Dr. Birgit Lange

Wissenschaftliche Mitarbeiterin

AG Brinkmann

Peter-Monnik-Weg 4
23562 Lübeck

Gebäude 82,

Email:
Phone:
+49 451 3101 3286
Fax:
+49 451 3101 3204

Publikationen

2020

  • Strittmatter, Frank;Eisel, Maximilian;Brinkmann, Ralf;Cordes, Jens;Lange, Birgit and Sroka, Ronald: Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned. Translational Biophotonics, no. n/a, pp. e201900029, 2019
    BibTeX Link Link
    @article{Brinkmann2020,
       author = {Strittmatter, F;Eisel, M; Brinkmann, R; Cordes, J;Lange, B and Sroka, R},
       title = {Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned},
       journal = {Translational Biophotonics},
       volume = {n/a},
       number = {n/a},
       pages = {e201900029},
       ISSN = {2627-1850},
       DOI = {10.1002/tbio.201900029},
       url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/tbio.201900029},
       year = {2019},
       type = {Journal Article}
    }
    

2017

  • Lange, Birgit and Jocham, Dieter and Brinkmann, Ralf and Cordes, Jens: Stone/tissue differentiation for Holmium laser lithotripsy using autofluorescence: Clinical proof of concept study. Lasers in Surgery and Medicine, no. 49, pp. 361-365, 2017
    BibTeX Link
    @article{Lange2017,
       author = {Lange, Birgit and Jocham, Dieter and Brinkmann, Ralf and Cordes, Jens},
       title = {Stone/tissue differentiation for Holmium laser lithotripsy using autofluorescence: Clinical proof of concept study},
       journal = {Lasers in Surgery and Medicine},
       volume = {49},
       number = {4},
       pages = {361-365},
       ISSN = {1096-9101},
       DOI = {10.1002/lsm.22611},
       year = {2017},
       type = {Journal Article}
    }
    

2015

  • Lange, B. and Cordes, J. and Brinkmann, R.: Stone/tissue differentiation for holmium laser lithotripsy using autofluorescence. Lasers Surg Med, no. 47, pp. 737-44, 2015
    BibTeX Link
    @article{Lange2015,
       author = {Lange, B. and Cordes, J. and Brinkmann, R.},
       title = {Stone/tissue differentiation for holmium laser lithotripsy using autofluorescence},
       journal = {Lasers Surg Med},
       volume = {47},
       number = {9},
       pages = {737-44},
       note = {1096-9101
    Lange, Birgit
    Cordes, Jens
    Brinkmann, Ralf
    Journal Article
    United States
    Lasers Surg Med. 2015 Nov;47(9):737-44. doi: 10.1002/lsm.22418. Epub 2015 Sep 22.},
       abstract = {BACKGROUND AND OBJECTIVES: Holmium laser lithotripsy is a safe and effective method to disintegrate urinary stones of all compositions in an endoscopic procedure. However, handling and safety could be improved by a real-time feedback system permanently monitoring the position of the treatment fiber. The laser is fired only when the fiber is identified as being placed in front of stone. This work evaluates the potential of fluorescence detection with an excitation wavelength of 532 nm for this purpose. MATERIALS AND METHODS: A fiber-based fluorescence measurement was set-up to acquire autofluorescence signals from several human renal calculi, artificial stones, and porcine tissue samples (renal calix and ureter). Three different approaches were investigated. First, experiments were performed with a pulsed laser source with a wavelength of 532 nm, pulse energy 36.5 +/- 1 muJ, pulse duration 1.2 +/- 0.5 nanoseconds, and a repetition rate of 1 kHz with 15 urinary concretions. In the second step, a series of measurements on 42 human urinary calculi samples was carried out using low power continuous wave excitation of 0.4 +/- 0.1 mW. Fluorescence was also measured simultaneously to stone fragmentation by holmium laser pulses (pulse energy 240 +/- 50 mJ, repetition rate 10 Hz). Finally, a modulated excitation/detection scheme (lock-in technique) was implemented to render fluorescence detection insensitive to white background light. RESULTS: Unlike porcine renal calix, ureter, and artificial stone human urinary calculi show a strong fluorescence signal when excited with 532 nm. With pulsed excitation on urinary stone (20,000 +/- 11,000) counts were registered at 587 nm with the CCD-array of a grating spectrometer in an integration time of 50 milliseconds. Tissue gave lower count rates of </=(5,500 +/- 1,100) even with longer integration times (500 milliseconds/1 second). With a cw excitation power of 0.4 mW (13,000 +/- 11,000) counts were registered in an integration time of 200 milliseconds at 587 nm (porcine renal calix: (770 +/- 340)). Modulated excitation (66 Hz) with an average power of 0.3 mW and detection with a photodiode resulted in a lock-in amplifier signal of 1.5-4.3V on stone (background and skin: <0.5V). CONCLUSION: With the lock-in technique, autofluorescence from stones can be detected with only the average excitation power of a green aiming beam overlaid to the Ho:YAG-laser beam (power </= 1 mW). Since tissue shows very little autofluorescence when excited with 532 nm, this fluorescence signal enables monitoring of the correct position of the treatment fiber during ureteroscopic procedures. Lasers Surg. Med. 47:737-744, 2015. (c) 2015 Wiley Periodicals, Inc.},
       keywords = {Holmium laser
    feedback control
    fluorescence
    laser lithotripsy},
       ISSN = {0196-8092},
       DOI = {10.1002/lsm.22418},
       year = {2015},
       type = {Journal Article}
    }
    
  • Huttmann, Gereon and Koinzer, Stefan Otto Johannes and Müller, Heike and Ellerkamp, Iris and Baade, Alex and Moltmann, Moritz and Theisen-Kunde, Dirk and Lange, Birgit and Brinkmann, Ralf and Birngruber, Reginald: Predicting ophthalmoscopic visibility of retinal photocoagulation lesions byhigh-speedOCT: an animal studyinrabbits. Investigative Ophthalmology & Visual Science, no. 56, pp. 5980-5980, 2015
    BibTeX
    @article{Hüttmann2015,
       author = {Huttmann, Gereon and Koinzer, Stefan Otto Johannes and Müller, Heike and Ellerkamp, Iris and Baade, Alex and Moltmann, Moritz and Theisen-Kunde, Dirk and Lange, Birgit and Brinkmann, Ralf and Birngruber, Reginald},
       title = {Predicting ophthalmoscopic visibility of retinal photocoagulation lesions byhigh-speedOCT: an animal studyinrabbits},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {56},
       number = {7},
       pages = {5980-5980},
       ISSN = {1552-5783},
       year = {2015},
       type = {Journal Article}
    }
    

2013

  • Cordes, Jens and Nguyen, Felix and Lange, Birgit and Brinkmann, Ralf and Jocham, Dieter: Damage of Stone Baskets by Endourologic Lithotripters: A Laboratory Study of 5 Lithotripters and 4 Basket Types. Advances in Urology, no. 2013, pp. 6, 2013
    BibTeX Link
    @article{Cordes2013,
       author = {Cordes, Jens and Nguyen, Felix and Lange, Birgit and Brinkmann, Ralf and Jocham, Dieter},
       title = {Damage of Stone Baskets by Endourologic Lithotripters: A Laboratory Study of 5 Lithotripters and 4 Basket Types},
       journal = {Advances in Urology},
       volume = {2013},
       pages = {6},
       DOI = {10.1155/2013/632790},
       url = {http://dx.doi.org/10.1155/2013/632790},
       year = {2013},
       type = {Journal Article}
    }