2003
S.
Teschner,
J.
Noack, and
U.
Schmidt-Erfurth,
Characterization of leakage activity in exudative chorioretinal disease with three-dimensional confocal angiography, Ophthalmology , vol. 110, no. 4, pp. 687-697, 2003.
Characterization of leakage activity in exudative chorioretinal disease with three-dimensional confocal angiography, Ophthalmology , vol. 110, no. 4, pp. 687-697, 2003.
DOI: | Doi 10.1016/S6420(02)01972-3 |
File: | WOS:000182566600026 |
Bibtex: | @article{Teschner2003, author = {Teschner, S. and Noack, J. and Birngruber, R. and Schmidt-Erfurth, U.}, title = {Characterization of leakage activity in exudative chorioretinal disease with three-dimensional confocal angiography}, journal = {Ophthalmology}, volume = {110}, number = {4}, pages = {687-697}, note = {673EE Times Cited:8 Cited References Count:30}, abstract = {Purpose: A novel angiographic technique providing topographic imaging of chorioretinal fluorescence is applied to the characterization of leakage dynamics in exudative chorioretinopathy. The three-dimensional imaging is evaluated with respect to results with conventional two-dimensional fluorescence angiography. Design: Prospective observational case series. Participants: Thirty eyes of 30 patients with different exudative maculopathies (pigment epithelium detachment, branch retinal vein occlusion, central serous chorioretinopathy, each n = 10) and 11 eyes of 10 patients with clinically normal appearance. Methods: Depth-resolved fluorescence angiography using a confocal scanning laser system was performed after complete ophthalmologic examination. The axial distribution of fluorescein and indocyanine green fluorescence at each x/y position within a tomographic scan of 32 images was analyzed. The chorioretinal fluorescence topography was reconstructed by localizing a defined threshold value of fluorescence and displayed as topographic relief. Qualitative description and quantitative measurements of exudation or structural alterations were performed topographically and conventionally. Main Outcome Measures. Qualitative and quantitative analysis of structural or exudative changes in time course in topographic illustration compared with conventional angiography. Results: Clinically physiologic eyes were presented topographically as a smooth concave surface of fluorescence with defined illustration of retinal vascular structures and the optic disc. Retinal vascular pathologic conditions induce a precisely demarcated pattern of intraretinal edema with a characteristic temporal evolution. In central serous retinopathy the underlying pathologic condition was identified as a perfusion defect, which was subsequently filled with a peak of exudation with differences in the time of maximum in fluorescein/indocyanine green angiography. Pigment epithelium detachment appeared as a high and well defined elevation, with the origin of exudation within the base of the detachment. Differences in the time of maximum prominence were found in indocyanine green angiography within the pigment epithelium detachment group. Conclusions: Confocal topographic angiography allows for the first time precise three-dimensional functional imaging of fundus alterations caused by leakage or barrier dysfunction. Compared with conventional angiography, depth-resolved angiographic imaging is less impaired by masking phenomena or low fluorescence intensity, which improves the diagnostic yield of angiography. The characterization and quantification of leakage activity is a promising tool in the assessment of exudative maculopathy. (C) 2003 by the American Academy of Ophthalmology.}, keywords = {indocyanine green angiography scanning laser ophthalmoscope central serous chorioretinopathy choroidal neovascularization macular degeneration topographic angiography retinal thickness fluorescein videoangiography tomography}, ISSN = {0161-6420}, DOI = {Doi 10.1016/S6420(02)01972-3}, url = {<Go to ISI>://WOS:000182566600026}, year = {2003}, type = {Journal Article} } |
N.
Koop,
M.
Ozdemir,
C.
Alt,
G.
Schule, and
C. P.
Lin,
Targeting of the retinal pigment epithelium (RPE) by means of a rapidly scanned continuous wave (CW) laser beam, Lasers Surg Med , vol. 32(4), pp. 252-64, 2003.
Targeting of the retinal pigment epithelium (RPE) by means of a rapidly scanned continuous wave (CW) laser beam, Lasers Surg Med , vol. 32(4), pp. 252-64, 2003.
File: | lsm.10150 |
Bibtex: | @article{Brinkmann2003, author = {Brinkmann, R. and Koop, N. and Ozdemir, M. and Alt, C. and Schule, G. and Lin, C. P. and Birngruber, R.}, title = {Targeting of the retinal pigment epithelium (RPE) by means of a rapidly scanned continuous wave (CW) laser beam}, journal = {Lasers Surg Med}, volume = {32(4)}, year = { 2003}, url = { https://onlinelibrary.wiley.com/doi/abs/10.1002/lsm.10150}, pages = {252-64}, note = {0196-8092 (Print)} } |
Yoko
Miura,
Nubuyo
Yanagihara,
Hitoshi
Imamura,
Mayumi
Kaida,
Mitsuyasu
Moriwaki,
Kunihiko
Shiraki, and
Tokuhiko
Miki,
Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro, Jpn J Ophthalmol , vol. 47, no. 3, pp. 268-75, 2003.
Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro, Jpn J Ophthalmol , vol. 47, no. 3, pp. 268-75, 2003.
DOI: | 10.1016/s0021-5155(03)00003-0 |
Bibtex: | @article{Miura2003, author = {Miura, Y. and Yanagihara, N. and Imamura, H. and Kaida, M. and Moriwaki, M. and Shiraki, K. and Miki, T.}, title = {Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro}, journal = {Jpn J Ophthalmol}, volume = {47}, number = {3}, pages = {268-75}, note = {Miura, Yoko Yanagihara, Nobuyo Imamura, Hitoshi Kaida, Mayumi Moriwaki, Mitsuyasu Shiraki, Kunihiko Miki, Tokuhiko eng Research Support, Non-U.S. Gov't 2003/06/05 05:00 Jpn J Ophthalmol. 2003 May-Jun;47(3):268-75.}, abstract = {PURPOSE: A defect in retinal pigment epithelial (RPE) cells may cause dysfunction of the neural retina, so rapid recovery of differentiated RPE cells is required after RPE injury. We investigated the effect of hepatocyte growth factor (HGF) on wound healing in RPE cells. METHODS: Confluent monolayers of bovine RPE cells were denuded, and the cells were allowed to recover in the presence or absence of HGF. The effect of HGF on RPE cell proliferation was evaluated by a 3-(4;5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tet raz olium assay. In a migration assay, mitomycin C was used to inhibit proliferation, and the number of migrated cells was counted. The signaling pathways involved were examined using inhibitors of mitogen-activated protein kinase (MAPK), phosphatidylinositol-3 (PI3) kinase and protein kinase C pathways. RESULTS: At 80 ng/mL, HGF stimulated the wound closure of RPE monolayers and rendered the restituted cells more epithelioid in shape. HGF at 10 ng/mL stimulated RPE cell migration the most, whereas 80 ng/mL of HGF inhibited migration, but stimulated proliferation the most. In particular, PI3 kinase and MAPK inhibitor inhibited PRE cell migration and proliferation, respectively. CONCLUSIONS: HGF stimulated wound closure in cultured RPE cells, and rendered restituted cells epithelioid in shape. HGF may become a therapeutic candidate for RPE wound healing.}, keywords = {Animals Cattle Cell Count Cell Division/*drug effects Cell Movement/*drug effects Cells, Cultured Enzyme Inhibitors/pharmacology Hepatocyte Growth Factor/*pharmacology Mitogen-Activated Protein Kinases/antagonists & inhibitors Phosphatidylinositol 3-Kinases/antagonists & inhibitors Pigment Epithelium of Eye/*cytology/physiology Protein Kinase C/antagonists & inhibitors Signal Transduction Wound Healing/*drug effects}, year = {2003} } |
H.
Hoerauf,
A.
Brix,
C.
Scholz,
J.
Winkler,
G.
Dröge,
Alfred
Vogel, and
H.
Laqua,
Retinal photoablation with the Erbium:YAG laser. Initial experimental results for traction-free removal of tissue, Ophthalmologe , vol. 100, no. 2, pp. 115--21, 2003.
Retinal photoablation with the Erbium:YAG laser. Initial experimental results for traction-free removal of tissue, Ophthalmologe , vol. 100, no. 2, pp. 115--21, 2003.
File: | s00347-002-0722-x |
Bibtex: | @article{Hoerauf, title = {[Retinal photoablation with the Erbium:YAG laser. Initial experimental results for traction-free removal of tissue]}, author = {Hoerauf, H. and Brix, A. and Scholz, C. and Winkler, J. and Droge, G. and Birngruber, R. and Vogel, A. and Laqua, H.}, year = {2003}, month = {Feb}, journal = {Ophthalmologe}, volume = 100, number = 2, pages = {115--21}, url = {https://doi.org/10.1007/s00347-002-0722-x}, note = {0941-293X (Print) Comparative Study English Abstract Journal Article}, abstract = {BACKGROUND: To investigate the potential of an Er:YAG laser for precise and traction-free removal of retinal layers in vitro. MATERIAL AND METHODS: Retinal ablation in porcine retinal explants was performed using a free running Er:YAG laser focused either into a low-OH quartz fiber or a sapphire fiber. The explants were treated under air or perfluorodecaline (PFD). The ablation depth was evaluated by optical coherence tomography (OCT) and histology sections. RESULTS: A radiant exposure of 5.0 J/cm(2) under air and PFD resulted in complete transsection of the neurosensory retina.Between 3.5 and 2.0 J/cm(2) the ablation depth and the defect patterns varied markedly and adjacent thermal zones areas were seen. Below 2.0 J/cm(2) no defects could be created in air, whereas under PFD the ablation extended into the ganglion cell layer. Ablations using a sapphire fiber and 2.0 J/cm(2) showed a significantly higher reproducibility of ablation depth, and homogeneous defect patterns limited to the nerve fiber layer could be produced without thermal damage. CONCLUSIONS: The Er:YAG laser system with a low-OH quartz fiber allowed ablation of inner retinal layers in vitro, but revealed a variable ablation depth and low reproducibility.However, a sapphire fiber showed markedly improved results. Therefore its use during vitreoretinal surgery seems possible not only as a cutting device but also as a tool for the ablation of fine retinal structures.}, keywords = {Animals Erbium Fluorocarbons Laser Surgery/*methods *Ophthalmologic Surgical Procedures Retina/anatomy & histology/*surgery Swine} } |
Robert
Huber,
Jacques E.
Moser,
M.
Grutzet, and
Josef
Wachtveitl,
Beyond vibrationally mediated electron transfer: coherent phenomena in a sub-10-femtosecond reaction regime, 2003 European Quantum Electronics Conference. EQEC 2003 (IEEE Cat No.03TH8665) , pp. 158, 2003.
Beyond vibrationally mediated electron transfer: coherent phenomena in a sub-10-femtosecond reaction regime, 2003 European Quantum Electronics Conference. EQEC 2003 (IEEE Cat No.03TH8665) , pp. 158, 2003.
DOI: | 10.1109/EQEC.2003.1314015 |
Bibtex: | @INPROCEEDINGS{1314015, author={Huber, R. and Moser, J.E. and Grutzet, M. and Wachtveitl, J.}, booktitle={2003 European Quantum Electronics Conference. EQEC 2003 (IEEE Cat No.03TH8665)}, title={Beyond vibrationally mediated electron transfer: coherent phenomena in a sub-10-femtosecond reaction regime}, year={2003}, volume={}, number={}, pages={158-}, abstract={This study investigates the systems alizarin as well as coumarin 343 coupled onto TiO/sub 2/ nanoparticles with a femtosecond pump/probe setup. The investigation applies sub 20 fs pump pulses, provided by a noncollinear optical parametric amplifier (NOPA) and a supercontinuum generated in CaF/sub 2/ for a ultrabroadband detection covering a spectral range from 300-960 nm. This work also studies coherent wavepacket propagation succeeding electron transfer at the two systems alizarin/coumarin on TiO/sub 2/. Due to the superfast time scale of the investigated electron transfer (ET) reactions of about 4-7 fs the systems show fundamental differences to conventional molecular ET systems. The ET process is no longer mediated by molecular vibrations and therefore classical molecular ET theories lose their applicability. Results show the real-time coherent excitation of molecular vibrational eigenmodes directly by the ET reaction as well as the generation of phonons during polaron formation in the TiO/sub 2/ lattice. The presented investigations in combination with the classification of the appearing mechanisms could be the basis for an extension of molecular ET theories to superfast systems typically found at molecule/solid state interfaces.}, keywords={}, doi={10.1109/EQEC.2003.1314015}, ISSN={}, month={June},} |
Alfred
Vogel, and
V.
Venugopalan,
Additions and Corrections, Chemical Reviews , vol. 103, no. 5, pp. 2079, 2003.
Additions and Corrections, Chemical Reviews , vol. 103, no. 5, pp. 2079, 2003.
Bibtex: | @article{Vogel, author = {Vogel, A. and Venugopalan, V.}, title = {Additions and Corrections}, journal = {Chemical Reviews}, volume = {103}, number = {5}, pages = {2079}, year = {2003} } |
M.
Niemeyer,
S.
Michels, and
U.
Schmidt-Erfurth,
Three-dimensional imaging of photodynamic effects in choroidal neovascularization and collateral choroid, Investigative Ophthalmology & Visual Science , vol. 44, pp. U297-U297, 2003.
Three-dimensional imaging of photodynamic effects in choroidal neovascularization and collateral choroid, Investigative Ophthalmology & Visual Science , vol. 44, pp. U297-U297, 2003.
H.
Diddens,
F.
Fischer, and
R. H.
Pottier,
In-vivo investigations on dye-enhanced photothermal tumor therapy with a naphthalocyanine derivative, Oftalmologia , vol. 56, no. 1, pp. 59-61, 2003.
In-vivo investigations on dye-enhanced photothermal tumor therapy with a naphthalocyanine derivative, Oftalmologia , vol. 56, no. 1, pp. 59-61, 2003.
Alfred
Vogel, and
V.
Venugopalan,
Mechanisms of Pulsed Laser Ablation of Biological Tissues, Chem. Rev. , vol. 103, pp. 577-644, 2003.
Mechanisms of Pulsed Laser Ablation of Biological Tissues, Chem. Rev. , vol. 103, pp. 577-644, 2003.
M.
Löning,
E.
Lankenau,
C.
Strunck,
M.
Krokowski,
S.
Hillbricht, and
K.
Diedrich,
Optische Kohärenztomographie - ein neues hochauflösendes Schnittbildverfahren als Ergänzung zur Kolposkopie, Geburtsh Frauenheilk , vol. 63, pp. 1158-1161, 2003.
Optische Kohärenztomographie - ein neues hochauflösendes Schnittbildverfahren als Ergänzung zur Kolposkopie, Geburtsh Frauenheilk , vol. 63, pp. 1158-1161, 2003.
C.
Framme,
C.
Alt,
G.
Schuele, and
C.
Lin,
Threshold determinations for selective RPE laser treatment with a laser scanner in rabbits with different scan times in the microsecond regime, Investigative Ophthalmology & Visual Science , vol. 44, pp. U663-U663, 2003.
Threshold determinations for selective RPE laser treatment with a laser scanner in rabbits with different scan times in the microsecond regime, Investigative Ophthalmology & Visual Science , vol. 44, pp. U663-U663, 2003.
2002
Robert
Huber,
Jacques E.
Moser,
Michael
Grätzel, and
Josef
Wachtveitl,
Real-Time Observation of Photoinduced Adiabatic Electron Transfer in Strongly Coupled Dye/Semiconductor Colloidal Systems with a 6 fs Time Constant, J. Phys. Chem. B , vol. 106, no. 25, pp. 6494-6499, 06 2002.
Real-Time Observation of Photoinduced Adiabatic Electron Transfer in Strongly Coupled Dye/Semiconductor Colloidal Systems with a 6 fs Time Constant, J. Phys. Chem. B , vol. 106, no. 25, pp. 6494-6499, 06 2002.
DOI: | 10.1021/jp0155819 |
Bibtex: | @Article{HU_2002_Huber_a, Title = {{Real-Time Observation of Photoinduced Adiabatic Electron Transfer in Strongly Coupled Dye/Semiconductor Colloidal Systems with a 6 fs Time Constant}}, Author = {Huber, Robert and Moser, Jacques-E. and Gr\"{a}tzel, Michael and Wachtveitl, Josef}, Journal = {The Journal of Physical Chemistry B}, Year = {2002}, Month = jun, Number = {25}, Pages = {6494--6499}, Volume = {106}, keywords = {AG-Huber}, Doi = {10.1021/jp0155819}, ISSN = {1520-6106}, Url = {http://pubs.acs.org/doi/abs/10.1021/jp0155819} } |
C.
Framme, and
J.
Roider,
Autofluorescence imaging after selective RPE laser treatment in macular diseases and clinical outcome: a pilot study, British Journal of Ophthalmology , vol. 86, no. 10, pp. 1099-1106, 2002.
Autofluorescence imaging after selective RPE laser treatment in macular diseases and clinical outcome: a pilot study, British Journal of Ophthalmology , vol. 86, no. 10, pp. 1099-1106, 2002.
DOI: | DOI 10.1136/bjo.86.10.1099 |
File: | WOS:000178135200010 |
Bibtex: | @article{Framme2002, author = {Framme, C. and Brinkmann, R. and Birngruber, R. and Roider, J.}, title = {Autofluorescence imaging after selective RPE laser treatment in macular diseases and clinical outcome: a pilot study}, journal = {British Journal of Ophthalmology}, volume = {86}, number = {10}, pages = {1099-1106}, note = {595YE Times Cited:47 Cited References Count:35}, abstract = {Aim: Selective retinal pigment epithelium (RPE) laser treatment is a new technique which selectively damages the RPE while sparing the neural retina. One difficulty is the inability to visualise the laser lesions, The aim of the study was to investigate whether fundus autofluorescence (AF) is changed because of the RPE damage, and thus might be used for treatment control. Additionally, the clinical course of patients with various macular diseases was evaluated. Methods: 26 patients with macular diseases (diabetic maculopathy (DMP), soft drusen maculopathy (AMD), and central serous retinopathy (CSR)) were treated and followed up for at least 6 months. Treatment was performed with a train of repetitive short laser pulses (800 ns) of a frequency doubled Nd:YAG laser (parameters: 532 nm, 50 and 500 pulses at 100 and 500 Hz, retinal spot diameter 200 pm, pulse energies 75-175 muJ). AF was excited by 488 nm and detected by a barrier filter at 500 nm (HRA, Heidelberg Engineering, Germany). Patients were examined by ophthalmoscopy, fluorescein angiography, and autofluorescence measurements at various times after treatment (10 minutes, 1 hour, 1 and 6 weeks, 3, 6, and 12 months). Results: Fluorescein angiography showed leakage from the irradiated areas for about I week after treatment. None of the laser lesions was ophthalmoscopically visible during treatment. Identification of the lesions was possible by AF imaging showing an intensity decay in the irradiated area in 22 out of 26 patients, predominantly in patients with CSR and AMD. Lesions could be identified 10 minutes after treatment as hypoautofluorescent spots, which were more pronounced I hour later. During follow up the laser spots became hyperautofluorescent. In patients with DMP some AF images were less helpful because of diffuse oedema and larger retinal thickness. In these cases ICG angiography was able to confirm therapeutic success very well. Most of the patients have had benefit from the treatment, with best results obtained for CSR patients. Conclusion: Imaging of non-visible selective RPE laser effects can be achieved by AF measurements predominantly in patients without retinal oedema. Therefore, AF may replace invasive fluorescein angiography in many cases to verify therapeutic laser success, Selective laser treatment has the potential to improve the prognosis of macular diseases without the risk of laser scotomas.}, keywords = {retinal-pigment epithelium primate retina fundus autofluorescence scanning ophthalmoscope photocoagulation lipofuscin krypton fluorescence melanin lesions}, ISSN = {0007-1161}, DOI = {DOI 10.1136/bjo.86.10.1099}, url = {<Go to ISI>://WOS:000178135200010}, year = {2002}, type = {Journal Article} } |
C
Framme, and
J
Roider,
Autofluorescence imaging after selective RPE treatment in macular diseases and clinical outcome: a pilot study, Br J Ophthalmol , vol. 86, pp. 1099-1106, 2002.
Autofluorescence imaging after selective RPE treatment in macular diseases and clinical outcome: a pilot study, Br J Ophthalmol , vol. 86, pp. 1099-1106, 2002.
R
Nahrendorf, and
WR
Bauer,
Effect of transmyocardial laser revascularization on myocardial perfusion and left ventricular remodeling after myocardial infarction in rats, Radiology , vol. 225, no. 2(487-493), 2002.
Effect of transmyocardial laser revascularization on myocardial perfusion and left ventricular remodeling after myocardial infarction in rats, Radiology , vol. 225, no. 2(487-493), 2002.
File: | radiol.2252011325 |
Bibtex: | @article{Brinkmann2002, author = {Nahrendorf, M;Hiller, K H;Theisen, D;Hu, K;Waller, C;Kaiser, R;Haase, A;Ertl, G;Brinkmann, R and Bauer, WR}, title = {Effect of transmyocardial laser revascularization on myocardial perfusion and left ventricular remodeling after myocardial infarction in rats}, journal = {Radiology}, volume = {225}, number = {2(487-493)}, url = {https://doi.org/10.1148/radiol.2252011325}, year = {2002}, type = {Journal Article} } |
Alfred
Vogel,
J.
Noack, and
G.
Paltauf,
Femtosecond-laser-produced low-density plasmas in transparent biological media: A tool for the creation of chemical, thermal and thermomechanical effets below the optical brekdown threshold, Proc. SPIE "Commercial and Biological Applications of Ultrafast Lasers IV" , vol. 4633, pp. 23-37, 2002.
Femtosecond-laser-produced low-density plasmas in transparent biological media: A tool for the creation of chemical, thermal and thermomechanical effets below the optical brekdown threshold, Proc. SPIE "Commercial and Biological Applications of Ultrafast Lasers IV" , vol. 4633, pp. 23-37, 2002.
B.
Radt,
J.
Serbin, and
Björn I.
Lange,
High Precision Cell Surgery with Nanoparticles?, Med Laser Appl , vol. 17, pp. 9-14, 2002.
High Precision Cell Surgery with Nanoparticles?, Med Laser Appl , vol. 17, pp. 9-14, 2002.
Yoko
Miura,
T.
Yokoyma,
H.
Tabuchi,
M.
Yamaguchi,
N.
Hosoda, and
Y.
Miyata,
Long-term outcome of juvenile-onset myasthenia ocularis treated by systemic corticosteroid. Japanese review of clinical ophthalmology., Japanese Review of Clinical Ophthalmology , vol. 96, no. 11, pp. 1133-1135, 2002.
Long-term outcome of juvenile-onset myasthenia ocularis treated by systemic corticosteroid. Japanese review of clinical ophthalmology., Japanese Review of Clinical Ophthalmology , vol. 96, no. 11, pp. 1133-1135, 2002.
DOI: | https://www.researchgate.net/publication/334749034_Long-term_outcome_of_juvenile-onset_myasthenia_ocularis_treated_by_systemic_corticosteroid |
Bibtex: | @article{Miura2002, author = {Y, Miura and T, Yokoyma and H, Tabuchi and M, Yamaguchi and N, Hosoda and Y, Miyata}, title = {Long-term outcome of juvenile-onset myasthenia ocularis treated by systemic corticosteroid. Japanese review of clinical ophthalmology. }, journal = {Japanese Review of Clinical Ophthalmology}, volume = {96}, number = {11}, pages = {1133-1135}, year = {2002} } |
C.
Wirbelauer,
C.
Scholz,
H.
Hoerauf,
D. T.
Pham, and
H.
Laqua,
Noncontact corneal pachymetry with slit lamp-adapted optical coherence tomography, American Journal of Ophthalmology , vol. 133, no. 4, pp. 444-450, 2002.
Noncontact corneal pachymetry with slit lamp-adapted optical coherence tomography, American Journal of Ophthalmology , vol. 133, no. 4, pp. 444-450, 2002.
DOI: | Pii S0002-9394(01)01425-8 Doi 10.1016/S0002-9394(01)01425-8 |
File: | WOS:000174798200002 |
Bibtex: | @article{Wirbelauer2002, author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Pham, D. T. and Laqua, H. and Birngruber, R.}, title = {Noncontact corneal pachymetry with slit lamp-adapted optical coherence tomography}, journal = {American Journal of Ophthalmology}, volume = {133}, number = {4}, pages = {444-450}, note = {538DE Times Cited:73 Cited References Count:35}, abstract = {PURPOSE: The purpose of this study was to determine the accuracy, the reproducibility, and the limits of agreement of noncontact central corneal thickness measurement with slit lamp adapted optical coherence tomography (OCT). DESIGN: Nonrandomized comparative clinical trial. METHODS: In a prospective comparative observational study, a total of 108 consecutive patients ( 108 eyes) with normal corneas (92 eyes) and different corneal alters ations (16 eyes) participated. Six sequential measure. ments of the central corneal thickness with slit lamp-adapted OCT and with ultrasound (US) pachymetry at 1640 ms(-1) were performed. The main outcome measures were accuracy, reproducibility assessed with precision and coefficient of variation (CV), and limits of agreement of central corneal thickness measurement. RESULTS: The mean central corneal thickness values were 541 +/- 43 mum (OCT) and 549 +/- 44 mum (US) with a mean precision of +/- 5.8 mum (CV 1.08%) and of +/- 4.0 mum (CV 0.73%), respectively. The method comparison revealed equivalence (+/- 2SD) in the 5% range with a mean difference between both methods of 7.9 mum (1-45%). The relative error was 8.7 mum (1.6%), which corresponded to limits of agreement (+/- 2SD) ranging from -9.5 mum to 25.3 mum. CONCLUSIONS: Central corneal pachymetry with slit lamp,adapted OCT revealed, for clinical purposes, an excellent accuracy and reproducibility with a high degree of agreement compared with US pachymetry. Thus, the presented OCT system seems to be a promising diagnostic modality to objectively measure corneal thickness in a convenient noncontact mode. (C) 2002 by Elsevier Science Inc. All rights reserved.}, keywords = {in-situ keratomileusis anterior segment human-eye thickness interferometry regression precision}, ISSN = {0002-9394}, DOI = {Pii S0002-9394(01)01425-8 Doi 10.1016/S0002-9394(01)01425-8}, url = {<Go to ISI>://WOS:000174798200002}, year = {2002}, type = {Journal Article} } |
A
Brix,
A
Vogel,
J
Winkler,
G
Dröge,
H
Laqua, and
H
Hoerauf,
Photoablation innerer Netzhautschichten mit dem Erbium: YAG-Laser in vitro, Focus Mul / Medizinische Universität <Lübeck> , vol. 19, no. 1, pp. 35, 2002.
Photoablation innerer Netzhautschichten mit dem Erbium: YAG-Laser in vitro, Focus Mul / Medizinische Universität <Lübeck> , vol. 19, no. 1, pp. 35, 2002.
File: | 24278.pdf |
Bibtex: | @article{Brix2002, author = {Brix, A and Vogel, A and Winkler, J and Dröge, G and Birngruber, R and Laqua, H and Hoerauf, H}, title = {Photoablation innerer Netzhautschichten mit dem Erbium: YAG-Laser in vitro}, journal = {Focus Mul / Medizinische Universität <Lübeck>}, volume = {19}, number = {1}, pages = {35}, ISSN = {0940-9998}, url = {http://www.zbmed.de/ccmedimages/2002/24278.pdf}, year = {2002}, type = {Journal Article} } |
K.
Nahen, and
Alfred
Vogel,
Plume dynamics and shielding by the ablation plume during Er:YAG laser ablation, Journal of Biomedical Optics , vol. 7, no. 2, pp. 165-178, 2002.
Plume dynamics and shielding by the ablation plume during Er:YAG laser ablation, Journal of Biomedical Optics , vol. 7, no. 2, pp. 165-178, 2002.
C.
Framme,
G.
Schuele,
J.
Roider, and
D.
Kracht,
Threshold determinations for selective retinal pigment epithelium damage with repetitive pulsed microsecond laser systems in rabbits, Ophthalmic Surgery and Lasers , vol. 33, no. 5, pp. 400-409, 2002.
Threshold determinations for selective retinal pigment epithelium damage with repetitive pulsed microsecond laser systems in rabbits, Ophthalmic Surgery and Lasers , vol. 33, no. 5, pp. 400-409, 2002.
C.
Framme,
G.
Schuele, and
J.
Roider,
Threshold determinations for selective RPE damage with repetitively pulsed microsecond laser systems in rabbits, Investigative Ophthalmology & Visual Science , vol. 43, pp. U595-U595, 2002.
Threshold determinations for selective RPE damage with repetitively pulsed microsecond laser systems in rabbits, Investigative Ophthalmology & Visual Science , vol. 43, pp. U595-U595, 2002.
N
Koop,
M
Özdemir,
C
Alt,
G
Schüle, and
C P
Lin,
Selective damage of pigmented cells by means of a rapidly scanned cw laser beam, Proc SPIE , vol. 4617, pp. 134-140, 2002.
Selective damage of pigmented cells by means of a rapidly scanned cw laser beam, Proc SPIE , vol. 4617, pp. 134-140, 2002.
N.
Koop,
M.
Oezdemir,
C.
Alt,
G.
Schuele, and
C. P.
Lin,
Selective RPE damage by means of a rapidly scanned cw laser beam, Investigative Ophthalmology & Visual Science , vol. 43, pp. U595-U595, 2002.
Selective RPE damage by means of a rapidly scanned cw laser beam, Investigative Ophthalmology & Visual Science , vol. 43, pp. U595-U595, 2002.
Alfred .
Vogel,
P.
Schweiger,
A.
Frieser, and
M.
Asiyo,
Intraocular Nd: YAG Laser Surgery: Light-Tissue Interaction, Damage Range, and Reduction of Collateral Effects, IEEE J Quant Electr , vol. 26, pp. 2241-2260, 2002.
Intraocular Nd: YAG Laser Surgery: Light-Tissue Interaction, Damage Range, and Reduction of Collateral Effects, IEEE J Quant Electr , vol. 26, pp. 2241-2260, 2002.
Alfred
Vogel, and
G.
Paltauf,
Low-density plasmas below the optical breakdown threshold: potential hazard for multiphoton microscopy, and a tool for the manipulation of intracellular events, Proc SPIE "Multiphoton Microscopy in the Biomedical Sciences II" , vol. 4620, pp. 202-216, 2002.
Low-density plasmas below the optical breakdown threshold: potential hazard for multiphoton microscopy, and a tool for the manipulation of intracellular events, Proc SPIE "Multiphoton Microscopy in the Biomedical Sciences II" , vol. 4620, pp. 202-216, 2002.
File: | 12.470693.short |
Bibtex: | @article{Vogel-2002-2, author = {Vogel, A. and Hüttmann, G. and Paltauf, G.}, title = {Low-density plasmas below the optical breakdown threshold: potential hazard for multiphoton microscopy, and a tool for the manipulation of intracellular events}, journal = {Proc SPIE "Multiphoton Microscopy in the Biomedical Sciences II"}, volume = {4620}, pages = {202-216}, year = { 2002}, url = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/4620/0000/Low-density-plasmas-below-the-optical-breakdown-threshold--potential/10.1117/12.470693.short?SSO=1} } |
Alfred
Vogel,
P.
Schmidt, and
B.
Flucke,
Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses, SPIE Proc. Laser Tissue Interaction XIII , vol. 4617A, 2002.
Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses, SPIE Proc. Laser Tissue Interaction XIII , vol. 4617A, 2002.
File: | 12.472512.short |
Bibtex: | @article{Vogel-2002-3, author = {Vogel, A. and Schmidt, P. and Flucke, B.}, title = {Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses}, journal = {SPIE Proc. Laser Tissue Interaction XIII}, volume = {4617A}, year = { 2002}, url = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/4617/0000/Minimization-of-thermomechanical-side-effects-and-increase-of-ablation-efficiency/10.1117/12.472512.short} } |
H.
Hoerauf,
C.
Scholz,
P.
Koch,
R.
Engelhardt, and
H.
Laqua,
Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye, Arch Ophthalmol , vol. 120, no. 6, pp. 816-9, 2002.
Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye, Arch Ophthalmol , vol. 120, no. 6, pp. 816-9, 2002.
File: | query.fcgi |
Bibtex: | @article{Hoerauf2002, author = {Hoerauf, H. and Scholz, C. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.}, title = {Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye}, journal = {Arch Ophthalmol}, volume = {120}, number = {6}, pages = {816-9}, note = {0003-9950 (Print) Journal Article}, abstract = {OBJECTIVE: To present a new imaging method for the anterior segment of the eye. METHODS: Transscleral optical coherence tomographic images were generated in healthy volunteers using a slitlamp-adapted prototype equipped with a superluminescence diode with an infrared wavelength of 1310 nm. RESULTS: The optical coherence tomographic system used allowed penetration of human sclera in vivo and high-resolution, cross-sectional imaging of the anterior chamber angle and the ciliary body. CONCLUSION: The 1310-nm optical coherence tomographic image shows a significant potential as a noninvasive diagnostic tool for the anterior segment of the eye.}, keywords = {Anatomy, Cross-Sectional/*methods Anterior Eye Segment/*anatomy & histology *Diagnostic Techniques, Ophthalmological Humans Interferometry Light Sclera Tomography/methods}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12049589}, year = { 2002}, type = {Journal Article} } |
G.S.
Keen,
Alfred
Vogel, and
J.R.
Blake,
The final stage of the collapse of a cavitation bubble close to a rigid boundary, Phys Fluids , vol. 14, pp. 85-92, 2002.
The final stage of the collapse of a cavitation bubble close to a rigid boundary, Phys Fluids , vol. 14, pp. 85-92, 2002.
U. M.
Schmidt-Erfurth,
W.
Ahlswede,
S.
Michels, and
H.
Laqua,
Three-dimensional analysis of photodynamic therapy (PDT)-induced vascular effects in choroidal neovascularization (CNV) and choroid: A two year follow-up, Investigative Ophthalmology & Visual Science , vol. 43, pp. U1143-U1143, 2002.
Three-dimensional analysis of photodynamic therapy (PDT)-induced vascular effects in choroidal neovascularization (CNV) and choroid: A two year follow-up, Investigative Ophthalmology & Visual Science , vol. 43, pp. U1143-U1143, 2002.
H.
Hoerauf,
J.
Winkler,
C.
Scholz,
C.
Wirbelauer,
R. S.
Gordes,
P.
Koch,
R.
Engelhardt, and
H.
Laqua,
Transscleral optical coherence tomography--an experimental study in ex-vivo human eyes, Lasers Surg Med , vol. 30, no. 3, pp. 209-15, 2002.
Transscleral optical coherence tomography--an experimental study in ex-vivo human eyes, Lasers Surg Med , vol. 30, no. 3, pp. 209-15, 2002.
File: | query.fcgi |
Bibtex: | @article{Hoerauf2002, author = {Hoerauf, H. and Winkler, J. and Scholz, C. and Wirbelauer, C. and Gordes, R. S. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.}, title = {Transscleral optical coherence tomography--an experimental study in ex-vivo human eyes}, journal = {Lasers Surg Med}, volume = {30}, number = {3}, pages = {209-15}, note = {0196-8092 (Print) Journal Article}, abstract = {BACKGROUND AND OBJECTIVE: To evaluate the potentials of a 1310-nm optical coherence tomography (OCT) system to penetrate the highly backscattering sclera in enucleated human eyes and provide visualization of intraocular structures by transscleral imaging. STUDY DESIGN/MATERIALS AND METHODS: OCT-images were generated by an experimental prototype (Medical Laser Center, Lubeck, Germany) using a superluminescence diode with a wavelength of 1310 nm. OCT-images were taken from two enucleated human eyes using 100-200 axial scans with 60 Hz line scan frequency and compared to subsequent histologic sections. RESULTS: Transscleral OCT allowed penetration of the sclera and the anterior chamber angle could be completely identified. Some change within the anterior eye segment could be demonstrated with high accuracy. Additionally, limited demonstration of the ciliary body region was achieved. Due to limited signal intensity no detailed imaging of the pars plana and pars plicata region was possible. However, more posterior measurements allowed transscleral visualization of a retinal detachment. CONCLUSIONS: OCT using lightsources with a wavelength longer than that used in conventional OCT provides a promising imaging technique at high resolution allowing transscleral imaging of the anterior eye segment.}, keywords = {Anterior Chamber/cytology Anterior Eye Segment/cytology Ciliary Body/cytology Equipment Design Eye/*cytology Humans Tomography/instrumentation/*methods}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11891740}, year = {2002}, type = {Journal Article} } |
R.
Muller-Velten,
K.
Hillmann,
J.
Noack, and
U.
Schmidt-Erfurth,
Topographic imaging and quantification of retinal vascular leakage in venous branch occlusion, Investigative Ophthalmology & Visual Science , vol. 43, pp. U805-U805, 2002.
Topographic imaging and quantification of retinal vascular leakage in venous branch occlusion, Investigative Ophthalmology & Visual Science , vol. 43, pp. U805-U805, 2002.
V.
Venugopalan,
A.
Guerra,
K.
Nahen, and
Alfred
Vogel,
Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation, Phys Rev Let , vol. 88, no. 7, pp. 078103 (1-4), 2002.
Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation, Phys Rev Let , vol. 88, no. 7, pp. 078103 (1-4), 2002.
2001
Robert
Huber,
Helmut
Satzger,
Wolfgang
Zinth, and
Josef
Wachtveitl,
Noncollinear optical parametric amplifiers with output parameters improved by the application of a white light continuum generated in CaF2, Optics Communications , vol. 194, no. 4, pp. 443-448, 07 2001.
Noncollinear optical parametric amplifiers with output parameters improved by the application of a white light continuum generated in CaF2, Optics Communications , vol. 194, no. 4, pp. 443-448, 07 2001.
DOI: | 10.1016/S0030-4018(01)01324-4 |
Bibtex: | @article{HUBER2001443, title = {Noncollinear optical parametric amplifiers with output parameters improved by the application of a white light continuum generated in CaF2}, journal = {Optics Communications}, volume = {194}, number = {4}, pages = {443-448}, year = {2001}, issn = {0030-4018}, doi = {https://doi.org/10.1016/S0030-4018(01)01324-4}, url = {https://www.sciencedirect.com/science/article/pii/S0030401801013244}, author = {Robert Huber and Helmut Satzger and Wolfgang Zinth and Josef Wachtveitl}, keywords = {Femtosecond pulses, Parametric amplification, White light continuum, Supercontinuum, Frequency conversion, Amplification bandwidth, Calcium fluoride (CaF)}, abstract = {We report the drastic improvement of output parameters of femtosecond noncollinear optical parametric amplifiers by applying supercontinuum seed pulses generated in CaF2 instead of sapphire and imaging via all reflective optics. Features of the setup are broad amplification bandwidths up to 310 THz (470–910 nm), an almost Gaussian beam profile, a divergence with M2 factor of less than 1.4, pulse to pulse energy fluctuations of less than 2.5% and compressibility of the pulses down to 16 fs. The high intensity of the supercontinuum seed pulse (80 nJ) yields a quantum efficiency for the conversion of pump to signal of more than 30%. Even for short wavelengths e.g. at 470 nm pulse energies above 30 μJ were obtained for 110 μJ of 400 nm pump light.} } |
VIP Study group,
Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Pathologic Myopia with Verteporfin: One-Year Results of a Randomized Clinical Trial - VIP Report #1., Ophthalmology , vol. 108, pp. 841-852, 2001.
Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Pathologic Myopia with Verteporfin: One-Year Results of a Randomized Clinical Trial - VIP Report #1., Ophthalmology , vol. 108, pp. 841-852, 2001.
Reginald
Birngruber,
J.
Arnold,
D.
Kilmartin,
J.
Olson,
S.
Neville,
K.
Robinson,
A.
Laird,
C.
Richmond,
A.
Farrow,
S.
McKay,
R.
McKechnie,
G.
Evans,
T. M.
Aaberg,
J.
Brower,
R.
Waldron,
D.
Loupe,
J.
Gillman,
B.
Myles,
D. A.
Saperstein,
A. P.
Schachat,
N. M.
Bressler,
S. B.
Bressler,
P.
Nesbitt,
T.
Porter,
P.
Hawse,
M.
Harnett,
A.
Eager,
J.
Belt,
D.
Cain,
D.
Emmert,
T.
George,
M.
Herring,
J.
McDonald,
J.
Mones,
B.
Corcostegui,
M.
Gilbert,
N.
Duran,
M.
Sisquella,
A.
Nolla,
A.
Margalef,
J. W.
Miller,
E. S.
Gragoudas,
A. M.
Lane,
N.
Emmanuel,
A.
Holbrook,
C.
Evans,
U. S.
Lord,
D. K.
Walsh,
C. D.
Callahan,
J. L.
DuBois,
J.
Moy,
A. G.
Kenney,
I.
Milde,
E. S.
Platz,
H.
Lewis,
P. K.
Kaiser,
L. J.
Holody,
E.
Lesak,
S.
Lichterman,
H.
Siegel,
A.
Fattori,
G.
Ambrose,
T.
Fecko,
D.
Ross,
J.
Conway,
L.
Singerman,
H.
Zegarra,
M.
Novak,
M.
Bartel,
K.
Tilocco-DuBois,
M.
Ilc,
S.
Schura,
S.
Joyce,
V.
Tanner,
P.
Rowe,
S.
Smith-Brewer,
G.
Greanoff,
G.
Daley,
J.
DuBois,
D.
Lehnhardt,
D.
Kukula,
G. E.
Fish,
B. F.
Jost,
R.
Anand,
D.
Callanan,
S.
Arceneaux,
J.
Arnwine,
P.
Ellenich,
J.
King,
H.
Aguado,
R.
Rollins,
T.
Anderson,
C.
Nork,
K.
Duignan,
B.
Boleman,
B.
Jurklies,
D.
Pauleikhoff,
A.
Hintzmann,
M.
Fischer,
C.
Sowa, and
others,
Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2, American Journal of Ophthalmology , vol. 131, no. 5, pp. 541-560, 2001.
Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2, American Journal of Ophthalmology , vol. 131, no. 5, pp. 541-560, 2001.
Alfred
Vogel,
P.
Schmidt, and
B.
Flucke,
Minimization of thermomechanical side effects in IR ablation by use of Q-switched double pulses, Laser-Tissue Interaction XII. SPIE , vol. 4257, pp. 184-191, 2001.
Minimization of thermomechanical side effects in IR ablation by use of Q-switched double pulses, Laser-Tissue Interaction XII. SPIE , vol. 4257, pp. 184-191, 2001.
Akira
Obana,
Yuko
Gohto,
Sonomi
Wada,
Yoko
Miura,
Tokuhiko
Miki, and
Akira
Chou,
Surgical outcomes in removal of epimacular membranes, Journal of ophthalmic surgery , vol. 14, no. 2, pp. 253-256, 2001.
Surgical outcomes in removal of epimacular membranes, Journal of ophthalmic surgery , vol. 14, no. 2, pp. 253-256, 2001.
K.
Nahen, and
Alfred
Vogel,
Shielding by the ablation plume during Er:YAG laser ablation, SPIE Proc. , vol. 4257, pp. 303-311, 2001.
Shielding by the ablation plume during Er:YAG laser ablation, SPIE Proc. , vol. 4257, pp. 303-311, 2001.
H Roider,
Selective RPE laser treatment in macular diseases: Clinical results., Invest Ophthal & VisScie , pp. S695-S695, 2001.
Selective RPE laser treatment in macular diseases: Clinical results., Invest Ophthal & VisScie , pp. S695-S695, 2001.
Study group TAP,
Photodynamic Therapy of Subfovieal Choroidal Neovascularization in Age-Related Macular Degeneration with Verteporfin - Two-Year Results of 2 Randomized Clinical Trials, TAP Report 2, Arch Ophthalmol , vol. 119, pp. 198-207, 2001.
Photodynamic Therapy of Subfovieal Choroidal Neovascularization in Age-Related Macular Degeneration with Verteporfin - Two-Year Results of 2 Randomized Clinical Trials, TAP Report 2, Arch Ophthalmol , vol. 119, pp. 198-207, 2001.
Reginald
Birngruber,
J.
Arnold,
D.
Kilmartin,
J.
Olson,
S.
Neville,
K.
Robinson,
A.
Laird,
C.
Richmond,
A.
Farrow,
S.
McKay,
D. A.
Saperstein,
T. M.
Aaberg,
J. B.
Johnson,
R.
Waldron,
D.
Loupe,
J.
Gillman,
B.
Myles,
A. P.
Schachat,
N. M.
Bressler,
S. B.
Bressler,
P.
Nesbitt,
T.
Porter,
P.
Hawse,
M.
Hartnett,
A.
Eager,
J.
Belt,
D.
Cain,
D.
Emmert,
T.
George,
M.
Herring,
J.
McDonald,
J.
Mones,
B.
Corcostegui,
M.
Gilbert,
N.
Duran,
M.
Sisquella,
A.
Nolla,
A.
Margalef,
J. W.
Miller,
E. S.
Gragoudas,
A. M.
Lane,
N.
Emmanuel,
A.
Holbrook,
C.
Evans,
U. S.
Lord,
D. K.
Walsh,
C. D.
Callahan,
J. L.
DuBois,
H.
Lewis,
P. K.
Kaiser,
L. J.
Holody,
E.
Lesak,
S.
Lichterman,
H.
Siegel,
A.
Fattori,
G.
Ambrose,
T.
Fecko,
D.
Ross,
L.
Singerman,
H.
Zegarra,
M.
Novak,
M.
Bartel,
K.
Tilocco-DuBois,
M.
Iic,
S.
Schura,
S. J.
Mayes,
V.
Tanner,
P.
Rowe,
S.
Smith-Brewer,
D.
Kukula,
G.
Greanoff,
G.
Daley,
J.
DuBois,
D.
Lehnhardt,
G. E.
Fish,
B. F.
Jost,
R.
Anand,
D.
Callanan,
S.
Arceneaux,
J.
Arnwine,
P.
Ellenich,
J.
King,
H.
Aguado,
R.
Rollins,
B.
Jurklies,
D.
Pauleikhoff,
A.
Hintzmann,
M.
Fischer,
C.
Sowa,
E.
Behne,
C. J.
Pournaras,
G.
Donati,
A. D.
Kapetanios,
K.
Cavaliere,
S.
Guney-Wagner,
N.
Gerber,
M.
Sickenberg,
V.
Sickenberg,
A.
Gans,
B.
Hosner, and
others,
Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin - 1-year results of a randomized clinical trial - VIP report no. 1, Ophthalmology , vol. 108, no. 5, pp. 841-852, 2001.
Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin - 1-year results of a randomized clinical trial - VIP report no. 1, Ophthalmology , vol. 108, no. 5, pp. 841-852, 2001.
Alfred
Vogel, and
J.
Noack,
Numerical simulation of optical breakdown for cellular surgery at nanosecond to femtosecond time scales, Laser- Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy. SPIE , vol. 4433, pp. 70-80, 2001.
Numerical simulation of optical breakdown for cellular surgery at nanosecond to femtosecond time scales, Laser- Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy. SPIE , vol. 4433, pp. 70-80, 2001.
J.
Serbin,
B.
Radt, and
Björn I.
Lange,
Model system for investigating laser-induced subcellular microeffects., Proc SPIE , vol. 4257, pp. 398-409, 2001.
Model system for investigating laser-induced subcellular microeffects., Proc SPIE , vol. 4257, pp. 398-409, 2001.
H. G.
Elsner,
M.
Niemeyer,
H.
Laqua, and
U.
Schmidt-Erfurth,
Imaging of choroidal neovascularization: A comparison of optical coherence tomography and topographic angiography., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S795-S795, 2001.
Imaging of choroidal neovascularization: A comparison of optical coherence tomography and topographic angiography., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S795-S795, 2001.
U.
Schmidt-Erfurth,
S.
Teschner, and
J.
Noack,
Three-dimensional topographic angiography in chorioretinal vascular disease, Investigative Ophthalmology & Visual Science , vol. 42, no. 10, pp. 2386-2394, 2001.
Three-dimensional topographic angiography in chorioretinal vascular disease, Investigative Ophthalmology & Visual Science , vol. 42, no. 10, pp. 2386-2394, 2001.
Nubuyo
Yanagihara,
Yoko
Miura,
Mitsuyasu
Moriwaki,
Kunihiko
Shiraki,
Hitoshi
Imamura,
Mayumi
Kaida, and
Tokuhiko
Miki,
Hepatocyte growth factor promotes epithelial morphogenesis and occludin linkage to the cytoskeleton in cultured retinal pigment epithelial cells, Graefes Arch Clin Exp Ophthalmol , vol. 239, no. 8, pp. 619-27, 2001.
Hepatocyte growth factor promotes epithelial morphogenesis and occludin linkage to the cytoskeleton in cultured retinal pigment epithelial cells, Graefes Arch Clin Exp Ophthalmol , vol. 239, no. 8, pp. 619-27, 2001.
DOI: | 10.1007/s004170100327 |
Bibtex: | @article{Miura2001, author = {Yanagihara, N. and Miura, Y. and Moriwaki, M. and Shiraki, K. and Imamura, H. and Kaida, M. and Miki, T.}, title = {Hepatocyte growth factor promotes epithelial morphogenesis and occludin linkage to the cytoskeleton in cultured retinal pigment epithelial cells}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {239}, number = {8}, pages = {619-27}, note = {Yanagihara, N Miura, Y Moriwaki, M Shiraki, K Imamura, H Kaida, M Miki, T eng Research Support, Non-U.S. Gov't Germany 2001/10/05 10:00 Graefes Arch Clin Exp Ophthalmol. 2001 Aug;239(8):619-27.}, abstract = {BACKGROUND: Although hepatocyte growth factor (HGF) is also known as scatter factor, it induces epithelial morphogenesis in cultured bovine retinal pigment epithelial (RPE) cells. To elucidate the mechanism of epithelial morphogenesis, we investigated the influence of HGF on occludin, a major component of tight junctions. METHODS: RPE cells were plated on collagen type 1-coated chamber slides or dishes, 20 ng/ml HGF was added and the cells were incubated for 1 week. Cells were harvested at several time-points, and occludin expression was examined by immunohistochemistry. Detergent extraction protocols to identify the intensity of occludin linkage to the cytoskeleton were also used. Occludin expression was determined semiquantitatively by Western blotting. RESULTS: Fluorescence microscopy revealed that HGF treatment increased the levels of insoluble occludin at the cell borders after detergent extraction. These level of insoluble occludin and the associated epithelial morphology were maintained for more than 3 weeks after withdrawal of HGF, whereas cells not treated with HGF had a fibroblastic appearance. Western blotting also showed that insoluble occludin was more abundant in HGF-treated cells. Furthermore, immunoreactive bands of insoluble occludin were somewhat larger than those of soluble occludin, suggesting that insoluble occludin may be modified in comparison to soluble occludin. CONCLUSION: Our results suggest that HGF promotes linkage of occludin to the cytoskeleton. HGF may become a therapeutic candidate in physiological recovery of RPE cells and in preparation of RPE monolayers for transplantation.}, keywords = {Animals Blotting, Western Cattle Cells, Cultured Cytoskeleton/*metabolism Fluorescent Antibody Technique, Indirect Hepatocyte Growth Factor/*pharmacology Membrane Proteins/*metabolism Microscopy, Fluorescence Morphogenesis Occludin Pigment Epithelium of Eye/cytology/*drug effects/metabolism}, year = {2001} } |
C.
Wirbelauer,
C.
Scholz,
H.
Hoerauf,
G. O.
Bastian,
R.
Engelhardt, and
H.
Laqua,
Examination of the cornea using optical coherence tomography, Ophthalmologe , vol. 98, no. 2, pp. 151-156, 2001.
Examination of the cornea using optical coherence tomography, Ophthalmologe , vol. 98, no. 2, pp. 151-156, 2001.
DOI: | DOI 10.1007/s003470170176 |
File: | WOS:000167041400005 |
Bibtex: | @article{Wirbelauer2001, author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Bastian, G. O. and Engelhardt, R. and Birngruber, R. and Laqua, H.}, title = {Examination of the cornea using optical coherence tomography}, journal = {Ophthalmologe}, volume = {98}, number = {2}, pages = {151-156}, note = {403KQ Times Cited:34 Cited References Count:18}, abstract = {Introduction. This study evaluated the clinical use of optical coherence tomography (OCT) for two-dimensional representation of the cornea. Patients and methods. Noncontact slit-lamp-adapted OCT was used in selected cases to evaluate pathologically altered corneas and to measure the central corneal thickness and curvature. Results. OCT provided correlation between differences in reflection and morphological changes. Scar tissue resulted in hyperreflective light scattering, wheras cystic lesions were hyporeflective. Precise biomorphometry also allowed representation of intrastromal and retrocorneal changes. Central corneal thickness measured by OCT yielded reproducible values and corn be calculated from the optical signals of the corneal surface. Conclusions. OCT provides high-resolution representation of the cornea and exact evaluation of its morphology, thickness, and curvature. Due to the noncontact, simple,and rapid examination using the slitlamp the corneal OCT method is a promising additional diagnostic modality.}, keywords = {optical coherence tomography cornea pachymetry profilometry thickness measurements in-vivo pachymetry topography eye}, ISSN = {0941-293X}, DOI = {DOI 10.1007/s003470170176}, url = {<Go to ISI>://WOS:000167041400005}, year = {2001}, type = {Journal Article} } |
K.
Nahen,
P.
Schmidt, and
Alfred
Vogel,
Dynamics of laser-induced cavitation bubbles near elastic boundary, J Fluid Mech , vol. 433, pp. 251-281, 2001.
Dynamics of laser-induced cavitation bubbles near elastic boundary, J Fluid Mech , vol. 433, pp. 251-281, 2001.
Emil-Alexandru
Brujan,
Kester
Nahen,
Peter
Schmidt, and
Alfred
Vogel,
Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus, Journal of Fluid Mechanics , vol. 433, pp. 283-314, 2001.
Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus, Journal of Fluid Mechanics , vol. 433, pp. 283-314, 2001.
G.
Schuele,
E.
Joachimmeyer, and
J.
Roider,
Determination of absolute fundus temperatures during retinal laser photocoagulation and selective RPE treatment., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S696-S696, 2001.
Determination of absolute fundus temperatures during retinal laser photocoagulation and selective RPE treatment., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S696-S696, 2001.
A
Obana,
Yuko
Gohto,
Yoko
Miura,
Sonomi
Wada, and
T
Miki,
Clinical findings and courses of age-related maculopathy., Japanese Journal of Clinical Ophthalmology , vol. 55, no. 6, pp. 1229-1234, 2001.
Clinical findings and courses of age-related maculopathy., Japanese Journal of Clinical Ophthalmology , vol. 55, no. 6, pp. 1229-1234, 2001.
C.
Framme,
G.
Schuele, and
J.
Roider,
Autofluorescence imaging after selective RPE laser treatment in macular diseases: A pilot study., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S703-S703, 2001.
Autofluorescence imaging after selective RPE laser treatment in macular diseases: A pilot study., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S703-S703, 2001.
U. M.
Schmidt-Erfurth,
M.
Niemeyer,
S.
Michels, and
H.
Laqua,
Three-dimensional imaging of dynamic and structural vascular changes induced by photodynamic therapy., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S512-S512, 2001.
Three-dimensional imaging of dynamic and structural vascular changes induced by photodynamic therapy., Investigative Ophthalmology & Visual Science , vol. 42, no. 4, pp. S512-S512, 2001.
W.
Schneider-Brachert,
H. J.
Linde,
S.
Miehlke,
E.
Bayerdorffer, and
N.
Lehn,
Susceptibility of clinical ciprofloxacin-resistant isolates of Helicobacter pylori to new fluoroquinolones, Gut , vol. 49, pp. A96-A96, 2001.
Susceptibility of clinical ciprofloxacin-resistant isolates of Helicobacter pylori to new fluoroquinolones, Gut , vol. 49, pp. A96-A96, 2001.
C.
Wirbelauer,
C.
Scholz,
H.
Hoerauf,
G. O.
Bastian,
R.
Engelhardt, and
H.
Laqua,
Untersuchungen der Hornhaut mittels optischer Kohärenztomographie., Ophthalmologe , vol. 98, pp. 151-156, 2001.
Untersuchungen der Hornhaut mittels optischer Kohärenztomographie., Ophthalmologe , vol. 98, pp. 151-156, 2001.
VIP Study group,
Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two year results of a randomized clinical trail including lesions with occult with no classic choroidal neovascularization - Verteporfin In Photodynamic Therapy, Report #2, Am J Ophthalmol , vol. 131, pp. 541-560, 2001.
Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: two year results of a randomized clinical trail including lesions with occult with no classic choroidal neovascularization - Verteporfin In Photodynamic Therapy, Report #2, Am J Ophthalmol , vol. 131, pp. 541-560, 2001.
2000
Robert
Huber,
Sebastian
Spörlein,
Jacques E.
Moser,
Michael
Grätzel, and
Josef
Wachtveitl,
The Role of Surface States in the Ultrafast Photoinduced Electron Transfer from Sensitizing Dye Molecules to Semiconductor Colloids, The Journal of Physical Chemistry B , vol. 104, no. 38, pp. 8995-9003, 09 2000. American Chemical Society.
The Role of Surface States in the Ultrafast Photoinduced Electron Transfer from Sensitizing Dye Molecules to Semiconductor Colloids, The Journal of Physical Chemistry B , vol. 104, no. 38, pp. 8995-9003, 09 2000. American Chemical Society.
DOI: | 10.1021/jp9944381 |
Bibtex: | @Article{HU_2000_Huber_a, Title = {{The Role of Surface States in the Ultrafast Photoinduced Electron Transfer from Sensitizing Dye Molecules to Semiconductor Colloids}}, Author = {Huber, Robert and Sp\"{o}rlein, Sebastian and Moser, Jacques E and Gr\"{a}tzel, Michael and Wachtveitl, Josef}, Journal = {The Journal of Physical Chemistry B}, Year = {2000}, Month = sep, Number = {38}, Pages = {8995--9003}, Volume = {104}, keywords = {AG-Huber}, Doi = {10.1021/jp9944381}, ISSN = {1520-6106}, Publisher = {American Chemical Society}, Url = {http://pubs.acs.org/doi/abs/10.1021/jp9944381} } |
J.
Kampmeier, and
B.
Radt,
Thermal and biomechanical parameters of porcine cornea, Cornea , vol. 19(3), pp. 355-63, 2000.
Thermal and biomechanical parameters of porcine cornea, Cornea , vol. 19(3), pp. 355-63, 2000.
File: | 12484883_Thermal_and_Biomechanical_Parameters_of_Porcine_Cornea |
Bibtex: | @article{Kampmeier-2000, author = {Kampmeier, J. and Radt, B. and Birngruber, R. and Brinkmann, R.}, title = {Thermal and biomechanical parameters of porcine cornea}, journal = {Cornea}, volume = {19(3)}, year = { 2000}, url = { https://www.researchgate.net/publication/12484883_Thermal_and_Biomechanical_Parameters_of_Porcine_Cornea}, pages = {355-63}, note = {0277-3740 (Print) Journal Article Research Support, Non-U.S. Gov't}, abstract = {PURPOSE: New methods in refractive surgery require a considerable understanding of the material "cornea" and are often studied by theoretical modeling in order to gain insight into the procedure and an optimized approach to the technique. The quality of these models is highly dependent on the preciseness of its input parameters. Porcine cornea often is used as a model in preclinical studies because of its similarity to man and its availability. METHODS: The important physical parameters for biomechanical deformation, heat conduction, and collagen denaturation kinetics have been determined for porcine cornea. Experimental methods include densitometry, calorimetry, turbidimetry, tensile tests, stress relaxation, and hydrothermal isometric tension measurements. RESULTS: The density of porcine cornea was measured as p = 1062+/-5 kg/m3, the heat capacity gave c = 3.74+/-0.05 J/gK. The stress-strain relation for corneal strips is represented by a third order approximation where the secant modulus yields about Esec approximately equal to 0.4 MPa for small strains less than 2%. The normalized stress relaxation is described by an exponential fit over time. The denaturation process of cornea is characterized by specific temperatures which can be related to the change of the mechanical properties. Denaturation kinetics are described according to the model of Arrhenius yielding the activation energy deltaEa = 106 kJ/mol and the phase transition entropy deltaS = 39 J/(mol x K). CONCLUSIONS: The established set of parameters characterizes the porcine cornea in a reliable way that creates a basis for corneal models. It furthermore gives direct hints of how to treat cornea in certain refractive techniques.}, keywords = {Animals} } |
J.
Rögener,
J.
Roider, and
C. P.
Lin,
Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen, Lasers Surg Med , vol. 27(5), pp. 451-64, 2000.
Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen, Lasers Surg Med , vol. 27(5), pp. 451-64, 2000.
File: | 227934019_Origin_of_retinal_pigment_epithelium_cell_damage_by_pulsed_laser_irradiance_in_the_nanosecond_to_microsecond_time_regimen |
Bibtex: | @article{Brinkmann2000-1, author = {Brinkmann, R. and Huttmann, G. and Rogener, J. and Roider, J. and Birngruber, R. and Lin, C. P.}, title = {Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen}, journal = {Lasers Surg Med}, volume = {27(5)}, Year = { 2000}, url = { https://www.researchgate.net/publication/227934019_Origin_of_retinal_pigment_epithelium_cell_damage_by_pulsed_laser_irradiance_in_the_nanosecond_to_microsecond_time_regimen}, pages = {451-64}, note = {0196-8092 (Print) In Vitro Journal Article Research Support, Non-U.S. Gov't}, abstract = {BACKGROUND AND OBJECTIVE: Selective photodamage of the retinal pigment epithelium (RPE) is a new technique to treat a variety of retinal diseases without causing adverse effects to surrounding tissues such as the neural retina including the photoreceptors and the choroid. In this study, the mechanism of cell damage after laser irradiation was investigated. STUDY DESIGN/MATERIALS AND METHODS: Single porcine RPE-melanosomes and RPE cells were irradiated with a Nd:YLF laser (wavelength lambda = 527 nm, adjustable pulse duration tau = 250 nsec-3 microsec) and a Nd:YAG laser (lambda = 532 nm, tau = 8 nsec). Fast flash photography was applied to observe vaporization at melanosomes in suspension. A fluorescence viability assay was used to probe the cells vitality. RESULTS: The threshold radiant exposures for vaporization around individual melanosomes and for ED50 cell damage are similar at 8-nsec pulse duration. Both thresholds increase with pulse duration; however, the ED50 cell damage radiant exposure is 40% lower at 3 microsec. Temperature calculations to model the onset of vaporization around the melanosomes are in good agreement with the experimental results when assuming a surface temperature of 150 degrees C to initiate vaporization and a homogeneous melanosome absorption coefficient of 8,000 cm(-1). Increasing the number of pulses delivered to RPE cells at a repetition rate of 500 Hz, the ED50 value } } |
Kester
Nahen,
Werner
Eisenbeiß, and
Alfred
Vogel,
Akustische Online-Kontrolle der Er: YAG Laserablation verbrannter Haut, Biomedizinische Technik/Biomedical Engineering , vol. 45, no. s1, pp. 300-301, 2000.
Akustische Online-Kontrolle der Er: YAG Laserablation verbrannter Haut, Biomedizinische Technik/Biomedical Engineering , vol. 45, no. s1, pp. 300-301, 2000.
H.
Hoerauf,
R. S.
Gordes,
C.
Scholz,
C.
Wirbelauer,
P.
Koch,
R.
Engelhardt,
J.
Winkler, and
H.
Laqua,
First experimental and clinical results with transscleral optical coherence tomography, Ophthalmic Surg Lasers , vol. 31, no. 3, pp. 218-22, 2000.
First experimental and clinical results with transscleral optical coherence tomography, Ophthalmic Surg Lasers , vol. 31, no. 3, pp. 218-22, 2000.
U.
Schmidt-Erfurth,
S.
Teschner,
J.
Noack, and
Reginald
Birngruber,
Confocal laser scanning fluorescence topography: a new method for three-dimensional functional imaging of vascular structures, Graefes Archive for Clinical and Experimental Ophthalmology , vol. 238, no. 7, pp. 559-565, 2000.
Confocal laser scanning fluorescence topography: a new method for three-dimensional functional imaging of vascular structures, Graefes Archive for Clinical and Experimental Ophthalmology , vol. 238, no. 7, pp. 559-565, 2000.
DOI: | DOI 10.1007/s004179900059 |
File: | WOS:000088596000003 |
Bibtex: | @article{Birngruber2000, author = {Birngruber, R. and Schmidt-Erfurth, U. and Teschner, S. and Noack, J.}, title = {Confocal laser scanning fluorescence topography: a new method for three-dimensional functional imaging of vascular structures}, journal = {Graefes Archive for Clinical and Experimental Ophthalmology}, volume = {238}, number = {7}, pages = {559-565}, note = {341NG Times Cited:10 Cited References Count:16}, abstract = {Three-dimensional topography of perfused vascular structures is possible via confocal laser scanning of intravascular fluorescence. The lateral resolution is given by the spot size of the scanning laser beam (optimally 10 mu m at the retina). The axial resolution, however, depends on the accuracy of detection of the surface of the fluorescent structure, which is typically one order of magnitude higher (30 mu m at the retina) than the confocal resolution. The vascular structure is stained with an appropriate fluorescent dye prior to the investigation using standard systemic dye injection. Confocal scanning of the fluorescence in planes of different depths within the vascular structure under investigation leads to a three-dimensional data set. Signal processing in eludes passive eye tracking, lateral averaging and axial determination of the surface of the fluorescent structure. The potential of this new technique is demonstrated by showing the topography of physiological vessel structures as well as of selected vascular diseases such as cone dystrophy, RPE detachment, choroidal haemangioma and retinal laser coagulation. Confocal laser angioscopic fluorescence topography (CLAFT) measures the three-dimensional surface structure of functional (perfused) vasculature and surrounding leakage. CLAFT may help to diagnose and quantify status and time course of vascular diseases.}, keywords = {in-vivo ophthalmoscope therapy}, ISSN = {0721-832X}, DOI = {DOI 10.1007/s004179900059}, url = {<Go to ISI>://WOS:000088596000003}, year = {2000}, type = {Journal Article} } |
C.
Wirbelauer,
C.
Scholz,
H.
Hoerauf,
R.
Engelhardt, and
H.
Laqua,
Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy, Am J Ophthalmol , vol. 130, no. 6, pp. 693-9, 2000.
Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy, Am J Ophthalmol , vol. 130, no. 6, pp. 693-9, 2000.
File: | S0002939400006024 |
Bibtex: | @article{Wirbelauer, author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Engelhardt, R. and Birngruber, R. and Laqua, H.}, title = {Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy}, journal = {Am J Ophthalmol}, volume = {130}, number = {6}, pages = {693-9}, year ={ 2000}, url = { https://www.sciencedirect.com/science/article/abs/pii/S0002939400006024}, note = {0002-9394 (Print) Journal Article}, abstract = {PURPOSE: To investigate the representation of the corneal structure with optical coherence tomography before and immediately after excimer laser photorefractive keratectomy. METHODS: Twenty-four eyes of 24 patients with myopia and myopic astigmatism were prospectively studied. The corneal thickness and the corneal profile were assessed with slit-lamp-adapted optical coherence tomography preoperatively and immediately after excimer laser photorefractive keratectomy. RESULTS: The attempted mean spherical equivalent of the refractive corrections was -6.7 +/- 3.6 (mean +/- SD) diopters with a mean calculated stromal ablation depth of 91 +/- 38 microm. The corneal optical coherence tomography was reproducible in all patients, demonstrating a mean decrease of central corneal thickness after epithelial debridement and excimer laser photorefractive keratectomy of 118 +/- 45 microm. The comparison of the calculated stromal ablation depth and the corneal thickness changes determined by corneal optical coherence tomography revealed a significant linear relationship with a correlation coefficient of 0.88 (P <.001). The flattening of the corneal curvature was confirmed in all patients with the optical coherence tomography system and correlated with the attempted refractive correction (r =.82, P <.001). CONCLUSIONS: The slit-lamp-adapted optical coherence tomography system presented in this study allowed noncontact, cross-sectional, and high-resolution imaging of the corneal configuration. This initial clinical evaluation demonstrated that corneal optical coherence tomography could be a promising diagnostic modality to monitor corneal changes of thickness and curvature before and after excimer laser photorefractive keratectomy.}, keywords = {Adult Astigmatism/*diagnosis/surgery Cornea/*pathology/surgery *Diagnostic Techniques, Ophthalmological Female Humans Interferometry *Keratectomy, Photorefractive, Excimer Laser Male Middle Aged Myopia/*diagnosis/surgery Prospective Studies Refraction, Ocular Reproducibility of Results Sound } } |
C.
Wirbelauer,
N.
Koop,
A.
Tuengler,
G.
Geerling, and
H.
Laqua,
Corneal endothelial cell damage after experimental diode laser thermal keratoplasty, J Refract Surg , vol. 16, no. 3, pp. 323-9, 2000.
Corneal endothelial cell damage after experimental diode laser thermal keratoplasty, J Refract Surg , vol. 16, no. 3, pp. 323-9, 2000.
File: | display.uri |
Bibtex: | @article{Wirbelauer2000, author = {Wirbelauer, C. and Koop, N. and Tuengler, A. and Geerling, G. and Birngruber, R. and Laqua, H. and Brinkmann, R.}, title = {Corneal endothelial cell damage after experimental diode laser thermal keratoplasty}, journal = {J Refract Surg}, volume = {16}, number = {3}, url = {https://www.scopus.com/record/display.uri?eid=2-s2.0-0034040252&origin=inward&txGid=6e537773e3e3f14b9b83f939c4a9ce7d}, pages = {323-9}, note = {Wirbelauer, C Koop, N Tuengler, A Geerling, G Birngruber, R Laqua, H Brinkmann, R Journal Article United States J Refract Surg. 2000 May-Jun;16(3):323-9.}, abstract = {PURPOSE: To evaluate the safety of diode laser thermal keratoplasty (LTK) with respect to corneal endothelial cell damage. METHODS: In an in vitro animal model system, porcine eyes were irradiated with a continuously emitting laser diode at wavelengths (lambda) of 1.85 or 1.87 microm, corresponding to an absorption coefficient (micro(a)) of 1.1 or 2.0 mm(-1). Different irradiation and application parameters were tested serially. To determine the temperature threshold for endothelial damage, corneal buttons were analyzed separately in a waterbath experiment. The endothelial damage was assessed after trypan blue and alizarin red supravital staining under light microscopy. RESULTS: The thresholds for the 50% probability of thermal damage (ED50) were determined at corneal temperatures of 65 degrees C for a 10-second water-bath immersion, and 59 degrees C for 60 seconds. Coagulations that reached the deeper stromal layers revealed severe endothelial cellular alterations and areas of exposed Descemet's membrane. The thermally induced changes were dependent on laser power and the absorption coefficient (wavelength). Mean diameter of total endothelial cell damage was 245 +/- 154 microm (range, 0 to 594 microm) for an absorption coefficient of 1.1 mm(-1). The maximal lateral extent of endothelial cell damage induced by the laser exposure was 594 microm in diameter. Increasing the absorption coefficient decreased the penetration depth of the laser irradiation, creating a greater temperature rise within the corneal stroma and significantly less endothelial damage (P < .01), when the same laser power was applied. The calculated total area of damage for the paracentral human corneal endothelium ranged from 1.8% to 13.6%. CONCLUSION: Data obtained in this in vitro study were transferred to an endothelial cell damage nomogram, demonstrating that appropriate parameter improvements can minimize the adverse effects to the corneal endothelium. However, model adjustment to the human cornea indicates the potential for endothelial cell damage after diode laser thermal keratoplasty, and should be considered when performing this elective procedure.}, keywords = {Animals Anthraquinones Cell Count Cell Survival Corneal Diseases/*etiology/pathology Corneal Stroma/*surgery Endothelium, Corneal/*pathology Laser Coagulation/*adverse effects/methods Necrosis Safety Swine Trypan Blue}, ISSN = {1081-597X (Print) 1081-597x}, year = {2000}, type = {Journal Article} } |
C.
Meyer,
H.
Hoerauf,
U.
Schmidt-Erfurth,
J.
Roider,
C.
Scholz, and
H.
Laqua,
Correlation of morphologic changes between optical coherence tomography and topographic angiography in a case of gyrate atrophy, Ophthalmologe , vol. 97, no. 1, pp. 41-46, 2000.
Correlation of morphologic changes between optical coherence tomography and topographic angiography in a case of gyrate atrophy, Ophthalmologe , vol. 97, no. 1, pp. 41-46, 2000.
DOI: | DOI 10.1007/s003470050009 |
File: | WOS:000085269900009 |
Bibtex: | @article{Meyer2000, author = {Meyer, C. and Hoerauf, H. and Schmidt-Erfurth, U. and Roider, J. and Scholz, C. and Laqua, H. and Birngruber, R.}, title = {Correlation of morphologic changes between optical coherence tomography and topographic angiography in a case of gyrate atrophy}, journal = {Ophthalmologe}, volume = {97}, number = {1}, pages = {41-46}, note = {283HG Times Cited:5 Cited References Count:10}, abstract = {Purpose:To characterize ultrastrructual changes in atrophic disease of the retina, RPE and choroid as seen with gyrate atrophy using two new diagnostic modalities, optical coherence tomography (OCT) and topographic angiography. Patient and method: OCT images were taken in a patient with pericentral choroidal atrophy using a slit-lamp-adapted OCT system. Ophthalmoscopy, conventional and topographic angiographic findings were correlated to the reflectivity changes as seen an OCT. Results:Areas of chorioretinal atrophy correlated with a loss of reflectivity in the RPE-choriocapillaris complex on OCT. Additionally OCT identified a thinning of the nerve fiber layer. Topographic angiography demonstrated an extensive defect, seen as an area of depression, consistent with a loss of choriocapillaris and larger-sized choroidal vessels. In contrast to conventional angiography, central islands were not found to demonstrate structural intensity, while the midperipheral surrounding area was clearly elevated to physiological levels. Conclusion: OCT and topographic angiography provide in vivo insight into morphologic changes within neurosensory retina and choroid caused by pericentral choroidal atrophy.}, keywords = {optical coherence tomography topographic aniography pericentral choroidal atrophy ornithine}, ISSN = {0941-293X}, DOI = {DOI 10.1007/s003470050009}, url = {<Go to ISI>://WOS:000085269900009}, year = {2000}, type = {Journal Article} } |
S.
Teschner,
J.
Noack, and
U.
Schmidt-Erfurth,
Documentation of perfusion and leakage characteristics in age-related macular degeneration by dynamic topographic angiography, Investigative Ophthalmology & Visual Science , vol. 41, no. 4, pp. S170-S170, 2000.
Documentation of perfusion and leakage characteristics in age-related macular degeneration by dynamic topographic angiography, Investigative Ophthalmology & Visual Science , vol. 41, no. 4, pp. S170-S170, 2000.
B.
Radt,
C.
Flamm,
J.
Kampmeier, and
N.
Koop,
Influence of temperature and time on thermally induced forces in corneal collagen and the effect on laser thermokeratoplasty, J Cataract Refract Surg , vol. 26(5), no. 5, pp. 744-54, 2000.
Influence of temperature and time on thermally induced forces in corneal collagen and the effect on laser thermokeratoplasty, J Cataract Refract Surg , vol. 26(5), no. 5, pp. 744-54, 2000.
File: | query.fcgi |
Bibtex: | @article{Brinkmann2000, author = {Brinkmann, R. and Radt, B. and Flamm, C. and Kampmeier, J. and Koop, N. and Birngruber, R.}, title = {Influence of temperature and time on thermally induced forces in corneal collagen and the effect on laser thermokeratoplasty}, journal = {J Cataract Refract Surg}, volume = {26(5)}, Year = {2000}, pages = {744-54}, note = {0886-3350 (Print) Journal Article Research Support, Non-U.S. Gov't}, abstract = {PURPOSE: To investigate thermomechanical aspects of corneal collagen denaturation as a function of temperature and time and the effect of the induced forces on refractive changes with laser thermokeratoplasty (LTK). SETTING: Medical Laser Center Lubeck, Lubeck, Germany. METHODS: In a material-test setup, porcine corneal strips were denatured in paraffin oil at various constant temperatures for 10 and 500 seconds, and the temporal course of the contractive forces was studied under isometric conditions. Typical LTK lesions were performed in porcine eyes in vitro with a continuous-wave infrared laser diode at a wavelength of 1.87 microm for 10 and 60 seconds. The laser power was chosen to achieve comparable denatured volumes at both irradiation times. The refractive changes were measured and analyzed by histologic evaluations and temperature calculations. RESULTS: The time course of the induced forces was characterized by a maximal force, which increased almost linearly with temperature, and a residual lower force. After 500 seconds of heating, the highest force was achieved with a temperature of 75 degrees C. With a limited heating period of only 10 seconds, the forces steadily increased with temperature over the entire observation period. Laser thermokeratoplasty produced less refractive change after 10 seconds of irradiation than after 60 seconds, although the laser power was 25% higher in the short heating period. Polarization light microscopy of LTK lesions revealed different stages of thermal damage. CONCLUSION: The course of the contractive forces during and after heating is a complicated function of the spatial time/temperature profile. Laser thermokeratoplasty lesions produced with 2 irradiation times showed different stages of denaturation and induced refractive change.}, keywords = {Animals Body Temperature Collagen/*metabolism Cornea/metabolism/pathology/*surgery *Laser Coagulation Microscopy, Polarization Protein Denaturation Swine Time Factors}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10831907}, year = {2000}, type = {Journal Article} } |
H.
Hoerauf,
R.
Gordes,
C.
Scholz,
P.
Koch,
R.
Engelhardt,
C.
Wirbelauer, and
H.
Laqua,
First experimental and clinical results of transscleral OCT, Investigative Ophthalmology & Visual Science , vol. 41, no. 4, pp. S786-S786, 2000.
First experimental and clinical results of transscleral OCT, Investigative Ophthalmology & Visual Science , vol. 41, no. 4, pp. S786-S786, 2000.
B. Radt,
Laserinduzierte Mikro- und Nanoeffekte - Von der selektiven Thermolyse zu molekularen Nanoeffekten, LaserOpto , vol. 32, pp. 47-55, 2000.
Laserinduzierte Mikro- und Nanoeffekte - Von der selektiven Thermolyse zu molekularen Nanoeffekten, LaserOpto , vol. 32, pp. 47-55, 2000.
Laserinduzierte thermische Gewebseffekte mit mikroskopischer und makromolekularer Präzision, Z Med Phys , vol. 10, pp. 169-174, 2000.
G.
Schule,
J.
Roider, and
C.
Wirbelauer,
Optoacoustic measurements during µs-irradiation of the retinal pigment epithelium, Proc. SPIE , vol. 3914A, 2000.
Optoacoustic measurements during µs-irradiation of the retinal pigment epithelium, Proc. SPIE , vol. 3914A, 2000.
J. Roider,
Patenting medical procedures, Arch Ophthalmol , vol. 118, no. 8, pp. 1140, 2000.
Patenting medical procedures, Arch Ophthalmol , vol. 118, no. 8, pp. 1140, 2000.
File: | query.fcgi |
Bibtex: | @article{Roider2000, author = {Roider, J. and Birngruber, R.}, title = {Patenting medical procedures}, journal = {Arch Ophthalmol}, volume = {118}, number = {8}, pages = {1140}, note = {0003-9950 (Print) Journal article}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10922219}, year = {2000}, type = {Journal Article} } |
J. Roider,
Patenting medical procedures - Reply, Archives of Ophthalmology , vol. 118, no. 8, pp. 1140-1140, 2000.
Patenting medical procedures - Reply, Archives of Ophthalmology , vol. 118, no. 8, pp. 1140-1140, 2000.
Reginald
Birngruber,
U.
Schmidt-Erfurth, and
T.
Hasan,
Photodynamische Therapie der altersbedingten Makuladegeneration - Nichtthermische Laserbestrahlung aktiviert einen hochselektiven Photosensibilisator, LaserOpto , vol. 32, pp. 66-70, 2000.
Photodynamische Therapie der altersbedingten Makuladegeneration - Nichtthermische Laserbestrahlung aktiviert einen hochselektiven Photosensibilisator, LaserOpto , vol. 32, pp. 66-70, 2000.
H.
Hoerauf,
C.
Wirbelauer,
C.
Scholz,
R.
Engelhardt,
P.
Koch, and
H.
Laqua,
Slit-lamp-adapted optical coherence tomography of the anterior segment, Graefes Archive for Clinical and Experimental Ophthalmology , vol. 238, no. 1, pp. 8-18, 2000.
Slit-lamp-adapted optical coherence tomography of the anterior segment, Graefes Archive for Clinical and Experimental Ophthalmology , vol. 238, no. 1, pp. 8-18, 2000.
DOI: | DOI 10.1007/s004170050002 |
File: | WOS:000085205300002 |
Bibtex: | @article{Hoerauf2000, author = {Hoerauf, H. and Wirbelauer, C. and Scholz, C. and Engelhardt, R. and Koch, P. and Laqua, H. and Birngruber, R.}, title = {Slit-lamp-adapted optical coherence tomography of the anterior segment}, journal = {Graefes Archive for Clinical and Experimental Ophthalmology}, volume = {238}, number = {1}, pages = {8-18}, note = {282FC Times Cited:77 Cited References Count:19}, abstract = {Purpose: To evaluate the diagnostic potential of a slit-lamp-adapted optical coherence tomography (OCT) system as an in vivo imaging device for routine clinical examination of the anterior segment of the eve. Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a slit-lamp-adapted OCT system using 100-200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue. Results: The slit-lamp-adapted OCT system allowed direct biomicroscopic imaging of the measured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epithelium could be visualized with high accuracy, Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possible. Complete demonstration of the chamber angle was difficult clue to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris. Conclusions: Slit-lamp-adapted OCT is a diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular structures.}, keywords = {in-vivo nerve eye}, ISSN = {0721-832X}, DOI = {DOI 10.1007/s004170050002}, url = {<Go to ISI>://WOS:000085205300002}, year = {2000}, type = {Journal Article} } |
J.
Roider,
C.
Wirbelauer, and
H.
Laqua,
Subthreshold (retinal pigment epithelium) photocoagulation in macular diseases: a pilot study, Br J Ophthalmol , vol. 84, no. 1, pp. 40-7, 2000.
Subthreshold (retinal pigment epithelium) photocoagulation in macular diseases: a pilot study, Br J Ophthalmol , vol. 84, no. 1, pp. 40-7, 2000.
M.
Sickenberg,
U.
Schmidt-Erfurth,
J. W.
Miller,
C. J.
Pournaras,
L.
Zografos,
B.
Piguet,
G.
Donati,
H.
Laqua,
I.
Barbazetto,
E. S.
Gragoudas,
A. M.
Lane,
H.
Bergh,
H. A.
Strong,
U.
Manjuris,
T.
Gray,
M.
Fsadni,
N. M.
Bressler, and
Reginald
Birngruber,
A preliminary study of photodynamic therapy using verteporfin for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes, Arch Ophthalmol , vol. 118, no. 3, pp. 327-36, 2000.
A preliminary study of photodynamic therapy using verteporfin for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes, Arch Ophthalmol , vol. 118, no. 3, pp. 327-36, 2000.
File: | 412940 |
Bibtex: | @article{Sickenberg, author = {Sickenberg, M. and Schmidt-Erfurth, U. and Miller, J. W. and Pournaras, C. J. and Zografos, L. and Piguet, B. and Donati, G. and Laqua, H. and Barbazetto, I. and Gragoudas, E. S. and Lane, A. M. and Birngruber, R. and van den Bergh, H. and Strong, H. A. and Manjuris, U. and Gray, T. and Fsadni, M. and Bressler, N. M.}, title = {A preliminary study of photodynamic therapy using verteporfin for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes}, journal = {Arch Ophthalmol}, volume = {118}, number = {3}, pages = {327-36}, year = { 2000}, url = { https://jamanetwork.com/journals/jamaophthalmology/fullarticle/412940}, note = {0003-9950 (Print) Case Reports Clinical Trial Clinical Trial, Phase I Clinical Trial, Phase II Journal Article Multicenter Study Research Support, Non-U.S. Gov't}, abstract = {OBJECTIVE: To evaluate short-term safety and the effects on visual acuity and fluorescein angiography of single or multiple sessions of photodynamic therapy with verteporfin for choroidal neovascularization (CNV) not related to age-related macular degeneration (AMD), including pathologic myopia, the ocular histoplasmosis syndrome, angioid streaks, and idiopathic causes. DESIGN: A nonrandomized, multicenter, open-label, dose-escalation phase 1 and 2 clinical trial. SETTING: Four ophthalmic centers in Europe and North America providing retinal care. PARTICIPANTS: Thirteen patients with subfoveal CNV due to pathologic myopia, the ocular histoplasmosis syndrome, angioid streaks, or idiopathic causes. METHODS: Standardized protocol refraction, visual acuity testing, ophthalmic examinations, color photographs, and fluorescein angiograms were used to evaluate the results of photodynamic therapy treatments with verteporfin. Follow-up ranged from 12 weeks for patients who were treated once to 43 weeks for patients who were treated up to 4 times. RESULTS: Verteporfin therapy was well tolerated in patients with CNV not related to AMD. No deterioration in visual acuity was observed; most patients gained at least 1 line of vision. Reduction in the size of leakage area from classic CNV was noted in all patients as early as 1 week after verteporfin therapy, with complete absence of leakage from classic CNV in almost half of the patients. Improvement in visual acuity after verteporfin therapy was greatest (+6, +8, and +9 lines) in 3 patients with relatively poor initial visual acuity (between 20/200 and 20/800). Up to 4 treatments were found to have short-term safety even with retreatment intervals as short as 4 weeks. CONCLUSIONS: Treatment of CNV not related to AMD with verteporfin therapy achieves short-term cessation of fluorescein leakage from CNV in a small number of patients without loss of vision. Further randomized clinical trials including a larger number of patients are under way to confirm whether verteporfin therapy is beneficial for subfoveal CNV not related to AMD.}, keywords = {Adult} } |
1999
J.
Rögener,
C.P.
Lin, and
J.
Roider,
Selective RPE-Photodestruction: Mechanism of Cell Damage by pulsed laser irradiance in the ns to µs time regime, Proc. SPIE , vol. 3601, pp. 59-65, 1999.
Selective RPE-Photodestruction: Mechanism of Cell Damage by pulsed laser irradiance in the ns to µs time regime, Proc. SPIE , vol. 3601, pp. 59-65, 1999.
On the Possibility of High-Precision Photothermal Microeffects and the Measurement of Fast thermal Denaturation of Proteins., IEEE J Quant Electr , vol. 5, no. 4, pp. 954-962, 1999.
J. W.
Miller,
U.
Schmidt-Erfurth,
M.
Sickenberg,
C. J.
Pournaras,
H.
Laqua,
I.
Barbazetto,
L.
Zografos,
B.
Piguet,
G.
Donati,
A. M.
Lane,
H.
Berg,
H. A.
Strong,
U.
Manjuris,
T.
Gray,
M.
Fsadni,
N. M.
Bressler, and
E. S.
Gragoudas,
Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration - Results of a single treatment in a phase 1 and 2 study, Archives of Ophthalmology , vol. 117, no. 9, pp. 1161-1173, 1999.
Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration - Results of a single treatment in a phase 1 and 2 study, Archives of Ophthalmology , vol. 117, no. 9, pp. 1161-1173, 1999.
J.
Noack, and
Alfred
Vogel,
Laser-induced plasma formation in water at nanosecond to femtosecond time scales: calculation of thresholds, absorption coefficients, and energy density, Quantum Electronics, IEEE Journal of , vol. 35, no. 8, pp. 1156-1167, 1999.
Laser-induced plasma formation in water at nanosecond to femtosecond time scales: calculation of thresholds, absorption coefficients, and energy density, Quantum Electronics, IEEE Journal of , vol. 35, no. 8, pp. 1156-1167, 1999.
D.
Theisen, and
T.
Brendel,
Single-pulse 30-J holmium laser for myocardial revascularization - A study on ablation dynamics in comparison to CO2 laser-TMR, Ieee Journal of Selected Topics in Quantum Electronics , vol. 5, no. 4, pp. 969-980, 1999.
Single-pulse 30-J holmium laser for myocardial revascularization - A study on ablation dynamics in comparison to CO2 laser-TMR, Ieee Journal of Selected Topics in Quantum Electronics , vol. 5, no. 4, pp. 969-980, 1999.
DOI: | Doi 10.1109/2944.796319 |
File: | WOS:000083257800015 |
Bibtex: | @article{Brinkmann1999, author = {Brinkmann, R. and Theisen, D. and Brendel, T. and Birngruber, R.}, title = {Single-pulse 30-J holmium laser for myocardial revascularization - A study on ablation dynamics in comparison to CO2 laser-TMR}, journal = {Ieee Journal of Selected Topics in Quantum Electronics}, volume = {5}, number = {4}, pages = {969-980}, note = {248CM Times Cited:9 Cited References Count:40}, abstract = {Endocardial laser revascularization (ELR) is a new technique to treat coronary heart disease in a percutaneous, minimally invasive approach. A holmium laser (lambda = 2.12 mu m) was developed to emit pulse energies of up to 30 J in order to ablate the desired channels in a single laser pulse. The energy was transmitted by multimode flexible optical waveguides as required for ELR, Ablation dynamics were investigated in two model systems, water serving as blood model and polyacrylamide (PAA) as a transparent tissue phantom. Measurements were undertaken using pulse energies of 12 J at pulse durations of 2.2 and 8 ms with a beam diameter of 1 mm, For comparison with the clinically established method of transmyocardial revascularization (TMR), ablations were also investigated with a standard 800 W TMR CO2 laser. The dynamics were recorded with a drum camera and stroboscope illumination providing a high framing rate of a single ablation process. Tissue ablation was quantified with the holmium laser in vitro on porcine heart tissue using pulse energies of up to 20 J, Tissue morphology was evaluated using polarization light microscopy to determine thermal and mechanical collateral damage zones. Oscillating vapor bubble channels were found in water and PAA with all laser systems and parameters used. Quasi-static vapor bubbles are observed in water in the millisecond time range using the holmium laser. CO2 laser radiation performed deeper channels in PAA than holmium laser pulses using the same radiant exposure. Channel depths of up to 10 mm were achieved with the holmium laser in myocardial tissue with pulse energies of 17 J, Thermal damage zones of about 150 mu m for the CO2 and 500 mu m for the holmium laser were found. The orientation of myocardial fibrils significantly influences the shape of the ablated cavities and the thermo-mechanical collateral damage zones. In conclusion, the results are very encouraging and demonstrate the potential of a catheter-based minimal invasive procedure for heart reperfusion using single high energy laser pulses.}, keywords = {ablation dynamics co2 laser elr fast flash photography heart revascularization holmium laser polyacrylamide tmlr tmr transmyocardial revascularization tissue ablation channels generation duration water blood}, ISSN = {1077-260X}, DOI = {Doi 10.1109/2944.796319}, url = {<Go to ISI>://WOS:000083257800015}, year = {1999}, type = {Journal Article} } |
J.
Roider,
C.
Wirbelauer, and
H.
Laqua,
Retinal sparing by selective retinal pigment epithelial photocoagulation, Arch Ophthalmol , vol. 117, no. 8, pp. 1028-34, 1999.
Retinal sparing by selective retinal pigment epithelial photocoagulation, Arch Ophthalmol , vol. 117, no. 8, pp. 1028-34, 1999.
File: | query.fcgi |
Bibtex: | @article{Roider1999, author = {Roider, J. and Brinkmann, R. and Wirbelauer, C. and Laqua, H. and Birngruber, R.}, title = {Retinal sparing by selective retinal pigment epithelial photocoagulation}, journal = {Arch Ophthalmol}, volume = {117}, number = {8}, pages = {1028-34}, note = {0003-9950 (Print) Journal Article}, abstract = {OBJECTIVE: To investigate whether photocoagulation of the retinal pigment epithelium is possible with sparing of the photoreceptors. METHODS: Mild laser effects of a neodymium:yttrium-lithium-fluoride (Nd:YLF) laser (527 nm) were applied to 17 patients. To establish the necessary energy, test exposures were performed to the lower macula (laser variables: 1.7 microseconds, 100 and 500 pulses applied in a train at 500 Hz, 20-130 microJ, 160 microm). Of 179 test lesions, 73 were followed up at various time intervals up to 1 year by performing microperimetry directly on top of the laser lesions. RESULTS: All of the test lesions were at the threshold of retinal pigment epithelial disruption, and none of the laser effects were visible by ophthalmoscopy during photocoagulation; they were detectable only by fluorescein angiography. After exposure with 500 pulses, retinal defects were detected in up to 73% of the patients (100 microJ) after the first day. Most of these defects were no longer detectable after 3 months. After exposure with 100 pulses, no defects could be detected with 70 and 100 microJ after 1 day. The absence of microscotomas in the follow-up period suggests that retinal damage was minimal or, if it occurred, was functionally repaired. CONCLUSION: By choosing proper energy and number of pulses, it is possible to produce retinal pigment epithelial effects with no subsequent retinal damage detectable by microperimetry.}, keywords = {Adult Eye Injuries/physiopathology/*prevention & control Female Fluorescein Angiography Follow-Up Studies Fundus Oculi Humans *Laser Coagulation/methods Male Middle Aged Ophthalmoscopy Perimetry Pigment Epithelium of Eye/physiopathology/*surgery Retina/injuries/*physiopathology Retinal Diseases/physiopathology/*surgery Visual Acuity}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10448745}, year = {1999}, type = {Journal Article} } |
U.
Schmidt-Erfurth,
J. W.
Miller,
M.
Sickenberg,
H.
Laqua,
I.
Barbazetto,
E. S.
Gragoudas,
L.
Zografos,
B.
Piguet,
C. J.
Pournaras,
G.
Donati,
A. M.
Lane,
H.
Berg,
H. A.
Strong,
U.
Manjuris,
T.
Gray,
M.
Fsadni, and
N. M.
Bressler,
Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of retreatments in a phase 1 and 2 study, Arch Ophthalmol , vol. 117, no. 9, pp. 1177-87, 1999.
Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration: results of retreatments in a phase 1 and 2 study, Arch Ophthalmol , vol. 117, no. 9, pp. 1177-87, 1999.
J.
Roider,
C.
Wirbelauer, and
H.
Laqua,
Variability of RPE reaction in two cases after selective RPE laser effects in prophylactic treatment of drusen, Graefes Arch Clin Exp Ophthalmol , vol. 237, no. 1, pp. 45-50, 1999.
Variability of RPE reaction in two cases after selective RPE laser effects in prophylactic treatment of drusen, Graefes Arch Clin Exp Ophthalmol , vol. 237, no. 1, pp. 45-50, 1999.
File: | query.fcgi |
Bibtex: | @article{Roider1999, author = {Roider, J. and Brinkmann, R. and Wirbelauer, C. and Birngruber, R. and Laqua, H.}, title = {Variability of RPE reaction in two cases after selective RPE laser effects in prophylactic treatment of drusen}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {237}, number = {1}, pages = {45-50}, note = {0721-832X (Print) Case Reports Journal Article}, abstract = {BACKGROUND: The value of prophylactic photocoagulation of soft drusen is unclear. Photocoagulation is usually performed by a continuous wave laser. METHODS: We report the cases of two patients with age-related macular degeneration with soft drusen who were treated by selective retinal pigment epithelium (RPE) photocoagulation of a pulsed Nd:YLF (527 nm) laser. Laser parameters were: wavelength 527 nm, number of pulses in a train 500, pulse duration 1.7 microseconds, energy per pulse 70 microJ, spot size 160 microns, repetition rate 500 Hz. RESULTS: Dosimetry performed individually showed that in both patients laser photocoagulation was performed at the threshold of RPE disruption. None of the laser effects was visible during photocoagulation. They were detectable only by fluorescein angiography. Despite identical photocoagulation parameters the RPE reaction was completely different. In the first patient RPE hyperpigmentation was notable at most photocoagulation sites and the drusen had disappeared after 6 months. In the second patient the laser effects were not visible after 6 months by biomicroscopy and the drusen stayed unchanged. CONCLUSION: These findings could reflect different repair mechanisms of the RPE after alteration and could represent a sign of a different viable stage in the life of RPE cells. Close attention should be paid to this phenomenon in the various drusen studies currently under way.}, keywords = {Fluorescein Angiography Fundus Oculi Humans *Laser Coagulation Macular Degeneration/complications Middle Aged Pigment Epithelium of Eye/pathology/*surgery Retinal Drusen/complications/pathology/*surgery Visual Acuity}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9951641}, year = {1999}, type = {Journal Article} } |
Study group TAP,
Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Age-related Macular Degeneration with Verteporfin - One-Year Results of 2 Randomized Clinical Trials - TAP Report 1, Arch Ophthalmol , vol. 117, pp. 1329-1345, 1999.
Photodynamic Therapy of Subfoveal Choroidal Neovascularization in Age-related Macular Degeneration with Verteporfin - One-Year Results of 2 Randomized Clinical Trials - TAP Report 1, Arch Ophthalmol , vol. 117, pp. 1329-1345, 1999.
On the possibility of high-precision photothermal microeffects and the measurement of fast thermal denaturation of proteins, Ieee Journal of Selected Topics in Quantum Electronics , vol. 5, no. 4, pp. 954-962, 1999.
DOI: | Doi 10.1109/2944.796317 |
File: | WOS:000083257800013 |
Bibtex: | @article{Hüttmann1999, author = {Huttmann, G. and Birngruber, R.}, title = {On the possibility of high-precision photothermal microeffects and the measurement of fast thermal denaturation of proteins}, journal = {Ieee Journal of Selected Topics in Quantum Electronics}, volume = {5}, number = {4}, pages = {954-962}, note = {248CM Times Cited:77 Cited References Count:43}, abstract = {The precision of laser-induced effects is often limited by thermal and thermomechanical collateral damage. Adjusting the pulsewidth of the laser to the size of the absorbing structure can at least avoid thermal side effects and facilitates a selective treatment of vessels or pigmented cells. Further extending the precision of thermal effects below cellular dimensions by using nanometer sized particles could open up new fields of applications for lasers in medicine and biology. Calculations show that under irradiation with nano- or picosecond laser pulses gold particles of submicrometer size can easily be heated by several hundred K, High temperatures have to be used for subcellular thermal effects, because heat confinement to such small structures requires the thermal damage to occur in extremely short times. Estimating the denaturation temperature by extrapolating the Arrhenius equation from a time range of minutes and seconds into a time range of nano- and picoseconds leads to temperatures beta;een 370 K-470 K, There is evidence that in aqueous media, due to the surface tension, these temperatures can be generated at the surface of nanometer sized particles without vaporization of the surrounding water, In order to show whether or not an extrapolation of the damage rates over six to nine orders of magnitude gives correct data, a temperature-jump experiment was designed and tested which allows to measure denaturation rates of proteins in the millisecond time range. Denaturation of chymotrypsin was observed within 300 mu s at temperatures below 380 K, The rate constants for the unfolding of chymotrypsin followed the Arrhenius equation up to rates of 3000 s(-1).}, keywords = {laser medicine microeffects protein denaturation thermal effects assisted laser inactivation}, ISSN = {1077-260X}, DOI = {Doi 10.1109/2944.796317}, url = {<Go to ISI>://WOS:000083257800013}, year = {1999}, type = {Journal Article} } |
J.
Roider,
P.
Buesgen,
H.
Hoerauf,
U.
Schmidt-Erfurth, and
H.
Laqua,
Macular injury by a military range finder, Retina-the Journal of Retinal and Vitreous Diseases , vol. 19, no. 6, pp. 531-535, 1999.
Macular injury by a military range finder, Retina-the Journal of Retinal and Vitreous Diseases , vol. 19, no. 6, pp. 531-535, 1999.
DOI: | Doi 10.1097/00006982-199911000-00009 |
File: | WOS:000167042200009 |
Bibtex: | @article{Roider1999, author = {Roider, J. and Buesgen, P. and Hoerauf, H. and Schmidt-Erfurth, U. and Laqua, H. and Birngruber, R.}, title = {Macular injury by a military range finder}, journal = {Retina-the Journal of Retinal and Vitreous Diseases}, volume = {19}, number = {6}, pages = {531-535}, note = {403KZ Times Cited:11 Cited References Count:18}, abstract = {Objective: The authors report the clinical findings of a civilian patient who unintentionally looked into the laser beam of a military range finder. Detailed information on the range finder is given. The objective is to illustrate the potential danger of such devices and to give detailed information on the device, the clinical findings associated with exposure, and the laser-tissue interaction mechanism. Methods: The patient was examined with fluorescein angiography, indocyanine green angiography, microperimetry, and optical coherence tomography, both in the acute stage (2 hours) and 4 weeks later. Fluorescein angiography was performed again 4 months later. A total of 100 mg prednisone tapered over 9 days was prescribed. Additionally, 50 mug tissue plasminogen activator (TPA) and 0.5 mt pure C2F6 were injected in the vitreous. Results: In the acute phase, hemorrhage was located beneath the retina, primarily beneath the retinal pigment epithelium. Retinal defects as seen initially over the subretinal blood were reduced after 4 weeks, but a retinal defect ranging from the lasered site toward the fovea remained. Visual acuity slightly increased from 20/100 to 20/63 after 4 weeks. Indocyanine green angiography showed a large hypofluorescent spot in the macula. Four months after the accident, a classic choroidal neovascularization developed, originating from the lasered site. The technical parameters of the range finder were: Nd:YAG laser (1,064 nm), pulse duration 10 ns, beam divergence 1.5 mrad, energy 10 mJ. Conclusion: A range finder can produce severe macular injury. The primary laser-tissue interaction mechanism seems to be explosive disruption of choroidal tissue. Intravitreal injection of TPA and C2F6 did not show a clear benefit to such laser lesions. A late complication can be secondary choroidal neovascularization.}, keywords = {laser accident range finder nd : yag tissue plasminogen activator choroidal neovascularization retinal injury yag laser neovascularization neodymium}, ISSN = {0275-004X}, DOI = {Doi 10.1097/00006982-199911000-00009}, url = {<Go to ISI>://WOS:000167042200009}, year = {1999}, type = {Journal Article} } |
K.
Nahen, and
Alfred
Vogel,
Investigations on Acoustic On- Line Monitoring of IR Laser Ablation of burned Skin, Laser in Surgery and Medicine , vol. 25, pp. 69-78, 1999.
Investigations on Acoustic On- Line Monitoring of IR Laser Ablation of burned Skin, Laser in Surgery and Medicine , vol. 25, pp. 69-78, 1999.
Josef
Wachtveitl,
Robert
Huber,
Sebastian
Spörlein,
Jacques E.
Moser, and
Michael
Grätzel,
Ultrafast photoinduced electron transfer in coumarin 343 sensitized TiO2-colloidal solution, International Journal of Photoenergy , vol. 1, no. 3, pp. 153-155, 1999.
Ultrafast photoinduced electron transfer in coumarin 343 sensitized TiO2-colloidal solution, International Journal of Photoenergy , vol. 1, no. 3, pp. 153-155, 1999.
DOI: | 10.1155/S1110662X99000264 |
Bibtex: | @Article{HU_1999_Wachtveitl_a, Title = {{Ultrafast photoinduced electron transfer in coumarin 343 sensitized TiO2-colloidal solution}}, Author = {Wachtveitl, Josef and Huber, Robert and Sp\"{o}rlein, Sebastian and Moser, Jacques E and Gr\"{a}tzel, Michael}, Journal = {International Journal of Photoenergy}, Year = {1999}, Number = {3}, Pages = {153--155}, Volume = {1}, keywords = {AG-Huber}, Doi = {10.1155/S1110662X99000264}, ISSN = {1110-662X}, Url = {http://www.hindawi.com/journals/ijp/1999/418298/abs/} } |
Alfred
Vogel,
K.
Nahen,
J.
Thomas, and
B.A.
Rockwell,
Influence of optical aberrations on laser-induced plasma formation in water, and their consequences for intraocular photodisruption, Appl Optics , vol. 38, no. 16, pp. 3636-3643, 1999.
Influence of optical aberrations on laser-induced plasma formation in water, and their consequences for intraocular photodisruption, Appl Optics , vol. 38, no. 16, pp. 3636-3643, 1999.
Alfred
Vogel,
J.
Noack,
K.
Nahen,
D.
Theisen,
U.
Parlitz,
D.X.
Hammer,
G. D.
Noojin, and
B.A.
Rockwell,
Energy balance of optical breakdown in water at nanosecond to femtosecond time scales, Appl Phys B , vol. 68, no. 271-280, 1999.
Energy balance of optical breakdown in water at nanosecond to femtosecond time scales, Appl Phys B , vol. 68, no. 271-280, 1999.
Endokardiale Laser Revaskularisation des Myokards mittels 20 J Einzelpuls Holmium Laserstrahlung, Laser-Medizin: eine interdisziplinäre Zeitschrift ; Praxis, Klinik, Forschung , vol. 14, no. 4, pp. 125 - 128, 1999.
DOI: | https://doi.org/10.1016/S0938-765X(99)80019-4 |
Bibtex: | @article{Brinkmann-1999, author = {Theisen, D.;Brendel, T.;Birngrub.R and Brinkman, R}, title = {Endokardiale Laser Revaskularisation des Myokards mittels 20 J Einzelpuls Holmium Laserstrahlung}, journal = {Laser-Medizin: eine interdisziplinäre Zeitschrift ; Praxis, Klinik, Forschung}, volume = {14}, number = {4}, pages = {125 - 128}, ISSN = {0938-765X}, DOI = {https://doi.org/10.1016/S0938-765X(99)80019-4}, year = {1999}, type = {Journal Article} } |
G.
Geerling,
N.
Koop,
A.
Tungler,
C.
Wirbelauer, and
H.
Laqua,
Diode laser thermokeratoplasty. Initial clinical experiences, Ophthalmologe , vol. 96, no. 5, pp. 306-11, 1999.
Diode laser thermokeratoplasty. Initial clinical experiences, Ophthalmologe , vol. 96, no. 5, pp. 306-11, 1999.
G.
Geerling,
N.
Koop,
A.
Tungler,
C.
Wirbelauer, and
H.
Laqua,
Continuous-wave diode laser thermokeratoplasty: first clinical experience in blind human eyes, J Cataract Refract Surg , vol. 25, no. 1, pp. 32-40, 1999.
Continuous-wave diode laser thermokeratoplasty: first clinical experience in blind human eyes, J Cataract Refract Surg , vol. 25, no. 1, pp. 32-40, 1999.
File: | query.fcgi |
Bibtex: | @article{Geerling1999, author = {Geerling, G. and Koop, N. and Brinkmann, R. and Tungler, A. and Wirbelauer, C. and Birngruber, R. and Laqua, H.}, title = {Continuous-wave diode laser thermokeratoplasty: first clinical experience in blind human eyes}, journal = {J Cataract Refract Surg}, volume = {25}, number = {1}, pages = {32-40}, note = {0886-3350 (Print) Clinical Trial Journal Article Research Support, Non-U.S. Gov't}, abstract = {PURPOSE: To evaluate the safety and stability of laser thermokeratoplasty (LTK) with a continuous-wave diode laser in blind human eyes and to optimize parameters for a study in sighted eyes. SETTING: Department of Ophthalmology, Medical University Lubeck, Germany. METHODS: A continuous-wave diode laser was set to emit radiation with a wavelength of 1.854 microns (Group 1, n = 4) or 1.870 microns (Group 2, n = 4) and 100 to 150 mW power for 10 seconds. A focusing handpiece was coupled with an application mask and fixed by partial vacuum to the conjunctiva or cornea. The radiation was focused into the corneal stroma between 400 and 600 microns in Group 1 and set to 1000 microns in Group 2. Eight (Group 1, single ring) or 16 (Group 2, double ring) coagulations were applied. RESULTS: The refractive change increased with higher laser power and smaller ring diameters. Two rings of coagulations provided higher and more stable refractive changes of up to 5.66 diopters (D) than a single ring. The refractive effect stabilized between 3 and 6 months postoperatively. At 1 year, mean refractive change was +0.99 D +/- 0.39 (SD) in Group 1 and +2.32 +/- 2.24 D in Group 2. Extensive endothelial damage occurred in Group 1 but was minimal in Group 2. CONCLUSIONS: Diode LTK was used to treat hyperopia safely and effectively. Regression occurred mainly in the first 3 postoperative months. With a wavelength of 1.870 microns, corneal endothelial damage was limited.}, keywords = {Adult Aged Aged, 80 and over Blindness/*complications Corneal Stroma/pathology/physiopathology/*surgery Corneal Topography Female Humans Hyperopia/pathology/physiopathology/*surgery Laser Coagulation/adverse effects/*methods Male Middle Aged Postoperative Complications Safety}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9888074}, year = {1999}, type = {Journal Article} } |
Reginald
Birngruber,
J.
Noack, and
U.
Schmidt-Erfurth,
Confocal laserscanning fluorescence topography of chorioretinal vascular structures, Investigative Ophthalmology & Visual Science , vol. 40, no. 4, pp. S571-S571, 1999.
Confocal laserscanning fluorescence topography of chorioretinal vascular structures, Investigative Ophthalmology & Visual Science , vol. 40, no. 4, pp. S571-S571, 1999.
U.
Schmidt-Erfurth,
J.
Noack, and
S.
Teschner,
Confocal indocyanine green angiography with 3-dimensional topography. Results in choroid neovascularization (CNV), Ophthalmologe , vol. 96, no. 12, pp. 797-804, 1999.
Confocal indocyanine green angiography with 3-dimensional topography. Results in choroid neovascularization (CNV), Ophthalmologe , vol. 96, no. 12, pp. 797-804, 1999.
T.
Brendel,
D.
Theisen, and
Reginald
Birngruber,
Ablation Dynamics of High Energy IR Laser Pulses in Myocardial Revascularization, Biomedical Optics, OSA Technical Digest , pp. 152-154, 1999.
Ablation Dynamics of High Energy IR Laser Pulses in Myocardial Revascularization, Biomedical Optics, OSA Technical Digest , pp. 152-154, 1999.
N.
Koop,
C.
Wirbelauer,
A.
Tungler,
G.
Geerling, and
G. O.
Bastian,
Thermische Schädigung des Hornhautendothels bei der Dioden-Laserthermokeratoplastik., Ophthalmologe , vol. 96, pp. 392-397, 1999.
Thermische Schädigung des Hornhautendothels bei der Dioden-Laserthermokeratoplastik., Ophthalmologe , vol. 96, pp. 392-397, 1999.
1998
Robert
Huber,
Martin
Koch, and
Jochen
Feldmann,
Laser-induced thermal expansion of a scanning tunneling microscope tip measured with an atomic force microscope cantilever, Appl. Phys. Lett. , vol. 73, no. 17, pp. 2521-2523, Oct. 1998.
Laser-induced thermal expansion of a scanning tunneling microscope tip measured with an atomic force microscope cantilever, Appl. Phys. Lett. , vol. 73, no. 17, pp. 2521-2523, Oct. 1998.
DOI: | 10.1063/1.122502 |
Bibtex: | @Article{HU_1998_Huber_b, Title = {{Laser-induced thermal expansion of a scanning tunneling microscope tip measured with an atomic force microscope cantilever}}, Author = {Huber, R and Koch, M and Feldmann, J}, Journal = {Applied Physics Letters}, Year = {1998}, Number = {17}, Pages = {2521}, Volume = {73}, keywords = {AG-Huber}, Doi = {10.1063/1.122502}, ISSN = {00036951}, Url = {http://scitation.aip.org/content/aip/journal/apl/73/17/10.1063/1.122502} } |
U.M.
Noske,
U.
Schmidt-Erfurth,
C.
Meyer, and
H.
Diddens,
Lipidmetabolismus im Retinalen Pigmentepithel (RPE): Mögliche Bedeutung der Lipoprotein-Rezeptoren bei der Altersbezogenen Makuladegeneration, Ophthalmologe , vol. 95, pp. 814-819, 1998.
Lipidmetabolismus im Retinalen Pigmentepithel (RPE): Mögliche Bedeutung der Lipoprotein-Rezeptoren bei der Altersbezogenen Makuladegeneration, Ophthalmologe , vol. 95, pp. 814-819, 1998.
J.
Roider, and
E. S.
El Hifnawi,
Bubble formation as primary interaction mechanism in retinal laser exposure with 200-ns laser pulses, Lasers in Surgery and Medicine , vol. 22, no. 4, pp. 240-248, 1998.
Bubble formation as primary interaction mechanism in retinal laser exposure with 200-ns laser pulses, Lasers in Surgery and Medicine , vol. 22, no. 4, pp. 240-248, 1998.
DOI: | Doi 10.1002/(Sici)1096-9101(1998)22:4<240::Aid-Lsm9>3.0.Co;2-P |
File: | WOS:000073431700009 |
Bibtex: | @article{Roider1998, author = {Roider, J. and El Hifnawi, E. S. and Birngruber, R.}, title = {Bubble formation as primary interaction mechanism in retinal laser exposure with 200-ns laser pulses}, journal = {Lasers in Surgery and Medicine}, volume = {22}, number = {4}, pages = {240-248}, note = {Zl426 Times Cited:15 Cited References Count:23}, abstract = {Background and Objective: Retinal laser photocoagulation is generally performed by laser pulses of a few hundred milliseconds. The tissue interaction mechanism is a pure thermal interaction mechanism. As pulse duration gets shorter, different, non-thermal interaction mechanisms start to appear. The time domain for a change of tissue interaction mechanism seems to be in the ns and mu s range. The goal of this study was to characterize the tissue interaction mechanism with 200-ns laser pulses, which approximate the thermal relaxation time of single melanin granules. Materials and Methods: The retinas of 19 eyes of 10 rabbits were irradiated by 10 and 500 repetitive laser pulses (wavelength, 532 nm; repetition rate, 500 Hz; pulse duration, 200 ns; per pulse energy, 0-120 mu J; retinal spot size, 100 mu m). The effects were evaluated by fluorescein angiography, ophthalmoscopy and by theoretical thermal calculations. Light microscopy and transmission electron microscopy were additionally performed on lesions irradiated by 500 pulses. Results: Single pulse threshold energies for angiographic visibility were 3.5 mu J (10 pulses) and 2.1 mu J (500 pulses), for ophthalmoscopic visibility 9.0 mu J (10 pulses) vs. 8.6 mu J (500 pulses). At energy levels above ophthalmoscopic visibility macroscopically visible bubble formation inside the retina could be observed. This occurred at energy levels of 35 mu J (10 pulses) vs. 17 mu J (500 pulses). Microscopic evaluation of lesions irradiated with 500 pulses and energies at the angiographic threshold showed a damage primarily to the RPE. Additional outer segment damage of the photoreceptors could be found. A gap between damaged RPE cells and the outer segments could be repeatedly found as well as damaged RPE cells, which were detached from intact Bruch's membrane. Temperature calculation shows that temperatures above 100 degrees C may exist around single melanin granules. Conclusion: The studies suggest that RPE damage may occur by bubble formation around single melanin granules. (C) 1998 Wiley-Liss, Inc.}, keywords = {bubble laser melanin retina retinal pigment epithelium injury stress radiation}, ISSN = {0196-8092}, DOI = {Doi 10.1002/(Sici)1096-9101(1998)22:4<240::Aid-Lsm9>3.0.Co;2-P}, url = {<Go to ISI>://WOS:000073431700009}, year = {1998}, type = {Journal Article} } |
Dynamics of Thermal Microeffects: Rate Constants of Thermal Denaturation Measured by a Temperature-Jump Experiment, OSA TOPS , vol. 22, pp. 300-305, 1998.
J.
Noack,
D.X.
Hammer,
B.A.
Rockwell,
Alfred
Vogel, and
G. D.
Noojin,
Influence of pulse duration on mechanical effects after laser-induced breakdown in water, J Appl Phys , vol. 83, no. 12, pp. 7488-7495, 1998.
Influence of pulse duration on mechanical effects after laser-induced breakdown in water, J Appl Phys , vol. 83, no. 12, pp. 7488-7495, 1998.
G.
Geerling,
J.
Roider,
U.
Schmidt-Erfurth,
K.
Nahen,
E. S.
El Hifnawi,
H.
Laqua, and
Alfred
Vogel,
Initial clinical experience with the picosecond Nd: YLF laser for intraocular therapeutic applications, Br J Ohthalmol , vol. 82, no. 5, pp. 504-509, 1998.
Initial clinical experience with the picosecond Nd: YLF laser for intraocular therapeutic applications, Br J Ohthalmol , vol. 82, no. 5, pp. 504-509, 1998.
N.
Koop,
G.
Geerling,
J.
Kampmeier,
S.
Borcherding, and
K.
Kamm,
Diode laser thermokeratoplasty: application strategy and dosimetry, J Cataract Refract Surg , vol. 24, no. 9, pp. 1195-207, 1998.
Diode laser thermokeratoplasty: application strategy and dosimetry, J Cataract Refract Surg , vol. 24, no. 9, pp. 1195-207, 1998.
D.
Theisen, and
H.M.
Stubbe,
Endocardial Laser Revascularization with Single High Energy Laser Pulses, OSA TOPS , vol. 22, pp. 272-276, 1998.
Endocardial Laser Revascularization with Single High Energy Laser Pulses, OSA TOPS , vol. 22, pp. 272-276, 1998.
A.
Knipper,
G.
Dröge,
F.
Schroer, and
B.
Gromoll,
Fundamental Studies of Fiber-Guided Soft Tissue Cutting by Means of Pulsed Midinfrared IR lasers and their Application in Ureterotomy, J Biomed Opt , vol. 3, no. 1, pp. 85-95, 1998.
Fundamental Studies of Fiber-Guided Soft Tissue Cutting by Means of Pulsed Midinfrared IR lasers and their Application in Ureterotomy, J Biomed Opt , vol. 3, no. 1, pp. 85-95, 1998.
N.
Koop,
K.
Kamm,
G.
Geerling, and
J.
Kampmeier,
Laser Thermokeratoplastik: eine in vitro- und in vivo-Studie mit kontinuierlich emittierender Laserdiode im mittleren IR-Spektralbereich., Laser in der Medizin, Proc. Laser 97 , pp. 412-416, 1998.
Laser Thermokeratoplastik: eine in vitro- und in vivo-Studie mit kontinuierlich emittierender Laserdiode im mittleren IR-Spektralbereich., Laser in der Medizin, Proc. Laser 97 , pp. 412-416, 1998.
D.
Spiegel, and
W.
Wetzel,
Comparison of the efficacy of ER-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of patients with primary open-angle glaucoma, Ophthalmologe , vol. 95, no. 8, pp. 537-541, 1998.
Comparison of the efficacy of ER-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of patients with primary open-angle glaucoma, Ophthalmologe , vol. 95, no. 8, pp. 537-541, 1998.
DOI: | DOI 10.1007/s003470050312 |
File: | WOS:000075913700003 |
Bibtex: | @article{Spiegel1998, author = {Spiegel, D. and Wetzel, W. and Birngruber, R.}, title = {Comparison of the efficacy of ER-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of patients with primary open-angle glaucoma}, journal = {Ophthalmologe}, volume = {95}, number = {8}, pages = {537-541}, note = {119TQ Times Cited:3 Cited References Count:16}, abstract = {Purpose: This study was conducted to compare the efficacy of the Er-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of primary open - angle glaucoma. Methods: Twelve patients with POAG underwent ab externo laser sclerostomy using an Er-YAG laser (Sklerostom 2.9(R); lambda = 2940 nm, t = 200 mu s, 2 Hz, 400 mu m, 15 mJ). Only local medication was used, and there were no risk factors for failure. As a control group 12 patients out of 248 standardized trabeculectomies were matched in terms of age, sex, diagnosis and local medications. No antimetabolites were used in either group. Results: After a follow-up of 9 months in the sclerostomy group 53%; (7/12; P = 0.03) showed a patent fistula in comparison of 100% in the trabeculectomy group. There was a significantly lower mean IOP during the first postsurgical week in the group of sclerostomies (3.6 +/- 1.5 mmHg versus 7.5 +/- 2.7 mmHg; P = 0.0001) with a higher incidence of choroidal detachments (9/12 versus 2/12; P = 0.004). The choroidal detachments lasted longer in the sclerostomy group (3.5 months versus 0.3 months; P = 0.014). Iris incarcerations were found only in sclerostomies (7/12; P = 0.05). Conclusions: Based on these findings, Er-YAG laser sclerostomy prooved to be less effective than trabeculectomy in the treatment of glaucoma patients. Er-YAG laser sclerostomies were associated with a higher incidence of postsurgical complications such as hypotony, choroidal detachments and iris incarcerations. At this point Er-YAG laser sclerostomy is not superior to conventional trabeculectomy.}, keywords = {glaucoma er-yag laser sclerostomy trabeculectomy filtration surgery mitomycin aphakia}, ISSN = {0941-293X}, DOI = {DOI 10.1007/s003470050312}, url = {<Go to ISI>://WOS:000075913700003}, year = {1998}, type = {Journal Article} } |
Rolf H.
Eichenauer,
Gereon
Huettmann,
Stephan
Woermer,
Norbert
Koop,
Wolfgang
Beyer, and
Dieter
Jocham,
New balloon catheter system used for PDT in the human urinary bladder: accuracy of light distribution, pp. 138-144, 1998.
New balloon catheter system used for PDT in the human urinary bladder: accuracy of light distribution, pp. 138-144, 1998.
J.
Welzel,
E.
Lankenau, and
R.
Engelhardt,
Optical coherence tomography of the skin, Curr Probl Dermatol , vol. 26, pp. 27-37, 1998.
Optical coherence tomography of the skin, Curr Probl Dermatol , vol. 26, pp. 27-37, 1998.
File: | query.fcgi |
Bibtex: | @article{Welzel1998, author = {Welzel, J. and Lankenau, E. and Birngruber, R. and Engelhardt, R.}, title = {Optical coherence tomography of the skin}, journal = {Curr Probl Dermatol}, volume = {26}, pages = {27-37}, note = {1421-5721 (Print) Journal Article Research Support, Non-U.S. Gov't}, keywords = {Biomedical Engineering Blister/pathology Eczema/pathology Epidermis/anatomy & histology/pathology Humans Melanoma/pathology Optics Pemphigus/pathology Scabies/parasitology/pathology Skin/*anatomy & histology/pathology Skin Neoplasms/pathology Tomography/*methods}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9597313}, year = {1998}, type = {Journal Article} } |
J.
Roider,
C.
Lindemann,
S.
el, and
H.
Laqua,
Therapeutic range of repetitive nanosecond laser exposures in selective RPE photocoagulation, Graefes Arch Clin Exp Ophthalmol , vol. 236, no. 3, pp. 213-9, 1998.
Therapeutic range of repetitive nanosecond laser exposures in selective RPE photocoagulation, Graefes Arch Clin Exp Ophthalmol , vol. 236, no. 3, pp. 213-9, 1998.
File: | query.fcgi |
Bibtex: | @article{Roider1998, author = {Roider, J. and Lindemann, C. and el-Hifnawi el, S. and Laqua, H. and Birngruber, R.}, title = {Therapeutic range of repetitive nanosecond laser exposures in selective RPE photocoagulation}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {236}, number = {3}, pages = {213-9}, note = {0721-832X (Print) Journal Article}, abstract = {BACKGROUND: The aim of this study was to investigate whether selective damage the RPE while sparing the adjacent photoreceptors is possible with repetitive 200-ns pulses of Nd:YAG laser (532 nm) and what potential side effects can be expected with higher pulse energies. METHODS: We irradiated the retinas of 19 eyes of 10 chinchilla rabbits with 500 pulses from a Nd:YAG laser, each 200 ns in duration, at a repetition rate of 500 Hz (158 microns, 0-120 microJ). Threshold curves for different effects were established. Representative lesions were investigated by light and transmission electron microscopy. RESULTS: It was possible to produce lesions, which were only visible by fluorescein angiography. The ED50 threshold energy per pulse for visibility by fluorescein angiography was 2.1 microJ per pulse, for visibility by ophthalmoscopy 8.6 microJ. Bubble formation, an uncommon phenomenon in retinal photocoagulation, occurred at energies of 15-25 microJ. Hemorrhage occurred at surprisingly high energy levels of more than 100 microJ. Histology performed on lesions visible only by angiography showed damage primarily to the RPE and outer segments, with very little damage to some inner segments dependent on the energy used. CONCLUSIONS: Selective RPE damage is possible with repetitive 200-ns laser pulses and appropriate energy; however, the collateral damage to the adjacent retina is more pronounced than with repetitive microsecond laser pulses. There is no risk of hemorrhage of retinal photocoagulation with the repetitive 200-ns laser pulses at low energy levels which would be used clinically.}, keywords = {Animals Eye Injuries/etiology/pathology Fundus Oculi Laser Coagulation/adverse effects/*methods Photoreceptors/injuries/ultrastructure Pigment Epithelium of Eye/*surgery/ultrastructure Rabbits Reoperation Retinal Hemorrhage/etiology Safety}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9541826}, year = {1998}, type = {Journal Article} } |
J.
Noack, and
Alfred
Vogel,
Single-shot spatially resolved characterization of laser-induced shock waves in water, Appl Optics , vol. 37, no. 19, pp. 4092-4099, 1998.
Single-shot spatially resolved characterization of laser-induced shock waves in water, Appl Optics , vol. 37, no. 19, pp. 4092-4099, 1998.
R.J.
Scammon,
E.J.
Chapyak,
R.P.
Godwin, and
Alfred
Vogel,
Simulations of shock waces and cavitation bubbles produced in water by picosecond and nanosecond laser pulses, SPIE Proc. , vol. 3254, pp. 264-275, 1998.
Simulations of shock waces and cavitation bubbles produced in water by picosecond and nanosecond laser pulses, SPIE Proc. , vol. 3254, pp. 264-275, 1998.
U.
Schmidt-Erfurth, and
T.
Hasan,
Photodynamic therapy in ocular vascular disease (Reprinted from IEEE Journal of Selected Topics in Quantum Electronics, vol 2, 1996), Laser Physics , vol. 8, no. 1, pp. 191-198, 1998.
Photodynamic therapy in ocular vascular disease (Reprinted from IEEE Journal of Selected Topics in Quantum Electronics, vol 2, 1996), Laser Physics , vol. 8, no. 1, pp. 191-198, 1998.
1997
Y. T.
Pan, and
R.
Engelhardt,
Contrast limits of coherence-gated imaging in scattering media, Applied Optics , vol. 36, no. 13, pp. 2979-2983, 1997.
Contrast limits of coherence-gated imaging in scattering media, Applied Optics , vol. 36, no. 13, pp. 2979-2983, 1997.
DOI: | Doi 10.1364/Ao.36.002979 |
File: | WOS:A1997WX24200038 |
Bibtex: | @article{Pan1997, author = {Pan, Y. T. and Birngruber, R. and Engelhardt, R.}, title = {Contrast limits of coherence-gated imaging in scattering media}, journal = {Applied Optics}, volume = {36}, number = {13}, pages = {2979-2983}, note = {Wx242 Times Cited:50 Cited References Count:8}, abstract = {The fundamental difference between time-resolved and coherence-gated imaging modalities in scattering media is analyzed in terms of their optical transfer functions. The effectiveness of coherence gating for multiple-scattering rejection is shown by imaging a 100-mu m-thick razor blade hidden in the scattering phantoms (i.e., Intralipid suspensions) with different scattering coefficients. We found that the imaging contrast is limited by multiple scattering and speckle effects in high-scattering media, and the measured effective penetration depth of optical coherence tomography is approximately equal to six mean free paths under the experimental conditions of a numerical aperture of less than 0.1 and a scattering anisotropy of approximately 0.8. (C) 1997 Optical Society of America.}, keywords = {coherence-gated imaging time-resolved imaging low-coherence interference imaging contrast limits multiple scattering effects tissue optics tomography}, ISSN = {0003-6935}, DOI = {Doi 10.1364/Ao.36.002979}, url = {<Go to ISI>://WOS:A1997WX24200038}, year = {1997}, type = {Journal Article} } |
N.
Koop,
J.
Kampmeier,
A.
Bruhns,
M.
AsiyoVogel, and
R.
Engelhardt,
Corneal collagen denaturation in laser thermokeratoplasty (LTK), Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2514-2514, 1997.
Corneal collagen denaturation in laser thermokeratoplasty (LTK), Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2514-2514, 1997.
M
Asiyo-Vogel,
N
Koop,
R
Engelhardt,
R
Eggers, and
A
Vogel,
Darstellung von LTK-Läsionen durch optische Kurzkohärenztomographie (OCT) und Polarisationsmikroskopie nach Sirius-Rot-Färbung, Ophthalmologe , vol. 94, pp. 487-491, 1997.
Darstellung von LTK-Läsionen durch optische Kurzkohärenztomographie (OCT) und Polarisationsmikroskopie nach Sirius-Rot-Färbung, Ophthalmologe , vol. 94, pp. 487-491, 1997.
G.
Geerling,
N.
Koop,
C.
Wirbelauer, and
H.
Laqua,
Diode-laser thermokeratoplasty - First clinical experiences in human blind eyes, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2292-2292, 1997.
Diode-laser thermokeratoplasty - First clinical experiences in human blind eyes, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2292-2292, 1997.
Norbert
Koop,
Ralf
Brinkmann,
Eva
Lankenau,
Stefan
Flache, and
Ralf
Engelhardt,
Optische Kohärenztomographie der Kornea und des vorderen Augenabschnitts, Der Ophthalmologe , vol. 94, no. 7, pp. 481-486, 1997.
Optische Kohärenztomographie der Kornea und des vorderen Augenabschnitts, Der Ophthalmologe , vol. 94, no. 7, pp. 481-486, 1997.
File: | s003470050143 |
Bibtex: | @article{Koop1997, author = {Koop, Norbert and Brinkmann, Ralf and Lankenau, Eva and Flache, Stefan and Engelhardt, Ralf and Birngruber, Reginald}, title = {Optische Kohärenztomographie der Kornea und des vorderen Augenabschnitts}, journal = {Der Ophthalmologe}, volume = {94}, number = {7}, pages = {481-486}, ISSN = {1433-0423}, url = {http://dx.doi.org/10.1007/s003470050143}, year = {1997}, type = {Journal Article} } |
D.
Spiegel, and
W.
Wetzel,
Comparison of the efficacy of Er-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of ''low risk'' glaucoma patients., Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 829-829, 1997.
Comparison of the efficacy of Er-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of ''low risk'' glaucoma patients., Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 829-829, 1997.
M. N.
Asiyo-Vogel,
N.
Koop,
R.
Engelhardt,
R.
Eggers, and
Alfred
Vogel,
Evaluation of LTK lesions by optical low coherence tomography (OCT) and polarization microscopy after Sirius-Red staining, Ophthalmologe , vol. 94, no. 7, pp. 487-491, 1997.
Evaluation of LTK lesions by optical low coherence tomography (OCT) and polarization microscopy after Sirius-Red staining, Ophthalmologe , vol. 94, no. 7, pp. 487-491, 1997.
DOI: | DOI 10.1007/s003470050144 |
File: | WOS:000071246700004 |
Bibtex: | @article{Asiyo-Vogel1997, author = {Asiyo-Vogel, M. N. and Koop, N. and Brinkmann, R. and Engelhardt, R. and Eggers, R. and Birngruber, R. and Vogel, A.}, title = {Evaluation of LTK lesions by optical low coherence tomography (OCT) and polarization microscopy after Sirius-Red staining}, journal = {Ophthalmologe}, volume = {94}, number = {7}, pages = {487-491}, note = {Yp140 Times Cited:5 Cited References Count:21}, abstract = {Background: Information on the extent and degree of the thermal effect produced is of great importance for control of the laser dosage in laser thermokeratoplasty (LTK) and for postoperative follow-up. We investigated on acute LTK effects which information images obtained by optical low coherence tomography (OCT) offer compared to those obtained by polarization microscopy. Methods: Porcine eyes were irradiated through a 400 mu m quartz fiber using light from a laser diode emitting up to 300 mW at a wavelength of 1.86 mu m. Thermal lesions of varying strength were scanned using an experimental OCT device with about 25 mu m lateral and 20 mu m axial resolution. Histologic evaluation of the scanned areas was done by polarization microscopy after Sirius-Red staining, and similar lesions were also analyzed by TEM. Results: Both methods differentiated three damage zones: a transition zone, a zone of moderate coagulation, and a central zone of strong coagulation. In the transition zone,increased birefringence was seen in polarization microscopy, which correlated with increased light scattering seen in the DCT images,ln the moderately coagulated zone, a decrease in birefringence was associated with an even stronger increase of the OCT signal, In the central zone,a loss of the fibrillar tissue structure was observed, which led to a complete loss of birefringence and a strong reduction of the OCT signal. Conclusions: Although OCT does not provide the detailed information on thermal changes of tissue seen by the histologic method, it offers information on the extent and degree of tissue changes without preparation artifacts and provides a non-invasive method of immediate and follow-up control of LTK lesions, A quantitative analysis of changes in corneal thickness and curvature is much simpler than by a slit lamp. Time-resolved measurements of corneal light scattering may be used for on-line control of the laser-light dosage during LTK.}, keywords = {refractive surgery laser thermokeratoplasty collagen denaturation collagen shrinkage optical low coherence tomography polarization microscopy sirius-red staining tissue collagen eye}, ISSN = {0941-293X}, DOI = {DOI 10.1007/s003470050144}, url = {<Go to ISI>://WOS:000071246700004}, year = {1997}, type = {Journal Article} } |
Alfred
Vogel,
T.
Günther, and
M.
Asiyo-Vogel,
Factors determining the refractive effects of intrastromal photorefractive keratectomy with the picosecond laser, J Cataract Refract Surg , vol. 23, no. 9, pp. 1301-1310, 1997.
Factors determining the refractive effects of intrastromal photorefractive keratectomy with the picosecond laser, J Cataract Refract Surg , vol. 23, no. 9, pp. 1301-1310, 1997.
M.
Asiyo-Vogel,
H.
Notbohm,
R.
Eggers,
H.
Lubatschowski,
H.
Laqua, and
Alfred
Vogel,
Histologic analysis of thermal effects of laserthermokeratoplasty and corneal ablation using Sirius-Red polarization microscopy, J Cataract Refr Surg , vol. 23, pp. 515-526, 1997.
Histologic analysis of thermal effects of laserthermokeratoplasty and corneal ablation using Sirius-Red polarization microscopy, J Cataract Refr Surg , vol. 23, pp. 515-526, 1997.
C.
Hendrich,
C.
Lehnert,
H.
Diddens, and
W.E.
Siebert,
Photodynamic laser therapy for rheumatoid arthritis: Cell culture studies and animal experiments., Knee Surg Sports Traumatol Arthroscopy , vol. 5, pp. 58-63, 1997.
Photodynamic laser therapy for rheumatoid arthritis: Cell culture studies and animal experiments., Knee Surg Sports Traumatol Arthroscopy , vol. 5, pp. 58-63, 1997.
J.
Noack,
R.
Tonnies,
K.
Hohla, and
Alfred
Vogel,
Influence of ablation plume dynamics on the formation of central islands in excimer laser photorefractive keratectomy, Ophthalmology , vol. 104, no. 5, pp. 823-30, 1997.
Influence of ablation plume dynamics on the formation of central islands in excimer laser photorefractive keratectomy, Ophthalmology , vol. 104, no. 5, pp. 823-30, 1997.
Alfred
Vogel,
T.
Günther, and
M.
Asiyo-Vogel,
Investigations on the origin of refractive effects in intrastromal refractive surgery with the picosecond laser, Ophthalmologe , vol. 94, no. 7, pp. 467-474, 1997.
Investigations on the origin of refractive effects in intrastromal refractive surgery with the picosecond laser, Ophthalmologe , vol. 94, no. 7, pp. 467-474, 1997.
DOI: | DOI 10.1007/s003470050141 |
File: | WOS:000071246700001 |
Bibtex: | @article{Vogel1997, author = {Vogel, A. and Gunther, T. and Asiyo-Vogel, M. and Birngruber, R.}, title = {Investigations on the origin of refractive effects in intrastromal refractive surgery with the picosecond laser}, journal = {Ophthalmologe}, volume = {94}, number = {7}, pages = {467-474}, note = {Yp140 Times Cited:2 Cited References Count:21}, abstract = {Background: Picosecond laser intrastromal photorefractive keratectomy (ISPRK) aims at achieving a flattening of the central cornea by plasma-mediated tissue evaporation without affecting the anterior or posterior corneal layers. We investigated the laser-induced tissue effects to establish a functional relationship between laser parameters and tissue removal and to assess their influence on the healing process and long-term refractive changes. Materials and methods: A modified ISL 2001 System with a cone angle of 30 degrees was used for in vitro investigations of the laser effects in water and porcine cornea. Photographic methods were used to determine the plasma volume and the thickness of the laser-generated intrastromal bubble layer as a function of the pulse energy and the number and separation in which the pulses were applied (216 eyes). Histological evaluation was done by polarization microscopy (9 eyes). Results: Polarization microscopy revealed only minor signs of thermal tissue damage. The maximum amount of tissue that can be evaporated without damaging the outer corneal layers corresponds to a layer about 10 mu m thick. With a 6-mm optical zone, this tissue removal yields an immediate refractive effect of only 0.85 dpt. Stronger long-term refractive changes observed in animal experiments and clinical studies must thus be due to the healing response of the cornea. The healing response may be induced by mechanical distortion due to intrastromal bubble formation affecting about one third of the corneal thickness. Conclusion: Since the refractive effects are apparently strongly influenced by corneal healing, they are poorly predictable and can probably not be used for clinical purposes.}, keywords = {refractive surgery intrastromal photorefractive keratectomy picosecond laser photodisruption cavitation photorefractive keratectomy intraocular photodisruption corneal tissue pulses}, ISSN = {0941-293X}, DOI = {DOI 10.1007/s003470050141}, url = {<Go to ISI>://WOS:000071246700001}, year = {1997}, type = {Journal Article} } |
J.
Kampmeier,
M.
Pfleiderer, and
E.
Schneider,
Laser thermokeratoplasty (LTK): A finite element model of the cornea, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2515-2515, 1997.
Laser thermokeratoplasty (LTK): A finite element model of the cornea, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2515-2515, 1997.
U.
SchmidtErfurth,
W.
Wetzel, and
G.
Dröge,
Mitomycin-C in laser sclerostomy: Benefit and complications, Ophthalmic Surgery and Lasers , vol. 28, no. 1, pp. 14-20, 1997.
Mitomycin-C in laser sclerostomy: Benefit and complications, Ophthalmic Surgery and Lasers , vol. 28, no. 1, pp. 14-20, 1997.
J.
Welzel,
E.
Lankenau, and
R.
Engelhardt,
Optical coherence tomography of the human skin, J Am Acad Dermatol , vol. 37, no. 6, pp. 958-63, 1997.
Optical coherence tomography of the human skin, J Am Acad Dermatol , vol. 37, no. 6, pp. 958-63, 1997.
File: | query.fcgi |
Bibtex: | @article{Welzel1997, author = {Welzel, J. and Lankenau, E. and Birngruber, R. and Engelhardt, R.}, title = {Optical coherence tomography of the human skin}, journal = {J Am Acad Dermatol}, volume = {37}, number = {6}, pages = {958-63}, note = {0190-9622 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't}, abstract = {BACKGROUND: Optical coherence tomography (OCT) is a new diagnostic method for tissue characterization. OBJECTIVE: We investigated normal and pathologic structures in human skin in several locations to evaluate the potential application of this technique to dermatology. METHODS: Based on the principle of low-coherence interferometry, cross-sectional images of the human skin can be obtained in vivo with a high spatial resolution of about 15 microns. Within a penetration depth of 0.5 to 1.5 mm, structures of the stratum corneum, the living epidermis, and the papillary dermis can be distinguished. RESULTS: Different layers could be detected that were differentiated by induction of experimental blisters and by comparison with corresponding histologic sections. Furthermore, OCT images of several skin diseases and tumors were obtained. CONCLUSION: OCT is a promising new imaging method for visualization of morphologic changes of superficial layers of the human skin. It may be useful for noninvasive diagnosis of bullous skin diseases, skin tumors, and in vivo investigation of pharmacologic effects.}, keywords = {Adult Anatomy, Cross-Sectional Basement Membrane/pathology Blister/diagnosis/pathology Epidermis/anatomy & histology Evaluation Studies Female Forearm/anatomy & histology Hand/anatomy & histology Humans Hutchinson's Melanotic Freckle/diagnosis/pathology Image Enhancement Interferometry Male Melanoma/diagnosis/pathology Nails/anatomy & histology Optics Skin/*anatomy & histology Skin Diseases/*diagnosis/pathology Skin Diseases, Vesiculobullous/diagnosis/pathology Skin Neoplasms/diagnosis/pathology Tomography/*methods}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9418764}, year = {1997}, type = {Journal Article} } |
D.
Spiegel, and
W.
Wetzel,
Comparison of the efficacy of Er-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of "low risk" glaucoma patients., Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 829-829, 1997.
Comparison of the efficacy of Er-YAG laser sclerostomy ab externo versus trabeculectomy in the treatment of "low risk" glaucoma patients., Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 829-829, 1997.
G
Dröge,
F
Schroer,
M
Scheu, and
Reginald
Birngruber,
Ablation Dynamics in Laser Sclerostomy Ab Externo by means of Pulsed Lasers in the Mid-Infrared Spectral Range, Ophth Surg Las , vol. 28, no. 10, pp. 853-865, 1997.
Ablation Dynamics in Laser Sclerostomy Ab Externo by means of Pulsed Lasers in the Mid-Infrared Spectral Range, Ophth Surg Las , vol. 28, no. 10, pp. 853-865, 1997.
N.
Koop,
M.
Langholz,
G.
Geerling, and
G. O.
Bastian,
Comparative evaluation of different corneal topographical devices, Ophthalmologe , vol. 94, no. 2, pp. 120-126, 1997.
Comparative evaluation of different corneal topographical devices, Ophthalmologe , vol. 94, no. 2, pp. 120-126, 1997.
DOI: | DOI 10.1007/s003470050092 |
File: | WOS:000071245600008 |
Bibtex: | @article{Koop1997, author = {Koop, N. and Langholz, M. and Birngruber, R. and Geerling, G. and Bastian, G. O.}, title = {Comparative evaluation of different corneal topographical devices}, journal = {Ophthalmologe}, volume = {94}, number = {2}, pages = {120-126}, note = {Yp129 Times Cited:0 Cited References Count:25}, abstract = {Purpose: It is difficult to measure the topography of the cornea with high resolution and visualize it on a map displaying refraction. This is demonstrated by the ongoing improvement and further development of different methods and by the fact that users of these techniques are not always satisfied. Materials and methods: Five different ring projectors were compared. Spherical and aspherical ball standards were used to measure the standard deviation of the refraction of the system. A patient group of eight people with healthy eyes was used to compare the measurement accuracy and operational errors. Some patients were also measured after cataract surgery. The lateral and axial range of the devices was determined. Results: The measurement accuracy for bail stand ards for the five devices was below 1/8 D. For the in vivo case in the control group it was below 1/4 D for four devices. Furthermore, the reproducibility of the results, the accuracy of angle determination and the influence of mechanical and optical design will be discussed. The study demonstrates applications and limits of this measurement method.}, keywords = {placido-disk corneal topography refractive power videokeratoscope accuracy system reproducibility}, ISSN = {0941-293X}, DOI = {DOI 10.1007/s003470050092}, url = {<Go to ISI>://WOS:000071245600008}, year = {1997}, type = {Journal Article} } |
Alfred
Vogel,
Thomas
Günther, and
M
Asyo-Vogel,
Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser, Der Ophthalmologe , vol. 94, no. 7, pp. 467-474, 1997.
Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser, Der Ophthalmologe , vol. 94, no. 7, pp. 467-474, 1997.
DOI: | 10.1007/s003470050141 |
File: | s003470050141 |
Bibtex: | @article{Vogel1997, author = {Vogel, Alfred and Günther, Thomas and Birngruber, Reginald and Asyo-Vogel, M}, title = {Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser}, journal = {Der Ophthalmologe}, volume = {94}, number = {7}, pages = {467-474}, keywords = {Schlüsselwörter Refraktive Hornhautchirurgie Intrastromale photorefraktive Keratektomie Pikosekundenlaser Photodisruption Kavitation Key words Refractive surgery Intrastromal photorefractive keratectomy Picosecond laser Cavitation}, ISSN = {0941-293X}, DOI = {10.1007/s003470050141}, url = {http://dx.doi.org/10.1007/s003470050141}, year = {1997}, type = {Journal Article} } |
U.
SchmidtErfurth,
H.
Diddens, and
T.
Hasan,
Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates, British Journal of Cancer , vol. 75, no. 1, pp. 54-61, 1997.
Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates, British Journal of Cancer , vol. 75, no. 1, pp. 54-61, 1997.
DOI: | Doi 10.1038/Bjc.1997.9 |
File: | WOS:A1997WA34400009 |
Bibtex: | @article{Schmidt-Erfurth1997, author = {SchmidtErfurth, U. and Diddens, H. and Birngruber, R. and Hasan, T.}, title = {Photodynamic targeting of human retinoblastoma cells using covalent low-density lipoprotein conjugates}, journal = {British Journal of Cancer}, volume = {75}, number = {1}, pages = {54-61}, note = {Wa344 Times Cited:69 Cited References Count:64}, abstract = {Combination of photosensitizers with carrier molecules has been shown to enhance the efficiency of photodynamic therapy (PDT). Owing to an increased expression of their receptors on some malignant and proliferating cells, low-density lipoproteins (LDLs) are potential endogenous carriers. A photosensitizer, chlorin e(6) (Ce-6), was covalently bound to LDL via carbodiimide activation. The Ce-6-LDL conjugate was evaluated on a fibroblast cell line with defined LDL receptor expression and a retinoblastoma cell line (Y79). Uptake of free Ce-6 and Ce-6 either covalently bound to or complexed with LDL was measured by spectrofluorimetry. Phototoxicity after irradiation at 660 nm was determined by a mitochondrial activity assay (MTT). Covalent binding to LDL significantly increased the uptake of Ce, for both cell lines by a factor of 4-5. A Ce-6:LDL binding ratio of 50:1 was optimal. A receptor-mediated uptake was demonstrated by saturability and competitive inhibition by free LDL. Binding also occurred at 2 degrees C and was attributed to non-specific associations. Irradiation with 10 J cm(-2) of 660 nm light after treatment of cells with Ce-6-LDL conjugate reduced the MTT activity by 80%, while free or mixed Ce-6 induced a maximum of 10% reduction in the MTT activity following identical treatment conditions. These data suggest that targeting of LDL receptor-bearing cells using covalently bound carriers, such as LDL, might increase the efficiency and selectivity of PDT. Intraocular tumours such as retinoblastomas could be appropriate targets for such an approach owing to the ease of access of light sources and the need for non-invasive approaches in sensitive ocular sites.}, keywords = {photochemistry ocular neovascularization chlorin bladder-carcinoma cells receptor-mediated uptake plasma-lipoproteins endothelial-cells human fibroblasts cellular-uptake therapy tumor benzoporphyrin cancer}, ISSN = {0007-0920}, DOI = {Doi 10.1038/Bjc.1997.9}, url = {<Go to ISI>://WOS:A1997WA34400009}, year = {1997}, type = {Journal Article} } |
U.
SchmidtErfurth,
J. W.
Miller,
M.
Sickenberg,
N. M.
Bressler,
H.
Laqua,
E. S.
Gragoudas,
L.
Zografos,
A.
Hager,
B.
Piguet,
H.
vandenBergh,
H. A.
Strong, and
M.
Fsadni,
Photodynamic therapy for choroidal neovascularisation in a phase I/II study: Preliminary results of multiple treatments, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 74-74, 1997.
Photodynamic therapy for choroidal neovascularisation in a phase I/II study: Preliminary results of multiple treatments, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 74-74, 1997.
M.
Sickenberg,
U.
SchimdtErfurth,
J. W.
Miller,
G.
Donati,
N. M.
Bressler,
L.
Zografos,
B.
Piguet,
H.
Laqua,
E. S.
Gragoudas,
A. M.
Lane,
C.
Pournaras,
H.
vandenBergh,
H. A.
Strong,
U.
Manjuris, and
M.
Fsadni,
Preliminary results of photodynamic therapy for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome and idiopathic causes within a phase I/II study, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 450-450, 1997.
Preliminary results of photodynamic therapy for choroidal neovascularization in pathologic myopia, ocular histoplasmosis syndrome and idiopathic causes within a phase I/II study, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 450-450, 1997.
E. S.
Gragoudas,
U.
SchmidtErfurth,
M.
Sickenberg,
C. J.
Pournaras,
N. M.
Bressler,
A.
Strong,
U.
Hoehne,
M.
Fsadni,
A. M.
Lane,
H.
Laqua,
G.
Donati,
L.
Zografos,
H.
vandenBergh,
B.
Piguet, and
J. W.
Miller,
Results and preliminary dosimetry of photodynamic therapy for choroidal neovascularization in age-related macular degeneration in a phase I/II study., Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 73-73, 1997.
Results and preliminary dosimetry of photodynamic therapy for choroidal neovascularization in age-related macular degeneration in a phase I/II study., Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 73-73, 1997.
D.X.
Hammer,
E.D.
Jansen,
M.
Frenz,
G.D.
Nojin,
R.J.
Thomas,
J.
Noack,
Alfred
Vogel,
B.A.
Rockwell, and
A.J.
Welch,
Shielding properties of laser-induced breakdown in water from pulse durations from 5 ns to 125 fs., Appl Optics , vol. 36, pp. 5630-5640, 1997.
Shielding properties of laser-induced breakdown in water from pulse durations from 5 ns to 125 fs., Appl Optics , vol. 36, pp. 5630-5640, 1997.
J.
Roider, and
H.
Laqua,
Therapeutical bandwidth or selective RPE-photocoagulation treatment by repetitive mu s-laser pulses (527 nm) - First clinical results, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 404-404, 1997.
Therapeutical bandwidth or selective RPE-photocoagulation treatment by repetitive mu s-laser pulses (527 nm) - First clinical results, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 404-404, 1997.
Alfred
Vogel,
Thomas
Günther, and
M
Asyo-Vogel,
Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser, Der Ophthalmologe , vol. 94, no. 7, pp. 467-474, 1997.
Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser, Der Ophthalmologe , vol. 94, no. 7, pp. 467-474, 1997.
DOI: | 10.1007/s003470050141 |
File: | s003470050141 |
Bibtex: | @article{Vogel1997, author = {Vogel, Alfred and Günther, Thomas and Birngruber, Reginald and Asyo-Vogel, M}, title = {Untersuchungen zur Entstehung von Refraktionseffekten bei der intrastromalen refraktiven Hornhautchirurgie mit dem Pikosekundenlaser}, journal = {Der Ophthalmologe}, volume = {94}, number = {7}, pages = {467-474}, keywords = {Schlüsselwörter Refraktive Hornhautchirurgie Intrastromale photorefraktive Keratektomie Pikosekundenlaser Photodisruption Kavitation Key words Refractive surgery Intrastromal photorefractive keratectomy Picosecond laser Cavitation}, ISSN = {0941-293X}, DOI = {10.1007/s003470050141}, url = {http://dx.doi.org/10.1007/s003470050141}, year = {1997}, type = {Journal Article} } |
C. A.
Toth,
S. A.
Boppart,
M. R.
Hee,
C. D.
DiCarlo,
E. A.
Swanson,
C. P.
Cain,
D. G.
Narayan,
G. D.
Noojin, and
W. P.
Roach,
Argon laser retinal lesions evaluated in vivo by optical coherence tomography, Am J Ophthalmol , vol. 123, no. 2, pp. 188-98, 1997.
Argon laser retinal lesions evaluated in vivo by optical coherence tomography, Am J Ophthalmol , vol. 123, no. 2, pp. 188-98, 1997.
File: | query.fcgi |
Bibtex: | @article{Toth1997, author = {Toth, C. A. and Birngruber, R. and Boppart, S. A. and Hee, M. R. and Fujimoto, J. G. and DiCarlo, C. D. and Swanson, E. A. and Cain, C. P. and Narayan, D. G. and Noojin, G. D. and Roach, W. P.}, title = {Argon laser retinal lesions evaluated in vivo by optical coherence tomography}, journal = {Am J Ophthalmol}, volume = {123}, number = {2}, pages = {188-98}, note = {0002-9394 (Print) Journal Article Research Support, U.S. Gov't, Non-P.H.S.}, abstract = {PURPOSE: To assess the in vivo evolution of argon laser retinal lesions by correlating the cross-sectional structure from sequential optical coherence tomography with histopathologic sectioning. METHODS: Argon laser lesions were created in the retinas of Macaca mulatta and evaluated by cross-section optical coherence tomography, which was compared at selected time points with corresponding histopathology. RESULTS: Argon laser lesions induced an optical coherence tomography pattern of early outer retinal relative high reflectivity with subsequent surrounding relative low reflectivity that correlated well with histopathologic findings. The in vivo optical coherence tomography images of macular laser lesions clearly demonstrated differences in pathologic response by retinal layer over time. CONCLUSION: The novel sequential imaging of rapidly evolving macular lesions with optical coherence tomography provides new insight into the patterns of acute tissue response by cross-sectional layer. This sequential imaging technique will aid in our understanding of the rapid evolution of retinal pathology and response to treatment in the research and clinical setting.}, keywords = {Animals Argon *Lasers Macaca mulatta *Optics Retina/*pathology/*radiation effects Time Factors Tomography/*methods}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9186124}, year = {1997}, type = {Journal Article} } |
Norbert
Koop,
Michael
Langholz,
Gerd
Geerling, and
Gerd-Otto
Bastian,
Vergleichende Untersuchungen verschiedener kornealer Topographiemeßgeräte, Der Ophthalmologe , vol. 94, no. 2, pp. 120-126, 1997.
Vergleichende Untersuchungen verschiedener kornealer Topographiemeßgeräte, Der Ophthalmologe , vol. 94, no. 2, pp. 120-126, 1997.
File: | s003470050092 |
Bibtex: | @article{Koop1997, author = {Koop, Norbert and Langholz, Michael and Birngruber, Reginald and Geerling, Gerd and Bastian, Gerd-Otto}, title = {Vergleichende Untersuchungen verschiedener kornealer Topographiemeßgeräte}, journal = {Der Ophthalmologe}, volume = {94}, number = {2}, pages = {120-126}, ISSN = {1433-0423}, url = {http://dx.doi.org/10.1007/s003470050092}, year = {1997}, type = {Journal Article} } |
J.
Chapyak,
R.P.
Godwin, and
Alfred
Vogel,
A comparison of numerical simulations and laboratory studies on shock waves and cavitation bubble growth produced by optical breakdown in water, SPIE Proc. , vol. 2975, pp. 335-342, 1997.
A comparison of numerical simulations and laboratory studies on shock waves and cavitation bubble growth produced by optical breakdown in water, SPIE Proc. , vol. 2975, pp. 335-342, 1997.
J.
Welzel,
E.
Lankenau, and
R.
Engelhardt,
Optical coherence tomography of the human skin, J Am Acad Dermatol , vol. 37, no. 6, pp. 958-63, 1997.
Optical coherence tomography of the human skin, J Am Acad Dermatol , vol. 37, no. 6, pp. 958-63, 1997.
File: | query.fcgi |
Bibtex: | @article{Welzel1997, author = {Welzel, J. and Lankenau, E. and Birngruber, R. and Engelhardt, R.}, title = {Optical coherence tomography of the human skin}, journal = {J Am Acad Dermatol}, volume = {37}, number = {6}, pages = {958-63}, note = {0190-9622 (Print) Comparative Study Journal Article Research Support, Non-U.S. Gov't}, abstract = {BACKGROUND: Optical coherence tomography (OCT) is a new diagnostic method for tissue characterization. OBJECTIVE: We investigated normal and pathologic structures in human skin in several locations to evaluate the potential application of this technique to dermatology. METHODS: Based on the principle of low-coherence interferometry, cross-sectional images of the human skin can be obtained in vivo with a high spatial resolution of about 15 microns. Within a penetration depth of 0.5 to 1.5 mm, structures of the stratum corneum, the living epidermis, and the papillary dermis can be distinguished. RESULTS: Different layers could be detected that were differentiated by induction of experimental blisters and by comparison with corresponding histologic sections. Furthermore, OCT images of several skin diseases and tumors were obtained. CONCLUSION: OCT is a promising new imaging method for visualization of morphologic changes of superficial layers of the human skin. It may be useful for noninvasive diagnosis of bullous skin diseases, skin tumors, and in vivo investigation of pharmacologic effects.}, keywords = {Adult Anatomy, Cross-Sectional Basement Membrane/pathology Blister/diagnosis/pathology Epidermis/anatomy & histology Evaluation Studies Female Forearm/anatomy & histology Hand/anatomy & histology Humans Hutchinson's Melanotic Freckle/diagnosis/pathology Image Enhancement Interferometry Male Melanoma/diagnosis/pathology Nails/anatomy & histology Optics Skin/*anatomy & histology Skin Diseases/*diagnosis/pathology Skin Diseases, Vesiculobullous/diagnosis/pathology Skin Neoplasms/diagnosis/pathology Tomography/*methods}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9418764}, year = {1997}, type = {Journal Article} } |
C. A.
Toth,
D. G.
Narayan,
S. A.
Boppart,
M. R.
Hee,
C. P.
Cain,
C. D.
DiCarlo,
W. P.
Roach, and
Reginald
Birngruber,
A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy, Arch Ophthalmol , vol. 115, no. 11, pp. 1425-8, 1997.
A comparison of retinal morphology viewed by optical coherence tomography and by light microscopy, Arch Ophthalmol , vol. 115, no. 11, pp. 1425-8, 1997.
Alfred Vogel,
Nonlinear absorption: intraocular microsurgery and laser lithotripsy , Phys. Med. Biol. , vol. 42, no. 5, pp. 895, 1997.
Nonlinear absorption: intraocular microsurgery and laser lithotripsy , Phys. Med. Biol. , vol. 42, no. 5, pp. 895, 1997.
C.
Wirbelauer,
G.
Geerling,
N.
Koop,
A.
Tungler,
H.
Laqua, and
Reginald
Birngruber,
Acute endothelial cell changes after laser thermal keratoplasty with a CW-IR laser diode, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2516-2516, 1997.
Acute endothelial cell changes after laser thermal keratoplasty with a CW-IR laser diode, Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2516-2516, 1997.
N.
Koop,
E.
Lankenau,
S.
Flache, and
R.
Engelhardt,
Optical coherence tomography of cornea and anterior segment of the eye, Ophthalmologe , vol. 94, no. 7, pp. 481-486, 1997.
Optical coherence tomography of cornea and anterior segment of the eye, Ophthalmologe , vol. 94, no. 7, pp. 481-486, 1997.
DOI: | DOI 10.1007/s003470050143 |
File: | WOS:000071246700003 |
Bibtex: | @article{Koop1997, author = {Koop, N. and Brinkmann, R. and Lankenau, E. and Flache, S. and Engelhardt, R. and Birngruber, R.}, title = {Optical coherence tomography of cornea and anterior segment of the eye}, journal = {Ophthalmologe}, volume = {94}, number = {7}, pages = {481-486}, note = {Yp140 Times Cited:34 Cited References Count:19}, abstract = {Target: The method of optical coherence tomography (OCT) was investigated regarding its suitability and limits for measuring the cornea and the anterior segment of the eye. Furthermore, the stromal expansion of thermally induced lesions in the cornea directly after irradiation was determined within the scope of the laser thermokeratoplasty (LTK). Material and methods: With the experimental scanning OCT system, x-z sections of the anterior eye segment were made with an optical resolution of about 20 mu m axially and 25 mu m laterally. Freshly enucleated, tonicized porcine eyes were used as model eyes. Thermal lesions were applied with a continuously emitting laser diode (lambda=1.86 mu m) and various radiation parameters, Before and after coagulation, the cornea was viewed from limbus to limbus in a central OCT scan and the individual coagulation source was measured, Results: Global and local changes of the thickness of the cornea as well as the distance between cornea and lens were measured with high precision. Thermal lesions in their expansion can be clearly presented and matching well with the histologically stained sections, bur are not as exactly defined at the edges due to the limited optical resolution, as known from histological preparations. Conclusion: With the OCT method quantitative measuring of the anterior eye segment can be performed in vitro and with reduced resolutions also in vivo. Due to the qualitatively good correspondence regarding the dimensions of thermal damage of the cornea with histologically obtained morphometric results,this method can be used for supervision of coagulation directly after LTK as well as for examination of the individual healing process.}, keywords = {optical coherence tomography pachometry laser thermokeratoplasty thermal damage tissue}, ISSN = {0941-293X}, DOI = {DOI 10.1007/s003470050143}, url = {<Go to ISI>://WOS:000071246700003}, year = {1997}, type = {Journal Article} } |
1996
S
Verges, and
E F
Stange,
Über die Schnittwirkung des Holmium-Lasers in der Magen-und Darmschleimhaut des Schweines, Lasermedizin , vol. 12, pp. 9-16, 1996.
Über die Schnittwirkung des Holmium-Lasers in der Magen-und Darmschleimhaut des Schweines, Lasermedizin , vol. 12, pp. 9-16, 1996.
C.
Hansen,
D.
Mohrenstecher, and
M.
Scheu,
Analysis of cavitation dynamics during pulsed laser tissue ablation by optical on-line monitoring, Ieee Journal of Selected Topics in Quantum Electronics , vol. 2(4), pp. 826-835, 1996.
Analysis of cavitation dynamics during pulsed laser tissue ablation by optical on-line monitoring, Ieee Journal of Selected Topics in Quantum Electronics , vol. 2(4), pp. 826-835, 1996.
DOI: | Doi 10.1109/2944.577305 |
File: | WOS:A1996XD61600006 |
Bibtex: | @article{Brinkmann1996-1, author = {Brinkmann, R. and Hansen, C. and Mohrenstecher, D. and Scheu, M. and Birngruber, R.}, title = {Analysis of cavitation dynamics during pulsed laser tissue ablation by optical on-line monitoring}, journal = {Ieee Journal of Selected Topics in Quantum Electronics}, volume = {2(4)}, pages = {826-835}, note = {Xd616 Times Cited:20 Cited References Count:24}, abstract = {Flashlamp pumped mid-IR laser systems emitting in the 23-mu m wavelength range are widely used for various medical applications, especially for tissue ablation, Explosive evaporation is inevitably associated with this process due to the short pulse durations of these laser systems and the high absorption of tissue and water in this spectral regime, Tissue displacement and dissection occur in liquid environment as a consequence of the induced cavitation, Depending on the application these processes might enhance the tissue ablation but can also cause adverse tissue effects, The ablation dynamics were investigated by evaluating the change in rejected probe-light intensity reemitted from the application fiber tip. The ablated cavity and the signal was correlated to fast-flash photographs of the event. Based on this reflection signal a water/tissue discrimination system is introduced which can widely support medical laser applications. In laser sclerostomy ab externo, for example, this approach can be used as a feedback system to automatically control the ablation process. With such a system, adverse effects to adjacent tissue in the anterior chamber of the eye can be minimized.}, ISSN = {1077-260X}, DOI = {Doi 10.1109/2944.577305}, url = {<Go to ISI>://WOS:A1996XD61600006}, year = { 1996}, type = {Journal Article} } |
R
Schmidt Erfurth, and
T
Hasan,
Photodynamic therapy in ocular vascular disease, Ieee Journal of Selected Topics in Quantum Electronics , pp. 988-996, 1996.
Photodynamic therapy in ocular vascular disease, Ieee Journal of Selected Topics in Quantum Electronics , pp. 988-996, 1996.
DOI: | Doi 10.1109/2944.577328 |
File: | WOS:A1996XD61600025 |
Bibtex: | @article{Schmidt-Erfurth1996, author = {Schmidt Erfurth, U; Birngruber, R and Hasan, T}, title = {Photodynamic therapy in ocular vascular disease}, journal = {Ieee Journal of Selected Topics in Quantum Electronics}, pages = {988-996}, note = {Xd616 Times Cited:5 Cited References Count:57}, abstract = {Photodynamic therapy (PDT) is a novel therapeutical approach which is noninvasive and potentially selective for neoplastic pathologies, Association of photosensitizers with low density lipoprotein (LDL) leads to direct targeting of the treated lesions with enhanced efficiency and selectivity. LDL-mediated PDT is particularly useful in the treatment of neovascular structures since LDL receptors are abundantly expressed on vascular endothelial cells, To evaluate the potential of selective photodynamic vasoocclusion in ocular neovascular disease a sequence of experiments was designed: Efficiency of the LDL-carrier was tested in vitro, the system was then transfered to an in vivo model demonstrating a vascularized neoplasm, Occlusion was successfully performed in experimentally induced neovascularization in the cornea, while selective photothrombosis of subretinal vasculature revealed lack of collateral damage, The experimental results were used to establish a first clinical trial for the use of PDT in age-related macular degeneration, one of the leading causes for blindness.}, keywords = {low-density-lipoprotein receptor activity plasma-lipoproteins singlet oxygen cells-invitro murine tumor hematoporphyrin invivo benzoporphyrin retinoblastoma}, ISSN = {1077-260X}, DOI = {Doi 10.1109/2944.577328}, url = {<Go to ISI>://WOS:A1996XD61600025}, year = {1996}, type = {Journal Article} } |
U.
SchmidtErfurth,
T. J.
Flotte,
E. S.
Gragoudas,
K.
Schomacker, and
T.
Hasan,
Benzoporphyrin-lipoprotein-mediated photodestruction of intraocular tumors, Experimental Eye Research , vol. 62, no. 1, pp. 1-10, 1996.
Benzoporphyrin-lipoprotein-mediated photodestruction of intraocular tumors, Experimental Eye Research , vol. 62, no. 1, pp. 1-10, 1996.
DOI: | DOI 10.1006/exer.1996.0001 |
File: | WOS:A1996TT61200001 |
Bibtex: | @article{Schmidt-Erfurth1996, author = {SchmidtErfurth, U. and Flotte, T. J. and Gragoudas, E. S. and Schomacker, K. and Birngruber, R. and Hasan, T.}, title = {Benzoporphyrin-lipoprotein-mediated photodestruction of intraocular tumors}, journal = {Experimental Eye Research}, volume = {62}, number = {1}, pages = {1-10}, note = {Tt612 Times Cited:22 Cited References Count:43}, abstract = {Benzoporphyrin derivative (BPD), a sensitizer currently in clinical trials, was evaluated for the treatment of experimental Greene melanoma implanted in the rabbit iris. To improve tumor targeting, BPD was complexed with low-density lipoprotein (LDL) representing an endogenous carrier system for BPD as previously described. Twelve tumors were irradiated at a sensitizer dose of 2 mg kg(-1) body weight using a dye laser at 692 nm. Tumor responses were documented by photography, angiography and light and electron microscopy. All tumors treated with 80 J cm(-2) regressed irreversibly. The principal mechanism of tumor necrosis was thrombosis following disruption of endothelial membranes. Ultrastructure data suggested tumor cell damage, although evidence for this being the result of direct PDT-mediated tumor cell death was less clear. These data suggest that BPD-LDL may be used to improve the selectivity of photodynamic tumor therapy possibly by the increased uptake of lipoprotein-delivered sensitizer to neovascular endothelial cells. (C) 1996 Academic Press Limited}, keywords = {photodynamic therapy benzoporphyrin derivative low-density lipoprotein intraocular tumors, in vivo photodynamic therapy plasma-lipoproteins malignant-melanoma cholesterol-metabolism endothelial-cells hematoporphyrin photosensitization photoimmunotherapy biodistribution invitro}, ISSN = {0014-4835}, DOI = {DOI 10.1006/exer.1996.0001}, url = {<Go to ISI>://WOS:A1996TT61200001}, year = {1996}, type = {Journal Article} } |
M.
Novo, and
H.
Diddens,
Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumours, J Photoch Photobio , vol. 34, pp. 143-148, 1996.
Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumours, J Photoch Photobio , vol. 34, pp. 143-148, 1996.
M.
Zwaan,
U.
Behnle,
R.
Engelhardt,
Alfred
Vogel,
W.
Kloess, and
H. D.
Weiss,
In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium., Fortschr Röntgenstr , vol. 164, no. 1, pp. 68-71, 1996.
In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium., Fortschr Röntgenstr , vol. 164, no. 1, pp. 68-71, 1996.
W.
Wetzel,
U.
SchmidtErfurth,
D.
Spiegel,
P.
Jacobi, and
M.
Buhl,
Laser sclerostomy ab externo using a new Er:YAG laser device. A clinical multicenter study - Laser sclerostomy study group, Vision Research , vol. 36, pp. 2414-2414, 1996.
Laser sclerostomy ab externo using a new Er:YAG laser device. A clinical multicenter study - Laser sclerostomy study group, Vision Research , vol. 36, pp. 2414-2414, 1996.
G.
Geerling,
N.
Koop,
I.
Klingemann, and
H.
Laqua,
Laser thermokeratoplasty - Experimental study in minipigs with a cw-IR laser diode, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 304-304, 1996.
Laser thermokeratoplasty - Experimental study in minipigs with a cw-IR laser diode, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 304-304, 1996.
J. Kampmeier,
Laser thermokeratoplasty (LTK): Biomechanical properties and IR-laser induced forces in porcine cornea., Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 301-301, 1996.
Laser thermokeratoplasty (LTK): Biomechanical properties and IR-laser induced forces in porcine cornea., Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 301-301, 1996.
Alfred
Vogel,
R.
Engelhardt,
U.
Behnle, and
U.
Parlitz,
Minimization of cavitation effects in pulsed laser ablation illustrated on laser angioplasty, Appl Phys B , vol. 62, pp. 173-182, 1996.
Minimization of cavitation effects in pulsed laser ablation illustrated on laser angioplasty, Appl Phys B , vol. 62, pp. 173-182, 1996.
R Gerling,
Morphological and biomorphometrical observations on laser thermal keratoplasty. Histological and biomorphometrical examination of the relationship between refractive change and the volume following Cr: Tm: Ho: YAG laser treatment, Ger J ophthalmol , vol. 5(2), pp. 84-91, 1996.
Morphological and biomorphometrical observations on laser thermal keratoplasty. Histological and biomorphometrical examination of the relationship between refractive change and the volume following Cr: Tm: Ho: YAG laser treatment, Ger J ophthalmol , vol. 5(2), pp. 84-91, 1996.
Y.
Pan,
E.
Lankenau,
J.
Welzel, and
R.
Engelhardt,
Optical Coherence - Gated imaging of Biological Tissues, IEEE J Quant Electr , vol. 2, no. 4, pp. 1029-1034, 1996.
Optical Coherence - Gated imaging of Biological Tissues, IEEE J Quant Electr , vol. 2, no. 4, pp. 1029-1034, 1996.
Reginald
Birngruber,
L.
Indorf,
D.
Soultanopoulos,
G.
Dröge,
H.
Eggers, and
U.
SchmidtErfurth,
Photodynamic occlusion of ocular neovascularization: Preclinical evaluation of liposomal zinc phthalocyanine, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 4214-4214, 1996.
Photodynamic occlusion of ocular neovascularization: Preclinical evaluation of liposomal zinc phthalocyanine, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 4214-4214, 1996.
U.
SchmidtErfurth,
J.
Miller,
M.
Sickerberg,
A.
Strong,
U.
Hoehne,
M.
Fsachi,
H.
vandenBerg,
H.
Laqua,
E.
Gragoudas,
L.
Zografos, and
N.
Bressler,
Photodynamic therapy of subfoveal choroidal neovascularization using benzoporphyrin derivative: First results of a multi-center trial, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 580-580, 1996.
Photodynamic therapy of subfoveal choroidal neovascularization using benzoporphyrin derivative: First results of a multi-center trial, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 580-580, 1996.
N.
Koop,
M. N.
AsiyoVogel,
B.
Kaftan, and
R.
Engelhardt,
CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy, Investigative Ophthalmology & Visual Science , vol. 37(3), pp. 305-305, 1996.
CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy, Investigative Ophthalmology & Visual Science , vol. 37(3), pp. 305-305, 1996.
F Wetzel,
Photofragmentation of lens nuclei using the Er: YAG laser: preliminary report of an in vitro study, Ger J ophthalmol , vol. 5(5), pp. 281-284, 1996.
Photofragmentation of lens nuclei using the Er: YAG laser: preliminary report of an in vitro study, Ger J ophthalmol , vol. 5(5), pp. 281-284, 1996.
W.
Wetzel,
N.
Koop, and
F.
Schroer,
Photofragmentation of lens nuclei using the Er:YAG laser: Preliminary report of an in vitro study, Ger J Ophthalmol , vol. 5(5), pp. 281-284, 1996.
Photofragmentation of lens nuclei using the Er:YAG laser: Preliminary report of an in vitro study, Ger J Ophthalmol , vol. 5(5), pp. 281-284, 1996.
File: | 7016223 |
Bibtex: | @article{Wetzel1996, author = {Wetzel, W. and Brinkmann, R. and Koop, N. and Schroer, F. and Birngruber, R.}, title = {Photofragmentation of lens nuclei using the Er:YAG laser: Preliminary report of an in vitro study}, journal = {Ger J Ophthalmol}, volume = {5(5)}, pages = {281-284}, note = {Vq341 Times Cited:13 Cited References Count:12}, abstract = {The energy of the erbium:YAG laser (2,940-nm wave-length) can be used for minimally traumatic photoablation due to its high absorption at the tissue water and its consequently low penetration depth. Laser sclerostomy ab externo, an application of this principle, has undergone advanced clinical investigation. Another potential application is photofragmentation of the lens for cataract extraction. A laboratory model Er: YAG laser (flashlamp-pumped, 200-mu s pulse length, 5-Hz repetition frequency) was coupled to a short low-OH quartz fiber (400 mu m in diameter). The laser energy was applied by direct contact of the fiber tip to human lenses with very dense cataract. The lenses rested in a small cuvette filled with an aqueous-humor-analogous fluid. The fragmentablation rate was evaluated in relation to the number of pulses and the pulse energy. A laser-triggered flash-photography unit was engaged to visualize the ablation dynamics. We found tissue-ablation rates to range from 4 to 19 mu g/pulse, depending on the nucleus density and ulse energy. The maximal size of the removed fragments was always below 500 mu m During ablation, rapidly increasing and collapsing cavitation bubbles were photographed at the distal tip of the application fiber. The impact radius of these cavitation effects markedly exceeded the pure penetration depth of laser radiation at a 2.9-mu m wavelength. A clinical application of the method should be possible as judged by the results obtained for tissue-ablation rate and fragment size. Cavitation-bubble dynamics seems to be responsible for the high fragmentation efficiency. Special application probes have to be developed to optimize ablation and to prevent inadvertent destruction of the posterior lens capsule by cavitation effects.}, keywords = {phacoemulsification er:yag laser cavitation effects ablation surgery}, ISSN = {0941-2921}, url = {https://www.osti.gov/etdeweb/biblio/7016223}, year = {1996}, type = {Journal Article} } |
Alfred
Vogel,
K.
Nahen,
D
Theisen, and
J.
Noack,
Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part I: Optical Breakdown at Threshold and Superthreshold Irradiance., IEEE , vol. 2, no. 4, pp. 847-860, 1996.
Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part I: Optical Breakdown at Threshold and Superthreshold Irradiance., IEEE , vol. 2, no. 4, pp. 847-860, 1996.
K.
Nahen, and
Alfred
Vogel,
Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part II: Transmission, Scattering, and Reflection, IEEE , vol. 2, no. 4, pp. 861-871, 1996.
Plasma Formation in Water by Picosecond and Nanosecond Nd: YAG Laser Pulses - Part II: Transmission, Scattering, and Reflection, IEEE , vol. 2, no. 4, pp. 861-871, 1996.
J.
Roider,
C.
Lindemann,
G.
Dröge, and
E.
ElHifnawi,
Selective RPE-photocoagulation with repetitive 200 ns subthreshold laser pulses, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 3585-3585, 1996.
Selective RPE-photocoagulation with repetitive 200 ns subthreshold laser pulses, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 3585-3585, 1996.
Alfred Vogel,
Shock wave emission and cavitation bubble generation by picosecond and nanosecond optical breakdown in water, J Acoust Soc Am , vol. 100, pp. 148-165, 1996.
Shock wave emission and cavitation bubble generation by picosecond and nanosecond optical breakdown in water, J Acoust Soc Am , vol. 100, pp. 148-165, 1996.
R.
Gillies,
N.
Kollias,
T.
Hasan, and
H.
Diddens,
Spectral characterization of the benzoporphyrin derivative monoacid ring-A photoproduct formed in fetal calf solutions during irradiation with 694 nm continuous-wave radiation, J Photochem Photobiol B , vol. 33, no. 1, pp. 87-90, 1996.
Spectral characterization of the benzoporphyrin derivative monoacid ring-A photoproduct formed in fetal calf solutions during irradiation with 694 nm continuous-wave radiation, J Photochem Photobiol B , vol. 33, no. 1, pp. 87-90, 1996.
R
Koop, and
G
Schirner,
Verwendung des konfokalen Laserscanverfahrens zur Bestimmung der Hornhaut-topographie und der kornealen Gewebseffekte bei der refraktiven Hornhautchirurgie: Hornhaut, Der Ophthalmologe (Berlin. Print) , vol. 93(3), pp. 247-251, 1996.
Verwendung des konfokalen Laserscanverfahrens zur Bestimmung der Hornhaut-topographie und der kornealen Gewebseffekte bei der refraktiven Hornhautchirurgie: Hornhaut, Der Ophthalmologe (Berlin. Print) , vol. 93(3), pp. 247-251, 1996.
A
Knipper,
G
Dröge,
D
Gafumbegete,
A
Miller, and
B
Gromoll,
Ureterotomy with a pulsed Holmium Laser, Proc LASER '95, Springer Verlag , pp. 16-19, 1996.
Ureterotomy with a pulsed Holmium Laser, Proc LASER '95, Springer Verlag , pp. 16-19, 1996.
File: | 978-3-642-80264-5_3 |
Bibtex: | @article{Brinkmann1996-3, author = {Brinkmann, R and Knipper, A and Dröge, G and Gafumbegete, D and Miller, A and Gromoll, B and Birngruber, R}, title = {Ureterotomy with a pulsed Holmium Laser}, journal = {Proc LASER '95, Springer Verlag}, pages = {16-19}, year = { 1996}, url = { https://link.springer.com/chapter/10.1007/978-3-642-80264-5_3}, type = {Journal Article} } |
N.
Koop,
K.
Kamm,
G.
Geerling, and
J.
Kampmeier,
Laser thermokeratoplasty: an in vitro and in vivo-study by means of a Continous Wave Mid-IR laser diode., Lasermedizin , vol. 12, pp. 179-186, 1996.
Laser thermokeratoplasty: an in vitro and in vivo-study by means of a Continous Wave Mid-IR laser diode., Lasermedizin , vol. 12, pp. 179-186, 1996.
J Brinkmann,
Laser Thermokeratoplasty: an in vitro and in vivo study by means of a cw mid-IR laser diode, Laser Medizin , vol. 12, pp. 179-186, 1996.
Laser Thermokeratoplasty: an in vitro and in vivo study by means of a cw mid-IR laser diode, Laser Medizin , vol. 12, pp. 179-186, 1996.
File: | 978-3-642-60306-8_83 |
Bibtex: | @article{Brinkmann1996-2, author = {Brinkmann, R;Koop, N;Kamm, K;Geerling, G;Kampmeier, J and Birngruber, R}, title = {Laser Thermokeratoplasty: an in vitro and in vivo study by means of a cw mid-IR laser diode}, journal = {Laser Medizin}, volume = {12}, Keywords = {Brechkraftänderung, Denaturierung, Hyperopie-Korrektur, Koagulation, Kollagen-Kontraaktion, Kornea, Temperaturberechnung}, pages = {179-186}, year = { 1996}, url = { https://doi.org/10.1007/978-3-642-60306-8_83}, type = {Journal Article} } |
Gerd
Gerling,
Alfred
Vogel,
E.
ElHifnawi,
N.
Koop, and
G.
Dröge,
Morphological and biomorphometrical observations on laser thermal keratoplasty - Histological and biomorphometrical examination of the relationship between refractive change and the volume of laser thermal keratoplasty lesions following Cr:Tm:Ho:YAG laser treatment, German Journal of Ophthalmology , vol. 5, no. 2, pp. 84-91, 1996.
Morphological and biomorphometrical observations on laser thermal keratoplasty - Histological and biomorphometrical examination of the relationship between refractive change and the volume of laser thermal keratoplasty lesions following Cr:Tm:Ho:YAG laser treatment, German Journal of Ophthalmology , vol. 5, no. 2, pp. 84-91, 1996.
1995
R.
Goldau,
H.
Twilfer,
M.
Zwaan,
M.
Morrin, and
U.
Marquardt,
In-vivo fluorescence spectroscopy of abdominal and iliac arterial in humans., Lasermedizin , vol. 11, pp. 212-218, 1995.
In-vivo fluorescence spectroscopy of abdominal and iliac arterial in humans., Lasermedizin , vol. 11, pp. 212-218, 1995.
Y.
Pan,
J.
Rosperich, and
R.
Engelhardt,
Low-coherence optical tomography in turbid tissue: theoretical analysis., Appl Optics , vol. 34, no. 28, pp. 6564-6574, 1995.
Low-coherence optical tomography in turbid tissue: theoretical analysis., Appl Optics , vol. 34, no. 28, pp. 6564-6574, 1995.
F.
Schroer,
D.
Mohrenstecher,
G.
Dröge,
Ralf
Brinkmann, and
Reginald
Birngruber,
Ablation Dynamics in Laser Sclerostomy Ab-Externo, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S558-S558, 1995.
Ablation Dynamics in Laser Sclerostomy Ab-Externo, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S558-S558, 1995.
A.
Reichle,
H.
Diddens,
F.
Altmayr,
J.
Rastetter, and
R.
Andreesen,
Beta-tubulin and P-glycoprotein: Major determinants of vincristine accumulation in B-CLL cells, Leuk Res , vol. 19, no. 11, pp. 823-829, 1995.
Beta-tubulin and P-glycoprotein: Major determinants of vincristine accumulation in B-CLL cells, Leuk Res , vol. 19, no. 11, pp. 823-829, 1995.
J.
Roider,
U.
SchmidtErfurth,
H.
Hoerauf,
T.
Lasser, and
H.
Laqua,
Contact Diode-Laser Cyclophotocoagulation (Cpc) with a New Focusing Fiber Tip, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S559-S559, 1995.
Contact Diode-Laser Cyclophotocoagulation (Cpc) with a New Focusing Fiber Tip, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S559-S559, 1995.
C. A.
Toth,
S. A.
Boppart,
M. R.
Hee,
C. D.
DiCarlo,
C. P.
Cain, and
W. P.
Roach,
Correlation between Optical Coherence Tomography, Clinical Examination and Histopathology of Macular Laser Lesions, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S207-S207, 1995.
Correlation between Optical Coherence Tomography, Clinical Examination and Histopathology of Macular Laser Lesions, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S207-S207, 1995.
W.
Wetzel,
R.
Otto,
W.
Falkenstein, and
U.
Schmidt-Erfurth,
Development of a new Er: YAG laser conception for laser sclerostomy ab externo: experimental and first clinical results, Ger J Ophthalmol , vol. 4, no. 5, pp. 283-8, 1995.
Development of a new Er: YAG laser conception for laser sclerostomy ab externo: experimental and first clinical results, Ger J Ophthalmol , vol. 4, no. 5, pp. 283-8, 1995.
File: | query.fcgi |
Bibtex: | @article{Wetzel1995, author = {Wetzel, W. and Otto, R. and Falkenstein, W. and Schmidt-Erfurth, U. and Birngruber, R.}, title = {Development of a new Er: YAG laser conception for laser sclerostomy ab externo: experimental and first clinical results}, journal = {Ger J Ophthalmol}, volume = {4}, number = {5}, pages = {283-8}, note = {0941-2921 (Print) Journal Article}, abstract = {The erbium:YAG laser is a preferable energy source for laser sclerostomy ab externo due to the high absorption of its radiation (2940-nm wavelength) in the aqueous parts of scleral tissue. It has thus far been a disadvantage that laser energy has to be transmitted from the laser source to the application site via very susceptible special optical fibers (ZrF). As a consequence of technical improvements, the laser source could be integrated into the application probe. Therefore, only a robust quartz fiber was necessary for contact application. A fiber diameter of 400 microns was chosen according to the experience gained in previous studies. A total of 24 eyes with chronical open-angle glaucoma were treated. A fistula end-point detection unit was developed for safe indication of a full-thickness perforation of the sclera. With a fiber diameter of 400 microns, a postoperative success rate of about 54% was achieved at 6 months follow-up. The automated full-thickness perforation detection prevented the application of additional, surplus laser pulses in the anterior chamber. The postoperative success rate could be improved over that achieved in previous studies. The new device/conception offers more technical reliability and is a further step toward minimally invasive fistulating laser surgery of open-angle glaucoma.}, keywords = {Erbium Follow-Up Studies Glaucoma, Open-Angle/*surgery Humans Laser Surgery/instrumentation/*methods Sclera/*surgery Treatment Outcome}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7496339}, year = {1995}, type = {Journal Article} } |
G.
Schirner,
G.
Dröge,
N.
Koop, and
E. S.
Elhifnawi,
Experimental Studies to Optimize Laser-Thermokeratoplasty Using Pulsed and Cw-Laser-Sources, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S716-S716, 1995.
Experimental Studies to Optimize Laser-Thermokeratoplasty Using Pulsed and Cw-Laser-Sources, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S716-S716, 1995.
G.
Schirner,
N.
Koop, and
E.
ElHifnawi,
Experiments with Pulsed and Continuous-Wave Laser Sources to Optimize Laserthermo-Keratoplasty, Vision Research , vol. 35, pp. P167-P167, 1995.
Experiments with Pulsed and Continuous-Wave Laser Sources to Optimize Laserthermo-Keratoplasty, Vision Research , vol. 35, pp. P167-P167, 1995.
U.
SchmidtErfurth,
T.
Hasan,
K.
Schomacker, and
T.
Flotte,
In-Vivo Uptake of Liposomal Benzoporphyrin Derivative and Photothrombosis in Experimental Corneal Neovascularization, Lasers in Surgery and Medicine , vol. 17, no. 2, pp. 178-188, 1995.
In-Vivo Uptake of Liposomal Benzoporphyrin Derivative and Photothrombosis in Experimental Corneal Neovascularization, Lasers in Surgery and Medicine , vol. 17, no. 2, pp. 178-188, 1995.
DOI: | DOI 10.1002/lsm.1900170207 |
File: | WOS:A1995RW60700006 |
Bibtex: | @article{Schmidt-Erfurth1995, author = {Schmidterfurth, U. and Hasan, T. and Schomacker, K. and Flotte, T. and Birngruber, R.}, title = {In-Vivo Uptake of Liposomal Benzoporphyrin Derivative and Photothrombosis in Experimental Corneal Neovascularization}, journal = {Lasers in Surgery and Medicine}, volume = {17}, number = {2}, pages = {178-188}, note = {Rw607 Times Cited:72 Cited References Count:39}, abstract = {Background and Objective: Photodynamic therapy (PDT) has been used successfully to occlude neovascularizations experimentally. We evaluated the vasoocclusive potential of benzoporphyrin derivative (BPD), a new photosensitizer currently in clinical trials. Since liposomally formulated BPD strongly binds to endogenous low density lipoproteins (LDL) after i.v. injection, LDL act as carrier to deliver BPD preferentially 60 proliferating endothelial cells. Study Design/Materials and Methods: Corneal neovascularizations in rabbits were used as model. Time-dependent uptake and retention of liposomal BPD were measured in vivo by monitoring the laser-induced fluorescence (LIF). Photothrombosis was induced using a dye laser emitting at 692 nm. Results: A maximal BPD concentration was measured at 60-90 minutes postinjection determining the optimal time interval for treatment. Exposures as low as 10 J/cm(2) allowed complete and irreversible neovascular occlusion as documented angiographically. Histology revealed selective endothelial damage, adjacent corneal stroma, or iris vessels, remained intact. Identical results were obtained using BPD directly complexed with LDL suggesting use of a LDL-mediated pathway. Conclusion: We suggest BPD-PDT for a selective treatment of neovascular diseases. (C) 1995 Wiley-Liss, Inc.}, keywords = {benzoporphyrin derivative ocular photothrombosis liposomes cornea neovascularization low-density lipoprotein photodynamic therapy laser photocoagulation photochemical initiation vascular occlusion lipid keratopathy endothelial-cells feeder vessels thrombosis hematoporphyrin}, ISSN = {0196-8092}, DOI = {DOI 10.1002/lsm.1900170207}, url = {<Go to ISI>://WOS:A1995RW60700006}, year = {1995}, type = {Journal Article} } |
W.
Wetzel,
U.
Schmidt-Erfurth,
G.
Haring,
J.
Roider, and
G.
Dröge,
Laser sclerostomy ab externo using two different infrared lasers: a clinical comparison, Ger J Ophthalmol , vol. 4, no. 1, pp. 1-6, 1995.
Laser sclerostomy ab externo using two different infrared lasers: a clinical comparison, Ger J Ophthalmol , vol. 4, no. 1, pp. 1-6, 1995.
File: | query.fcgi |
Bibtex: | @article{Wetzel1995, author = {Wetzel, W. and Schmidt-Erfurth, U. and Haring, G. and Roider, J. and Droge, G. and Birngruber, R.}, title = {Laser sclerostomy ab externo using two different infrared lasers: a clinical comparison}, journal = {Ger J Ophthalmol}, volume = {4}, number = {1}, pages = {1-6}, note = {0941-2921 (Print) Comparative Study Journal Article}, abstract = {This study was designed to compare the clinical results of an ab externo approach to laser sclerostomy using two different laser sources under identical conditions. A pulsed (200 microseconds) erbium-YAG laser (lambda = 2940 nm) and a pulsed (200 microseconds) holmium:YAG laser (lambda = 2120 nm) were used. The energy of each laser was transmitted via a fiber (300 microns in diameter) and applied near the limbus, with the fiber tip remaining in steady contact with the sclera. According to the higher tissue absorption coefficient, a shorter penetration depth and, therefore, fewer complications were expected for the Er:YAG laser. A total of 26 patients with advanced open-angle glaucoma were treated and followed for up to 6 months. In all cases a functioning fistula with a prominent filtering bleb and a marked reduction in the intraocular pressure (from up to 35 mm Hg to < 10 mm Hg) could be achieved primarily. The total energy required was about 4 times lower for erbium:YAG laser was compared with holmium:YAG laser sclerostomies. No complication occurred intraoperatively. Postoperatively, reversible adherence of the iris to the internal ostium was more frequently observed in Ho:YAG laser sclerostomies (60%) and small hyphemas were more often seen in Er:YAG laser sclerostomies (30%). After 6 months of follow-up, about 40% of the fistula remained patent in both groups. In principle, both lasers are suited to serve as energy sources for the described approach. Under the conditions of the present study, different levels of thermal effects did not cause any significant difference in the clinical success rate.(ABSTRACT TRUNCATED AT 250 WORDS)}, keywords = {Adult Chronic Disease Follow-Up Studies Glaucoma, Open-Angle/*surgery Humans Intraocular Pressure Laser Surgery/*methods Middle Aged Ostomy Postoperative Complications Prognosis Sclera/surgery *Sclerostomy}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7728103}, year = {1995}, type = {Journal Article} } |
W Schmidterfurth,
Mitomycin-C in Laser Sclerostomy - Time of Administration and Postoperative Hypotony, Invest Ophthal & VisScie , pp. S89-S89, 1995.
Mitomycin-C in Laser Sclerostomy - Time of Administration and Postoperative Hypotony, Invest Ophthal & VisScie , pp. S89-S89, 1995.
J.
Inderfurth,
R. D.
Ferguson,
C. A.
Puliafito, and
M. B.
Frish,
Reflection measurement during retinal laser coagulation in patients. Development of an automatically controlled dosimeter, Ophthalmologe , vol. 92, no. 5, pp. 717-22, 1995.
Reflection measurement during retinal laser coagulation in patients. Development of an automatically controlled dosimeter, Ophthalmologe , vol. 92, no. 5, pp. 717-22, 1995.
File: | query.fcgi |
Bibtex: | @article{Inderfurth1995, author = {Inderfurth, J. and Ferguson, R. D. and Puliafito, C. A. and Frish, M. B. and Birngruber, R.}, title = {[Reflection measurement during retinal laser coagulation in patients. Development of an automatically controlled dosimeter]}, journal = {Ophthalmologe}, volume = {92}, number = {5}, pages = {717-22}, note = {0941-293X (Print) English Abstract Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.}, abstract = {PURPOSE: Retinal laser coagulation has limited reproducibility, because every laser exposition is unpredictably affected by pigmentation and media opacities. This can lead to complications. A feedback-controlled dosimeter would make retinal laser treatment a safer, more reproducible and faster procedure. METHOD: A reflectometer was developed that allows monitoring of the reflection of laser light during standard photocoagulation. Hundreds of coagulations in rabbit eyes and about 12,000 coagulations in patients undergoing routine laser treatment were recorded. RESULTS: The results of the first reflectance measurements in humans are presented along with extensive animal studies. A typical reflectance history was found for different lesion intensities. The degree of retinal whitening correlates with reflectance characteristics. These characteristics allow an early prediction of lesion intensity. Motion during laser exposure affects each coagulation in a fashion similar to spot size and exposure time. CONCLUSION: Reflectometry is the currently most effective means of monitoring lesion development. An automatic dosimeter for retinal photocoagulation seems feasible.}, keywords = {Animals Equipment Design Feasibility Studies Humans Laser Coagulation/*instrumentation Rabbits Radiotherapy Planning, Computer-Assisted/*instrumentation Retinal Diseases/*surgery Treatment Outcome}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8751004}, year = {1995}, type = {Journal Article} } |
1994
J. H. C.
Inderfurth,
R. D.
Ferguson,
C. A.
Puliafito,
M. B.
Frish, and
Reginald
Birngruber,
Reflectance Monitoring during Retinal Photocoagulation in Humans - Steps toward the Development of an Automated Feedback-Controlled Photocoagulator, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 1374-1374, 1994.
Reflectance Monitoring during Retinal Photocoagulation in Humans - Steps toward the Development of an Automated Feedback-Controlled Photocoagulator, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 1374-1374, 1994.
Alfred
Vogel, and
K.
Jungnickel,
Mechanisms of intraocular photodisruption with picosecond and nanosecond laser pulses, Lasers Surg Med , vol. 15, no. 1, pp. 32-43, 1994.
Mechanisms of intraocular photodisruption with picosecond and nanosecond laser pulses, Lasers Surg Med , vol. 15, no. 1, pp. 32-43, 1994.
R
Schmidt Erfurth,
Reginald
Birngruber, and
T
Hasan,
Photodynamic Therapy of Experimental Choroidal Melanoma Using Lipoprotein-Delivered Benzoporphyrin, Ophthal , pp. 89-99, 1994.
Photodynamic Therapy of Experimental Choroidal Melanoma Using Lipoprotein-Delivered Benzoporphyrin, Ophthal , pp. 89-99, 1994.
K.
Ludwig,
L. C.
Busch,
K.
Jungnickel, and
Alfred
Vogel,
Präparation critical-point-getrockneter Mausembryonen mit einem Laserskalpell, Ann Anat , vol. 176, pp. 559 - 563, 1994.
Präparation critical-point-getrockneter Mausembryonen mit einem Laserskalpell, Ann Anat , vol. 176, pp. 559 - 563, 1994.
J. H.
Inderfurth,
R. D.
Ferguson,
M. B.
Frish, and
Reginald
Birngruber,
Dynamic reflectometer for control of laser photocoagulation on the retina, Lasers Surg Med , vol. 15, no. 1, pp. 54-61, 1994.
Dynamic reflectometer for control of laser photocoagulation on the retina, Lasers Surg Med , vol. 15, no. 1, pp. 54-61, 1994.
File: | query.fcgi |
Bibtex: | @article{Inderfurth1994, author = {Inderfurth, J. H. and Ferguson, R. D. and Frish, M. B. and Birngruber, R.}, title = {Dynamic reflectometer for control of laser photocoagulation on the retina}, journal = {Lasers Surg Med}, volume = {15}, number = {1}, pages = {54-61}, note = {0196-8092 (Print) Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.}, abstract = {In retinal laser photocoagulation, constant exposure parameters do not result in identical lesions. This lack of reproducibility increases the rate of complications from over- or undertreatment and inhibits determination of the optimal treatment endpoints for different retinal disorders. To this end, a feedback-controlled photocoagulator could make retinal photocoagulation a safer, more reproducible, and faster procedure. A dynamic confocal reflectometer was integrated into a slit lamp laser delivery system. Real-time reflectance changes on the retinas of pigmented rabbits were obtained by monitoring the increasing back-scattered light of the coagulating beam during argon laser photocoagulation. Reproducible temporal reflectance patterns were measured that correlated with ophthalmoscopically assessed lesion intensity independent of the exposure parameters, the transparency of the optical media, and the focusing conditions. As a step toward the development of a feedback-controlled photocoagulator, the confocal reflectometer has been proven in animal trials closely resembling clinical practice.}, keywords = {Animals Laser Coagulation/*instrumentation/methods Rabbits Retina/*surgery}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7997048}, year = {1994}, type = {Journal Article} } |
J.
Roider,
M.
Schiller,
E. S.
Hifnawi, and
Reginald
Birngruber,
Retinal photocoagulation with a pulsed, frequency-doubled Nd:YAG laser (532 nm), Ophthalmologe , vol. 91, no. 6, pp. 777-82, 1994.
Retinal photocoagulation with a pulsed, frequency-doubled Nd:YAG laser (532 nm), Ophthalmologe , vol. 91, no. 6, pp. 777-82, 1994.
File: | query.fcgi |
Bibtex: | @article{Roider1994, author = {Roider, J. and Schiller, M. and el Hifnawi, E. S. and Birngruber, R.}, title = {[Retinal photocoagulation with a pulsed, frequency-doubled Nd:YAG laser (532 nm)]}, journal = {Ophthalmologe}, volume = {91}, number = {6}, pages = {777-82}, note = {0941-293X (Print) Comparative Study English Abstract Journal Article}, abstract = {The small difference in wavelength between an argon laser (514 nm) and a frequency-doubled Nd:YAG laser (532 nm), together with the advantage of the solid-state technology, makes the Nd:YAG laser likely to play a major role in retinal photocoagulation in the near future. For technical reasons all frequency-doubled Nd:YAG lasers work in a quasi-continuous mode, emitting a burst of highly repetitive short laser pulses during the exposure time desired. We investigated the side effects due to high peak irradiances of those short laser pulse trains (Crystal Focus Nd:YAG laser, Emerald; pulse duration 1-10 microseconds, repetition rate 13 KHz) in rabbits in comparison with a standard argon laser system (Zeiss, Visulas, Argon II). The energy necessary for blanching the retina was similar in both cases. As opposed to the argon laser system, subretinal bubbles were regularly visible ophthalmoscopically with the Nd:YAG system, when average powers as high as 200 mW were used. The ED50 power for bubble formation is about 2-3 times above the ED50 power for blanching. Thermal calculations show that this bubble formation effect is likely to be related to the peak power of the short pulses. The hemorrhage threshold is similar in both systems. However, light microscopically there is no difference between the two laser systems. Panretinal photocoagulation (300-500 microns, 100-200 ms) in patients with proliferative diabetic retinopathy produced such bubbles about once per 1000 lesions.}, keywords = {Animals Diabetic Retinopathy/pathology/surgery Equipment Design Humans Laser Coagulation/*instrumentation Light Coagulation/*instrumentation Microscopy, Electron Ophthalmoscopy Rabbits Retina/injuries/pathology/*surgery Retinal Hemorrhage/pathology Vitreoretinopathy, Proliferative/pathology/surgery}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7849431}, year = {1994}, type = {Journal Article} } |
J.
Roider,
J.
Traccoli,
N.
Michaud,
T.
Flotte,
R.
Anderson, and
Reginald
Birngruber,
Selektiver Gefässverschluss durch repetierende kurze Laserpulse, Ophthalmologe , vol. 91, no. 3, pp. 274-9, 1994.
Selektiver Gefässverschluss durch repetierende kurze Laserpulse, Ophthalmologe , vol. 91, no. 3, pp. 274-9, 1994.
File: | query.fcgi |
Bibtex: | @article{Roider1994, author = {Roider, J. and Traccoli, J. and Michaud, N. and Flotte, T. and Anderson, R. and Birngruber, R.}, title = {Selektiver Gefässverschluss durch repetierende kurze Laserpulse}, journal = {Ophthalmologe}, volume = {91}, number = {3}, pages = {274-9}, note = {0941-293X (Print) English Abstract Journal Article}, abstract = {The occlusion of arterioles and venules (30 microns in diameter) by means of repeated dye laser pulses (577 nm, 160 microseconds, 0.5 Hz) was studied in the hamster cheek pouch model. Microscopically visible changes during and after irradiation were recorded and monitored by a video system. The energy necessary per pulse for vessel occlusion with a single pulse (arterioles 5 J/cm2, venules 3.5 J/cm2) can be lowered more than 50% with 100 pulses (1.8 J/cm2, 1.2 J/cm2). Rupture of vessels, which regularly occurs with a single pulse, can be totally avoided with 100 repetitive laser pulses. Investigations of the temperature dependence of the occlusion rate of arterioles showed different interaction mechanisms with one pulse and 100 pulses (mechanical and thermal respectively). Light and electron microscopic investigations supported this concept of selective occlusion using repeated short laser pulses. Possible clinical applications are portwine stains of the eyelid, neovascularisation on the cornea and subretinal neovascularisation.}, keywords = {Animals Arterioles/pathology Cheek/blood supply Cricetinae *Disease Models, Animal Light Coagulation/*instrumentation Microscopy, Electron Retinal Neovascularization/pathology/*surgery Venules/pathology Video Recording/*instrumentation}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8086741}, year = {1994}, type = {Journal Article} } |
B
Knipper,
D
Jocham, and
Ralf
Brinkmann,
The Holmium-YAG-laser as a new cutting instrument in the ureter, Investigative urology (Berlin, Germany) , vol. 5, pp. 233-235, 1994.
The Holmium-YAG-laser as a new cutting instrument in the ureter, Investigative urology (Berlin, Germany) , vol. 5, pp. 233-235, 1994.
U.
Schmidt-Erfurth,
T.
Hasan,
E.
Gragoudas,
N.
Michaud,
T. J.
Flotte, and
Reginald
Birngruber,
Vascular targeting in photodynamic occlusion of subretinal vessels, Ophthalmology , vol. 101, no. 12, pp. 1953-61, 1994.
Vascular targeting in photodynamic occlusion of subretinal vessels, Ophthalmology , vol. 101, no. 12, pp. 1953-61, 1994.
File: | query.fcgi |
Bibtex: | @article{Schmidt-Erfurth1994, author = {Schmidt-Erfurth, U. and Hasan, T. and Gragoudas, E. and Michaud, N. and Flotte, T. J. and Birngruber, R.}, title = {Vascular targeting in photodynamic occlusion of subretinal vessels}, journal = {Ophthalmology}, volume = {101}, number = {12}, pages = {1953-61}, note = {0161-6420 (Print) Journal Article Research Support, Non-U.S. Gov't}, abstract = {PURPOSE: To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateral damage of PDT-induced photothrombosis in the rabbit choriocapillary layer. METHOD: Benzoporphyrin derivative, a new photosensitizer, currently in clinical trials for tumor therapy, was used. Low-density lipoprotein served as a carrier to enhance selective targeting of vascular endothelial cells. RESULTS: Complete choriocapillary occlusion was achieved at a BPD dose of 2 mg/kg and a radiant exposure as low as 10 J/cm2. When PDT was performed 3 hours after BPD application, damage to the neural retina was minimal. Only inner photoreceptor segments showed mitochondrial swelling probably secondary to choroidal ischemia. Bruch's membrane remained intact. Retinal pigment epithelium was invariably damaged as seen with other photosensitizers. CONCLUSION: Compared with photocoagulation BPD-PDT allows endothelial-bound intraluminal photothrombosis, sparing important structures such as neural retina and Bruch's membrane. It may thus provide a more selective treatment of juxtafoveal and subfoveal neovascular membranes.}, keywords = {Animals Bruch Membrane/drug effects/pathology/radiation effects Choroid/blood supply Drug Carriers Endothelium, Vascular/drug effects/pathology/radiation effects Lipoproteins, LDL/therapeutic use *Photochemotherapy/methods Photoreceptors/drug effects/pathology/radiation effects Pigment Epithelium of Eye/drug effects/pathology/radiation effects Porphyrins/administration & dosage/*therapeutic use Rabbits Radiation-Sensitizing Agents/administration & dosage/*therapeutic use Retinal Neovascularization/*drug therapy/pathology Retinal Vessels/*drug effects/pathology/radiation effects}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7997334}, year = {1994}, type = {Journal Article} } |
R
Wetzel,
Ralf
Brinkmann, and
Reginald
Birngruber,
Laser sclerostomy ab externo using the erbium: YAG laser. First results of a clinical study, Germ j ophthal , vol. 3(2), no. 2, pp. 112-115, 1994.
Laser sclerostomy ab externo using the erbium: YAG laser. First results of a clinical study, Germ j ophthal , vol. 3(2), no. 2, pp. 112-115, 1994.
File: | query.fcgi |
Bibtex: | @article{Brinkmann1994, author = {Wetzel, W;Häring, G;Brinkmann, R and Birngruber, R}, title = {Laser sclerostomy ab externo using the erbium: YAG laser. First results of a clinical study}, journal = {Germ j ophthal}, volume = {3(2)}, pages = {112-115}, ISSN = {0941-2921}, year = {1994}, type = {Journal Article} } |
H. J.
Hettlich,
K.
Lucke,
M. N.
Asiyo-Vogel,
M.
Schulte, and
Alfred
Vogel,
Lens refilling and endocapsular polymerization of an injectable intraocular lens: in vitro and in vivo study of potential risks and benefits, J Cataract Refract Surg , vol. 20, no. 2, pp. 115-23, 1994.
Lens refilling and endocapsular polymerization of an injectable intraocular lens: in vitro and in vivo study of potential risks and benefits, J Cataract Refract Surg , vol. 20, no. 2, pp. 115-23, 1994.
M. R.
Hee,
J. A.
Izatt,
E. A.
Swanson,
D.
Huang,
C. P.
Lin,
C. A.
Puliafito,
J.
Inderfurth,
Reginald
Birngruber, and
James G.
Fujimoto,
In-Vivo Optical Coherence Tomography of the Anterior Segment, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 2078-2078, 1994.
In-Vivo Optical Coherence Tomography of the Anterior Segment, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 2078-2078, 1994.
Ralf
Brinkmann,
G.
Dröge,
N.
Koop,
A.
Wördemann,
G.
Schirner, and
Reginald
Birngruber,
Investigations on laser thermokeratoplasty, Lasers Light Ophthalmol , vol. 6, no. 4, pp. 259 - 270, 1994.
Investigations on laser thermokeratoplasty, Lasers Light Ophthalmol , vol. 6, no. 4, pp. 259 - 270, 1994.
Alfred
Vogel,
M.
AsiyoVogel, and
Reginald
Birngruber,
Investigations on Intrastromal Refractive Surgery with Picosecond Nd-Yag Laser-Pulses, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 2155-2155, 1994.
Investigations on Intrastromal Refractive Surgery with Picosecond Nd-Yag Laser-Pulses, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 2155-2155, 1994.
Alfred
Vogel,
M.
Asiyo-Vogel, and
Reginald
Birngruber,
Intrastromal refractive corneal surgery with pico-second Nd:YAG laser pulses, Ophthalmologe , vol. 91, no. 5, pp. 655-62, 1994.
Intrastromal refractive corneal surgery with pico-second Nd:YAG laser pulses, Ophthalmologe , vol. 91, no. 5, pp. 655-62, 1994.
File: | query.fcgi |
Bibtex: | @article{Vogel1994, author = {Vogel, Alfred and Asiyo-Vogel, M. and Birngruber, R.}, title = {[Intrastromal refractive corneal surgery with pico-second Nd:YAG laser pulses]}, journal = {Ophthalmologe}, volume = {91}, number = {5}, pages = {655-62}, note = {0941-293X (Print) English Abstract Journal Article Research Support, Non-U.S. Gov't}, abstract = {Intrastromal laser surgery with picosecond pulses aims to achieve refractive changes of the cornea without damaging the epithelium, Bowman's membrane, or the endothelium. For that, a tissue layer with well-defined thickness has to be evaporated by creating laser plasmas within the corneal stroma. We investigated the plasma formation and the plasma-induced shock wave emission and bubble generation (cavitation) in the cornea, as well as the tissue effects and the range for endothelial damage. The laser light source used was an Nd:YAG laser emitting pulses with a duration of 30 ps at a repetition rate of 10 Hz. Intrastromal plasma formation and cavitation were investigated in sheep eyes in vitro by means of time-resolved macro-photography with 20 ns exposure time. Photographs were taken at various delay times (3 microseconds-2 min) after the release of the Nd:YAG laser pulse. The morphology of the laser effects and the incidence of endothelial damage was investigated by light-microscopic inspection of histological cross sections of the irradiated corneas. The minimal plasma size at energies close to the breakdown threshold was about 40 microns. Using a laser effects could be created without causing microscopically detectable damage to the epithelium, endothelium, or Bowman's membrane. To avoid damage, the distance between endothelium and laser focus had to be larger than 150 microns. Shock wave-induced tissue damage was not observed, although the maximum shock wave pressure was up to 13 kbar. The laser-generated intrastromal cavities are at least 10 times larger than the plasma volume.(ABSTRACT TRUNCATED AT 250 WORDS)}, keywords = {Animals Corneal Stroma/pathology/*surgery Endothelium, Corneal/pathology Epithelium/pathology Equipment Design Laser Surgery/*instrumentation *Refraction, Ocular Sheep Surface Properties}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7812100}, year = {1994}, type = {Journal Article} } |
Alfred
Vogel,
M. R.
Capon, and
M.
Asiyo-Vogel,
Intraocular photodisruption with picosecond and nanosecond laser pulses: tissue effects in cornea, lens, and retina, Invest Ophthalmol Vis Sci , vol. 35, no. 7, pp. 3032-44, 1994.
Intraocular photodisruption with picosecond and nanosecond laser pulses: tissue effects in cornea, lens, and retina, Invest Ophthalmol Vis Sci , vol. 35, no. 7, pp. 3032-44, 1994.
C. P.
Lin,
Y. K.
Weaver,
Reginald
Birngruber,
James G.
Fujimoto, and
C. A.
Puliafito,
Intraocular microsurgery with a picosecond Nd:YAG laser, Lasers Surg Med , vol. 15, no. 1, pp. 44-53, 1994.
Intraocular microsurgery with a picosecond Nd:YAG laser, Lasers Surg Med , vol. 15, no. 1, pp. 44-53, 1994.
File: | query.fcgi |
Bibtex: | @article{Lin1994, author = {Lin, C. P. and Weaver, Y. K. and Birngruber, R. and Fujimoto, J. G. and Puliafito, C. A.}, title = {Intraocular microsurgery with a picosecond Nd:YAG laser}, journal = {Lasers Surg Med}, volume = {15}, number = {1}, pages = {44-53}, note = {0196-8092 (Print) Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.}, abstract = {We investigated the use of picosecond Nd:YAG laser pulses for intraocular microsurgery. With a pulse duration of 100 picoseconds, only 70 microJ of pulse energy is required to consistently produce optical breakdown in the deep vitreous. This pulse energy is nearly two orders of magnitude less than the typical pulse energies used in conventional (nanosecond) photodisruptors. The reduced pulse energy results in a smaller zone of tissue damage, an important consideration when operating close to the retina or other sensitive ocular structures. Efficient cutting action is achieved by applying multiple pulses at a moderately high repetition rate of 50-200 Hz. An in vitro model was developed to assess axial confinement of picosecond photodisruption. In vivo vitreous membrane surgery was performed in experimental rabbit eyes to demonstrate a potential clinical application of picosecond laser-induced optical breakdown.}, keywords = {3T3 Cells Animals Cell Membrane Cells, Cultured Disease Models, Animal Eye Diseases/pathology/surgery Laser Surgery/instrumentation/*methods Mice Microsurgery/instrumentation/*methods Rabbits Vitreous Body/pathology/*surgery}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7997047}, year = {1994}, type = {Journal Article} } |
R
Schirner,
Reginald
Birngruber, and
Ralf
Brinkmann,
Experimentelle Untersuchungen zur Wirkung des Er: Glas-und Cr: TM: Ho: YAG-Lasers bei der Thermokeratoplastik, Der Ophthalmologe (Berlin. Print) , vol. 91, no. 5, pp. 638-645, 1994.
Experimentelle Untersuchungen zur Wirkung des Er: Glas-und Cr: TM: Ho: YAG-Lasers bei der Thermokeratoplastik, Der Ophthalmologe (Berlin. Print) , vol. 91, no. 5, pp. 638-645, 1994.
G.
Schirner,
A.
Huber,
A.
Wördemann,
G.
Dröge,
E.
el-Hifnawi,
Reginald
Birngruber, and
Ralf
Brinkmann,
Experimental studies on the effect of the Er:glass and Cr:Tm:Ho:YAG laser in thermokeratoplasty, Ophthalmologe , vol. 91, no. 5, pp. 638-45, 1994.
Experimental studies on the effect of the Er:glass and Cr:Tm:Ho:YAG laser in thermokeratoplasty, Ophthalmologe , vol. 91, no. 5, pp. 638-45, 1994.
File: | query.fcgi |
Bibtex: | @article{Schirner1994, author = {Schirner, G. and Huber, A. and Wordemann, A. and Droge, G. and el-Hifnawi, E. and Birngruber, R. and Brinkmann, R.}, title = {[Experimental studies on the effect of the Er:glass and Cr:Tm:Ho:YAG laser in thermokeratoplasty]}, journal = {Ophthalmologe}, volume = {91}, number = {5}, pages = {638-45}, note = {0941-293X (Print) English Abstract Journal Article}, abstract = {So far the dose-effect ratio of the Holmium laser (wavelength 2.12 microns) and the erbium laser (1.54 microns) for laser thermokeratoplasty (LTK) are not defined in detail. Our study was designed not only to compare the erbium contact and the holmium non-contact applications but also to throw light on the influence of different geometrical application patterns, pulse energies, pulses per coagulation site and repetition rates under experimental conditions. Enucleated sheep and pig eyes were used 2-6 h post mortem, pressurized to 25 mmHg and moisturized with saline solution. Before and after LTK, pachymetry and keratometry were performed. Some specimens were prepared for light and scanning microscopy. The coagulation threshold for the erbium laser in a contact mode with a 200-microns fibre was 25 J/cm2 (ca. 8 mJ/pulse) and for the holmium laser 8 J/cm2 (ca. 2.5 mJ/pulse). The erbium laser was used in a single shot per spot mode, the holmium laser in repeated pulse per spot mode. With the single shot per spot mode, we were able to induce a promising hyperopic shift of up to -3.47 +/- 0.61 D, while myopic changes could only be induced up to +1.89 +/- 0.74 D. Higher changes of up to +8.27 +/- 1.3 D could be achieved by means of repeated pulses per spot (20 pulses, 45 mJ, 10 Hz). Our experiments showed an obvious increase of dioptric changes when using a higher repetition rate while pulse energy and number were kept constant.(ABSTRACT TRUNCATED AT 250 WORDS)}, keywords = {Animals Cornea/pathology Corneal Transplantation/*instrumentation/pathology Laser Coagulation/*instrumentation Microscopy, Electron, Scanning Myopia/pathology/surgery Refraction, Ocular Sheep Swine}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7812097}, year = {1994}, type = {Journal Article} } |
A.
Reichle,
H.
Diddens,
F.
Altmayr,
J.
Rastetter, and
R.
Andreesen,
Chemomodulation of drugs involved in multiple resistance in chronic lymphatic leukemia of the B-cell type, Cancer Chemother Pharmacol. , vol. 34, no. 4, pp. 307-16, 1994.
Chemomodulation of drugs involved in multiple resistance in chronic lymphatic leukemia of the B-cell type, Cancer Chemother Pharmacol. , vol. 34, no. 4, pp. 307-16, 1994.
U.
Schmidt Erfurth,
H.
Diddens,
M.
Bamberg, and
T.
Hasan,
Carrier-Mediated Targeting in Photodynamic Therapy of Retinoblastoma Cells, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 2119-2119, 1994.
Carrier-Mediated Targeting in Photodynamic Therapy of Retinoblastoma Cells, Investigative Ophthalmology & Visual Science , vol. 35, no. 4, pp. 2119-2119, 1994.
1993
U.
SchmidtErfurth,
D.
Jacobs,
T. J.
Flotte,
E.
Gragoudas,
T.
Hasan, and
Reginald
Birngruber,
Photothrombosis of Ocular Neovascularization Using Benzoporphyrin Derivative (Bpd), Investigative Ophthalmology & Visual Science , vol. 34, no. 4, pp. 1303-1303, 1993.
Photothrombosis of Ocular Neovascularization Using Benzoporphyrin Derivative (Bpd), Investigative Ophthalmology & Visual Science , vol. 34, no. 4, pp. 1303-1303, 1993.
Reginald Birngruber,
Augenschäden durch Registrierkassen mit Laserscanner, Dtsch. med. Wschr. , vol. 118, pp. 51-52, 1993.
Augenschäden durch Registrierkassen mit Laserscanner, Dtsch. med. Wschr. , vol. 118, pp. 51-52, 1993.
J.
Roider,
N.
Michaud,
T.
Flotte, and
Reginald
Birngruber,
Histologie von Netzhautläsionen nach kontinuierlicher Bestrahlung und nach selektiver Mikrokoagulation des retinalen Pigmentepithels, Ophthalmologe , vol. 90, no. 3, pp. 274-8, 1993.
Histologie von Netzhautläsionen nach kontinuierlicher Bestrahlung und nach selektiver Mikrokoagulation des retinalen Pigmentepithels, Ophthalmologe , vol. 90, no. 3, pp. 274-8, 1993.
File: | query.fcgi |
Bibtex: | @article{Roider1993, author = {Roider, J. and Michaud, N. and Flotte, T. and Birngruber, R.}, title = {Histologie von Netzhautläsionen nach kontinuierlicher Bestrahlung und nach selektiver Mikrokoagulation des retinalen Pigmentepithels}, journal = {Ophthalmologe}, volume = {90}, number = {3}, pages = {274-8}, note = {0941-293X (Print) English Abstract Journal Article}, abstract = {Mild continuous wave (CW) irradiation (100 ms, 20 mW, 514 nm) and irradiation with 100 repetitive 5 microseconds laser pulses (3 or 6 microJ, 514 nm) at a repetition rate of 500 Hz was performed to the regio macularis of chinchilla rabbits. The angiographically visible lesions were histologically followed up to 4 weeks. With both irradiation modalities the original retinal pigment epithelium (RPE) was replaced by a monolayer of new RPE cells. Only minimal immediate and no subsequent damage to the photoreceptors was found after selective RPE photocoagulation. Only minimal inflammatory response was found after selective RPE photocoagulation in contrast to CW photocoagulation where macrophages, RPE cells and lymphocytes regularly appear in the damaged photoreceptor layer.}, keywords = {Animals Laser Coagulation/*instrumentation Light Coagulation/*instrumentation Microscopy, Electron, Scanning Microsurgery/*instrumentation Photoreceptors/injuries/pathology Pigment Epithelium of Eye/pathology/*surgery Rabbits Regeneration/physiology Retina/*injuries/pathology Wound Healing/physiology}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8334331}, year = {1993}, type = {Journal Article} } |
J.
Roider,
F.
Hillenkamp, and
T.
Flotte,
Microphotocoagulation: selective effects of repetitive short laser pulses, Proc Natl Acad Sci U S A , vol. 90, no. 18, pp. 8643-7, 1993.
Microphotocoagulation: selective effects of repetitive short laser pulses, Proc Natl Acad Sci U S A , vol. 90, no. 18, pp. 8643-7, 1993.
Y.
Pan,
C.W.
Du,
X.D.
Liu,
Z.G.
Li, and
Reginald
Birngruber,
Monte-carlo simulation of magneto-birefringence in magnetic fluids, J Appl Phys , vol. 73, no. 10, pp. 6142-6144, 1993.
Monte-carlo simulation of magneto-birefringence in magnetic fluids, J Appl Phys , vol. 73, no. 10, pp. 6142-6144, 1993.
A.
Obana,
M.
Matsumoto,
Tokuhiko
Miki,
K. G.
Eckert,
Reginald
Birngruber, and
V. P.
Gabel,
Quantification of indocyanine-green enhancement of diode laser photocoagulation, Nippon Ganka Gakkai Zasshi , vol. 97, no. 5, pp. 581-6, 1993.
Quantification of indocyanine-green enhancement of diode laser photocoagulation, Nippon Ganka Gakkai Zasshi , vol. 97, no. 5, pp. 581-6, 1993.
File: | query.fcgi |
Bibtex: | @article{Obana1993, author = {Obana, A. and Matsumoto, M. and Miki, T. and Eckert, K. G. and Birngruber, R. and Gabel, V. P.}, title = {[Quantification of indocyanine-green enhancement of diode laser photocoagulation]}, journal = {Nippon Ganka Gakkai Zasshi}, volume = {97}, number = {5}, pages = {581-6}, note = {0029-0203 (Print) English Abstract Journal Article}, abstract = {The enhancement by indocyanine-green (ICG) of diode laser photocoagulation was quantified. Since ICG concentration in blood increases and decreases rapidly after a single injection, it is difficult to quantify the exact enhancing effect of ICG. A steady-state plasma concentration (about 30 micrograms/ml) of ICG was achieved by injection of 2.5 mg/kg of ICG followed by continuous injection of 0.45 micrograms/kg/min of ICG. The threshold energy values to obtain grayish white retinal burn or choriocapillary occlusion were evaluated at this steady concentration of ICG, and compared with the values in the absence of ICG. The use of ICG decreased the energy values 7% for retinal burn and 8% for choriocapillary occlusion. Although the total dosage of ICG during the continuous injection was high, the enhancement of retinal burn and choriocapillary occlusion was small.}, keywords = {Animals Choroid/pathology/surgery Indocyanine Green/administration & dosage/pharmacokinetics/*pharmacology Infusions, Intravenous *Laser Coagulation Rabbits Retina/pathology/surgery}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8337962}, year = {1993}, type = {Journal Article} } |
Reginald
Birngruber,
Y.
Hefetz,
J.
Roider,
U.
Schmidt,
C. A.
Puliafito, and
Alfred
Vogel,
Spatial confinement of intraocular picoseconds-photodisruption effects, Ophthalmologe , vol. 90, no. 4, pp. 387-90, 1993.
Spatial confinement of intraocular picoseconds-photodisruption effects, Ophthalmologe , vol. 90, no. 4, pp. 387-90, 1993.
File: | query.fcgi |
Bibtex: | @article{Birngruber1993, author = {Birngruber, R. and Hefetz, Y. and Roider, J. and Schmidt, U. and Fujimoto, J. G. and Puliafito, C. A. and Vogel, Alfred}, title = {[Spatial confinement of intraocular picoseconds-photodisruption effects]}, journal = {Ophthalmologe}, volume = {90}, number = {4}, pages = {387-90}, note = {0941-293X (Print) English Abstract Journal Article}, abstract = {Laser photodisruption is a routinely performed clinical procedure in intraocular microsurgery of post-cataract membranes, anterior synechies and iridectomies. Damage ranges of several millimeters in diameter, however, limit the use of nanosecond photodisruption close to delicate structures, e.g., in the posterior vitreous. Multiple ps-laser pulses of about 100 microJ pulse energy were used to produce disruptive effects in the anterior lens capsule in rabbit eyes in vivo. Ophthalmoscopical and morphological investigations of these effects were compared with those of minimal ns-disruptions. The direct tissue separation effects as well as the collateral damage zones are about one order of magnitude smaller if ps-laser pulses are used. Minimal sizes of disruptive effects are about 50 microns to 150 microns and 500 microns to 1000 microns for ps- and ns-pulses, respectively. The substantial improvement of spatial confinement of ps-photodisruption enables increased precision of intraocular laser microsurgery and opens up new areas of clinical application in structures like the cornea, anterior chamber angle, and crystalline lens.}, keywords = {Animals Lasers/*adverse effects Lens Capsule, Crystalline/*injuries/pathology Light Coagulation/*instrumentation Microsurgery/instrumentation Rabbits}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8374239}, year = {1993}, type = {Journal Article} } |
A.
Obana,
B.
Lorenz, and
Reginald
Birngruber,
Transscleral and indirect ophthalmoscope diode laser retinal photocoagulation: experimental quantification of the therapeutic range for their application in the treatment of retinopathy of prematurity, Graefes Arch Clin Exp Ophthalmol , vol. 231, no. 7, pp. 378-83, 1993.
Transscleral and indirect ophthalmoscope diode laser retinal photocoagulation: experimental quantification of the therapeutic range for their application in the treatment of retinopathy of prematurity, Graefes Arch Clin Exp Ophthalmol , vol. 231, no. 7, pp. 378-83, 1993.
File: | query.fcgi |
Bibtex: | @article{Obana1993, author = {Obana, A. and Lorenz, B. and Birngruber, R.}, title = {Transscleral and indirect ophthalmoscope diode laser retinal photocoagulation: experimental quantification of the therapeutic range for their application in the treatment of retinopathy of prematurity}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {231}, number = {7}, pages = {378-83}, note = {0721-832X (Print) Comparative Study Journal Article}, abstract = {Laser indirect ophthalmoscope (LIO) photocoagulation and transscleral photocoagulation through the conjunctiva and subconjunctiva were performed in the fundus of chinchilla gray rabbits using various exposure times and powers, and the thresholds for retinal blanching and choroidal hemorrhage were determined. The therapeutic range was described for both applications as the ratio between energy values to produce grayish white lesions and hemorrhage at 50% probability. The therapeutic range appeared to remain almost constant with different exposure times. The mean ratio with LIO was 3.2 +/- 0.28, similar to that with slit-lamp delivery reported in our previous study. The mean ratio with transscleral photocoagulation through the conjunctiva and subconjunctiva were 2.48 +/- 0.28 and 2.38 +/- 0.26, respectively. The variability of LIO appeared to be a little lower than with transscleral photocoagulation. There was no significant difference between the variability with transscleral photocoagulation through the conjunctiva and subconjunctiva.}, keywords = {Animals Choroid Hemorrhage/etiology/pathology Fundus Oculi Humans Infant, Newborn Laser Coagulation/adverse effects/*methods Ophthalmoscopy Rabbits Retina/*surgery Retinal Diseases/etiology/pathology Retinopathy of Prematurity/*surgery Semiconductors}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8406062}, year = {1993}, type = {Journal Article} } |
A.
Obana,
B.
Lorenz, and
A.
Gässler,
The risk of choroidal hemorrhage with diode laser photocoagulation, Jpn J Ophthalmic Surg , vol. 6, no. 2, pp. 285-290, 1993.
The risk of choroidal hemorrhage with diode laser photocoagulation, Jpn J Ophthalmic Surg , vol. 6, no. 2, pp. 285-290, 1993.
Y.
Pan,
C.W.
Du,
X.D.
Liu,
Z.G.
Li, and
Reginald
Birngruber,
Wavelength dependence of the faraday effect and magneto-birefringence in ferrofluid thin films., J Appl Phys , vol. 73, no. 10, pp. 6139-6141, 1993.
Wavelength dependence of the faraday effect and magneto-birefringence in ferrofluid thin films., J Appl Phys , vol. 73, no. 10, pp. 6139-6141, 1993.
J.
Roider,
N.
Michaud,
T.
Flotte, and
Reginald
Birngruber,
Selective Rpe Photocoagulation by 1 Usec Laser-Pulses, Investigative Ophthalmology & Visual Science , vol. 34, no. 4, pp. 960-960, 1993.
Selective Rpe Photocoagulation by 1 Usec Laser-Pulses, Investigative Ophthalmology & Visual Science , vol. 34, no. 4, pp. 960-960, 1993.
J. H. C.
Inderfurth,
M. B.
Frish,
R. D.
Ferguson, and
Reginald
Birngruber,
Research Towards Development of a Dynamic Reflectometer for Control of Laser-Induced Retinal Photocoagulation, Investigative Ophthalmology & Visual Science , vol. 34, no. 4, pp. 960-960, 1993.
Research Towards Development of a Dynamic Reflectometer for Control of Laser-Induced Retinal Photocoagulation, Investigative Ophthalmology & Visual Science , vol. 34, no. 4, pp. 960-960, 1993.
H.
Chaudhry,
M.
Lynch,
K.
Schomacker,
K.
Gregory, and
I.
Kochevar,
Relaxation of vascular smooth muscle induced by low-power laser radiation, Photochem Photobiol , vol. 58, no. 5, pp. 661-9, 1993.
Relaxation of vascular smooth muscle induced by low-power laser radiation, Photochem Photobiol , vol. 58, no. 5, pp. 661-9, 1993.
1992
U.
Schmidt,
W.
Bauman,
K.
Schomacker,
E.
Gragoudas,
T.
Hasan, and
Reginald
Birngruber,
Photosensitizing Potency of Benzoporphyrin Derivative (Bpd) Associated with Human Low-Density-Lipoprotein (Ldl), Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 1253-1253, 1992.
Photosensitizing Potency of Benzoporphyrin Derivative (Bpd) Associated with Human Low-Density-Lipoprotein (Ldl), Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 1253-1253, 1992.
A.
Obana,
B.
Lorenz,
K. G.
Eckert,
V. P.
Gabel, and
Reginald
Birngruber,
Dye-Enhanced Diode-Laser Photocoagulation Using Continuous Injection of Indocyanine Green, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 721-721, 1992.
Dye-Enhanced Diode-Laser Photocoagulation Using Continuous Injection of Indocyanine Green, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 721-721, 1992.
C. P.
Lin,
C. A.
Puliafito,
James G.
Fujimoto, and
Reginald
Birngruber,
Effects of Single and Multiple Picosecond Laser-Pulses on Rpe Cells, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 721-721, 1992.
Effects of Single and Multiple Picosecond Laser-Pulses on Rpe Cells, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 721-721, 1992.
K.
Jungnickel, and
Alfred
Vogel,
Efficiency of bursts in intraocular Nd: YAG laser surgery, Lasers and Light in Ophthalmology , vol. 5, no. 2, pp. 95 - 99, 1992.
Efficiency of bursts in intraocular Nd: YAG laser surgery, Lasers and Light in Ophthalmology , vol. 5, no. 2, pp. 95 - 99, 1992.
Y. K.
Weaver,
C. P.
Lin,
S.
Schuman,
W. J.
Woods,
C. A.
Puliafito,
James G.
Fujimoto, and
Reginald
Birngruber,
Experimental Iridotomy with a Picosecond Neodymium-Ag Laser, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 1265-1265, 1992.
Experimental Iridotomy with a Picosecond Neodymium-Ag Laser, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 1265-1265, 1992.
W.
Wetzel, and
Reginald
Birngruber,
Laser Sclerostomy Abexterno Using the Erbium-Yag Laser and a New Application System, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 1018-1018, 1992.
Laser Sclerostomy Abexterno Using the Erbium-Yag Laser and a New Application System, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 1018-1018, 1992.
V.
Gekeler,
G.
Frese,
A.
Noller,
R.
Handgretinger,
A.
Wilisch,
H.
Schmidt,
C. P.
Muller,
R.
Dopfer,
T.
Klingebiel, and
H.
Diddens,
Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase pi gene expression in primary and relapsed state adult and childhood leukaemias, Br J Cancer , vol. 66, no. 3, pp. 507-17, 1992.
Mdr1/P-glycoprotein, topoisomerase, and glutathione-S-transferase pi gene expression in primary and relapsed state adult and childhood leukaemias, Br J Cancer , vol. 66, no. 3, pp. 507-17, 1992.
J.
Roider,
J.
Troccoli,
R. R.
Anderson,
T. J.
Flotte, and
Reginald
Birngruber,
Microvasculature Occlusion by Repetitive Short Laser-Pulses, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 722-722, 1992.
Microvasculature Occlusion by Repetitive Short Laser-Pulses, Investigative Ophthalmology & Visual Science , vol. 33, no. 4, pp. 722-722, 1992.
Q.
Ren,
V.
Venugopalan,
K.
Schomacker,
T. F.
Deutsch,
T. J.
Flotte,
C. A.
Puliafito, and
Reginald
Birngruber,
Mid-infrared laser ablation of the cornea: a comparative study, Lasers Surg Med , vol. 12, no. 3, pp. 274-81, 1992.
Mid-infrared laser ablation of the cornea: a comparative study, Lasers Surg Med , vol. 12, no. 3, pp. 274-81, 1992.
File: | query.fcgi |
Bibtex: | @article{Ren1992, author = {Ren, Q. and Venugopalan, V. and Schomacker, K. and Deutsch, T. F. and Flotte, T. J. and Puliafito, C. A. and Birngruber, R.}, title = {Mid-infrared laser ablation of the cornea: a comparative study}, journal = {Lasers Surg Med}, volume = {12}, number = {3}, pages = {274-81}, note = {0196-8092 (Print) Comparative Study Journal Article}, abstract = {The ablation thresholds and patterns of collateral damage in cornea produced by Er:YAG (2.94 microns) and Er:YSGG (2.79 microns) lasers were measured. Two different pulse durations, 200 microseconds (normal spiking mode) and 100 ns (Q-switched mode), were used at both wavelengths. In the normal spiking mode, damage zones of 16 +/- 2 microns and 39 +/- 7 microns and ablation thresholds of 250 +/- 20 mJ/cm2 and 420 +/- 35 mJ/cm2 were measured at 2.94 microns and 2.79 microns, respectively. In the Q-switched mode, damage zones of 4 +/- 2 microns and ablation thresholds of 150 +/- 10 mJ/cm2 were found irrespective of the laser used. The similarity between the results using the Er:YAG and Er:YSGG lasers in the Q-switched mode suggest that either laser can be used with equal effectiveness for corneal trephination.}, keywords = {Animals Cattle Cornea/pathology/*surgery *Light Coagulation/*methods}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1508021}, year = {1992}, type = {Journal Article} } |
V. P.
Gabel,
B.
Lorenz,
A.
Obana,
Alfred
Vogel, and
Reginald
Birngruber,
Problems of clinical application of diode lasers., Lasers Light Ophthalmol , vol. 4, no. 3/4, pp. 157-163, 1992.
Problems of clinical application of diode lasers., Lasers Light Ophthalmol , vol. 4, no. 3/4, pp. 157-163, 1992.
U.
Schmidt,
T.
Hasan, and
Reginald
Birngruber,
Selektiver Verschluss okularer Neovaskularisationen durch photodynamische Therapie (PDT), Ophthalmologe , vol. 89, no. 5, pp. 391-4, 1992.
Selektiver Verschluss okularer Neovaskularisationen durch photodynamische Therapie (PDT), Ophthalmologe , vol. 89, no. 5, pp. 391-4, 1992.
File: | query.fcgi |
Bibtex: | @article{Schmidt1992, author = {Schmidt, U. and Birngruber, R. and Hasan, T.}, title = {Selektiver Verschluss okularer Neovaskularisationen durch photodynamische Therapie (PDT)}, journal = {Ophthalmologe}, volume = {89}, number = {5}, pages = {391-4}, note = {0941-293X (Print) English Abstract Journal Article}, abstract = {Photodynamic therapy (PDT) has successfully been used to induce vascular occlusion via endothelial damage and subsequent thrombosis. To increase the selective of this method for neovascularizations, characteristics in the ultrastructure of the proliferative vessel wall allow physiological vessels to be spared and predominantly neovascularizations to be occluded: (a) Due to the disturbance of the blood-retina barrier, free dye molecules accumulate within the vascular wall. Using a dye with prolonged retention, such as phthalocyanine (CASPc), it is possible to thrombose neovascularizations 24 h post injection while leaving the physiological vasculature of the anterior segment of the rabbit eye unaffected. (b) Proliferating endothelial cells express high numbers of low-density lipoprotein (LDL) receptors. Chlorin e6 (Ce6), a potent photosensitizer, is covalently bound to LDL. Intravascularly, ce6-LDL complexes selectively label neovascular walls. Since ce6-LDL is incorporated intracellular into enzymatically active lysosomes, photothrombosis is effectively achieved at low drug and light doses in vivo. In addition, the induced damage is spatially confined to the inner vascular lining. We conclude that carrier-mediated PDT may offer a new and sensitive approach for selective treatment of intraocular neovascularizations.}, keywords = {Animals Blood-Retinal Barrier/drug effects/physiology Cell Division/drug effects/physiology Endothelium, Vascular/drug effects/pathology *Photochemotherapy Rabbits Retinal Neovascularization/*drug therapy/pathology}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1304219}, year = {1992}, type = {Journal Article} } |
Alfred Vogel,
Temperature profiles in human retina and choroid during laser coagulation with different wavelengths ranging from 514 to 810 nm., Lasers Light Ophthalmol , vol. 5, no. 1, pp. 9-16, 1992.
Temperature profiles in human retina and choroid during laser coagulation with different wavelengths ranging from 514 to 810 nm., Lasers Light Ophthalmol , vol. 5, no. 1, pp. 9-16, 1992.
U.
Schmidt-Erfurth, and
Alfred
Vogel,
The influence of wavelength on the laser power required for retinal photocoagulation in cataractous human eyes., Lasers Light Ophthalmol , vol. 5, no. 2, pp. 69-78, 1992.
The influence of wavelength on the laser power required for retinal photocoagulation in cataractous human eyes., Lasers Light Ophthalmol , vol. 5, no. 2, pp. 69-78, 1992.
A.
Obana,
B.
Lorenz,
A.
Gässler, and
Reginald
Birngruber,
The therapeutic range of chorioretinal photocoagulation with diode and argon lasers:an experimental comparison, Lasers Light Ophthalmol , vol. 4, no. 3/4, pp. 147-156, 1992.
The therapeutic range of chorioretinal photocoagulation with diode and argon lasers:an experimental comparison, Lasers Light Ophthalmol , vol. 4, no. 3/4, pp. 147-156, 1992.
K
Jungnickel,
S
Rein, and
A
Vogel,
Untersuchungen zur Plasmabildung bei der Nd: YAG-Laserchirurgie: Katarakt, Der Ophthalmologe , vol. 89, no. 4, pp. 283-287, 1992.
Untersuchungen zur Plasmabildung bei der Nd: YAG-Laserchirurgie: Katarakt, Der Ophthalmologe , vol. 89, no. 4, pp. 283-287, 1992.
J.
Roider,
N. A.
Michaud, and
T. J.
Flotte,
Response of the retinal pigment epithelium to selective photocoagulation, Arch Ophthalmol , vol. 110, no. 12, pp. 1786-92, 1992.
Response of the retinal pigment epithelium to selective photocoagulation, Arch Ophthalmol , vol. 110, no. 12, pp. 1786-92, 1992.
1991
Y. K.
Weaver,
C. P.
Lin,
C. A.
Puliafito,
James G.
Fujimoto, and
Reginald
Birngruber,
Intraocular Photoablation by a High Repetition Rate Picosecond Nd-Yag Laser, Investigative Ophthalmology & Visual Science , vol. 32, no. 4, pp. 1224-1224, 1991.
Intraocular Photoablation by a High Repetition Rate Picosecond Nd-Yag Laser, Investigative Ophthalmology & Visual Science , vol. 32, no. 4, pp. 1224-1224, 1991.
U.
Schmidt,
T.
Hasan,
K.
Schomacker,
T.
Flotte, and
Reginald
Birngruber,
Selective Vessel Occlusion by Photochemically-Induced Thrombogenesis, Investigative Ophthalmology & Visual Science , vol. 32, no. 4, pp. 1162-1162, 1991.
Selective Vessel Occlusion by Photochemically-Induced Thrombogenesis, Investigative Ophthalmology & Visual Science , vol. 32, no. 4, pp. 1162-1162, 1991.
R.
Macfarlane,
A.
Teramura,
C. J.
Owen,
S.
Chase,
R.
Torre,
K. W.
Gregory,
J. W.
Peterson,
J. A.
Parrish,
N. T.
Zervas, and
Reginald
Birngruber,
Treatment of vasospasm with a 480-nm pulsed-dye laser, J Neurosurg , vol. 75, no. 4, pp. 613-22, 1991.
Treatment of vasospasm with a 480-nm pulsed-dye laser, J Neurosurg , vol. 75, no. 4, pp. 613-22, 1991.
File: | query.fcgi |
Bibtex: | @article{Macfarlane1991, author = {Macfarlane, R. and Teramura, A. and Owen, C. J. and Chase, S. and de la Torre, R. and Gregory, K. W. and Peterson, J. W. and Birngruber, R. and Parrish, J. A. and Zervas, N. T.}, title = {Treatment of vasospasm with a 480-nm pulsed-dye laser}, journal = {J Neurosurg}, volume = {75}, number = {4}, pages = {613-22}, note = {0022-3085 (Print) Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.}, abstract = {Laser energy at a wavelength of 480 nm was applied in 1-microseconds pulses of 3 to 10 mJ to two models of vasospasm. Rabbit common carotid arteries (CCA's) were constricted chronically by the application of human blood within a silicone sheath. Peak vasospasm developed 24 to 48 hours later, and persisted for up to 6 days. Endovascular laser treatment was delivered to 40 CCA's via a 200-microns diameter silica quartz fiber introduced through the femoral artery. The CCA caliber increased from 60% of the pre-vasospasm control diameter to a minimum post-laser diameter of 83% of control. No instances of laser-induced perforation or of arterial thrombosis were observed for up to 60 days after treatment. Prophylactic laser application to nine normal vessels was able to attenuate the development of vasospasm if blood was applied immediately thereafter (88% vs. 59% of control diameter, p less than 0.02), but not if blood was applied 7 days later. Studies in 16 normal CCA's established that there was a considerable margin between the laser energy required to induce dilatation and that which caused perforation, providing that the fiber remained relatively central within the artery. Morphological examination demonstrated focal loss of endothelial cells immediately after laser application, followed approximately 7 days later by the development of areas of intimal hyperplasia. Only minimal changes were observed in the medial or adventitial layers. In a second study, the basilar artery of seven dogs was constricted chronically by two intracisternal injections of autologous blood 3 days apart. Five dogs received endovascular laser treatment 7 or 10 days after the first injection, when basilar artery diameter was reduced to a mean of 61% and 77% of control, respectively. Immediately following treatment, basilar artery diameter increased to 104% and 102% of resting diameter, respectively. Both untreated and laser-treated arteries were smaller than the control diameter at 30 days (80% and 82%, respectively), but in each group the vasodilatory response to hypercapnia was preserved. These findings indicate that 1-microsecond laser pulses are well tolerated by systemic and cerebral arteries in two different animal models, and suggest that the 480-nm pulsed-dye laser may have an application for the treatment or prophylaxis of cerebral vasospasm.}, keywords = {Animals Basilar Artery/surgery Carotid Arteries/surgery/ultrastructure Carotid Artery Diseases/pathology/*surgery Chronic Disease Constriction, Pathologic/surgery Dogs Ischemic Attack, Transient/pathology/*surgery *Laser Surgery Light Coagulation Rabbits Spasm/pathology/*surgery}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1885979}, year = {1991}, type = {Journal Article} } |
A.
Teramura,
R.
Macfarlane,
C. J.
Owen,
R.
Torre,
K. W.
Gregory,
J. A.
Parrish,
J. W.
Peterson,
N. T.
Zervas, and
Reginald
Birngruber,
Application of the 1-microsecond pulsed-dye laser to the treatment of experimental cerebral vasospasm, J Neurosurg , vol. 75, no. 2, pp. 271-6, 1991.
Application of the 1-microsecond pulsed-dye laser to the treatment of experimental cerebral vasospasm, J Neurosurg , vol. 75, no. 2, pp. 271-6, 1991.
File: | query.fcgi |
Bibtex: | @article{Teramura1991, author = {Teramura, A. and Macfarlane, R. and Owen, C. J. and de la Torre, R. and Gregory, K. W. and Birngruber, R. and Parrish, J. A. and Peterson, J. W. and Zervas, N. T.}, title = {Application of the 1-microsecond pulsed-dye laser to the treatment of experimental cerebral vasospasm}, journal = {J Neurosurg}, volume = {75}, number = {2}, pages = {271-6}, note = {0022-3085 (Print) In Vitro Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.}, abstract = {Laser energy of 480 nm was applied in 1-microsecond pulses varying between 2.2 and 10 mJ to in vitro and in vivo models of cerebral vasospasm. First, the pulsed-dye laser was applied intravascularly via a 320-microns fiber to basilar artery segments from six dogs. The segments were mounted in a vessel-perfusion apparatus and constricted to, on average, 70% of resting diameter by superfusion with dog hemolysate. Immediate increase in basilar artery diameter occurred to a mean of 83% of control. In a second model, the basilar artery was exposed transclivally in the rabbit. In three normal animals, superfusion of the artery with rabbit hemolysate resulted in a reduction of mean vessel diameter to 81% of control. Following extravascular application of the laser, vessels returned to an average of 106% of the resting state. In six rabbits, the basilar artery was constricted by two intracisternal injections of autologous blood. 3 days apart. Two to 4 days after the second injection, the basilar artery was exposed. Extravascular laser treatment from a quartz fiber placed perpendicular to the vessel adventitia resulted in an immediate 53% average increase in caliber to an estimated 107% of control. No reconstriction was observed over a period of up to 5 hours. Morphologically, damage to the arterial wall was slight. This preliminary investigation suggests that the 1-microsecond pulsed-dye laser may be of benefit in the treatment of cerebral vasospasm.}, keywords = {Animals Basilar Artery/surgery/ultrastructure Dogs Endothelium, Vascular/ultrastructure Female Ischemic Attack, Transient/pathology/*surgery *Laser Surgery Male Microscopy, Electron, Scanning Rabbits Vasodilation}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2072166}, year = {1991}, type = {Journal Article} } |
Y.
Hefetz,
J.
Roider,
C. A.
Puliafito,
T.
Flotte, and
Reginald
Birngruber,
Low Repetition Rate Picosecond Photodisruption in Ocular Structures, Investigative Ophthalmology & Visual Science , vol. 32, no. 4, pp. 798-798, 1991.
Low Repetition Rate Picosecond Photodisruption in Ocular Structures, Investigative Ophthalmology & Visual Science , vol. 32, no. 4, pp. 798-798, 1991.
J.
Roider,
N.
Michaud,
T.
Flotte, and
Reginald
Birngruber,
Microcoagulation of the fundus. Experimental results of repeated laser pulse exposure, Fortschr Ophthalmol , vol. 88, no. 5, pp. 473-6, 1991.
Microcoagulation of the fundus. Experimental results of repeated laser pulse exposure, Fortschr Ophthalmol , vol. 88, no. 5, pp. 473-6, 1991.
File: | query.fcgi |
Bibtex: | @article{Roider1991, author = {Roider, J. and Michaud, N. and Flotte, T. and Birngruber, R.}, title = {[Microcoagulation of the fundus. Experimental results of repeated laser pulse exposure]}, journal = {Fortschr Ophthalmol}, volume = {88}, number = {5}, pages = {473-6}, note = {0723-8045 (Print) English Abstract Journal Article}, abstract = {Angiographically visible lesions were produced in the fundus of rabbit eyes with repetitive 5 microseconds pulses and continuous wave exposures with 50-ms to 1-s pulse duration from an modified argon laser (514 nm). The ophthalmoscopic and the fluorescein angiographic findings showed less damage in the neural retina and the choroid after repetitively pulsed irradiation. Light microscopy and transmission electron microscopy showed that the neural retina and the choroid can mostly be spared by using repetitive 5 microseconds pulses, even though the damage to the retinal pigment epithelium is similar to the damage caused by continuous wave irradiation. Possible clinical applications, e.g. for macular edema and central serous retinopathy, are discussed.}, keywords = {Animals Fluorescein Angiography Light Coagulation/*adverse effects Microscopy, Electron Ophthalmoscopy Pigment Epithelium of Eye/*injuries/pathology Rabbits}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1757035}, year = {1991}, type = {Journal Article} } |
A.G.
Doukas,
A.D.
Zweig,
J.K.
Frisoli,
T. F.
Deutsch, and
Reginald
Birngruber,
Non-invasive determination of shock wave pressure generated by optical breakdown., Appl Phys B , vol. 53, pp. 237-245, 1991.
Non-invasive determination of shock wave pressure generated by optical breakdown., Appl Phys B , vol. 53, pp. 237-245, 1991.
Alfred
Vogel,
C.
Dlugos,
R.
Nuffer, and
Reginald
Birngruber,
Optical properties of human sclera, and their consequences for transscleral laser applications, Lasers Surg Med , vol. 11, no. 4, pp. 331-40, 1991.
Optical properties of human sclera, and their consequences for transscleral laser applications, Lasers Surg Med , vol. 11, no. 4, pp. 331-40, 1991.