@article{Seifert2021,
   author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R},
   title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {62(3)},
  
   pages = {32-32},
   ISSN = {1552-5783},
   DOI = {10.1167/iovs.62.3.32},
   url = {https://doi.org/10.1167/iovs.62.3.32},
   year = {2021},
   type = {Journal Article}
}

@article{Büttner2021,
   author = {Büttner, M.;Luger, B.;Abou Moulig, W.;Junker, B.;Framme, C.;Jacobsen, C.;Knoll, K. and Pielen, A.; SRT Study Group(Brinkmann, R.; Miura, Y.)},
   title = {Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   volume = {259},
   number = {6},
   pages = {1401-1410},
   ISSN = {0721-832X (Print)
0721-832x},
   DOI = {10.1007/s00417-020-04999-9},
abstract = { PURPOSE: Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% within 6 months. In this study, the efficacy of selective retina therapy (SRT) was examined in patients with therapy refractory persistent acute CSC defined by symptoms for at least 6 months and persistent subretinal fluid (SRF) despite eplerenone therapy. MATERIAL AND METHODS: This is a prospective, monocentric observational study in 17 eyes (16 patients, mean age 42 years, 2 female). SRT was performed with the approved R:GEN laser (Lutronic, South Korea), a micropulsed 527-nm Nd:YLF laser device, with a train of 30 pulses of 1.7 μs at 100-Hz repetition rate at the point of focal leakage determined by fluorescein angiography (FA) at baseline (BSL). Visits on BSL, week 4 (wk4), and week 12 (wk12) included best corrected visual acuity (BCVA, logMar), central retinal thickness (CRT) on spectral domain optical coherence tomography (SD-OCT), and FA. Statistical analysis was performed by pair-by-pair comparisons of multiple observations in each case with Bonferroni correction for multiple testing. (IBM SPSS Statistics 25®). RESULTS: Mean CRT at BSL was 387.69 ± 110.4 μm. CRT significantly decreased by 106.31 μm in wk4 (95%-KI: 21.42-191.2; p = 0.01), by 133.63 μm in wk12 (95%-KI: 50.22-217.03; p = 0.001) and by 133.81 μm (95%-KI: 48.88-218.75; p = 0.001) compared to BSL. Treatment success defined as complete resolution of SRF occurred at wk4 in 7/17 eyes (35.3%) and at wk12 in 10/17 eyes (58.8%). Re-SRT was performed in 7/17 eyes (41.2%) after an average of 107.14 ± 96.59 days. Treatment success after Re-SRT was observed in 4/6 eyes (66.6%, 12 weeks after Re-SRT). Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. Notably, eyes with treatment success showed better BCVA at all timepoints and gained more letters compared to failures. CONCLUSION: Single or repetitive SRT may be an effective and safe treatment in 2 of 3 patients suffering from acute persistent CSC after 6 months of symptoms or more. We observed complete resolution of SRF in around 60% of eyes 12 weeks after first SRT treatment and also 12 weeks after Re-SRT treatment in eyes with persistent or recurrent SRF. Results on the long-term course after SRT are still pending.},
keywords = { Central serous chorioretinopathy; Fluorescein angiography; Micropulse laser; OCT; Persistent acute disease; Selective retina treatment; Subretinal fluid. },
   year = {2021},
   type = {Journal Article}
}

@article{Richert2021,
   title        = {Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy},
   author       = {Richert, E;Papenkort, J;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Framme, C;Roider, J and Tode, J},
   year         = 2021,
   journal      = {BMC Ophthalmology},
   volume       = {21(1)},
   pages        = 412,
   issn         = {1471-2415},
   url          = {https://doi.org/10.1186/s12886-021-02188-8},
   keywords     = {Selective retina therapy (SRT), Thermal stimulation of the retina (TSR),  Age- related macular  degeneration (AMD), Regeneration, Rejuvenation},
   type         = {Journal Article}
}

@article{Kleyman2021,
   author = {Kleyman, V;Schaller, M;Wilson, M;Mordmüller, M;Brinkmann, R;Worthmann, K and Müller, M.A.},
   title = {State and parameter estimation for model-based retinal laser treatment⁎⁎The collaborative project ”Temperature controlled retinal laser treatment” is funded by the German Research Foundation (DFG) under the project number 430154635 (MU 3929/3-1, WO 2056/7-1, BR 1349/6-1). MS was also funded by the DFG (grant WO 2056/2-1, project number 289034702). KW gratefully acknowledges funding by the German Research Foundation (DFG; grant WO 2056/6-1, project number 406141926)},
   journal = {IFAC-PapersOnLine},
   volume = {54(6)},
 
   pages = {244-250},
   ISSN = {2405-8963},
   DOI = {https://doi.org/10.1016/j.ifacol.2021.08.552},
   url = {https://www.sciencedirect.com/science/article/pii/S2405896321013276},
   year = {2021},
   type = {Journal Article}
}

@article{Mordmüller-2021,
   author = {Mordmüller, M;Kleyman, V;Schaller, M;Wilson, M;Theisen-Kunde, D;Worthmann, K;Müller, M.A and Brinkmann, R},
   title = {Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate},
   journal = {Advanced Optical Technologies},
Keywords = {extended Kalman filter; laser-coagulation; model predictive control; ophthalmology; photo-acoustics},
  
   url = {https://doi.org/10.1515/aot-2021-0041},
   year = {2021},
   type = {Journal Article}
}

@inproceedings{Theisen-Kunde:21,
author = {D. Theisen-Kunde and W. Draxinger and M. M. Bonsanto and Paul Strenge and Nicolas Detrez and R. Huber and R. Brinkmann},
booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)},
journal = {European Conferences on Biomedical Optics 2021 (ECBO)},
keywords = {Clinical applications; Fourier domain mode locking; Optical coherence tomography; Optical fibers; Three dimensional reconstruction; White light},
pages = {ETu4A.2},
publisher = {Optica Publishing Group},
title = {1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery},
year = {2021},
url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETu4A.2},
doi = {10.1364/ECBO.2021.ETu4A.2},
abstract = {A 1.6 MHz Fourier-domain mode-locked (FDML) optical coherence tomography (OCT) was adapted to an OR-Microscope for clinical application in neurosurgery. 3D-volume scans at video rate are envisaged with approximately 50{\textmu}m lateral and 20{\textmu}m axial resolution.},
}

@inproceedings{Mordmüller2021,
   author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R},
   title = { Towards Model-based Control Techniques for Retinal Laser
Treatment Using Only One Laser},
   booktitle = {ECBO},
url = {https://doi.org/10.1117/12.2615851},
year = {2021},
   type = {Conference Proceedings}
}

@article{RN5351,
   author = {Richert, E;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Roider, J and Tode, J},
   title = {Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models},
   journal = {Cytokine: X},
   volume = {2},
   number = {3},
   pages = {100031},
   ISSN = {2590-1532},
   DOI = {https://doi.org/10.1016/j.cytox.2020.100031},
   url = {https://www.sciencedirect.com/science/article/pii/S2590153220300112},
   year = {2020},
   type = {Journal Article}
}

@inproceedings{Strenge2020,
author = {P. Strenge and B. Lange and C. Grill and W. Draxinger and M. M. Bonsanto and C. Hagel and R. Huber and R. Brinkmann},
title = {{Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis}},
volume = {11228},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {82 -- 89},
keywords = {AG-Huber_OCT, Optical coherence tomography, OCT, FDML Laser, MHz-OCT, brain tumor, brain imaging, neurosurgery},
year = {2020},

URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11228/112282O/Segmented-OCT-data-set-for-depth-resolved-brain-tumor-detection/10.1117/12.2545659.short}
}

@article{brinkmann2020-2,
   author = {Luecking, M;Brinkmann, R;Ramos, Sc;Stork, W and Heussner, N},
   title = {Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage},
   journal = {CompBioMed},
   volume = {122},
   pages = {103835},
   ISSN = {0010-4825},
   DOI = {https://doi.org/10.1016/j.compbiomed.2020.103835},
 
   year = {2020},
   type = {Journal Article}
}

@article{Brinkmann2020,
   author = {Richert, E;Bartsch, S;Hillenkamp, J;Treumer, F;Tode, J;von der Burchard, C;Brinkmann, R;Klettner, A K and Roider, J},
   title = {Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums},
   journal = {Klin Monatsbl Augenheilkd},
   volume = {237(02)},
   
   pages = {192-201},
   ISSN = {0023-2165},
   DOI = {10.1055/a-0838-5633},
   year = {2020},
   type = {Journal Article}
}

@article{Kleymann2020,
   author = {Kleymann, V;Gernandt, H;Worthmann, K;Hossam, S.A;Brinkmann, R and Müller, A.M},
   title = {Modeling parameter for temperature controlled retinal laser therapies },
   journal = {DeGruyter-at-Automatisierungstechnik},
   volume = {68(11)},
keywords = {retinal photocoagulation, parametric model order
reduction, identification},
   pages = {953-966},
  URL = {https://www.degruyter.com/view/journals/auto/68/11/article-p953.xml},
   year = {2020},
   type = {Journal Article}
}

@article{Miura2020-2,
   author = {Yamamoto, M;Miura, Y;Hirayama, K;;Kohno, T;Kabata, D;Theisen-Kunde, D;Brinkmann, R and Honda, S;},
   title = {Predictive factors of outcome of selective retina therapy for diabetic macular edema},
   journal = {International Ophthalmology},
   ISSN = {1573-2630},
   
   url = {https://doi.org/10.1007/s10792-020-01288-6},
   year = {2020},
   type = {Journal Article}
}

@article{Richert2020,
   author = {Richert, E;Papenkort, J;Klettner, A;Tode, J;Koinzer, S;Brinkmann, R;Fink, C;Roeder, T;Lucius, R. and Roider, J},
   title = {Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)},
   journal = {Lasers in Surgery and Medicine},
Keywords = {age‐related macular degeneration; thermal stimulation therapy of the retinal pigment epithelium;
matrix metalloproteases; pigment epithelium derived factor; retinal pigment epithelium; vascular endothelial
growth factor; transforming growth factor‐β},
   DOI = {DOI 10.1002/lsm.23288},
   year = {2020},
   type = {Journal Article}
}

@article{Hirayama2020,
   author = {Hirayama, K.;Yamamoto, M.;Kohno, T.;Kyo, A.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.},
   title = {Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome},
   journal = {Graefes Arch Clin Exp Ophthalmol},
   ISSN = {0721-832x},
 volume = {259},
   pages = {387-393},
   DOI = {10.1007/s00417-020-04931-1},
   year = {2020},
   type = {Journal Article}
}

@article{yamamoto2020,
   author = {Yamamoto, M;Miura, Y;Kyo, A;Hirayama, K;Kohno, T;Theisen-Kunde, D;Brinkmann, R and Honda, S},
   title = {Selective retina therapy for subretinal fluid associated with choroidal nevus},
   journal = {Amer J Ophthalm Case Rep},
   volume = {19},
   pages = {100794},
   ISSN = {2451-9936},
keywords = {Laser therapy, Choroidal tumor, Retinal pigment epithelium, Retinal disorder},
   DOI = {https://doi.org/10.1016/j.ajoc.2020.100794},
   
   year = {2020},
   type = {Journal Article}
}

@inproceedings{10.1117/12.2507866,
author = {Jan Philip Kolb and Daniel Weng and Hubertus Hakert and Matthias Eibl and Wolfgang Draxinger and Tobias Meyer and Thomas Gottschall and Ralf  Brinkmann and Reginald Birngruber and J{\"u}rgen Popp and Jens Limpert and Sebastian Nino Karpf and Robert Huber},
title = {{Virtual HE histology by fiber-based picosecond two-photon microscopy}},
volume = {10882},
booktitle = {Multiphoton Microscopy in the Biomedical Sciences XIX},
editor = {Ammasi Periasamy and Peter T. C. So and Karsten K{\"o}nig},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {108822F},
abstract = {Two-Photon Microscopy (TPM) can provide three-dimensional morphological and functional contrast in vivo. Through proper staining, TPM can be utilized to create virtual, HE equivalent images and thus can improve throughput in histology-based applications. We previously reported on a new light source for TPM that employs a compact and robust fiber-amplified, directly modulated laser. This laser is pulse-to-pulse wavelength switchable between 1064 nm, 1122 nm, and 1186 nm with an adjustable pulse duration from 50ps to 5ns and arbitrary repetition rates up to 1MHz at kW-peak powers. Despite the longer pulse duration, it can achieve similar average signal levels compared to fs-setups by lowering the repetition rate to achieve similar cw and peak power levels. The longer pulses lead to a larger number of photons per pulse, which yields single shot fluorescence lifetime measurements (FLIM) by applying a fast 4 GSamples/s digitizer. In the previous setup, the wavelengths were limited to 1064 nm and longer. Here, we use four wave mixing in a non-linear photonic crystal fiber to expand the wavelength range down to 940 nm. This wavelength is highly suitable for imaging green fluorescent proteins in neurosciences and stains such as acridine orange (AO), eosin yellow (EY) and sulforhodamine 101 (SR101) used for histology applications. In a more compact setup, we also show virtual HE histological imaging using a direct 1030 nm fiber MOPA.},
keywords = {Multiphoton Microscopy, Four Wave Mixing, FWM, Histology, Laser, Non Linear Microscopy, Two Photon Microscopy, JenLab Young Investigator Award},
year = {2019},
doi = {10.1117/12.2507866},
URL = {https://doi.org/10.1117/12.2507866}
}

@article{Miura2019/3,
   
   author = {Miura, Y;Lewke, B;Hutfilz, A and Brinkmann, R},
   title = {Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress},
   journal = {Nippon Ganka Gakkai Zasshi },
  
   pages = {105-114},
   url = {http://journal.nichigan.or.jp/Disp?style=abst&vol=123&year=2019&mag=0&number=2&start=105},
   year = {2019},
   type = {Journal Article}
}

@article{Miura2019,
   author = {Hirayama, K;Manabu Yamamoto, M; Takeya Kohno, T; Miura, Y; Brinkmann, R;  Shiraki,K;Theisen-Kunde, D; and Honda, S;},
   title = {Change in the Thickness of Retinal Layers after Selective Retina
Therapy (SRT) in Patients with Central Serous Chorioretinopathy},
   journal = {Osaka City Med.},
   volume = {65},
   pages = {55-63},
   url = {http://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-65-1-55},
   year = {2019},
   type = {Journal Article}
}

@article{Hutfilz2019,
   author = {Hutfilz, A;Sonntag, S;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y},
   title = {Fluorescence Lifetime Imaging Ophthalmoscopy of the Retinal Pigment Epithelium During Wound Healing After Laser Irradiation},
   journal = {Translational Vision Science & Technology},
   volume = {8(5)},
 
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.8.5.12},
   year = {2019},
   type = {Journal Article}
}

@article{Brinkmann2020,
   author = {Strittmatter, F;Eisel, M; Brinkmann, R; Cordes, J;Lange, B and Sroka, R},
   title = {Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned},
   journal = {Translational Biophotonics},
   volume = {n/a},
   number = {n/a},
   pages = {e201900029},
   ISSN = {2627-1850},
   DOI = {10.1002/tbio.201900029},
   url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/tbio.201900029},
   year = {2019},
   type = {Journal Article}
}

@article{Miura2019/4,
   author = {Miura, Y;Seifert, E;Rehra, J;Kern, K;Theisen-Kunde, D;Denton, M and Brinkmann, R},
   title = {Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study},
   journal = {Int J Hyperth},
   pages = {1-7},
   ISSN = {0265-6736},
  
   url = {https://doi.org/10.1080/02656736.2019.1590653},
   year = {2019},
   type = {Journal Article}
}

@inbook{Brinkmann2019,
   author = {Považay, Boris;Brinkmann, Ralf;Stoller, Markus and Kessler, Ralf},
   title = {Selective Retina Therapy},
   booktitle = {High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics},
   editor = {Bille, Josef F.},
   publisher = {Springer International Publishing},
   address = {Cham},
   pages = {237-259},
   ISBN = {978-3-030-16638-0},
  
   url = {https://doi.org/10.1007/978-3-030-16638-0_11},
   year = {2019},
   type = {Book Section}
}

@inproceedings{Detrez2019,
   author = {Detrez, N;Miura, Y;Seifert, E;Theisen-Kunde, D and Brinkmann, R},
   title = {Heating and optoacoustic temperature determination of cell cultures},
   publisher = {SPIE},
   volume = {11079},
   series = {European Conferences on Biomedical Optics},
booktitle =    {Proc. SPIE 11079, Medical Laser Applications
and Laser-Tissue Interactions IX},
   url = {https://doi.org/10.1117/12.2527024},
keywords = {Laser, Noninvasive thermometry, hyperthermia, temperature measurement, photoacoustics}, optoacoustics,
   year = {2019},
   type = {Conference Proceeding}
}

@article{seifert2018,
   author = {Seifert, E; Tode, J; Pielen, A; Theisen-Kunde, D; Framme, C; Roider, J; Miura, Y; Birngruber, R and Brinkmann, R},
   title = {Selective retina therapy: toward an optically controlled automatic dosing},
   journal = {J Biomed Opt},
   
   pages = {1-12},
   ISSN = {1560-2281 (Electronic)
1083-3668 (Linking)},
   DOI = {10.1117/1.JBO.23.11.115002},   
keywords = {algorithm, lasers in medicine, ophthalmology, retinal pigment epithelium, selective retina therapy, selectivity},
   year = {2018},
   type = {Journal Article}
}