Madita Göb

Doktorandin / PhD Student


Universität zu Lübeck
Institut für Biomedizinische Optik

Maria-Goeppert-Str. 1
23562 Lübeck
Gebäude MFC 1, Raum 2.24

Email:
Phone:
+49 451 3101 3234
Fax:
+49 451 3101 3233



Publikationen

2022

  • M. Göb, S. Burhan, S. Lotz and R. Huber: Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT. in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, no. 11948, pp. 27 - 31, SPIE, 2022
    BibTeX Link
    @inproceedings{Goeb2022BiOS,
    author = {M. Göb, S. Burhan, S. Lotz and R. Huber},
    title = {{Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT}},
    volume = {11948},
    booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI},
    editor = {Joseph A. Izatt and James G. Fujimoto},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {27 -- 31},
    keywords = {AG-Huber_FDML, AG-Huber_OCT, Optical Coherence Tomography, Fourier Domain Mode Locking, FDML, Optical Coherence Angiography, OCTA, Medical optics and biotechnology, Medical imaging, Three-dimensional image acquisition, Scanners, Microscopy},
    year = {2022},
    doi = {10.1117/12.2612171},
    }
  • M. Göb, T. Pfeiffer, W. Draxinger, S. Lotz, J.P. Kolb and R. Huber: Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence. Biomed. Opt. Express, no. 13, pp. 713-727, OSA, Feb, 2022
    BibTeX Link
    @article{Goeb2022,
    author = {M. G\"{o}b, T. Pfeiffer,  W. Draxinger, S. Lotz, J.P. Kolb and R. Huber},
    journal = {Biomed. Opt. Express},
    keywords = {AG-Huber_OCT;AG-Huber_FDML; High speed imaging; Image processing; Image quality; In vivo imaging; Range imaging; Vertical cavity surface emitting lasers},
    number = {2},
    pages = {713--727},
    publisher = {OSA},
    title = {Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence},
    volume = {13},
    month = {Feb},
    year = {2022},
    doi = {10.1364/BOE.448353},
    abstract = {We present continuous three-dimensional spectral zooming in live 4D-OCT using a home-built FDML based OCT system with 3.28 MHz A-scan rate. Improved coherence characteristics of the FDML laser allow for imaging ranges up to 10 cm. For the axial spectral zoom feature, we switch between high resolution and long imaging range by adjusting the sweep range of our laser. We present a new imaging setup allowing for synchronized adjustments of the imaging range and lateral field of view during live OCT imaging. For this, a novel inline recalibration algorithm was implemented that enables numerical k-linearization of the raw OCT fringes for every frame instead of every volume. This is realized by acquiring recalibration data within the dead time of the raster scan at the turning points of the fast axis scanner. We demonstrate in vivo OCT images of fingers and hands at different resolution modes and show real three-dimensional zooming during live 4D-OCT. A three-dimensional spectral zooming feature for live 4D-OCT is expected to be a useful tool for a wide range of biomedical, scientific and research applications, especially in OCT guided surgery.},
    }
    
    

2021

  • M. Göb, S. Burhan, W. Draxinger. J.P. Kolb and R. Huber: Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm^2/sec. European Conferences on Biomedical Optics 2021 (ECBO), pp. EW3C.4, Optical Society of America, 2021
    BibTeX Link
    @inproceedings{Goeb2021ECBO,
    author = {M. G\"{o}b, S. Burhan, W. Draxinger. J.P. Kolb and R. Huber},
    journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
    keywords = {AG-Huber_OCT},
    pages = {EW3C.4},
    publisher = {Optical Society of America},
    title = {Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm^2/sec},
    year = {2021},
    url = { https://opg.optica.org/abstract.cfm?uri=ecbo-2021-EW3C.4&origin=search},
    }
  • S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber: Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision. Biomedical Optics Express, no. 12(5), pp. 2604-2616, 2021
    BibTeX Link
    @article{Lotz2021,
       author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber},
       title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision},
       journal = {Biomedical Optics Express},
       volume = {12(5)},
       keywords={AG-Huber_FDML},
       pages = {2604-2616},
       url = {https://doi.org/10.1364/BOE.422898},
       year = {2021},
       type = {Journal Article}
    }
    
  • S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber: Characterization of the dynamics of an FDML laser during closed-loop cavity length control. in Fiber Lasers XVIII: Technology and Systems, no. 11665, pp. 236 - 241, SPIE, 2021
    BibTeX Link
    @inproceedings{LotzLASE2021,
    author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber},
    title = {{Characterization of the dynamics of an FDML laser during closed-loop cavity length control}},
    volume = {11665},
    booktitle = {Fiber Lasers XVIII: Technology and Systems},
    editor = {Michalis N. Zervas},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {236 -- 241},
    abstract = {In Fourier domain mode locked (FDML) lasers, extremely precise and stable matching of the filter tuning period and light circulation time in the cavity is essential for ultra-low noise operation. During the operation of FDML lasers, the ultra-low noise mode can be lost due to temperature drifts of the already temperature stabilized cavity resulting in increased intensity noise. Until now, the filter frequency is continuously regulated to match the changing light circulation time. However, this causes the filter frequency to constantly change by a few mHz and leads to synchronization issues in cases where a fixed filter frequency is desired. We present an actively cavity length controlled FDML laser and a robust and high precision feedback loop algorithm for maintaining ultra-low noise operation. Instead of adapting the filter frequency, the cavity length is adjusted by a motorized free space beam path to match the fixed filter frequency. The closed-loop system achieves a stability of ~0.18 mHz at a sweep repetition rate of ~418 kHz which corresponds to a ratio of 4×10<sup>-10</sup>. We investigate the coherence properties during the active cavity length adjustments and observe no noise increase compared to fixed cavity length. The cavity length control is fully functional and for the first time, offers the possibility to operate an FDML laser in sweet spot mode at a fixed frequency or phase locked to an external clock. This opens new possibilities for system integration of FDML lasers.},
    keywords = {AG-Huber_FDML, FDML, Fourier domain mode locking, laser beating, tunable laser, optical coherence tomography, OCT},
    year = {2021},
    URL = {hhttps://doi.org/10.1117/12.2578514}
    }

2020

  • T. Pfeiffer, M. Göb, W. Draxinger, S. Karpf, J.P. Kolb and R. Huber: Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging. Biomed. Opt. Express, no. 11, pp. 6799-6811, OSA, Nov, 2020
    BibTeX Link
    @article{Pfeiffer:20,
    author = {T. Pfeiffer, M. G\"{o}b, W. Draxinger, S. Karpf, J.P. Kolb and R. Huber},
    journal = {Biomed. Opt. Express},
    keywords = {AG-Huber_OCT; High speed imaging; Image quality; Optical coherence tomography; Swept lasers; Swept sources; Systems design},
    number = {11},
    pages = {6799--6811},
    publisher = {OSA},
    title = {Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging},
    volume = {11},
    month = {Nov},
    year = {2020},
    doi = {10.1364/BOE.402477},
    abstract = {In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze them point by point and describe the appropriate solutions. We prove that coherent averaging is possible at MHz OCT-speed without special interferometer designs or digital phase stabilization. We find, that in our system up to \&\#x223C;100x coherent averaging is possible while achieving a sensitivity increase close to the ideal values. This corresponds to a speed reduction from 3.3 MHz to 33 kHz and a sensitivity gain of 20 dB. We show an imaging comparison between coherent and magnitude averaging of a human finger knuckle joint in vivo with 121\&\#x00A0;dB sensitivity for the coherent case. Further, the benefits of computational downscaling in low sensitivity MHz-OCT systems are analyzed.},
    }
    

2019

  • Madita Göb,Tom Pfeiffer,Robert Huber: Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780Y, no. 11078, 2019
    BibTeX Link Datei
    @proceeding{Goeb2019,
    author = {Madita Göb,Tom Pfeiffer,Robert Huber},
    title = {Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy},
    volume = {11078},
    year = {2019},
    
    URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/110780Y/Towards-combined-optical-coherence-tomography-and-multi-spectral-imaging-with/10.1117/12.2526796.short},
    keywords = {AG-Huber_OCT},
    booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780Y},
    eprint = {}
    }