Cuiping
Yao,
Florian
Rudnitzki,
Yida
He,
Zhenxi
Zhang,
Gereon
Hüttmann, and
Ramtin
Rahmanzadeh,
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
DOI: | 10.1002/jbio.202000017 |
Bibtex: | @article{Rahmanzadeh-2020, author = {Yao, C;Rudnitzki, F;He, Y;Zhang, Z;Hüttmann, G and Rahmanzadeh, R}, title = {Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods}, journal = {JBio}, ISSN = {1864-063X}, DOI = {10.1002/jbio.202000017}, Year = {2020}, type = {Journal Article} } |
Ramtin
Rahmanzadeh,
Florian
Rudnitzki, and
Gereon
Hüttmann,
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
DOI: | 10.1002/jbio.201800460 |
Datei: | jbio.201800460 |
Bibtex: | @article{Rahmanzadeh-2019, author = {Rahmanzadeh, R;Rudnitzki, F and Hüttmann, G}, title = {Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes}, journal = {Journal of Biophotonics}, Year = {2019}, pages = {e201800460}, ISSN = {1864-063X}, DOI = {10.1002/jbio.201800460}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201800460}, type = {Journal Article} } |
Cuiping
Yao,
Florian
Rudnitzki,
Gereon
Hüttmann,
Zhenxi
Zhang, and
Ramtin
Rahmanzadeh,
Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation, International Journal of Nanomedicine , vol. 12, pp. 5659-5672, 2017.
Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation, International Journal of Nanomedicine , vol. 12, pp. 5659-5672, 2017.
DOI: | 10.2147/IJN.S140620 |
Bibtex: | @article{Yao2017, author = {Yao, C; Rudnitzki, F; Hüttmann, G; Zhang, Zand Rahmanzadeh, R}, title = {Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation}, journal = {International Journal of Nanomedicine}, pages = {5659-5672}, DOI = {10.2147/IJN.S140620}, year = {2017}, type = {Journal Article} } |
Sijia
Wang,
Gereon
Hüttmann,
Florian
Rudnitzki,
Heyke
Diddens-Tschoeke,
Zhenxi
Zhang, and
Ramtin
Rahmanzadeh,
Indocyanine green as effective antibody conjugate for intracellular molecular targeted photodynamic therapy, Journal of Biomedical Optics , vol. 21, no. 7, pp. 078001-078001, 2016.
Indocyanine green as effective antibody conjugate for intracellular molecular targeted photodynamic therapy, Journal of Biomedical Optics , vol. 21, no. 7, pp. 078001-078001, 2016.
DOI: | 10.1117/1.JBO.21.7.078001 |
Bibtex: | @article{Wang2016, author = {Wang, Sijia and Hüttmann, Gereon and Rudnitzki, Florian and Diddens-Tschoeke, Heyke and Zhang, Zhenxi and Rahmanzadeh, Ramtin}, title = {Indocyanine green as effective antibody conjugate for intracellular molecular targeted photodynamic therapy}, journal = {Journal of Biomedical Optics}, volume = {21}, number = {7}, pages = {078001-078001}, note = {10.1117/1.JBO.21.7.078001}, abstract = {Abstract. The fluorescent dye indocyanine green (ICG) is clinically approved and has been applied for ophthalmic and intraoperative angiography, measurement of cardiac output and liver function, or as contrast agent in cancer surgery. Though ICG is known for its photochemical effects, it has played a minor role so far in photodynamic therapy or techniques for targeted protein-inactivation. Here, we investigated ICG as an antibody-conjugate for the selective inactivation of the protein Ki-67 in the nucleus of cells. Conjugates of the Ki-67 antibody TuBB-9 with different amounts of ICG were synthesized and delivered into HeLa and OVCAR-5 cells through conjugation to the nuclear localization sequence. Endosomal escape of the macromolecular antibodies into the cytoplasm was optically triggered by photochemical internalization with the photosensitizer BPD. The second light irradiation at 690 nm inactivated Ki-67 and subsequently caused cell death. Here, we show that ICG as an antibody-conjugate can be an effective photosensitizing agent. Best effects were achieved with 1.8 ICG molecules per antibody. Conjugated to antibodies, the ICG absorption peaks vary proportionally with concentration. The absorption of ICG above 650 nm within the optical window of tissue opens the possibility of selective Ki-67 inactivation deep inside of tissues.}, ISSN = {1083-3668}, year = {2016}, type = {Journal Article} } |
Florian
Rudnitzki,
Marco
Bever,
Ramtin
Rahmanzadeh,
Katrin
Brieger,
Elmar
Endl, and
Jürgen
Groll,
Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction, J Biomed Opt , vol. 17, no. 5, pp. 058003, 2012.
Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction, J Biomed Opt , vol. 17, no. 5, pp. 058003, 2012.
DOI: | 10.1117/1.JBO.17.5.058003 |
Bibtex: | @Article{pmid22612150, Author="Rudnitzki, F. and Bever, M. and Rahmanzadeh, R. and Brieger, K. and Endl, E. and Groll, J. and Huttmann, G. ", Title="{{B}leaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction}", Journal="J Biomed Opt", Year="2012", Volume="17", Number="5", Pages="058003", Month="May" } |
Ramtin
Rahmanzadeh,
Florian
Rudnitzki,
Elmar
Endl, and
Tayyaba
Hasan,
Targeted molecular effects through laser-irradiated nanoabsorbers, in Proc. SPIE , Newsrrom, SPIE, Eds. 2011.
Targeted molecular effects through laser-irradiated nanoabsorbers, in Proc. SPIE , Newsrrom, SPIE, Eds. 2011.
DOI: | 10.1117/2.1201102.003548 |
Bibtex: | @inproceedings{Hüttmann2011, author = {Hüttmann, Gereon and Rahmanzadeh, Ramtin and Rudnitzki, Florian and Endl, Elmar and Hasan, Tayyaba}, title = {Targeted molecular effects through laser-irradiated nanoabsorbers}, editor = {Newsrrom, SPIE}, DOI = {10.1117/2.1201102.003548}, type = {Conference Proceedings}, year = { 2011} } |