2018

Josef Maertz, Jan Philip Kolb, Thomas Klein, Kathrin J. Mohler, Matthias Eibl, Wolfgang Wieser, Robert Huber, Siegfried Priglinger, and Armin Wolf,
Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm, Graefes Arch Clin Exp Ophthalmol , vol. 256, no. 2, pp. 289-298, Dez. 2018.
DOI:10.1007/s00417-017-3857-9
Bibtex: BibTeX
@article{Maertz2018,
   author = {Maertz, J; Kolb, J P; Klein, T; Mohler, K J; Eibl, M; Wieser, W; Huber, R; Priglinger, S and Wolf, A},
   title = {Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   number = {2},
   pages = {289-298},
   DOI = {10.1007/s00417-017-3857-9},
   url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032262413&doi=10.1007%2fs00417-017-3857-9&partnerID=40&md5=a46c315f12cf5e633ea0f7e644116eb3},
   year = {2018},
   Keywords= {En face imaging, Optical coherence tomography, Swept-source OCT, Megahertz OCT, 3D rendering, Optic disc, Optic disc pit, Optic disc pit maculopathy, AG-Huber_OCT},
   type = {Journal Article}
}
Tom Pfeiffer, Markus Petermann, Wolfgang Draxinger, Christian Jirauschek, and Robert Huber,
Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography, Biomed. Opt. Express , vol. 9, no. 9, pp. 4130-4148, 09 2018. Optica Publishing Group.
DOI:10.1364/BOE.9.004130
Bibtex: BibTeX
@article{Pfeiffer:18,
author = {Tom Pfeiffer and Markus Petermann and Wolfgang Draxinger and Christian Jirauschek and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Fiber optics imaging; Lasers, fiber; Optical coherence tomography; Laser stabilization ; Lasers, frequency modulated ; Analog to digital converters; Dark solitons; Image quality; Laser modes; Mode locking; Optical coherence tomography},
number = {9},
pages = {4130--4148},
publisher = {Optica Publishing Group},
title = {Ultra low noise Fourier domain mode locked laser for high quality megahertz optical coherence tomography},
volume = {9},
month = {Sep},
year = {2018},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-9-9-4130},
doi = {10.1364/BOE.9.004130},
abstract = {We investigate the origin of high frequency noise in Fourier domain mode locked (FDML) lasers and present an extremely well dispersion compensated setup which virtually eliminates intensity noise and dramatically improves coherence properties. We show optical coherence tomography (OCT) imaging at 3.2 MHz A-scan rate and demonstrate the positive impact of the described improvements on the image quality. Especially in highly scattering samples, at specular reflections and for strong signals at large depth, the noise in optical coherence tomography images is significantly reduced. We also describe a simple model that suggests a passive physical stabilizing mechanism that leads to an automatic compensation of remaining cavity dispersion in FDML lasers.},
}
Hinnerk Schulz-Hildebrandt, Tom Pfeiffer, Tim Eixmann, Sabrina Lohmann, Martin Ahrens, Josua Rehra, Wolfgang Draxinger, Peter König, Robert Huber, and Gereon Hüttmann,
High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography, Opt. Lett. , vol. 43, no. 18, pp. 4386-4389, 09 2018. Optica Publishing Group.
DOI:10.1364/OL.43.004386
Bibtex: BibTeX
@article{Schulz-Hildebrandt:18,
author = {Hinnerk Schulz-Hildebrandt and Tom Pfeiffer and Tim Eixmann and Sabrina Lohmann and Martin Ahrens and Joshua Rehra and Wolfgang Draxinger and Peter K\"{o}nig and Robert Huber and Gereon H\"{u}ttmann},
journal = {Opt. Lett.},
keywords = {Fiber optics imaging; Endoscopic imaging; Medical and biological imaging; Optical coherence tomography; Fourier domain mode locking; Image quality; Optical coherence tomography; Single mode fibers; Step index fibers; Three dimensional imaging},
number = {18},
pages = {4386--4389},
publisher = {Optica Publishing Group},
title = {High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography},
volume = {43},
month = {Sep},
year = {2018},
url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-43-18-4386},
doi = {10.1364/OL.43.004386},
abstract = {We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 $\mu$m was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in spirals for scanning the sample, the beam quality remains constant over the entire field of view with a diameter of 0.8 mm. The scanning frequency was adjusted to 1.22 kHz for use with a 3.28 MHz Fourier domain mode locked OCT system. Densely sampled volumes have been imaged at a rate of 6 volumes per second.},
}
Mark Schmidt, Tom Pfeiffer, Christin Grill, Robert Huber, and Christian Jirauschek,
Self-Stabilization Mechanism in Fourier Domain Mode-Locked (FDML) Lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2018. Optica Publishing Group.
DOI:10.1364/OSAC.389972
Bibtex: BibTeX
@article{Schmidt:20,
author = {Mark Schmidt and Tom Pfeiffer and Christin Grill and Robert Huber and Christian Jirauschek},
journal = {OSA Continuum},
keywords = {Doppler effect; Laser modes; Laser sources; Nonlinear effects; Stimulated Raman scattering; Vertical cavity surface emitting lasers},
number = {6},
pages = {1589--1607},
publisher = {Optica Publishing Group},
title = {Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers},
volume = {3},
month = {Jun},
year = {2020},
url = {https://opg.optica.org/osac/abstract.cfm?URI=osac-3-6-1589},
doi = {10.1364/OSAC.389972},
abstract = {Understanding the dynamics of Fourier domain mode-locked (FDML) lasers is crucial for determining physical coherence limits, and for finding new superior methods for experimental realization. In addition, the rich interplay of linear and nonlinear effects in a laser ring system is of great theoretical interest. Here we investigate the dynamics of a highly dispersion-compensated setup, where over a bandwidth of more than 100\&\#x2009;nm, a highly coherent output with nearly shot-noise-limited intensity fluctuations was experimentally demonstrated. This output is called the sweet-spot. We show by numerical simulation that a finite amount of residual dispersion in the fiber delay cavity of FDML lasers can be compensated by the group delay dispersion in the swept bandpass filter, such that the intensity trace exhibits no dips or high-frequency distortions, which are the main source of noise in the laser. In the same way, a small detuning from the ideal sweep filter frequency can be tolerated. Furthermore, we find that the filter\&\#x2019;s group delay dispersion improves the coherence properties of the laser, and acts as a self-stabilizing element in the cavity. Our theoretical model is validated against experimental data, showing that all relevant physical effects for the sweet-spot operating regime are included.},
}
P Schulz-Hildebrandt, and G H\"{u}ttmann,
Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations, in 2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources , 2018. pp. 105910O.
DOI:10.1117/12.2303755
ISBN:9781510616745
Bibtex: BibTeX
@inproceedings{Schulz-Hildebrandt2018a,
title = {Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations},
author = {Schulz-Hildebrandt,H; M\"{u}nter, M; Ahrens,M; Spahr, H; Hillmann, D; K\"{o}nig, P and  H\"{u}ttmann, G},
doi = {10.1117/12.2303755},
isbn = {9781510616745},
year = {2018},
date = {2018-03-05},
booktitle = {2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources},
volume = {10591},
pages = {105910O},
abstract = {Optical coherence tomography (OCT) images scattering tissues with 5 to 15 μm resolution. This is usually not sufficient for a distinction of cellular and subcellular structures. Increasing axial and lateral resolution and compensation of artifacts caused by dispersion and aberrations is required to achieve cellular and subcellular resolution. This includes defocus which limit the usable depth of field at high lateral resolution. OCT gives access the phase of the scattered light and hence correction of dispersion and aberrations is possible by numerical algorithms. Here we present a unified dispersion/aberration correction which is based on a polynomial parameterization of the phase error and an optimization of the image quality using Shannon’s entropy. For validation, a supercontinuum light sources and a costume-made spectrometer with 400 nm bandwidth were combined with a high NA microscope objective in a setup for tissue and small animal imaging. Using this setup and computation corrections, volumetric imaging at 1.5 μm resolution is possible. Cellular and near cellular resolution is demonstrated in porcine cornea and the drosophila larva, when computational correction of dispersion and aberrations is used. Due to the excellent correction of the used microscope objective, defocus was the main contribution to the aberrations. In addition, higher aberrations caused by the sample itself were successfully corrected. Dispersion and aberrations are closely related artifacts in microscopic OCT imaging. Hence they can be corrected in the same way by optimization of the image quality. This way microscopic resolution is easily achieved in OCT imaging of static biological tissues.},
keywords = {OCM},
pubstate = {published},
tppubtype = {inproceedings}
}

Wavelength agile multi-photon microscopy with a fiber amplified diode laser, Biomedical Optics Express , vol. 9, no. 12, pp. 6273--6282, 2018.
DOI:10.1364/BOE.9.006273
Bibtex: BibTeX
@article{Eibl2018,
author = {Matthias Eibl, Daniel Weng, Hubertus Hakert, Jan Philip Kolb, Tom Pfeiffer, Jennifer E. Hundt, Robert Huber and Sebastian Karpf},
title = {Wavelength agile multi-photon microscopy with a fiber amplified diode laser},
journal = {Biomedical Optics Express},
keywords = {NLI, TPEF, Multiphoton},
volume = {9},
number = {12},
pages = {6273--6282},
doi = {10.1364/BOE.9.006273},
year = {2018}
}
Yoko Miura,
Two-Photon Microscopy (TPM) and Fluorescence Lifetime Imaging Microscopy (FLIM) of Retinal Pigment Epithelium (RPE) of Mice In Vivo, in Mouse Retinal Phenotyping: Methods and Protocols , Tanimoto, Naoyuki, Eds. Springer New York, 2018, pp. 73-88.
ISBN:978-1-4939-7720-8
Datei: 978-1-4939-7720-8_5
Bibtex: BibTeX
@inbook{Miura2018,
   author = {Miura, Y},
   title = {Two-Photon Microscopy (TPM) and Fluorescence Lifetime Imaging Microscopy (FLIM) of Retinal Pigment Epithelium (RPE) of Mice In Vivo},
   booktitle = {Mouse Retinal Phenotyping: Methods and Protocols},
   editor = {Tanimoto, Naoyuki},
   publisher = {Springer New York},
  
   pages = {73-88},
   ISBN = {978-1-4939-7720-8},
   url={https://doi.org/10.1007/978-1-4939-7720-8_5},
   year = {2018},
   type = {Book Section}
}
Robert Wang, and Gijs van Soest,
Thermo-elastic optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII , International Society for Optics and Photonics, 2018. pp. 108672C.
Bibtex: BibTeX
@inproceedings{Wang2019-1,
   author = {Wang, Tianshi;Pfeiffer, Tom;Wieser, Wolfgang;van Beusekom, Heleen;Draxinger, Wolfgang;van der Steen, Antonius FW;Huber, Robert and van Soest, Gijs},
   title = {Thermo-elastic optical coherence tomography},
   booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII},
   publisher = {International Society for Optics and Photonics},
   volume = {10867},
   pages = {108672C},
   type = {Conference Proceedings}
}
R Tode, and J Roider,
Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models, Transl Vis Sci Technol , vol. 7, no. 3, pp. 2, 2018.
DOI:10.1167/tvst.7.3.2
Datei: 29736323
Bibtex: BibTeX
@article{Tode2018,
   author = {Tode, J; Richert, E; Koinzer, S; Klettner, A; von der Burchard, C; Brinkmann, R; Lucius, R and Roider, J},
   title = {Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models},
   journal = {Transl Vis Sci Technol},
  
   pages = {2},
   ISSN = {2164-2591 (Print)
2164-2591 (Linking)}, 
   url = {https://www.ncbi.nlm.nih.gov/pubmed/29736323},
   year = {2018},
   type = {Journal Article}
}
Christian Herzog, Benedikt Schmarbeck, Ole Thomsen, Marlin Siebert, and Ralf Brinkmann,
Temperature-controlled laser therapy of the retina via robust adaptive Ɦ∞-control., .... De Gruyter, 2018.
Datei: auto-2018-0066
Bibtex: BibTeX
   @book{Brinkmann2018/2,
   author = {Herzog, C;Thompson, O; Schmarbeck, B; Siebert, M and Brinkmann, R},
   title = {Temperature-controlled laser therapy of the retina via robust adaptive Ɦ∞-control},
   publisher = {De Gruyter},
   
   journal = {at-Automatisierungstechnik},
   pages = {1051-1063},   
   year = {2018},
   type = {Book},
  URL = {https://doi.org/10.1515/auto-2018-0066},
   
  
keywords = {Laser therapy; robust control; parameter estimation; photoacoustics; real-time temperature determination},
   abstract = {Recent studies demonstrate therapeutic benefits in retinal laser therapy even for non-visible effects of the irradiation. However, in practice, ophthalmologists often rely on the visual inspection of irradiation sites to manually set the laser power for subsequent ones. Since absorption properties vary strongly between sites, this procedure can lead to under- or over-treatment. To achieve safe automatic retinal laser therapy, this article proposes a robust control scheme based on photoacoustic feedback of the retinal temperature increase. The control scheme is further extended to adapt to real-time parameter estimates and associated bounds on the uncertainty of each irradiation site. Both approaches are successfully validated in ex vivo experiments on pigs’ eyes, achieving consistent irradiation durations of 55 ms despite the uncertainty in absorption properties.}
}
J Rudnitzki, and G Huettmann,
siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase, Journal of BIOPHOTONICS , 2018.
DOI:10.1002/jbio.201700329
Bibtex: BibTeX
@article{Rahmanzadeh2018,
   author = {Rudnitzki, F; Feineis, S; Rahmanzadeh, R; Endl, E; Lutz, J; Groll, J and Huettmann, G},
   title = {siRNA release from gold nanoparticles by nanosecond pulsed
laser irradiation and analysis of the involved temperature
increase},
   journal = {Journal of BIOPHOTONICS},
  doi = {10.1002/jbio.201700329},
   

keywords = {cavitation|cell manipulation|controlled release|gold nanoparticle bio-conjugates|laser nanoeffects},
abstract = {Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particle and near the surface were calculated for the different radiant exposures. Upon irradiation with laser pulses of 4 nanosecond duration release started for both particle sizes at a calculated temperature increase of approximately 500 K. Maximum coumarin release was observed for 15 nm particles after irradiation with radiant exposure of 80 mJ cm−2 and with 32 mJ cm−2 for 30 nm particles. This corresponds to a temperature increase of 815 and 900 K, respectively. Our results show that the molecular release by nanosecond pulsed irradiation is based on a different mechanism compared to continuous or femtosecond irradiation. Local temperatures are considerably higher and it is expected that bubble formation plays a crucial role in release and damage to cellular structures. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim},
   year = {2018},
   type = {Journal Article}
}
D Borghesan, and E Vander Poorten,
Single Scan OCT-based Retina Detection for Robot-assisted Retinal Vein Cannulation, J Med Robot Res , pp. 184005, 2018.
DOI:10.1142/S2424905X18400056
Datei: S2424905X18400056
Bibtex: BibTeX
@article{borghesan2018single,
title = {Single Scan OCT-based Retina Detection for Robot-assisted Retinal Vein Cannulation},
author = {Borghesan,G; Ourak,M; Lankenau, E; H\"{u}ttmann,G; Schulz-Hildebrandt,H; Willekens,K; Stalmans, K; Reynaerts, D and Vander Poorten,E},
editor = {World Scientific},
url = {https://www.worldscientific.com/doi/abs/10.1142/S2424905X18400056},
doi = {10.1142/S2424905X18400056},
year = {2018},
date = {2018-02-12},
journal = {J Med Robot Res},

pages = {184005},
abstract = {Vitreoretinal surgery concerns a set of particularly demanding minimal invasive micro-surgical interventions at the retina. Micro-surgeons are targeting sub-millimeter-sized structures here. Tiny vessels or wafer-thin membranes are to be cannulated or need to be peeled off. The greatest care is to be displayed not to damage these fragile structures or to inadvertently injure the underlying retina. Damage to the latter is mostly irreparable and might cause permanent loss of vision. Despite the availability over excellent stereo microscopes, wide-angle lenses and powerful light source visualization remains a problem. Especially, the limited depth perception is still perceived as a major bottle-neck whereas efforts have been conducted to integrate sensing capability in today’s state-of-the-art instruments, so far, little effort has been paid to process the obtained sensor data and turns this into a reliable source of information upon which robot assistive guidance schemes could be endowed upon. This paper proposes a number of processing techniques tailored to Optical Coherence Tomography (OCT) measurements. The first results of the proposed algorithms show that it is feasible to extract good and reliable distance estimates from this otherwise rather noisy signal and from a fairly limited dataset. The used data are the so-called A-scans. These are OCT measurements consisting of a single-line image that could be captured by an instrument-mounted fiber through which the OCT signal passes back-and-forth. However, in this work, we perform a pilot study whereby the employed A-scans are extracted from B-scans that are captured by a microscope-mounted OCT scanner, rather than obtained from a probe. The performance of a first embodiment of the algorithm that is based on an Unscented Kalman Filter (UKF) is compared to the performance of a second embodiment that relies on a Particle Filter (PF), focusing on the issues in filter initialization and the tracking quality. Finally, results of UKF and PF executions on a validation dataset are presented. 
Read More: https://www.worldscientific.com/doi/abs/10.1142/S2424905X18400056},
keywords = {Endoskope},
pubstate = {published},
tppubtype = {article}
}
R Sudkamp,
Simple approach for aberration-corrected OCT imaging of the human retina, Opt Lett , pp. 4224, 2018.
DOI:10.1364/ol.43.004224
Bibtex: BibTeX
@article{Sudkamp2018a,
   author = {Sudkamp, H; Hillmann, D; Koch, P;vom Endt, M; Spahr, H; Münst, M; Pfäffle, C; Birngruber, R and Hüttmann, G},
   title = {Simple approach for aberration-corrected OCT imaging of the human retina},
   journal = {Opt Lett},
   
   pages = {4224},
   ISSN = {0146-9592
1539-4794},
   DOI = {10.1364/ol.43.004224},
   year = {2018},
   type = {Journal Article},
   keyword = {Retome}
}
R Seifert,
Selective retina therapy: toward an optically controlled automatic dosing, J Biomed Opt , pp. 1-12, 2018.
DOI:10.1117/1.JBO.23.11.115002
Bibtex: BibTeX
@article{seifert2018,
   author = {Seifert, E; Tode, J; Pielen, A; Theisen-Kunde, D; Framme, C; Roider, J; Miura, Y; Birngruber, R and Brinkmann, R},
   title = {Selective retina therapy: toward an optically controlled automatic dosing},
   journal = {J Biomed Opt},
   
   pages = {1-12},
   ISSN = {1560-2281 (Electronic)
1083-3668 (Linking)},
   DOI = {10.1117/1.JBO.23.11.115002},   
keywords = {algorithm, lasers in medicine, ophthalmology, retinal pigment epithelium, selective retina therapy, selectivity},
   year = {2018},
   type = {Journal Article}
}
D Casper, and G H\"{u}ttmann,
Optimized segmentation and characterization of capillary networks using OCT (Conference Presentation), in Proc. SPIE 10467, Photonics in Dermatology and Plastic Surgery 2018 , 2018.
DOI:10.1117/12.2292005
Datei: 12.2292005
Bibtex: BibTeX
@conference{Casper2018,
title = {Optimized segmentation and characterization of capillary networks using OCT (Conference Presentation)},
author = {Casper, M; Schulz-Hildebrandt, H; Evers, M; Birngruber, R; Manstein, D and H\"{u}ttmann, G },
url = {https://doi.org/10.1117/12.2292005},
doi = {10.1117/12.2292005},
year = {2018},
date = {2018-03-14},
booktitle = {Proc. SPIE 10467, Photonics in Dermatology and Plastic Surgery 2018},
journal = {Proc.SPIE},

abstract = {The ability to image the physiology of microvasculature with high spatial resolution in three dimensions while investigating structural changes of skin, is essential for understanding the complex processes of skin aging, wound healing and disease development. Further, the quantitative, automatic assessment of these changes enables to analyze large amounts of image data in an abstract but comprehensive manner. 
However, previous work using OCT with methods of angiography was imaging less scattering, hence more challenging tissue than skin, such as brain and retina tissue. The published methods for capillary segmentation were mostly non-automatic, poorly benchmarked against state-of-the-art methods of computer vision and not applied to investigate medical processes and studies in a comprehensive fashion. 
Here, segmentation of capillaries in skin is reported and its efficacy is demonstrated in both, a 
longitudinal mouse study and a preliminary study in humans. By combining state-of-the-art image 
processing methods in an optimized way, we were able to improve the segmentation results and analyze the impact of each post-processing step. 
Furthermore, this automatic segmentation enabled us to analyze big amounts of 
datasets automatically and derive meaningful conclusions for the planning of clinical studies. 
With this work, optical coherence tomography is combined with methods of computer vision to a diagnostic 
tool with unique capabilities to characterize vascular diversity and provide extraordinary 
opportunities for dermatological investigation in both, clinics and research.},
keywords = {},
pubstate = {published},
tppubtype = {conference}
}
Elisabeth Richert, Stefan Koinzer, Jan Tode, Kerstin Schlott, Ralf Brinkmann, Jost Hillenkamp, Alexa Klettner, and Johann Roider,
Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy, Investigative Ophthalmology & Visual Science , pp. 1323-1331, 2018.
DOI:10.1167/iovs.17-23163
Datei: iovs.17-23163
Bibtex: BibTeX
@article{Brinkmann2018,
   author = {Richert, E; Koinzer, S; Tode, J; Schlott, K; Brinkmann, R; Hillenkamp, J; Klettner, A and Roider, J},
   title = {Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy},
   journal = {Investigative Ophthalmology & Visual Science},
   
   pages = {1323-1331},
   ISSN = {1552-5783},
  
   url = {http://dx.doi.org/10.1167/iovs.17-23163},
   year = {2018},
   type = {Journal Article}
}
P Schulz-Hildebrandt, and Gereon Hüttmann,
Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography, Biomedical Optics Express , pp. 636-647, 2018.
DOI:10.1364/BOE.9.000636
ISBN:10.1364/BOE.9.000636
Datei: abstract.cfm
Bibtex: BibTeX
@article{schulz2018novel,
title = {Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography},
author = {Schulz-Hildebrandt, H; Pieper, M; Stehmar,C; Ahrens, M; Idel, C; Wollenberg,B; K\"{o}nig,P and Gereon H\"{u}ttmann},
editor = {Optic Socie Amer},
url = {https://www.osapublishing.org/abstract.cfm?URI=boe-9-2-636
https://www.osapublishing.org/boe/viewmedia.cfm?uri=boe-9-2-636&seq=0},
doi = {10.1364/BOE.9.000636},
isbn = {10.1364/BOE.9.000636},
year = {2018},
date = {2018-01-16},
journal = {Biomedical Optics Express},

pages = {636-647},
abstract = {Intravital microscopy (IVM) offers the opportunity to visualize static and dynamic changes of tissue on a cellular level. It is a valuable tool in research and may considerably improve clinical diagnosis. In contrast to confocal and non-linear microscopy, optical coherence tomography (OCT) with microscopic resolution (mOCT) provides intrinsically cross-sectional imaging. Changing focus position is not needed, which simplifies especially endoscopic imaging. For in-vivo imaging, here we are presenting endo-microscopic OCT (emOCT). A graded-index-lens (GRIN) based 2.75 mm outer diameter rigid endoscope is providing 1.5 \textendash 2 μm nearly isotropic resolution over an extended field of depth. Spherical and chromatic aberrations are used to elongate the focus length. Simulation of the OCT image formation, suggests overall a better image quality in this range compared to a focused Gaussian beam. Total imaging depth at a reduced sensitivity and lateral resolution is more than 200 μm. Using a frame rate of 80 Hz cross-sectional images of concha nasalis were demonstrated in humans, which could resolve cilial motion, cellular structures of the epithelium, vessels and blood cells. Mucus transport velocity was determined successfully. The endoscope may be used for diagnosis and treatment control of different lung diseases like cystic fibrosis or primary ciliary dyskinesia, which manifest already at the nasal mucosa.},
keywords = {Endoskope, OCM},
pubstate = {published},
tppubtype = {article}
}
Robert Wang, and Gijs van Soest,
Megahertz intravascular Doppler optical coherence tomography enables simultaneous morphological and flow pattern imaging, in Diagnostic and Therapeutic Applications of Light in Cardiology 2019 , International Society for Optics and Photonics, 2018. pp. 1085503.
Bibtex: BibTeX
@inproceedings{Wang2019-3,
   author = {Wang, Tianshi;Pfeiffer, Tom;Daemen, Joost;Mastik, Frits;Wieser, Wolfgang;van der Steen, AFW;Huber, Robert and van Soest, Gijs},
   title = {Megahertz intravascular Doppler optical coherence tomography enables simultaneous morphological and flow pattern imaging},
   booktitle = {Diagnostic and Therapeutic Applications of Light in Cardiology 2019},
   publisher = {International Society for Optics and Photonics},
   volume = {10855},
   pages = {1085503},
   type = {Conference Proceedings}
}
Ralph Hakert,
Label-free imaging of tumorous tissue in the Raman fingerprint region with time-encoded (TICO) stimulated Raman scattering (Conference Presentation), in Multiphoton Microscopy in the Biomedical Sciences XIX , International Society for Optics and Photonics, 2018. pp. 108821R.
Bibtex: BibTeX
@inproceedings{Hakert2019,
   author = {Hakert, Hubertus;Eibl, Matthias;Karpf, Sebastian;Wollenberg, Barbara;Pries, Ralph and Huber, Robert},
   title = {Label-free imaging of tumorous tissue in the Raman fingerprint region with time-encoded (TICO) stimulated Raman scattering (Conference Presentation)},
   booktitle = {Multiphoton Microscopy in the Biomedical Sciences XIX},
   publisher = {International Society for Optics and Photonics},
   volume = {10882},
   pages = {108821R},
   type = {Conference Proceedings}
}
D. Spahr,
Interferometric detection of 3D motion using computational subapertures in optical coherence tomography, Opt Expr , pp. 18803--18816, 2018. OSA.
Datei: OE.26.018803
Bibtex: BibTeX
@article{Spahr:18,
author = { Spahr, H; Pfäffle, C; Koch,C; Sudkamp, H; Hüttmann, G und Hillmann, D},
journal = {Opt Expr},
keywords = {Funktion, Fullfield},

pages = {18803--18816},
publisher = {OSA},
title = {Interferometric detection of 3D motion using computational subapertures in optical coherence tomography},


year = {2018},
url = {https://doi.org/10.1364/OE.26.018803},

abstract = {Doppler optical coherence tomography (OCT) quantifies axial motion with high precision, whereas lateral motion cannot be detected by a mere evaluation of phase changes. This problem was solved by the introduction of three-beam Doppler OCT, which, however, entails a high experimental effort. Here, we present the numerical analogue to this experimental approach. Phase-stable complex-valued OCT datasets, recorded with full-field swept-source OCT, are filtered in the Fourier domain to limit imaging to different computational subapertures. These are used to calculate all three components of the motion vector with interferometric precision. As known from conventional Doppler OCT for axial motion only, the achievable accuracy exceeds the actual imaging resolution by orders of magnitude in all three dimensions. The feasibility of this method is first demonstrated by quantifying micro-rotation of a scattering sample. Subsequently, a potential application is explored by recording the 3D motion vector field of tissue during laser photocoagulation in ex-vivo porcine retina.},
}

Jan Philip Kolb, Tom Pfeiffer, Matthias Eibl, Hubertus Hakert, and Robert Huber,
High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates, Biomed. Opt. Express , vol. 9, no. 1, pp. 120-130, 01 2018. Optica Publishing Group.
DOI:10.1364/BOE.9.000120
Bibtex: BibTeX
@article{Kolb:18,
author = {Jan Philip Kolb and Tom Pfeiffer and Matthias Eibl and Hubertus Hakert and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {Medical optics instrumentation; Lasers, fiber; Medical and biological imaging; Ophthalmic optics and devices ; Optical coherence tomography; Adaptive optics; Image quality; In vivo imaging; Mode locking; Ophthalmic imaging; Three dimensional imaging},
number = {1},
pages = {120--130},
publisher = {Optica Publishing Group},
title = {High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates},
volume = {9},
month = {Jan},
year = {2018},
url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-9-1-120},
doi = {10.1364/BOE.9.000120},
abstract = {We present a new 1060 nm Fourier domain mode locked laser (FDML laser) with a record 143 nm sweep bandwidth at 2\&\#x2219;\&\#x202F;417 kHz\&\#x202F; $=$ \&\#x202F;834 kHz and 120 nm at 1.67 MHz, respectively. We show that not only the bandwidth alone, but also the shape of the spectrum is critical for the resulting axial resolution, because of the specific wavelength-dependent absorption of the vitreous. The theoretical limit of our setup lies at 5.9 \&\#x00B5;m axial resolution. In vivo MHz-OCT imaging of human retina is performed and the image quality is compared to the previous results acquired with 70 nm sweep range, as well as to existing spectral domain OCT data with 2.1 \&\#x00B5;m axial resolution from literature. We identify benefits of the higher resolution, for example the improved visualization of small blood vessels in the retina besides several others.},
}
Gijs Cecchetti,
Heartbeat optical coherence tomography enables accurate in vivo stents imaging: a quantitative image processing study (Conference Presentation), in Diagnostic and Therapeutic Applications of Light in Cardiology 2019 , International Society for Optics and Photonics, 2018. pp. 1085506.
Bibtex: BibTeX
@inproceedings{Cecchetti2019,
   author = {Cecchetti, Leonardo;Wang, Tianshi;Pfeiffer, Tom;Wieser, Wolfgang;van der Steen, Antonius FW;Huber, Robert;van Soest, Gijs and Huber, Robert Alexander},
   title = {Heartbeat optical coherence tomography enables accurate in vivo stents imaging: a quantitative image processing study (Conference Presentation)},
   booktitle = {Diagnostic and Therapeutic Applications of Light in Cardiology 2019},
   publisher = {International Society for Optics and Photonics},
   volume = {10855},
   pages = {1085506},
   type = {Conference Proceedings}
}
Katharina Kern, Carla Lotta Mertineit, Ralf Brinkmann, and Yoko Miura,
Expression of heat shock protein 70 and cell death kinetics after different thermal impacts on cultured retinal pigment epithelial cells, Exp Eye Res , pp. 117-126, 2018.
DOI:10.1016/j.exer.2018.02.013
Bibtex: BibTeX
@article{Miura2018,
   author = {Kern, K; Mertineit, C L; Brinkmann, R and Miura, Y},
   title = {Expression of heat shock protein 70 and cell death kinetics after different thermal impacts on cultured retinal pigment epithelial cells},
   journal = {Exp Eye Res},
  
   pages = {117-126},
   ISSN = {1096-0007 (Electronic)
0014-4835 (Linking)},
   DOI = {10.1016/j.exer.2018.02.013},
   year = {2018},
   type = {Journal Article}
}
C L Evers, and D Manstein,
Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM, Scientific Reports , 2018.
DOI:10.1038/s41598-018-27093-x
Bibtex: BibTeX
@article{Evers2018,
   author = {Evers, M ;Salma, N; Osseiran, S; Casper, M; Birngruber, R; Evans, C L and Manstein, D},
   title = {Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM},
   journal = {Scientific Reports},
   
   DOI = {10.1038/s41598-018-27093-x},
   
   year = {2018},
   type = {Journal Article}
}
D Smits, and E.B Vander Poorten,
Development and Experimental Validation of a Combined FBG Force and OCT Distance Sensing Needle for Robot-Assisted Retinal Vein Cannulation, 2018. pp. 129-134.
DOI:10.1109/ICRA.2018.8460983
Bibtex: BibTeX
@inproceedings{Smits2018,
title = {Development and Experimental Validation of a Combined FBG Force and OCT Distance Sensing Needle for Robot-Assisted Retinal Vein Cannulation},
author = {Smits, J; Ourak, M; Gijbels, A;  Esteveny, L; Borghesan, G; Schoevaerdts, L; Willekens; Stalmans, P; Lankenau, E; Schulz-Hildebrandt, H; H\"{u}ttmann, G; Reynaerts, D and  Vander Poorten, E.B},

doi = {10.1109/ICRA.2018.8460983},
year = {2018},
date = {2018-09-20},
journal = {2018 IEEE Intern Conf Robot a Automation (ICRA)},
pages = {129-134},
abstract = {Retinal Vein Occlusion is a common retinal vascular disorder which can cause severe loss of vision. Retinal vein cannulation followed by injection of an anti-coagulant into the affected vein is a promising treatment. However, given the scale and fragility of the surgical workfield, this procedure is considered too high-risk to perform manually. A first successful robot-assisted procedure has been demonstrated. Even though successful, the procedure remains extremely challenging. This paper aims at providing a solution for the limited perception of instrument-tissue interaction forces as well as depth estimation during retinal vein cannulation. The development of a novel combined force and distance sensing cannulation needle relying on Fiber Bragg grating (FBG) and Optical Coherence Tomography (OCT) A-scan technology is reported. The design, the manufacturing process, the calibration method, and the experimental characterization of the produced sensor are discussed. 
The functionality of the combined sensing modalities and the real-time distance estimation algorithm are validated respectively on in-vitro and ex-vivo models.},
keywords = {Endoskope},
pubstate = {published},
tppubtype = {inproceedings}
}
F Strauch, and H. P Urbach,
Creation of aspheric interfaces on an electrowetting liquid lens using surface oscillations, AIP Advances , 2018.
DOI:10.1063/1.5063994
Bibtex: BibTeX
@article{Strauch2018,
   author = {Strauch, M;Somers, P A. A. M.;Bociort, F and Urbach, H. P},
   title = {Creation of aspheric interfaces on an electrowetting liquid lens using surface oscillations},
   journal = {AIP Advances},
   
   ISSN = {2158-3226},
   DOI = {10.1063/1.5063994},
   year = {2018},
   type = {Journal Article}
}
Tae Kwann Park, Juhye Choi, Young Shin Kim, Jina Kim, Ralf Brinkmann, Jungmook Lyu, and Jung Woo Han,
Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes, Graefe's Archive for Clinical and Experimental Ophthalmology , pp. 341-353, 2018.
Datei: s00417-017-3883-7
Bibtex: BibTeX
@article{Brinkmann2018,
   author = {Han, J W; Choi, J; Kim, Y S, Kim, J; Brinkmann, R; Lyu, J and Park, T K},
   title = {Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   
   pages = {341-353},
 
URL= {https://doi.org/10.1007/s00417-017-3883-7},
   year = {2018},
   type = {Journal Article}
}
R Uzunbajakava, and A Vogel,
Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions, in Progress in Biomedical Optics and Imaging - Proceedings of SPIE , 2018.
DOI:10.1117/12.2307804
Bibtex: BibTeX
@inproceedings{Vogel2018,
   author = {Uzunbajakava, N E; Varghese, B; Botchkareva, N V; Verhagen, R and Vogel, A},
   title = {Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions},
   booktitle = {Progress in Biomedical Optics and Imaging - Proceedings of SPIE},
   volume = {10492} ,
   DOI = {10.1117/12.2307804},
   year = {2018},
date = {2018-20-02},
   type = {Conference Proceedings},
year = { 2018}
}