@inproceedings{Detrez:25,
author = {Nicolas Detrez and Dirk Theisen-Kunde and Wolfgang Draxinger and Thies H\"{o}rcher and Veit Danicke and Sazgar Burhan and Jessica Kren and Matteo Mario Bonsanto and Robert Huber and Ralf Brinkmann},
booktitle = {European Conferences on Biomedical Optics 2025},
journal = {European Conferences on Biomedical Optics 2025},
keywords = {Coherence and statistical optics; Elastography; Modes; Optical coherence tomography; Phase; Phase measurement},
pages = {M3A.36},
publisher = {Optica Publishing Group},
title = {Co-Robot Supported Air-Jet Based Optical Coherence Elastography Towards In-Situ Brain Tumor Tissue Delineation},
year = {2025},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2025-M3A.36},
doi = {10.1364/ECBO.2025.M3A.36},
abstract = {Accurate tumor delineation in neurosurgery is challenging. We developed an in-situ optical coherence elastography system using air-jet excitation and phase based full-range OCT. The challenges in transitioning from ex vivo to in-situ application are presented.},
}

@article{Burhan:24,
author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Paul Strenge and Steffen Buschschl\"{u}ter and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {High speed imaging; Imaging systems; In vivo imaging; Magnetic resonance imaging; Phase noise; Phase shift},
number = {2},
pages = {1038--1058},
publisher = {Optica Publishing Group},
title = {Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue},
volume = {15},
month = {Feb},
year = {2024},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-15-2-1038},
doi = {10.1364/BOE.510020},
abstract = {During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2\&\#x2005;MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2\&\#x03C0; wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm\&\#x0027;s reliability. The tissue samples were subjected to a 200\&\#x2005;ms short air pulse. A correlation with histological findings confirmed the algorithm\&\#x0027;s dependability.},
}

@article{Singh:24,
author = {Awanish Pratap Singh and Madita G\"{o}b and Martin Ahrens and Tim Eixmann and Berenice Schulte and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Mark Ellrichmann and Robert Huber and Maik Rahlves},
journal = {Opt. Express},
keywords = {Biomedical imaging; Endoscopic imaging; Imaging systems; Optical coherence tomography; Real time imaging; Vertical cavity surface emitting lasers},
number = {4},
pages = {5809--5825},
publisher = {Optica Publishing Group},
title = {Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization},
volume = {32},
month = {Feb},
year = {2024},
url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-32-4-5809},
doi = {10.1364/OE.514636},
abstract = {Circumferential scanning in endoscopic imaging is crucial across various disciplines, and optical coherence tomography (OCT) is often the preferred choice due to its high-speed, high-resolution, and micron-scale imaging capabilities. Moreover, real-time and high-speed 3D endoscopy is a pivotal technology for medical screening and precise surgical guidance, among other applications. However, challenges such as image jitter and non-uniform rotational distortion (NURD) are persistent obstacles that hinder real-time visualization during high-speed OCT procedures. To address this issue, we developed an innovative, low-cost endoscope that employs a brushless DC motor for scanning, and a sensorless technique for triggering and synchronizing OCT imaging with the scanning motor. This sensorless approach uses the motor\&\#x2019;s electrical feedback (back electromotive force, BEMF) as a virtual Hall sensor to initiate OCT image acquisition and synchronize it with a Fourier Domain Mode-Locked (FDML)-based Megahertz OCT system. Notably, the implementation of BEMF-triggered OCT has led to a substantial reduction in image jitter and NURD (\<4 mrad), thereby opening up a new window for real-time visualization capabilities. This approach suggests potential benefits across various applications, aiming to provide a more accurate, deployable, and cost-effective solution. Subsequent studies can explore the adaptability of this system to specific clinical scenarios and its performance under practical endoscopic conditions.},
}

@article{RN5472,
   author = {Kren, Jessica;Skambath, Isabelle;Kuppler, Patrick;Buschschlüter, Steffen;Detrez, Nicolas;Burhan, Sazgar;Huber, Robert;Brinkmann, Ralf and Bonsanto, Matteo Mario},
   title = {Mechanical characteristics of glioblastoma and peritumoral tumor-free human brain tissue},
   journal = {Acta Neurochirurgica},
   volume = {166},
   number = {1},
   pages = {102},
   ISSN = {0942-0940},
   DOI = {10.1007/s00701-024-06009-x},
   url = {https://doi.org/10.1007/s00701-024-06009-x},
   year = {2024},
   type = {Journal Article}
}

@article{RN5474,
   author = {Schulte, Berenice;Göb, Madita;Singh, Awanish Pratap;Lotz, Simon;Draxinger, Wolfgang;Heimke, Marvin;pieper, Mario;Heinze, Tillmann;Wedel, Thilo;Rahlves, Maik;Huber, Robert and Ellrichmann, Mark},
   title = {High-resolution rectoscopy using MHz optical coherence tomography: a step towards real time 3D endoscopy},
   journal = {Scientific Reports},
   volume = {14},
   number = {1},
   pages = {4672},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-024-55338-5},
   url = {https://doi.org/10.1038/s41598-024-55338-5},
   year = {2024},
   type = {Journal Article}
}

@article{10.1093/ecco-jcc/jjae034,
    author = {Ellrichmann, Mark and Schulte, Berenice and Conrad, Claudio C and Schoch, Stephan and Bethge, Johannes and Seeger, Marcus and Huber, Robert and Goeb, Madita and Arlt, Alexander and Nikolaus, Susanna and Röcken, Christoph and Schreiber, Stefan},
    title = "{Contrast enhanced endoscopic ultrasound detects early therapy response following anti-TNF-therapy in patients with ulcerative colitis}",
    journal = {Journal of Crohn's and Colitis},
    pages = {jjae034},
    year = {2024},
    month = {03},
    abstract = "{Though colonoscopy plays a crucial role in assessing active ulcerative colitis (aUC), its scope is limited to the mucosal surface. Endoscopic ultrasound (EUS) coupled with contrast-enhancement (dCEUS) can precisely quantify bowel wall thickness and microvascular circulation, potentially enabling the quantitative evaluation of inflammation.We conducted a prospective, longitudinal study to assess therapy response using dCEUS in aUC patients undergoing treatment with adalimumab (ADA) or infliximab (IFX).30 ADA- and 15 IFX-treated aUC patients were examined at baseline and at 2, 6, 14 weeks of therapy and 48 weeks of follow-up. Bowel wall thickness (BWT) was measured by EUS in the rectum. Vascularity was quantified by dCEUS using Rise Time (RT) and Time To Peak (TTP). Therapy response was defined after 14 weeks using the Mayo Score.Patients with aUC displayed a mean BWT of 3.9±0.9 mm. In case of response to ADA/IFX a significant reduction in BWT was observed after 2 weeks (p=0.04), whereas non-responders displayed no significant changes. The TTP was notably accelerated at baseline and significantly normalised by week 2 in responders (p=0.001), while non-responders exhibited no significant alterations (p=0.9). At week 2, the endoscopic Mayo score did not exhibit any changes, thus failing to predict treatment responses.dCEUS enables the early detection of therapy response in patients with aUC, which serves as a predictive marker for long term clinical success. Therefore, dCEUS serves as a diagnostic tool for assessing the probability of future therapy success.}",
    issn = {1873-9946},
    doi = {10.1093/ecco-jcc/jjae034},
    url = {https://doi.org/10.1093/ecco-jcc/jjae034},
    eprint = {https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjae034/56911128/jjae034.pdf},
}

@article { Microscopeintegratedopticalcoherencetomographyforinvivohumanbraintumordetectionwithartificialintelligence,
      author = "Patrick Kuppler and Paul Strenge and Birgit Lange and Sonja Spahr-Hess and Wolfgang Draxinger and Christian Hagel and Dirk Theisen-Kunde and Ralf Brinkmann and Robert Huber and Volker Tronnier and Matteo Mario Bonsanto",
      title = "Microscope-integrated optical coherence tomography for in vivo human brain tumor detection with artificial intelligence",
      journal = "Journal of Neurosurgery",
      year = "2024",
      publisher = "American Association of Neurological Surgeons",
      doi = "10.3171/2024.1.JNS231511",
      pages=      "1 - 9",
      url = "https://thejns.org/view/journals/j-neurosurg/aop/article-10.3171-2024.1.JNS231511/article-10.3171-2024.1.JNS231511.xml"
}

@article{Lotz:24,
author = {Simon Lotz and Madita G\"{o}b and Sven B\"{o}ttger and Linh Ha-Wissel and Jennifer Hundt and Floris Ernst and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Angiography; Biomedical imaging; In vivo imaging; Machine vision; Point clouds; Spectral domain optical coherence tomography},
number = {6},
pages = {3993--4009},
publisher = {Optica Publishing Group},
title = {Large area robotically assisted optical coherence tomography (LARA-OCT)},
volume = {15},
month = {Jun},
year = {2024},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-15-6-3993},
doi = {10.1364/BOE.525524},
abstract = {We demonstrate large-area robotically assisted optical coherence tomography (LARA-OCT), utilizing a seven-degree-of-freedom robotic arm in conjunction with a 3.3\&\#x2005;MHz swept-source OCT to raster scan samples of arbitrary shape. By combining multiple fields of view (FOV), LARA-OCT can probe a much larger area than conventional OCT. Also, nonplanar and curved surfaces like skin on arms and legs can be probed. The lenses in the LARA-OCT scanner with their normal FOV can have fewer aberrations and less complex optics compared to a single wide field design. This may be especially critical for high resolution scans. We directly use our fast MHz-OCT for tracking and stitching, making additional machine vision systems like cameras, positioning, tracking or navigation devices obsolete. This also eliminates the need for complex coordinate system registration between OCT and the machine vision system. We implemented a real time probe-to-surface control that maintains the probe alignment orthogonal to the sample by only using surface information from the OCT images. We present OCT data sets with volume sizes of 140\&\#x2009;\&\#x00D7;\&\#x2009;170\&\#x2009;\&\#x00D7;\&\#x2009;20 mm3, captured in 2.5 minutes.},
}

@article{https://doi.org/10.1002/smll.202401472,
author = {Karpf, Sebastian and Glöckner Burmeister, Nina and Dubreil, Laurence and Ghosh, Shayantani and Hollandi, Reka and Pichon, Julien and Leroux, Isabelle and Henkel, Alessandra and Lutz, Valerie and Jurkevičius, Jonas and Latshaw, Alexandra and Kilin, Vasyl and Kutscher, Tonio and Wiggert, Moritz and Saavedra-Villanueva, Oscar and Vogel, Alfred and Huber, Robert A. and Horvath, Peter and Rouger, Karl and Bonacina, Luigi},
title = {Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate},
journal = {Small},
volume = {n/a},
number = {n/a},
pages = {2401472},
keywords = {fiber lasers, harmonic imaging, multiphoton microscopy, nanoparticles, regenerative medicine, SHG, SLIDE},
doi = {https://doi.org/10.1002/smll.202401472},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202401472},
eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.202401472},
abstract = {Abstract The pre-clinical validation of cell therapies requires monitoring the biodistribution of transplanted cells in tissues of host organisms. Real-time detection of these cells in the circulatory system and identification of their aggregation state is a crucial piece of information, but necessitates deep penetration and fast imaging with high selectivity, subcellular resolution, and high throughput. In this study, multiphoton-based in-flow detection of human stem cells in whole, unfiltered blood is demonstrated in a microfluidic channel. The approach relies on a multiphoton microscope with diffractive scanning in the direction perpendicular to the flow via a rapidly wavelength-swept laser. Stem cells are labeled with metal oxide harmonic nanoparticles. Thanks to their strong and quasi-instantaneous second harmonic generation (SHG), an imaging rate in excess of 10 000 frames per second is achieved with pixel dwell times of 1 ns, a duration shorter than typical fluorescence lifetimes yet compatible with SHG. Through automated cell identification and segmentation, morphological features of each individual detected event are extracted and cell aggregates are distinguished from isolated cells. This combination of high-speed multiphoton microscopy and high-sensitivity SHG nanoparticle labeling in turbid media promises the detection of rare cells in the bloodstream for assessing novel cell-based therapies.}
}

@article{https://doi.org/10.1111/jdv.20097,
author = {Ha-Wissel, L. and Graßhoff, H. and Göb, M. and Mustafa, B. and Huber, R. and Zirpel, H. and Yasak, H. and Thaçi, D. and Hundt, J. E.},
title = {Optical coherence tomography-based imaging biomarkers for disease activity monitoring in plaque psoriasis},
journal = {Journal of the European Academy of Dermatology and Venereology},
volume = {n/a},
number = {n/a},
pages = {},
doi = {https://doi.org/10.1111/jdv.20097},
url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.20097},
eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdv.20097}
}

@ARTICLE{10568460,
  author={Riha, Rene and Jimenez, Alejandro Martinez and Venugopal, Gopika and Klufts, Marie and Huber, Robert and Podoleanu, Adrian},
  journal={IEEE Photonics Journal}, 
  title={Dispersion-Tuned Mode-Locked Laser for Swept Source OCT At 850 Nm Using a cFBG and the Pulse Modulation Technique}, 
  year={2024},
  volume={},
  number={},
  pages={1-6},
  keywords={Modulation;Dispersion;Semiconductor optical amplifiers;Optical interferometry;Optical pulses;Frequency modulation;Optical fiber amplifiers;OCT;dispersion tuning;cFBG;intensity modulator},
  doi={10.1109/JPHOT.2024.3417829}}

@article{Draxinger:24,
author = {Wolfgang Draxinger and Nicolas Detrez and Paul Strenge and Veit Danicke and Dirk Theisen-Kunde and Lion Sch\"{u}tzeck and Sonja Spahr-Hess and Patrick Kuppler and Jessica Kren and Wolfgang Wieser and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Brain imaging; Imaging systems; In vivo imaging; Magnetic resonance imaging; Speckle imaging; Spectral domain optical coherence tomography},
number = {10},
pages = {5960--5979},
publisher = {Optica Publishing Group},
title = {Microscope integrated MHz optical coherence tomography system for neurosurgery: development and clinical in-vivo imaging},
volume = {15},
month = {Oct},
year = {2024},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-15-10-5960},
doi = {10.1364/BOE.530976},
abstract = {Neurosurgical interventions on the brain are impeded by the requirement to keep damages to healthy tissue at a minimum. A new contrast channel enhancing the visual separation of malign tissue should be created. A commercially available surgical microscope was modified with adaptation optics adapting the MHz speed optical coherence tomography (OCT) imaging system developed in our group. This required the design of a scanner optics and beam delivery system overcoming constraints posed by the mechanical and optical parameters of the microscope. High quality volumetric OCT C-scans with dense sample spacing can be acquired in-vivo as part of surgical procedures within seconds and are immediately available for post-processing.},
}

@Article{Schulte2024,
author={Schulte, B.; Burhan, S.; Singh, A. P.; Draxinger, W.; Lotz, S.; Heimke, M.; Heinze, T.; Wedel, T.; Rahlves, M.; Huber, R.; Ellrichmann, M.},
title={Hochaufl{\"o}sende Rektoskopie mittels dual-mode MHz optischer Koh{\"a}renztomographie -- ein Schritt zur real time 3D Endoskopie},
journal={Z Gastroenterol},
year={2024},
month={Sep},
day={26},
publisher={Georg Thieme Verlag KG},
volume={62},
number={09},
pages={KV 355},
issn={0044-2771},
doi={10.1055/s-0044-1790019},
url={http://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0044-1790019},
url={https://doi.org/10.1055/s-0044-1790019},
language={DE}
}

Kuppler P, Strenge P, Lange B, Spahr-Hess S, Draxinger W, Hagel C, Theisen-Kunde D, Brinkmann R, Huber R, Tronnier V and Bonsanto MM (2023) The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study. Front. Oncol. 13:1151149. doi: 10.3389/fonc.2023.1151149

@article{Lamminger:23,
author = {Philipp Lamminger and Hubertus Hakert and Simon Lotz and Jan Philip Kolb and Tonio Kutscher and Sebastian Karpf and Robert Huber},
journal = {Opt. Lett.},
keywords = {Green fluorescent protein; Laser beam combining; Laser crystals; Laser imaging; Optical amplifiers; Photonic crystal lasers},
number = {14},
pages = {3713--3716},
publisher = {Optica Publishing Group},
title = {Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm},
volume = {48},
month = {Jul},
year = {2023},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-14-3713},
doi = {10.1364/OL.488181},
abstract = {Four-wave mixing (FWM) enables the generation and amplification of light in spectral regions where suitable fiber gain media are unavailable. The 1300 nm and 900 nm regions are of especially high interest for time-encoded (TICO) stimulated Raman scattering microscopy and spectro-temporal laser imaging by diffracted excitation (SLIDE) two-photon microscopy. We present a new, to the best of our knowledge, FWM setup where we shift the power of a home-built fully fiber-based master oscillator power amplifier (MOPA) at 1064 nm to the 1300-nm region of a rapidly wavelength-sweeping Fourier domain mode-locked (FDML) laser in a photonic crystal fiber (PCF) creating pulses in the 900-nm region. The resulting 900-nm light can be wavelength swept over 54 nm and has up to 2.5 kW (0.2 {\textmu}J) peak power and a narrow instantaneous spectral linewidth of 70 pm. The arbitrary pulse patterns of the MOPA and the fast wavelength tuning of the FDML laser (419 kHz) allow it to rapidly tune the FWM light enabling new and faster TICO-Raman microscopy, SLIDE imaging, and other applications.},
}

@inproceedings{10.1117/12.2670944,
author = {Nicolas Detrez and Sazgar Burhan and Paul Strenge and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann},
title = {{Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis}},
volume = {12629},
booktitle = {Emerging Technologies for Cell and Tissue Characterization II},
editor = {Seemantini K. Nadkarni and Giuliano Scarcelli},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126290M},
keywords = {Optical Coherence Elastography, Air-Jet, Phase-sensitive OCT, Histology Structure Analysis, Color-Deconvolution, Structural Tensors, Brain tumor, Tissue Characterization},
year = {2023},
doi = {10.1117/12.2670944},
URL = {https://doi.org/10.1117/12.2670944}
}

@inproceedings{10.1117/12.2670907,
author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann},
title = {{Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}},
volume = {12632},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V},
editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126321P},
keywords = {Brain Tumor, OCT, Optical Coherence Tomography, Prior Network, Glioblastoma Multiforme, Neural Network, Classification},
year = {2023},
doi = {10.1117/12.2670907},
URL = {https://doi.org/10.1117/12.2670907}
}

@inproceedings{10.1117/12.2670950,
author = {Madita G{\"o}b and Simon Lotz and Linh Ha-Wissel and Sazgar Burhan and Sven B{\"o}ttger and Floris Ernst and Jennifer Hundt and Robert Huber},
title = {{Advances in large area robotically assisted OCT (LARA-OCT): towards drive-by continuous motion imaging}},
volume = {12632},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V},
editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126321N},
abstract = {Optical coherence tomography is a powerful imaging technique to visualize and localize depth-dependent tissue structure to differentiate between healthy and pathological conditions. However, conventional OCT systems are only capable of detecting small areas. To overcome this limitation, we have developed a large area robotically assisted OCT (LARA-OCT) system for automatic acquisition of large OCT images. Using mosaic pattern acquisition and subsequent stitching, we previously demonstrated initial in vivo OCT skin images beyond 10 cm². To improve acquisition speed and reduce dead times, we here demonstrate and analyze LARA-OCT with a new drive-by continuous motion imaging protocol.},
keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, Robotically Assisted Imaging Systems, Three-dimensional image acquisition, Large Area Scanning, Skin Imaging, OCT, FDML},
year = {2023},
doi = {10.1117/12.2670950},
URL = {https://doi.org/10.1117/12.2670950}
}

@inproceedings{10.1117/12.2670957,
author = {Sazgar Burhan and Nicolas Detrez and Madita G{\"o}b and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber},
title = {{Advanced FFT-based contrast approach for MHz optical coherence elastography}},
volume = {12632},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V},
editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1263215},
abstract = {Optical coherence elastography represents mechanical characteristics of biological tissue in so-called mechanical contrast maps. In addition to the standard intensity image, the contrast map illustrates numerous mechanical tissue features that would otherwise be undetectable. This is of great interest as abnormal physiological changes influence the mechanical behavior of the tissue. We demonstrate an advanced mechanical contrast approach based on the phase signal of our 3.2 MHz optical coherence tomography system. The robustness and performance of this contrast approach is evaluated and discussed based on preliminary results. },
keywords = {Optical Coherence Tomography, OCT, Megahertz OCT, Fourier Domain Mode Locking, Optical Coherence Elastography, OCE, Phase-sensitive OCT, Biomechanics},
year = {2023},
doi = {10.1117/12.2670957},
URL = {https://doi.org/10.1117/12.2670957}
}

@inproceedings{10.1117/12.2670953,
author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Schuetz and Nicolas Detrez and Paul Strenge and Maximilian Rixius and Veit Danicke and Wolfgang Wieser and Jessica Kren and Patrick Kuppler and Sonja Spar-Hess and Matteo Mario Bonsanto M.D. and Ralf Brinkmann and Robert Huber},
title = {{Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation}},
volume = {12627},
booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III},
editor = {Zhiwei Huang and Lothar D. Lilge},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {126270W},
abstract = {Microscope integrated realtime 4D MHz-OCT operating at high scanning densities are capable of capturing additional visual contrast resolving depth and tissue. Even within a plain C-scan en-face projection structures are recognizable, that are not visible in a white light camera image. With advanced post processing methods, such as absorbtion coefficient mapping, and morphological classifiers more information is extraced. Presentation to the user in an intuitive way poses practical challenges that go beyond the implementation of a mere overlay display. We present our microscope integrated high speed 4D OCT imaging system, its clinical study use for in-vivo brain tissue imaging, and user feedback on the presentation methods we developed.},
keywords = {optical coherence tomography, neurosurgery, tissue contrast, image fusion, surgical guidance, theranostics},
year = {2023},
doi = {10.1117/12.2670953},
URL = {https://doi.org/10.1117/12.2670953}
}

@INPROCEEDINGS{10232661,
  author={Bashir, M. A. and Lotz, S. and Kluftsa, M. and Jirauschek, C. and Huberab, R.},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={1190 nm FDML laser: Challenges and Strategies}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10232661}}

@INPROCEEDINGS{10231419,
  author={Lotz, Simon and Göb, Madita and Draxinger, Wolfgang and Dick, Anneli and Huber, Robert},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={13.4 MHz FDML Laser for Intra-Surgical Optical Coherence Tomography}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10231419}}

@INPROCEEDINGS{10232019,
  author={Klufts, M. and Lotz, S. and Bashir, M. A. and Pfeiffer, T. and Mlynek, A. and Wieser, W. and Chamorovskiy, A. and Shidlovski, V. and Podoleanu, A. and Huber, R.},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Dual Amplification 850 nm FDML Laser}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10232019}}

@INPROCEEDINGS{10232141,
  author={Lamminger, Philipp and Hakert, Hubertus and Lotz, Simon and Kolb, Jan Philip and Kutscher, Tonio and Karpf, Sebastian and Huber, Robert},
  booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Four-Wave Mixing Fast Wavelength Sweeping FDML Laser with kW Peak Power at 900 nm and 1300 nm}, 
  year={2023},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEO/Europe-EQEC57999.2023.10232141}}

@article{Kutscher:23,
author = {Tonio F. Kutscher and Philipp Lamminger and Anton Gruber and Christina Leonhardt and Annika Hunold and Robert A. Huber and Sebastian Karpf},
journal = {Opt. Lett.},
keywords = {Erbium-doped fiber amplifiers; Laser imaging; Laser sources; Lidar; Multiphoton microscopy; Picosecond pulses},
number = {23},
pages = {6096--6099},
publisher = {Optica Publishing Group},
title = {Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm},
volume = {48},
month = {Dec},
year = {2023},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-23-6096},
doi = {10.1364/OL.500943},
abstract = {Swept-source lasers are versatile light sources for spectroscopy, imaging, and microscopy. Swept-source-powered multiphoton microscopy can achieve high-speed, inertia-free point scanning with MHz line-scan rates. The recently introduced spectro-temporal laser imaging by diffractive excitation (SLIDE) technique employs swept-source lasers to achieve kilohertz imaging rates by using a swept-source laser in combination with a diffraction grating for point scanning. Multiphoton microscopy at a longer wavelength, especially in the shortwave infrared (SWIR) region, can have advantages in deep tissue penetration or applications in light detection and ranging (LiDAR). Here we present a swept-source laser around 1550 nm providing high-speed wavelength agility and high peak power pulses for nonlinear excitation. The swept-source laser is a Fourier-domain mode-locked (FDML) laser operating at 326 kHz sweep rate. For high peak powers, the continuous wave (cw) output is pulse modulated to short picosecond pulses and amplified using erbium-doped fiber amplifiers (EDFAs) to peak powers of several kilowatts. This FDML-master oscillator power amplifier (FDML-MOPA) setup uses reliable, low-cost fiber components. As proof-of-principle measurement, we show third-harmonic generation (THG) using harmonic nanoparticles at the 10 MHz pulse excitation rate. This new, to the best of our knowledge, laser source provides unique performance parameters for applications in nonlinear microscopy, spectroscopy, and ranging.},
}