@inproceedings{10.1117/12.2670944,
author = {Nicolas Detrez and Sazgar Burhan and Paul Strenge and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis}},
volume = {12629},
booktitle = {Emerging Technologies for Cell and Tissue Characterization II},
editor = {Seemantini K. Nadkarni and Giuliano Scarcelli},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126290M},
keywords = {Optical Coherence Elastography, Air-Jet, Phase-sensitive OCT, Histology Structure Analysis, Color-Deconvolution, Structural Tensors, Brain tumor, Tissue Characterization},
year = {2023},
doi = {10.1117/12.2670944},
URL = {https://doi.org/10.1117/12.2670944}
}

@inproceedings{10.1117/12.2649835,
author = {Nicolas Detrez and Sazgar Burhan and Katharina Rewerts and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data}},
volume = {12381},
booktitle = {Optical Elastography and Tissue Biomechanics X},
editor = {Kirill V. Larin and Giuliano Scarcelli and Fr{\'e}d{\'e}rique Vanholsbeeck},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1238105},
keywords = {Optical Coherence Elastography, Air-Jet, Air-Puff, biomechanics, viscoelasticity, rheology, brain tissue, brain tumor},
year = {2023},
doi = {10.1117/12.2649835},
URL = {https://doi.org/10.1117/12.2649835}
}

@inproceedings{10.1117/12.2651127,
author = {A. Mart{\'i}nez Jim{\'e}nez and M. Spacek and M. Wacker and R. Huber and A. Bradu and A. Podoleanu},
title = {{MHz time stretch swept source using a commercial erbium-doped fiber amplifier}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1236706},
keywords = {swept source, time-stretch, optical coherence tomography, mode-locking},
year = {2023},
doi = {10.1117/12.2651127},
URL = {https://doi.org/10.1117/12.2651127}
}

@inproceedings{10.1117/12.2652847,
author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Madita G{\"o}b and Steffen Buschschl{\"u}ter and Christian Hagel and Matteo Mario Bonsanto M.D. and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Phase analysis strategies for MHz OCE in the large displacement regime}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {123670Q},
abstract = {In neurosurgical tumor operations on the central nervous system, intraoperative haptic information often assists for discrimination between healthy and diseased tissue. Thus, it can provide the neurosurgeon with additional intraoperative source of information during resection, next to the visual information by the light microscope, fluorescent dyes and neuronavigation. One approach to obtain elastic and viscoelastic tissue characteristics non-subjectively is phase-sensitive optical coherence elastography (OCE), which is based on the principle of optical coherence tomography (OCT). While phase-sensitive OCE offers significantly higher displacement sensitivity inside a sample than commonly used intensity-based correlation methods, it requires a reliable algorithm to recover the phase signal, which is mathematically restricted in the -π to π range. This problem of phase wrapping is especially critical for inter-frame phase analysis since the time intervals between two referenced voxels is long. Here, we demonstrate a one-dimensional unwrapping algorithm capable of removing up to 4π-ambiguities between two frames in the complex phase data obtained from a 3.2 MHz-OCT system. The high sampling rate allows us to resolve large sample displacements induced by a 200 ms air pulse and acquires pixel-precise detail information. The deformation behavior of the tissue can be monitored over the entire acquisition time, offering various subsequent mechanical analysis procedures. The reliability of the algorithm and imaging concept was initially evaluated using different brain tumor mimicking phantoms. Additionally, results from human ex vivo brain tumor samples are presented and correlated with histological findings supporting the robustness of the algorithm.},
keywords = {Optical Coherence Tomography, Megahertz OCT, Fourier Domain Mode Locking, Optical Coherence Elastography, Phase-sensitive OCT, Phase Unwrapping, Brain tumor, Biomechanics},
year = {2023},
doi = {10.1117/12.2652847},
URL = {https://doi.org/10.1117/12.2652847}
}

@article{RN5426,
   author = {Aşırım, Özüm Emre;Huber, Robert and Jirauschek, Christian},
   title = {Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers},
   journal = {Applied Physics B},
   volume = {128},
   number = {12},
   pages = {218},
   ISSN = {1432-0649},
   DOI = {10.1007/s00340-022-07933-5},
   url = {https://doi.org/10.1007/s00340-022-07933-5},
   year = {2022},
   type = {Journal Article}
}

@article{JACOBI2022S288,
title = {620 Screening an inhibitor library for new drug candidates to promote wound healing},
journal = {Journal of Investigative Dermatology},
volume = {142},
number = {12, Supplement },
pages = {S288},
year = {2022},
note = {ESDR 2022 Meeting Abstract Supplement},
issn = {0022-202X},
doi = {https://doi.org/10.1016/j.jid.2022.09.637},
url = {https://www.sciencedirect.com/science/article/pii/S0022202X22025714},
author = {C. Jacobi and M. Göb and R. Huber and R.J. Ludwig and J.E. Hundt}
}

Optical coherence elastography (OCE), a functional extension of optical coherence tomography (OCT), visualizes tissue strain to deduce the tissue’s biomechanical properties. In this study, we demonstrate intravascular OCE using a 1.1 mm motorized catheter and a 1.6 MHz Fourier domain mode-locked OCT system. We induced an intraluminal pressure change by varying the infusion rate from the proximal end of the catheter. We analysed the pixel-matched phase change between two different frames to yield the radial strain. Imaging experiments were carried out in a phantom and in human coronary arteries in vitro. At an imaging speed of 3019 frames/s, we were able to capture the dynamic strain. Stiff inclusions in the phantom and calcification in atherosclerotic plaques are associated with low strain values and can be distinguished from the surrounding soft material, which exhibits elevated strain. For the first time, circumferential intravascular OCE images are provided side by side with conventional OCT images, simultaneously mapping both the tissue structure and stiffness.

@article{RN5359,
   author = {Ha-Wissel, L.;Yasak, H.;Huber, R.;Zillikens, D.;Ludwig, R. J.;Thaçi, D. and Hundt, J. E.},
   title = {Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis},
   journal = {Front Med (Lausanne)},
   volume = {9},
   pages = {995883},
   ISSN = {2296-858X (Print)
2296-858x},
   DOI = {10.3389/fmed.2022.995883},
   year = {2022},
   type = {Journal Article}
}

@article{Strenge-2022,
   author = {Strenge, P.;Lange, B.;Grill,C.;Danicke,V.;Theisen-Kunde, D.;Hagel, C.;Spahr-Hess, S.;;Bonsanto, Matteo M.;Handels, H.; and Huber, R.;Brinkmann, R.},
   title = {Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology},
   journal = {Frontiers in Oncology},
Keywords = {AG-Huber_FDML, AG-Huber_OCT, brain, tumor, glioblastoma multiforme, OCT, neural network, attenuation (absorption)
coefficient, optical coherence tomography},
   DOI = {https://doi.org/10.3389/fonc.2022.896060},
   url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.896060/full},
   year = {2022},
   type = {Journal Article}
}

@article{Grill2022,
  doi = {10.1038/s42005-022-00960-w},
  year = {2022},
  publisher = {Springer Science and Business Media {LLC}},
  volume = {{5}},
  number = {{1}},
  author = {C. Grill, T. Bl\"{o}mker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber},
  title = {Towards phase-stabilized Fourier domain mode-locked frequency combs},
  journal = {{Communications Physics}},
keywords={AG-Huber_FDML, FDML, Fourier domain mode locking, phase, frequency comb, coherence, beating}
}

@article{Strenge2022,
   author = {Strenge, P;Lange, B;Grill, C;Draxinger, W;Danicke, V;Theisen-Kunde, D;Hagel, C;Spahr-Hess, S;Bonsanto, Matteo M.;Huber, R;Handels, H and Brinkmann, R},
   title = {Registration of histological brain images onto optical coherence tomography images based on shape information},
keywords = {brain, glioblastoma multiforme, shape, OCT, optical coherence tomography, AG-Huber_OCT,},
   journal = {Physics in Medicine & Biology},
   ISSN = {0031-9155},
   url = {http://iopscience.iop.org/article/10.1088/1361-6560/ac6d9d},
   year = {2022},
   type = {Journal Article}
}

@inproceedings{10.1117/12.2612171,
author = {Madita G{\"o}b and Sazgar Burhan and Simon Lotz and Robert Huber},
title = {{Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT}},
volume = {11948},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1194807},
abstract = {We demonstrate ultra-large field of view OCT scanning using standard optics, a X-Y-galvanometer scanner and a synchronously driven motorized XYZ-positioning stage. The integration of a movable stage into our self-built 3.3 MHz- OCT system allows acquiring coherent ultra-large area images, fully leveraging the high speed potential of our system. For fast OCT-angiography, one galvanometer axis scanner is driven in a repetitive sawtooth pattern, fully synchronized to the movement of the linear stage, to obtain multiple measurements at each position. This technique requires exact synchronization, precise repositioning, and uniform movements with low tolerances to ensure a minimum revisitation error. We analyze error and performance of our setup and demonstrate angiographic imaging.},
keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, FDML, Optical Coherence Angiography, OCTA, Medical optics and biotechnology, Medical imaging, Three-dimensional image acquisition, Scanners, Microscopy},
year = {2022},
doi = {10.1117/12.2612171},
URL = {https://doi.org/10.1117/12.2612171}
}

@inproceedings{10.1117/12.2608773,
author = {M. Klufts and S. Lotz and M. Bashir and S. Karpf and R. Huber},
title = {{Ultra-high-accuracy chromatic dispersion measurement in optical fibers}},
volume = {11997},
booktitle = {Optical Components and Materials XIX},
editor = {Shibin Jiang and Michel J. F. Digonnet},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {119970L},
abstract = {The chromatic dispersion in optical fibers is a key property for applications where a broadband light source is used and the timing of each individual wavelength is crucial. Counteracting the timing offset introduced by the fiber is a challenge in many applications especially in mode locked lasers. The dispersion parameters need to be measured with high precision. The length of the fiber, the temperature, and the used wavelength will highly impact the amount of dispersion and the accuracy of the measurement. We developed an ultra-high-accuracy dispersion measurement setup at 1080 ± 50 nm considering all the parameters that may influence the measurement. It is based on a home-built wavelength tunable laser where the output is modulated by an electro-optical modulator connected to a 24 GSamples/s arbitrary waveform generator to a complex pattern consisting of pulses and a 4 GHz sine wave. After passing through the fiber the signal is measured with an 80 GSamples/s real time oscilloscope. The fiber’s temperature is controlled to allow for reproducible measurements over several days and we achieve timing measurement accuracies down to ~200 fs. We also present the performance of the setup at ~850 nm. We will discuss and quantify all effects which can negatively impact the system accuracy and we will report on more cost-effective options using lower performance equipment.},
keywords = {Dispersion measurement, Chromatic dispersion, fiber dispersion measurement, optical component characterization, tunable laser, FDML},
year = {2022},
doi = {10.1117/12.2608773},
URL = {https://doi.org/10.1117/12.2608773}
}

@article{Deen2022,
   author = {Deen, A D;Van Beusekom, H M. M.;Pfeiffer, T;Stam, M;Kleijn, D De;Wentzel, J;Huber, R;Van Der Steen, A F. W.;Soest, G Van and Wang, T},
   title = {Spectroscopic thermo-elastic optical coherence tomography for tissue characterization},
   journal = {BioOptExpr},
keywords = {AG-Huber, Endoscopic imaging, Image processing, Image quality, Imaging techniques, Optical imaging, Tissue characterization},
   volume = {13(3)},
   pages = {1430-1446},
   DOI = {10.1364/BOE.447911},
    year = {2022},
   type = {Journal Article}
}

@article{Gob:22,
author = {Madita G\"{o}b and Tom Pfeiffer and Wolfgang Draxinger and Simon Lotz and Jan Philip Kolb and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {High speed imaging; Image processing; Image quality; In vivo imaging; Range imaging; Vertical cavity surface emitting lasers},
number = {2},
pages = {713--727},
publisher = {Optica Publishing Group},
title = {Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence},
volume = {13},
month = {Feb},
year = {2022},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-13-2-713},
doi = {10.1364/BOE.448353},
abstract = {We present continuous three-dimensional spectral zooming in live 4D-OCT using a home-built FDML based OCT system with 3.28 MHz A-scan rate. Improved coherence characteristics of the FDML laser allow for imaging ranges up to 10 cm. For the axial spectral zoom feature, we switch between high resolution and long imaging range by adjusting the sweep range of our laser. We present a new imaging setup allowing for synchronized adjustments of the imaging range and lateral field of view during live OCT imaging. For this, a novel inline recalibration algorithm was implemented that enables numerical k-linearization of the raw OCT fringes for every frame instead of every volume. This is realized by acquiring recalibration data within the dead time of the raster scan at the turning points of the fast axis scanner. We demonstrate in vivo OCT images of fingers and hands at different resolution modes and show real three-dimensional zooming during live 4D-OCT. A three-dimensional spectral zooming feature for live 4D-OCT is expected to be a useful tool for a wide range of biomedical, scientific and research applications, especially in OCT guided surgery.},
}

@article{Yashin-2022,
   author = {Yashin, K;Bonsanto, M M;Achkasova, K;Zolotova, A;Wael, Al-M;Kiseleva, E;Moiseev, A;Medyanik, I;Kravets, L;Huber, R;Brinkmann, R and Gladkova, N},
   title = {OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives},
   journal = {Diagnostics},
   volume = {12},
   number = {2},
   pages = {335},
   ISSN = {2075-4418},
keywords = {AG-Huber; optical coherence tomography; brain imaging; neurosurgical guidance; brain tumor; minimally invasive theranostics; intraoperative imaging},
   url = {https://www.mdpi.com/2075-4418/12/2/335},
   year = {2022},
   type = {Journal Article}
}

@INPROCEEDINGS{9894816,
  author={Aşırım, Ö. E. and Huber, R. and Jirauschek, C.},
  booktitle={2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD)}, 
  title={Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers}, 
  year={2022},
  volume={},
  number={},
  pages={67-68},
  doi={10.1109/NUSOD54938.2022.9894816}}

@inproceedings{Strenge:21,
author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography},
pages = {EW1C.7},
publisher = {Optical Society of America},
title = {Comparison of two optical coherence tomography systems to identify human brain tumor},
year = {2021},
url = {https://doi.org/10.1117/12.2616044},
abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.},
}

@inproceedings{Gob:21,
author = {Madita G\"{o}b and Sazgar Burhan and Wolfgang Draxinger and Jan Philip Kolb and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT;Fourier domain mode locking; Image processing; Image quality; Optical coherence tomography; Temporal resolution; Three dimensional imaging},
pages = {EW3C.4},
publisher = {Optical Society of America},
title = {Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm$^2$/sec},
year = {2021},
url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-EW3C.4},
abstract = {We demonstrate a 3.3 MHz A-scan rate OCT for rapid scanning of large areas of human skin. The mosaicking performance and different OCT imaging modalities including intervolume speckle contrast are evaluated.},
}

@inproceedings{Detrez:21,
author = {N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlueter, M.M. Bonsanto, D. Theisen-Kunde and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT},
pages = {EW4A.10},
publisher = {Optical Society of America},
title = {Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography},
year = {2021},
url = {https://doi.org/10.1117/12.2615022},
abstract = {A precision air puff excitation system for MHz Optical Coherence Elastography in neurosurgery was developed. It enables non-contact soft-tissue excitation down to {\textmu}N, with direct, noncontact force determination via gas flow measurement.},
}

@inproceedings{Rewerts2021ECBO,
author = {K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlueter, M.M. Bonsanto, R. Huber and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT},
pages = {ETh3A.3},
publisher = {Optical Society of America},
title = {Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation},
year = {2021},
url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-ETh3A.3},
abstract = {Tumor discrimination from healthy tissue is often performed by haptically probing tissue elasticity. We demonstrate non-contact elastography using air-puff excitation and tissue indentation measurement by phase-sensitive OCT with a 3.2 MHz FDML-laser.},
}

@article{Hakert2021,
   author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber},
   title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1},
   journal = {Optics Letters},
   volume = {46(14)},
   number = {14},
   pages = {3456-3459},
keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering},
   DOI = {https://doi.org/10.1364/OL.424726},
   year = {2021},
   type = {Journal Article}
}

@article{PenateMedina2021,
   author = {Peñate Medina, T;Kolb, J P;Hüttmann, G;Huber, R;Peñate Medina, O;Ha, L;Ulloa, P;Larsen, N;Ferrari, A;Rafecas, M;Ellrichmann, M;Pravdivtseva, M S.;Anikeeva, M;Humbert, J;Both, M;Hundt, J E. and Hövener, J-B},
   title = {Imaging Inflammation - From Whole Body Imaging to Cellular Resolution},
   journal = {Frontiers in immunology},
keywords = {AG-Huber, MRI, PET, SPECT, optical imaging, Optical coherence tomography (OCT), precision medicine, Two-Photon microscopy (TPM), hyperpolarization},
   volume = {12},
   pages = {692222-692222},
   ISSN = {1664-3224},
   DOI = {10.3389/fimmu.2021.692222},
   url = {https://pubmed.ncbi.nlm.nih.gov/34248987
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264453/},
   year = {2021},
   type = {Journal Article}
}

@INPROCEEDINGS{9542126,
  author={Grill, Christin and Lotz, Simon and Blömker, Torben and Schmidt, Mark and Draxinger, Wolfgang and Kolb, Jan Philip and Jirauschek, Christian and Huber, Robert},
  booktitle={2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Superposition of two independent FDML lasers}, 
  year={2021},
  volume={},
  number={},
  pages={1-1},
  abstract={Fourier domain mode locking (FDML) is a laser operating regime, which was developed in 2005 [1] . The output of this laser is a train of optical wavelength sweeps, equivalent to extremely chirped pulses with an optical bandwidth of up to 25 THz and frequency tuning rates of >10 19 Hz/s. This laser type was developed for optical coherence tomography [2] , but found recently more and more applications like LiDAR [3] , Raman microscopy [4] or two-photon microscopy [5] . The laser’s coherence properties are relevant for a better understanding of the FDML laser itself and its applications. Because of the wide sweep range and high tuning rate, the laser linewidth cannot be measured with an RF spectrometer. Superposition with a narrowband continuous wave laser only yields phase information for small fractions of the sweep [6] . However, beat signal measurements between two independent FDML lasers with equal sweep range and direction can give information about the complete sweep.},
  keywords={},
  doi={10.1109/CLEO/Europe-EQEC52157.2021.9542126},
  ISSN={},
  month={June}
}

@inproceedings{Pfeiffer2021,
author = {T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill and R. Huber},
title = {{High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers}},
volume = {11630},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
abstract = {We demonstrate that the coherence roll-off and dynamic range of OCT systems using Fourier-domain mode-locked (FDML) lasers can be significantly improved by a fiber Fabry-Perot tunable filter (FFP-TF) with a finesse of more than 3000, a more than fivefold improvement over previous designs. In contrast to previous work, standard resampling using a pre-acquired signal (as in SD-OCT) with no k-clocking is sufficient for 20 nm and 100 nm sweep range, significantly reducing the system complexity. 3D-OCT imaging at 20 cm imaging range is demonstrated.},
keywords = {AG-Huber_FDML, AG-Huber_OCT, optical coherence tomography, FDML laser, swept source laser, high finesse, Fabry-Perot, MHz-OCT, OCT, tunable laser},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2583501}
}