {978-3-030-22878-1},
Keywords = {Retinoid cycle Lipofuscin Macular pigment Collagen/elastin Redox coenzyme Melanin Lipid peroxidation endproducts Advanced glycation endproducts (AGE) },
  
   url = {https://doi.org/10.1007/978-3-030-22878-1_7},
   year = {2019},
   type = {Book Section}
}
A. Hutfilz, S. Sonntag, B. Lewke, D. Theisen-Kunde, S. Grisanti, R. Brinkmann, and Y. Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy of the Retinal Pigment Epithelium During Wound Healing After Laser Irradiation, Translational Vision Science & Technology , vol. 8(5), 2019.
DOI:10.1167/tvst.8.5.12
Bibtex: BibTeX
@article{Hutfilz2019,
   author = {Hutfilz, A;Sonntag, S;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y},
   title = {Fluorescence Lifetime Imaging Ophthalmoscopy of the Retinal Pigment Epithelium During Wound Healing After Laser Irradiation},
   journal = {Translational Vision Science & Technology},
   volume = {8(5)},
 
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.8.5.12},
   year = {2019},
   type = {Journal Article}
}
G. Jäckle, and T Pätz,
Fiber optical shape sensing of flexible instruments for endovascular navigation, International Journal of Computer Assisted Radiology and Surgery , 2019.
File: s11548-019-02059-0
Bibtex: BibTeX
@article{Jäckle2019,
abstract = {Endovascular aortic repair procedures are currently conducted with 2D fluoroscopy imaging. Tracking systems based on fiber Bragg gratings are an emerging technology for the navigation of minimally invasive instruments which can reduce the X-ray exposure and the used contrast agent. Shape sensing of flexible structures is challenging and includes many calculations steps which are prone to different errors. To reduce this errors, we present an optimized shape sensing model.},
author = {J{\"{a}}ckle, S; Eixmann, T; Schulz-Hildebrandt, H; H{\"{u}}ttmann, Gereon and P{\"{a}}tz, T},

file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Computer Assisted Radiology and Surgery/J{\"{a}}ckle et al.{\_}2019{\_}Fiber optical shape sensing of flexible instruments for endovascular navigation.pdf:pdf},
issn = {1861-6429},
journal = {International Journal of Computer Assisted Radiology and Surgery},
month = {sep},
year = {2019},
title = {{Fiber optical shape sensing of flexible instruments for endovascular navigation}},
url = {https://doi.org/10.1007/s11548-019-02059-0},
keywords = {Endoskope, meos},

}
J. Lange,
Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence, Lasers in Surgery and Medicine , 2019.
File: lsm.23154
Bibtex: BibTeX
@article{Lange 2019,
   author = {Lange, B;Cordes, J. and Brinkmann, R},
   title = {Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence},
   journal = {Lasers in Surgery and Medicine},
   ISSN = {0196-8092},   
   url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/lsm.23154},
   year = {2019},
   type = {Journal Article}
}
J. Lange,
Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence, Lasers in Surgery and Medicine , 2019.
DOI:10.1002/lsm.23154
File: lsm.23154
Bibtex: BibTeX
@article{Lange2019,
   author = {Lange, B;Cordes, J. and Brinkmann, R},
   title = {Exploiting the aiming beam to increase the safety of laser lithotripsy: Experimental evaluation of light reflection and fluorescence},
   journal = {Lasers in Surgery and Medicine},
   
   ISSN = {0196-8092},
   DOI = {10.1002/lsm.23154},
   
   year = {2019},
   type = {Journal Article}
}
C Hutfilz,
Ex vivo investigation of different μs laser pulse durations for selective retina therapy., .... SPIE, 2019.
File: 12.2526948
Bibtex: BibTeX
@book{Hutfilz-2019,
   author = {Hutfilz, A;Burri, C;Theisen-Kunde, D;Meier, C and Brinkmann, R},
   title = {Ex vivo investigation of different μs laser pulse durations for selective retina therapy},
   publisher = {SPIE},
   volume = {11079},
Keywords = {selective retina therapy, SRT, retinal pigment epithelium, eye model, ED-values, intensity modulation factor, IMF},
   series = {European Conferences on Biomedical Optics},
   url = {https://doi.org/10.1117/12.2526948},
   year = {2019},
   type = {Book}
}

2018

J. Maertz, J. Kolb, T. Klein, K. Mohler, M. Eibl, W. Wieser, R. Huber, S. Priglinger, and A. Wolf,
Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm, Graefes Arch Clin Exp Ophthalmol , vol. 256, no. 2, pp. 289-298, Dec. 2018.
DOI:10.1007/s00417-017-3857-9
Bibtex: BibTeX
@article{Maertz2018,
   author = {Maertz, J; Kolb, J P; Klein, T; Mohler, K J; Eibl, M; Wieser, W; Huber, R; Priglinger, S and Wolf, A},
   title = {Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   number = {2},
   pages = {289-298},
   DOI = {10.1007/s00417-017-3857-9},
   url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032262413&doi=10.1007%2fs00417-017-3857-9&partnerID=40&md5=a46c315f12cf5e633ea0f7e644116eb3},
   year = {2018},
   Keywords= {En face imaging, Optical coherence tomography, Swept-source OCT, Megahertz OCT, 3D rendering, Optic disc, Optic disc pit, Optic disc pit maculopathy, AG-Huber_OCT},
   type = {Journal Article}
}
E. Seifert, J. Tode, A. Pielen, D. Theisen-Kunde, C. Framme, J. Roider, Y. Miura, R. Birngruber, and R. Brinkmann,
Selective retina therapy: toward an optically controlled automatic dosing, J Biomed Opt , pp. 1-12, Nov. 2018.
DOI:10.1117/1.JBO.23.11.115002
Bibtex: BibTeX
@article{seifert2018,
   author = {Seifert, E; Tode, J; Pielen, A; Theisen-Kunde, D; Framme, C; Roider, J; Miura, Y; Birngruber, R and Brinkmann, R},
   title = {Selective retina therapy: toward an optically controlled automatic dosing},
   journal = {J Biomed Opt},
   
   pages = {1-12},
   ISSN = {1560-2281 (Electronic)
1083-3668 (Linking)},
   DOI = {10.1117/1.JBO.23.11.115002},   
keywords = {algorithm, lasers in medicine, ophthalmology, retinal pigment epithelium, selective retina therapy, selectivity},
   year = {2018},
   type = {Journal Article}
}
M. Eibl, D. Weng, H. Hakert, J. Kolb, T. Pfeiffer, J. Hundt, R. Huber, and S. Karpf,
Wavelength agile multi-photon microscopy with a fiber amplified diode laser, Biomedical Optics Express , vol. 9, no. 12, pp. 6273-6282, Nov. 2018. The Optical Society.
DOI:10.1364/BOE.9.006273
Bibtex: BibTeX
@article{Eibl2018,
  doi = {10.1364/boe.9.006273},
  url = {https://doi.org/10.1364/boe.9.006273},
  year = {2018},
  month = nov,
  publisher = {The Optical Society},
  volume = {9},
  number = {12},
  pages = {6273},
  author = {Matthias Eibl and Daniel Weng and Hubertus Hakert and Jan Philip Kolb and Tom Pfeiffer and Jennifer E. Hundt and Robert Huber and Sebastian Karpf},
  title = {Wavelength agile multi-photon microscopy with a fiber amplified diode laser},
  journal = {Biomedical Optics Express}
}
H. Schulz-Hildebrandt, T. Pfeiffer, T. Eixmann, S. Lohmann, M. Ahrens, J. Rehra, W. Draxinger, P. König, R. Huber, and G. Hüttmann,
High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography, Opt. Lett. , vol. 43, no. 18, pp. 4386-4389, 09 2018. Optica Publishing Group.
DOI:10.1364/OL.43.004386
Bibtex: BibTeX
@article{Schulz-Hildebrandt:18,
author = {Hinnerk Schulz-Hildebrandt and Tom Pfeiffer and Tim Eixmann and Sabrina Lohmann and Martin Ahrens and Joshua Rehra and Wolfgang Draxinger and Peter K\"{o}nig and Robert Huber and Gereon H\"{u}ttmann},
journal = {Opt. Lett.},
keywords = {Fiber optics imaging; Endoscopic imaging; Medical and biological imaging; Optical coherence tomography; Fourier domain mode locking; Image quality; Optical coherence tomography; Single mode fibers; Step index fibers; Three dimensional imaging},
number = {18},
pages = {4386--4389},
publisher = {Optica Publishing Group},
title = {High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography},
volume = {43},
month = {Sep},
year = {2018},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-43-18-4386},
doi = {10.1364/OL.43.004386},
abstract = {We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 $\mu$m was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in spirals for scanning the sample, the beam quality remains constant over the entire field of view with a diameter of 0.8 mm. The scanning frequency was adjusted to 1.22 kHz for use with a 3.28 MHz Fourier domain mode locked OCT system. Densely sampled volumes have been imaged at a rate of 6 volumes per second.},
}
T. Pfeiffer, M. Petermann, W. Draxinger, C. Jirauschek, and R. Huber,
Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography, Biomed. Opt. Express , vol. 9, no. 9, pp. 4130-4148, 09 2018. Optica Publishing Group.
DOI:10.1364/BOE.9.004130
Bibtex: BibTeX
@article{Pfeiffer:18,
author = {Tom Pfeiffer and Markus Petermann and Wolfgang Draxinger and Christian Jirauschek and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Fiber optics imaging; Lasers, fiber; Optical coherence tomography; Laser stabilization ; Lasers, frequency modulated ; Analog to digital converters; Dark solitons; Image quality; Laser modes; Mode locking; Optical coherence tomography},
number = {9},
pages = {4130--4148},
publisher = {Optica Publishing Group},
title = {Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography},
volume = {9},
month = {Sep},
year = {2018},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-9-9-4130},
doi = {10.1364/BOE.9.004130},
abstract = {We investigate the origin of high frequency noise in Fourier domain mode locked (FDML) lasers and present an extremely well dispersion compensated setup which virtually eliminates intensity noise and dramatically improves coherence properties. We show optical coherence tomography (OCT) imaging at 3.2 MHz A-scan rate and demonstrate the positive impact of the described improvements on the image quality. Especially in highly scattering samples, at specular reflections and for strong signals at large depth, the noise in optical coherence tomography images is significantly reduced. We also describe a simple model that suggests a passive physical stabilizing mechanism that leads to an automatic compensation of remaining cavity dispersion in FDML lasers.},
}
H. Sudkamp, D. Hillmann, P. Koch, M. vom Endt, H. Spahr, M. Münst, C. Pfäffle, R. Birngruber, and G. Hüttmann,
Simple approach for aberration-corrected OCT imaging of the human retina, Opt Lett , vol. 43, no. 17, pp. 4224, 08 2018.
DOI:10.1364/ol.43.004224
Bibtex: BibTeX
@article{Sudkamp2018a,
   author = {Sudkamp, H; Hillmann, D; Koch, P;vom Endt, M; Spahr, H; Münst, M; Pfäffle, C; Birngruber, R and Hüttmann, G},
   title = {Simple approach for aberration-corrected OCT imaging of the human retina},
   journal = {Opt Lett},
   
   pages = {4224},
   ISSN = {0146-9592
1539-4794},
   DOI = {10.1364/ol.43.004224},
   year = {2018},
   type = {Journal Article},
   keyword = {Retome}
}
M. Schmidt, T. Pfeiffer, C. Grill, R. Huber, and C. Jirauschek,
Self-Stabilization Mechanism in Fourier Domain Mode-Locked (FDML) Lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2018. Optica Publishing Group.
DOI:10.1364/OSAC.389972
Bibtex: BibTeX
@article{Schmidt:20,
author = {Mark Schmidt and Tom Pfeiffer and Christin Grill and Robert Huber and Christian Jirauschek},
journal = {OSA Continuum},
keywords = {Doppler effect; Laser modes; Laser sources; Nonlinear effects; Stimulated Raman scattering; Vertical cavity surface emitting lasers},
number = {6},
pages = {1589--1607},
publisher = {Optica Publishing Group},
title = {Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers},
volume = {3},
month = {Jun},
year = {2020},
url = {https://opg.optica.org/osac/abstract.cfm?URI=osac-3-6-1589},
doi = {10.1364/OSAC.389972},
abstract = {Understanding the dynamics of Fourier domain mode-locked (FDML) lasers is crucial for determining physical coherence limits, and for finding new superior methods for experimental realization. In addition, the rich interplay of linear and nonlinear effects in a laser ring system is of great theoretical interest. Here we investigate the dynamics of a highly dispersion-compensated setup, where over a bandwidth of more than 100\&\#x2009;nm, a highly coherent output with nearly shot-noise-limited intensity fluctuations was experimentally demonstrated. This output is called the sweet-spot. We show by numerical simulation that a finite amount of residual dispersion in the fiber delay cavity of FDML lasers can be compensated by the group delay dispersion in the swept bandpass filter, such that the intensity trace exhibits no dips or high-frequency distortions, which are the main source of noise in the laser. In the same way, a small detuning from the ideal sweep filter frequency can be tolerated. Furthermore, we find that the filter\&\#x2019;s group delay dispersion improves the coherence properties of the laser, and acts as a self-stabilizing element in the cavity. Our theoretical model is validated against experimental data, showing that all relevant physical effects for the sweet-spot operating regime are included.},
}
J. Kolb, T. Pfeiffer, M. Eibl, H. Hakert, and R. Huber,
High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates, Biomed. Opt. Express , vol. 9, no. 1, pp. 120-130, 01 2018. Optica Publishing Group.
DOI:10.1364/BOE.9.000120
Bibtex: BibTeX
@article{Kolb:18,
author = {Jan Philip Kolb and Tom Pfeiffer and Matthias Eibl and Hubertus Hakert and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Medical optics instrumentation; Lasers, fiber; Medical and biological imaging; Ophthalmic optics and devices ; Optical coherence tomography; Adaptive optics; Image quality; In vivo imaging; Mode locking; Ophthalmic imaging; Three dimensional imaging},
number = {1},
pages = {120--130},
publisher = {Optica Publishing Group},
title = {High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates},
volume = {9},
month = {Jan},
year = {2018},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-9-1-120},
doi = {10.1364/BOE.9.000120},
abstract = {We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2\&\#x2219;\&\#x202F;417 kHz\&\#x202F; $=$ \&\#x202F;834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 \&\#x00B5;m axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 nm sweep range, as well as to existing spectral domain OCT data with 2.1 \&\#x00B5;m axial resolution from literature. We identify benefits of the higher resolution, for example the improved visualization of small blood vessels in the retina besides several others.},
}
C. Herzog, B. Schmarbeck, O. Thomsen, M. Siebert, and R. Brinkmann,
Temperature-controlled laser therapy of the retina via robust adaptive Ɦ∞-control., .... De Gruyter, 2018.
File: auto-2018-0066
Bibtex: BibTeX
   @book{Brinkmann2018/2,
   author = {Herzog, C;Thompson, O; Schmarbeck, B; Siebert, M and Brinkmann, R},
   title = {Temperature-controlled laser therapy of the retina via robust adaptive Ɦ∞-control},
   publisher = {De Gruyter},
   
   journal = {at-Automatisierungstechnik},
   pages = {1051-1063},   
   year = {2018},
   type = {Book},
  URL = {https://doi.org/10.1515/auto-2018-0066},
   
  
keywords = {Laser therapy; robust control; parameter estimation; photoacoustics; real-time temperature determination},
   abstract = {Recent studies demonstrate therapeutic benefits in retinal laser therapy even for non-visible effects of the irradiation. However, in practice, ophthalmologists often rely on the visual inspection of irradiation sites to manually set the laser power for subsequent ones. Since absorption properties vary strongly between sites, this procedure can lead to under- or over-treatment. To achieve safe automatic retinal laser therapy, this article proposes a robust control scheme based on photoacoustic feedback of the retinal temperature increase. The control scheme is further extended to adapt to real-time parameter estimates and associated bounds on the uncertainty of each irradiation site. Both approaches are successfully validated in ex vivo experiments on pigs’ eyes, achieving consistent irradiation durations of 55 ms despite the uncertainty in absorption properties.}
}