Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Christian
Hagel,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Heinz
Handels,
Ralf
Brinkmann, and
Robert
Huber,
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
DOI: | 10.3389/fonc.2022.896060 |
Bibtex: | @article{Strenge-2022, author = {Strenge, P.;Lange, B.;Grill,C.;Danicke,V.;Theisen-Kunde, D.;Hagel, C.;Spahr-Hess, S.;;Bonsanto, Matteo M.;Handels, H.; and Huber, R.;Brinkmann, R.}, title = {Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology}, journal = {Frontiers in Oncology}, Keywords = {AG-Huber_FDML, AG-Huber_OCT, brain, tumor, glioblastoma multiforme, OCT, neural network, attenuation (absorption) coefficient, optical coherence tomography}, DOI = {https://doi.org/10.3389/fonc.2022.896060}, url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.896060/full}, year = {2022}, type = {Journal Article} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Christian
Hagel,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
DOI: | 10.1088/1361-6560/ac6d9d |
Bibtex: | @article{Strenge2022, author = {Strenge, P;Lange, B;Grill, C;Draxinger, W;Danicke, V;Theisen-Kunde, D;Hagel, C;Spahr-Hess, S;Bonsanto, Matteo M.;Huber, R;Handels, H and Brinkmann, R}, title = {Registration of histological brain images onto optical coherence tomography images based on shape information}, keywords = {brain, glioblastoma multiforme, shape, OCT, optical coherence tomography, AG-Huber_OCT,}, journal = {Physics in Medicine & Biology}, ISSN = {0031-9155}, url = {http://iopscience.iop.org/article/10.1088/1361-6560/ac6d9d}, year = {2022}, type = {Journal Article} } |
Konstantin
Yashin,
Matteo Mario
Bonsanto,
Ksenia
Achkasova,
Anna
Zolotova,
Al-Madhaji
Wael,
Elena
Kiseleva,
Alexander
Moiseev,
Igor
Medyanik,
Leonid
Kravets,
Robert
Huber,
Ralf
Brinkmann, and
Natalia
Gladkova,
OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives, Diagnostics , vol. 12, no. 2, pp. 335, 01 2022.
OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives, Diagnostics , vol. 12, no. 2, pp. 335, 01 2022.
DOI: | 10.3390/diagnostics12020335 |
Datei: | 335 |
Bibtex: | @article{Yashin-2022, author = {Yashin, K;Bonsanto, M M;Achkasova, K;Zolotova, A;Wael, Al-M;Kiseleva, E;Moiseev, A;Medyanik, I;Kravets, L;Huber, R;Brinkmann, R and Gladkova, N}, title = {OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives}, journal = {Diagnostics}, volume = {12}, number = {2}, pages = {335}, ISSN = {2075-4418}, keywords = {AG-Huber; optical coherence tomography; brain imaging; neurosurgical guidance; brain tumor; minimally invasive theranostics; intraoperative imaging}, url = {https://www.mdpi.com/2075-4418/12/2/335}, year = {2022}, type = {Journal Article} } |
Birgit
Lange,
Tomasz
Ozimek,
Judith R.
Wießmeyer,
Mario W.
Kramer,
Axel S.
Merseburger, and
Ralf
Brinkmann,
Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy, Biomedical Physics & Engineering Express , vol. 8, no. 5, pp. 055023, 2022.
Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy, Biomedical Physics & Engineering Express , vol. 8, no. 5, pp. 055023, 2022.
DOI: | 10.1088/2057-1976/ac82c7 |
Bibtex: | @article{Lange2022, author = {Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W.;Merseburger, A S. and Brinkmann, R}, title = {Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy}, journal = {Biomedical Physics & Engineering Express}, volume = {8}, number = {5}, abstract = {Objectives. In laser lithotripsy, a green aiming beam overlying the infrared (IR) treatment radiation gives rise to reflection and fluorescence signals that can be measured via the treatment fiber. While stone autofluorescence is used for target detection, the condition of the fiber can be assessed based on its Fresnel reflection. For good applicability, fluorescence detection of stones should work even when the stone and fiber are not in direct contact. Fiber breakage detection, on the other hand, can be falsified if surfaces located in front of the fiber reflect light from the aiming laser back into it. For both applications, therefore, a fundamental investigation of the dependence of the signal amplitude on the distance between fiber and surface is important. Methods. Calculations of the signal drop of fluorescence or diffuse and specular reflection with increasing fiber distance were performed using ray tracing based on a simple geometric model for different fiber core diameters. Reflection signals from a mirror, diffuse reflector, human calculi, and porcine renal tissue placed in water were measured at varying distances (0–5 mm). For human calculi, fluorescence signals were recorded simultaneously. Results. The calculations showed a linear signal decrease down to ∼60% of the maximum signal (fiber in contact). The distance z at which the signal drops to for example 50% depends linearly on the diameter of the fiber core. For fibers used in lithotripsy and positioned in water, z50% ranges from 0.55 mm (200 μm core diameter) to 2.73 mm, (1 mm core diameter). The calculations were in good agreement with the experimental results. Conclusions. The autofluorescence signals of stones can be measured in non-contact mode. Evaluating the Fresnel signal of the end face of the fiber to detect breakage is possible unless the fiber is situated less than some millimeters to reflecting surfaces.}, keywords = {urolithiasis, laser lithotripsy, fluorescence, reflectance}, pages = {055023}, ISSN = {2057-1976}, DOI = {10.1088/2057-1976/ac82c7}, year = {2022}, type = {Journal Article} } |
Yoko
Miura,
Keiji
Inagaki,
Alessa
Hutfilz,
Eric
Seifert,
Benedikt
Schmarbeck,
Akira
Murakami,
Kishiko
Ohkoshi, and
Ralf
Brinkmann,
Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application, Life , vol. 12(9), pp. 1313, 2022.
Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application, Life , vol. 12(9), pp. 1313, 2022.
DOI: | https://doi.org/10.3390/life12091313 |
Datei: | 1313 |
Bibtex: | @article{Miura2022, author = {Miura, Y;Inagaki, K;Hutfilz, A;Seifert, E;Schmarbeck, B;Murakami, A;Ohkoshi, K and Brinkmann, R}, title = {Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application}, journal = {Life}, volume = {12(9)}, pages = {1313}, ISSN = {2075-1729}, url = {https://www.mdpi.com/2075-1729/12/9/1313}, year = {2022}, type = {Journal Article} } |
Manuel A.
Schaller,
Mitsuru
Wilson,
Viktoria
Kleymann,
Mario
Mordmüller,
Ralf
Brinkmann,
Matthias A.
Müller, and
Karl
Worthmann,
Parameter estimation and model reduction for model predictive control in retinal laser treatment, Control Engineering Practice , vol. 128, pp. 105320, 2022.
Parameter estimation and model reduction for model predictive control in retinal laser treatment, Control Engineering Practice , vol. 128, pp. 105320, 2022.
DOI: | https://doi.org/10.1016/j.conengprac.2022.105320 |
Bibtex: | @article{Schaller2022, author = {Schaller, M;Wilson, M;Kleyman, V;Mordmüller, M;Brinkmann, R;Müller, M. A. and Worthmann, K}, title = {Parameter estimation and model reduction for model predictive control in retinal laser treatment}, journal = {Control Engineering Practice}, volume = {128}, pages = {105320}, ISSN = {0967-0661}, DOI = {https://doi.org/10.1016/j.conengprac.2022.105320}, year = {2022}, type = {Journal Article} } |
Manuel A.
Schaller,
Viktoria
Kleymann,
Mario
Mordmüller,
Schmidt
Christian,
Mitsuru
Wilson,
Ralf
Brinkmann,
Matthias A.
Müller, and
Karl
Worthmann,
Model predictive control for retinal laser treatment at 1 kHz, at - Automatisierungstechnik , vol. 70(11), pp. 992-1002, 2022.
Model predictive control for retinal laser treatment at 1 kHz, at - Automatisierungstechnik , vol. 70(11), pp. 992-1002, 2022.
Datei: | auto-2022-0030 |
Bibtex: | @article{Schaller2022, author = {Schaller, M.;Kleyman, K.;Mordmüller, M.;Schmidt, C.;Wilson, M.;Brinkmann, R.;Müller, M.A. and Worthmann, K.}, title = {Model predictive control for retinal laser treatment at 1 kHz}, journal = {at - Automatisierungstechnik}, volume = {70(11)}, keywords = {model predictive control; real-time control;retinal photocoagulation}, pages = {992-1002}, url = {https://doi.org/10.1515/auto-2022-0030}, year = {2022}, type = {Journal Article} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dez.2021. pp. EW1C.7.
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dez.2021. pp. EW1C.7.
DOI: | 10.1117/12.2616044 |
Bibtex: | @inproceedings{Strenge:21, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography}, pages = {EW1C.7}, publisher = {Optical Society of America}, title = {Comparison of two optical coherence tomography systems to identify human brain tumor}, year = {2021}, url = {https://doi.org/10.1117/12.2616044}, abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.}, } |
Nicolas
Detrez,
Katharina
Rewerts,
Moritz
Matthiae,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dez.2021. pp. EW4A.10.
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dez.2021. pp. EW4A.10.
Weblink: | https://opg.optica.org/abstract.cfm?uri=ECBO-2021-EW4A.10 |
Bibtex: | @inproceedings{Detrez:21, author = {N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlueter, M.M. Bonsanto, D. Theisen-Kunde and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {EW4A.10}, publisher = {Optical Society of America}, title = {Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography}, year = {2021}, url = {https://doi.org/10.1117/12.2615022}, abstract = {A precision air puff excitation system for MHz Optical Coherence Elastography in neurosurgery was developed. It enables non-contact soft-tissue excitation down to {\textmu}N, with direct, noncontact force determination via gas flow measurement.}, } |
Katharina
Rewerts,
Moritz
Matthiae,
Nicolas
Detrez,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dez.2021. pp. ETh3A.3.
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dez.2021. pp. ETh3A.3.
Weblink: | https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETh3A.3 |
Bibtex: | @inproceedings{Rewerts2021ECBO, author = {K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlueter, M.M. Bonsanto, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {ETh3A.3}, publisher = {Optical Society of America}, title = {Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation}, year = {2021}, url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-ETh3A.3}, abstract = {Tumor discrimination from healthy tissue is often performed by haptically probing tissue elasticity. We demonstrate non-contact elastography using air-puff excitation and tissue indentation measurement by phase-sensitive OCT with a 3.2 MHz FDML-laser.}, } |
Hubertus
Hakert,
Matthias
Eibl,
Marie
Tillich,
Ralph
Pries,
Gereon
Hüttmann,
Ralf
Brinkmann,
Barbara
Wollenberg,
Ludwig
Bruchhage,
Sebastian
Karpf, and
Robert
Huber,
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
DOI: | 10.1364/OL.424726 |
Bibtex: | @article{Hakert2021, author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber}, title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1}, journal = {Optics Letters}, volume = {46(14)}, number = {14}, pages = {3456-3459}, keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering}, DOI = {https://doi.org/10.1364/OL.424726}, year = {2021}, type = {Journal Article} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
DOI: | 10.1117/12.2578409 |
Bibtex: | @inproceedings{Strenge2021A, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, title = {{Characterization of brain tumor tissue with 1310 nm optical coherence tomography}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {74 -- 80}, abstract = {The separation of tumorous brain tissue and healthy brain tissue is still a big challenge in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. On the basis of a recently created labelled OCT dataset of ex vivo glioblastoma multiforme tumor samples the detection of brain tumor tissue and the identification of zones with varying degrees of infiltration of tumor cells was investigated. The identification was based on the optical properties, which were extracted by an exponential fit function. The results showed that a separation of tumorous tissue and healthy white matter based on these optical properties is possible. A support vector machine was trained on the optical properties to separate tumor from healthy white matter tissue, which achieved a sensitivity of 91% and a specificity of 76% on an independent training dataset.}, keywords = {AG-Huber_OCT, optical coherence tomography, OCT, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578409} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Christian
Hagel,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
DOI: | 10.1117/12.2578391 |
Bibtex: | @inproceedings{Strenge2021, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann}, title = {{Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {66 -- 73}, abstract = {Optical coherence tomography (OCT) has the potential to become an additional imaging modality for surgical guidance in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. Interpretation of the images, however, is still a big challenge. A method to create a labeled OCT dataset based on ex vivo brain samples is introduced. The tissue samples were embedded in an agarose mold giving them a distinctive shape before images were acquired with two OCT systems (spectral domain (SD) and swept source (SS) OCT) and histological sections were created and segmented by a neuropathologist. Based on the given shape, the corresponding OCT images for each histological image can be determined. The transfer of the labels from the histological images onto the OCT images was done with a non-affine image registration approach based on the tissue shape. It was demonstrated that finding OCT images of a tissue sample corresponding to segmented histological images without any color or laser marking is possible. It was also shown that the set labels can be transferred onto OCT images. The accuracy of method is 26 ± 11 pixel, which translates to 192 ± 75 μm for the SS-OCT and 94 ± 43 μm for the SD-OCT. The dataset consists of several hundred labeled OCT images, which can be used to train a classification algorithm.}, keywords = {AG-Huber_OCT, optical coherence tomography, OCT, image registration, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery}, year = {2021}, URL = {https://doi.org/10.1117/12.2578391} } |
Elisabeth
Richert,
Julia
Papenkort,
Claus
von der Burchard,
Alexa
Klettner,
Patrik
Arnold,
Ralph
Lucius,
Ralf
Brinkmann,
Carsten
Framme,
Johann
Roider, and
Jan
Tode,
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Datei: | s12886-021-02188-8 |
Bibtex: | @article{Richert2021, title = {Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy}, author = {Richert, E;Papenkort, J;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Framme, C;Roider, J and Tode, J}, year = 2021, journal = {BMC Ophthalmology}, volume = {21(1)}, pages = 412, issn = {1471-2415}, url = {https://doi.org/10.1186/s12886-021-02188-8}, keywords = {Selective retina therapy (SRT), Thermal stimulation of the retina (TSR), Age- related macular degeneration (AMD), Regeneration, Rejuvenation}, type = {Journal Article} } |
Akika
Kyo,
Manabu
Yamamoto,
Kumiko
Hirayama,
Takeya
Kohno,
Dirk
Theisen-Kunde,
Ralf
Brinkmann,
Yoko
Miura, and
Shigeru
Honda,
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
DOI: | 10.1038/s41598-021-88372-8 |
Bibtex: | @article{Kyo-2021, author = {Kyo, A.;Yamamoto, M.;Hirayama, K.;Kohno, T.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.}, title = {Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy}, journal = {Sci Rep}, volume = {11(1)}, pages = {8973}, ISSN = {2045-2322}, DOI = {10.1038/s41598-021-88372-8}, year = {2021}, type = {Journal Article} } |
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Mario
Mordmüller,
Ralf
Brinkmann,
Karl
Worthmann, and
Matthias A.
Müller,
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
DOI: | https://doi.org/10.1016/j.ifacol.2021.08.552 |
Datei: | S2405896321013276 |
Bibtex: | @article{Kleyman2021, author = {Kleyman, V;Schaller, M;Wilson, M;Mordmüller, M;Brinkmann, R;Worthmann, K and Müller, M.A.}, title = {State and parameter estimation for model-based retinal laser treatment⁎⁎The collaborative project ”Temperature controlled retinal laser treatment” is funded by the German Research Foundation (DFG) under the project number 430154635 (MU 3929/3-1, WO 2056/7-1, BR 1349/6-1). MS was also funded by the DFG (grant WO 2056/2-1, project number 289034702). KW gratefully acknowledges funding by the German Research Foundation (DFG; grant WO 2056/6-1, project number 406141926)}, journal = {IFAC-PapersOnLine}, volume = {54(6)}, pages = {244-250}, ISSN = {2405-8963}, DOI = {https://doi.org/10.1016/j.ifacol.2021.08.552}, url = {https://www.sciencedirect.com/science/article/pii/S2405896321013276}, year = {2021}, type = {Journal Article} } |
Eric
Seifert,
Jan
Tode,
Amelie
Pielen,
Dirk
Theisen-Kunde,
Carsten
Framme,
Johann
Roider,
Yoko
Miura,
Reginald
Birngruber, and
Ralf
Brinkmann,
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Datei: | S2213597921000756 |
Bibtex: | @article{Seifert2021, author = {Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R}, title = {Algorithms for optoacoustically controlled selective retina therapy (SRT)}, journal = {Photoacoustics}, Keywords = {SRT; Lasers in medicine; Ophthalmology; RPE; Selectivity; Algorithm; Retina therapy; Optoacoustics; Feedback}, volume = {25}, pages = {100316}, ISSN = {2213-5979}, url = {https://www.sciencedirect.com/science/article/pii/S2213597921000756}, year = {2021}, type = {Journal Article} } |
Christian
Burri,
Alessa
Hutfilz,
Lorenz
Grimm,
Simon
Salzmann,
Patrik
Arnold,
Boris
Považay,
Christoph
Meier,
Andreas
Ebneter,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
DOI: | https://doi.org/10.3390/app11125535 |
Datei: | 5535 |
Bibtex: | @article{Burri2021, author = {Burri, C;Hutfilz, A;Grimm, L;Salzmann, S;Arnold, P;Považay, B;Meier, C;Ebneter, A;Theisen-Kunde, D and Brinkmann, R}, title = {Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery}, journal = {Applied Sciences}, volume = {11(12)}, pages = {5535}, ISSN = {2076-3417}, DOI = { https://doi.org/10.3390/app11125535}, url = {https://www.mdpi.com/2076-3417/11/12/5535}, year = {2021}, keywords = {selective retina therapy; viability assay; photocoagulation; microbubble formation; thermomechanical damage; fringe washout; coherence-loss}, type = {Journal Article} } |
Mario
Mordmüller,
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Karl
Worthmann,
Matthias A.
Müller, and
Ralf
Brinkmann,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Datei: | 12.2615851 |
Bibtex: | @inproceedings{Mordmüller2021, author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R}, title = { Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser}, booktitle = {ECBO}, url = {https://doi.org/10.1117/12.2615851}, year = {2021}, type = {Conference Proceedings} } |
Svenja
Sonntag,
Eric
Seifert,
Maximilian
Hamann,
Britta
Lewke,
Dirk
Theisen-Kunde,
Salvatore
Grisanti,
Ralf
Brinkmann, and
Yoko
Miura,
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
DOI: | https://www.mdpi.com/2075-1729/11/6/555 |
Datei: | 555 |
Bibtex: | @article{Miura2021-2, author = {Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y}, title = {Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States}, journal = {Life}, volume = {11(6)}, keywords = {retinal laser treatment; metabolic change; fluorescence lifetime imaging ophthalmoscopy}, pages = {555}, ISSN = {2075-1729}, url = {https://www.mdpi.com/2075-1729/11/6/555}, year = {2021}, type = {Journal Article} } |
E.
Seifert,
Kleingarn
Philipp,
Svenja
Sonntag,
Dirk
Theisen-Kunde,
Salvatore
Grisanti,
Reginald
Birngruber,
Yoko
Miura, and
Ralf
Brinkmann,
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
DOI: | 10.1167/iovs.62.3.32 |
Datei: | iovs.62.3.32 |
Bibtex: | @article{Seifert2021, author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R}, title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime}, journal = {Investigative Ophthalmology & Visual Science}, volume = {62(3)}, pages = {32-32}, ISSN = {1552-5783}, DOI = {10.1167/iovs.62.3.32}, url = {https://doi.org/10.1167/iovs.62.3.32}, year = {2021}, type = {Journal Article} } |
Dirk
Theisen-Kunde,
Wolfgang
Draxinger,
Matteo M.
Bonsanto,
Paul
Strenge,
Nicolas
Detrez,
Robert
Huber, and
Ralf
Brinkmann,
1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery, in European Conferences on Biomedical Optics 2021 (ECBO) , Optica Publishing Group, 2021. pp. ETu4A.2.
1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery, in European Conferences on Biomedical Optics 2021 (ECBO) , Optica Publishing Group, 2021. pp. ETu4A.2.
Weblink: | https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETu4A.2 |
Datei: | abstract.cfm |
Bibtex: | @inproceedings{Theisen-Kunde:21, author = {D. Theisen-Kunde and W. Draxinger and M. M. Bonsanto and Paul Strenge and Nicolas Detrez and R. Huber and R. Brinkmann}, booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {Clinical applications; Fourier domain mode locking; Optical coherence tomography; Optical fibers; Three dimensional reconstruction; White light}, pages = {ETu4A.2}, publisher = {Optica Publishing Group}, title = {1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery}, year = {2021}, url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETu4A.2}, doi = {10.1364/ECBO.2021.ETu4A.2}, abstract = {A 1.6 MHz Fourier-domain mode-locked (FDML) optical coherence tomography (OCT) was adapted to an OR-Microscope for clinical application in neurosurgery. 3D-volume scans at video rate are envisaged with approximately 50{\textmu}m lateral and 20{\textmu}m axial resolution.}, } |
Mario
Mordmüller,
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Dirk
Theisen-Kunde,
Karl
Worthmann,
Matthias A.
Müller, and
Ralf
Brinkmann,
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Datei: | aot-2021-0041 |
Bibtex: | @article{Mordmüller-2021, author = {Mordmüller, M;Kleyman, V;Schaller, M;Wilson, M;Theisen-Kunde, D;Worthmann, K;Müller, M.A and Brinkmann, R}, title = {Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate}, journal = {Advanced Optical Technologies}, Keywords = {extended Kalman filter; laser-coagulation; model predictive control; ophthalmology; photo-acoustics}, url = {https://doi.org/10.1515/aot-2021-0041}, year = {2021}, type = {Journal Article} } |
Maximilian
Büttner,
Benjamin
Luger,
Wasim Abou
Moulig,
Bernd
Junker,
Carsten
Framme,
Christina
Jacobson,
Katharina
Knoll,
Amelie
Pielen,
SRT Study Group-Theisen-Kunde, Brinkmann, Miura,Birngruber,
Ralf
Brinkmann,
Dirk
Theisen-Kunde, and
Yoko
Miura,
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
DOI: | 10.1007/s00417-020-04999-9 |
Bibtex: | @article{Büttner2021, author = {Büttner, M.;Luger, B.;Abou Moulig, W.;Junker, B.;Framme, C.;Jacobsen, C.;Knoll, K. and Pielen, A.; SRT Study Group(Brinkmann, R.; Miura, Y.)}, title = {Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {259}, number = {6}, pages = {1401-1410}, ISSN = {0721-832X (Print) 0721-832x}, DOI = {10.1007/s00417-020-04999-9}, abstract = { PURPOSE: Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% within 6 months. In this study, the efficacy of selective retina therapy (SRT) was examined in patients with therapy refractory persistent acute CSC defined by symptoms for at least 6 months and persistent subretinal fluid (SRF) despite eplerenone therapy. MATERIAL AND METHODS: This is a prospective, monocentric observational study in 17 eyes (16 patients, mean age 42 years, 2 female). SRT was performed with the approved R:GEN laser (Lutronic, South Korea), a micropulsed 527-nm Nd:YLF laser device, with a train of 30 pulses of 1.7 μs at 100-Hz repetition rate at the point of focal leakage determined by fluorescein angiography (FA) at baseline (BSL). Visits on BSL, week 4 (wk4), and week 12 (wk12) included best corrected visual acuity (BCVA, logMar), central retinal thickness (CRT) on spectral domain optical coherence tomography (SD-OCT), and FA. Statistical analysis was performed by pair-by-pair comparisons of multiple observations in each case with Bonferroni correction for multiple testing. (IBM SPSS Statistics 25®). RESULTS: Mean CRT at BSL was 387.69 ± 110.4 μm. CRT significantly decreased by 106.31 μm in wk4 (95%-KI: 21.42-191.2; p = 0.01), by 133.63 μm in wk12 (95%-KI: 50.22-217.03; p = 0.001) and by 133.81 μm (95%-KI: 48.88-218.75; p = 0.001) compared to BSL. Treatment success defined as complete resolution of SRF occurred at wk4 in 7/17 eyes (35.3%) and at wk12 in 10/17 eyes (58.8%). Re-SRT was performed in 7/17 eyes (41.2%) after an average of 107.14 ± 96.59 days. Treatment success after Re-SRT was observed in 4/6 eyes (66.6%, 12 weeks after Re-SRT). Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. Notably, eyes with treatment success showed better BCVA at all timepoints and gained more letters compared to failures. CONCLUSION: Single or repetitive SRT may be an effective and safe treatment in 2 of 3 patients suffering from acute persistent CSC after 6 months of symptoms or more. We observed complete resolution of SRF in around 60% of eyes 12 weeks after first SRT treatment and also 12 weeks after Re-SRT treatment in eyes with persistent or recurrent SRF. Results on the long-term course after SRT are still pending.}, keywords = { Central serous chorioretinopathy; Fluorescein angiography; Micropulse laser; OCT; Persistent acute disease; Selective retina treatment; Subretinal fluid. }, year = {2021}, type = {Journal Article} } |
Elisabeth
Richert,
Claus
von der Burchard,
Alexa
Klettner,
Patrik
Arnold,
Ralph
Lucius,
Ralf
Brinkmann,
Johann
Roider, and
Jan
Tode,
Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models, 09 2020.
Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models, 09 2020.
Datei: | S2590153220300112 |
Bibtex: | @article{RN5351, author = {Richert, E;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Roider, J and Tode, J}, title = {Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models}, journal = {Cytokine: X}, volume = {2}, number = {3}, pages = {100031}, ISSN = {2590-1532}, DOI = {https://doi.org/10.1016/j.cytox.2020.100031}, url = {https://www.sciencedirect.com/science/article/pii/S2590153220300112}, year = {2020}, type = {Journal Article} } |