@inproceedings{Xie,
   author = {Xie, Y. and Bonin, T. and Loeffler, S. and Huettmann, G. and Tronnier, V. and Hofmann, U. G.},
   title = {Fiber spectral domain optical coherence tomography for in vivo rat brain imaging},
   editor = {Jurgen, Popp and Wolfgang, Drexler and Valery, V. Tuchin and Dennis, L. Matthews},
   publisher = {SPIE},
   volume = {7715},
   pages = {77152F},
year = { 2010},
URL = { https://doi.org/10.1117/12.854798}

}

@inproceedings{Rahmanzadeh,
   author = {Rahmanzadeh, Ramtin and Rai, Prakash and Gerdes, Johannes and Hasan, Tayyaba},
   title = {Targeted light-inactivation of the Ki-67 protein using theranostic liposomes leads to death of proliferating cells},
   editor = {Samuel, Achilefu and Ramesh, Raghavachari},
   publisher = {SPIE},
   volume = {7576},
   pages = {757602},
year = {2010},
doi ={10.1117/12.843850},
keywords = {Nanotechnology, Ovarian Cancer, Proliferative Index, Photodynamic Therapy,Antibody}

}

@INPROCEEDINGS{5343314,
  author={Huber, Robert},
  booktitle={2009 IEEE LEOS Annual Meeting Conference Proceedings}, 
  title={Advances in Fourier domain OCT}, 
  year={2009},
  volume={},
  number={},
  pages={201-202},
  abstract={In optical coherence tomography, the introduction of so called ldquoFrequency Domainrdquo techniques, i.e. spectrally resolved detection, had a dramatic impact on these biomedical imaging systems. The current status and future developments will be discussed.},
  keywords={},
  doi={10.1109/LEOS.2009.5343314},
  ISSN={1092-8081},
  month={Oct},}

@inproceedings{10.1117/12.831831,
author = {Christoph M. Eigenwillig and Benjamin R. Biedermann and Wolfgang Wieser and Robert Huber},
title = {{Wavelength swept ASE source}},
volume = {7372},
booktitle = {Optical Coherence Tomography and Coherence Techniques IV},
editor = {Peter E. Andersen and Brett E. Bouma},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {73720O},
abstract = {We present a novel wavelength swept light source for Optical Coherence Tomography (OCT). Arbitrary sweep rates up
to 2x170kHz are achieved by phase-shifted control of two optical bandpass-filters to compensate light propagation
effects.},
keywords = {amplified spontaneous emission, tunable lasers, lasers, optical coherence tomography, optical frequency domain imaging},
year = {2009},
doi = {10.1117/12.831831},
URL = {https://doi.org/10.1117/12.831831}
}

@inproceedings{10.1117/12.831835,
author = {Gesa Palte and Wolfgang Wieser and Benjamin R. Biedermann and Christoph M. Eigenwillig and Robert Huber},
title = {{Fourier domain mode locked (FDML) lasers for polarization sensitive OCT}},
volume = {7372},
booktitle = {Optical Coherence Tomography and Coherence Techniques IV},
editor = {Peter E. Andersen and Brett E. Bouma},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {73720M},
abstract = {A Fourier Domain mode-locked (FDML) laser for polarization sensitive optical coherence tomography (OCT) is
presented. The laser generates an alternating sequence of wavelength sweeps with their polarization states 90° separated
on the Poincare sphere.},
keywords = {Lasers, tunable, optical coherence tomography, lasers, imaging systems, polarization, fiber},
year = {2009},
doi = {10.1117/12.831835},
URL = {https://doi.org/10.1117/12.831835}
}

@INPROCEEDINGS{5191695,
  author={Huber, Robert},
  booktitle={CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference}, 
  title={State-of-the-art and future of ultrahigh speed OCT}, 
  year={2009},
  volume={},
  number={},
  pages={1-1},
  abstract={This paper reviews the current status of high speed OCT systems on the different levels of development: commercial, laboratory prototype style and proof of concept type systems. The pro and contra of SD-OCT and SS-OCT are discussed and an analysis of the desired optimum imaging speeds for various applications. SS-OCT systems are used for imaging in highly scattering tissue ~1300 nm, a line rate of 60 MHz was achieved by with SD-OCT.},
  keywords={},
  doi={10.1109/CLEOE-EQEC.2009.5191695},
  ISSN={},
  month={June},}

@INPROCEEDINGS{5192900,
  author={Biedermann, Benjamin R. and Wieser, Wolfgang and Eigenwillig, Christoph M. and Klein, Thomas and Huber, Robert},
  booktitle={CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference}, 
  title={Dispersion, coherence and noise of Fourier Domain Mode Locked (FDML) lasers}, 
  year={2009},
  volume={},
  number={},
  pages={1-1},
  abstract={We present a detailed analysis of coherence and noise of the FDML laser, depending on filter drive frequency, detuning and amount of cavity dispersion. The results provide insight into phase and amplitude noise of the laser light itself. We address the following two questions: (1) How much dispersion compensation is necessary for optimum laser performance in FDML for a certain width of the optical band pass filter? (2) How are timing mismatch effects, caused by either detuning of the drive frequency or chromatic dispersion in the cavity of the filter, related to coherence length and noise?},
  keywords={},
  doi={10.1109/CLEOE-EQEC.2009.5192900},
  ISSN={},
  month={June},}

@INPROCEEDINGS{5194704,
  author={Klein, Thomas and Wieser, Wolfgang and Biedermann, Benjamin R. and Eigenwillig, Christoph M. and Palte, Gesa and Huber, Robert},
  booktitle={CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference}, 
  title={Raman pumped Fourier Domain Mode Locked (FDML) laser: Analysis of operation and application for optical coherence tomography (OCT)}, 
  year={2009},
  volume={},
  number={},
  pages={1-1},
  abstract={limitations of the sweep repetition rate of rapidly wavelength swept laser sources. Such sources can be applied for optical coherence tomography (OCT) using frequency domain detection. This technique is called swept source OCT (ss-OCT) or optical frequency domain imaging (OFDI). FDML lasers usually consist of a semiconductor optical amplifier (SOA) as laser gain medium, an output coupler, a periodically driven optical band-pass filter (FFP-TF) and an optical delay line, so that their total length is typically several kilometres.},
  keywords={},
  doi={10.1109/CLEOE-EQEC.2009.5194704},
  ISSN={},
  month={June},}

@inproceedings{10.1117/12.808555,
author = {Karol Karnowski and Michalina Gora and Bartlomiej Kaluzny and Robert Huber and Maciej Szkulmowski and Andrzej Kowalczyk and Maciej Wojtkowski},
title = {{Swept source OCT imaging of human anterior segment at 200 kHz}},
volume = {7163},
booktitle = {Ophthalmic Technologies XIX},
editor = {Fabrice Manns and Per G. S{\"o}derberg and Arthur Ho},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {716308},
abstract = {We present applicability of the high speed swept-source optical coherence tomography for in vivo imaging of the anterior segment of the human eye. Three dimensional imaging of the cornea with reduced motion artifacts is possible by using swept source with Fourier domain mode locking operating at 200kHz with 1300nm central wavelength. High imaging speeds allow for assessment of anterior and posterior corneal topography and generation of thickness and elevation maps.},
keywords = {Optical Coherence Tomography, Fourier domain detection methods, swept source OCT, anterior segment of the eye},
year = {2009},
doi = {10.1117/12.808555},
URL = {https://doi.org/10.1117/12.808555}
}

@inproceedings{Hillmann,
   author = {Hillmann, Dierck and Huttmann, Gereon and Koch, Peter},
   title = {Using nonequispaced fast Fourier transformation to process optical coherence tomography signals},
   editor = {Peter, E. Andersen and Brett, E. Bouma},
   publisher = {SPIE},
   volume = {7372},
   pages = {73720R},
url = { https://doi.org/10.1364/ECBO.2009.7372_0R},
year = { 2009}

}

@inproceedings{Langejürgen2009,
   author = {Langejürgen, J and Schlott, K and Bever, M and Hausmann, K and Koinzer, S and Ptaszynski, L and Roider, J and Birngruber, R and Brinkmann, R},
   title = {Dependence of optoacoustic transients on exciting laser parameters for real-time monitoring of retinal photocoagulation},
   pages = {73730K-73730K},
   note = {10.1117/12.831913},
   abstract = {The extent of retinal laser coagulations depends on the temperature increase at the fundus and the time of irradiation. Due to light scattering within the eye and variable fundus pigmentation the induced temperature increase and therefore the extent of the coagulations cannot be predicted solely from the laser parameters. We use optoacoustics to monitor the temperature rise in real-time in vivo (rabbit) and ex vivo (porcine eye) and to automatically control the coagulation strength. Continuous wave treatment laser radiation and pulsed probe laser light (1-1100 ns) are coupled into the same fibre and are imaged onto the retina by a laser slit lamp. The temperature dependent pressure waves are detected by an ultrasonic transducer embedded in a customary contact lens. Below the coagulation threshold the increase in acoustic amplitude due to thermal tissue expansion is up to 40 %. Best signal to noise ratios > 10 are achieved with probe pulse durations of 1 to 75 ns. Further a time critical algorithm is developed which automatically ceases laser treatment when a certain preset coagulation strength is achieved. Coagulations with similar extent are obtained with this method in vitro and in vivo even when varying the power of the treatment laser by 50 %. These preliminary results are very promising, thus this method might be suitable for an automatic feedback controlled photocoagulation with adjustable coagulation strength.},
url = {http://dx.doi.org/10.1117/12.831913},
   type = {Conference Proceedings},
Year = { 2009}
}

@inproceedings{Fritz2009,
   author = {Fritz, A and Ptaszynski, L and Stoehr, H and Brinkmann, R},
   title = {Dynamic of laser induced transient microbubble clusters},
   editor = {(BiOS), Conference on Biomedical Optics},
   publisher = {Proc SPIE},
   type = {Conference Proceedings},
year = { 2009},
URL = { https://www.osapublishing.org/abstract.cfm?uri=ECBO-2009-7373_0D}
}

@inproceedings{Schlott2009,
   author = {Schlott, Kerstin and Langejürgen, Jens and Bever, Marco and Koinzer, Stefan and Birngruber, Reginald and Brinkmann, Ralf},
   title = {Time resolved detection of tissue denaturation during retinal photocoagulation},
   editor = {7373, Proc. SPIE},
   pages = {73730E-73730E},
   note = {10.1117/12.831877},
   abstract = {The retinal photocoagulation is an established treatment method for different retinal diseases. The extent of the thermal coagulations depends strongly on the generated temperature increase. Until now the dosage is based on a pool of experience of the treating physicians as well as the appearance of the whitish lesions on the retina. The temperature course during photocoagulation can be measured in real-time by optoacoustics. A frequency-doubled Q-switched Nd:YLF laser (523nm, 75 ns) is used for optoacoustic excitation and a continuous-wave Nd:YAG laser (532nm) with adjustable irradiation time and power for heating of the fundus tissue. The onset of coagulation is determined by a photodiode that is placed directly behind enucleated porcine eyes, which served as a model. The onset of coagulation is observed clearly when scattering sets in. The required power for coagulation increases exponentially with decreasing irradiation time. The first results on rabbit eyes in vivo indicate that the onset of coagulation defined by just barely visibile lesions at a slit lamp sets in at an ED50 threshold temperature of 63°C for an irradiation time of 400 ms. In conclusion, optoacoustics can be used to determine temperatures during retinal laser treatments in real-time. This allows evaluating the time-temperature-dependence of retinal coagulation in vivo.},
   keywords = {AutoPhoN},
   url = {http://dx.doi.org/10.1117/12.831877},
   type = {Conference Proceedings},
year = { 2009},
url = { https://doi.org/10.1117/12.168030}
}

@INPROCEEDINGS{4571261,
  author={Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert},
  booktitle={2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science}, 
  title={Optical coherence tomography imaging with k-space linear fourier domain mode locked lasers}, 
  year={2008},
  volume={},
  number={},
  pages={1-2},
  abstract={We report on a Fourier Domain Mode Locked wavelength swept laser source with a highly linear time-frequency sweep characteristic and demonstrate OCT imaging without k-space resampling prior to Fourier transformation with this source.},
  keywords={},
  doi={10.1109/CLEO.2008.4551011},
  ISSN={},
  month={May},}

@INPROCEEDINGS{4571888,
  author={Jirauschek, Christian and Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert},
  booktitle={2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science}, 
  title={Fourier domain mode locking theory}, 
  year={2008},
  volume={},
  number={},
  pages={1-2},
  abstract={We present a theoretical model for the recently developed Fourier domain mode locked (FDML) lasers. The good agreement with experiment provides valuable insights into the mechanism of FDML operation.},
  keywords={},
  doi={10.1109/CLEO.2008.4551638},
  ISSN={},
  month={May},}

@inproceedings{10.1117/12.761850,
author = {Desmond C. Adler and Yu Chen and Robert Huber and Joseph Schmitt and James Connolly and James G. Fujimoto},
title = {{In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers}},
volume = {6847},
booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII},
editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {684708},
abstract = {We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked
(FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning
fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial
lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of
the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable
feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is
demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With
further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of
axial lines/s supported by FDML lasers.},
keywords = {Optical coherence tomography, Endoscopic microscopy, Fourier Domain Mode Locked lasers, FDML, Three dimensional microscopy, In vivo microscopy, Biomedical optics, Swept source optical coherence tomography},
year = {2008},
doi = {10.1117/12.761850},
URL = {https://doi.org/10.1117/12.761850}
}

@inproceedings{Just-2008,
   author = {Just, T. and Lankenau, E. and Huettmann, G. and Pau, H.W.},
   title = {Optical coherence tomography as a guide for cochlear implant surgery},
   booktitle = {Progress in Biomedical Optics and Imaging},
   editor = {Nikiforos, K. and Bernard, C. and Haishan, Z.},
   publisher = {SPIE 6842},
   pages = {F1-F6},
url = { https://doi.org/10.1117/12.771446},
year = { 2008}

}

@inproceedings{Steven-2008,
   author = {Steven, Philip and Koop, Norbert and Huttmann, Gereon},
   title = {Confocal microscopy versus two-photon microscopy: imaging of ocular surface pathologies},
   editor = {Ammasi, Periasamy and Peter, T. C. So},
   publisher = {SPIE},
   volume = {6860},
   pages = {686023},
year = { 2008}
}

@InProceedings{HU_2008_Adlera,
  Title                    = {{In vivo endomicroscopy using three-dimensional optical coherence tomography and {Fourier} domain mode locked lasers}},
  Author                   = {Adler, Desmond C. and Chen, Yu and Huber, Robert and Schmitt, Joseph and Connolly, James and Fujimoto, James G.},
  Booktitle                = {Biomedical Optics (BiOS) 2008},
  Year                     = {2008},
  Editor                   = {Izatt, Joseph A. and Fujimoto, James G. and Tuchin, Valery V.},
  Month                    = feb,
  Pages                    = {684708--684708--7},
  Publisher                = {International Society for Optics and Photonics},

  Doi                      = {10.1117/12.761850},
  Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1326810\&resultClick=1}
}

@inproceedings{Huber:07,
author = {Robert Huber and Vivek J. Srinivasan and Desmond C. Adler and I. Gorczynska and James G. Fujimoto},
booktitle = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies},
journal = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies},
keywords = {General physics; General science; Fourier domain mode locking; Image quality; In vivo imaging; Laser sources; Ophthalmic imaging; Optical coherence tomography},
pages = {CThAA5},
publisher = {Optica Publishing Group},
title = {Fourier Domain Mode Locking (FDML) in the non-zero dispersion regime: A laser for ultrahigh-speed retinal OCT imaging at 236kHz line rate},
year = {2007},
url = {https://opg.optica.org/abstract.cfm?URI=CLEO-2007-CThAA5},
abstract = {Fourier Domain Mode Locking (FDML) in the 1070nm wavelength range is investigated. Problems, design rules and the performance of an FDML laser with a dispersive cavity are discussed. Retinal OCT imaging at 236kHz is demonstrated.},
}

@INPROCEEDINGS{4452406,
  author={Adler, Desmond C. and Huber, Robert and Fujimoto, James G.},
  booktitle={2007 Conference on Lasers and Electro-Optics (CLEO)}, 
  title={Optical Coherence Tomography Phase Microscopy Using Buffered Fourier Domain Mode Locked (FDML) Lasers at up to 370,000 Lines per Second}, 
  year={2007},
  volume={},
  number={},
  pages={1-2},
  abstract={Buffered FDML lasers are applied for phase-sensitive sub-nanometer OCT phase microscopy and dynamic surface displacement measurements at speeds up to 370,000 axial lines per second. Excellent phase stability is demonstrated at high speeds.},
  keywords={},
  doi={10.1109/CLEO.2007.4452406},
  ISSN={2160-9004},
  month={May},}

@inproceedings{10.1117/12.704084,
author = {Robert A. Huber and Desmond C. Adler and Vivek J. Srinivasan and Iwona M Gorczynska and James G. Fujimoto},
title = {{Fourier domain mode-locked (FDML) lasers at 1050 nm and 202,000 sweeps per second for OCT retinal imaging}},
volume = {6429},
booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI},
editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {642907},
abstract = {Retinal imaging ranks amongst the most important clinical applications for optical coherence
tomography (OCT) [1, 2]. The recent demonstration of increased sensitivity [3-6] in Fourier
Domain detection [7, 8] has opened the way for dramatically higher imaging speeds, up to axial
scan rates of several tens of kilohertz. However, these imaging speeds are still not sufficient for
high density 3D datasets and a further increase to several hundreds of kilohertz is necessary. In
this paper we demonstrate a swept laser source at 1050 nm with a sweep rate of 202 kHz. The
laser source provides ~10 mW average output power, up to 60 nm total sweep range and a
sensitivity roll off of less than 10 dB over 4 mm. In vivo 2D and 3D imaging of the human retina
at a record axial scan rate of 101 kHz is demonstrated. These results suggest that swept source
OCT has the potential to significantly outperform spectral/Fourier domain OCT for ophthalmic
imaging applications in the future.},
keywords = {tunable laser, optical coherence tomography, Fourier domain mode locking, swept source, OCT, FDML, retinal imaging, ophthalmic imaging},
year = {2007},
doi = {10.1117/12.704084},
URL = {https://doi.org/10.1117/12.704084}
}

@inproceedings{10.1117/12.704128,
author = {Desmond C. Adler and Robert Huber and James G. Fujimoto},
title = {{Phase-sensitive optical coherence tomography using buffered Fourier domain mode-locked lasers at up to 370,000 scans per second}},
volume = {6429},
booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI},
editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {64291L},
abstract = {Phase sensitive optical coherence tomography (OCT) can be used to obtain sub-nanometer
displacement measurements of biological and non-biological samples. This technique has many
applications, including detection of small amplitude surface motion, and high axial resolution OCT
phase microscopy. Doppler OCT is another type of phase sensitive imaging, where differential
phase measurements are used to detect fluid flow in biological specimens. For all types of phase
sensitive OCT, a light source with low phase noise is required in order to provide good
displacement sensitivity. High speed imaging is also necessary in order to minimize motion artifacts
and enable the detection of fast transient events. In this manuscript, buffered Fourier Domain Mode
Locked (FDML) lasers are demonstrated for ultrahigh-speed phase sensitive OCT detection. The
lasers are operated at sweep speeds of 42, 117, and 370 kHz, and displacement sensitivities of 39,
52, and 102 pm are achieved, respectively. These displacement sensitivities are comparable to
spectrometer-based phase sensitive OCT systems, but acquisition speeds 1.4 - 13x faster are
possible using buffered FDML lasers. An additional factor of √2 improvement in noise performance
is observed for differential phase measurements, which has important implications for Doppler
OCT. Dynamic measurements of rapid, small-amplitude piezoelectric transducer motion are
demonstrated. In general, buffered FDML lasers provide excellent displacement sensitivities at
extremely high sweep speeds for phase sensitive OCT measurements.},
keywords = {optical coherence tomography, OCT, optical coherence phase microscopy, swept source phase microscopy, doppler optical coherence tomography, frequency swept lasers, Fourier Domain Mode Locked lasers, FDML},
year = {2007},
doi = {10.1117/12.704128},
URL = {https://doi.org/10.1117/12.704128}
}

@inproceedings{Fritz2007,
   author = {Fritz, Andreas and Ptaszynski, Lars and Stoehr, Hardo and Brinkmann, Ralf},
   title = {Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE)},
   volume = {6632},
   pages = {66321C-66321C-11},
   note = {10.1117/12.728344},
   abstract = {Selective Retina Treatment (SRT) is a new method to treat eye diseases associated with disorders of the RPE. Selective RPE cell damage is achieved by applying a train of 1.7 μs laser pulses at 527 nm. The treatment of retinal diseases as e.g. diabetic maculopathy (DMP), is currently investigated within clinical studies, however 200 ns pulse durations are under investigation. Transient micro bubbles in the retinal pigment epithelium (RPE) are expected to be the origin of cell damage due to irradiation with laser pulses shorter than 50 μs. The bubbles emerge at the strongly absorbing RPE melanosomes. Cell membrane disruption caused by the transient associated volume increase is expected to be the origin of the angiographically observed RPE leakage. We investigate micro bubble formation and dynamics in porcine RPE using pulse durations of 150 ns. A laser interferometry system at 830 nm with the aim of an online dosimetry control for SRT was developed. Bubble formation was detected interferometrically and by fast flash photography. A correlation to cell damage observed with a vitality stain is found. A bubble detection algorithm is presented.},
   url = {http://dx.doi.org/10.1117/12.728344},
   type = {Conference Proceedings}
}

@inproceedings{Herrmann2007,
   author = {Herrmann, Katharina and Flöhr, Christian and Stalljohann, Jens and Apiou-Sbirlea, Gabriela and Kandulla, Jochen and Birngruber, Reginald and Brinkmann, Ralf},
   title = {Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments},
   volume = {6632},
   pages = {66321D-66321D-7},
   note = {10.1117/12.728222},
   abstract = {In most retinal laser treatments the therapeutic effect is initiated by a transient temperature increase at and around the retinal pigment epithelium (RPE). Especially in long exposure time treatments like Transpupillary Thermotherapy (TTT) choroidal perfusion has a strong influence on the realized temperature at the fundus. The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here. In order to reduce the choroidal perfusion, the IOP is increased by injection of physiological saline solution into the eye of anaesthetized rabbits. The fundus is irradiated with 3.64 W/cm2 by means of a TTT-laser (λ = 810 nm) for t = 20 s causing a retinal temperature increase. Realtime temperature determination at the irradiated spot is achieved by a non invasive optoacoustic technique. Perfusion can be reduced by increasing IOP, which leads to different temperature increases when irradiating the retina. This should be considered for long time laser treatments.},
   url = {http://dx.doi.org/10.1117/12.728222},
   type = {Conference Proceedings},
year = { 2007}
}