Tom Pfeiffer

Doktorand




Gebäude MFC1, Raum 3

Email:
Phone:
Fax:

link to Huber-lab site

Publications

2020

  • Schmidt, Mark and Pfeiffer, Tom and Grill, Christin and Huber, Robert and Jirauschek, Christian: Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers. OSA Continuum, no. 3, pp. 1589-1607, Optical Society of America, 2020
    BibTeX Link 
    @article{schmidt2020self,
  title={Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers},
  author={Schmidt, Mark and Pfeiffer, Tom and Grill, Christin and Huber, Robert and Jirauschek, Christian},
  journal={OSA Continuum},
  volume={3},
  number={6},
  pages={1589--1607},
  year={2020},
keywords={AG-Huber_FDML},
url={https://doi.org/10.1364/OSAC.389972}, 
  publisher=  {Optical Society of America}
}
  • Cecchetti, L;Wang, T;Hoogendoorn, A;Witberg, K T;Ligthart, J M. R.;Daemen, J;van Beusekom, H M. M.;Pfeiffer, T;Huber, R A;Wentzel, J J;van der Steen, A F W and van Soest, G: In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT. The International Journal of Cardiovascular Imaging, 2020
    BibTeX Link 
    @article{cecchetti2020vitro,

   author = {Cecchetti, L;Wang, T;Hoogendoorn, A;Witberg, K T;Ligthart, J M. R.;Daemen, J;van Beusekom, H M. M.;Pfeiffer, T;Huber, R A;Wentzel, J J;van der Steen, A F W and van Soest, G},
   title = {In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT},
   journal = {The International Journal of Cardiovascular Imaging},
   ISSN = {1573-0743},
   
   url = {https://doi.org/10.1007/s10554-020-01796-7},
   year = {2020},
   type = {Journal Article}
}
 
keywords = {AG-Huber_OCT},
  • Tom Pfeiffer and Madita Göb and Wolfgang Draxinger and Sebastian Karpf and Jan Philip Kolb and Robert Huber: Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging. Biomed. Opt. Express, no. 11, pp. 6799-6811, OSA, Nov, 2020
    BibTeX Link 
    @article{Pfeiffer:20,
author = {Tom Pfeiffer and Madita G\"{o}b and Wolfgang Draxinger and Sebastian Karpf and Jan Philip Kolb and Robert Huber},
journal = {Biomed. Opt. Express},
keywords = {AG-Huber_OCT; High speed imaging; Image quality; Optical coherence tomography; Swept lasers; Swept sources; Systems design},
number = {11},
pages = {6799--6811},
publisher = {OSA},
title = {Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging},
volume = {11},
month = {Nov},
year = {2020},
doi = {10.1364/BOE.402477},
abstract = {In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze them point by point and describe the appropriate solutions. We prove that coherent averaging is possible at MHz OCT-speed without special interferometer designs or digital phase stabilization. We find, that in our system up to \&\#x223C;100x coherent averaging is possible while achieving a sensitivity increase close to the ideal values. This corresponds to a speed reduction from 3.3 MHz to 33 kHz and a sensitivity gain of 20 dB. We show an imaging comparison between coherent and magnitude averaging of a human finger knuckle joint in vivo with 121\&\#x00A0;dB sensitivity for the coherent case. Further, the benefits of computational downscaling in low sensitivity MHz-OCT systems are analyzed.},
}
  • Grill, C; Lotz, S; Blömker,T; Kastner, D; Pfeiffer,T; Karpf, S; Schmidt, M; Draxinger, W; Jirauschek, C and Huber, R: Beating of two FDML lasers in real time. in Fiber Lasers XVII: Technology and Systems, no. 11260, pp. 132 - 138, SPIE, 2020
    BibTeX Link Datei 
    @inproceedings{Grill2020,
author = {Grill, C; Lotz, S; Blömker,T; Kastner, D; Pfeiffer,T; Karpf, S; Schmidt, M; Draxinger, W;  Jirauschek, C and Huber, R},
title = {{Beating of two FDML lasers in real time}},
volume = {11260},
booktitle = {Fiber Lasers XVII: Technology and Systems},
editor = {Liang Dong},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {132 -- 138},
keywords = {AG-Huber_FDML, FDML laser, fiber lasers, beat signal, OCT, Optical Coherence Tomography, Fourier domain mode locking},
year = {2020},
doi = {10.1117/12.2545794},

}

2019

  • Julian Klee, Jan Philip Kolb, Christin Grill, Wolfgang Draxinger ,Tom Pfeiffer, Robert Huber: Zero roll-off retinal MHz-OCT using an FDML-laser. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780S, no. 11078, 2019
    BibTeX Link Datei 
    @proceeding{Klee2019,
author = {Julian Klee, Jan Philip Kolb, Christin Grill, Wolfgang Draxinger ,Tom Pfeiffer, Robert Huber},
title = {Zero roll-off retinal MHz-OCT using an FDML-laser},
volume = {11078},
year = {2019},

URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527034/Zero-roll-off-retinal-MHz-OCT-using-an-FDML-laser/10.1117/12.2527034.short},
keywords = {AG-Huber_OCT},
booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780S},
eprint = {}
}
  • Madita Göb,Tom Pfeiffer,Robert Huber: Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780Y, no. 11078, 2019
    BibTeX Link Datei 
    @proceeding{Goeb2019,
author = {Madita Göb,Tom Pfeiffer,Robert Huber},
title = {Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy},
volume = {11078},
year = {2019},

URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/110780Y/Towards-combined-optical-coherence-tomography-and-multi-spectral-imaging-with/10.1117/12.2526796.short},
keywords = {AG-Huber_OCT},
booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780Y},
eprint = {}
}
  • Schmidt, Mark;Pfeiffer, Tom;Grill, Christin;Huber, Robert and Jirauschek, Christian: Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers. in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference, pp. 1-1, 2019
    BibTeX Link Poster 
    @Schmidt2019,
   author = {Schmidt, Mark;Pfeiffer, Tom;Grill, Christin;Huber, Robert and Jirauschek, Christian},
   title = {Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers},
   pages = {1-1},
   DOI = {10.1109/CLEOE-EQEC.2019.8873213},
   year = {2019},
   type = {Book},
booktitle = { 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference}
}
  • Miura, Y; Draxinger, W; Grill, C; Pfeiffer, T; Grisanti, S and Huber, R: MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780E, no. 11078, 2019
    BibTeX Link Datei 
    @proceeding{Miura2019,
author = { Miura, Y; Draxinger, W; Grill, C; Pfeiffer, T; Grisanti, S and Huber, R},
title = { MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye},
volume = {11078},
year = {2019},

URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527123/MHz-OCT-for-low-latency-virtual-reality-guided-surgery/10.1117/12.2527123.short},
keywords = {AG-Huber_OCT},
booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780E},
eprint = {}
}
  • Kastner, D; Blömker, T; Pfeiffer, T; Grill, C; Schmidt, M; Jirauschek, C and Huber, R: Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser. 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, in 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, pp. cj_7_5, Optical Society of America, 2019
    BibTeX Link Datei 
    @inproceedings{Kastner:19,
author = {Kastner, D; Bl\"{o}mker, T; Pfeiffer, T; Grill, C; Schmidt, M; Jirauschek, C and Huber, R},
booktitle = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference},
journal = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference},
keywords = {Fourier domain mode locking; Image quality; Optical coherence tomography; Phase noise; Ring lasers; Tunable lasers},
pages = {cj_7_5},
publisher = {Optical Society of America},
title = {Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser},
year = {2019},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
doi = { 10.1109/CLEOE-EQEC.2019.8872860},
abstract = {Fourier Domain Mode Locking (FDML) lasers are light sources that generate a sequence of narrowband optical frequency sweeps at the fundamental or harmonic of the cavity repetition rate \[1\]. This frequency swept output can also be considered as a sequence of strongly chirped, long pulses. FDML lasers are mainly used in swept source optical coherence tomography (SS-OCT), a medical imaging technique. The coherence length of the source, i.e. the intra-sweep phase stability of an FDML sweep, is decisive for the image quality and performance of OCT imaging \[2\].},
}
  • Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R: Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates. J pone 14(3), pp. e0213144, 2019
    BibTeX Link 
    @article{Kolb2019,
   author = {Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R},
   title = {Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates},
   journal = {J pone} {14(3)},
 keywords = {AG-Huber_OCT},
   url = {https://doi.org/10.1371/journal.pone.0213144},
   pages = {e0213144},
   ISSN = {1932-6203},
   
   year = {2019},
   type = {Journal Article}
}
  • Schmidt, M; Pfeiffer, T; Grill, C; Huber, R and Jirauschek, C: Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers. in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC), pp. 1-1, 2019
    BibTeX Link Datei 
    @inproceedings{schmidt2019coexistence,
  title={Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers},
  author={Schmidt, M; Pfeiffer, T; Grill, C; Huber, R and Jirauschek, C},
  booktitle={2019 Conference on Lasers and Electro-Optics Europe \& European Quantum Electronics Conference (CLEO/Europe-EQEC)},
  pages={1--1},
  year={2019},
  organization={IEEE},
keywords= { AG-Huber_FDML},
url={  https://ieeexplore.ieee.org/document/8872381}

}
  • Draxinger, D; Miura, Y; Grill, C; Pfeiffer, T and Huber, R: A real-time video-rate 4D MHz-OCT microscope with high definition and low latency virtual reality display. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 1107802, no. 11078, 2019
    BibTeX Link Datei 
    @proceeding{Draxinger2019,
author = {Draxinger, D; Miura, Y; Grill, C; Pfeiffer, T and Huber, R},
title = {A real-time video-rate 4D MHz-OCT microscope with high definition and low latency virtual reality display},
volume = {11078},
year = {2019},
url={  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527177/A-real-time-video-rate-4D-MHz-OCT-microscope-with/10.1117/12.2527177.short}

keywords = {AG-Huber_OCT},
booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 1107802},
eprint = {}
}

2018

  • Eibl ,M; Weng, D; Hakert, H; Kolb, J P; Pfeiffer, T; Hundt, J E; Huber, R and Karpf, S: Wavelength agile multi-photon microscopy with a fiber amplified diode laser. Biomedical Optics Express 9(12), pp. 6273-6282, 2018
    BibTeX Link 
    @article{Eibl2018,
author = { Eibl ,M; Weng, D; Hakert, H; Kolb, J P; Pfeiffer, T; Hundt, J E; Huber, R and Karpf, S},
title = {Wavelength agile multi-photon microscopy with a fiber amplified diode laser},
journal = {Biomedical Optics Express} {9(12)},
keywords = {AG-Huber_NL},
year = {2018},
pages = {6273--6282},
doi = {10.1364/BOE.9.006273},
}
  • Pfeiffer, T; Petermann, M; Draxinger, W; Jirauschek, C and Huber, R: Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography. Biomed Opt Expr 9(9), pp. 4130-4148, 2018
    BibTeX Link 
    @article{Pfeiffer2018,
   author = {Pfeiffer, T; Petermann, M; Draxinger, W; Jirauschek, C and Huber, R},
   title = {Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography},
   journal = {Biomed Opt Expr} {9(9)},
  
   pages = {4130-4148},
 DOI = {10.1364/BOE.9.004130},  

   year = {2018},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
   type = {Journal Article}
}
  • Schmidt, M. and Pfeiffer, T. and Grill, C. and Huber, R. and Jirauschek, C.: Self-Stabilization Mechanism in Fourier Domain Mode-Locked (FDML) Lasers. in EPS-QEOD Europhoton Conference Solid State, Fibre, and Waveguide Coherent Light Sources, European Physical Society EPS, 2018
    BibTeX Link 
    @inproceedings{Schmidt2018,
	author = {Schmidt, M. and  Pfeiffer, T. and  Grill, C. and  Huber, R. and  Jirauschek, C.}, 
	title = {Self-Stabilization Mechanism in Fourier Domain Mode-Locked (FDML) Lasers},
	booktitle = {EPS-QEOD Europhoton Conference Solid State, Fibre, and Waveguide Coherent Light Sources},
	publisher = {European Physical Society EPS},
	year = {2018},
keywords = {AG-Huber_FDML},
	language = {en},
	url = {http://www.europhoton.org/},
}
  • Schulz-Hildebrandt, H; Pfeiffer, T; Eixmann, T; Lohmann, S; Ahrens, M; Rehra, J; Draxinger, W; König, P; Huber, R and Gereon Hüttmann: High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography. Op Lett 43(18), pp. 4386-4389, 2018
    BibTeX Link 
    @article{Schulz-Hildebrandt2018b,
title = {High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography},
author = { Schulz-Hildebrandt, H; Pfeiffer, T; Eixmann, T; Lohmann, S; Ahrens, M; Rehra, J; Draxinger, W; K\"{o}nig, P; Huber, R and Gereon H\"{u}ttmann},
url = {https://doi.org/10.1364/OL.43.004386},


year = {2018},
date = {2018-09-05},
journal = {Op Lett} {43(18)},

pages = {4386-4389},
abstract = {We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 μm was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in spirals for scanning the sample, the beam quality remains constant over the entire field of view with a diameter of 0.8 mm. The scanning frequency was adjusted to 1.22 kHz for use with a 3.28 MHz Fourier domain mode locked OCT system. Densely sampled volumes have been imaged at a rate of 6 volumes per second.

© 2018 Optical Society of America},
keywords = {Endoskope, AG-Huber_OCT},
pubstate = {published},
tppubtype = {article}
}
  • Kolb, J P; Pfeiffer, T; Eibl, M; Hakert, H and Huber, R: High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates. Biomed Opt Expr 9(1), pp. 120-130, 2018
    BibTeX Link 
    @article{Kolb2018,
   author = {Kolb, J P; Pfeiffer, T; Eibl, M; Hakert, H and Huber, R},
   title = {High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates},
   journal = {Biomed Opt Expr} {9(1)},
   
   pages = {120-130},
   DOI = {10.1364/BOE.9.000120},
   year = {2018},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
   type = {Journal Article}
}

2017

  • Wang, T; Pfeiffer, T; Wu, M; Wieser, W; Amenta, G; Draxinger, W; van der Steen, A F W; Huber, Robert and Soest, G van: Thermo-elastic optical coherence tomography. Opt Lett 42(17), pp. 3466-3469, 2017
    BibTeX Link 
    @article{Wang2017,
   author = {Wang, T; Pfeiffer, T; Wu, M; Wieser, W; Amenta, G; Draxinger, W; van der Steen, A F W; Huber, Robert and Soest, G van},
   title = {Thermo-elastic optical coherence tomography},
   journal = {Opt Lett} {42(17)},
  
   pages = {3466-3469},
   DOI = {10.1364/OL.42.003466},
   year = {2017},
keywords = {AG-Huber_OCT},
   type = {Journal Article}
}
  • Eibl, M; Karpf, S; Hakert, H; Weng, D; Pfeiffer, T; Kolb, J P and Huber, R: Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup. in Proc. SPIE 10414, pp. 1041403-1041403-7, 2017
    BibTeX Link 
    @inproceedings{Eibl2017,
   author = {Eibl, M; Karpf, S; Hakert, H; Weng, D; Pfeiffer, T; Kolb, J P and Huber, R},
   title = {Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup},
  booktitle = {Proc. SPIE} {10414},
  
  year = {2017},
keywords = {AG-Huber_NL},
   pages = {1041403-1041403-7},
   url = {http://dx.doi.org/10.1117/12.2286035},
   type = {Conference Proceedings}
}
  • Matthias Eibl and Sebastian Karpf and Daniel Weng and Hubertus Hakert and Tom Pfeiffer and Jan Philip Kolb and Robert Huber: Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate. Biomedical Optics Express, no. 8, pp. 3132-3142, OSA, Jul, 2017
    BibTeX Link 
    @article{HU_2017_Eibla_BOE,
author = {Matthias Eibl and Sebastian Karpf and Daniel Weng and Hubertus Hakert and Tom Pfeiffer and Jan Philip Kolb and Robert Huber},
journal = {Biomedical Optics Express},
number = {7},
pages = {3132--3142},
publisher = {OSA},
title = {Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate},
volume = {8},
month = {Jul},
year = {2017},
keywords = {AG-Huber_NL},
doi = {10.1364/BOE.8.003132}
}
  • Wang, Tianshi and Pfeiffer, Tom and Wu, Min and Wieser, Wolfgang and Draxinger, Wolfgang and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs: Short pulse laser induced thermo-elastic deformation imaging. in Proc. SPIE, no. 10062, pp. 100620C-100620C-4, 2017
    BibTeX Link 
    @inproceedings{Wang2017,
   author = {Wang, Tianshi and Pfeiffer, Tom and Wu, Min and Wieser, Wolfgang and Draxinger, Wolfgang and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs},
   title = {Short pulse laser induced thermo-elastic deformation imaging},
booktitle = Proc. SPIE},
  volume = {10062},
  year = {2017},
   pages = {100620C-100620C-4},
  url = {http://dx.doi.org/10.1117/12.2251502},
keywords = {AG-Huber_OCT},
   type = {Conference Proceedings}
}
  • Pfeiffer, T; Draxinger, W; Grill, C and Huber, R: Long-range live 3D-OCT at different spectral zoom levels. in Proc. SPIE 10416, pp. 104160L1-4, 2017
    BibTeX Link 
    @inproceedings{Pfeiffer2017,
   author = {Pfeiffer, T; Draxinger, W; Grill, C and Huber, R},
   title = {Long-range live 3D-OCT at different spectral zoom levels},
   booktitle = {Proc. SPIE} {10416},
  url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10416/1/Long-range-live-3D-OCT-at-different-spectral-zoom-levels/10.1117/12.2287484.short?SSO=1},
   pages = {104160L1-4},
   year = {2017},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
   type = {Conference Proceedings}
}
  • Laves, Max-Heinrich and Schoob, Andreas and Kahrs, Lüder A. and Pfeiffer, Tom and Huber, Robert and Ortmaier, Tobias: Feature tracking for automated volume of interest stabilization on 4D-OCT images. in Proc. SPIE, no. 10135, pp. 101350W-101350W-7, 2017
    BibTeX Link 
    @inproceedings{Laves2017,
   author = {Laves, Max-Heinrich and Schoob, Andreas and Kahrs, Lüder A. and Pfeiffer, Tom and Huber, Robert and Ortmaier, Tobias},
   title = {Feature tracking for automated volume of interest stabilization on 4D-OCT images},
 booktitle = {Proc. SPIE},
   volume = {10135},
   pages = {101350W-101350W-7},
  year = {2017},
   url = {http://dx.doi.org/10.1117/12.2255090},
keywords = {AG-Huber_OCT},
   type = {Conference Proceedings}
}
  • Pfeiffer, Tom and Draxinger, Wolfgang and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Huber, Robert: Analysis of FDML lasers with meter range coherence. in Proc. SPIE, no. 10053, pp. 100531T-100531T-6, 2017
    BibTeX Link 
    @inproceedings{Pfeiffer2017,
   author = {Pfeiffer, Tom and Draxinger, Wolfgang and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Huber, Robert},
   title = {Analysis of FDML lasers with meter range coherence},
   booktitle = {Proc. SPIE},
   volume = {10053},
   pages = {100531T-100531T-6},
    url = {http://dx.doi.org/10.1117/12.2254792},

  year = {2017},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
   type = {Conference Proceedings}
}
  • Kolb, J P; Klee, J; Pfeiffer, Tand Huber, R: 1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full eye length and retinal ultra-widefield OCT. in Proc. SPIE 10416, pp. 104160J-104160J-6, 2017
    BibTeX Link 
    @inproceedings{Kolb2017,
   author = {Kolb, J P; Klee, J; Pfeiffer, Tand Huber, R},
   title = {1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full     eye length and retinal ultra-widefield OCT},
  booktitle = {Proc. SPIE} {10416},

  pages = {104160J-104160J-6},
  year = {2017},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
   url = {http://dx.doi.org/10.1117/12.2286854},
   type = {Conference Proceedings}
}

2016

  • Kolb, Jan Philip and Klein, Thomas and Eibl, Matthias and Pfeiffer, Tom and Wieser, Wolfgang and Huber, Robert: Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm. in Proc. SPIE, no. 9697, pp. 969703-969703-8, 2016
    BibTeX Link 
    @inproceedings{Kolb2016,
   author = {Kolb, Jan Philip and Klein, Thomas and Eibl, Matthias and Pfeiffer, Tom and Wieser, Wolfgang and Huber, Robert},
   title = {Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm},
   booktitle = {Proc. SPIE},
   volume = {9697},

   pages = {969703-969703-8},
   year= { 2016}
   note = {10.1117/12.2214758},
   abstract = {We present a new design of a Fourier Domain Mode Locked laser (FDML laser), which provides a new record in sweep range at ~1μm center wavelength: At the fundamental sweep rate of 2x417 kHz we reach 143nm bandwidth and 120nm with 4x buffering at 1.67MHz sweep rate. The latter configuration of our system is characterized: The FWHM of the point spread function (PSF) of a mirror is 5.6μm (in tissue). Human in vivo retinal imaging is performed with the MHz laser showing more details in vascular structures. Here we could measure an axial resolution of 6.0μm by determining the FWHM of specular reflex in the image. Additionally, challenges related to such a high sweep bandwidth such as water absorption are investigated.},
   url = {http://dx.doi.org/10.1117/12.2214758},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
   type = {Conference Proceedings}
}
  • Wang, Tianshi and Pfeiffer, Tom and Regar, Evelyn and Wieser, Wolfgang and van Beusekom, Heleen and Lancee, Charles T. and Springeling, Geert and Krabbendam-Peters, Ilona and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs: Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy. JACC: Cardiovascular Imaging, no. 9, pp. 622-623, 2016
    BibTeX Link 
    @article{Wang2016,
   author = {Wang, Tianshi and Pfeiffer, Tom and Regar, Evelyn and Wieser, Wolfgang and van Beusekom, Heleen and Lancee, Charles T. and Springeling, Geert and Krabbendam-Peters, Ilona and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs},
   title = {Heartbeat OCT and Motion-Free 3D In Vivo Coronary Artery Microscopy},
   journal = {JACC: Cardiovascular Imaging},
   volume = {9},
   number = {5},
   pages = {622-623},
   note = {10.1016/j.jcmg.2015.08.010},
   abstract = {Intravascular optical coherence tomography (IV-OCT) has gained widespread use over the past few years, offering highly detailed images of coronary artery pathologies and interventions (1). In contrast to the cross-sectional view, longitudinal sections and 3-dimensional (3D) renderings are affected by cardiac motion artifacts and undersampling, complicating interpretation and measurements (2). We developed Heartbeat OCT, a new OCT method that achieves up to 4,000 frames/s imaging speed for isotropically sampled volume datasets acquired within the diastolic phase of 1 cardiac cycle to restore 3D IV-OCT image fidelity. In this research letter, we present the first in vivo data acquired with this new experimental technology.},
   keywords = {AG-Huber_OCT},
   ISSN = {1936-878X},
   DOI = {10.1016/j.jcmg.2015.08.010},
   year = {2016},
   type = {Journal Article}
}

2015

  • Wang, Tianshi and Pfeiffer, Tom and Regar, Evelyn and Wieser, Wolfgang and van Beusekom, Heleen and Lancee, Charles T. and Springeling, Geert and Krabbendam, Ilona and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs: Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography. Biomedical Optics Express, no. 6, pp. 5021-5032, 2015
    BibTeX Link 
    @article{HU_2015_Wang,
   author = {Wang, Tianshi and Pfeiffer, Tom and Regar, Evelyn and Wieser, Wolfgang and van Beusekom, Heleen and Lancee, Charles T. and Springeling, Geert and Krabbendam, Ilona and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs},
   title = {Heartbeat OCT: in vivo intravascular megahertz-optical coherence tomography},
   journal = {Biomedical Optics Express},
   volume = {6},
   number = {12},
   pages = {5021-5032},
   abstract = {Cardiac motion artifacts, non-uniform rotational distortion and undersampling affect the image quality and the diagnostic impact of intravascular optical coherence tomography (IV-OCT). In this study we demonstrate how these limitations of IV-OCT can be addressed by using an imaging system that we called “Heartbeat OCT”, combining a fast Fourier Domain Mode Locked laser, fast pullback, and a micromotor actuated catheter, designed to examine a coronary vessel in less than one cardiac cycle. We acquired in vivo data sets of two coronary arteries in a porcine heart with both Heartbeat OCT, working at 2.88 MHz A-line rate, 4000 frames/s and 100 mm/s pullback speed, and with a commercial system. The in vivo results show that Heartbeat OCT provides faithfully rendered, motion-artifact free, fully sampled vessel wall architecture, unlike the conventional IV-OCT data. We present the Heartbeat OCT system in full technical detail and discuss the steps needed for clinical translation of the technology.},
  keywords = {AG-Huber_OCT},
   DOI = {10.1364/BOE.6.005021},
   year = {2015},
   type = {Journal Article}
}
  • Pfeiffer, Tom and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Kolb, Jan-Phillip and Eibl, Matthias and Huber, Robert: Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging. Proc. SPIE, no. 9697, pp. 96970S-96970S-5, 2015
    BibTeX Link 
    @inproceedings{Pfeiffer2016,
   author = {Pfeiffer, Tom and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Kolb, Jan-Phillip and Eibl, Matthias and Huber, Robert},
   title = {Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging},
Year={  2015}
   journal = {Proc. SPIE},
   volume = {9697},
   pages = {96970S-96970S-5},
   note = {10.1117/12.2214788},
   abstract = {In order to realize fast OCT-systems with adjustable line rate, we investigate averaging of image data from an FDML based MHz-OCT-system. The line rate can be reduced in software and traded in for increased system sensitivity and image quality. We compare coherent and incoherent averaging to effectively scale down the system speed of a 3.2 MHz FDML OCT system to around 100 kHz in postprocessing. We demonstrate that coherent averaging is possible with MHz systems without special interferometer designs or digital phase stabilisation. We show OCT images of a human finger knuckle joint in vivo with very high quality and deep penetration.},
   url = {http://dx.doi.org/10.1117/12.2214788},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
   type = {Conference Proceedings}
}

2014

  • Zhang, Yaokun and Pfeiffer, Tom and Weller, Marcel and Wieser, Wolfgang and Huber, Robert and Raczkowsky, Jörg and Schipper, Jörg and Wörn, Heinz and Klenzner, Thomas: Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale. BioMed research international, no. 2014, pp. 251814-24, n,, 2014
    BibTeX Link Link 
    @Article{HU_2014_Zhang_a,
  Title                    = {{Optical coherence tomography guided laser cochleostomy: towards the accuracy on tens of micrometer scale}},
  Author                   = {Zhang, Yaokun and Pfeiffer, Tom and Weller, Marcel and Wieser, Wolfgang and Huber, Robert and Raczkowsky, J\"{o}rg and Schipper, J\"{o}rg and W\"{o}rn, Heinz and Klenzner, Thomas},
  Journal                  = {BioMed research international},
  Year                     = {2014},
  Month                    = jan,
  Pages                    = {251814--24},
  Volume                   = {2014},
  Doi                      = {10.1155/2014/251814},
  ISSN                     = {2314-6141},
keywords = {AG-Huber_OCT},
  Url                      = {http://www.hindawi.com/journals/bmri/2014/251814/}
}
  • Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert: High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s. Biomedical optics express, no. 5, pp. 2963-77, p,, 2014
    BibTeX Link Link 
    @Article{HU_2014_Wieser_a,
  Title                    = {{High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s}},
  Author                   = {Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert},
  Journal                  = {Biomedical optics express},
  Year                     = {2014},

  Month                    = sep,
  Number                   = {9},
  Pages                    = {2963--77},
  Volume                   = {5},

  Doi                      = {10.1364/BOE.5.002963},
  ISSN                     = {2156-7085},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
  Url                      = {http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-5-9-2963}
}
  • Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert: A 4-D OCT Engine with 1 GVoxel/s. Optics and Photonics News, no. 25, pp. 36, OSA, c,, 2014
    BibTeX Link 
    @Article{HU_2014_Wieser_b,
  Title                    = {{A 4-D OCT Engine with 1 GVoxel/s}},
  Author                   = {Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert},
  Journal                  = {Optics and Photonics News},
  Year                     = {2014},

  Month                    = dec,
  Number                   = {12},
  Pages                    = {36 },
  Volume                   = {25},
keywords = {AG-Huber_FDML, AG-Huber_OCT},

  Publisher                = {OSA},
  Url                      = { http://www.osa-opn.org/home/articles/volume_25/december_2014/extras/a_4-d_oct_engine_with_1_gvoxel_s/#.VcH21Pl5raw}
}

2013

  • Wang, Tianshi and Wieser, Wolfgang and Springeling, Geert and Beurskens, Robert and Lancee, Charles T and Pfeiffer, Tom and van der Steen, Antonius F W and Huber, Robert and van Soest, Gijs: Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second. in European Conferences on Biomedical Optics, pp. 88020O 1-2, International Society for Optics and Photonics, n,, 2013
    BibTeX Link Link 
    @InProceedings{HU_2013_Wang_b,
  Title                    = {{Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second}},
  Author                   = {Wang, Tianshi and Wieser, Wolfgang and Springeling, Geert and Beurskens, Robert and Lancee, Charles T and Pfeiffer, Tom and van der Steen, Antonius F W and Huber, Robert and van Soest, Gijs},
  Booktitle                = {European Conferences on Biomedical Optics},
  Year                     = {2013},
  Editor                   = {Bouma, Brett E and Leitgeb, Rainer A},
  Month                    = jun,
  Pages                    = {88020O 1--2 },
  Publisher                = {International Society for Optics and Photonics},

  Doi                      = {10.1117/12.2032723},
keywords = {AG-Huber_OCT},
  Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2032723}
}
  • Klein, Thomas and Andre, Raphael and Wieser, Wolfgang and Pfeiffer, Tom and Huber, Robert: Joint aperture detection for speckle reduction and increased collection efficiency in ophthalmic MHz OCT. Biomedical optics express, no. 4, pp. 619-34, r,, 2013
    BibTeX Link Link 
    @Article{HU_2013_Klein_b,
  Title                    = {{Joint aperture detection for speckle reduction and increased collection efficiency in ophthalmic MHz OCT}},
  Author                   = {Klein, Thomas and Andre, Raphael and Wieser, Wolfgang and Pfeiffer, Tom and Huber, Robert},
  Journal                  = {Biomedical optics express},
  Year                     = {2013},

  Month                    = apr,
  Number                   = {4},
  Pages                    = {619--34},
  Volume                   = {4},

  Doi                      = {10.1364/BOE.4.000619},
  ISSN                     = {2156-7085},
keywords = {AG-Huber_OCT},
  Url                      = {http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-4-4-619}
}
  • Wang, Tianshi and Wieser, Wolfgang and Springeling, Geert and Beurskens, Robert and Lancee, Charles T and Pfeiffer, Tom and van der Steen, Antonius F W and Huber, Robert and van Soest, Gijs: Intravascular optical coherence tomography imaging at 3200 frames per second. Optics letters, no. 38, pp. 1715-7, y,, 2013
    BibTeX Link Link 
    @Article{HU_2013_Wang_a,
  Title                    = {{Intravascular optical coherence tomography imaging at 3200 frames per second}},
  Author                   = {Wang, Tianshi and Wieser, Wolfgang and Springeling, Geert and Beurskens, Robert and Lancee, Charles T and Pfeiffer, Tom and van der Steen, Antonius F W and Huber, Robert and van Soest, Gijs},
  Journal                  = {Optics letters},
  Year                     = {2013},

  Month                    = may,
  Number                   = {10},
  Pages                    = {1715--7},
  Volume                   = {38},

  Doi                      = {10.1364/OL.38.001715},
  ISSN                     = {1539-4794},
keywords = {AG-Huber_OCT},
  Url                      = {http://www.opticsinfobase.org/ol/abstract.cfm?uri=ol-38-10-1715}
}
  • Zhang, Yaokun and Pfeiffer, Tom and Wieser, Wolfgang and Weller, Marcel and Huber, Robert and Klenzner, Thomas and Raczkowsky, Jörg and Wörn, Heinz: History compounding: a novel speckle reduction technique for OCT guided cochleostomy. in SPIE BiOS, pp. 85713H.1-3, International Society for Optics and Photonics, r,, 2013
    BibTeX Link Link 
    @InProceedings{HU_2013_Zhang_a,
  Title                    = {{History compounding: a novel speckle reduction technique for OCT guided cochleostomy}},
  Author                   = {Zhang, Yaokun and Pfeiffer, Tom and Wieser, Wolfgang and Weller, Marcel and Huber, Robert and Klenzner, Thomas and Raczkowsky, J\"{o}rg and W\"{o}rn, Heinz},
  Booktitle                = {SPIE BiOS},
  Year                     = {2013},
  Editor                   = {Fujimoto, James G and Izatt, Joseph A and Tuchin, Valery V},
  Month                    = mar,
  Pages                    = {85713H.1--3},
  Publisher                = {International Society for Optics and Photonics},

  Doi                      = {10.1117/12.2006979},
keywords = {AG-Huber_OCT},
  Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.2006979}
}

2012

  • Klein, Thomas and Wieser, Wolfgang and Andre, Raphael and Pfeiffer, Tom and Eigenwillig, Christoph M and Huber, Robert: Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second. in SPIE BiOS, pp. 82131E 1-3, International Society for Optics and Photonics, b,, 2012
    BibTeX Link Link 
    @InProceedings{HU_2012_Klein_b,
  Title                    = {{Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second}},
  Author                   = {Klein, Thomas and Wieser, Wolfgang and Andre, Raphael and Pfeiffer, Tom and Eigenwillig, Christoph M and Huber, Robert},
  Booktitle                = {SPIE BiOS},
  Year                     = {2012},
  Editor                   = {Izatt, Joseph A and Fujimoto, James G and Tuchin, Valery V},
  Month                    = feb,
  Pages                    = {82131E 1--3 },
  Publisher                = {International Society for Optics and Photonics},

  Doi                      = {10.1117/12.908798},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
  Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?doi=10.1117/12.908798}
}
  • Wieser, Wolfgang and Palte, Gesa and Eigenwillig, Christoph M and Biedermann, Benjamin R and Pfeiffer, Tom and Huber, Robert: Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools. Optics express, no. 20, pp. 9819-32, r,, 2012
    BibTeX Link Link 
    @Article{HU_2012_Wieser_a,
  Title                    = {{Chromatic polarization effects of swept waveforms in FDML lasers and fiber spools}},
  Author                   = {Wieser, Wolfgang and Palte, Gesa and Eigenwillig, Christoph M and Biedermann, Benjamin R and Pfeiffer, Tom and Huber, Robert},
  Journal                  = {Optics express},
  Year                     = {2012},

  Month                    = apr,
  Number                   = {9},
  Pages                    = {9819--32},
  Volume                   = {20},

  Doi                      = {10.1364/OE.20.009819},
  ISSN                     = {1094-4087},
keywords = {AG-Huber_FDML, AG-Huber_OCT},
  Url                      = {http://www.opticsinfobase.org/oe/abstract.cfm?uri=oe-20-9-9819\&id=231991}
}