2021

Madita Göb, Sazgar Burhan, Wolfgang Draxinger, Jan Philip Kolb, and Robert Huber,
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dez.2021. pp. EW3C.4.
DOI:10.1117/12.2616054
Bibtex: BibTeX
@inproceedings{Gob:21,
author = {Madita G\"{o}b and Sazgar Burhan and Wolfgang Draxinger and Jan Philip Kolb and Robert Huber},
booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT;Fourier domain mode locking; Image processing; Image quality; Optical coherence tomography; Temporal resolution; Three dimensional imaging},
pages = {EW3C.4},
publisher = {Optical Society of America},
title = {Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm$^2$/sec},
year = {2021},
url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-EW3C.4},
abstract = {We demonstrate a 3.3 MHz A-scan rate OCT for rapid scanning of large areas of human skin. The mosaicking performance and different OCT imaging modalities including intervolume speckle contrast are evaluated.},
}
Paul Strenge, Birgit Lange, Christin Grill, Wolfgang Draxinger, Veit Danicke, Dirk Theisen-Kunde, Heinz Handels, Matteo M. Bonsanto, Christian Hagel, Robert Huber, and Ralf Brinkmann,
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dez.2021. pp. EW1C.7.
DOI:10.1117/12.2616044
Bibtex: BibTeX
@inproceedings{Strenge:21,
author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography},
pages = {EW1C.7},
publisher = {Optical Society of America},
title = {Comparison of two optical coherence tomography systems to identify human brain tumor},
year = {2021},
url = {https://doi.org/10.1117/12.2616044},
abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.},
}
Nicolas Detrez, Katharina Rewerts, Moritz Matthiae, Steffen Buschschlüter, Matteo M. Bonsanto, Dirk Theisen-Kunde, and Ralf Brinkmann,
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dez.2021. pp. EW4A.10.
Weblink: https://opg.optica.org/abstract.cfm?uri=ECBO-2021-EW4A.10
Bibtex: BibTeX
@inproceedings{Detrez:21,
author = {N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlueter, M.M. Bonsanto, D. Theisen-Kunde and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT},
pages = {EW4A.10},
publisher = {Optical Society of America},
title = {Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography},
year = {2021},
url = {https://doi.org/10.1117/12.2615022},
abstract = {A precision air puff excitation system for MHz Optical Coherence Elastography in neurosurgery was developed. It enables non-contact soft-tissue excitation down to {\textmu}N, with direct, noncontact force determination via gas flow measurement.},
}
Katharina Rewerts, Moritz Matthiae, Nicolas Detrez, Steffen Buschschlüter, Matteo M. Bonsanto, Robert Huber, and Ralf Brinkmann,
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dez.2021. pp. ETh3A.3.
Weblink: https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETh3A.3
Bibtex: BibTeX
@inproceedings{Rewerts2021ECBO,
author = {K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlueter, M.M. Bonsanto, R. Huber and R. Brinkmann},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {AG-Huber_OCT},
pages = {ETh3A.3},
publisher = {Optical Society of America},
title = {Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation},
year = {2021},
url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-ETh3A.3},
abstract = {Tumor discrimination from healthy tissue is often performed by haptically probing tissue elasticity. We demonstrate non-contact elastography using air-puff excitation and tissue indentation measurement by phase-sensitive OCT with a 3.2 MHz FDML-laser.},
}
Clara Pfäffle, Hendrik Spahr, Katharina Gercke, Sazan Burhan, David Melenberg, Yoko Miura, Gereon Hüttmann, and Dierck Hillmann,
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, 082021.
DOI:10.1117/12.2577605
Bibtex: BibTeX
@inproceedings{RN5321,
   author = {Pfäffle, C;Spahr, H;Gercke, K;Burhan, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer},
   booktitle = {SPIE BiOS},
   publisher = {SPIE},
   volume = {11623},
   url = {https://doi.org/10.1117/12.2577605},
   type = {Conference Proceedings}
}
Hubertus Hakert, Matthias Eibl, Marie Tillich, Ralph Pries, Gereon Hüttmann, Ralf Brinkmann, Barbara Wollenberg, Ludwig Bruchhage, Sebastian Karpf, and Robert Huber,
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
DOI:10.1364/OL.424726
Bibtex: BibTeX
@article{Hakert2021,
   author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber},
   title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1},
   journal = {Optics Letters},
   volume = {46(14)},
   number = {14},
   pages = {3456-3459},
keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering},
   DOI = {https://doi.org/10.1364/OL.424726},
   year = {2021},
   type = {Journal Article}
}
Tuula Peñate Medina, Jan Philip Kolb, Gereon Hüttmann, Robert Huber, Oula Peñate Medina, Naomi Larsen, Arianna Ferrari, Magdalena Rafecas, Mark Ellrichmann, Mariya S. Pravdivtseva, Mariia Anikeeva, Jana Humbert, Marcus Both, Jennifer Hundt, and Jan-Bernd Hövener,
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
DOI:10.3389/fimmu.2021.692222
Bibtex: BibTeX
@article{PenateMedina2021,
   author = {Peñate Medina, T;Kolb, J P;Hüttmann, G;Huber, R;Peñate Medina, O;Ha, L;Ulloa, P;Larsen, N;Ferrari, A;Rafecas, M;Ellrichmann, M;Pravdivtseva, M S.;Anikeeva, M;Humbert, J;Both, M;Hundt, J E. and Hövener, J-B},
   title = {Imaging Inflammation - From Whole Body Imaging to Cellular Resolution},
   journal = {Frontiers in immunology},
keywords = {AG-Huber, MRI, PET, SPECT, optical imaging, Optical coherence tomography (OCT), precision medicine, Two-Photon microscopy (TPM), hyperpolarization},
   volume = {12},
   pages = {692222-692222},
   ISSN = {1664-3224},
   DOI = {10.3389/fimmu.2021.692222},
   url = {https://pubmed.ncbi.nlm.nih.gov/34248987
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264453/},
   year = {2021},
   type = {Journal Article}
}
Christin Grill, Simon Lotz, Torben Blömker, Mark Schmidt, Wolfgang Draxinger, Jan Philip Kolb, Christian Jirauschek, and Robert Huber,
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
DOI:10.1109/CLEO/Europe-EQEC52157.2021.9542126
Bibtex: BibTeX
@INPROCEEDINGS{9542126,
  author={Grill, Christin and Lotz, Simon and Blömker, Torben and Schmidt, Mark and Draxinger, Wolfgang and Kolb, Jan Philip and Jirauschek, Christian and Huber, Robert},
  booktitle={2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, 
  title={Superposition of two independent FDML lasers}, 
  year={2021},
  volume={},
  number={},
  pages={1-1},
  abstract={Fourier domain mode locking (FDML) is a laser operating regime, which was developed in 2005 [1] . The output of this laser is a train of optical wavelength sweeps, equivalent to extremely chirped pulses with an optical bandwidth of up to 25 THz and frequency tuning rates of >10 19 Hz/s. This laser type was developed for optical coherence tomography [2] , but found recently more and more applications like LiDAR [3] , Raman microscopy [4] or two-photon microscopy [5] . The laser’s coherence properties are relevant for a better understanding of the FDML laser itself and its applications. Because of the wide sweep range and high tuning rate, the laser linewidth cannot be measured with an RF spectrometer. Superposition with a narrowband continuous wave laser only yields phase information for small fractions of the sweep [6] . However, beat signal measurements between two independent FDML lasers with equal sweep range and direction can give information about the complete sweep.},
  keywords={},
  doi={10.1109/CLEO/Europe-EQEC52157.2021.9542126},
  ISSN={},
  month={June}
}
Tom Pfeiffer, Thomas Klein, Alexander Mlynek, Wolfgang Wieser, Simon Lotz, Christin Grill, and Robert Huber,
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
DOI:10.1117/12.2583501
Bibtex: BibTeX
@inproceedings{Pfeiffer2021,
author = {T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill and R. Huber},
title = {{High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers}},
volume = {11630},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
abstract = {We demonstrate that the coherence roll-off and dynamic range of OCT systems using Fourier-domain mode-locked (FDML) lasers can be significantly improved by a fiber Fabry-Perot tunable filter (FFP-TF) with a finesse of more than 3000, a more than fivefold improvement over previous designs. In contrast to previous work, standard resampling using a pre-acquired signal (as in SD-OCT) with no k-clocking is sufficient for 20 nm and 100 nm sweep range, significantly reducing the system complexity. 3D-OCT imaging at 20 cm imaging range is demonstrated.},
keywords = {AG-Huber_FDML, AG-Huber_OCT, optical coherence tomography, FDML laser, swept source laser, high finesse, Fabry-Perot, MHz-OCT, OCT, tunable laser},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2583501}
}
Thomas Gottschall, Tobias Meyer-Zedler, Michael Schmitt, Robert Huber, Jürgen Popp, Andreas Tünnermann, and Jens Limpert,
Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging, JRS , 06 2021.
DOI:10.1002/jrs.6171
Bibtex: BibTeX
@article{Gottschall2021,
   author = {T. Gottschall, T. Meyer-Zedler, M. Schmitt, R. Huber, J. Popp, A. Tünnermann and J. Limpert},
   title = {Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging},
   journal = {JRS},
  keywords = { AG-Huber_NL, coherent anti-Stokes Raman scattering microscopy, four-wave mixing, nonlinear
microscopy, ultrafast laser},
   ISSN = {0377-0486},   
   url = {https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jrs.6171},
   year = {2021},
   type = {Journal Article}
}
Matthias Strauch, Jan Philip Kolb, Wolfgang Draxinger, Ann-Kathrin Popp, Melanie Wacker, Nadine Merg, Jennifer Hundt, Sebastian Karpf, and Robert Huber,
Sectioning-free virtual H&E histology with fiber-based two-photon microscopy, in SPIE BiOS , SPIE, 032021.
DOI:10.1117/12.2578334
Bibtex: BibTeX
@inproceedings{RN5318,
   author = {Strauch, M;Kolb, J P;Draxinger, W;Popp, A-K;Wacker, M;Merg, N;Hundt, J;Karpf, S and Huber, R},
   title = {Sectioning-free virtual H&E histology with fiber-based two-photon microscopy},
   booktitle = {SPIE BiOS},
   publisher = {SPIE},
   volume = {11648},
Year = {2021},
   DOI = {https://doi.org/10.1117/12.2578334},
   url = {https://doi.org/10.1117/12.2578334},
   type = {Conference Proceedings}
}
Paul Strenge, Birgit Lange, Christin Grill, Wolfgang Draxinger, Veit Danicke, Dirk Theisen-Kunde, Heinz Handels, Christian Hagel, Matteo M. Bonsanto, Robert Huber, and Ralf Brinkmann,
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
DOI:10.1117/12.2578391
Bibtex: BibTeX
@inproceedings{Strenge2021,
author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann},
title = {{Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples}},
volume = {11630},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {66 -- 73},
abstract = {Optical coherence tomography (OCT) has the potential to become an additional imaging modality for surgical guidance in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. Interpretation of the images, however, is still a big challenge. A method to create a labeled OCT dataset based on ex vivo brain samples is introduced. The tissue samples were embedded in an agarose mold giving them a distinctive shape before images were acquired with two OCT systems (spectral domain (SD) and swept source (SS) OCT) and histological sections were created and segmented by a neuropathologist. Based on the given shape, the corresponding OCT images for each histological image can be determined. The transfer of the labels from the histological images onto the OCT images was done with a non-affine image registration approach based on the tissue shape. It was demonstrated that finding OCT images of a tissue sample corresponding to segmented histological images without any color or laser marking is possible. It was also shown that the set labels can be transferred onto OCT images. The accuracy of method is 26 ± 11 pixel, which translates to 192 ± 75 μm for the SS-OCT and 94 ± 43 μm for the SD-OCT. The dataset consists of several hundred labeled OCT images, which can be used to train a classification algorithm.},
keywords = {AG-Huber_OCT, optical coherence tomography, OCT, image registration, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery},
year = {2021},
URL = {https://doi.org/10.1117/12.2578391}
}
Philipp Lamminger, Merle Loop, Julian Klee, Daniel Weng, Jan Philip Kolb, Matthias Strauch, Sebastian Karpf, and Robert Huber,
Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups, in Multimodal Biomedical Imaging XVI , SPIE, 032021.
DOI:10.1117/12.2578679
Bibtex: BibTeX
@Conference{Lamminger2021,
  author    = {P. Lamminger, M. Loop, J. Klee, D. Weng, J.P. Kolb, M. Strauch, S. Karpf and R. Huber},
  booktitle = {Multimodal Biomedical Imaging XVI},
  title     = {Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups},
  year      = {2021},
  publisher = {SPIE},
  doi       = {10.1117/12.2578679},
  keywords  = {AG-Huber_NL, AG-Huber_OCT},
}
Christin Grill, Torben Blömker, Mark Schmidt, Dominic Kastner, Tom Pfeiffer, Jan Philip Kolb, Wolfgang Draxinger, Sebastian Karpf, Christian Jirauschek, and Robert Huber,
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
DOI:10.1117/12.2578293
Bibtex: BibTeX
@inproceedings{Grill2021,
author = {C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber},
title = {{A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements}},
volume = {11665},
booktitle = {Fiber Lasers XVIII: Technology and Systems},
editor = {Michalis N. Zervas},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {242 -- 247},
keywords = {AG-Huber_FDML, Fourier domain mode locking, FDML laser, laser beating , tunable laser, optical coherence tomography, OCT},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2578293}
}
Paul Strenge, Birgit Lange, Wolfgang Draxinger, Veit Danicke, Dirk Theisen-Kunde, Heinz Handels, Matteo M. Bonsanto, Christian Hagel, Robert Huber, and Ralf Brinkmann,
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
DOI:10.1117/12.2578409
Bibtex: BibTeX
@inproceedings{Strenge2021A,
author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann},
title = {{Characterization of brain tumor tissue with 1310 nm optical coherence tomography}},
volume = {11630},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {74 -- 80},
abstract = {The separation of tumorous brain tissue and healthy brain tissue is still a big challenge in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. On the basis of a recently created labelled OCT dataset of ex vivo glioblastoma multiforme tumor samples the detection of brain tumor tissue and the identification of zones with varying degrees of infiltration of tumor cells was investigated. The identification was based on the optical properties, which were extracted by an exponential fit function. The results showed that a separation of tumorous tissue and healthy white matter based on these optical properties is possible. A support vector machine was trained on the optical properties to separate tumor from healthy white matter tissue, which achieved a sensitivity of 91% and a specificity of 76% on an independent training dataset.},
keywords = {AG-Huber_OCT, optical coherence tomography, OCT, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2578409}
}
Simon Lotz, Christin Grill, Madita Göb, Wolfgang Draxinger, Jan Philip Kolb, and Robert Huber,
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
DOI:10.1117/12.2578514
Bibtex: BibTeX
@article{Lotz2021,
   author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber},
   title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision},
   journal = {Biomedical Optics Express},
   volume = {12(5)},
   keywords={AG-Huber_FDML},
   pages = {2604-2616},
   url = {https://doi.org/10.1364/BOE.422898},
   year = {2021},
   type = {Journal Article}
}
Mark Schmidt, Christin Grill, Simon Lotz, Tom Pfeiffer, Robert Huber, and Christian Jirauschek,
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
DOI:10.1007/s00340-021-07600-1
Bibtex: BibTeX
@Article{Schmidt2021,
  author   = {M. Schmidt, C. Grill, S. Lotz, T. Pfeiffer, R. Hubert and C. Jirauschek},
  journal  = {Applied Physics B},
  title    = {Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime},
  year     = {2021},
  issn     = {1432-0649},
  number   = {5},
  pages    = {60},
  volume   = {127},
keywords={AG-Huber_FDML},
  abstract = {We report on the formation of various intensity pattern types in detuned Fourier domain mode-locked (FDML) lasers and identify the corresponding operating conditions. Such patterns are a result of the complex laser dynamics and serve as an ideal tool for the study of the underlying physical processes as well as for model verification. By numerical simulation we deduce that the formation of patterns is related to the spectral position of the instantaneous laser lineshape with respect to the transmission window of the swept bandpass filter. The spectral properties of the lineshape are determined by a long-term accumulation of phase-offsets, resulting in rapid high-amplitude intensity fluctuations in the time domain due to the narrow intra-cavity bandpass filter and the fast response time of the semiconductor optical amplifier gain medium. Furthermore, we present the distribution of the duration of dips in the intensity trace by running the laser in the regime in which dominantly dips form, and give insight into their evolution over a large number of roundtrips.},
  doi      = {10.1007/s00340-021-07600-1},
  refid    = {Schmidt2021},
}
Matthias Strauch, Jan Philip Kolb, Christian Rose, Nadine Merg, Jennifer Hundt, Christiane Kümpers, Sven Perner, Sebastian Karpf, and Robert Huber,
Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy, in 33rd Congress of the ESP , 2021.
DOI:10.1007/s00428-021-03157-8
Bibtex: BibTeX
@Conference{Strauch2021,
  author    = {M. Strauch, J.P. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf and R. Huber},
  booktitle = {33rd Congress of the ESP},
  title     = {Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy},
  year      = {2021},
  keywords  = {AG-Huber_NL},
}
Sonja Jäckle, Tim Eixmann, Florian Matysiak, Malte Maria Sieren, Marco Horn, Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, and Torben Pätz,
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
DOI:doi:10.1515/cdbme-2021-1004
Datei: cdbme-2021-1004
Bibtex: BibTeX
@article{Jaeckle2021c,
author = {J{\"{a}}ckle, Sonja and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and P{\"{a}}tz, Torben},
doi = {doi:10.1515/cdbme-2021-1004},
journal = {Current Directions in Biomedical Engineering},
year = {2021},
number = {1},
pages = {17--20},
title = {{3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair:}},
url = {https://doi.org/10.1515/cdbme-2021-1004},
volume = {7},
}
Viktoria Kleymann, Manuel A. Schaller, Mitsuru Wilson, Mario Mordmüller, Ralf Brinkmann, Karl Worthmann, and Matthias A. Müller,
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
DOI:https://doi.org/10.1016/j.ifacol.2021.08.552
Datei: S2405896321013276
Bibtex: BibTeX
@article{Kleyman2021,
   author = {Kleyman, V;Schaller, M;Wilson, M;Mordmüller, M;Brinkmann, R;Worthmann, K and Müller, M.A.},
   title = {State and parameter estimation for model-based retinal laser treatment⁎⁎The collaborative project ”Temperature controlled retinal laser treatment” is funded by the German Research Foundation (DFG) under the project number 430154635 (MU 3929/3-1, WO 2056/7-1, BR 1349/6-1). MS was also funded by the DFG (grant WO 2056/2-1, project number 289034702). KW gratefully acknowledges funding by the German Research Foundation (DFG; grant WO 2056/6-1, project number 406141926)},
   journal = {IFAC-PapersOnLine},
   volume = {54(6)},
 
   pages = {244-250},
   ISSN = {2405-8963},
   DOI = {https://doi.org/10.1016/j.ifacol.2021.08.552},
   url = {https://www.sciencedirect.com/science/article/pii/S2405896321013276},
   year = {2021},
   type = {Journal Article}
}
Maximilian Büttner, Benjamin Luger, Wasim Abou Moulig, Bernd Junker, Carsten Framme, Christina Jacobson, Katharina Knoll, Amelie Pielen, and SRT Study Group-Theisen-Kunde, Brinkmann, Miura,Birngruber,
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
DOI:10.1007/s00417-020-04999-9
Bibtex: BibTeX
@article{Büttner2021,
   author = {Büttner, M.;Luger, B.;Abou Moulig, W.;Junker, B.;Framme, C.;Jacobsen, C.;Knoll, K. and Pielen, A.; SRT Study Group(Brinkmann, R.; Miura, Y.)},
   title = {Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   volume = {259},
   number = {6},
   pages = {1401-1410},
   ISSN = {0721-832X (Print)
0721-832x},
   DOI = {10.1007/s00417-020-04999-9},
abstract = { PURPOSE: Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% within 6 months. In this study, the efficacy of selective retina therapy (SRT) was examined in patients with therapy refractory persistent acute CSC defined by symptoms for at least 6 months and persistent subretinal fluid (SRF) despite eplerenone therapy. MATERIAL AND METHODS: This is a prospective, monocentric observational study in 17 eyes (16 patients, mean age 42 years, 2 female). SRT was performed with the approved R:GEN laser (Lutronic, South Korea), a micropulsed 527-nm Nd:YLF laser device, with a train of 30 pulses of 1.7 μs at 100-Hz repetition rate at the point of focal leakage determined by fluorescein angiography (FA) at baseline (BSL). Visits on BSL, week 4 (wk4), and week 12 (wk12) included best corrected visual acuity (BCVA, logMar), central retinal thickness (CRT) on spectral domain optical coherence tomography (SD-OCT), and FA. Statistical analysis was performed by pair-by-pair comparisons of multiple observations in each case with Bonferroni correction for multiple testing. (IBM SPSS Statistics 25®). RESULTS: Mean CRT at BSL was 387.69 ± 110.4 μm. CRT significantly decreased by 106.31 μm in wk4 (95%-KI: 21.42-191.2; p = 0.01), by 133.63 μm in wk12 (95%-KI: 50.22-217.03; p = 0.001) and by 133.81 μm (95%-KI: 48.88-218.75; p = 0.001) compared to BSL. Treatment success defined as complete resolution of SRF occurred at wk4 in 7/17 eyes (35.3%) and at wk12 in 10/17 eyes (58.8%). Re-SRT was performed in 7/17 eyes (41.2%) after an average of 107.14 ± 96.59 days. Treatment success after Re-SRT was observed in 4/6 eyes (66.6%, 12 weeks after Re-SRT). Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. Notably, eyes with treatment success showed better BCVA at all timepoints and gained more letters compared to failures. CONCLUSION: Single or repetitive SRT may be an effective and safe treatment in 2 of 3 patients suffering from acute persistent CSC after 6 months of symptoms or more. We observed complete resolution of SRF in around 60% of eyes 12 weeks after first SRT treatment and also 12 weeks after Re-SRT treatment in eyes with persistent or recurrent SRF. Results on the long-term course after SRT are still pending.},
keywords = { Central serous chorioretinopathy; Fluorescein angiography; Micropulse laser; OCT; Persistent acute disease; Selective retina treatment; Subretinal fluid. },
   year = {2021},
   type = {Journal Article}
}
Elisabeth Richert, Julia Papenkort, Claus von der Burchard, Alexa Klettner, Patrik Arnold, Ralph Lucius, Ralf Brinkmann, Carsten Framme, Johann Roider, and Jan Tode,
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Datei: s12886-021-02188-8
Bibtex: BibTeX
@article{Richert2021,
   title        = {Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy},
   author       = {Richert, E;Papenkort, J;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Framme, C;Roider, J and Tode, J},
   year         = 2021,
   journal      = {BMC Ophthalmology},
   volume       = {21(1)},
   pages        = 412,
   issn         = {1471-2415},
   url          = {https://doi.org/10.1186/s12886-021-02188-8},
   keywords     = {Selective retina therapy (SRT), Thermal stimulation of the retina (TSR),  Age- related macular  degeneration (AMD), Regeneration, Rejuvenation},
   type         = {Journal Article}
}
H. S. Seifert,
Single pulse optoacoustic temperature measurement, in ECBO , 2021.
DOI:10.1117/12.2615897
Bibtex: BibTeX
@inproceedings{Seifert2021,
   author = {Seifert, E;Abbas, H. S. and Brinkman, R},
   title = {Single pulse optoacoustic temperature measurement},
   booktitle = {ECBO},
DOI = {10.1117/12.2615897},
year = {2021},
   type = {Conference Proceedings}
}
Aaron Doug Deen,
Spectroscopic analysis through thermoelastic optical coherence microscopy, in European Conferences on Biomedical Optics , SPIE, 2021.
Datei: 12.2616068
Bibtex: BibTeX
@inproceedings{Deen2021,
   author = {Doug Deen, A;Pfeiffer, T;van Beusekom, H;Essers, J;van der Steen, A F.;Huber, Rt;van Soest, G and Wang, T},
   title = {Spectroscopic analysis through thermoelastic optical coherence microscopy},
   booktitle = {European Conferences on Biomedical Optics},
   publisher = {SPIE},
year = {2021},
   volume = {11924},
   url = {https://doi.org/10.1117/12.2616068},
   type = {Conference Proceedings}
}
Michael Münter, Mario Pieper, Tabea Kohlfaerber, Ernst Bodenstorfer, Martin Ahrens, Christian Winter, Robert Huber, Peter König, Gereon Hüttmann, and Hinnerk Schulz-Hildebrandt,
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
DOI:10.1364/BOE.425001
Bibtex: BibTeX
@article{Münter2021,
   author = {M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann and H. Schulz-Hildebrandt},
   title = {Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast},
   journal = {BiomedOptE},
   volume = {12(10)},
   Keywords = {CMOS cameras,Full field optical coherence tomography,High numerical aperture optics, Image processing,In vivo imaging,Medical imaging,Ag-Huber},
   pages = {6024-6039},
   DOI = {10.1364/BOE.425001},
  
   year = {2021},
   type = {Journal Article}
}
A. Coker, and V. V. Yakovlev,
Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions, Photonics Research , vol. 9 (3), pp. 416-423, 2021.
DOI:10.1364/PRJ.411980
Bibtex: BibTeX
@article{Coker2021,
   author = {Coker, Z. N.;Liang, Xiao-Xuan;Kiester, A. S.;Noojin, G. D.;Bixler, J. N.;Ibey, B. L.;Vogel, A. and Yakovlev, V. V.},
   title = {Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions},
   journal = {Photonics Research},
   volume = {9 (3)},
   pages = {416-423},
   DOI = {10.1364/PRJ.411980},
 
   year = {2021},
   type = {Journal Article}
}
Mario Mordmüller,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Datei: 12.2615851
Bibtex: BibTeX
@inproceedings{Mordmüller2021,
   author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R},
   title = { Towards Model-based Control Techniques for Retinal Laser
Treatment Using Only One Laser},
   booktitle = {ECBO},
url = {https://doi.org/10.1117/12.2615851},
year = {2021},
   type = {Conference Proceedings}
}
Mario Mordmüller, Viktoria Kleymann, Manuel A. Schaller, Mitsuru Wilson, Karl Worthmann, Matthias A. Müller, and Ralf Brinkmann,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Datei: 12.2615851
Bibtex: BibTeX
@inproceedings{Mordmüller2021,
   author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R},
   title = { Towards Model-based Control Techniques for Retinal Laser
Treatment Using Only One Laser},
   booktitle = {ECBO},
url = {https://doi.org/10.1117/12.2615851},
year = {2021},
   type = {Conference Proceedings}
}
Mario Mordmüller, Viktoria Kleymann, Manuel A. Schaller, Mitsuru Wilson, Dirk Theisen-Kunde, Karl Worthmann, Matthias A. Müller, and Ralf Brinkmann,
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Datei: aot-2021-0041
Bibtex: BibTeX
@article{Mordmüller-2021,
   author = {Mordmüller, M;Kleyman, V;Schaller, M;Wilson, M;Theisen-Kunde, D;Worthmann, K;Müller, M.A and Brinkmann, R},
   title = {Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate},
   journal = {Advanced Optical Technologies},
Keywords = {extended Kalman filter; laser-coagulation; model predictive control; ophthalmology; photo-acoustics},
  
   url = {https://doi.org/10.1515/aot-2021-0041},
   year = {2021},
   type = {Journal Article}
}
Felix Hilge, Michael Evers, Malte Casper, Joshua Zev Glahn, Weeranut Phothong M.D., Garuna Kositratna M.D., Hinnerk Schulz-Hildebrandt, Gereon Hüttmann, and Dieter Manstein M.D.,
Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography, in Photonics in Dermatology and Plastic Surgery 2021 , Bernard Choi and Haishan Zeng, Eds. SPIE, 2021.
DOI:10.1117/12.2577822
Datei: 12.2577822
Bibtex: BibTeX
@inproceedings{10.1117/12.2577822,

title = {Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography},

author = {Felix Hilge and Michael Evers and Malte Casper and Joshua Zev Glahn and Weeranut Phothong M.D. and Garuna Kositratna M.D. and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Dieter Manstein M.D.},

editor = {Bernard Choi and Haishan Zeng},

url = {https://doi.org/10.1117/12.2577822},

doi = {10.1117/12.2577822},

year  = {2021},

date = {2021-01-01},

booktitle = {Photonics in Dermatology and Plastic Surgery 2021},

volume = {11618},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
Michelle Prasuhn, Yoko Miura, Aysegül Tura, Felix Rommel, Vinodh Kakkassery, Svenja Sonntag, Salvatore Grisanti, and Mahdy Ranjbar,
Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study, J ClinMed , vol. 10(11), pp. 2418, 2021.
DOI:10.3390/jcm10112418
Datei: 2418
Bibtex: BibTeX
@article{Prasuhn2021,
   author = {Prasuhn, M;Miura, Y;Tura, A.;Rommel, Felix;Kakkassery, V;Sonntag, S;Grisanti, S and Ranjbar, M},
   title = {Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study},
   journal = {J ClinMed},
   volume = {10(11)},
   
   pages = {2418},
   ISSN = {2077-0383},
   url = {https://www.mdpi.com/2077-0383/10/11/2418},
   year = {2021},
   type = {Journal Article}
}
M Hutfilz,
Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths, in ECBO , Osa, 2021.
Datei: 12.2614437
Bibtex: BibTeX
@inproceedings{Hutfilz2021,
   author = {Hutfilz, A;Theisen-Kunde, D;Bonsanto, M and Brinkman, R},
   title = {Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths},
   booktitle = {ECBO},
url = {https://doi.org/10.1117/12.2614437},
   publisher = {Osa},
year = {2021},
   type = {Conference Proceedings}
}
Christian Burri, Alessa Hutfilz, Lorenz Grimm, Simon Salzmann, Patrik Arnold, Boris Považay, Christoph Meier, Andreas Ebneter, Dirk Theisen-Kunde, and Ralf Brinkmann,
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
DOI:https://doi.org/10.3390/app11125535
Datei: 5535
Bibtex: BibTeX
@article{Burri2021,
   author = {Burri, C;Hutfilz, A;Grimm, L;Salzmann, S;Arnold, P;Považay, B;Meier, C;Ebneter, A;Theisen-Kunde, D and Brinkmann, R},
   title = {Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery},
   journal = {Applied Sciences},
   volume = {11(12)},
   
   pages = {5535},
   ISSN = {2076-3417},
   DOI = { https://doi.org/10.3390/app11125535},
   url = {https://www.mdpi.com/2076-3417/11/12/5535},
   year = {2021},
keywords = {selective retina therapy; viability assay; photocoagulation; microbubble formation;
thermomechanical damage; fringe washout; coherence-loss},
   type = {Journal Article}
}
R Schenk, and S Kassumeh,
Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography, Tvst , vol. 10 (13), pp. 22-22, 2021.
DOI:10.1167/tvst.10.13.22
Bibtex: BibTeX
@article{Schenk-2021,
   author = {Schenk, M S;Wartak, A;Buehler, V;Zhao, J;Tearney, G J;Birngruber, R and Kassumeh, S},
   title = {Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography},
   journal = {Tvst},
keywords = {corneal nerves; micro–optical coherence tomography; subbasal plexus},
   volume = {10 (13)},
   pages = {22-22},
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.10.13.22},

   year = {2021},
   type = {Journal Article}
}

Eric Seifert, Jan Tode, Amelie Pielen, Dirk Theisen-Kunde, Carsten Framme, Johann Roider, Yoko Miura, Reginald Birngruber, and Ralf Brinkmann,
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Datei: S2213597921000756
Bibtex: BibTeX
@article{Seifert2021,
   author = {Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R},
   title = {Algorithms for optoacoustically controlled selective retina therapy (SRT)},
   journal = {Photoacoustics},
Keywords = {SRT; Lasers in medicine; Ophthalmology; RPE; Selectivity; Algorithm; Retina therapy; Optoacoustics; Feedback},
   volume = {25},
   pages = {100316},
   ISSN = {2213-5979},
   url = {https://www.sciencedirect.com/science/article/pii/S2213597921000756},
   year = {2021},
   type = {Journal Article}
}
J. Workman F. Vanholsbeeck, and A. Thambyah,
Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography, in Optical Elastography and Tissue Biomechanics VIII , Kirill V. Larin and Giuliano Scarcelli, Eds. SPIE, 2021.
DOI:10.1117/12.2587181
Bibtex: BibTeX
@inproceedings{10.1117/12.2587181,
author = {F. Vanholsbeeck, M. Goodwin, M. Klufts, J. Workman and A. Thambyah},
title = {{Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography}},
volume = {11645},
booktitle = {Optical Elastography and Tissue Biomechanics VIII},
editor = {Kirill V. Larin and Giuliano Scarcelli},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
abstract = {Non-invasive identification, understanding and evaluation of articular cartilage damage is paramount for osteoarthritis researcher and clinician alike. Using polarisation sensitive optical coherence tomography together with impact and creep load, we use a range of metrics including birefringence to detect early signs of cartilage degeneration and gain new insights into the physiology of joint tissues},
year = {2021},
doi = {10.1117/12.2587181},
}
Simon Lotz, Christin Grill, Madita Göb, Wolfgang Draxinger, Jan Philip Kolb, and Robert Huber,
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
DOI:10.1117/12.2578514
Bibtex: BibTeX
@inproceedings{LotzLASE2021,
author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber},
title = {{Characterization of the dynamics of an FDML laser during closed-loop cavity length control}},
volume = {11665},
booktitle = {Fiber Lasers XVIII: Technology and Systems},
editor = {Michalis N. Zervas},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {236 -- 241},
abstract = {In Fourier domain mode locked (FDML) lasers, extremely precise and stable matching of the filter tuning period and light circulation time in the cavity is essential for ultra-low noise operation. During the operation of FDML lasers, the ultra-low noise mode can be lost due to temperature drifts of the already temperature stabilized cavity resulting in increased intensity noise. Until now, the filter frequency is continuously regulated to match the changing light circulation time. However, this causes the filter frequency to constantly change by a few mHz and leads to synchronization issues in cases where a fixed filter frequency is desired. We present an actively cavity length controlled FDML laser and a robust and high precision feedback loop algorithm for maintaining ultra-low noise operation. Instead of adapting the filter frequency, the cavity length is adjusted by a motorized free space beam path to match the fixed filter frequency. The closed-loop system achieves a stability of ~0.18 mHz at a sweep repetition rate of ~418 kHz which corresponds to a ratio of 4×10<sup>-10</sup>. We investigate the coherence properties during the active cavity length adjustments and observe no noise increase compared to fixed cavity length. The cavity length control is fully functional and for the first time, offers the possibility to operate an FDML laser in sweet spot mode at a fixed frequency or phase locked to an external clock. This opens new possibilities for system integration of FDML lasers.},
keywords = {AG-Huber_FDML, FDML, Fourier domain mode locking, laser beating, tunable laser, optical coherence tomography, OCT},
year = {2021},
URL = {hhttps://doi.org/10.1117/12.2578514}
}
Matteo Guiseppe Cereda, Y.G.M. Douven, Koorosh Faridpooya, Gereon Hüttmann, Tim Eixmann, Hinnerk Schulz-Hildebrandt, Gernot Kronreif, Saskia van Romunde, Maarten Beelen, and M D. de Smet,
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
DOI:https://doi.org/10.1016/j.xops.2021.100085
Bibtex: BibTeX
@article{Cereda-2021,
   author = {Cereda, M G;Parrulli, S;Douven, Y. G. M.;Faridpooya, K;van Romunde, S;Hüttmann, G;Eixmann, T;Schulz-Hildebrandt, H;Kronreif, G;Beelen, M and de Smet, M D.},
   title = {Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery},
   journal = {Ophthalmology Science},
   volume = {1(4)},
  
   pages = {100085},
   ISSN = {2666-9145},
   DOI = {https://doi.org/10.1016/j.xops.2021.100085},
  
   year = {2021},
   type = {Journal Article}
}
Tabea Kohlfaerber, Mario Pieper, Peter König, Ramtin Rahmanzadeh, Gereon Hüttmann, and Hinnerk Schulz-Hildebrandt,
Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A Izatt and James G Fujimoto, Eds. SPIE, 2021.
DOI:10.1117/12.2583811
Datei: 12.2583811
Bibtex: BibTeX
@inproceedings{10.1117/12.2583811,

title = {Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea},

author = {Tabea Kohlfaerber and Michael M\"{u}nter and Mario Pieper and Peter K\"{o}nig and Ramtin Rahmanzadeh and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},

editor = {Joseph A Izatt and James G Fujimoto},

url = {https://doi.org/10.1117/12.2583811},

doi = {10.1117/12.2583811},

year  = {2021},

date = {2021-01-01},

booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},

volume = {11630},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
Matthias Strauch, Jan Philip Kolb, Christian Rose, Nadine Merg, Christiane Kümpers, Sven Perner, Jennifer Hundt, Sebastian Karpf, and Robert Huber,
Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging, in Virtuelle Pathologietage , 2021.
Bibtex: BibTeX
@Conference{Strauch2021b,
  author    = {M. Strauch, J.P. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf and R. Hubert},
  booktitle = {Virtuelle Pathologietage},
  title     = {Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging},
  year      = {2021},
  keywords  = {AG-Huber_NL},
}
Hinnerk Schulz-Hildebrandt, Martin Ahrens, Elisa Wilken, Cornelia Holzhausen, Peter König, and Gereon Hüttmann,
Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI:10.1117/12.2575733
Datei: 12.2575733
Bibtex: BibTeX
@inproceedings{10.1117/12.2575733,

title = {Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast},

author = {Hinnerk Schulz-Hildebrandt and Martin Ahrens and Michael M\"{u}nter and Elisa Wilken and Tabea Kohlf\"{a}rber and Cornelia Holzhausen and Peter K\"{o}nig and Gereon H\"{u}ttmann},

editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter},

url = {https://doi.org/10.1117/12.2575733},

doi = {10.1117/12.2575733},

year  = {2021},

date = {2021-01-01},

booktitle = {Endoscopic Microscopy XVI},

volume = {11620},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
E. Seifert, Kleingarn Philipp, Svenja Sonntag, Dirk Theisen-Kunde, Salvatore Grisanti, Reginald Birngruber, Yoko Miura, and Ralf Brinkmann,
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
DOI:10.1167/iovs.62.3.32
Datei: iovs.62.3.32
Bibtex: BibTeX
@article{Seifert2021,
   author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R},
   title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {62(3)},
  
   pages = {32-32},
   ISSN = {1552-5783},
   DOI = {10.1167/iovs.62.3.32},
   url = {https://doi.org/10.1167/iovs.62.3.32},
   year = {2021},
   type = {Journal Article}
}
Michel Wunderlich, Peter Koch, Helge Sudkamp, Michael Münst, Malte Endt, Moritz Moltmann, and Gereon Hüttmann,
Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms, in Ophthalmic Technologies XXXI , Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker, Eds. SPIE, 2021. pp. 116231Q.
DOI:10.1117/12.2583030
Datei: 12.2583030
Bibtex: BibTeX
@inproceedings{10.1117/12.2583030,
author = {Michel Wunderlich and Peter Koch and Helge Sudkamp and Michael M{\"u}nst and Malte vom Endt and Moritz Moltmann and Gereon H{\"u}ttmann},
title = {{Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms}},
volume = {11623},
booktitle = {Ophthalmic Technologies XXXI},
editor = {Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {116231Q},
keywords = {Retinal motion tracking in Off-Axis Full-Field OCT by local analy, Michel Wunderlich, Medizinsches Laserzentrum Lübeck, motion tracking, eye tracking, off-axis full-field time-domain OCT, OCT, retina},
year = {2021},
doi = {10.1117/12.2583030},
URL = {https://doi.org/10.1117/12.2583030}
}
Akika Kyo, Manabu Yamamoto, Kumiko Hirayama, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, and Shigeru Honda,
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
DOI:10.1038/s41598-021-88372-8
Bibtex: BibTeX
@article{Kyo-2021,
   author = {Kyo, A.;Yamamoto, M.;Hirayama, K.;Kohno, T.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.},
   title = {Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy},
   journal = {Sci Rep},
   volume = {11(1)},
  
   pages = {8973},
   ISSN = {2045-2322},
   DOI = {10.1038/s41598-021-88372-8},
   year = {2021},
   type = {Journal Article}
}
A S Krumm,
Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy, in ECBO , 2021.
DOI:https://doi.org/10.1117/12.2614447
Bibtex: BibTeX
@inproceedings{Krumm-2021,
   author = {Krumm, L S;Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W;Merseburger, A S and Brinkman, R},
   title = {Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy},
Year = {2021},
   booktitle = {ECBO},
DOI = {https://doi.org/10.1117/12.2614447},
   type = {Conference Proceedings}
}
Svenja Sonntag, Eric Seifert, Maximilian Hamann, Britta Lewke, Dirk Theisen-Kunde, Salvatore Grisanti, Ralf Brinkmann, and Yoko Miura,
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
DOI:https://www.mdpi.com/2075-1729/11/6/555
Datei: 555
Bibtex: BibTeX
@article{Miura2021-2,
   author = {Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y},
   title = {Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States},
   journal = {Life},
   volume = {11(6)},
  keywords = {retinal laser treatment; metabolic change; fluorescence lifetime imaging ophthalmoscopy},
   pages = {555},
   ISSN = {2075-1729},
   url = {https://www.mdpi.com/2075-1729/11/6/555},
   year = {2021},
   type = {Journal Article}
}
Yoko Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO, Nippon Laser Igakkaishi , vol. advpub, 2021.
DOI:10.2530/jslsm.jslsm-42_0008
Bibtex: BibTeX
@article{Miura-3,
   author = {Miura, Y},
   title = {Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO},
   journal = {Nippon Laser Igakkaishi},
   volume = {advpub},
   DOI = {10.2530/jslsm.jslsm-42_0008},
   year = {2021},
   type = {Journal Article}
}
B L Ibey, and N. Linz,
Front Matter: Volume 11640, in SPIE BiOS , SPIE, 2021.
Datei: 12.2596605
Bibtex: BibTeX
@inproceedings{Linz2021,
   author = {Ibey, B L and Linz, N},
   title = {Front Matter: Volume 11640},
   booktitle = {SPIE BiOS},
Year = {2021},
   publisher = {SPIE},
   volume = {11640},
   url = {https://doi.org/10.1117/12.2596605},
   type = {Conference Proceedings}
}
Sonja Jäckle, Annkristin Lange, Veronica Garcia-Vazquez, Tim Eixmann, Florian Matysiak, Malte Maria Sieren, Marco Horn, Gereon Hüttmann, Hinnerk Schulz-Hildebrandt, Floris Ernst, Stefan Heldmann, Torben Pätz, and Tobias Preusser,
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
DOI:10.1002/rcs.2327
Bibtex: BibTeX
@article{Jackle2021,
abstract = {Background: In endovascular aneuysm repair (EVAR) procedures, medical instruments are currently navigated with a two-dimensional imaging based guidance requiring X-rays and contrast agent. Methods: Novel approaches for obtaining the three-dimensional instrument positions are introduced. Firstly, a method based on fibre optical shape sensing, one electromagnetic sensor and a preoperative computed tomography (CT) scan is described. Secondly, an approach based on image processing using one 2D fluoroscopic image and a preoperative CT scan is introduced. Results: For the tracking based method, average errors from 1.81 to 3.13 mm and maximum errors from 3.21 to 5.46 mm were measured. For the image-based approach, average errors from 3.07 to 6.02 mm and maximum errors from 8.05 to 15.75 mm were measured. Conclusion: The tracking based method is promising for usage in EVAR procedures. For the image-based approach are applications in smaller vessels more suitable, since its errors increase with the vessel diameter.},
author = {J{\"{a}}ckle, Sonja and Lange, Annkristin and Garcia-Vazquez, Veronica and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and Ernst, Floris and Heldmann, Stefan and P{\"{a}}tz, Torben and Preusser, Tobias},
doi = {10.1002/rcs.2327},
file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Medical Robotics and Computer Assisted Surgery/J{\"{a}}ckle et al. - 2021 - Instrument localisation for endovascular aneurysm repair Comparison of two methods based on tracking systems or.pdf:pdf},
issn = {1478596X},
journal = {International Journal of Medical Robotics and Computer Assisted Surgery},
keywords = {2D/3D registration,3D localisation,computer-assisted surgery,electromagnetic tracking system,endovascular procedures,fibre optical shape sensing},
number = {6},
pages = {e2327},
year = {2021},
title = {{Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging}},
volume = {17}
}
R Theisen-Kunde,
Intraoperative Imaging in Neurosurgery, in ECBO , 2021.
Datei: 12.2614855
Bibtex: BibTeX
@inproceedings{Theisen-Kunde2021,
   author = {Theisen-Kunde, D;Draxinger, W;Bonsanto, M;Strenge, P;Detrez, N;Huber, R and Brinkman, R},
   title = {Intraoperative Imaging in Neurosurgery},
   booktitle = {ECBO},
URL = {https://doi.org/10.1117/12.2614855},
year = {2021},
   type = {Conference Proceedings}
}
Martin Ahrens, Christian Idel, Peter König, Gereon Hüttmann, and Hinnerk Schulz-Hildebrandt,
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI:10.1117/12.2578787
Datei: 12.2578787
Bibtex: BibTeX
@inproceedings{10.1117/12.2578787,

title = {Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination},

author = {Martin Ahrens and Christian Idel and Peter K\"{o}nig and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},

editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter},

url = {https://doi.org/10.1117/12.2578787},

doi = {10.1117/12.2578787},

year  = {2021},

date = {2021-01-01},

booktitle = {Endoscopic Microscopy XVI},

volume = {11620},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}