@inproceedings{10.1117/12.2286035,
author = {Matthias Eibl and Sebastian Karpf and Hubertus Hakert and Daniel Weng and Tom Pfeiffer and Jan Philip Kolb and Robert Huber},
title = {{Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup }},
volume = {10414},
booktitle = {Advances in Microscopic Imaging},
editor = {Emmanuel Beaurepaire and Francesco Saverio Pavone and Peter T. C. So},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1041403},
abstract = {Newly developed microscopy methods have the goal to give researches in bio-molecular science a better understanding of processes ongoing on a cellular level. Especially two-photon excited fluorescence (TPEF) microscopy is a readily applied and widespread modality. Compared to one photon fluorescence imaging, it is possible to image not only the surface but also deeper lying structures. Together with fluorescence lifetime imaging (FLIM), which provides information on the chemical composition of a specimen, deeper insights on a molecular level can be gained. However, the need for elaborate light sources for TPEF and speed limitations for FLIM hinder an even wider application. In this contribution, we present a way to overcome this limitations by combining a robust and inexpensive fiber laser for nonlinear excitation with a fast analog digitization method for rapid FLIM imaging. The applied sub nanosecond pulsed laser source is perfectly suited for fiber delivery as typically limiting non-linear effects like self-phase or cross-phase modulation (SPM, XPM) are negligible. Furthermore, compared to the typically applied femtosecond pulses, our longer pulses produce much more fluorescence photons per single shot. In this paper, we show that this higher number of fluorescence photons per pulse combined with a high analog bandwidth detection makes it possible to not only use a single pulse per pixel for TPEF imaging but also to resolve the exponential time decay for FLIM. To evaluate our system, we acquired FLIM images of a dye solution with single exponential behavior to assess the accuracy of our lifetime determination and also FLIM images of a plant stem at a pixel rate of 1 MHz to show the speed performance of our single pulse two-photon FLIM (SP-FLIM) system.},
keywords = {Nonlinear microscopy, Fluorescence microscopy, Fiber optics imaging, Lifetime-based sensing, Lasers, fiber, Nonlinear optics, fibers},
year = {2017},
doi = {10.1117/12.2286035},
URL = {https://doi.org/10.1117/12.2286035}
}

@inproceedings{10.1117/12.2217572,
author = {Sijia Wang and Gereon H{\"u}ttmann and Tayyaba Hasan and Ramtin Rahmanzadeh},
title = {{Molecular targeted PDT with selective delivery of ICG Photo-Immunoconjugates
(Conference Presentation)}},
volume = {9694},
booktitle = {Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXV},
editor = {David H. Kessel and Tayyaba Hasan},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {96940O},
keywords = {photodynamic therapy, liposome, endosomal entrapment, nanotechnology, cell proliferation, photochemical internalization},
year = {2016},
doi = {10.1117/12.2217572},
URL = {https://doi.org/10.1117/12.2217572}
}

@inproceedings{10.1117/12.2214758,
author = {Jan Philip Kolb and Thomas Klein and Matthias Eibl and Tom Pfeiffer and Wolfgang Wieser and Robert Huber},
title = {{Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm}},
volume = {9697},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX},
editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {969703},
abstract = {We present a new design of a Fourier Domain Mode Locked laser (FDML laser), which provides a new record in sweep
range at ~1μm center wavelength: At the fundamental sweep rate of 2x417 kHz we reach 143nm bandwidth and 120nm
with 4x buffering at 1.67MHz sweep rate. The latter configuration of our system is characterized: The FWHM of the
point spread function (PSF) of a mirror is 5.6μm (in tissue). Human in vivo retinal imaging is performed with the MHz
laser showing more details in vascular structures. Here we could measure an axial resolution of 6.0μm by determining
the FWHM of specular reflex in the image. Additionally, challenges related to such a high sweep bandwidth such as
water absorption are investigated.},
keywords = {Optical coherence tomography, OCT, tunable laser, Fourier domain mode locking, FDML, MHz OCT},
year = {2016},
doi = {10.1117/12.2214758},
URL = {https://doi.org/10.1117/12.2214758}
}

@inproceedings{Spahr2016,
   author = {Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon},
   title = {Imaging vascular dynamics in human retina using full-field swept-source optical coherence tomography (Conference Presentation)},
   volume = {9697},
   pages = {96970E-96970E-1},
   note = {10.1117/12.2214303},
   abstract = {We demonstrate a new non-invasive method to assess the functional condition of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. Motion of retinal tissue, that is induced by expansion of the vessels therein, is measured with an accuracy of about 10 nm. The pulse shape of arterial and venous pulsation, their temporal delay as well as the frequency dependent pulse propagation through the capillary bed are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.},
   url = {http://dx.doi.org/10.1117/12.2214303},
   type = {Conference Proceedings},
year = { 2016}
}

@inproceedings{Pieper2016,
   author = {Pieper, Mario and Schulz-Hildebrandt, Hinnerk and Hüttmann, Gereon and König, Peter},
   title = {Imaging of mucus clearance in the airways of living spontaneously breathing mice by optical coherence microscopy (Conference Presentation)},
   volume = {9691},
   pages = {969116-969116-1},
year = { 2016},
   note = {10.1117/12.2209054},
   abstract = {Mucus transport is essential to remove inhaled particles and pathogens from the lung. Impaired removal of mucus often results in worsening of lung diseases. To understand the mechanisms of mucus transport and to monitor the impact of therapeutic strategies, it is essential to visualize airways and mucus in living animals without disturbing transport processes by intubation or surgically opening the airways. We developed a custom-built optical coherence microscope (OCM) providing a lateral and axial resolution of approximately 1.5 µm with a field of view of 2 mm at up to 150 images/s. Images of the intact trachea and its mucus transport were recorded in anesthetized spontaneously breathing mice. NaCl solution (0.9% and 7%) or Lipopolysaccharide were applied intranasally. OCM resolved detailed structure of the trachea and enabled measuring the airway surface liquid (ASL) thickness through the tracheal wall. Without stimulation, the amount of ASL was only a few µm above the epithelium and remained constant. After intranasal application of 30 µl saline at different concentrations, an early fast cough-like fluid removal with velocities higher than 1 mm/s was observed that removed a high amount of liquid. The ASL thickness increased transiently and quickly returned to levels before stimulation. In contrast to saline, application of Lipopolysaccharide induced substantial mucus release and an additional slow mucus transport by ciliary beating (around 100 µm/s) towards the larynx was observed. In conclusion, OCM is appropriate unique tool to study mechanisms of mucus transport in the airways and effects of therapeutic interventions in living animals.},
   url = {http://dx.doi.org/10.1117/12.2209054},
   type = {Conference Proceedings}
}

@INPROCEEDINGS{Strauch2017,
author={Strauch, M and Urbach, H P},
booktitle={2016 IEEE Photonics Conference (IPC)},
title={Surface harmonics on liquid lenses},
year={2016},

pages={248-249},
keywords={lenses;optical harmonic generation;optical tuning;oscillations;surface harmonics;liquid lenses;tunability;nonspherical surfaces;surface oscillations;Lenses;Liquids;Surface waves;Optical surface waves;Harmonic analysis;Shape;Optical switches},
doi={10.1109/IPCon.2016.7831063},
ISSN={},
month={Oct},}

@inproceedings{10.1117/12.2077659,
author = {Jan Philip Kolb and Philipp Schwarz and Thomas Klein and Wolfgang Wieser and Robert Huber},
title = {{Dual parametric compounding approach for speckle reduction in OCT}},
volume = {9312},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX},
editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {93123G},
abstract = {OCT as a coherent imaging technique inherently suffers from speckle. We present a new dual parametric compounding approach to reduce speckle. The approach is to acquire several OCT volumes with different numerical apertures (NAs). Then in post processing, a first spatial compounding step is performed by averaging of adjacent B-frames. In a second step data from the different volume is averaged. Retinal imaging data comparing this idea with standard spatial compounding is presented and analyzed and necessary parameters such as the required variation of the NA and number of different NAs are discussed},
keywords = {Optical coherence tomography, OCT, tunable laser, Fourier domain mode lockng, FDML, MHz OCT},
year = {2015},
doi = {10.1117/12.2077659},
URL = {https://doi.org/10.1117/12.2077659}
}

@inproceedings{10.1117/12.2183822,
author = {Matthias Eibl and Sebastian Karpf and Wolfgang Wieser and Thomas Klein and Robert Huber},
title = {{Hyperspectral stimulated Raman microscopy with two fiber laser sources}},
volume = {9536},
booktitle = {Advanced Microscopy Techniques IV; and Neurophotonics II},
editor = {Emmanuel Beaurepaire and Peter T. C. So and Francesco Pavone and Elizabeth M. Hillman},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {953604},
abstract = {A fast all fiber based setup for stimulated Raman microscopy based on a rapidly wavelength swept cw-laser is presented. The applied Fourier domain mode locked (FDML) laser is a fiber ring laser, providing a continuously changing wavelength output over time. This fast swept source allows us to rapidly change the wavelength and, thereby the energy difference with respect to a single color pump laser. The pump laser is a master oscillator power amplifier based on a fiber amplified laser diode and a Raman shifter. By controlled variation of the relative timing between probe and pump laser with an arbitrary waveform generator, the Raman signals are encoded in time and they are directly acquired with a synchronized, fast analog-to-digital converter. This setup is capable of acquiring rapidly high resolution spectra (up to 0.5 cm<sup>-1</sup>) with shot noise limited sensitivity over a broadband (750 cm<sup>-1</sup> to 3150 cm<sup>-1</sup>) spectral region. Here, we show the performance of this system for imaging in the CH-stretch region around 3000 cm<sup>-1</sup> and in the fingerprint region around 1600 cm<sup>-1</sup>. We present hyperspectral images of a plant stem slice with molecular contrast of lignin and a lipid representative as well as images of PS (polystyrene) and PMMA (poly(methyl methacrylate) beads with an acquisition speed of 18 &mu;s per spectral point.},
keywords = {stimulated Raman, multiphoton, microscopy, coherent Raman, fiber laser, FDML, TICO, hyperspectral},
year = {2015},
doi = {10.1117/12.2183822},
URL = {https://doi.org/10.1117/12.2183822}
}

@inproceedings{10.1117/12.2183768,
author = {Jan Philip Kolb and Thomas Klein and Wolfgang Wieser and Wolfgang Draxinger and Robert Huber},
title = {{High definition in vivo retinal volumetric video rate OCT at 0.6 Giga-voxels per second}},
volume = {9541},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media},
editor = {Brett E. Bouma and Maciej Wojtkowski},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {95410Z},
abstract = {We present full volumetric high speed OCT imaging of the retina with multiple settings varying in volume size and volume rate. The volume size ranges from 255x255 A-scans to 160x40 A-scans with 450 samples per depth scan with volume rates varying between 20.8 V/s for the largest volumes to 195.2 V/s for the smallest. The system is based on a 1060nm Fourier domain mode locked (FDML) laser with 1.6MHz line rate. Scanning along the fast axis is performed with a 2.7 kHz or 4.3 kHz resonant scanner operated in bidirectional scanning mode, while a standard galvo scanner is used for the slow axis. The performance is analyzed with respect to various potential applications, like intraoperative OCT.},
keywords = {Optical coherence tomography, OCT, tunable laser, Fourier domain mode locking, FDML, MHz-OCT},
year = {2015},
doi = {10.1117/12.2183768},
URL = {https://doi.org/10.1117/12.2183768}
}

@inproceedings{10.1117/12.2077147,
author = {Jan Philip Kolb and Thomas Klein and Wolfgang Wieser and Wolfgang Draxinger and Robert Huber},
title = {{Full volumetric video rate OCT of the posterior eye with up to 195.2 volumes/s}},
volume = {9312},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX},
editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {931202},
abstract = {Full volumetric high speed OCT imaging of the retina with multiple settings varying in volume size and volume rate is
presented. The volume size ranges from 255x255 A-scans to 160x40 A-scans with 450 samples per depth scan. The
volume rates vary between 20.8 V/s for the largest volumes to 195.2 V/s for the smallest. The system is based on a
1060nm Fourier domain mode locked (FDML) laser with 1.6MHz line rate. Scanning along the fast axis is performed
with a 2.7 kHz or 4.3 kHz resonant scanner operated in bidirectional scanning mode, while a standard galvo scanner is
used for the slow axis. The performance is analyzed with respect to various potential applications, like intraoperative
OCT.},
keywords = {Optical coherence tomography, OCT, tunable laser, Fourier domain mode lockng, FDML, MHz OCT},
year = {2015},
doi = {10.1117/12.2077147},
URL = {https://doi.org/10.1117/12.2077147}
}

@inproceedings{10.1117/12.2183431,
author = {Wolfgang Wieser and Thomas Klein and Wolfgang Draxinger and Robert Huber},
title = {{Fully automated 1.5 MHz FDML laser with more than 100mW output power at 1310 nm}},
volume = {9541},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media},
editor = {Brett E. Bouma and Maciej Wojtkowski},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {954116},
abstract = {While FDML lasers with MHz sweep speeds have been presented five years ago, these devices have required manual control for startup and operation. Here, we present a fully self-starting and continuously regulated FDML laser with a sweep rate of 1.5 MHz. The laser operates over a sweep range of 115 nm centered at 1315 nm, and provides very high average output power of more than 100 mW. We characterize the laser performance, roll-off, coherence length and investigate the wavelength and phase stability of the laser output under changing environmental conditions. The high output power allows optical coherence tomography (OCT) imaging with an OCT sensitivity of 108 dB at 1.5 MHz.},
keywords = {OCT, optical coherence tomography, swept laser, wavelength-swept laser, fiber laser, MHz-OCT, Fourier-domain mode-locking, FDML},
year = {2015},
doi = {10.1117/12.2183431},
URL = {https://doi.org/10.1117/12.2183431}
}

@inproceedings{10.1117/12.2183859,
author = {Sebastian Karpf and Matthias Eibl and Wolfgang Wieser and Thomas Klein and Robert Huber},
title = {{Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers}},
volume = {9541},
booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media},
editor = {Brett E. Bouma and Maciej Wojtkowski},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {95410F},
abstract = {We present a new concept for performing stimulated Raman spectroscopy and microscopy by employing rapidly wavelength swept Fourier Domain Mode locked (FDML) lasers [1]. FDML lasers are known for fastest imaging in swept-source optical coherence tomography [2, 3]. We employ this continuous and repetitive wavelength sweep to generate broadband, high resolution stimulated Raman spectra with a new, time-encoded (TICO) concept [4]. This allows for encoding and detecting the stimulated Raman gain on the FDML laser intensity directly in time. Therefore we use actively modulated pump lasers, which are electronically synchronized to the FDML laser, in combination with a fast analog-to-digital converter (ADC) at 1.8 GSamples/s. We present hyperspectral Raman images with color-coded, molecular contrast.},
keywords = {swept lasers, FDML, TICO-Raman, fiber lasers, stimulated Raman microscopy, Raman spectroscopy, molecular contrast, multi-modal imaging},
year = {2015},
doi = {10.1117/12.2183859},
URL = {https://doi.org/10.1117/12.2183859}
}

@inproceedings{10.1117/12.2183854,
author = {Sebastian Karpf and Matthias Eibl and Robert Huber},
title = {{Nanosecond two-photon excitation fluorescence imaging with a multi color fiber MOPA laser}},
volume = {9536},
booktitle = {Advanced Microscopy Techniques IV; and Neurophotonics II},
editor = {Emmanuel Beaurepaire and Peter T. C. So and Francesco Pavone and Elizabeth M. Hillman},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {953616},
abstract = {A system is presented that uses a fiber based Master Oscillator Power Amplifier (MOPA) with nanosecond-range pulses for two-photon excitation fluorescence (TPEF) imaging. The robust laser in the extended near infrared is based on an actively modulated electro-optical modulator (EOM), enabling free synchronization of the pulses to any other light source or detection unit. Pulses with a freely programmable duration between 0.4 and 10 ns are generated and then amplified to up to kilowatts of peak power with ytterbium doped fiber amplifiers (YDFA). Since we achieve peak power and duty cycles comparable to standard femto- and picosecond setups, the TPEF signal levels are similar, but realized with a robust and inexpensive fiber-based setup. The delivery fiber is further used as an optional, electronically controllable Raman shifter to effectively shift the 1064 nm light to 1122 nm and to 1186 nm. This allows imaging of a manifold of fluorophores, like e.g. TexasRed, mCherry, mRaspberry and many more. We show TPEF imaging of the autofluorescence of plant leaves of moss and algae, acquired in epi-direction. This modular laser unit can be integrated into existing systems as either a fiber-based, alignment free excitation laser or an extension for multi-modal imaging.},
keywords = {multi-photon imaging, TPEF, MOPA, TPA, fiber laser, Raman shifter, non-linear imaging, multi-modal imaging},
year = {2015},
doi = {10.1117/12.2183854},
URL = {https://doi.org/10.1117/12.2183854}
}

@inproceedings{10.1117/12.2214788,
author = {Tom Pfeiffer and Wolfgang Wieser and Thomas Klein and Markus Petermann and Jan-Phillip Kolb and Matthias Eibl and Robert Huber},
title = {{Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging}},
volume = {9697},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX},
editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {96970S},
abstract = {In order to realize fast OCT-systems with adjustable line rate, we investigate averaging of image data from an FDML based
MHz-OCT-system. The line rate can be reduced in software and traded in for increased system sensitivity and image
quality. We compare coherent and incoherent averaging to effectively scale down the system speed of a 3.2 MHz FDML
OCT system to around 100 kHz in postprocessing. We demonstrate that coherent averaging is possible with MHz systems
without special interferometer designs or digital phase stabilisation. We show OCT images of a human finger knuckle joint
in vivo with very high quality and deep penetration.},
keywords = {Optical coherence tomography, OCT, Fourier domain mode locking, FDML, MHz OCT, averaging, tunable laser},
year = {2016},
doi = {10.1117/12.2214788},
URL = {https://doi.org/10.1117/12.2214788}
}

@inproceedings{Karpf:14,
author = {Sebastian Karpf and Matthias Eibl and Wolfgang Wieser and Thomas Klein and Robert Huber},
booktitle = {CLEO: 2014},
journal = {CLEO: 2014},
keywords = {Lasers, tunable; Scattering, stimulated Raman; Raman microscopy; Biological imaging; Medical imaging; Optical coherence tomography; Raman microscopy; Raman scattering; Swept lasers},
pages = {SM3P.3},
publisher = {Optica Publishing Group},
title = {Hyperspectral Stimulated Raman Microscopy with Fiber-based, Rapidly Wavelength Swept cw-Lasers},
year = {2014},
url = {https://opg.optica.org/abstract.cfm?URI=CLEO_SI-2014-SM3P.3},
doi = {10.1364/CLEO_SI.2014.SM3P.3},
abstract = {A hyperspectral stimulated Raman microscopy system using rapidly wavelength swept lasers is presented. Imaging of biological samples with shot noise limited detection is demonstrated with the fiber based setup.},
}

@inproceedings{Eibl:14,
author = {Matthias Eibl and Sebastian Karpf and Wolfgang Wieser and Thomas Klein and Robert Huber},
booktitle = {CLEO: 2014},
journal = {CLEO: 2014},
keywords = {Lasers, tunable; Scattering, stimulated Raman; Spectroscopy, Raman; Laser light; Laser sources; Master oscillator power amplifiers; Raman spectroscopy; Self phase modulation; Stimulated Raman scattering},
pages = {ATu3P.4},
publisher = {Optica Publishing Group},
title = {Broadband, High Resolution Stimulated Raman Spectroscopy with Rapidly Wavelength Swept cw-Lasers},
year = {2014},
url = {https://opg.optica.org/abstract.cfm?URI=CLEO_AT-2014-ATu3P.4},
doi = {10.1364/CLEO_AT.2014.ATu3P.4},
abstract = {A fast all fiber based setup for stimulated Raman spectroscopy with a rapidly wavelength swept cw-laser is presented. It enables flexible acquisition of broadband (750 cm{\textminus}1 to 3150 cm{\textminus}1) spectra with high resolution (0.5 cm{\textminus}1).},
}

@inproceedings{
   author = {Horstmann, J and Brinkmann, R},
   title = {Optical full-field holographic detection system for non-contact photoacoustic tomography},
   publisher = {Proc. SPIE},
year = {2014},
   type = {Conference Proceedings}
}

@inproceedings{10.1117/12.2033174,
author = {B. Olzowy and N. Starke and T. Schuldt and G. H{\"u}ttmann and E. Lankenau and T. Just},
title = {{Optical coherence tomography and confocal endomicroscopy for rhinologic pathologies: a pilot study}},
volume = {8805},
booktitle = {Head and Neck Optical Diagnostics},
editor = {Christian Betz and Brian J. F. Wong M.D.},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {880505},
keywords = {optical coherence tomography, confocal microscopy, inverted papilloma , chronic rhinosinusitis, nasal polyps, mucociliary function, ciliated epithelium},
year = {2013},
doi = {10.1117/12.2033174},
URL = {https://doi.org/10.1117/12.2033174}
}

@inproceedings{10.1117/12.2006979,
author = {Yaokun Zhang and Tom Pfeiffer and Wolfgang Wieser and Marcel Weller and Robert Huber and Thomas Klenzner and J{\"o}rg Raczkowsky and Heinz W{\"o}rn},
title = {{History compounding: a novel speckle reduction technique for OCT guided cochleostomy}},
volume = {8571},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII},
editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {85713H},
abstract = {Optical coherence tomography (OCT) is a promising candidate for monitoring the bottom of the drilled channel during
cochleostomy to prevent injury to the critical structure under the bone tissue. While the thickness of the overlaying bone
tissue is changed during the drilling process, the wave front of the backscattered light is also altered, resulting in
changing speckle patterns of the observed structures in the sequential historical scans. By averaging the different patterns
in these scans, named history compounding, the speckles can be reduced and the detection of critical structure becomes
much easier. Before averaging, the refractive index of bone tissue ???????? has to be compensated so that the speckles of the
same structure in different historical scans can be aligned together. An accurate method for measuring the refractive
index n<sub>b</sub> using OCT is presented. Experiments were conducted to evaluate history compounding and the new technique
is proved to be an effective, flexible and intuitive speckle reduction technique for OCT guided cochleostomy as well as
hard tissue ablation of other kind.},
keywords = {optical coherence tomography, speckle reduction, refractive index, cochleostomy, hard tissue ablation},
year = {2013},
doi = {10.1117/12.2006979},
URL = {https://doi.org/10.1117/12.2006979}
}

@INPROCEEDINGS{6801995,
  author={Karpf, Sebastian and Eibl, Matthias and Wieser, Wolfgang and Klein, Thomas and Huber, Robert},
  booktitle={2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC}, 
  title={FDML Raman: New high resolution SRS with ultra broadband spectral coverage}, 
  year={2013},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEOE-IQEC.2013.6801995}}

@inproceedings{Karpf:13,
author = {Sebastian Karpf and Matthias Eibl and Wolfgang Wieser and Thomas Klein and Robert Huber},
booktitle = {CLEO: 2013},
journal = {CLEO: 2013},
keywords = {Lasers, fiber; Scattering, stimulated Raman; Spectroscopy, Raman; Fourier domain mode locking; Lasers; Optical coherence tomography; Raman lasers; Raman spectroscopy; Swept lasers},
pages = {CTu2H.5},
publisher = {Optica Publishing Group},
title = {FDML Raman: High Speed, High Resolution Stimulated Raman Spectroscopy with Rapidly Wavelength Swept Lasers},
year = {2013},
url = {https://opg.optica.org/abstract.cfm?URI=CLEO_SI-2013-CTu2H.5},
doi = {10.1364/CLEO_SI.2013.CTu2H.5},
abstract = {An all fiber based system for high speed, high resolution Raman sensing is presented. The system is based on a wavelength swept Fourier Domain Mode Locked (FDML) laser for the detection of the Raman signal.},
}

@inproceedings{Fleischhauer2013,
   author = {Fleischhauer, Felix and Schulz-Hildebrandt, Hinnerk and Bonin, Tim and Hüttmann, Gereon},
   title = {Polarization-sensitive optical coherence tomography on different tissues samples for tumor discrimination},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
url = { https://pdfs.semanticscholar.org/a581/a18366acff021e12dcc090b40890ea70dcb8.pdf},
 year = { 2013}
}

@inproceedings{Seifert2013,
   author = {Seifert, Eric and Roh, Young-Jung and Fritz, Andreas and Park, Young Gun and Kang, Seungbum and Theisen-Kunde, Dirk and Brinkmann, Ralf},
   title = {Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model},
   volume = {8803},
   pages = {880303-880303-6},
year = {2013},
   note = {10.1117/12.2033560},
   abstract = {Selective Retina Therapy (SRT) targets the Retinal Pigment Epithelium (RPE) without effecting neighboring layers as the photoreceptors or the choroid. SRT related RPE defects are ophthalmoscopically invisible. Owing to this invisibility and the variation of the threshold radiant exposure for RPE damage the treating physician does not know whether the treatment was successful or not. Thus measurement techniques enabling a correct dosing are a demanded element in SRT devices. The acquired signal can be used for monitoring or automatic irradiation control. Existing monitoring techniques are based on the detection of micro-bubbles. These bubbles are the origin of RPE cell damage for pulse durations in the ns and μs time regime 5μs. The detection can be performed by optical or acoustical approaches. Monitoring based on an acoustical approach has already been used to study the beneficial effects of SRT on diabetic macula edema and central serous retinopathy. We have developed a first real time feedback technique able to detect micro-bubble induced characteristics in the backscattered laser light fast enough to cease the laser irradiation within a burst. Therefore the laser energy within a burst of at most 30 pulses is increased linearly with every pulse. The laser irradiation is ceased as soon as micro-bubbles are detected. With this automatic approach it was possible to observe invisible lesions, an intact photoreceptor layer and a reconstruction of the RPE within one week.},
   url = {http://dx.doi.org/10.1117/12.2033560},
   type = {Conference Proceedings}
}

@inproceedings{Sudkamp2013,
   author = {Sudkamp, Helge and Lee, H Y and Hüttmann, Gereon and Kellerbee, A K},
   title = {An approach to increase the speed of Optical Coherence Tomography using a Virtually Imaged Phased Array},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
year= { 2013}
}

@inproceedings{Oepen2013,
   author = {van Oepen, Alexander and Horstmann, Jens and Brinkmann, Ralf},
   title = {Characterization of an Electronic Speckle Pattern Detection System},
   booktitle = {Studierendentagung},
   type = {Conference Proceedings}
}