


2023
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christian
Hagel,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321P.
Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321P.
DOI: | 10.1117/12.2670907 |
File: | 12.2670907 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670907, author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann}, title = {{Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}}, volume = {12632}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V}, editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126321P}, keywords = {Brain Tumor, OCT, Optical Coherence Tomography, Prior Network, Glioblastoma Multiforme, Neural Network, Classification}, year = {2023}, doi = {10.1117/12.2670907}, URL = {https://doi.org/10.1117/12.2670907} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christian
Hagel,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 1236805.
Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 1236805.
DOI: | 10.1117/12.2649963 |
Bibtex: | ![]() @inproceedings{10.1117/12.2649963, author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann}, title = {{Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography}}, volume = {12368}, booktitle = {Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI}, editor = {Caroline Boudoux and James W. Tunnell}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236805}, abstract = {The ill-defined tumor borders of glioblastoma multiforme pose a major challenge for the surgeon during tumor resection, since the goal of the tumor resection is the complete removal, while saving as much healthy brain tissue as possible. In recent years, optical coherence tomography (OCT) was successfully used to classify white matter from tumor infiltrated white matter by several research groups. Motivated by these results, a dataset was created, which consisted of sets of corresponding ex vivo OCT images, which were acquired by two OCT-systems with different properties (e.g. wavelength and resolution). Each image was annotated with semantic labels. The labels differentiate between white and gray matter and three different stages of tumor infiltration. The data from both systems not only allowed a comparison of the ability of a system to identify the different tissue types present during the tumor resection, but also enable a multimodal tissue analysis evaluating corresponding OCT images of the two systems simultaneously. A convolutional neural network with dirichlet prior was trained, which allowed to capture the uncertainty of a prediction. The approach increased the sensitivity of identifying tumor infiltration from 58 % to 78 % for data with a low prediction uncertainty compared to a previous monomodal approach. }, keywords = {optical coherence tomography, oct, brain, classification, tumor, dual wavelength, glioblastoma multiforme, tissue analysis}, year = {2023}, doi = {10.1117/12.2649963}, URL = {https://doi.org/10.1117/12.2649963} } |
Christin
Grill,
Julie-Jacqueline
Kuhl,
Maximiliane Amelie
Schlenz, and
Ralf
Brinkmann,
Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 2023. pp. 126320J.
Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 2023. pp. 126320J.
DOI: | 10.1117/12.2670874 |
File: | 12.2670874 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670874, author = {Christin Grill and Julie-Jacqueline Kuhl and Maximiliane Amelie Schlenz and Ralf Brinkmann}, title = {{Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography}}, volume = {12632}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V}, editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126320J}, keywords = {Optical Coherence Tomography, OCT, Monolithic dental crowns, CAD/CAM materials, Microcracks, Non-destructive method, Fatigue damage, Dental materials}, year = {2023}, doi = {10.1117/12.2670874}, URL = {https://doi.org/10.1117/12.2670874} } |
2022
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Christian
Hagel,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Heinz
Handels,
Ralf
Brinkmann, and
Robert
Huber,
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
DOI: | 10.3389/fonc.2022.896060 |
Bibtex: | ![]() @article{Strenge-2022, author = {Strenge, P.;Lange, B.;Grill,C.;Danicke,V.;Theisen-Kunde, D.;Hagel, C.;Spahr-Hess, S.;;Bonsanto, Matteo M.;Handels, H.; and Huber, R.;Brinkmann, R.}, title = {Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology}, journal = {Frontiers in Oncology}, Keywords = {AG-Huber_FDML, AG-Huber_OCT, brain, tumor, glioblastoma multiforme, OCT, neural network, attenuation (absorption) coefficient, optical coherence tomography}, DOI = {https://doi.org/10.3389/fonc.2022.896060}, url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.896060/full}, year = {2022}, type = {Journal Article} } |
Christin
Grill,
Torben
Blömker,
Mark
Schmidt,
Dominic
Kastner,
Tom
Pfeiffer,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Sebastian
Karpf,
Christian
Jirauschek, and
Robert
Huber,
Towards phase-stabilized Fourier domain mode-locked frequency combs, Communications Physics , vol. 5, no. 1, 08 2022. Springer Science and Business Media LLC.
Towards phase-stabilized Fourier domain mode-locked frequency combs, Communications Physics , vol. 5, no. 1, 08 2022. Springer Science and Business Media LLC.
DOI: | 10.1038/s42005-022-00960-w |
Bibtex: | ![]() @article{Grill2022, doi = {10.1038/s42005-022-00960-w}, year = {2022}, publisher = {Springer Science and Business Media {LLC}}, volume = {{5}}, number = {{1}}, author = {C. Grill, T. Bl\"{o}mker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber}, title = {Towards phase-stabilized Fourier domain mode-locked frequency combs}, journal = {{Communications Physics}}, keywords={AG-Huber_FDML, FDML, Fourier domain mode locking, phase, frequency comb, coherence, beating} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Christian
Hagel,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
DOI: | 10.1088/1361-6560/ac6d9d |
Bibtex: | ![]() @article{Strenge2022, author = {Strenge, P;Lange, B;Grill, C;Draxinger, W;Danicke, V;Theisen-Kunde, D;Hagel, C;Spahr-Hess, S;Bonsanto, Matteo M.;Huber, R;Handels, H and Brinkmann, R}, title = {Registration of histological brain images onto optical coherence tomography images based on shape information}, keywords = {brain, glioblastoma multiforme, shape, OCT, optical coherence tomography, AG-Huber_OCT,}, journal = {Physics in Medicine & Biology}, ISSN = {0031-9155}, url = {http://iopscience.iop.org/article/10.1088/1361-6560/ac6d9d}, year = {2022}, type = {Journal Article} } |
2021
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dec.2021. pp. EW1C.7.
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dec.2021. pp. EW1C.7.
DOI: | 10.1117/12.2616044 |
Bibtex: | ![]() @inproceedings{Strenge:21, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography}, pages = {EW1C.7}, publisher = {Optical Society of America}, title = {Comparison of two optical coherence tomography systems to identify human brain tumor}, year = {2021}, url = {https://doi.org/10.1117/12.2616044}, abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.}, } |
Christin
Grill,
Simon
Lotz,
Torben
Blömker,
Mark
Schmidt,
Wolfgang
Draxinger,
Jan Philip
Kolb,
Christian
Jirauschek, and
Robert
Huber,
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
DOI: | 10.1109/CLEO/Europe-EQEC52157.2021.9542126 |
Bibtex: | ![]() @INPROCEEDINGS{9542126, author={Grill, Christin and Lotz, Simon and Blömker, Torben and Schmidt, Mark and Draxinger, Wolfgang and Kolb, Jan Philip and Jirauschek, Christian and Huber, Robert}, booktitle={2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={Superposition of two independent FDML lasers}, year={2021}, volume={}, number={}, pages={1-1}, abstract={Fourier domain mode locking (FDML) is a laser operating regime, which was developed in 2005 [1] . The output of this laser is a train of optical wavelength sweeps, equivalent to extremely chirped pulses with an optical bandwidth of up to 25 THz and frequency tuning rates of >10 19 Hz/s. This laser type was developed for optical coherence tomography [2] , but found recently more and more applications like LiDAR [3] , Raman microscopy [4] or two-photon microscopy [5] . The laser’s coherence properties are relevant for a better understanding of the FDML laser itself and its applications. Because of the wide sweep range and high tuning rate, the laser linewidth cannot be measured with an RF spectrometer. Superposition with a narrowband continuous wave laser only yields phase information for small fractions of the sweep [6] . However, beat signal measurements between two independent FDML lasers with equal sweep range and direction can give information about the complete sweep.}, keywords={}, doi={10.1109/CLEO/Europe-EQEC52157.2021.9542126}, ISSN={}, month={June} } |
Tom
Pfeiffer,
Thomas
Klein,
Alexander
Mlynek,
Wolfgang
Wieser,
Simon
Lotz,
Christin
Grill, and
Robert
Huber,
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
DOI: | 10.1117/12.2583501 |
Bibtex: | ![]() @inproceedings{Pfeiffer2021, author = {T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill and R. Huber}, title = {{High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, abstract = {We demonstrate that the coherence roll-off and dynamic range of OCT systems using Fourier-domain mode-locked (FDML) lasers can be significantly improved by a fiber Fabry-Perot tunable filter (FFP-TF) with a finesse of more than 3000, a more than fivefold improvement over previous designs. In contrast to previous work, standard resampling using a pre-acquired signal (as in SD-OCT) with no k-clocking is sufficient for 20 nm and 100 nm sweep range, significantly reducing the system complexity. 3D-OCT imaging at 20 cm imaging range is demonstrated.}, keywords = {AG-Huber_FDML, AG-Huber_OCT, optical coherence tomography, FDML laser, swept source laser, high finesse, Fabry-Perot, MHz-OCT, OCT, tunable laser}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2583501} } |
Christin
Grill,
Torben
Blömker,
Mark
Schmidt,
Dominic
Kastner,
Tom
Pfeiffer,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Sebastian
Karpf,
Christian
Jirauschek, and
Robert
Huber,
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
DOI: | 10.1117/12.2578293 |
Bibtex: | ![]() @inproceedings{Grill2021, author = {C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber}, title = {{A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements}}, volume = {11665}, booktitle = {Fiber Lasers XVIII: Technology and Systems}, editor = {Michalis N. Zervas}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {242 -- 247}, keywords = {AG-Huber_FDML, Fourier domain mode locking, FDML laser, laser beating , tunable laser, optical coherence tomography, OCT}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578293} } |
Simon
Lotz,
Christin
Grill,
Madita
Göb,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
DOI: | 10.1364/BOE.422898 |
Bibtex: | ![]() @article{Lotz2021, author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber}, title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision}, journal = {Biomedical Optics Express}, volume = {12(5)}, keywords={AG-Huber_FDML}, pages = {2604-2616}, url = {https://doi.org/10.1364/BOE.422898}, year = {2021}, type = {Journal Article} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Christian
Hagel,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
DOI: | 10.1117/12.2578391 |
Bibtex: | ![]() @inproceedings{Strenge2021, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann}, title = {{Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {66 -- 73}, abstract = {Optical coherence tomography (OCT) has the potential to become an additional imaging modality for surgical guidance in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. Interpretation of the images, however, is still a big challenge. A method to create a labeled OCT dataset based on ex vivo brain samples is introduced. The tissue samples were embedded in an agarose mold giving them a distinctive shape before images were acquired with two OCT systems (spectral domain (SD) and swept source (SS) OCT) and histological sections were created and segmented by a neuropathologist. Based on the given shape, the corresponding OCT images for each histological image can be determined. The transfer of the labels from the histological images onto the OCT images was done with a non-affine image registration approach based on the tissue shape. It was demonstrated that finding OCT images of a tissue sample corresponding to segmented histological images without any color or laser marking is possible. It was also shown that the set labels can be transferred onto OCT images. The accuracy of method is 26 ± 11 pixel, which translates to 192 ± 75 μm for the SS-OCT and 94 ± 43 μm for the SD-OCT. The dataset consists of several hundred labeled OCT images, which can be used to train a classification algorithm.}, keywords = {AG-Huber_OCT, optical coherence tomography, OCT, image registration, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery}, year = {2021}, URL = {https://doi.org/10.1117/12.2578391} } |
Mark
Schmidt,
Christin
Grill,
Simon
Lotz,
Tom
Pfeiffer,
Robert
Huber, and
Christian
Jirauschek,
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
DOI: | 10.1007/s00340-021-07600-1 |
Bibtex: | ![]() @Article{Schmidt2021, author = {M. Schmidt, C. Grill, S. Lotz, T. Pfeiffer, R. Hubert and C. Jirauschek}, journal = {Applied Physics B}, title = {Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime}, year = {2021}, issn = {1432-0649}, number = {5}, pages = {60}, volume = {127}, keywords={AG-Huber_FDML}, abstract = {We report on the formation of various intensity pattern types in detuned Fourier domain mode-locked (FDML) lasers and identify the corresponding operating conditions. Such patterns are a result of the complex laser dynamics and serve as an ideal tool for the study of the underlying physical processes as well as for model verification. By numerical simulation we deduce that the formation of patterns is related to the spectral position of the instantaneous laser lineshape with respect to the transmission window of the swept bandpass filter. The spectral properties of the lineshape are determined by a long-term accumulation of phase-offsets, resulting in rapid high-amplitude intensity fluctuations in the time domain due to the narrow intra-cavity bandpass filter and the fast response time of the semiconductor optical amplifier gain medium. Furthermore, we present the distribution of the duration of dips in the intensity trace by running the laser in the regime in which dominantly dips form, and give insight into their evolution over a large number of roundtrips.}, doi = {10.1007/s00340-021-07600-1}, refid = {Schmidt2021}, } |
Simon
Lotz,
Christin
Grill,
Madita
Göb,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
DOI: | 10.1117/12.2578514 |
Bibtex: | ![]() @inproceedings{LotzLASE2021, author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber}, title = {{Characterization of the dynamics of an FDML laser during closed-loop cavity length control}}, volume = {11665}, booktitle = {Fiber Lasers XVIII: Technology and Systems}, editor = {Michalis N. Zervas}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {236 -- 241}, abstract = {In Fourier domain mode locked (FDML) lasers, extremely precise and stable matching of the filter tuning period and light circulation time in the cavity is essential for ultra-low noise operation. During the operation of FDML lasers, the ultra-low noise mode can be lost due to temperature drifts of the already temperature stabilized cavity resulting in increased intensity noise. Until now, the filter frequency is continuously regulated to match the changing light circulation time. However, this causes the filter frequency to constantly change by a few mHz and leads to synchronization issues in cases where a fixed filter frequency is desired. We present an actively cavity length controlled FDML laser and a robust and high precision feedback loop algorithm for maintaining ultra-low noise operation. Instead of adapting the filter frequency, the cavity length is adjusted by a motorized free space beam path to match the fixed filter frequency. The closed-loop system achieves a stability of ~0.18 mHz at a sweep repetition rate of ~418 kHz which corresponds to a ratio of 4×10<sup>-10</sup>. We investigate the coherence properties during the active cavity length adjustments and observe no noise increase compared to fixed cavity length. The cavity length control is fully functional and for the first time, offers the possibility to operate an FDML laser in sweet spot mode at a fixed frequency or phase locked to an external clock. This opens new possibilities for system integration of FDML lasers.}, keywords = {AG-Huber_FDML, FDML, Fourier domain mode locking, laser beating, tunable laser, optical coherence tomography, OCT}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578514} } |
2020
Mark
Schmidt,
Christin
Grill,
Robert
Huber, and
Christian
Jirauschek,
Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime, in 2020 International Conference Laser Optics (ICLO) , Nov.2020. pp. 1-1.
Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime, in 2020 International Conference Laser Optics (ICLO) , Nov.2020. pp. 1-1.
DOI: | 10.1109/ICLO48556.2020.9285488 |
Bibtex: | ![]() @INPROCEEDINGS{Schmidt2020ICLO, author={M. {Schmidt}, C. {Grill}, R. {Huber} and C. {Jirauschek}}, booktitle={2020 International Conference Laser Optics (ICLO)}, title={Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime}, year={2020}, keywords={AG-Huber_FDML}, volume={}, number={}, pages={1-1}, doi={10.1109/ICLO48556.2020.9285488}, } |
Mark
Schmidt,
Tom
Pfeiffer,
Christin
Grill,
Robert
Huber, and
Christian
Jirauschek,
Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2020. Optical Society of America.
Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2020. Optical Society of America.
DOI: | 10.1364/OSAC.389972 |
Bibtex: | ![]() @article{schmidt2020self, title={Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers}, author={M. {Schmidt}, T. {Pfeiffer}, C. {Grill}, R. {Huber} and C. {Jirauschek}}, journal={OSA Continuum}, volume={3}, number={6}, pages={1589--1607}, year={2020}, keywords={AG-Huber_FDML}, url={https://doi.org/10.1364/OSAC.389972}, publisher= {Optical Society of America} } |
Christin
Grill,
Simon
Lotz,
Torben
Blömker,
Dominic
Kastner,
Tom
Pfeiffer,
Mark
Schmidt,
Wolfgang
Draxinger,
Christian
Jirauschek, and
Robert
Huber,
Beating of two FDML lasers in real time, in Fiber Lasers XVII: Technology and Systems , Liang Dong, Eds. SPIE, 022020. pp. 132 -- 138.
Beating of two FDML lasers in real time, in Fiber Lasers XVII: Technology and Systems , Liang Dong, Eds. SPIE, 022020. pp. 132 -- 138.
DOI: | 10.1117/12.2545794 |
Bibtex: | ![]() @inproceedings{Grill2020, author = {C. {Grill}, S. {Lotz}, T. {Blömker}, D. {Kastner}, T. {Pfeiffer}, S. {Karpf}, M. {Schmidt}, W. {Draxinger}, C. {Jirauschek} and R. {Huber}}, title = {{Beating of two FDML lasers in real time}}, volume = {11260}, booktitle = {Fiber Lasers XVII: Technology and Systems}, editor = {Liang Dong}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {132 -- 138}, keywords = {AG-Huber_FDML, FDML laser, fiber lasers, beat signal, OCT, Optical Coherence Tomography, Fourier domain mode locking}, year = {2020}, doi = {10.1117/12.2545794}, } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV , SPIE, 022020. pp. 82 -- 89.
Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV , SPIE, 022020. pp. 82 -- 89.
DOI: | 10.1117/12.2545659 |
Bibtex: | ![]() @inproceedings{Strenge2020, author = {P. Strenge and B. Lange and C. Grill and W. Draxinger and M. M. Bonsanto and C. Hagel and R. Huber and R. Brinkmann}, title = {{Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis}}, volume = {11228}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {82 -- 89}, keywords = {AG-Huber_OCT, Optical coherence tomography, OCT, FDML Laser, MHz-OCT, brain tumor, brain imaging, neurosurgery}, year = {2020}, URL = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11228/112282O/Segmented-OCT-data-set-for-depth-resolved-brain-tumor-detection/10.1117/12.2545659.short} } |
2019
Yoko
Miura,
Wolfgang
Draxinger,
Christin
Grill,
Tom
Pfeiffer,
Salvatore
Grisanti, and
Robert
Huber,
MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. SPIE, 072019. pp. 110780E.
MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. SPIE, 072019. pp. 110780E.
DOI: | 10.1117/12.2527123 |
Bibtex: | ![]() @inproceedings{10.1117/12.2527123, author = {Yoko Miura and Wolfgang Draxinger and Christin Grill and Tom Pfeiffer and Salvatore Grisanti and Robert Huber}, title = {{MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye }}, volume = {11078}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III}, editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {110780E}, abstract = {MHz-OCT systems based on FDML swept laser sources combined with the massive parallel processing capabilities of modern computer hardware enable volumetric imaging, processing and stereoscopic display at video rates. The increasing image quality and speed might enable new fields of application where the volumetric OCT completely replaces stereoscopic microscopes instead of being a mere supplement. Aside from the depth resolving capability, a particular advantage is the ability to display a whole image volume from arbitrary points of view without the need to move the actual microscope or to rotate the patient’s eye. Purely digital microscopy is already offered as alternative to traditional through-an-eyepiece surgical microscope. We explore the use of virtual reality to present digital OCT microscopy images to a trained surgeon, carrying out a series of surgical procedures ex-vivo on a porcine eye model.}, keywords = {virtual reality, surgery guidance , real-time OCT, user experience}, year = {2019}, doi = {10.1117/12.2527123}, URL = {https://doi.org/10.1117/12.2527123} } |
Julian
Klee,
Jan Philip
Kolb,
Christin
Grill,
Wolfgang
Draxinger,
Tom
Pfeiffer, and
Robert
Huber,
Zero roll-off retinal MHz-OCT using an FDML-laser, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , SPIE, 072019. pp. 110780S.
Zero roll-off retinal MHz-OCT using an FDML-laser, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , SPIE, 072019. pp. 110780S.
DOI: | 10.1117/12.2527034 |
File: | 12.2527034.short |
Bibtex: | ![]() @inproceedings{10.1117/12.2527034, author = {Julian Klee and Jan Philip Kolb and Christin Grill and Wolfgang Draxinger and Tom Pfeiffer and Robert Huber}, title = {{Zero roll-off retinal MHz-OCT using an FDML-laser}}, volume = {11078}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III}, editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {110780S}, abstract = {Optical coherence tomography (OCT) applications like ultra-widefield and full eye-length imaging are of high interest for various diagnostic purposes. In swept-source OCT these techniques require a swept light source, which is coherent over the whole imaging depth. We present a zero roll-off 1060 nm Fourier Domain Mode Locked-Laser (FDML-Laser) for retinal OCT imaging at 1.7 MHz A-scan rate and first long-range imaging results with it. Several steps such as improved dispersion compensation and frequency regulation were performed and will be discussed. Besides virtually no loss in OCT signal over the maximum depth range of 4.6 mm and very good dynamic range was observed. Roll-off measurements show no decrease of the point-spread function (PSF), while maintaining a high dynamic range.}, keywords = {optical coherence tomography, OCT, tunable laser, Fourier Domain Mode Locking, FDML, MHz OCT}, year = {2019}, doi = {10.1117/12.2527034}, URL = {https://doi.org/10.1117/12.2527034} } |
Mark
Schmidt,
Tom
Pfeiffer,
Christin
Grill,
Robert
Huber, and
Christian
Jirauschek,
Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 2019. pp. 1--1.
Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 2019. pp. 1--1.
DOI: | 10.1109/CLEOE-EQEC.2019.8872381 |
Bibtex: | ![]() @inproceedings{schmidt2019coexistence, title={Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers}, author={Schmidt, M; Pfeiffer, T; Grill, C; Huber, R and Jirauschek, C}, booktitle={2019 Conference on Lasers and Electro-Optics Europe \& European Quantum Electronics Conference (CLEO/Europe-EQEC)}, pages={1--1}, year={2019}, organization={IEEE}, keywords= { AG-Huber_FDML}, url={ https://ieeexplore.ieee.org/document/8872381} } |
Dominic
Kastner,
Torben
Blömker,
Tom
Pfeiffer,
Christin
Grill,
Mark
Schmidt,
Christian
Jirauschek, and
Robert
Huber,
Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser, in 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference , Optical Society of America, 2019. pp. 1-1.
Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser, in 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference , Optical Society of America, 2019. pp. 1-1.
DOI: | 10.1109/CLEOE-EQEC.2019.8872860 |
Bibtex: | ![]() @inproceedings{Kastner:19, author = {Kastner, D; Bl\"{o}mker, T; Pfeiffer, T; Grill, C; Schmidt, M; Jirauschek, C and Huber, R}, booktitle = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference}, journal = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference}, keywords = {Fourier domain mode locking; Image quality; Optical coherence tomography; Phase noise; Ring lasers; Tunable lasers}, pages = {cj_7_5}, publisher = {Optical Society of America}, title = {Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser}, year = {2019}, keywords = {AG-Huber_FDML, AG-Huber_OCT}, doi = { 10.1109/CLEOE-EQEC.2019.8872860}, abstract = {Fourier Domain Mode Locking (FDML) lasers are light sources that generate a sequence of narrowband optical frequency sweeps at the fundamental or harmonic of the cavity repetition rate \[1\]. This frequency swept output can also be considered as a sequence of strongly chirped, long pulses. FDML lasers are mainly used in swept source optical coherence tomography (SS-OCT), a medical imaging technique. The coherence length of the source, i.e. the intra-sweep phase stability of an FDML sweep, is decisive for the image quality and performance of OCT imaging \[2\].}, } |
2018
Mark
Schmidt,
Tom
Pfeiffer,
Christin
Grill,
Robert
Huber, and
Christian
Jirauschek,
Self-Stabilization Mechanism in Fourier Domain Mode-Locked (FDML) Lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2018. Optica Publishing Group.
Self-Stabilization Mechanism in Fourier Domain Mode-Locked (FDML) Lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2018. Optica Publishing Group.
DOI: | 10.1364/OSAC.389972 |
Bibtex: | ![]() @article{Schmidt:20, author = {Mark Schmidt and Tom Pfeiffer and Christin Grill and Robert Huber and Christian Jirauschek}, journal = {OSA Continuum}, keywords = {Doppler effect; Laser modes; Laser sources; Nonlinear effects; Stimulated Raman scattering; Vertical cavity surface emitting lasers}, number = {6}, pages = {1589--1607}, publisher = {Optica Publishing Group}, title = {Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers}, volume = {3}, month = {Jun}, year = {2020}, url = {https://opg.optica.org/osac/abstract.cfm?URI=osac-3-6-1589}, doi = {10.1364/OSAC.389972}, abstract = {Understanding the dynamics of Fourier domain mode-locked (FDML) lasers is crucial for determining physical coherence limits, and for finding new superior methods for experimental realization. In addition, the rich interplay of linear and nonlinear effects in a laser ring system is of great theoretical interest. Here we investigate the dynamics of a highly dispersion-compensated setup, where over a bandwidth of more than 100\&\#x2009;nm, a highly coherent output with nearly shot-noise-limited intensity fluctuations was experimentally demonstrated. This output is called the sweet-spot. We show by numerical simulation that a finite amount of residual dispersion in the fiber delay cavity of FDML lasers can be compensated by the group delay dispersion in the swept bandpass filter, such that the intensity trace exhibits no dips or high-frequency distortions, which are the main source of noise in the laser. In the same way, a small detuning from the ideal sweep filter frequency can be tolerated. Furthermore, we find that the filter\&\#x2019;s group delay dispersion improves the coherence properties of the laser, and acts as a self-stabilizing element in the cavity. Our theoretical model is validated against experimental data, showing that all relevant physical effects for the sweet-spot operating regime are included.}, } |
2017
Tom
Pfeiffer,
Wolfgang
Draxinger,
Christin
Grill, and
Robert
Huber,
Long-range live 3D-OCT at different spectral zoom levels, in Optical Coherence Imaging Techniques and Imaging in Scattering Media II , Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. SPIE, 082017. pp. 104160L.
Long-range live 3D-OCT at different spectral zoom levels, in Optical Coherence Imaging Techniques and Imaging in Scattering Media II , Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. SPIE, 082017. pp. 104160L.
DOI: | 10.1117/12.2287484 |
Bibtex: | ![]() @inproceedings{10.1117/12.2287484, author = {Tom Pfeiffer and Wolfgang Draxinger and Christin Grill and Robert Huber}, title = {{Long-range live 3D-OCT at different spectral zoom levels}}, volume = {10416}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media II}, editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {104160L}, abstract = {We demonstrate that the 3.2 MHz a-scan rate and the improved coherence of our new low noise FDML laser enables live 3D-OCT with different spectral zooms and up to 10 cm of imaging range.}, keywords = {Optical coherence tomography, Fourier Domain Mode Locking, FDML, OCT}, year = {2017}, doi = {10.1117/12.2287484}, URL = {https://doi.org/10.1117/12.2287484} } |