Publikationen

2019

  • Liang, X-X; Zhang, Z and Vogel, A: Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water. Opt Expr 27(4), pp. 672-4693, 2019
    BibTeX Link
    @article{Liang2019,
       author = {Liang, X-X; Zhang, Z and Vogel, A},
       title = {Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water},
       journal = {Opt Expr} { 27(4)},
       
       
       pages = {4672-4693}
       DOI = {10.1364/OE.27.004672}
       
       year = {2019},
       type = {Journal Article}
    }
    
  • Freidank, S;Vogel, A;Anderson, R. R.;Birngruber, R and Linz, N: Correction of hyperopia by intrastromal cutting and liquid filler injection. J Biomed Opt 24 (5), pp. 1-7, 7, 2019
    BibTeX Link
    @article{Freidank2019,
       author = {Freidank, S;Vogel, A;Anderson, R. R.;Birngruber, R and Linz, N},
       title = {Correction of hyperopia by intrastromal cutting and liquid filler injection},
       journal = {J Biomed Opt} {24 (5)},
      
       number = {5 %J Journal of Biomedical Optics},
       pages = {1-7, 7},
       
       url = {https://doi.org/10.1117/1.JBO.24.5.058001},
       year = {2019},
       type = {Journal Article}
    }
    

2016

  • Linz, Norbert and Freidank, Sebastian and Liang, Xiao-Xuan and Vogel, Alfred: Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery. American Physical Society,Phys. Rev. B, no. 94, pp. 1-19, 2016
    BibTeX Link
    @article{Linz2016,
       author = {Linz, Norbert and Freidank, Sebastian and Liang, Xiao-Xuan and Vogel, Alfred},
       title = {Wavelength dependence of femtosecond laser-induced breakdown in water and implications for laser surgery},
       journal = {American Physical Society,Phys. Rev. B},
       volume = { 94},
       number = {2},
       pages = {1-19},
       url = {http://link.aps.org/doi/10.1103/PhysRevB.94.024113},
       year = {2016},
       type = {Journal Article}
    }
    
  • Wang, S. and Huttmann, G. and Scholzen, T. and Zhang, Z. and Vogel, A. and Hasan, T. and Rahmanzadeh, R.: A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67. Sci Rep, no. 6, pp. 27032, 2016
    BibTeX Link
    @article{Wang2016,
       author = {Wang, S. and Huttmann, G. and Scholzen, T. and Zhang, Z. and Vogel, A. and Hasan, T. and Rahmanzadeh, R.},
       title = {A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67},
       journal = {Sci Rep},
       volume = {6},
       pages = {27032},
       note = {2045-2322
    Wang, Sijia
    Huttmann, Gereon
    Scholzen, Thomas
    Zhang, Zhenxi
    Vogel, Alfred
    Hasan, Tayyaba
    Rahmanzadeh, Ramtin
    Journal Article
    England
    Sci Rep. 2016 Jun 1;6:27032. doi: 10.1038/srep27032.},
       abstract = {Using nanotechnology for optical manipulation of molecular processes in cells with high spatial and temporal precision promises new therapeutic options. Especially tumor therapy may profit as it requires a combination of both selectivity and an effective cell killing mechanism. Here we show a dual targeting approach for selective and efficient light-controlled killing of cells which are positive for epidermal growth factor receptor (EGFR) and Ki-67. Liposomes with the covalently linked EGFR antibody Erbitux enabled selective uptake of FITC-labeled Ki-67 antibody TuBB-9 in EGFR-positive cells pre-loaded with the photoactive dye BPD. After irradiation at 690 nm, BPD disrupted the endosomal membranes and delivered the antibodies to the nucleoli of the cells. The second irradiation at 490 nm activated the FITC-labeled TuBB-9, which caused inactivation of the Ki-67 protein and subsequent cell death via apoptosis. Efficient cell killing was possible at nanomolar concentrations of TuBB-9 due to the effective transport by immune liposomes and the high efficacy of the Ki-67 light-inactivation. Delivery of the liposomal constructs and cell destruction correlated well with the EGFR expression pattern of different cell lines (HeLa, OVCAR-5, MCF-7, and human fibroblasts), demonstrating an excellent selectivity.},
       ISSN = {2045-2322},
       DOI = {10.1038/srep27032},
       year = {2016},
       type = {Journal Article}
    }
    

2015

  • Linz, Norbert and Freidank, Sebastian and Liang, Xiao-Xuan and Vogelmann, Hannes and Trickl, Thomas and Vogel, Alfred: Wavelength dependence of nanosecond infrared laser-induced breakdown in water: Evidence for multiphoton initiation via an intermediate state. Physical Review B, no. 91, pp. 134114, 2015
    BibTeX Link
    @article{Linz2015,
       author = {Linz, Norbert and Freidank, Sebastian and Liang, Xiao-Xuan and Vogelmann, Hannes and Trickl, Thomas and Vogel, Alfred},
       title = {Wavelength dependence of nanosecond infrared laser-induced breakdown in water: Evidence for multiphoton initiation via an intermediate state},
       journal = {Physical Review B},
       volume = {91},
       number = {13},
       pages = {134114},
       note = {PRB},
       DOI = {doi/10.1103/PhysRevB.91.134114},
       url = {http://link.aps.org/doi/10.1103/PhysRevB.91.134114},
       year = {2015},
       type = {Journal Article}
    }
    
  • Wang, S. and Huttmann, G. and Zhang, Z. and Vogel, A. and Birngruber, R. and Tangutoori, S. and Hasan, T. and Rahmanzadeh, R.: Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67. Mol Pharm, 2015
    BibTeX Link
    @article{Wang2015,
       author = {Wang, S. and Huttmann, G. and Zhang, Z. and Vogel, A. and Birngruber, R. and Tangutoori, S. and Hasan, T. and Rahmanzadeh, R.},
       title = {Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67},
       journal = {Mol Pharm},
       note = {1543-8392
    Wang, Sijia
    Huttmann, Gereon
    Zhang, Zhenxi
    Vogel, Alfred
    Birngruber, Reginald
    Tangutoori, Shifalika
    Hasan, Tayyaba
    Rahmanzadeh, Ramtin
    Journal article
    Mol Pharm. 2015 Aug 13.},
       abstract = {The selective inhibition of intracellular and nuclear molecules such as Ki-67 holds great promise for the treatment of cancer and other diseases. However, the choice of the target protein and the intracellular delivery of the functional agent remain crucial challenges. Main hurdles are (a) an effective delivery into cells, (b) endosomal escape of the delivered agents, and (c) an effective, externally triggered destruction of cells. Here we show a light-controlled two-step approach for selective cellular delivery and cell elimination of proliferating cells. Three different cell-penetrating nano constructs, including liposomes, conjugates with the nuclear localization sequence (NLS), and conjugates with the cell penetrating peptide Pep-1, delivered the light activatable antibody conjugate TuBB-9-FITC, which targets the proliferation associated protein Ki-67. HeLa cells were treated with the photosensitizer benzoporphyrin monoacid derivative (BPD) and the antibody constructs. In the first optically controlled step, activation of BPD at 690 nm triggered a controlled endosomal escape of the TuBB-9-FITC constructs. In more than 75% of Ki-67 positive, irradiated cells TuBB-9-FITC antibodies relocated within 24 h from cytoplasmic organelles to the cell nucleus and bound to Ki-67. After a second light irradiation at 490 nm, which activated FITC, cell viability decreased to approximately 13%. Our study shows an effective targeting strategy, which uses light-controlled endosomal escape and the light inactivation of Ki-67 for cell elimination. The fact that liposomal or peptide-assisted delivery give similar results leads to the additional conclusion that an effective mechanism for endosomal escape leaves greater variability for the choice of the delivery agent.},
       keywords = {endosomal entrapment
    liposome
    nanotechnology
    nuclear localization sequence (NLS)
    photodynamic therapy},
       ISSN = {1543-8384},
       DOI = {10.1021/acs.molpharmaceut.5b00260},
       year = {2015},
       type = {Journal Article}
    }
    
  • Klinger, A. and Krapf, L. and Orzekowsky-Schroeder, R. and Koop, N. and Vogel, A. and Huttmann, G.: Intravital autofluorescence 2-photon microscopy of murine intestinal mucosa with ultra-broadband femtosecond laser pulse excitation: image quality, photodamage, and inflammation. J Biomed Opt, no. 20, pp. 116001, 2015
    BibTeX Link
    @article{Klinger2017,
       author = {Klinger, A. and Krapf, L. and Orzekowsky-Schroeder, R. and Koop, N. and Vogel, A. and Huttmann, G.},
       title = {Intravital autofluorescence 2-photon microscopy of murine intestinal mucosa with ultra-broadband femtosecond laser pulse excitation: image quality, photodamage, and inflammation},
       journal = {J Biomed Opt},
       volume = {20},
       number = {11},
       pages = {116001},
       ISSN = {1083-3668},
       DOI = {10.1117/1.jbo.20.11.116001},
       year = {2015},
       type = {Journal Article}
    }
    
  • Han, Bing and Köhler, Karsten and Jungnickel, Kerstin and Mettin, Robert and Lauterborn, Werner and Vogel, Alfred: Dynamics of laser-induced bubble pairs. Journal of Fluid Mechanics, no. 771, pp. 706-742, 2015
    BibTeX Link
    @article{Han2015,
       author = {Han, Bing and Köhler, Karsten and Jungnickel, Kerstin and Mettin, Robert and Lauterborn, Werner and Vogel, Alfred},
       title = {Dynamics of laser-induced bubble pairs},
       journal = {Journal of Fluid Mechanics},
       volume = {771},
       pages = {706-742},
       keywords = {bubble dynamics,cavitation,jets},
       ISSN = {1469-7645},
       DOI = {doi:10.1017/jfm.2015.183},
       url = {http://dx.doi.org/10.1017/jfm.2015.183},
       year = {2015},
       type = {Journal Article}
    }
    

2014

  • Vogel, A and Freidank, S and Linz, N: Alternativen zur Femtosekundentechnologie: UV Subnanosekunden-pulse und Ringfoki für LASIK Flaperzeugung (at press). Ophthalomologe, no. 111, 2014
    BibTeX
    @article{Vogel2014,
       author = {Vogel, A and Freidank, S and Linz, N },
       title = {Alternativen zur Femtosekundentechnologie: UV Subnanosekunden-pulse und Ringfoki für LASIK Flaperzeugung (at press)},
       journal = {Ophthalomologe },
       volume = {111},
       number = {6},
       year = {2014},
       type = {Journal Article}
    }
    

2013

  • Lauterborn, Werner and Vogel, Alfred: Shock Wave Emission by Laser Generated Bubbles. in Bubble Dynamics and Shock Waves, pp. 67-103, 2013
    BibTeX
    @inbook{Lauterborn2013,
       author = {Lauterborn, Werner and Vogel, Alfred},
       title = {Shock Wave Emission by Laser Generated Bubbles},
       booktitle = {Bubble Dynamics and Shock Waves},
       pages = {67-103},
       year = {2013}
    }
    
  • Trost, Andrea and Schroedl, Falk and Strohmaier, Clemens A and Bogner, Barbara and Runge, Christian and Kaser-Eichberger, Alexandra and Krefft, Karolina Anna and Vogel, Alfred and Linz, Norbert and Freidank, Sebastian and Hilpert, Andrea and Zimmermann, Inge and Grabner, Günther and Reitsamer, Herbert A: A new nanosecond UV-laser at 355 nm: early results of corneal flap cutting in a rabbit model. Investigative Ophthalmology & Visual Science, 2013
    BibTeX Link
    @article{Trost2013,
       author = {Trost, Andrea and Schroedl, Falk and Strohmaier, Clemens A and Bogner, Barbara and Runge, Christian and Kaser-Eichberger, Alexandra and Krefft, Karolina Anna and Vogel, Alfred and Linz, Norbert and Freidank, Sebastian and Hilpert, Andrea and Zimmermann, Inge and Grabner, Günther and Reitsamer, Herbert A},
       title = {A new nanosecond UV-laser at 355 nm: early results of corneal flap cutting in a rabbit model},
       journal = {Investigative Ophthalmology & Visual Science},
       abstract = {Purpose: A new 355nm UV laser was used for corneal flap cutting in an animal model and tested for clinical and morphological alterations. Methods: Corneal flaps were created (Chinchilla Bastards; n=25) with an UV-nanosecond laser at 355nm (150kHz, pulse duration 850ps, spot-size 1µm, spot-spacing 6x6µm, side-cut Δz 1µm; cutting depth 130µm) and pulse energies of 2.2 or 2.5µJ, respectively. Following slit lamp examination, animals were sacrificed at 6, 12 and 24hrs after treatment. Corneas were prepared for histology (HE, TUNEL-assay) and evaluated statistically, followed by ultrastructural investigations. Results: Laser treatment was tolerated well, flap lift was easier at 2.5µJ compared to 2.2µJ. Standard HE at 24hrs revealed intact epithelium in the horizontal cut, with similar increase in corneal thickness at both energies. Irrespective of energy levels, TUNEL assay revealed comparable numbers of apoptotic cells in the horizontal and vertical cut at 6/12/24hrs, becoming detectable in the horizontal cut as an acellular stromal band at 24hrs. Ultrastructural analysis revealed regular morphology in the epi- and endothelium, while in the stroma, disorganized collagen lamellae were detectable representing the horizontal cut, again irrespective of energy levels applied. Conclusions:This new UV-laser revealed no epithelial nor endothelial damage at energies feasible for corneal flap cutting. Observed corneal swelling was lower compared to existing UV-lasers-studies, albeit total energy applied here was much higher. Observed loss of stromal keratinocytes is comparable to available laser systems. Therefore, this new laser is suitable for refractive surgery, awaiting its test in a chronic environment.},
       DOI = {10.1167/iovs.13-12580},
       url = {http://www.iovs.org/content/early/2013/10/28/iovs.13-12580.abstract},
       year = {2013},
       type = {Journal Article}
    }
    

2011

  • Vogel, A and Venugopalan, V.: Pulsed laser ablation of tissue. Springer, Heidelberg, New York, 2011
    BibTeX
    @book{Vogel,
       author = {Vogel, A and Venugopalan, V.},
       title = {Pulsed laser ablation of tissue},
       publisher = {Springer, Heidelberg, New York},
       edition = {2},
       year = {2011}
    }
  • Vogel, Alfred and Venugopalan, Vasan: Pulsed Laser Ablation of Soft Biological Tissues. in Optical-Thermal Response of Laser-Irradiated Tissue, pp. 551-615, 2011
    BibTeX
    @inbook{Vogel,
       author = {Vogel, Alfred and Venugopalan, Vasan},
       title = {Pulsed Laser Ablation of Soft Biological Tissues},
       booktitle = {Optical-Thermal Response of Laser-Irradiated Tissue},
       pages = {551-615},
       year = {2011}
    }
    
  • Orzekowsky-Schroeder, Regina and Klinger, Antje and Martensen, Bjorn and Blessenohl, Maike and Gebert, Andreas and Vogel, Alfred and Huttmann, Gereon: In vivo spectral imaging of different cell types in the small intestine by two-photon excited autofluorescence. Journal of Biomedical Optics, no. 16, pp. 116025, 2011
    BibTeX
    @article{Orzekowsky2011,
       author = {Orzekowsky-Schroeder, Regina and Klinger, Antje and Martensen, Bjorn and Blessenohl, Maike and Gebert, Andreas and Vogel, Alfred and Huttmann, Gereon},
       title = {In vivo spectral imaging of different cell types in the small intestine by two-photon excited autofluorescence},
       journal = {Journal of Biomedical Optics},
       volume = {16},
       number = {11},
       pages = {116025},
       keywords = {biological organs
    biomedical optical imaging
    cellular biophysics
    fluorescence
    laser applications in medicine
    two-photon processes},
       year = {2011}
    }

2009

  • Lachmann, Kristina and Eckert, Sebastian and Vogel, Alfred and Klinger, Antje and Gebert, Andreas and Klages, Claus-Peter: Development of a multifunctional coating system for laser-induced material transport. Progress in Organic Coatings, no. 64, pp. 294-299, 2009
    BibTeX
    @article{Lachmann,
       author = {Lachmann, Kristina and Eckert, Sebastian and Vogel, Alfred and Klinger, Antje and Gebert, Andreas and Klages, Claus-Peter},
       title = {Development of a multifunctional coating system for laser-induced material transport},
       journal = {Progress in Organic Coatings},
       volume = {64},
       number = {2–3},
       pages = {294-299},
       abstract = {The aim of our research is to develop a novel surface coating for the use in laser microdissection and laser pressure catapulting (LMPC). LMPC is a contact- and contamination-free technique to separate histologic material and living cells for further proteomic and genomic analysis. Several physico-chemical functions must be included within the optimum coating system designed for this purpose, like optical absorption at the laser wavelength, combined with optical transparency in the visible region, a control of the laser ablation process, mechanical stability and biocompability for the adhesion of the histologic material. To achieve the optimum system the combination of several layers is required. The optical absorbance to capture the radiation energy from a frequency-tripled Nd:YAG laser (? = 355 nm) is reached by a thin layer of zinc oxide (ZnO), deposited by hollow cathode gas flow sputtering. The laser ablation process is controlled by a polyelectrolyte multilayer, consisting of poly(diallyldimethylammonium chloride) (PDADMAC) and poly(sodium 4-styrenesulfonate) (PSS). The evaporation of chemisorbed water from the film is used to promote the catapulting process. For the mechanically stable, laser-dissectible layer organic coatings, like photoresists or lacquers, are suitable. Silica-containing polyacrylate nanocomposites were employed for this purpose. The investigation of the coating system included LMPC experiments with varying compositions of the layer system. The best results were obtained using a system consisting of ZnO, a polyelectrolyte multilayer deposited from 0.1 M Na2SO4 containing polymer solutions, and a 1.5-?m thick layer of the polyacrylate nanocomposite. To check the quality of the developed system, experiments with the commonly used poly(ethylene naphthalate) (PEN) foil were performed simultaneously. In addition to the determination of the parameters required for LMPC, quantitative real-time Polymerase Chain Reaction (rt-PCR) of the dissected material verified the benefit of the new system.},
       keywords = {Laser microdissection
    Laser pressure catapulting
    Polyelectrolyte multilayer
    Laser ablation
    Zinc oxide},
       year = {2009}
    }

2008

  • Vogel, A. and Linz, N. and Freidank, S. and Paltauf, G.: Femtosecond-laser-induced nanocavitation in water: implications for optical breakdown threshold and cell surgery. no. 100, pp. 23, 2008
    BibTeX
    @misc{Vogel2008,
       author = {Vogel, A. and Linz, N. and Freidank, S. and Paltauf, G.},
       title = {Femtosecond-laser-induced nanocavitation in water: implications for optical breakdown threshold and cell surgery},
       volume = {100},
       number = {3},
       pages = {23},
       note = {Using Smart Source Parsing
    Jan 25;:038102. Epub 2008 Jan},
       abstract = {We determined the bubble radius R_(max) for femtosecond optical breakdown in water at 347, 520, and 1040 nm with an unprecedented accuracy (+/-10 nm). At threshold, R_(max) was smaller than the diffraction-limited focus radius and ranged from 190 nm to 320 nm. The increase of R_(max) with laser energy E_(L) is slowest at 347 nm, providing optimum control of cell surgery. Experimental results agree with a model of bubble formation in heated and thermoelastically stretched liquids. Theory predicts a threshold temperature T_(th) approximately equal to 168 degrees C. For T>300 degrees C, a phase explosion sets in, and R_(max) increases rapidly with E_(L).},
       ISBN = {0031-9007 (Print)
    0031-9007 (Linking)},
       year = {2008}
    }

2007

  • Horneffer, V. and Linz, N. and Vogel, A.: Principles of laser-induced separation and transport of living cells. J Biomed Opt, no. 12, pp. 054016, 2007
    BibTeX
    @article{Horneffer,
       author = {Horneffer, V. and Linz, N. and Vogel, A.},
       title = {Principles of laser-induced separation and transport of living cells},
       journal = {J Biomed Opt},
       volume = {12},
       number = {5},
       pages = {054016},
       note = {Horneffer, Verena
    Linz, Norbert
    Vogel, Alfred
    Evaluation Studies
    Research Support, Non-U.S. Gov't
    United States
    J Biomed Opt. 2007 Sep-Oct;12(5):054016.},
       abstract = {Separation and transport of defined populations of living cells grown on a thin membrane can be achieved by laser microdissection (LMD) of the sample of interest, followed by a laser-induced forward transport process [laser pressure "catapulting" (LPC)] of the dissected cell cluster. We investigate the dynamics of LMD and LPC with focused and defocused UV-A laser pulses by means of time-resolved photography. Catapulting is driven by plasma formation when tightly focused pulses are used, and by confined thermal ablation at the bottom of the sample for defocused catapulting. With both modalities, the initial specimen velocity amounts to about 50 to 60 ms. Time-resolved photography of live cell catapulting reveals that in defocused catapulting, strong shear forces arise when the sample is accelerated out of the culture medium covering the cells. By contrast, pulses focused at the periphery of the specimen cause a fast rotational movement that minimizes the flow of culture medium parallel to the sample surface, and thus the resulting shear stresses. Therefore, the recultivation rate of catapulted cells is much higher when focused pulses are used. Compared to collateral damage by mechanical forces, side effects by heat and UV exposure of the cells play only a minor role.},
       keywords = {Animals
    CHO Cells
    Cell Separation/ methods
    Cricetinae
    Cricetulus
    Microdissection/ methods
    Optical Tweezers
    Specimen Handling/ methods},
       year = {2007}
    }
  • Vogel, A and Horneffer, V. and Lorenz, B. and Linz, N. and Freidank, S. and Hüttmann, G. and Gebert, A.: Principles of laser microdissection and catapulting of histologic specimens and live cells. in Laser Manipulation of Cells and Tissues, Methods in Cell Biology, no. 82, pp. 153-205, Academic Press Elsevier, San Diego, 2007
    BibTeX
    @inbook{Vogel2007,
       author = {Vogel, A and Horneffer, V. and Lorenz, B. and Linz, N. and Freidank, S. and Hüttmann, G. and Gebert, A.},
       title = {Principles of laser microdissection and catapulting of histologic specimens and live cells},
       booktitle = {Laser Manipulation of Cells and Tissues, Methods in Cell Biology},
       editor = {Berns, M.  and Greulich, K.O.},
       publisher = {Academic Press Elsevier},
       address = {San Diego},
       volume = {82},
       pages = {153-205},
       year = {2007}
    }
  • Vogel, Alfred and Apitz, Ingo and Venugopalan, Vasan: Phase transitions, material ejection, and plume dynamics in pulsed laser ablation of soft biological tissues. in Oscillations, Waves and Interactions, T. Kurz, U. Parlitz, and U. Kaatze, eds.(Universitätsverlag Göttingen, Göttingen, 2007), pp. 217-258, 2007
    BibTeX
    @inbook{Vogel2007,
       author = {Vogel, Alfred and Apitz, Ingo and Venugopalan, Vasan},
       title = {Phase transitions, material ejection, and plume dynamics in pulsed laser ablation of soft biological tissues},
       booktitle = {Oscillations, Waves and Interactions, T. Kurz, U. Parlitz, and U. Kaatze, eds.(Universitätsverlag Göttingen, Göttingen, 2007)},
       pages = {217-258},
       year = {2007}
    }
    
  • Vogel, A and Apitz, I. and Venugopalan, V.: Phase transitions, material ejection, and plume dynamics in pulsed laser ablation of soft biological tissues. in Oscillations, Waves, and Interactions. Sixty Years Drittes Physikalisches Institut., no. A Festschrift, pp. 217-258, Universitätsverlag, Göttingen, 2007
    BibTeX
    @inbook{Vogel2007,
       author = {Vogel, A and Apitz, I. and Venugopalan, V.},
       title = {Phase transitions, material ejection, and plume dynamics in pulsed laser ablation of soft biological tissues},
       booktitle = {Oscillations, Waves, and Interactions. Sixty Years Drittes Physikalisches Institut.},
       editor = {Kurtz, T., Parlitz, U. and  Kaatze, U.},
       publisher = {Universitätsverlag},
       address = {Göttingen},
       volume = {A Festschrift},
       pages = {217-258},
       year = {2007}
    }
  • Vogel, A. and Lorenz, K. and Horneffer, V. and Hüttmann, G. and von Smolinski, D. and Gebert, A.: Mechanisms of laser-induced dissection and transport of histologic specimens.. Biophys J, no. 93, pp. 4481-4500, 2007
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Lorenz, K. and Horneffer, V. and Hüttmann, G. and von Smolinski, D. and Gebert, A.},
       title = {Mechanisms of laser-induced dissection and transport of histologic specimens.},
       journal = {Biophys J},
       volume = {93},
       pages = {4481-4500},
       year = {2007}
    }
  • Vogel, A; Lorenz, K; Horneffer, V; Hüttmann, G; Von Smolinski, D and Gebert, A: Mechanisms of laser-induced dissection and transport of histologic specimens. Biophys J 93(12), pp. 4481-4500, 2007
    BibTeX Link
    @article{Vogel2007,
       author = {Vogel, A; Lorenz, K; Horneffer, V; Hüttmann, G; Von Smolinski, D and Gebert, A},
       title = {Mechanisms of laser-induced dissection and transport of histologic specimens},
       journal = {Biophys J} {93(12)},
       url = {https://doi.org/10.1529/biophysj.106.102277},
       pages = {4481-4500},
       ISSN = {0006-3495},
       year = {2007},
       type = {Journal Article}
    }
    
  • Vogel, A and Noack, J. and Hüttmann, G. and Paltauf, G.: Mechanisms of femtosecond laser nanoprocessing of biological cells and tissues. in The Eigth International Conference on Laser Ablation (COLA 2005), no. 59, pp. 249-254, 2007
    BibTeX
    @inbook{Vogel2007,
       author = {Vogel, A and Noack, J. and Hüttmann, G. and Paltauf, G.},
       title = {Mechanisms of femtosecond laser nanoprocessing of biological cells and tissues},
       booktitle = {The Eigth International Conference on Laser Ablation (COLA 2005)},
       editor = {Herman, P. and Hess, W .},
       series = {Journal of Physics: Conference Series},
       volume = {59},
       pages = {249-254},
       year = {2007}
    }
  • Vogel, Alfred and Noack, Joachim and Hüttman, Gereon and Paltauf, Günther: Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues Laser Ablation and its Applications. no. 129, pp. 231-280, Springer Berlin / Heidelberg, 2007
    BibTeX
    @inbook{Vogel2007,
       author = {Vogel, Alfred and Noack, Joachim and Hüttman, Gereon and Paltauf, Günther},
       title = {Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues
    Laser Ablation and its Applications},
       editor = {Phipps, Claude},
       series = {Springer Series in Optical Sciences},
       publisher = {Springer Berlin / Heidelberg},
       volume = {129},
       pages = {231-280},
       keywords = {Physics and Astronomy},
       year = {2007}
    }
  • Vogel, Alfred and Noack, Joachim and Hüttman, Gereon and Paltauf, Günther: Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues. in Laser Ablation and Its Applications, no. 129, pp. 231-280, Springer US, 2007
    BibTeX
    @inbook{Vogel2007,
       author = {Vogel, Alfred and Noack, Joachim and Hüttman, Gereon and Paltauf, Günther},
       title = {Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues},
       booktitle = {Laser Ablation and Its Applications},
       editor = {Phipps, Claude},
       series = {Springer Series in Optical Sciences},
       publisher = {Springer US},
       volume = {129},
       chapter = {10},
       pages = {231-280},
       year = {2007}
    }
    
  • Vogel, A. and Noack, J. and Hüttmann, G. and Linz, N. and Freidank, S. and Paltauf, G.: Chapter 18 Femtosecond laser nanosurgery of biological cells and tissues. in Handai Nanophotonics, no. Volume 3, pp. 273-286, Elsevier, 2007
    BibTeX
    @inbook{Vogel2007,
       author = {Vogel, A. and Noack, J. and Hüttmann, G. and Linz, N. and Freidank, S. and Paltauf, G.},
       title = {Chapter 18 Femtosecond laser nanosurgery of biological cells and tissues},
       booktitle = {Handai Nanophotonics},
       editor = {Hiroshi Masuhara, Satoshi Kawata and Fumio, Tokunaga},
       publisher = {Elsevier},
       volume = {Volume 3},
       pages = {273-286},
       year = {2007}
    }

2006

  • Brujan, EA. and Vogel, A .: Stress wave emission and cavitation bubble dynamics by nanosecond optical breakdown in a tissue phantom.. J Fluid Mech, no. 558, pp. 281-308, 2006
    BibTeX
    @article{Brujan,
       author = {Brujan, EA. and Vogel, A .},
       title = {Stress wave emission and cavitation bubble dynamics by nanosecond optical breakdown in a tissue phantom.},
       journal = { J Fluid Mech},
       volume = {558},
       pages = {281-308},
       year = {2006}
    }
  • Vogel, A. and Apitz, I. and Freidank, S. and Dijkink, R.: Sensitive high-resolution white-light Schlieren technique with a large dynamic range for the investigation of ablation dynamics. Opt. Lett., no. 31, pp. 1812-1814, 2006
    BibTeX
    @article{Vogel2006,
       author = {Vogel, A. and Apitz, I. and Freidank, S. and Dijkink, R.},
       title = {Sensitive high-resolution white-light Schlieren technique with a large dynamic range for the investigation of ablation dynamics},
       journal = {Opt. Lett.},
       volume = {31},
       pages = {1812-1814},
       year = {2006}
    }
  • Hoerauf, H. and Brix, A. and Winkler, J. and Droege, G. and Winter, C. and Birngruber, R. and Laqua, H. and Vogel, A.: Photoablation of inner limiting membrane and inner retinal layers using the erbium : YAG-laser: An in vitro study. Lasers in Surgery and Medicine, no. 38, pp. 52-61, 2006
    BibTeX Link
    @article{Hoerauf2006,
       author = {Hoerauf, H. and Brix, A. and Winkler, J. and Droege, G. and Winter, C. and Birngruber, R. and Laqua, H. and Vogel, A.},
       title = {Photoablation of inner limiting membrane and inner retinal layers using the erbium : YAG-laser: An in vitro study},
       journal = {Lasers in Surgery and Medicine},
       volume = {38},
       number = {1},
       pages = {52-61},
       note = {009YN
    Times Cited:4
    Cited References Count:51},
       abstract = {Background and Objectives: To explore the potential of Er:YAG-laser irradiation for precise and tractionless retinal tissue and inner limiting membrane ablation.
    Materials and Methods: We used free-running Er:YAG-laser irradiation (lambda = 2.94 mu m) transmitted either through a 10 em long low-OH-quartz fiber or a 2 m long sapphire fiber that produced a more homogenous light distribution at the fiber tip. Retinal ablation in porcine retinal explants was performed under air or perfluorodecaline (PFD). Ablation depth was evaluated by optical coherence tomography (OCT) and from histologic sections.
    Results: A radiant exposure of 5.0 J/cm(2) delivered through a low-OH-quartz fiber and PFD caused a complete transsection of the neurosensory retina. Radiant exposures between 3.5 and 2.0 J/cm(2) resulted in marked variations of ablation depth and adjacent thermal damage. By contrast, laser pulses of 4.0 and 3.0 J/cm(2) transmitted through the sapphire fiber produced more homogenous defect patterns and less thermal damage. Close to the ablation threshold, with 1.0-2.0 J/cm(2), ablation was limited to a 10-20 mu m thin layer of the neural retina.
    Conclusions: We achieved in vitro ablation of inner retinal layers, but could not produce selective and reproducible ILM removal.},
       keywords = {macular surgery
    optical coherence tomography
    perfluorocarbon liquid
    retina
    retinal explant
    optical coherence tomography
    macular hole surgery
    experimental vitreous membranes
    er-yag
    vitreoretinal surgery
    clinical-experience
    indocyanine green
    excimer-laser
    pig eyes
    ablation},
       ISSN = {0196-8092},
       DOI = {Doi 10.1002/Lsm.20269},
       url = {<Go to ISI>://WOS:000235149600007},
       year = {2006},
       type = {Journal Article}
    }
    
  • Vogel, A. and Noack, J and Hüttmann, G. and Paltauf, G.: Femtosecond plasma-mediated nanosurgery of cells and tissues.. in Laser Ablation, pp. 217-262, Springer, Heidelberg, 2006
    BibTeX
    @inbook{Vogel2006,
       author = {Vogel, A. and Noack, J and Hüttmann, G. and Paltauf, G.},
       title = {Femtosecond plasma-mediated nanosurgery of cells and tissues.},
       booktitle = {Laser Ablation},
       editor = {), Phipps C (Hrsg.},
       publisher = { Springer, Heidelberg},
       pages = {217-262},
       year = {2006}
    }

2005

  • Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.: Mechanisms of femtosecond laser nanosurgery of biological cells and tissues. Appl. Phys B, no. 81, pp. 1015-1047, 2005
    BibTeX
    @article{Vogel2005,
       author = {Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.},
       title = {Mechanisms of femtosecond laser nanosurgery of biological cells and tissues},
       journal = {Appl. Phys B},
       volume = {81},
       pages = {1015-1047},
       year = {2005}
    }
  • Apitz, I. and Vogel, A.: Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin. Applied Physics A: Materials Science & Processing, no. 81, pp. 329-338, 2005
    BibTeX
    @article{Apitz,
       author = {Apitz, I. and Vogel, A.},
       title = {Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin},
       journal = {Applied Physics A: Materials Science & Processing},
       volume = {81},
       number = {2},
       pages = {329-338},
       abstract = {We investigated the mechanisms of material ejection in Q-switched Er:YAG laser tissue ablation (70-ns pulse duration) where moderate and large radiant exposures are associated with large volumetric energy densities in the target material. For water, an initial phase of non-equilibrium surface vaporization is followed by an explosive vaporization of the superficial liquid volume from a supercritical state. The ablation of deeper layers with lower peak temperatures proceeds as phase explosion. For mechanically strong tissues, non-equilibrium surface vaporization is followed by a vapour explosion coupled with thermal dissociation of the biomolecules into volatile products. In deeper layers, ablation proceeds as confined boiling with mechanical tearing of the tissue matrix by the vapour pressure. The recoil stress induced at a radiant exposure of 5.4 J/cm 2 is in the order of 500–900 MPa. For water and soft tissues such as liver, the recoil causes a powerful secondary material expulsion. For stronger tissues such as skin, no secondary expulsion was observed even though the recoil stress largely exceeds the static tensile strength of the tissue. Recoil-induced material expulsion results in an increase of both ablation efficiency and mechanical side effects of ablation. Theoretical modelling of the succession of phase transitions in nanosecond-laser tissue ablation and of recoil-induced material expulsion remain a major challenge for future work.},
       keywords = {Physik und Astronomie},
       year = {2005}
    }
  • Vogel, A and Lorenz, B. and Sägmüller, B. and Schütze, K.: Catapulting of microdissected histologic specimens with focused and defocused laser pulses. Optical Society of America, 2005
    BibTeX
    @article{Vogel,
       author = {Vogel, A and Lorenz, B. and Sägmüller, B. and Schütze, K.},
       title = {Catapulting of microdissected histologic specimens with focused and defocused laser pulses},
       journal = {Optical Society of America},
       year = {2005}
    }

2004

  • Rau, K.R. and Vogel, A. and Venugopalan, V.: Investigation of laser-induced cell lysis using time-resolved imaging. Appl Phys Lett, no. 84, pp. 2940-2942, 2004
    BibTeX
    @article{Rau,
       author = {Rau, K.R. and Vogel, A. and Venugopalan, V.},
       title = {Investigation of laser-induced cell lysis using time-resolved imaging},
       journal = {Appl Phys Lett},
       volume = {84},
       number = {15},
       pages = {2940-2942},
       year = {2004}
    }
    

2003

  • Vogel, A. and Venugopalan, V.: Mechanisms of Pulsed Laser Ablation of Biological Tissues. Chem. Rev., no. 103, pp. 577-644, 2003
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Venugopalan, V.},
       title = {Mechanisms of Pulsed Laser Ablation of Biological Tissues},
       journal = {Chem. Rev.},
       volume = {103},
       pages = {577-644},
       year = {2003}
    }
    
  • Vogel, Alfred: Mechanism of short-pulsed plasma-mediated laser ablation and disruption. in Lasers in Ophthalmology - Basic, Diagnostic and Surgical Aspects, pp. pp. 99-113, Kugler Publications, The Hague, The Netherlands, 2003
    BibTeX
    @inbook{Vogel,
       author = {Vogel, Alfred},
       title = {Mechanism of short-pulsed plasma-mediated laser ablation and disruption},
       booktitle = {Lasers in Ophthalmology - Basic, Diagnostic and Surgical Aspects},
       editor = {Frankenhauser, F. and Kwasniewska, S.},
       publisher = {Kugler Publications, The Hague, The Netherlands},
       pages = {pp. 99-113},
       year = {2003}
    }
    
  • Vogel, A. and Venugopalan, V.: Additions and Corrections. Chemical Reviews, no. 103, pp. 2079, 2003
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Venugopalan, V.},
       title = {Additions and Corrections},
       journal = {Chemical Reviews},
       volume = {103},
       number = {5},
       pages = {2079},
       year = {2003}
    }
    

2002

  • Brujan, EA. and Keen, G.S. and Vogel, A. and Blake, J.R.: The final stage of the collapse of a cavitation bubble close to a rigid boundary. Phys Fluids, no. 14, pp. 85-92, 2002
    BibTeX
    @article{Brujan2002,
       author = {Brujan, EA. and Keen, G.S. and Vogel, A. and Blake, J.R.},
       title = {The final stage of the collapse of a cavitation bubble close to a rigid boundary},
       journal = {Phys Fluids},
       volume = {14},
       pages = {85-92},
       year = {2002}
    }
    
    
  • Venugopalan, V. and Guerra, A. and Nahen, K. and Vogel, A.: Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation. Phys Rev Let, no. 88, pp. 078103 (1-4), 2002
    BibTeX
    @article{Venogupalan,
       author = {Venugopalan, V. and Guerra, A. and Nahen, K. and Vogel, A.},
       title = {Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation},
       journal = {Phys Rev Let},
       volume = {88},
       number = {7},
       pages = {078103 (1-4)},
       year = {2002}
    }
    
  • Nahen, K. and Vogel, A.: Plume dynamics and shielding by the ablation plume during Er:YAG laser ablation. Journal of Biomedical Optics, no. 7, pp. 165-178, 2002
    BibTeX
    @article{Nahen,
       author = {Nahen, K. and Vogel, A.},
       title = {Plume dynamics and shielding by the ablation plume during Er:YAG laser ablation},
       journal = {Journal of Biomedical Optics},
       volume = {7},
       number = {2},
       pages = {165-178},
       year = {2002}
    }
    
  • Brix, A and Vogel, A and Winkler, J and Dröge, G and Birngruber, R and Laqua, H and Hoerauf, H: Photoablation innerer Netzhautschichten mit dem Erbium: YAG-Laser in vitro. Focus Mul / Medizinische Universität <Lübeck>, no. 19, pp. 35, 2002
    BibTeX Link
    @article{Brix2002,
       author = {Brix, A and Vogel, A and Winkler, J and Dröge, G and Birngruber, R and Laqua, H and Hoerauf, H},
       title = {Photoablation innerer Netzhautschichten mit dem Erbium: YAG-Laser in vitro},
       journal = {Focus Mul / Medizinische Universität <Lübeck>},
       volume = {19},
       number = {1},
       pages = {35},
       ISSN = {0940-9998},
       url = {http://www.zbmed.de/ccmedimages/2002/24278.pdf},
       year = {2002},
       type = {Journal Article}
    }
    
  • Vogel, A. and Schmidt, P. and Flucke, B.: Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses. SPIE Proc. Laser Tissue Interaction XIII, no. 4617A, 2002
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Schmidt, P. and Flucke, B.},
       title = {Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses},
       journal = {SPIE Proc. Laser Tissue Interaction XIII},
       volume = {4617A},
       year = {2002}
    }
    
  • Vogel, A. and Schmidt, P. and Flucke, B.: Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses. SPIE Proc. Laser Tissue Interaction XIII, no. 4617A, 2002
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Schmidt, P. and Flucke, B.},
       title = {Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses},
       journal = {SPIE Proc. Laser Tissue Interaction XIII},
       volume = {4617A},
       year = {2002}
    }
    
  • Vogel, A. and Hüttmann, G. and Paltauf, G.: Low-density plasmas below the optical breakdown threshold: potential hazard for multiphoton microscopy, and a tool for the manipulation of intracellular events. Proc SPIE Multiphoton Microscopy in the Biomedical Sciences II, no. 4620, pp. 202-216, 2002
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Hüttmann, G. and Paltauf, G.},
       title = {Low-density plasmas below the optical breakdown threshold: potential hazard for multiphoton microscopy, and a tool for the manipulation of intracellular events},
       journal = {Proc SPIE "Multiphoton Microscopy in the Biomedical Sciences II"},
       volume = {4620},
       pages = {202-216},
       year = {2002}
    }
    
  • Vogel, Alfred . and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.: Intraocular Nd: YAG Laser Surgery: Light-Tissue Interaction, Damage Range, and Reduction of Collateral Effects. IEEE J Quant Electr, no. 26, pp. 2241-2260, 2002
    BibTeX
    @article{Vogel2002,
       author = {Vogel, Alfred . and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.},
       title = {Intraocular Nd: YAG Laser Surgery: Light-Tissue Interaction, Damage Range, and Reduction of Collateral Effects},
       journal = {IEEE J Quant Electr},
       volume = {26},
       pages = {2241-2260},
       year = {2002},
       type = {Journal Article}
    }
    
  • Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.: Femtosecond-laser-produced low-density plasmas in transparent biological media: A tool for the creation of chemical, thermal and thermomechanical effets below the optical brekdown threshold. Proc. SPIE Commercial and Biological Applications of Ultrafast Lasers IV, no. 4633, pp. 23-37, 2002
    BibTeX
    @article{Vogel, 
       author = {Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.},
       title = {Femtosecond-laser-produced low-density plasmas in transparent biological media: A tool for the creation of chemical, thermal and thermomechanical effets below the optical brekdown threshold},
       journal = {Proc. SPIE "Commercial and Biological Applications of Ultrafast Lasers IV"},
       volume = {4633},
       pages = {23-37},
       year = {2002}
    }
    

2001

  • Nahen, K. and Vogel, Alfred: Shielding by the ablation plume during Er:YAG laser ablation. SPIE Proc., no. 4257, pp. 303-311, 2001
    BibTeX
    @article{Nahen2001,
       author = {Nahen, K. and Vogel, Alfred},
       title = {Shielding by the ablation plume during Er:YAG laser ablation},
       journal = {SPIE Proc.},
       volume = {4257},
       pages = {303-311},
       year = {2001},
       type = {Journal Article}
    }
    
  • Vogel, A. and Noack, J.: Numerical simulation of optical breakdown for cellular surgery at nanosecond to femtosecond time scales. Laser- Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy. SPIE, no. 4433, pp. 70-80, 2001
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Noack, J.},
       title = {Numerical simulation of optical breakdown for cellular surgery at nanosecond to femtosecond time scales},
       journal = {Laser- Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy. SPIE},
       volume = {4433},
       pages = {70-80},
       year = {2001}
    }
    
  • Vogel, A. and Schmidt, P. and Flucke, B.: Minimization of thermomechanical side effects in IR ablation by use of Q-switched double pulses. Laser-Tissue Interaction XII. SPIE, no. 4257, pp. 184-191, 2001
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Schmidt, P. and Flucke, B.},
       title = {Minimization of thermomechanical side effects in IR ablation by use of Q-switched double pulses},
       journal = {Laser-Tissue Interaction XII. SPIE},
       volume = {4257},
       pages = {184-191},
       year = {2001}
    }
    
  • Brujan, EA. and Nahen, K. and Schmidt, P. and Vogel, A.: Dynamics of laser-induced cavitation bubbles near elastic boundary. J Fluid Mech, no. 433, pp. 251-281, 2001
    BibTeX
    @article{Brujan2001,
       author = {Brujan, EA. and Nahen, K. and Schmidt, P. and Vogel, A.},
       title = {Dynamics of laser-induced cavitation bubbles near elastic boundary},
       journal = {J Fluid Mech},
       volume = {433},
       pages = {251-281},
       year = {2001}
    }
    
  • Brujan, Emil-Alexandru and Nahen, Kester and Schmidt, Peter and Vogel, Alfred: Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus. Journal of Fluid Mechanics, no. 433, pp. 283-314, 2001
    BibTeX
    @article{Brujan2001,
       author = {Brujan, Emil-Alexandru and Nahen, Kester and Schmidt, Peter and Vogel, Alfred},
       title = {Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus},
       journal = {Journal of Fluid Mechanics},
       volume = {433},
       pages = {283-314},
       ISSN = {1469-7645},
       year = {2001},
       type = {Journal Article}
    }
    

2000

  • Nahen, Kester and Eisenbeiß, Werner and Vogel, Alfred: Akustische Online-Kontrolle der Er: YAG Laserablation verbrannter Haut. Biomedizinische Technik/Biomedical Engineering, no. 45, pp. 300-301, 2000
    BibTeX
    @article{Nahen2000,
       author = {Nahen, Kester and Eisenbeiß, Werner and Vogel, Alfred},
       title = {Akustische Online-Kontrolle der Er: YAG Laserablation verbrannter Haut},
       journal = {Biomedizinische Technik/Biomedical Engineering},
       volume = {45},
       number = {s1},
       pages = {300-301},
       ISSN = {1862-278X},
       year = {2000},
       type = {Journal Article}
    }
    

1999

  • Noack, J. and Vogel, A.: Laser-induced plasma formation in water at nanosecond to femtosecond time scales: calculation of thresholds, absorption coefficients, and energy density. Quantum Electronics, IEEE Journal of, no. 35, pp. 1156-1167, 1999
    BibTeX
    @article{Noack,
       author = {Noack, J. and Vogel, A.},
       title = {Laser-induced plasma formation in water at nanosecond to femtosecond time scales: calculation of thresholds, absorption coefficients, and energy density},
       journal = {Quantum Electronics, IEEE Journal of},
       volume = {35},
       number = {8},
       pages = {1156-1167},
       keywords = {absorption coefficients
    electron density
    high-speed optical techniques
    multiphoton processes
    photoionisation
    plasma density
    plasma production by laser
    plasma theory
    water
    H<sub>2</sub>O
    absorption coefficient
    breakdown threshold
    cascade ionization
    collision losses
    complex pulse duration dependence
    decreasing laser pulse duration
    distilled water
    energy density
    energy threshold
    femtosecond time scales
    free electron density
    free electrons
    high-power laser pulses
    laser pulse
    laser-induced plasma formation
    multiphoton ionization
    multiphoton ionization gains
    nanosecond laser pulses
    nanosecond time scales
    numerical solution
    plasma absorption coefficient
    plasma energy density
    plasma generation
    plasma transmission
    pulse durations
    quantitative agreement
    rate equation
    recombination losses
    thresholds},
       year = {1999}
    }
    
  • Nahen, K. and Vogel, A.: Investigations on Acoustic On- Line Monitoring of IR Laser Ablation of burned Skin. Laser in Surgery and Medicine, no. 25, pp. 69-78, 1999
    BibTeX
    @article{Nahen,
       author = {Nahen, K. and Vogel, A.},
       title = {Investigations on Acoustic On- Line Monitoring of IR Laser Ablation of burned Skin},
       journal = {Laser in Surgery and Medicine},
       volume = {25},
       pages = {69-78},
       year = {1999}
    }
    
  • Vogel, A. and Nahen, K. and Theisen-Kunde, D. and Birngruber, R. and Thomas, J. and Rockwell, B.A.: Influence of optical aberrations on laser-induced plasma formation in water, and their consequences for intraocular photodisruption. Appl Optics, no. 38, pp. 3636-3643, 1999
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Nahen, K. and Theisen-Kunde, D. and Birngruber, R. and Thomas, J. and Rockwell, B.A.},
       title = {Influence of optical aberrations on laser-induced plasma formation in water, and their consequences for intraocular photodisruption},
       journal = {Appl Optics},
       volume = {38},
       number = {16},
       pages = {3636-3643},
       year = {1999}
    }
    
  • Vogel, A. and Noack, J. and Nahen, K. and Theisen, D. and Busch, S. and Parlitz, U. and Hammer, D.X. and Noojin, G. D. and Rockwell, B.A. and Birngruber, R.: Energy balance of optical breakdown in water at nanosecond to femtosecond time scales. Appl Phys B, no. 68, 1999
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Noack, J. and Nahen, K. and Theisen, D. and Busch, S. and Parlitz, U. and Hammer, D.X. and Noojin, G. D. and Rockwell, B.A. and Birngruber, R.},
       title = {Energy balance of optical breakdown in water at nanosecond to femtosecond time scales},
       journal = {Appl Phys B},
       volume = {68},
       number = {271-280},
       year = {1999}
    }
    

1998

  • Noack, J. and Vogel, A.: Single-shot spatially resolved characterization of laser-induced shock waves in water. Appl Optics, no. 37, pp. 4092-4099, 1998
    BibTeX
    @article{Noack,
       author = {Noack, J. and Vogel, A.},
       title = {Single-shot spatially resolved characterization of laser-induced shock waves in water},
       journal = {Appl Optics},
       volume = {37},
       number = {19},
       pages = {4092-4099},
       year = {1998}
    }
    
  • Scammon, R.J. and Chapyak, E.J. and Godwin, R.P. and Vogel, A.: Simulations of shock waces and cavitation bubbles produced in water by picosecond and nanosecond laser pulses. SPIE Proc., no. 3254, pp. 264-275, 1998
    BibTeX
    @article{Scammon,
       author = {Scammon, R.J. and Chapyak, E.J. and Godwin, R.P. and Vogel, A.},
       title = {Simulations of shock waces and cavitation bubbles produced in water by picosecond and nanosecond laser pulses},
       journal = {SPIE Proc.},
       volume = {3254},
       pages = {264-275},
       year = {1998}
    }
    
  • Geerling, G. and Roider, J. and Schmidt-Erfurth, U. and Nahen, K. and El Hifnawi, E. S. and Laqua, H. and Vogel, A.: Initial clinical experience with the picosecond Nd: YLF laser for intraocular therapeutic applications. Br J Ohthalmol, no. 82, pp. 504-509, 1998
    BibTeX
    @article{Geerling,
       author = {Geerling, G. and Roider, J. and Schmidt-Erfurth, U. and Nahen, K. and El Hifnawi, E. S. and Laqua, H. and Vogel, A.},
       title = {Initial clinical experience with the picosecond Nd: YLF laser for intraocular therapeutic applications},
       journal = {Br J Ohthalmol},
       volume = {82},
       number = {5},
       pages = {504-509},
       year = {1998}
    }
    
  • Noack, J. and Hammer, D.X. and Rockwell, B.A. and Vogel, A. and Noojin, G. D.: Influence of pulse duration on mechanical effects after laser-induced breakdown in water. J Appl Phys, no. 83, pp. 7488-7495, 1998
    BibTeX
    @article{Noack,
       author = {Noack, J. and Hammer, D.X. and Rockwell, B.A. and Vogel, A. and Noojin, G. D.},
       title = {Influence of pulse duration on mechanical effects after laser-induced breakdown in water},
       journal = {J Appl Phys},
       volume = {83},
       number = {12},
       pages = {7488-7495},
       year = {1998}
    }
    

1997

  • Vogel, Alfred and Günther, Thomas and Birngruber, Reginald and Asyo-Vogel, M: Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser. Der Ophthalmologe, no. 94, pp. 467-474, 1997
    BibTeX Link
    @article{Vogel 1997,
       author = {Vogel, Alfred and Günther, Thomas and Birngruber, Reginald and Asyo-Vogel, M},
       title = {Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser},
       journal = {Der Ophthalmologe},
       volume = {94},
       number = {7},
       pages = {467-474},
       keywords = {Schlüsselwörter Refraktive Hornhautchirurgie
    Intrastromale photorefraktive Keratektomie
    Pikosekundenlaser
    Photodisruption
    Kavitation
    Key words Refractive surgery
    Intrastromal photorefractive keratectomy
    Picosecond laser
    Cavitation},
       ISSN = {0941-293X},
       DOI = {10.1007/s003470050141},
       url = {http://dx.doi.org/10.1007/s003470050141},
       year = {1997},
       type = {Journal Article}
    }
    
  • Vogel, Alfred and Günther, Thomas and Birngruber, Reginald and Asyo-Vogel, M: Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser. Der Ophthalmologe, no. 94, pp. 467-474, 1997
    BibTeX Link
    @article{Vogel1997,
       author = {Vogel, Alfred and Günther, Thomas and Birngruber, Reginald and Asyo-Vogel, M},
       title = {Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser},
       journal = {Der Ophthalmologe},
       volume = {94},
       number = {7},
       pages = {467-474},
       keywords = {Schlüsselwörter Refraktive Hornhautchirurgie
    Intrastromale photorefraktive Keratektomie
    Pikosekundenlaser
    Photodisruption
    Kavitation
    Key words Refractive surgery
    Intrastromal photorefractive keratectomy
    Picosecond laser
    Cavitation},
       ISSN = {0941-293X},
       DOI = {10.1007/s003470050141},
       url = {http://dx.doi.org/10.1007/s003470050141},
       year = {1997},
       type = {Journal Article}
    }
    
  • Hammer, D.X. and Jansen, E.D. and Frenz, M. and Nojin, G.D. and Thomas, R.J. and Noack, J. and Vogel, A. and Rockwell, B.A. and Welch, A.J.: Shielding properties of laser-induced breakdown in water from pulse durations from 5 ns to 125 fs.. Appl Optics, no. 36, pp. 5630-5640, 1997
    BibTeX
    @article{Hammer,
       author = {Hammer, D.X. and Jansen, E.D. and Frenz, M. and Nojin, G.D. and Thomas, R.J. and Noack, J. and Vogel, A. and Rockwell, B.A. and Welch, A.J.},
       title = {Shielding properties of laser-induced breakdown in water from pulse durations from 5 ns to 125 fs.},
       journal = {Appl Optics},
       volume = {36},
       pages = {5630-5640},
       year = {1997}
    }
    
  • Vogel, A.: Nonlinear absorption: intraocular microsurgery and laser lithotripsy. Phys. Med. Biol., no. 42, pp. 895, 1997
    BibTeX
    @article{Vogel,
       author = {Vogel, A.},
       title = {Nonlinear absorption: intraocular microsurgery and laser lithotripsy },
       journal = {Phys. Med. Biol.},
       volume = {42},
       number = {5},
       pages = {895},
       year = {1997}
    }
    
  • Vogel, A. and Gunther, T. and Asiyo-Vogel, M. and Birngruber, R.: Investigations on the origin of refractive effects in intrastromal refractive surgery with the picosecond laser. Ophthalmologe, no. 94, pp. 467-474, 1997
    BibTeX Link
    @article{Vogel1997,
       author = {Vogel, A. and Gunther, T. and Asiyo-Vogel, M. and Birngruber, R.},
       title = {Investigations on the origin of refractive effects in intrastromal refractive surgery with the picosecond laser},
       journal = {Ophthalmologe},
       volume = {94},
       number = {7},
       pages = {467-474},
       note = {Yp140
    Times Cited:2
    Cited References Count:21},
       abstract = {Background: Picosecond laser intrastromal photorefractive keratectomy (ISPRK) aims at achieving a flattening of the central cornea by plasma-mediated tissue evaporation without affecting the anterior or posterior corneal layers. We investigated the laser-induced tissue effects to establish a functional relationship between laser parameters and tissue removal and to assess their influence on the healing process and long-term refractive changes.
    Materials and methods: A modified ISL 2001 System with a cone angle of 30 degrees was used for in vitro investigations of the laser effects in water and porcine cornea. Photographic methods were used to determine the plasma volume and the thickness of the laser-generated intrastromal bubble layer as a function of the pulse energy and the number and separation in which the pulses were applied (216 eyes). Histological evaluation was done by polarization microscopy (9 eyes).
    Results: Polarization microscopy revealed only minor signs of thermal tissue damage. The maximum amount of tissue that can be evaporated without damaging the outer corneal layers corresponds to a layer about 10 mu m thick. With a 6-mm optical zone, this tissue removal yields an immediate refractive effect of only 0.85 dpt. Stronger long-term refractive changes observed in animal experiments and clinical studies must thus be due to the healing response of the cornea. The healing response may be induced by mechanical distortion due to intrastromal bubble formation affecting about one third of the corneal thickness.
    Conclusion: Since the refractive effects are apparently strongly influenced by corneal healing, they are poorly predictable and can probably not be used for clinical purposes.},
       keywords = {refractive surgery
    intrastromal photorefractive keratectomy
    picosecond laser
    photodisruption
    cavitation
    photorefractive keratectomy
    intraocular photodisruption
    corneal tissue
    pulses},
       ISSN = {0941-293X},
       DOI = {DOI 10.1007/s003470050141},
       url = {<Go to ISI>://WOS:000071246700001},
       year = {1997},
       type = {Journal Article}
    }
    
  • Noack, J. and Tonnies, R. and Hohla, K. and Birngruber, R. and Vogel, A.: Influence of ablation plume dynamics on the formation of central islands in excimer laser photorefractive keratectomy. Ophthalmology, no. 104, pp. 823-30, 1997
    BibTeX
    @article{Noack,
       author = {Noack, J. and Tonnies, R. and Hohla, K. and Birngruber, R. and Vogel, A.},
       title = {Influence of ablation plume dynamics on the formation of central islands in excimer laser photorefractive keratectomy},
       journal = {Ophthalmology},
       volume = {104},
       number = {5},
       pages = {823-30},
       note = {0161-6420 (Print)
    Comparative Study
    In Vitro
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {PURPOSE: The aim of this study was to understand the dynamics of ablation products during excimer laser photorefractive keratectomy, and their influence on the formation of central islands. METHOD: Laser flash photography was used to investigate the dynamics of ablation products during photorefractive keratectomy. The ablation plume over polymethyl methacrylate (PMMA) and porcine cornea targets ablated with different zone diameters was imaged at various times between 10 musec and 100 msec after the ablating laser pulse. On PMMA targets, the profiles of the resulting ablation craters were measured. RESULTS: In all cases, the ablation products formed a ring vortex. The plume velocities on cornea were found to be approximately twice as fast as on PMMA for all zone diameters. For both materials, the ablation plume evolves faster for smaller zone diameters. Central islands were observed for zone diameters between 1 and 7 mm on PMMA substrates. The islands became more pronounced with increasing zone diameter. CONCLUSIONS: A major cause for the formation of central islands was found to be particle redeposition at the center of the ablation zone. Because of the vortex dynamics, redeposition of particles favorably occurs at the center of the ablation zone. Additionally, the dynamics of the ablation plume lead to a concentration of airborne particles over the center of the ablation zone, which also may contribute to the creation of central islands by partial absorption of the next excimer laser pulse.},
       keywords = {Animals
    Cornea/*pathology/*surgery
    Image Processing, Computer-Assisted
    *Keratectomy, Photorefractive, Excimer Laser
    Methylmethacrylates
    Models, Anatomic
    Swine
    Time and Motion Studies
    Volatilization},
       year = {1997}
    }
    
  • Asiyo-Vogel, M. and Brinkmann, R and Notbohm, H. and Eggers, R. and Lubatschowski, H. and Laqua, H. and Vogel, A.: Histologic analysis of thermal effects of laserthermokeratoplasty and corneal ablation using Sirius-Red polarization microscopy. J Cataract Refr Surg, no. 23, pp. 515-526, 1997
    BibTeX
    @article{Asiyo-Vogel,
       author = {Asiyo-Vogel, M. and Brinkmann, R and Notbohm, H. and Eggers, R. and Lubatschowski, H. and Laqua, H. and Vogel, A.},
       title = {Histologic analysis of thermal effects of laserthermokeratoplasty and corneal ablation using Sirius-Red polarization microscopy},
       journal = {J Cataract Refr Surg},
       volume = {23},
       pages = {515-526},
       year = {1997}
    }
    
  • Vogel, A. and Günther, T. and Asiyo-Vogel, M. and Birngruber, R.: Factors determining the refractive effects of intrastromal photorefractive keratectomy with the picosecond laser. J Cataract Refract Surg, no. 23, pp. 1301-1310, 1997
    BibTeX
    @article{Vogel1997,
       author = {Vogel, A. and Günther, T. and Asiyo-Vogel, M. and Birngruber, R.},
       title = {Factors determining the refractive effects of intrastromal photorefractive keratectomy with the picosecond laser},
       journal = {J Cataract Refract Surg},
       volume = {23},
       number = {9},
       pages = {1301-1310},
       abstract = {To determine the relationship between laser parameters and tissue removal with picosecond laser intrastromal photorefractive keratectomy (ISPRK) and to assess the effect of the parameters on the healing process and the long-term refractive changes.},
       keywords = {Animals
    Corneal Stroma
    Follow-Up Studies
    Lasers, Excimer
    Microscopy, Polarization
    Photorefractive Keratectomy
    Refraction, Ocular
    Refractive Errors
    Swine
    Wound Healing
    pathology
    physiopathology
    surgery
    adverse effects
    methods
    physiology
    etiology},
       year = {1997}
    }
    
  • Asiyo-Vogel, M. N. and Koop, N. and Brinkmann, R. and Engelhardt, R. and Eggers, R. and Birngruber, R. and Vogel, A.: Evaluation of LTK lesions by optical low coherence tomography (OCT) and polarization microscopy after Sirius-Red staining. Ophthalmologe, no. 94, pp. 487-491, 1997
    BibTeX Link
    @article{Asiyo-Vogel1997,
       author = {Asiyo-Vogel, M. N. and Koop, N. and Brinkmann, R. and Engelhardt, R. and Eggers, R. and Birngruber, R. and Vogel, A.},
       title = {Evaluation of LTK lesions by optical low coherence tomography (OCT) and polarization microscopy after Sirius-Red staining},
       journal = {Ophthalmologe},
       volume = {94},
       number = {7},
       pages = {487-491},
       note = {Yp140
    Times Cited:5
    Cited References Count:21},
       abstract = {Background: Information on the extent and degree of the thermal effect produced is of great importance for control of the laser dosage in laser thermokeratoplasty (LTK) and for postoperative follow-up. We investigated on acute LTK effects which information images obtained by optical low coherence tomography (OCT) offer compared to those obtained by polarization microscopy.
    Methods: Porcine eyes were irradiated through a 400 mu m quartz fiber using light from a laser diode emitting up to 300 mW at a wavelength of 1.86 mu m. Thermal lesions of varying strength were scanned using an experimental OCT device with about 25 mu m lateral and 20 mu m axial resolution. Histologic evaluation of the scanned areas was done by polarization microscopy after Sirius-Red staining, and similar lesions were also analyzed by TEM.
    Results: Both methods differentiated three damage zones: a transition zone, a zone of moderate coagulation, and a central zone of strong coagulation. In the transition zone,increased birefringence was seen in polarization microscopy, which correlated with increased light scattering seen in the DCT images,ln the moderately coagulated zone, a decrease in birefringence was associated with an even stronger increase of the OCT signal, In the central zone,a loss of the fibrillar tissue structure was observed, which led to a complete loss of birefringence and a strong reduction of the OCT signal.
    Conclusions: Although OCT does not provide the detailed information on thermal changes of tissue seen by the histologic method, it offers information on the extent and degree of tissue changes without preparation artifacts and provides a non-invasive method of immediate and follow-up control of LTK lesions, A quantitative analysis of changes in corneal thickness and curvature is much simpler than by a slit lamp. Time-resolved measurements of corneal light scattering may be used for on-line control of the laser-light dosage during LTK.},
       keywords = {refractive surgery
    laser thermokeratoplasty
    collagen denaturation
    collagen shrinkage
    optical low coherence tomography
    polarization microscopy
    sirius-red staining
    tissue
    collagen
    eye},
       ISSN = {0941-293X},
       DOI = {DOI 10.1007/s003470050144},
       url = {<Go to ISI>://WOS:000071246700004},
       year = {1997},
       type = {Journal Article}
    }
    
  • Asiyo-Vogel, M and Koop, N and Brinkmann, R and Engelhardt, R and Eggers, R and Birngruber, R and Vogel, A: Darstellung von LTK-Läsionen durch optische Kurzkohärenztomographie (OCT) und Polarisationsmikroskopie nach Sirius-Rot-Färbung. Ophthalmologe, no. 94, pp. 487-491, 1997
    BibTeX
    @article{Asiyo-Vogel1997,
       author = {Asiyo-Vogel, M and Koop, N and Brinkmann, R and Engelhardt, R and Eggers, R and Birngruber, R and Vogel, A},
       title = {Darstellung von LTK-Läsionen durch optische Kurzkohärenztomographie (OCT) und Polarisationsmikroskopie nach Sirius-Rot-Färbung},
       journal = {Ophthalmologe},
       volume = {94},
       pages = {487-491},
       year = {1997}
    }
    
  • Brinkmann, R. and Koop, N. and Kampmeier, J. and Bruhns, A. and AsiyoVogel, M. and Engelhardt, R. and Birngruber, R.: Corneal collagen denaturation in laser thermokeratoplasty (LTK). Investigative Ophthalmology & Visual Science, no. 38, pp. 2514-2514, 1997
    BibTeX
    @article{Brinkmann1997,
       author = {Brinkmann, R. and Koop, N. and Kampmeier, J. and Bruhns, A. and AsiyoVogel, M. and Engelhardt, R. and Birngruber, R.},
       title = {Corneal collagen denaturation in laser thermokeratoplasty (LTK)},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {38},
       number = {4},
       pages = {2514-2514},
       note = {1
    Wn186
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:A1997WN18602506},
       year = {1997},
       type = {Journal Article}
    }
    
  • Chapyak, J. and Godwin, R.P. and Vogel, A.: A comparison of numerical simulations and laboratory studies on shock waves and cavitation bubble growth produced by optical breakdown in water. SPIE Proc., no. 2975, pp. 335-342, 1997
    BibTeX
    @article{Chapyak,
       author = {Chapyak, J. and Godwin, R.P. and Vogel, A.},
       title = {A comparison of numerical simulations and laboratory studies on shock waves and cavitation bubble growth produced by optical breakdown in water},
       journal = {SPIE Proc.},
       volume = {2975},
       pages = {335-342},
       year = {1997}
    }
    

1996

  • Vogel, A. and Busch, S.: Shock wave emission and cavitation bubble generation by picosecond and nanosecond optical breakdown in water. J Acoust Soc Am, no. 100, pp. 148-165, 1996
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Busch, S.},
       title = {Shock wave emission and cavitation bubble generation by picosecond and nanosecond optical breakdown in water},
       journal = {J Acoust Soc Am},
       volume = {100},
       pages = {148-165},
       year = {1996}
    }
    
  • Nahen, K. and Vogel, A.: Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part II: Transmission, Scattering, and Reflection. IEEE, no. 2, pp. 861-871, 1996
    BibTeX
    @article{Nahen,
       author = {Nahen, K. and Vogel, A.},
       title = {Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part II: Transmission, Scattering, and Reflection},
       journal = {IEEE},
       volume = {2},
       number = {4},
       pages = {861-871},
       year = {1996}
    }
    
  • Vogel, A. and Nahen, K. and Theisen, D and Noack, J.: Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part I: Optical Breakdown at Threshold and Superthreshold Irradiance.. IEEE, no. 2, pp. 847-860, 1996
    BibTeX
    @article{Vogel1996,
       author = {Vogel, A. and Nahen, K. and Theisen, D and Noack, J.},
       title = {Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part I: Optical Breakdown at Threshold and Superthreshold Irradiance.},
       journal = {IEEE},
       volume = {2},
       number = {4},
       pages = {847-860},
       year = {1996}
    }
    
  • Gerling, G. and Vogel, A. and ElHifnawi, E. and Koop, N. and Droge, G. and Birngruber, R. and Brinkmann, R.: Morphological and biomorphometrical observations on laser thermal keratoplasty - Histological and biomorphometrical examination of the relationship between refractive change and the volume of laser thermal keratoplasty lesions following Cr:Tm:Ho:YAG laser treatment. German Journal of Ophthalmology, no. 5, pp. 84-91, 1996
    BibTeX
    @article{Gerling1996,
       author = {Gerling, G. and Vogel, A. and ElHifnawi, E. and Koop, N. and Droge, G. and Birngruber, R. and Brinkmann, R.},
       title = {Morphological and biomorphometrical observations on laser thermal keratoplasty - Histological and biomorphometrical examination of the relationship between refractive change and the volume of laser thermal keratoplasty lesions following Cr:Tm:Ho:YAG laser treatment},
       journal = {German Journal of Ophthalmology},
       volume = {5},
       number = {2},
       pages = {84-91},
       note = {Vf915
    Times Cited:4
    Cited References Count:21},
       abstract = {Laser thermal keratoplasty (LTK) is currently under clinical trial for the correction of hyperopia and hyperopic astigmatism by means of collagen coagulation in the peripheral cornea. The purpose of our study was to optimize the ratio between the volume of damaged corneal stroma and the refractive effect so as to minimize potential side effects such as endothelial damage or induction of glare phenomena. We therefore performed histological and morphometrical examinations of enucleated pig eyes to determine the relationship between the coagulated stromal volume and the refractive change after LTK using a pulsed Cr: Tm: Ho: YAG laser (wavelength 2.12 mu m) on enucleated pig eyes. The refractive change was documented with a Littman ophthalmometer. Morphometrical analysis was performed using polarized light microscopy of sirius red-stained specimens. This special stain separated the thermally changed stroma into a dark, nonbirefringent center and a birefringent peripheral zone. The volume of both zones was positively correlated with the refractive change induced. The volume was in turn influenced by the choice of laser parameters, From the ratio of the volume to the refractive change it was found that pulse energies above 30 mJ led to an enlargement of the coagulation volume without increasing the refractive change effectively. The use of high pulse energies did not improve the effect of LTK but only increased the risk of unwanted side effects. However, an increase in the laser repetition rate at a constant pulse number per spot led to refractive changes with a minimal coagulation volume. The highest relative refractive change was achieved with a dark central zone and a birefringent zone, each having a volume of about 50 - 80 x 10(-3) mm(3).},
       keywords = {laser thermal keratoplasty
    hyperopic correction
    biomorphometry
    sirius red stain
    polarization microscopy
    organization
    microscopy
    collagen},
       ISSN = {0941-2921},
       url = {<Go to ISI>://WOS:A1996VF91500004},
       year = {1996},
       type = {Journal Article}
    }
    
  • Vogel, A. and Engelhardt, R. and Behnle, U. and Parlitz, U.: Minimization of cavitation effects in pulsed laser ablation illustrated on laser angioplasty. Appl Phys B, no. 62, pp. 173-182, 1996
    BibTeX
    @article{Vogel1996,
       author = {Vogel, A. and Engelhardt, R. and Behnle, U. and Parlitz, U.},
       title = {Minimization of cavitation effects in pulsed laser ablation illustrated on laser angioplasty},
       journal = {Appl Phys B},
       volume = {62},
       pages = {173-182},
       year = {1996}
    }
    
  • Zwaan, M. and Behnle, U. and Engelhardt, R. and Vogel, A. and Kloess, W. and Birngruber, R. and Weiss, H. D.: In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium.. Fortschr Röntgenstr, no. 164, pp. 68-71, 1996
    BibTeX
    @article{Zwaan,
       author = {Zwaan, M. and Behnle, U. and Engelhardt, R. and Vogel, A. and Kloess, W. and Birngruber, R. and Weiss, H. D.},
       title = {In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium.},
       journal = {Fortschr Röntgenstr},
       volume = {164},
       number = {1},
       pages = {68-71},
       year = {1996}
    }
    
  • Brinkmann, R. and Koop, N. and AsiyoVogel, M. N. and Kaftan, B. and Birngruber, R. and Engelhardt, R.: CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy. Investigative Ophthalmology & Visual Science, no. 37, pp. 305-305, 1996
    BibTeX
    @article{Brinkmann1996,
       author = {Brinkmann, R. and Koop, N. and AsiyoVogel, M. N. and Kaftan, B. and Birngruber, R. and Engelhardt, R.},
       title = {CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {37},
       number = {3},
       pages = {305-305},
       note = {Tx397
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:A1996TX39700305},
       year = {1996},
       type = {Journal Article}
    }
    

1994

  • VOGEL, A. and ASIYO-VOGEL, M. and BIRNGRUBER, R.: Untersuchungen zur intrastromalen refraktiven Hornhautchirurgie mit Picosekunden-Nd: YAG-Laser-Pulsen. no. 91, Springer, Berlin, ALLEMAGNE, 1994
    BibTeX
    @book{Vogel,
       author = {VOGEL, A. and ASIYO-VOGEL, M. and BIRNGRUBER, R.},
       title = {Untersuchungen zur intrastromalen refraktiven Hornhautchirurgie mit Picosekunden-Nd: YAG-Laser-Pulsen},
       publisher = {Springer},
       address = {Berlin, ALLEMAGNE},
       volume = {91},
       keywords = {Surgery
    Chirurgie
    Cornea
    Corn&#233
    e
    YAG laser
    Laser YAG
    Neodymium
    N&#233
    odyme
    Stroma
    Laser produced plasma
    Plasma produit par laser
    Cavitation bubble
    Bulle cavitation
    Eye
    Oeil
    Sheep
    Mouton
    Animal
    In vitro
    Artiodactyla
    Ungulata
    Mammalia
    Vertebrata},
       year = {1994}
    }
    
  • Ludwig, K. and Busch, L. C. and Jungnickel, K. and Vogel, A.: Präparation critical-point-getrockneter Mausembryonen mit einem Laserskalpell. Ann Anat, no. 176, pp. 559 - 563, 1994
    BibTeX
    @article{Ludwig,
       author = {Ludwig, K. and Busch, L. C. and Jungnickel, K. and Vogel, A.},
       title = {Präparation critical-point-getrockneter Mausembryonen mit einem Laserskalpell},
       journal = {Ann Anat},
       volume = {176},
       pages = {559 - 563},
       year = {1994}
    }
    
  • Vogel, A. and Busch, S. and Jungnickel, K. and Birngruber, R.: Mechanisms of intraocular photodisruption with picosecond and nanosecond laser pulses. Lasers Surg Med, no. 15, pp. 32-43, 1994
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Busch, S. and Jungnickel, K. and Birngruber, R.},
       title = {Mechanisms of intraocular photodisruption with picosecond and nanosecond laser pulses},
       journal = {Lasers Surg Med},
       volume = {15},
       number = {1},
       pages = {32-43},
       note = {0196-8092 (Print)
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {Nd:YAG laser photodisruption with nanosecond (ns) pulses is an established method for intraocular surgery. In order to assess whether an increased precision can be achieved by the use of picosecond (ps) pulses, the plasma size, the shock wave characteristics, and the cavitation bubble expansion after optical breakdown with ps- and ns-laser pulses were investigated by time-resolved photography and acoustic measurements. Nd:YAG laser pulses with a duration of 30 ps and 6 ns, respectively, were focused into a water-filled glass cuvette. Frequency doubled light from the same laser pulses was optically delayed between 2 ns and 136 ns and used as illumination light source for photography. Since the individual events were well reproducible, the shock wave and bubble wall position could be determined as a function of time. From the slope of these r(t) curves, the shock wave and bubble wall velocities were determined, and the shock wave pressure was calculated from the shock velocity. The plasma size at various laser pulse energies was measured from photographs of the plasma radiation. The breakdown thresholds at 30 ps and 6 ns pulse duration were found to be 15 microJ and 200 microJ, respectively. At threshold, ps-plasmas are shorter than ns-plasmas, but at the same pulse energy they are always approximately 2.5 times longer. The initial shock pressures were 17 kbar after ps-pulses with an energy of 50 microJ, and 21 kbar after 1 mJ ns-pulses. The pressure amplitude decayed much faster after the ps-pulses. The maximum expansion velocity of the cavitation bubble was 350 m/s after a 50 microJ ps-pulse, but 1,600 m/s after a 1 mJ ns-pulse. The side effects of intraocular microsurgery associated with shock wave emission and cavitation bubble expansion can be considerably reduced by the use of ps-pulses, and new applications of photodisruption may become possible.},
       keywords = {Eye/*radiation effects
    Humans
    *Laser Surgery/methods
    Models, Structural
    Physics},
       year = {1994}
    }
    
  • Hettlich, H. J. and Lucke, K. and Asiyo-Vogel, M. N. and Schulte, M. and Vogel, Alfred: Lens refilling and endocapsular polymerization of an injectable intraocular lens: in vitro and in vivo study of potential risks and benefits. J Cataract Refract Surg, no. 20, pp. 115-23, 1994
    BibTeX
    @article{Hettlich1994,
       author = {Hettlich, H. J. and Lucke, K. and Asiyo-Vogel, M. N. and Schulte, M. and Vogel, Alfred},
       title = {Lens refilling and endocapsular polymerization of an injectable intraocular lens: in vitro and in vivo study of potential risks and benefits},
       journal = {J Cataract Refract Surg},
       volume = {20},
       number = {2},
       pages = {115-23},
       note = {Using Smart Source Parsing
    Mar},
       abstract = {Endocapsular cataract removal and injection of a liquid artificial lens has several advantages, including restitution of accommodation, small corneoscleral incision, a more physiological position of the intraocular lens, and a reduced rate of secondary opacification. Our technique consists of bimanual phacofragmentation followed by injection of a fluid monomeric material that can be polymerized inside the capsular bag by short light exposure. Our study assessed the potential risks of the technique (e.g., heat damage to ocular tissue, light damage to the retina) and investigated the technique in vivo. We performed in vitro experiments on porcine cadaver eyes and an in vivo study on 15 rabbits. After a clinical follow-up of at least 12 weeks, the eyes were investigated histopathologically. During the polymerization process, the highest temperature measured at the posterior lens capsule was 45.1 degrees Celsius for a few seconds. The measured irradiance (0.065 watts per cm2) and the risk of photochemical damage to the retina during 20 seconds of polymerization were comparable to that caused by 1.5 minutes of standard coaxial illumination with the operating microscope. In vivo there were no serious inflammatory reactions except in four cases in which there had been intraoperative problems. The rate of secondary opacification appeared less than in conventional intraocular lens implantation in rabbits, especially when the capsule refilled completely. Retinal damage could not be detected histopathologically. In conclusion, refilling techniques may be successful once appropriate refilling materials become available.},
       ISSN = {0886-3350 (Print)
    0886-3350 (Linking)},
       year = {1994},
       type = {Journal Article}
    }
    
  • Vogel, A. and Asiyovogel, M. and Birngruber, R.: Investigations on Intrastromal Refractive Surgery with Picosecond Nd-Yag Laser-Pulses. Investigative Ophthalmology & Visual Science, no. 35, pp. 2155-2155, 1994
    BibTeX Link
    @article{Vogel1994,
       author = {Vogel, A. and Asiyovogel, M. and Birngruber, R.},
       title = {Investigations on Intrastromal Refractive Surgery with Picosecond Nd-Yag Laser-Pulses},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {35},
       number = {4},
       pages = {2155-2155},
       note = {Mz585
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:A1994MZ58504161},
       year = {1994},
       type = {Journal Article}
    }
    
  • Vogel, A. and Capon, M. R. and Asiyo-Vogel, M. N. and Birngruber, R.: Intraocular photodisruption with picosecond and nanosecond laser pulses: tissue effects in cornea, lens, and retina. Invest Ophthalmol Vis Sci, no. 35, pp. 3032-44, 1994
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Capon, M. R. and Asiyo-Vogel, M. and Birngruber, R.},
       title = {Intraocular photodisruption with picosecond and nanosecond laser pulses: tissue effects in cornea, lens, and retina},
       journal = {Invest Ophthalmol Vis Sci},
       volume = {35},
       number = {7},
       pages = {3032-44},
       note = {0146-0404 (Print)
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {PURPOSE. Nd:YAG laser photodisruption with nanosecond (ns) pulses in the millijoule range is an established tool for intraocular surgery. This study investigates tissue effects in cornea, lens, and retina to assess whether picosecond (ps) pulses with energies in the microjoule range can increase the surgical precision, reduce collateral damage, and allow applications requiring more localized tissue effects than can be achieved with ns pulses. METHODS. Both ps and ns Nd:YAG laser effects on Descemet's membrane, in the corneal stroma, in the lens, and at the retina were investigated in vitro in bovine and sheep eyes and in cataractous human lens nuclei. For each tissue, the optical breakdown threshold was determined. The morphology of the tissue effects and the damage range of the laser pulses were examined by light and scanning electron microscopy. The cavitation bubble dynamics during the formation of corneal intrastromal laser effects were documented by time-resolved photography. RESULTS. The optical breakdown threshold for ps pulses in clear cornea, lens, and vitreous is, on average, 12 times lower than that for ns pulses. In cataractous lens nuclei, it is lower by a factor of 7. Using ps pulses, Descemet's membrane could be dissected with fewer disruptive side effects than with ns pulses, whereby the damage range decreased by a factor of 3. The range for retinal damage was only 0.5 mm when 200 microJ ps pulses were focused into the vitreous. Picosecond pulses could be used for corneal intrastromal tissue evaporation without damaging the corneal epithelium or endothelium, when the pulses were applied in the anterior part of the stroma. The range for endothelial damage was 150 microns at 80 microJ pulse energy. Intrastromal corneal refractive surgery is compromised by the laser-induced cavitation effects. Tissue displacement during bubble expansion is more pronounced than tissue evaporation, and irregular bubble formation creates difficulties in producing predictable refractive changes. CONCLUSIONS. The use of ps pulses improves the precision of intraocular Nd:YAG laser surgery and diminishes unwanted disruptive side effects, thereby widening the field of potential applications. Promising fields for further studies are intrastromal corneal refractive surgery, cataract fragmentation, membrane cutting, and vitreolysis close to the retina.},
       keywords = {Animals
    Cattle
    Cornea/injuries/surgery/*ultrastructure
    Laser Surgery/adverse effects/instrumentation/*methods
    Lens, Crystalline/injuries/surgery/*ultrastructure
    Microscopy, Electron, Scanning
    Retina/injuries/surgery/*ultrastructure
    Sheep},
       year = {1994}
    }
    
  • Jungnickel, Kerstin and Vogel, Alfred: Interaction of two laser-induced cavitation bubbles. in Bubble Dynamics and Interface Phenomena, no. 23, pp. 47-53, Springer Netherlands, 1994
    BibTeX Link
    @inbook{Jungnickel1994,
       author = {Jungnickel, Kerstin and Vogel, Alfred},
       title = {Interaction of two laser-induced cavitation bubbles},
       booktitle = {Bubble Dynamics and Interface Phenomena},
       editor = {Blake, J. R. and Boulton-Stone, J. M. and Thomas, N. H.},
       series = {Fluid Mechanics and Its Applications},
       publisher = {Springer Netherlands},
       volume = {23},
       chapter = {4},
       pages = {47-53},
       ISBN = {978-94-010-4404-2},
       DOI = {10.1007/978-94-011-0938-3_4},
       url = {http://dx.doi.org/10.1007/978-94-011-0938-3_4},
       year = {1994},
       type = {Book Section}
    }
    
  • Vogel, Alfred and Asiyo-Vogel, M. and Birngruber, R.: [Intrastromal refractive corneal surgery with pico-second Nd:YAG laser pulses]. Ophthalmologe, no. 91, pp. 655-62, 1994
    BibTeX
    @article{Vogel1994,
       author = {Vogel, Alfred and Asiyo-Vogel, M. and Birngruber, R.},
       title = {[Intrastromal refractive corneal surgery with pico-second Nd:YAG laser pulses]},
       journal = {Ophthalmologe},
       volume = {91},
       number = {5},
       pages = {655-62},
       note = {0941-293X (Print)
    English Abstract
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {Intrastromal laser surgery with picosecond pulses aims to achieve refractive changes of the cornea without damaging the epithelium, Bowman's membrane, or the endothelium. For that, a tissue layer with well-defined thickness has to be evaporated by creating laser plasmas within the corneal stroma. We investigated the plasma formation and the plasma-induced shock wave emission and bubble generation (cavitation) in the cornea, as well as the tissue effects and the range for endothelial damage. The laser light source used was an Nd:YAG laser emitting pulses with a duration of 30 ps at a repetition rate of 10 Hz. Intrastromal plasma formation and cavitation were investigated in sheep eyes in vitro by means of time-resolved macro-photography with 20 ns exposure time. Photographs were taken at various delay times (3 microseconds-2 min) after the release of the Nd:YAG laser pulse. The morphology of the laser effects and the incidence of endothelial damage was investigated by light-microscopic inspection of histological cross sections of the irradiated corneas. The minimal plasma size at energies close to the breakdown threshold was about 40 microns. Using a laser effects could be created without causing microscopically detectable damage to the epithelium, endothelium, or Bowman's membrane. To avoid damage, the distance between endothelium and laser focus had to be larger than 150 microns. Shock wave-induced tissue damage was not observed, although the maximum shock wave pressure was up to 13 kbar. The laser-generated intrastromal cavities are at least 10 times larger than the plasma volume.(ABSTRACT TRUNCATED AT 250 WORDS)},
       keywords = {Animals
    Corneal Stroma/pathology/*surgery
    Endothelium, Corneal/pathology
    Epithelium/pathology
    Equipment Design
    Laser Surgery/*instrumentation
    *Refraction, Ocular
    Sheep
    Surface Properties},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7812100},
       year = {1994},
       type = {Journal Article}
    }
    

1993

  • Birngruber, R. and Hefetz, Y. and Roider, J. and Schmidt, U. and Fujimoto, J. G. and Puliafito, C. A. and Vogel, Alfred: [Spatial confinement of intraocular picoseconds-photodisruption effects]. Ophthalmologe, no. 90, pp. 387-90, 1993
    BibTeX
    @article{Birngruber1993,
       author = {Birngruber, R. and Hefetz, Y. and Roider, J. and Schmidt, U. and Fujimoto, J. G. and Puliafito, C. A. and Vogel, Alfred},
       title = {[Spatial confinement of intraocular picoseconds-photodisruption effects]},
       journal = {Ophthalmologe},
       volume = {90},
       number = {4},
       pages = {387-90},
       note = {0941-293X (Print)
    English Abstract
    Journal Article},
       abstract = {Laser photodisruption is a routinely performed clinical procedure in intraocular microsurgery of post-cataract membranes, anterior synechies and iridectomies. Damage ranges of several millimeters in diameter, however, limit the use of nanosecond photodisruption close to delicate structures, e.g., in the posterior vitreous. Multiple ps-laser pulses of about 100 microJ pulse energy were used to produce disruptive effects in the anterior lens capsule in rabbit eyes in vivo. Ophthalmoscopical and morphological investigations of these effects were compared with those of minimal ns-disruptions. The direct tissue separation effects as well as the collateral damage zones are about one order of magnitude smaller if ps-laser pulses are used. Minimal sizes of disruptive effects are about 50 microns to 150 microns and 500 microns to 1000 microns for ps- and ns-pulses, respectively. The substantial improvement of spatial confinement of ps-photodisruption enables increased precision of intraocular laser microsurgery and opens up new areas of clinical application in structures like the cornea, anterior chamber angle, and crystalline lens.},
       keywords = {Animals
    Lasers/*adverse effects
    Lens Capsule, Crystalline/*injuries/pathology
    Light Coagulation/*instrumentation
    Microsurgery/instrumentation
    Rabbits},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8374239},
       year = {1993},
       type = {Journal Article}
    }
    

1992

  • Jungnickel, K and Rein, S and Vogel, A: Untersuchungen zur Plasmabildung bei der Nd: YAG-Laserchirurgie: Katarakt. Der Ophthalmologe, no. 89, pp. 283-287, 1992
    BibTeX
    @article{Jungnickel1992,
       author = {Jungnickel, K and Rein, S and Vogel, A},
       title = {Untersuchungen zur Plasmabildung bei der Nd: YAG-Laserchirurgie: Katarakt},
       journal = {Der Ophthalmologe},
       volume = {89},
       number = {4},
       pages = {283-287},
       ISSN = {0941-293X},
       year = {1992},
       type = {Journal Article}
    }
    
  • Schmidt-Erfurth, U. and Vogel, A. and Birngruber, R.: The influence of wavelength on the laser power required for retinal photocoagulation in cataractous human eyes.. Lasers Light Ophthalmol, no. 5, pp. 69-78, 1992
    BibTeX
    @article{Schmidt,
       author = {Schmidt-Erfurth, U. and Vogel, A. and Birngruber, R.},
       title = {The influence of wavelength on the laser power required for retinal photocoagulation in cataractous human eyes.},
       journal = {Lasers Light Ophthalmol},
       volume = {5},
       number = {2},
       pages = {69-78},
       year = {1992}
    }
    
  • Vogel, A. and Birngruber, R.: Temperature profiles in human retina and choroid during laser coagulation with different wavelengths ranging from 514 to 810 nm.. Lasers Light Ophthalmol, no. 5, pp. 9-16, 1992
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Birngruber, R.},
       title = {Temperature profiles in human retina and choroid during laser coagulation with different wavelengths ranging from 514 to 810 nm.},
       journal = {Lasers Light Ophthalmol},
       volume = {5},
       number = {1},
       pages = {9-16},
       year = {1992}
    }
    
  • Gabel, V. P. and Lorenz, B. and Obana, A. and Vogel, Alfred and Birngruber, R.: Problems of clinical application of diode lasers.. Lasers Light Ophthalmol, no. 4, pp. 157-163, 1992
    BibTeX
    @article{Abel1992,
       author = {Gabel, V. P. and Lorenz, B. and Obana, A. and Vogel, Alfred and Birngruber, R.},
       title = {Problems of clinical application of diode lasers.},
       journal = {Lasers Light Ophthalmol},
       volume = {4},
       number = {3/4},
       pages = {157-163},
       year = {1992},
       type = {Journal Article}
    }
    
  • Jungnickel, K. and Vogel, A.: Efficiency of bursts in intraocular Nd: YAG laser surgery. Lasers and Light in Ophthalmology, no. 5, pp. 95 - 99, 1992
    BibTeX
    @article{Jungnickel1992,
       author = {Jungnickel, K. and Vogel, A.},
       title = {Efficiency of bursts in intraocular Nd: YAG laser surgery},
       journal = {Lasers and Light in Ophthalmology},
       volume = {5},
       number = {2},
       pages = {95 - 99},
       year = {1992}
    }
    

1991

  • Vogel, A. and Dlugos, C. and Nuffer, R. and Birngruber, R.: Optical properties of human sclera, and their consequences for transscleral laser applications. Lasers Surg Med, no. 11, pp. 331-40, 1991
    BibTeX
    @article{Vogel1991,
       author = {Vogel, A. and Dlugos, C. and Nuffer, R. and Birngruber, R.},
       title = {Optical properties of human sclera, and their consequences for transscleral laser applications},
       journal = {Lasers Surg Med},
       volume = {11},
       number = {4},
       pages = {331-40},
       note = {0196-8092 (Print)
    Journal Article},
       abstract = {The spectral dependence of the optical properties of human sclera adjacent to the limbus was investigated and related to the potentials of transscleral photocoagulation. The total transmission, absorption, and reflection, as well as the angular distribution of the transmitted and reflected light were measured at five laser wavelengths (442 nm, 514 nm, 633 nm, 804 nm, and 1,064 nm), both for noncontact and contact applications. Absorption and scattering coefficients were determined using the Kubelka-Munk model for light propagation through a scattering tissue. The scleral transmission is only 6% at 442 nm but increases to 35% at 804 nm and to 53% at 1,064 nm. The absorption is high at short wavelengths with 40% at 442 nm but it is only 6% at 804 nm and 1,064 nm. The reflection is generally higher than 40% and shows little wavelength dependence. The transmitted light is scattered diffusely at short wavelengths, but at 804 nm and 1,064 nm it exhibits a fairly narrow angular distribution in forward direction. Fiber contact leads to an increase of transmission, with a factor of 3.5 at 442 nm, of 2.0 at 804 nm, and 1.5 at 1,064 nm. Our results indicate that the diode laser (804 nm) and the Nd:YAG laser (1,064 nm) with contact delivery are best suited for transscleral photocoagulation.},
       keywords = {Absorption
    Humans
    Lasers/*therapeutic use
    Light
    Optics
    Scattering, Radiation
    Sclera/*anatomy & histology/physiology},
       year = {1991}
    }
    

1990

  • Vogel, A. and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.: Wirkungsmechanismen, Schadensreichweite und Reduzierung von Nebenwirkungen bei der intraokularen Nd:YAG-Laserchirurgie. Fortschritte der Ophthalmologie, no. 87, pp. 675-687, 1990
    BibTeX
    @article{Vogel1990,
       author = {Vogel, A. and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.},
       title = {Wirkungsmechanismen, Schadensreichweite und Reduzierung von Nebenwirkungen bei der intraokularen Nd:YAG-Laserchirurgie},
       journal = {Fortschritte der Ophthalmologie},
       volume = {87},
       number = {6},
       pages = {675-687},
       keywords = {Oeil pathologie
    Animal
    Prévention
    Physiopathologie
    Complication
    In vitro
    Cornée
    Oeil
    Néodyme
    Laser YAG
    Laser
    Chirurgie},
       year = {1990}
    }
    
  • Vogel, A. and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.: Intraocular Nd:YAG Laser Surgery: Damage Mechanism, Damage Range and Reduction of Collateral Effects.. IEEE J Quant Electr, no. 26, pp. 2240-2260, 1990
    BibTeX
    @article{Vogel1990,
       author = {Vogel, A. and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.},
       title = {Intraocular Nd:YAG Laser Surgery: Damage Mechanism, Damage Range and Reduction of Collateral Effects.},
       journal = {IEEE J Quant Electr},
       volume = {26},
       number = {12 Special Issue on Lasers in Biology and Medicine},
       pages = {2240-2260},
       year = {1990}
    }
    
  • Vogel, Alfred and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.: [Mechanism of action, scope of the damage and reduction of side effects in intraocular Nd:YAG laser surgery]. Fortschr Ophthalmol, no. 87, pp. 675-87, 1990
    BibTeX Link
    @article{Vogel1990,
       author = {Vogel, Alfred and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.},
       title = {[Mechanism of action, scope of the damage and reduction of side effects in intraocular Nd:YAG laser surgery]},
       journal = {Fortschr Ophthalmol},
       volume = {87},
       number = {6},
       pages = {675-87},
       note = {0723-8045 (Print)
    English Abstract
    Journal Article},
       abstract = {The damage mechanisms of intraocular Nd:YAG laser surgery and their respective damage ranges were investigated in vitro using bovine cornea specimens as a model tissue. The main damage mechanisms are plasma formation and expansion, emission of acoustic transients, and cavitation with jet formation. When a sequence of laser pulses is applied, the interaction of the acoustic transients with gas bubbles remaining from preceding laser exposures is also important. To distinguish the effects caused by the different physical mechanisms, laser pulses were aimed directly onto the corneal endothelium, and parallel to the cornea at various distances. Simultaneously, the cavitation bubble size was determined. The surface morphology and sections of the same lesions were studied by light and electron microscopy. The primary surgical mechanism is tissue evaporation by the laser plasma, whereas the collateral damage from single laser pulses is mainly caused by the cavitation and jet formation. The damage range after a 4-mJ laser pulse is 0.8 mm which is slightly larger than the corresponding cavitation bubble radius. The damage range of the acoustic transients produced by a 4-mJ laser pulse is several millimeters, when they can interact with small gas bubbles attached to the corneal endothelium. The damage range of the acoustic transients alone is smaller than that of cavitation as far as damage detected by light and scanning electron microscopy is concerned. However, on a subcellular level the acoustic transients may possibly cause damage up to a much larger distance. The damage range observed varies with the cube root of the laser pulse energy. A reduction of collateral effects therefore requires the use of small pulse energies. For energies of less than 1 mJ, the pulse duration has to be reduced to ensure plasma production. It is proposed to use low-energy picosecond pulses with moderate repetition rate instead of single nanosecond pulses to reduce collateral damage effects.},
       keywords = {Animals
    Cattle
    Endothelium, Corneal/*injuries/pathology
    Laser Surgery/*adverse effects/instrumentation
    Microscopy, Electron, Scanning},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2086418},
       year = {1990},
       type = {Journal Article}
    }
    

1989

  • Vogel, A. and Lauterborn, W. and Timm, R.: Optical and acoustic investigations of the dynamics of laser-produced cavitation bubbles near a solid boundary. J. Fluid Mech., no. 206, pp. 299 - 338, 1989
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Lauterborn, W. and Timm, R.},
       title = {Optical and acoustic investigations of the dynamics of laser-produced cavitation bubbles near a solid boundary},
       journal = {J. Fluid Mech.},
       volume = {206},
       pages = {299 - 338},
       year = {1989}
    }
    

1988

  • Vogel, A. and Lauterborn, W.: Time-resolved particle image velocimetry used in the investigation of cavitation bubble dynamics. Applied Optics, no. 27, pp. 1869 -1876, 1988
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Lauterborn, W.},
       title = {Time-resolved particle image velocimetry used in the investigation of cavitation bubble dynamics},
       journal = {Applied Optics},
       volume = {27},
       number = {09},
       pages = {1869 -1876},
       year = {1988}
    }
    
  • Vogel, A. and Lauterborn, W.: Acoustic transient generation by laser-produced cavitation bubbles near solid boundaries. J. Acoust. Soc. Am., no. 84, pp. 719 - 731, 1988
    BibTeX
    @article{Vogel1988,
       author = {Vogel, A. and Lauterborn, W.},
       title = {Acoustic transient generation by laser-produced cavitation bubbles near solid boundaries},
       journal = {J. Acoust. Soc. Am.},
       volume = {84},
       number = {2},
       pages = {719 - 731},
       year = {1988}
    }
    

1986

  • Vogel, A: Vergleich zweier empfindlicher Speckle-Meßtechniken angewandt auf Verformungsmessungen an Zähnen. Optik, no. 72, pp. 95-101, 1986
    BibTeX
    @article{Vogel,
       author = {Vogel, A},
       title = {Vergleich zweier empfindlicher Speckle-Meßtechniken angewandt auf Verformungsmessungen an Zähnen},
       journal = {Optik},
       volume = {72},
       pages = {95-101},
       note = {Journal Article},
       year = {1986}
    }
    
  • Vogel, A. and Hentschel, W. and Holzfuss, J. and Lauterborn, W.: Cavitation Bubble Dynamics and Acoustic Transient Generation in Ocular Surgery with Pulsed Neodymium: YAG Lasers. Ophthalmology, no. 93, pp. 1259 -1269, 1986
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Hentschel, W. and Holzfuss, J. and Lauterborn, W.},
       title = {Cavitation Bubble Dynamics and Acoustic Transient Generation in Ocular Surgery with Pulsed Neodymium: YAG Lasers},
       journal = {Ophthalmology},
       volume = {93},
       number = {10},
       pages = {1259 -1269},
       year = {1986}
    }
    

1985

  • Vogel, A and Lauterborn, W.: Ein Raumfrequenzfilterungsverfahren zur Untersuchung der Strömung um Kavitationsblasen. Optik, no. 69, pp. 176-179, 1985
    BibTeX
    @article{Vogel1985,
       author = {Vogel, A and Lauterborn, W.},
       title = { Ein Raumfrequenzfilterungsverfahren zur Untersuchung der Strömung um Kavitationsblasen},
       journal = {Optik},
       volume = {69},
       number = {4},
       pages = {176-179},
       note = {Journal Article},
       year = {1985}
    }
    

018

  • Uzunbajakava, N E; Varghese, B; Botchkareva, N V; Verhagen, R and Vogel, A: Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, no. 0492 ,, 018
    BibTeX Link
    @inproceedings{Vogel2018,
       author = {Uzunbajakava, N E; Varghese, B; Botchkareva, N V; Verhagen, R and Vogel, A},
       title = {Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions},
       booktitle = {Progress in Biomedical Optics and Imaging - Proceedings of SPIE},
       volume = {10492} ,
       DOI = {10.1117/12.2307804}
       year = {2018}
    date = {2018-20-02},
       type = {Conference Proceedings}
    }

  • Vogel, Alfred and Busch, Stefan and Asiyo-Vogel, Mary: Time-resolved measurements of shock-wave emission and cavitation-bubble generation in intraocular laser surgery with ps- and ns-pulses and related tissue effects. no. 1877, pp. 312-322,
    BibTeX Link
    @inproceedings{Vogel1993,
       author = {Vogel, Alfred and Busch, Stefan and Asiyo-Vogel, Mary},
       title = {Time-resolved measurements of shock-wave emission and cavitation-bubble generation in intraocular laser surgery with ps- and ns-pulses and related tissue effects},
       volume = {1877},
       pages = {312-322},
       note = {10.1117/12.147544},
       abstract = {Intraocular microsurgery relies on plasma generation with subsequent shock wave emission and cavitation bubble formation. To assess the potentials of photodisruption with picosecond pulses in comparison to the clinical techniques presently used, the shock wave characteristics and the bubble expension after optical breakdown with picosecond and nanosecond laser pulses were investigated by time resolved photography and acoustic measurements. Nd:YAG laser pulses with a wavelength of 1064 nm and a duration of 30 ps and 6 ns were focused into a water-filled glass cuvette. Their breakdown thresholds were 15 (mu) J and 200 (mu) J, respectively. Frequency doubled light from the same laser pulses was optically delayed between 2 ns and 136 ns and used as illumination source for photography. Since the individual events were well reproducible, the shock wave position and bubble wall position could be determined as a function of time. From the slope of these r(t) curves, the shock wave and bubble wall velocities were determined. The shock wave pressure p(r) was calculated from the shock velocity using the `jump conditions' of the shock front and the equation of state of water. The collateral effects of intraocular microsurgery can thus be considerably reduced by using ps-pulses, and with series of ps-pulses a `laser scalpel' may be realized which offers new applications of photodisruption.},
       url = {http://dx.doi.org/10.1117/12.147544},
       type = {Conference Proceedings}
    }
    
  • Vogel, A and Scammon, R.J. and Godwin, R.P.: Tensile stress generation by optical breakdown in tissue: experimental investigations and numerical simulations. in Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, no. 3601, pp. 191-206, Proc. SPIE,
    BibTeX
    @inproceedings{Vogel,
       author = {Vogel, A and Scammon, R.J. and Godwin, R.P.},
       title = {Tensile stress generation by optical breakdown in tissue: experimental investigations and numerical simulations},
       booktitle = {Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical},
       publisher = {Proc. SPIE},
       volume = {3601},
       pages = {191-206},
    
    }
    
  • Horneffer, V. and Vogel, A. and Sägmüller, B. and Schütze, K.: Microdissection, catapulting, and microinjection of biologic specimens with femtosecond laser pulses. in SPIE/OSA Conference on Biomedical Optics ECBO,12.-16.06.2005,
    BibTeX
    @inproceedings{Horneffer,
       author = {Horneffer, V. and Vogel, A. and Sägmüller, B. and Schütze, K.},
       title = {Microdissection, catapulting, and microinjection of biologic specimens with femtosecond laser pulses},
       booktitle = {SPIE/OSA Conference on Biomedical Optics ECBO,12.-16.06.2005},
    }
  • Apitz, Ingo and Vogel, Alfred: Material ejection in Q-switched Er:YAG laser ablation of water, liver, and skin. no. 4961, pp. 48-59, SPIE,
    BibTeX
    @inproceedings{Apitz,
       author = {Apitz, Ingo and Vogel, Alfred},
       title = {Material ejection in Q-switched Er:YAG laser ablation of water, liver, and skin},
       editor = {Steven, L. Jacques and Donald, D. Duncan and Sean, J. Kirkpatrick and Andres, Kriete},
       publisher = {SPIE},
       volume = {4961},
       pages = {48-59},
    }
    
  • Vogel, Alfred and Noack, Joachim and Nahen, Kester and Theisen, Dirk and Birngruber, Reginald and Hammer, Daniel X and Noojin, Gary D and Rockwell, Benjamin A: Laser-induced breakdown in the eye at pulse durations from 80 ns to 100 fs. in BiOS`98 International Biomedical Optics Symposium, pp. 34-49, International Society for Optics and Photonics,
    BibTeX
    @inproceedings{Vogel1998,
       author = {Vogel, Alfred and Noack, Joachim and Nahen, Kester and Theisen, Dirk and Birngruber, Reginald and Hammer, Daniel X and Noojin, Gary D and Rockwell, Benjamin A},
       title = {Laser-induced breakdown in the eye at pulse durations from 80 ns to 100 fs},
       booktitle = {BiOS'98 International Biomedical Optics Symposium},
       publisher = {International Society for Optics and Photonics},
       pages = {34-49},
       type = {Conference Proceedings}
    }
    
  • Vogel, Alfred and Venugopalan, Vasan: Kinetics of phase transitions in pulsed IR laser ablation of biological tissues. no. 4961, pp. 66-74, SPIE,
    BibTeX
    @inproceedings{Vogel,
       author = {Vogel, Alfred and Venugopalan, Vasan},
       title = {Kinetics of phase transitions in pulsed IR laser ablation of biological tissues},
       editor = {Steven, L. Jacques and Donald, D. Duncan and Sean, J. Kirkpatrick and Andres, Kriete},
       publisher = {SPIE},
       volume = {4961},
       pages = {66-74},
    }
    
  • Orzekowsky-Schroeder, Regina and Klinger, Antje and Schuth, Anna and Freidank, Sebastian and Huttmann, Gereon and Gebert, Andreas and Vogel, Alfred: Intravital real-time study of tissue response to controlled laser-induced cavitation using 500-ps UV laser pulses focused in murine gut mucosa under online dosimetry and spectrally resolved 2-photon microscopy. no. 7568, pp. 756815, SPIE,
    BibTeX
    @inproceedings{Orzekowsky2010,
       author = {Orzekowsky-Schroeder, Regina and Klinger, Antje and Schuth, Anna and Freidank, Sebastian and Huttmann, Gereon and Gebert, Andreas and Vogel, Alfred},
       title = {Intravital real-time study of tissue response to controlled laser-induced cavitation using 500-ps UV laser pulses focused in murine gut mucosa under online dosimetry and spectrally resolved 2-photon microscopy},
       editor = {Daniel, L. Farkas and Dan, V. Nicolau and Robert, C. Leif},
       publisher = {SPIE},
       volume = {7568},
       pages = {756815},
    
    }
  • Vogel, Alfred and Brujan, Emil A and Schmidt, Peter and Nahen, Kester: Interaction of Laser-Produced Cavitation Bubbles with Elastic Boundaries. in IUTAM Symposium on Free Surface Flows, pp. 327-335, Springer,
    BibTeX
    @inproceedings{Vogel2001,
       author = {Vogel, Alfred and Brujan, Emil A and Schmidt, Peter and Nahen, Kester},
       title = {Interaction of Laser-Produced Cavitation Bubbles with Elastic Boundaries},
       booktitle = {IUTAM Symposium on Free Surface Flows},
       publisher = {Springer},
       pages = {327-335},
       ISBN = {9401038546},
       type = {Conference Proceedings}
    }
    
  • Vogel, Alfred and Brujan, Emil A and Schmidt, Peter and Nahen, Kester: Interaction of laser-produced cavitation bubbles with an elastic tissue model. in BiOS 2001 The International Symposium on Biomedical Optics, pp. 167-177, International Society for Optics and Photonics,
    BibTeX
    @inproceedings{Vogel2001,
       author = {Vogel, Alfred and Brujan, Emil A and Schmidt, Peter and Nahen, Kester},
       title = {Interaction of laser-produced cavitation bubbles with an elastic tissue model},
       booktitle = {BiOS 2001 The International Symposium on Biomedical Optics},
       publisher = {International Society for Optics and Photonics},
       pages = {167-177},
       type = {Conference Proceedings}
    }
    
  • Vogel, Alfred and Nahen, Kester and Theisen, Dirk and Birngruber, Reginald and Thomas, Robert J and Rockwell, Benjamin A: Influence of optical aberrations on laser-induced plasma formation in water and their consequences for intraocular photodisruption. in BiOS`98 International Biomedical Optics Symposium, pp. 120-131, International Society for Optics and Photonics,
    BibTeX
    @inproceedings{Vogel1998,
       author = {Vogel, Alfred and Nahen, Kester and Theisen, Dirk and Birngruber, Reginald and Thomas, Robert J and Rockwell, Benjamin A},
       title = {Influence of optical aberrations on laser-induced plasma formation in water and their consequences for intraocular photodisruption},
       booktitle = {BiOS'98 International Biomedical Optics Symposium},
       publisher = {International Society for Optics and Photonics},
       pages = {120-131},
       type = {Conference Proceedings}
    }
    
  • Hillmann, Dierck and Luhrs, Christian and Bonin, Tim and Koch, Peter and Vogel, Alfred and Huttmann, Gereon: Holoscopy: holographic optical coherence tomography. no. 8091, pp. 80911H, Proc. SPIE,
    BibTeX Link
    @inproceedings{Hillmann2011,
       author = {Hillmann, Dierck and Luhrs, Christian  and Bonin, Tim  and Koch, Peter and Vogel, Alfred  and Huttmann, Gereon },
       title = {Holoscopy: holographic optical coherence tomography},
       editor = {Rainer, A. Leitgeb and Brett, E. Bouma},
       publisher = {Proc. SPIE},
       volume = {8091},
       pages = {80911H},
       url = {http://link.aip.org/link/?PSI/8091/80911H/1
    http://dx.doi.org/10.1117/12.889485},
       type = {Conference Proceedings}
    }
    
  • Vogel, A. and Noack, J. and Hüttmann, G. and Linz, N. and Freidank, S. and Paltauf, G.: Femtosecond laser nanosurgery of biological cells and tissues. in 4th International Congress on Laser Advanced Materials Processing,
    BibTeX
    @inproceedings{Vogel2006,
       author = {Vogel, A. and Noack, J. and Hüttmann, G. and Linz, N. and Freidank, S. and Paltauf, G.},
       title = {Femtosecond laser nanosurgery of biological cells and tissues},
       booktitle = {4th International Congress on Laser Advanced Materials Processing}
    }
  • Guerra III, Arnold and Venugopalan, Vasan and Nahen, Kester and Vogel, Alfred: Experimental investigation of optical breakdown using nanosecond 532-nm and 1064-nm laser pulses delivered at high numerical aperture. in BiOS 2001 The International Symposium on Biomedical Optics, pp. 74-82, International Society for Optics and Photonics,
    BibTeX
    @inproceedings{Guerra2001,
       author = {Guerra III, Arnold and Venugopalan, Vasan and Nahen, Kester and Vogel, Alfred},
       title = {Experimental investigation of optical breakdown using nanosecond 532-nm and 1064-nm laser pulses delivered at high numerical aperture},
       booktitle = {BiOS 2001 The International Symposium on Biomedical Optics},
       publisher = {International Society for Optics and Photonics},
       pages = {74-82},
       type = {Conference Proceedings}
    }
    
  • Vogel, Alfred and Noack, Joachim and Nahen, Kester and Theisen, Dirk and Busch, Stefan and Parlitz, Ulrich and Hammer, Daniel X and Noojin, Gary D and Rockwell, Benjamin A and Birngruber, Reginald: Energy balance of optical breakdown in water. in BiOS`98 International Biomedical Optics Symposium, pp. 168-179, International Society for Optics and Photonics,
    BibTeX
    @inproceedings{Vogel1998,
       author = {Vogel, Alfred and Noack, Joachim and Nahen, Kester and Theisen, Dirk and Busch, Stefan and Parlitz, Ulrich and Hammer, Daniel X and Noojin, Gary D and Rockwell, Benjamin A and Birngruber, Reginald},
       title = {Energy balance of optical breakdown in water},
       booktitle = {BiOS'98 International Biomedical Optics Symposium},
       publisher = {International Society for Optics and Photonics},
       pages = {168-179},
       type = {Conference Proceedings}
    }
    
  • Brujan, Emil-Alexandru and Nahen, Kester and Schmidt, Peter and Vogel, Alfred: Dynamics of laser-induced cavitation bubbles near an elastic boundary used as a tissue phantom. in NONLINEAR ACOUSTICS AT THE TURN OF THE MILLENNIUM: ISNA 15, 15th International Symposium, no. 524, pp. 381-384, AIP Publishing,
    BibTeX
    @inproceedings{Brujan2000,
       author = {Brujan, Emil-Alexandru and Nahen, Kester and Schmidt, Peter and Vogel, Alfred},
       title = {Dynamics of laser-induced cavitation bubbles near an elastic boundary used as a tissue phantom},
       booktitle = {NONLINEAR ACOUSTICS AT THE TURN OF THE MILLENNIUM: ISNA 15, 15th International Symposium},
       publisher = {AIP Publishing},
       volume = {524},
       pages = {381-384},
       ISBN = {0094-243X},
       type = {Conference Proceedings}
    }
    
  • Brinkmann, Ralf and Kampmeier, Juergen and Grotehusmann, Ulf and Vogel, Alfred and Koop, Norbert and Asiyo-Vogel, Mary and Birngruber, Reginald: Corneal collagen denaturation in laser thermokeratoplasty. no. 2681, pp. 56-63,
    BibTeX Link
    @inproceedings{Brinkmann1996,
       author = {Brinkmann, Ralf and Kampmeier, Juergen and Grotehusmann, Ulf and Vogel, Alfred and Koop, Norbert and Asiyo-Vogel, Mary and Birngruber, Reginald},
       title = {Corneal collagen denaturation in laser thermokeratoplasty},
       volume = {2681},
       pages = {56-63},
       note = {10.1117/12.239611},
       abstract = {In laserthermokeratoplasty (LTK) thermal denaturation and shrinkage of corneal collagen is used to correct hyperopia and astigmatism. In order to optimize dosimetry, the temperature at which maximal shrinkage of collagen fibrils occurs is of major interest. Since the exposure time in clinical LTK-treatment is limited to a few seconds, the kinetics of collagen denaturation as a rate process has to be considered, thus the time of exposure is of critical importance for threshold and shrinkage temperatures. We investigated the time-temperature correlation for corneal collagen denaturation within different time domains by turbidimetry of scattered HeNe laser probe light using a temperature controlled water bath and pulsed IR laser irradiation. In the temperature range of 60 degree(s)C to 95 degree(s)C we found an exponential relation between the denaturation time and temperature. For the typical LTK-treatment time of 2 s, a temperature of 95 degree(s)C is needed to induce thermal damage. Use of pulsed Holmium laser radiation gave significant scattering of HeNe laser probe light at calculated temperatures of around 100 degree(s)DC. Rate parameters according to the formalism of Arrhenius were fitted to these results. Force measurements showed the simultaneous onset of light scattering and collagen shrinkage.},
       url = {http://dx.doi.org/10.1117/12.239611},
       type = {Conference Proceedings}
    }
    
  • Godwin, Robert P. and Chapyak, Edward J. and Noack, J. and Vogel, A.: Aspherical bubble dynamics and oscillation times. pp. CTuC3, Optical Society of America,
    BibTeX
    @inproceedings{Godwin,
       author = {Godwin, Robert P. and Chapyak, Edward J. and Noack, J. and Vogel, A.},
       title = {Aspherical bubble dynamics and oscillation times},
       series = {OSA Technical Digest},
       publisher = {Optical Society of America},
       pages = {CTuC3},
    }
    
  • Nahen, Kester and Vogel, Alfred: Acoustic spectroscopy of Er: YAG laser ablation of skin: first results. in BiOS`98 International Biomedical Optics Symposium, pp. 218-229, International Society for Optics and Photonics,
    BibTeX
    @inproceedings{Nahen1998,
       author = {Nahen, Kester and Vogel, Alfred},
       title = {Acoustic spectroscopy of Er: YAG laser ablation of skin: first results},
       booktitle = {BiOS'98 International Biomedical Optics Symposium},
       publisher = {International Society for Optics and Photonics},
       pages = {218-229},
       type = {Conference Proceedings}
    }
    
  • Nahen, Kester and Vogel, Alfred: Acoustic signal characteristics during IR laser ablation and their consequences for acoustic tissue discrimination. in BiOS 2000 The International Symposium on Biomedical Optics, pp. 166-176, International Society for Optics and Photonics,
    BibTeX
    @inproceedings{Nahen2000,
       author = {Nahen, Kester and Vogel, Alfred},
       title = {Acoustic signal characteristics during IR laser ablation and their consequences for acoustic tissue discrimination},
       booktitle = {BiOS 2000 The International Symposium on Biomedical Optics},
       publisher = {International Society for Optics and Photonics},
       pages = {166-176},
       type = {Conference Proceedings}
    }
    
  • Hoerauf, H. and Brix, A. and Scholz, C. and Winkler, J. and Droge, G. and Birngruber, R. and Vogel, A. and Laqua, H.: [Retinal photoablation with the Erbium:YAG laser. Initial experimental results for traction-free removal of tissue]. Ophthalmologe, no. 100, pp. 115-21, Feb,
    BibTeX
    @article{Hoerauf,
       author = {Hoerauf, H. and Brix, A. and Scholz, C. and Winkler, J. and Droge, G. and Birngruber, R. and Vogel, A. and Laqua, H.},
       title = {[Retinal photoablation with the Erbium:YAG laser. Initial experimental results for traction-free removal of tissue]},
       journal = {Ophthalmologe},
       volume = {100},
       number = {2},
       pages = {115-21},
       note = {0941-293X (Print)
    Comparative Study
    English Abstract
    Journal Article},
       month = {Feb},
       abstract = {BACKGROUND: To investigate the potential of an Er:YAG laser for precise and traction-free removal of retinal layers in vitro. MATERIAL AND METHODS: Retinal ablation in porcine retinal explants was performed using a free running Er:YAG laser focused either into a low-OH quartz fiber or a sapphire fiber. The explants were treated under air or perfluorodecaline (PFD). The ablation depth was evaluated by optical coherence tomography (OCT) and histology sections. RESULTS: A radiant exposure of 5.0 J/cm(2) under air and PFD resulted in complete transsection of the neurosensory retina.Between 3.5 and 2.0 J/cm(2) the ablation depth and the defect patterns varied markedly and adjacent thermal zones areas were seen. Below 2.0 J/cm(2) no defects could be created in air, whereas under PFD the ablation extended into the ganglion cell layer. Ablations using a sapphire fiber and 2.0 J/cm(2) showed a significantly higher reproducibility of ablation depth, and homogeneous defect patterns limited to the nerve fiber layer could be produced without thermal damage. CONCLUSIONS: The Er:YAG laser system with a low-OH quartz fiber allowed ablation of inner retinal layers in vitro, but revealed a variable ablation depth and low reproducibility.However, a sapphire fiber showed markedly improved results. Therefore its use during vitreoretinal surgery seems possible not only as a cutting device but also as a tool for the ablation of fine retinal structures.},
       keywords = {Animals
    Erbium
    Fluorocarbons
    Laser Surgery/*methods
    *Ophthalmologic Surgical Procedures
    Retina/anatomy & histology/*surgery
    Swine