2021
Madita
Göb,
Sazgar
Burhan,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dez.2021. pp. EW3C.4.
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dez.2021. pp. EW3C.4.
DOI: | 10.1117/12.2616054 |
Bibtex: | ![]() @inproceedings{Gob:21, author = {Madita G\"{o}b and Sazgar Burhan and Wolfgang Draxinger and Jan Philip Kolb and Robert Huber}, booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT;Fourier domain mode locking; Image processing; Image quality; Optical coherence tomography; Temporal resolution; Three dimensional imaging}, pages = {EW3C.4}, publisher = {Optical Society of America}, title = {Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm$^2$/sec}, year = {2021}, url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-EW3C.4}, abstract = {We demonstrate a 3.3 MHz A-scan rate OCT for rapid scanning of large areas of human skin. The mosaicking performance and different OCT imaging modalities including intervolume speckle contrast are evaluated.}, } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dez.2021. pp. EW1C.7.
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dez.2021. pp. EW1C.7.
DOI: | 10.1117/12.2616044 |
Bibtex: | ![]() @inproceedings{Strenge:21, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography}, pages = {EW1C.7}, publisher = {Optical Society of America}, title = {Comparison of two optical coherence tomography systems to identify human brain tumor}, year = {2021}, url = {https://doi.org/10.1117/12.2616044}, abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.}, } |
Nicolas
Detrez,
Katharina
Rewerts,
Moritz
Matthiae,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dez.2021. pp. EW4A.10.
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dez.2021. pp. EW4A.10.
Weblink: | https://opg.optica.org/abstract.cfm?uri=ECBO-2021-EW4A.10 |
Bibtex: | ![]() @inproceedings{Detrez:21, author = {N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlueter, M.M. Bonsanto, D. Theisen-Kunde and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {EW4A.10}, publisher = {Optical Society of America}, title = {Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography}, year = {2021}, url = {https://doi.org/10.1117/12.2615022}, abstract = {A precision air puff excitation system for MHz Optical Coherence Elastography in neurosurgery was developed. It enables non-contact soft-tissue excitation down to {\textmu}N, with direct, noncontact force determination via gas flow measurement.}, } |
Katharina
Rewerts,
Moritz
Matthiae,
Nicolas
Detrez,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dez.2021. pp. ETh3A.3.
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dez.2021. pp. ETh3A.3.
Weblink: | https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETh3A.3 |
Bibtex: | ![]() @inproceedings{Rewerts2021ECBO, author = {K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlueter, M.M. Bonsanto, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {ETh3A.3}, publisher = {Optical Society of America}, title = {Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation}, year = {2021}, url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-ETh3A.3}, abstract = {Tumor discrimination from healthy tissue is often performed by haptically probing tissue elasticity. We demonstrate non-contact elastography using air-puff excitation and tissue indentation measurement by phase-sensitive OCT with a 3.2 MHz FDML-laser.}, } |
Clara
Pfäffle,
Hendrik
Spahr,
Katharina
Gercke,
Sazan
Burhan,
David
Melenberg,
Yoko
Miura,
Gereon
Hüttmann, and
Dierck
Hillmann,
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, 082021.
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, 082021.
DOI: | 10.1117/12.2577605 |
Bibtex: | ![]() @inproceedings{RN5321, author = {Pfäffle, C;Spahr, H;Gercke, K;Burhan, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D}, title = {Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer}, booktitle = {SPIE BiOS}, publisher = {SPIE}, volume = {11623}, url = {https://doi.org/10.1117/12.2577605}, type = {Conference Proceedings} } |
Hubertus
Hakert,
Matthias
Eibl,
Marie
Tillich,
Ralph
Pries,
Gereon
Hüttmann,
Ralf
Brinkmann,
Barbara
Wollenberg,
Ludwig
Bruchhage,
Sebastian
Karpf, and
Robert
Huber,
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
DOI: | 10.1364/OL.424726 |
Bibtex: | ![]() @article{Hakert2021, author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber}, title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1}, journal = {Optics Letters}, volume = {46(14)}, number = {14}, pages = {3456-3459}, keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering}, DOI = {https://doi.org/10.1364/OL.424726}, year = {2021}, type = {Journal Article} } |
Tuula
Peñate Medina,
Jan Philip
Kolb,
Gereon
Hüttmann,
Robert
Huber,
Oula
Peñate Medina,
Naomi
Larsen,
Arianna
Ferrari,
Magdalena
Rafecas,
Mark
Ellrichmann,
Mariya S.
Pravdivtseva,
Mariia
Anikeeva,
Jana
Humbert,
Marcus
Both,
Jennifer
Hundt, and
Jan-Bernd
Hövener,
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
DOI: | 10.3389/fimmu.2021.692222 |
Bibtex: | ![]() @article{PenateMedina2021, author = {Peñate Medina, T;Kolb, J P;Hüttmann, G;Huber, R;Peñate Medina, O;Ha, L;Ulloa, P;Larsen, N;Ferrari, A;Rafecas, M;Ellrichmann, M;Pravdivtseva, M S.;Anikeeva, M;Humbert, J;Both, M;Hundt, J E. and Hövener, J-B}, title = {Imaging Inflammation - From Whole Body Imaging to Cellular Resolution}, journal = {Frontiers in immunology}, keywords = {AG-Huber, MRI, PET, SPECT, optical imaging, Optical coherence tomography (OCT), precision medicine, Two-Photon microscopy (TPM), hyperpolarization}, volume = {12}, pages = {692222-692222}, ISSN = {1664-3224}, DOI = {10.3389/fimmu.2021.692222}, url = {https://pubmed.ncbi.nlm.nih.gov/34248987 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264453/}, year = {2021}, type = {Journal Article} } |
Christin
Grill,
Simon
Lotz,
Torben
Blömker,
Mark
Schmidt,
Wolfgang
Draxinger,
Jan Philip
Kolb,
Christian
Jirauschek, and
Robert
Huber,
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
DOI: | 10.1109/CLEO/Europe-EQEC52157.2021.9542126 |
Bibtex: | ![]() @INPROCEEDINGS{9542126, author={Grill, Christin and Lotz, Simon and Blömker, Torben and Schmidt, Mark and Draxinger, Wolfgang and Kolb, Jan Philip and Jirauschek, Christian and Huber, Robert}, booktitle={2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={Superposition of two independent FDML lasers}, year={2021}, volume={}, number={}, pages={1-1}, abstract={Fourier domain mode locking (FDML) is a laser operating regime, which was developed in 2005 [1] . The output of this laser is a train of optical wavelength sweeps, equivalent to extremely chirped pulses with an optical bandwidth of up to 25 THz and frequency tuning rates of >10 19 Hz/s. This laser type was developed for optical coherence tomography [2] , but found recently more and more applications like LiDAR [3] , Raman microscopy [4] or two-photon microscopy [5] . The laser’s coherence properties are relevant for a better understanding of the FDML laser itself and its applications. Because of the wide sweep range and high tuning rate, the laser linewidth cannot be measured with an RF spectrometer. Superposition with a narrowband continuous wave laser only yields phase information for small fractions of the sweep [6] . However, beat signal measurements between two independent FDML lasers with equal sweep range and direction can give information about the complete sweep.}, keywords={}, doi={10.1109/CLEO/Europe-EQEC52157.2021.9542126}, ISSN={}, month={June} } |
Tom
Pfeiffer,
Thomas
Klein,
Alexander
Mlynek,
Wolfgang
Wieser,
Simon
Lotz,
Christin
Grill, and
Robert
Huber,
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
DOI: | 10.1117/12.2583501 |
Bibtex: | ![]() @inproceedings{Pfeiffer2021, author = {T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill and R. Huber}, title = {{High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, abstract = {We demonstrate that the coherence roll-off and dynamic range of OCT systems using Fourier-domain mode-locked (FDML) lasers can be significantly improved by a fiber Fabry-Perot tunable filter (FFP-TF) with a finesse of more than 3000, a more than fivefold improvement over previous designs. In contrast to previous work, standard resampling using a pre-acquired signal (as in SD-OCT) with no k-clocking is sufficient for 20 nm and 100 nm sweep range, significantly reducing the system complexity. 3D-OCT imaging at 20 cm imaging range is demonstrated.}, keywords = {AG-Huber_FDML, AG-Huber_OCT, optical coherence tomography, FDML laser, swept source laser, high finesse, Fabry-Perot, MHz-OCT, OCT, tunable laser}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2583501} } |
Thomas
Gottschall,
Tobias
Meyer-Zedler,
Michael
Schmitt,
Robert
Huber,
Jürgen
Popp,
Andreas
Tünnermann, and
Jens
Limpert,
Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging, JRS , 06 2021.
Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging, JRS , 06 2021.
DOI: | 10.1002/jrs.6171 |
Bibtex: | ![]() @article{Gottschall2021, author = {T. Gottschall, T. Meyer-Zedler, M. Schmitt, R. Huber, J. Popp, A. Tünnermann and J. Limpert}, title = {Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging}, journal = {JRS}, keywords = { AG-Huber_NL, coherent anti-Stokes Raman scattering microscopy, four-wave mixing, nonlinear microscopy, ultrafast laser}, ISSN = {0377-0486}, url = {https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jrs.6171}, year = {2021}, type = {Journal Article} } |
Matthias
Strauch,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Ann-Kathrin
Popp,
Melanie
Wacker,
Nadine
Merg,
Jennifer
Hundt,
Sebastian
Karpf, and
Robert
Huber,
Sectioning-free virtual H&E histology with fiber-based two-photon microscopy, in SPIE BiOS , SPIE, 032021.
Sectioning-free virtual H&E histology with fiber-based two-photon microscopy, in SPIE BiOS , SPIE, 032021.
DOI: | 10.1117/12.2578334 |
Bibtex: | ![]() @inproceedings{RN5318, author = {Strauch, M;Kolb, J P;Draxinger, W;Popp, A-K;Wacker, M;Merg, N;Hundt, J;Karpf, S and Huber, R}, title = {Sectioning-free virtual H&E histology with fiber-based two-photon microscopy}, booktitle = {SPIE BiOS}, publisher = {SPIE}, volume = {11648}, Year = {2021}, DOI = {https://doi.org/10.1117/12.2578334}, url = {https://doi.org/10.1117/12.2578334}, type = {Conference Proceedings} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Christian
Hagel,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
DOI: | 10.1117/12.2578391 |
Bibtex: | ![]() @inproceedings{Strenge2021, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann}, title = {{Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {66 -- 73}, abstract = {Optical coherence tomography (OCT) has the potential to become an additional imaging modality for surgical guidance in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. Interpretation of the images, however, is still a big challenge. A method to create a labeled OCT dataset based on ex vivo brain samples is introduced. The tissue samples were embedded in an agarose mold giving them a distinctive shape before images were acquired with two OCT systems (spectral domain (SD) and swept source (SS) OCT) and histological sections were created and segmented by a neuropathologist. Based on the given shape, the corresponding OCT images for each histological image can be determined. The transfer of the labels from the histological images onto the OCT images was done with a non-affine image registration approach based on the tissue shape. It was demonstrated that finding OCT images of a tissue sample corresponding to segmented histological images without any color or laser marking is possible. It was also shown that the set labels can be transferred onto OCT images. The accuracy of method is 26 ± 11 pixel, which translates to 192 ± 75 μm for the SS-OCT and 94 ± 43 μm for the SD-OCT. The dataset consists of several hundred labeled OCT images, which can be used to train a classification algorithm.}, keywords = {AG-Huber_OCT, optical coherence tomography, OCT, image registration, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery}, year = {2021}, URL = {https://doi.org/10.1117/12.2578391} } |
Philipp
Lamminger,
Merle
Loop,
Julian
Klee,
Daniel
Weng,
Jan Philip
Kolb,
Matthias
Strauch,
Sebastian
Karpf, and
Robert
Huber,
Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups, in Multimodal Biomedical Imaging XVI , SPIE, 032021.
Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups, in Multimodal Biomedical Imaging XVI , SPIE, 032021.
DOI: | 10.1117/12.2578679 |
Bibtex: | ![]() @Conference{Lamminger2021, author = {P. Lamminger, M. Loop, J. Klee, D. Weng, J.P. Kolb, M. Strauch, S. Karpf and R. Huber}, booktitle = {Multimodal Biomedical Imaging XVI}, title = {Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups}, year = {2021}, publisher = {SPIE}, doi = {10.1117/12.2578679}, keywords = {AG-Huber_NL, AG-Huber_OCT}, } |
Christin
Grill,
Torben
Blömker,
Mark
Schmidt,
Dominic
Kastner,
Tom
Pfeiffer,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Sebastian
Karpf,
Christian
Jirauschek, and
Robert
Huber,
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
DOI: | 10.1117/12.2578293 |
Bibtex: | ![]() @inproceedings{Grill2021, author = {C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber}, title = {{A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements}}, volume = {11665}, booktitle = {Fiber Lasers XVIII: Technology and Systems}, editor = {Michalis N. Zervas}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {242 -- 247}, keywords = {AG-Huber_FDML, Fourier domain mode locking, FDML laser, laser beating , tunable laser, optical coherence tomography, OCT}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578293} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
DOI: | 10.1117/12.2578409 |
Bibtex: | ![]() @inproceedings{Strenge2021A, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, title = {{Characterization of brain tumor tissue with 1310 nm optical coherence tomography}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {74 -- 80}, abstract = {The separation of tumorous brain tissue and healthy brain tissue is still a big challenge in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. On the basis of a recently created labelled OCT dataset of ex vivo glioblastoma multiforme tumor samples the detection of brain tumor tissue and the identification of zones with varying degrees of infiltration of tumor cells was investigated. The identification was based on the optical properties, which were extracted by an exponential fit function. The results showed that a separation of tumorous tissue and healthy white matter based on these optical properties is possible. A support vector machine was trained on the optical properties to separate tumor from healthy white matter tissue, which achieved a sensitivity of 91% and a specificity of 76% on an independent training dataset.}, keywords = {AG-Huber_OCT, optical coherence tomography, OCT, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578409} } |
Simon
Lotz,
Christin
Grill,
Madita
Göb,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
DOI: | 10.1117/12.2578514 |
Bibtex: | ![]() @article{Lotz2021, author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber}, title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision}, journal = {Biomedical Optics Express}, volume = {12(5)}, keywords={AG-Huber_FDML}, pages = {2604-2616}, url = {https://doi.org/10.1364/BOE.422898}, year = {2021}, type = {Journal Article} } |
Mark
Schmidt,
Christin
Grill,
Simon
Lotz,
Tom
Pfeiffer,
Robert
Huber, and
Christian
Jirauschek,
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
DOI: | 10.1007/s00340-021-07600-1 |
Bibtex: | ![]() @Article{Schmidt2021, author = {M. Schmidt, C. Grill, S. Lotz, T. Pfeiffer, R. Hubert and C. Jirauschek}, journal = {Applied Physics B}, title = {Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime}, year = {2021}, issn = {1432-0649}, number = {5}, pages = {60}, volume = {127}, keywords={AG-Huber_FDML}, abstract = {We report on the formation of various intensity pattern types in detuned Fourier domain mode-locked (FDML) lasers and identify the corresponding operating conditions. Such patterns are a result of the complex laser dynamics and serve as an ideal tool for the study of the underlying physical processes as well as for model verification. By numerical simulation we deduce that the formation of patterns is related to the spectral position of the instantaneous laser lineshape with respect to the transmission window of the swept bandpass filter. The spectral properties of the lineshape are determined by a long-term accumulation of phase-offsets, resulting in rapid high-amplitude intensity fluctuations in the time domain due to the narrow intra-cavity bandpass filter and the fast response time of the semiconductor optical amplifier gain medium. Furthermore, we present the distribution of the duration of dips in the intensity trace by running the laser in the regime in which dominantly dips form, and give insight into their evolution over a large number of roundtrips.}, doi = {10.1007/s00340-021-07600-1}, refid = {Schmidt2021}, } |
Matthias
Strauch,
Jan Philip
Kolb,
Christian
Rose,
Nadine
Merg,
Jennifer
Hundt,
Christiane
Kümpers,
Sven
Perner,
Sebastian
Karpf, and
Robert
Huber,
Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy, in 33rd Congress of the ESP , 2021.
Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy, in 33rd Congress of the ESP , 2021.
DOI: | 10.1007/s00428-021-03157-8 |
Bibtex: | ![]() @Conference{Strauch2021, author = {M. Strauch, J.P. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf and R. Huber}, booktitle = {33rd Congress of the ESP}, title = {Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy}, year = {2021}, keywords = {AG-Huber_NL}, } |
Sonja
Jäckle,
Tim
Eixmann,
Florian
Matysiak,
Malte Maria
Sieren,
Marco
Horn,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann, and
Torben
Pätz,
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
DOI: | doi:10.1515/cdbme-2021-1004 |
Datei: | cdbme-2021-1004 |
Bibtex: | ![]() @article{Jaeckle2021c, author = {J{\"{a}}ckle, Sonja and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and P{\"{a}}tz, Torben}, doi = {doi:10.1515/cdbme-2021-1004}, journal = {Current Directions in Biomedical Engineering}, year = {2021}, number = {1}, pages = {17--20}, title = {{3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair:}}, url = {https://doi.org/10.1515/cdbme-2021-1004}, volume = {7}, } |
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Mario
Mordmüller,
Ralf
Brinkmann,
Karl
Worthmann, and
Matthias A.
Müller,
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
DOI: | https://doi.org/10.1016/j.ifacol.2021.08.552 |
Datei: | S2405896321013276 |
Bibtex: | ![]() @article{Kleyman2021, author = {Kleyman, V;Schaller, M;Wilson, M;Mordmüller, M;Brinkmann, R;Worthmann, K and Müller, M.A.}, title = {State and parameter estimation for model-based retinal laser treatment⁎⁎The collaborative project ”Temperature controlled retinal laser treatment” is funded by the German Research Foundation (DFG) under the project number 430154635 (MU 3929/3-1, WO 2056/7-1, BR 1349/6-1). MS was also funded by the DFG (grant WO 2056/2-1, project number 289034702). KW gratefully acknowledges funding by the German Research Foundation (DFG; grant WO 2056/6-1, project number 406141926)}, journal = {IFAC-PapersOnLine}, volume = {54(6)}, pages = {244-250}, ISSN = {2405-8963}, DOI = {https://doi.org/10.1016/j.ifacol.2021.08.552}, url = {https://www.sciencedirect.com/science/article/pii/S2405896321013276}, year = {2021}, type = {Journal Article} } |
Maximilian
Büttner,
Benjamin
Luger,
Wasim Abou
Moulig,
Bernd
Junker,
Carsten
Framme,
Christina
Jacobson,
Katharina
Knoll,
Amelie
Pielen, and
SRT Study Group-Theisen-Kunde, Brinkmann, Miura,Birngruber,
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
DOI: | 10.1007/s00417-020-04999-9 |
Bibtex: | ![]() @article{Büttner2021, author = {Büttner, M.;Luger, B.;Abou Moulig, W.;Junker, B.;Framme, C.;Jacobsen, C.;Knoll, K. and Pielen, A.; SRT Study Group(Brinkmann, R.; Miura, Y.)}, title = {Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {259}, number = {6}, pages = {1401-1410}, ISSN = {0721-832X (Print) 0721-832x}, DOI = {10.1007/s00417-020-04999-9}, abstract = { PURPOSE: Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% within 6 months. In this study, the efficacy of selective retina therapy (SRT) was examined in patients with therapy refractory persistent acute CSC defined by symptoms for at least 6 months and persistent subretinal fluid (SRF) despite eplerenone therapy. MATERIAL AND METHODS: This is a prospective, monocentric observational study in 17 eyes (16 patients, mean age 42 years, 2 female). SRT was performed with the approved R:GEN laser (Lutronic, South Korea), a micropulsed 527-nm Nd:YLF laser device, with a train of 30 pulses of 1.7 μs at 100-Hz repetition rate at the point of focal leakage determined by fluorescein angiography (FA) at baseline (BSL). Visits on BSL, week 4 (wk4), and week 12 (wk12) included best corrected visual acuity (BCVA, logMar), central retinal thickness (CRT) on spectral domain optical coherence tomography (SD-OCT), and FA. Statistical analysis was performed by pair-by-pair comparisons of multiple observations in each case with Bonferroni correction for multiple testing. (IBM SPSS Statistics 25®). RESULTS: Mean CRT at BSL was 387.69 ± 110.4 μm. CRT significantly decreased by 106.31 μm in wk4 (95%-KI: 21.42-191.2; p = 0.01), by 133.63 μm in wk12 (95%-KI: 50.22-217.03; p = 0.001) and by 133.81 μm (95%-KI: 48.88-218.75; p = 0.001) compared to BSL. Treatment success defined as complete resolution of SRF occurred at wk4 in 7/17 eyes (35.3%) and at wk12 in 10/17 eyes (58.8%). Re-SRT was performed in 7/17 eyes (41.2%) after an average of 107.14 ± 96.59 days. Treatment success after Re-SRT was observed in 4/6 eyes (66.6%, 12 weeks after Re-SRT). Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. Notably, eyes with treatment success showed better BCVA at all timepoints and gained more letters compared to failures. CONCLUSION: Single or repetitive SRT may be an effective and safe treatment in 2 of 3 patients suffering from acute persistent CSC after 6 months of symptoms or more. We observed complete resolution of SRF in around 60% of eyes 12 weeks after first SRT treatment and also 12 weeks after Re-SRT treatment in eyes with persistent or recurrent SRF. Results on the long-term course after SRT are still pending.}, keywords = { Central serous chorioretinopathy; Fluorescein angiography; Micropulse laser; OCT; Persistent acute disease; Selective retina treatment; Subretinal fluid. }, year = {2021}, type = {Journal Article} } |
Elisabeth
Richert,
Julia
Papenkort,
Claus
von der Burchard,
Alexa
Klettner,
Patrik
Arnold,
Ralph
Lucius,
Ralf
Brinkmann,
Carsten
Framme,
Johann
Roider, and
Jan
Tode,
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Datei: | s12886-021-02188-8 |
Bibtex: | ![]() @article{Richert2021, title = {Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy}, author = {Richert, E;Papenkort, J;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Framme, C;Roider, J and Tode, J}, year = 2021, journal = {BMC Ophthalmology}, volume = {21(1)}, pages = 412, issn = {1471-2415}, url = {https://doi.org/10.1186/s12886-021-02188-8}, keywords = {Selective retina therapy (SRT), Thermal stimulation of the retina (TSR), Age- related macular degeneration (AMD), Regeneration, Rejuvenation}, type = {Journal Article} } |
H. S. Seifert,
Single pulse optoacoustic temperature measurement, in ECBO , 2021.
Single pulse optoacoustic temperature measurement, in ECBO , 2021.
DOI: | 10.1117/12.2615897 |
Bibtex: | ![]() @inproceedings{Seifert2021, author = {Seifert, E;Abbas, H. S. and Brinkman, R}, title = {Single pulse optoacoustic temperature measurement}, booktitle = {ECBO}, DOI = {10.1117/12.2615897}, year = {2021}, type = {Conference Proceedings} } |
Aaron Doug Deen,
Spectroscopic analysis through thermoelastic optical coherence microscopy, in European Conferences on Biomedical Optics , SPIE, 2021.
Spectroscopic analysis through thermoelastic optical coherence microscopy, in European Conferences on Biomedical Optics , SPIE, 2021.
Datei: | 12.2616068 |
Bibtex: | ![]() @inproceedings{Deen2021, author = {Doug Deen, A;Pfeiffer, T;van Beusekom, H;Essers, J;van der Steen, A F.;Huber, Rt;van Soest, G and Wang, T}, title = {Spectroscopic analysis through thermoelastic optical coherence microscopy}, booktitle = {European Conferences on Biomedical Optics}, publisher = {SPIE}, year = {2021}, volume = {11924}, url = {https://doi.org/10.1117/12.2616068}, type = {Conference Proceedings} } |
Michael
Münter,
Mario
Pieper,
Tabea
Kohlfaerber,
Ernst
Bodenstorfer,
Martin
Ahrens,
Christian
Winter,
Robert
Huber,
Peter
König,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
DOI: | 10.1364/BOE.425001 |
Bibtex: | ![]() @article{Münter2021, author = {M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann and H. Schulz-Hildebrandt}, title = {Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast}, journal = {BiomedOptE}, volume = {12(10)}, Keywords = {CMOS cameras,Full field optical coherence tomography,High numerical aperture optics, Image processing,In vivo imaging,Medical imaging,Ag-Huber}, pages = {6024-6039}, DOI = {10.1364/BOE.425001}, year = {2021}, type = {Journal Article} } |
A.
Coker, and
V. V.
Yakovlev,
Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions, Photonics Research , vol. 9 (3), pp. 416-423, 2021.
Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions, Photonics Research , vol. 9 (3), pp. 416-423, 2021.
DOI: | 10.1364/PRJ.411980 |
Bibtex: | ![]() @article{Coker2021, author = {Coker, Z. N.;Liang, Xiao-Xuan;Kiester, A. S.;Noojin, G. D.;Bixler, J. N.;Ibey, B. L.;Vogel, A. and Yakovlev, V. V.}, title = {Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions}, journal = {Photonics Research}, volume = {9 (3)}, pages = {416-423}, DOI = {10.1364/PRJ.411980}, year = {2021}, type = {Journal Article} } |
Mario Mordmüller,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Datei: | 12.2615851 |
Bibtex: | ![]() @inproceedings{Mordmüller2021, author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R}, title = { Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser}, booktitle = {ECBO}, url = {https://doi.org/10.1117/12.2615851}, year = {2021}, type = {Conference Proceedings} } |
Mario
Mordmüller,
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Karl
Worthmann,
Matthias A.
Müller, and
Ralf
Brinkmann,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Datei: | 12.2615851 |
Bibtex: | ![]() @inproceedings{Mordmüller2021, author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R}, title = { Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser}, booktitle = {ECBO}, url = {https://doi.org/10.1117/12.2615851}, year = {2021}, type = {Conference Proceedings} } |
Mario
Mordmüller,
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Dirk
Theisen-Kunde,
Karl
Worthmann,
Matthias A.
Müller, and
Ralf
Brinkmann,
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Datei: | aot-2021-0041 |
Bibtex: | ![]() @article{Mordmüller-2021, author = {Mordmüller, M;Kleyman, V;Schaller, M;Wilson, M;Theisen-Kunde, D;Worthmann, K;Müller, M.A and Brinkmann, R}, title = {Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate}, journal = {Advanced Optical Technologies}, Keywords = {extended Kalman filter; laser-coagulation; model predictive control; ophthalmology; photo-acoustics}, url = {https://doi.org/10.1515/aot-2021-0041}, year = {2021}, type = {Journal Article} } |
Felix
Hilge,
Michael
Evers,
Malte
Casper,
Joshua Zev
Glahn,
Weeranut Phothong
M.D.,
Garuna Kositratna
M.D.,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann, and
Dieter Manstein
M.D.,
Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography, in Photonics in Dermatology and Plastic Surgery 2021 , Bernard Choi and Haishan Zeng, Eds. SPIE, 2021.
Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography, in Photonics in Dermatology and Plastic Surgery 2021 , Bernard Choi and Haishan Zeng, Eds. SPIE, 2021.
DOI: | 10.1117/12.2577822 |
Datei: | 12.2577822 |
Bibtex: | ![]() @inproceedings{10.1117/12.2577822, title = {Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography}, author = {Felix Hilge and Michael Evers and Malte Casper and Joshua Zev Glahn and Weeranut Phothong M.D. and Garuna Kositratna M.D. and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Dieter Manstein M.D.}, editor = {Bernard Choi and Haishan Zeng}, url = {https://doi.org/10.1117/12.2577822}, doi = {10.1117/12.2577822}, year = {2021}, date = {2021-01-01}, booktitle = {Photonics in Dermatology and Plastic Surgery 2021}, volume = {11618}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Michelle
Prasuhn,
Yoko
Miura,
Aysegül
Tura,
Felix
Rommel,
Vinodh
Kakkassery,
Svenja
Sonntag,
Salvatore
Grisanti, and
Mahdy
Ranjbar,
Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study, J ClinMed , vol. 10(11), pp. 2418, 2021.
Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study, J ClinMed , vol. 10(11), pp. 2418, 2021.
DOI: | 10.3390/jcm10112418 |
Datei: | 2418 |
Bibtex: | ![]() @article{Prasuhn2021, author = {Prasuhn, M;Miura, Y;Tura, A.;Rommel, Felix;Kakkassery, V;Sonntag, S;Grisanti, S and Ranjbar, M}, title = {Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study}, journal = {J ClinMed}, volume = {10(11)}, pages = {2418}, ISSN = {2077-0383}, url = {https://www.mdpi.com/2077-0383/10/11/2418}, year = {2021}, type = {Journal Article} } |
M Hutfilz,
Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths, in ECBO , Osa, 2021.
Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths, in ECBO , Osa, 2021.
Datei: | 12.2614437 |
Bibtex: | ![]() @inproceedings{Hutfilz2021, author = {Hutfilz, A;Theisen-Kunde, D;Bonsanto, M and Brinkman, R}, title = {Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths}, booktitle = {ECBO}, url = {https://doi.org/10.1117/12.2614437}, publisher = {Osa}, year = {2021}, type = {Conference Proceedings} } |
Christian
Burri,
Alessa
Hutfilz,
Lorenz
Grimm,
Simon
Salzmann,
Patrik
Arnold,
Boris
Považay,
Christoph
Meier,
Andreas
Ebneter,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
DOI: | https://doi.org/10.3390/app11125535 |
Datei: | 5535 |
Bibtex: | ![]() @article{Burri2021, author = {Burri, C;Hutfilz, A;Grimm, L;Salzmann, S;Arnold, P;Považay, B;Meier, C;Ebneter, A;Theisen-Kunde, D and Brinkmann, R}, title = {Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery}, journal = {Applied Sciences}, volume = {11(12)}, pages = {5535}, ISSN = {2076-3417}, DOI = { https://doi.org/10.3390/app11125535}, url = {https://www.mdpi.com/2076-3417/11/12/5535}, year = {2021}, keywords = {selective retina therapy; viability assay; photocoagulation; microbubble formation; thermomechanical damage; fringe washout; coherence-loss}, type = {Journal Article} } |
R
Schenk, and
S
Kassumeh,
Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography, Tvst , vol. 10 (13), pp. 22-22, 2021.
Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography, Tvst , vol. 10 (13), pp. 22-22, 2021.
DOI: | 10.1167/tvst.10.13.22 |
Bibtex: | ![]() @article{Schenk-2021, author = {Schenk, M S;Wartak, A;Buehler, V;Zhao, J;Tearney, G J;Birngruber, R and Kassumeh, S}, title = {Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography}, journal = {Tvst}, keywords = {corneal nerves; micro–optical coherence tomography; subbasal plexus}, volume = {10 (13)}, pages = {22-22}, ISSN = {2164-2591}, DOI = {10.1167/tvst.10.13.22}, year = {2021}, type = {Journal Article} } |
Eric
Seifert,
Jan
Tode,
Amelie
Pielen,
Dirk
Theisen-Kunde,
Carsten
Framme,
Johann
Roider,
Yoko
Miura,
Reginald
Birngruber, and
Ralf
Brinkmann,
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Datei: | S2213597921000756 |
Bibtex: | ![]() @article{Seifert2021, author = {Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R}, title = {Algorithms for optoacoustically controlled selective retina therapy (SRT)}, journal = {Photoacoustics}, Keywords = {SRT; Lasers in medicine; Ophthalmology; RPE; Selectivity; Algorithm; Retina therapy; Optoacoustics; Feedback}, volume = {25}, pages = {100316}, ISSN = {2213-5979}, url = {https://www.sciencedirect.com/science/article/pii/S2213597921000756}, year = {2021}, type = {Journal Article} } |
J. Workman
F. Vanholsbeeck, and
A.
Thambyah,
Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography, in Optical Elastography and Tissue Biomechanics VIII , Kirill V. Larin and Giuliano Scarcelli, Eds. SPIE, 2021.
Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography, in Optical Elastography and Tissue Biomechanics VIII , Kirill V. Larin and Giuliano Scarcelli, Eds. SPIE, 2021.
DOI: | 10.1117/12.2587181 |
Bibtex: | ![]() @inproceedings{10.1117/12.2587181, author = {F. Vanholsbeeck, M. Goodwin, M. Klufts, J. Workman and A. Thambyah}, title = {{Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography}}, volume = {11645}, booktitle = {Optical Elastography and Tissue Biomechanics VIII}, editor = {Kirill V. Larin and Giuliano Scarcelli}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, abstract = {Non-invasive identification, understanding and evaluation of articular cartilage damage is paramount for osteoarthritis researcher and clinician alike. Using polarisation sensitive optical coherence tomography together with impact and creep load, we use a range of metrics including birefringence to detect early signs of cartilage degeneration and gain new insights into the physiology of joint tissues}, year = {2021}, doi = {10.1117/12.2587181}, } |
Simon
Lotz,
Christin
Grill,
Madita
Göb,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
DOI: | 10.1117/12.2578514 |
Bibtex: | ![]() @inproceedings{LotzLASE2021, author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber}, title = {{Characterization of the dynamics of an FDML laser during closed-loop cavity length control}}, volume = {11665}, booktitle = {Fiber Lasers XVIII: Technology and Systems}, editor = {Michalis N. Zervas}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {236 -- 241}, abstract = {In Fourier domain mode locked (FDML) lasers, extremely precise and stable matching of the filter tuning period and light circulation time in the cavity is essential for ultra-low noise operation. During the operation of FDML lasers, the ultra-low noise mode can be lost due to temperature drifts of the already temperature stabilized cavity resulting in increased intensity noise. Until now, the filter frequency is continuously regulated to match the changing light circulation time. However, this causes the filter frequency to constantly change by a few mHz and leads to synchronization issues in cases where a fixed filter frequency is desired. We present an actively cavity length controlled FDML laser and a robust and high precision feedback loop algorithm for maintaining ultra-low noise operation. Instead of adapting the filter frequency, the cavity length is adjusted by a motorized free space beam path to match the fixed filter frequency. The closed-loop system achieves a stability of ~0.18 mHz at a sweep repetition rate of ~418 kHz which corresponds to a ratio of 4×10<sup>-10</sup>. We investigate the coherence properties during the active cavity length adjustments and observe no noise increase compared to fixed cavity length. The cavity length control is fully functional and for the first time, offers the possibility to operate an FDML laser in sweet spot mode at a fixed frequency or phase locked to an external clock. This opens new possibilities for system integration of FDML lasers.}, keywords = {AG-Huber_FDML, FDML, Fourier domain mode locking, laser beating, tunable laser, optical coherence tomography, OCT}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578514} } |
Matteo Guiseppe
Cereda,
Y.G.M.
Douven,
Koorosh
Faridpooya,
Gereon
Hüttmann,
Tim
Eixmann,
Hinnerk
Schulz-Hildebrandt,
Gernot
Kronreif,
Saskia
van Romunde,
Maarten
Beelen, and
M D.
de Smet,
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
DOI: | https://doi.org/10.1016/j.xops.2021.100085 |
Bibtex: | ![]() @article{Cereda-2021, author = {Cereda, M G;Parrulli, S;Douven, Y. G. M.;Faridpooya, K;van Romunde, S;Hüttmann, G;Eixmann, T;Schulz-Hildebrandt, H;Kronreif, G;Beelen, M and de Smet, M D.}, title = {Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery}, journal = {Ophthalmology Science}, volume = {1(4)}, pages = {100085}, ISSN = {2666-9145}, DOI = {https://doi.org/10.1016/j.xops.2021.100085}, year = {2021}, type = {Journal Article} } |
Tabea
Kohlfaerber,
Mario
Pieper,
Peter
König,
Ramtin
Rahmanzadeh,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A Izatt and James G Fujimoto, Eds. SPIE, 2021.
Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A Izatt and James G Fujimoto, Eds. SPIE, 2021.
DOI: | 10.1117/12.2583811 |
Datei: | 12.2583811 |
Bibtex: | ![]() @inproceedings{10.1117/12.2583811, title = {Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea}, author = {Tabea Kohlfaerber and Michael M\"{u}nter and Mario Pieper and Peter K\"{o}nig and Ramtin Rahmanzadeh and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt}, editor = {Joseph A Izatt and James G Fujimoto}, url = {https://doi.org/10.1117/12.2583811}, doi = {10.1117/12.2583811}, year = {2021}, date = {2021-01-01}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, volume = {11630}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Matthias
Strauch,
Jan Philip
Kolb,
Christian
Rose,
Nadine
Merg,
Christiane
Kümpers,
Sven
Perner,
Jennifer
Hundt,
Sebastian
Karpf, and
Robert
Huber,
Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging, in Virtuelle Pathologietage , 2021.
Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging, in Virtuelle Pathologietage , 2021.
Hinnerk
Schulz-Hildebrandt,
Martin
Ahrens,
Elisa
Wilken,
Cornelia
Holzhausen,
Peter
König, and
Gereon
Hüttmann,
Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI: | 10.1117/12.2575733 |
Datei: | 12.2575733 |
Bibtex: | ![]() @inproceedings{10.1117/12.2575733, title = {Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast}, author = {Hinnerk Schulz-Hildebrandt and Martin Ahrens and Michael M\"{u}nter and Elisa Wilken and Tabea Kohlf\"{a}rber and Cornelia Holzhausen and Peter K\"{o}nig and Gereon H\"{u}ttmann}, editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter}, url = {https://doi.org/10.1117/12.2575733}, doi = {10.1117/12.2575733}, year = {2021}, date = {2021-01-01}, booktitle = {Endoscopic Microscopy XVI}, volume = {11620}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
E.
Seifert,
Kleingarn
Philipp,
Svenja
Sonntag,
Dirk
Theisen-Kunde,
Salvatore
Grisanti,
Reginald
Birngruber,
Yoko
Miura, and
Ralf
Brinkmann,
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
DOI: | 10.1167/iovs.62.3.32 |
Datei: | iovs.62.3.32 |
Bibtex: | ![]() @article{Seifert2021, author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R}, title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime}, journal = {Investigative Ophthalmology & Visual Science}, volume = {62(3)}, pages = {32-32}, ISSN = {1552-5783}, DOI = {10.1167/iovs.62.3.32}, url = {https://doi.org/10.1167/iovs.62.3.32}, year = {2021}, type = {Journal Article} } |
Michel
Wunderlich,
Peter
Koch,
Helge
Sudkamp,
Michael
Münst,
Malte
Endt,
Moritz
Moltmann, and
Gereon
Hüttmann,
Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms, in Ophthalmic Technologies XXXI , Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker, Eds. SPIE, 2021. pp. 116231Q.
Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms, in Ophthalmic Technologies XXXI , Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker, Eds. SPIE, 2021. pp. 116231Q.
DOI: | 10.1117/12.2583030 |
Datei: | 12.2583030 |
Bibtex: | ![]() @inproceedings{10.1117/12.2583030, author = {Michel Wunderlich and Peter Koch and Helge Sudkamp and Michael M{\"u}nst and Malte vom Endt and Moritz Moltmann and Gereon H{\"u}ttmann}, title = {{Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms}}, volume = {11623}, booktitle = {Ophthalmic Technologies XXXI}, editor = {Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {116231Q}, keywords = {Retinal motion tracking in Off-Axis Full-Field OCT by local analy, Michel Wunderlich, Medizinsches Laserzentrum Lübeck, motion tracking, eye tracking, off-axis full-field time-domain OCT, OCT, retina}, year = {2021}, doi = {10.1117/12.2583030}, URL = {https://doi.org/10.1117/12.2583030} } |
Akika
Kyo,
Manabu
Yamamoto,
Kumiko
Hirayama,
Takeya
Kohno,
Dirk
Theisen-Kunde,
Ralf
Brinkmann,
Yoko
Miura, and
Shigeru
Honda,
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
DOI: | 10.1038/s41598-021-88372-8 |
Bibtex: | ![]() @article{Kyo-2021, author = {Kyo, A.;Yamamoto, M.;Hirayama, K.;Kohno, T.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.}, title = {Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy}, journal = {Sci Rep}, volume = {11(1)}, pages = {8973}, ISSN = {2045-2322}, DOI = {10.1038/s41598-021-88372-8}, year = {2021}, type = {Journal Article} } |
A S Krumm,
Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy, in ECBO , 2021.
Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy, in ECBO , 2021.
DOI: | https://doi.org/10.1117/12.2614447 |
Bibtex: | ![]() @inproceedings{Krumm-2021, author = {Krumm, L S;Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W;Merseburger, A S and Brinkman, R}, title = {Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy}, Year = {2021}, booktitle = {ECBO}, DOI = {https://doi.org/10.1117/12.2614447}, type = {Conference Proceedings} } |
Svenja
Sonntag,
Eric
Seifert,
Maximilian
Hamann,
Britta
Lewke,
Dirk
Theisen-Kunde,
Salvatore
Grisanti,
Ralf
Brinkmann, and
Yoko
Miura,
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
DOI: | https://www.mdpi.com/2075-1729/11/6/555 |
Datei: | 555 |
Bibtex: | ![]() @article{Miura2021-2, author = {Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y}, title = {Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States}, journal = {Life}, volume = {11(6)}, keywords = {retinal laser treatment; metabolic change; fluorescence lifetime imaging ophthalmoscopy}, pages = {555}, ISSN = {2075-1729}, url = {https://www.mdpi.com/2075-1729/11/6/555}, year = {2021}, type = {Journal Article} } |
Yoko Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO, Nippon Laser Igakkaishi , vol. advpub, 2021.
Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO, Nippon Laser Igakkaishi , vol. advpub, 2021.
DOI: | 10.2530/jslsm.jslsm-42_0008 |
Bibtex: | ![]() @article{Miura-3, author = {Miura, Y}, title = {Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO}, journal = {Nippon Laser Igakkaishi}, volume = {advpub}, DOI = {10.2530/jslsm.jslsm-42_0008}, year = {2021}, type = {Journal Article} } |
B L
Ibey, and
N.
Linz,
Front Matter: Volume 11640, in SPIE BiOS , SPIE, 2021.
Front Matter: Volume 11640, in SPIE BiOS , SPIE, 2021.
Datei: | 12.2596605 |
Bibtex: | ![]() @inproceedings{Linz2021, author = {Ibey, B L and Linz, N}, title = {Front Matter: Volume 11640}, booktitle = {SPIE BiOS}, Year = {2021}, publisher = {SPIE}, volume = {11640}, url = {https://doi.org/10.1117/12.2596605}, type = {Conference Proceedings} } |
Sonja
Jäckle,
Annkristin
Lange,
Veronica
Garcia-Vazquez,
Tim
Eixmann,
Florian
Matysiak,
Malte Maria
Sieren,
Marco
Horn,
Gereon
Hüttmann,
Hinnerk
Schulz-Hildebrandt,
Floris
Ernst,
Stefan
Heldmann,
Torben
Pätz, and
Tobias
Preusser,
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
DOI: | 10.1002/rcs.2327 |
Bibtex: | ![]() @article{Jackle2021, abstract = {Background: In endovascular aneuysm repair (EVAR) procedures, medical instruments are currently navigated with a two-dimensional imaging based guidance requiring X-rays and contrast agent. Methods: Novel approaches for obtaining the three-dimensional instrument positions are introduced. Firstly, a method based on fibre optical shape sensing, one electromagnetic sensor and a preoperative computed tomography (CT) scan is described. Secondly, an approach based on image processing using one 2D fluoroscopic image and a preoperative CT scan is introduced. Results: For the tracking based method, average errors from 1.81 to 3.13 mm and maximum errors from 3.21 to 5.46 mm were measured. For the image-based approach, average errors from 3.07 to 6.02 mm and maximum errors from 8.05 to 15.75 mm were measured. Conclusion: The tracking based method is promising for usage in EVAR procedures. For the image-based approach are applications in smaller vessels more suitable, since its errors increase with the vessel diameter.}, author = {J{\"{a}}ckle, Sonja and Lange, Annkristin and Garcia-Vazquez, Veronica and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and Ernst, Floris and Heldmann, Stefan and P{\"{a}}tz, Torben and Preusser, Tobias}, doi = {10.1002/rcs.2327}, file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Medical Robotics and Computer Assisted Surgery/J{\"{a}}ckle et al. - 2021 - Instrument localisation for endovascular aneurysm repair Comparison of two methods based on tracking systems or.pdf:pdf}, issn = {1478596X}, journal = {International Journal of Medical Robotics and Computer Assisted Surgery}, keywords = {2D/3D registration,3D localisation,computer-assisted surgery,electromagnetic tracking system,endovascular procedures,fibre optical shape sensing}, number = {6}, pages = {e2327}, year = {2021}, title = {{Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging}}, volume = {17} } |
R Theisen-Kunde,
Intraoperative Imaging in Neurosurgery, in ECBO , 2021.
Intraoperative Imaging in Neurosurgery, in ECBO , 2021.
Datei: | 12.2614855 |
Bibtex: | ![]() @inproceedings{Theisen-Kunde2021, author = {Theisen-Kunde, D;Draxinger, W;Bonsanto, M;Strenge, P;Detrez, N;Huber, R and Brinkman, R}, title = {Intraoperative Imaging in Neurosurgery}, booktitle = {ECBO}, URL = {https://doi.org/10.1117/12.2614855}, year = {2021}, type = {Conference Proceedings} } |
Martin
Ahrens,
Christian
Idel,
Peter
König,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI: | 10.1117/12.2578787 |
Datei: | 12.2578787 |
Bibtex: | ![]() @inproceedings{10.1117/12.2578787, title = {Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination}, author = {Martin Ahrens and Christian Idel and Peter K\"{o}nig and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt}, editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter}, url = {https://doi.org/10.1117/12.2578787}, doi = {10.1117/12.2578787}, year = {2021}, date = {2021-01-01}, booktitle = {Endoscopic Microscopy XVI}, volume = {11620}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |