1996
U.
SchmidtErfurth,
J.
Miller,
M.
Sickerberg,
A.
Strong,
U.
Hoehne,
M.
Fsachi,
Reginald
Birngruber,
H.
vandenBerg,
H.
Laqua,
E.
Gragoudas,
L.
Zografos, and
N.
Bressler,
Photodynamic therapy of subfoveal choroidal neovascularization using benzoporphyrin derivative: First results of a multi-center trial, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 580-580, 1996.
Photodynamic therapy of subfoveal choroidal neovascularization using benzoporphyrin derivative: First results of a multi-center trial, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 580-580, 1996.
R
Schmidt Erfurth,
Reginald
Birngruber, and
T
Hasan,
Photodynamic therapy in ocular vascular disease, Ieee Journal of Selected Topics in Quantum Electronics , pp. 988-996, 1996.
Photodynamic therapy in ocular vascular disease, Ieee Journal of Selected Topics in Quantum Electronics , pp. 988-996, 1996.
DOI: | Doi 10.1109/2944.577328 |
File: | WOS:A1996XD61600025 |
Bibtex: | ![]() @article{Schmidt-Erfurth1996, author = {Schmidt Erfurth, U; Birngruber, R and Hasan, T}, title = {Photodynamic therapy in ocular vascular disease}, journal = {Ieee Journal of Selected Topics in Quantum Electronics}, pages = {988-996}, note = {Xd616 Times Cited:5 Cited References Count:57}, abstract = {Photodynamic therapy (PDT) is a novel therapeutical approach which is noninvasive and potentially selective for neoplastic pathologies, Association of photosensitizers with low density lipoprotein (LDL) leads to direct targeting of the treated lesions with enhanced efficiency and selectivity. LDL-mediated PDT is particularly useful in the treatment of neovascular structures since LDL receptors are abundantly expressed on vascular endothelial cells, To evaluate the potential of selective photodynamic vasoocclusion in ocular neovascular disease a sequence of experiments was designed: Efficiency of the LDL-carrier was tested in vitro, the system was then transfered to an in vivo model demonstrating a vascularized neoplasm, Occlusion was successfully performed in experimentally induced neovascularization in the cornea, while selective photothrombosis of subretinal vasculature revealed lack of collateral damage, The experimental results were used to establish a first clinical trial for the use of PDT in age-related macular degeneration, one of the leading causes for blindness.}, keywords = {low-density-lipoprotein receptor activity plasma-lipoproteins singlet oxygen cells-invitro murine tumor hematoporphyrin invivo benzoporphyrin retinoblastoma}, ISSN = {1077-260X}, DOI = {Doi 10.1109/2944.577328}, url = {<Go to ISI>://WOS:A1996XD61600025}, year = {1996}, type = {Journal Article} } |
Reginald
Birngruber,
L.
Indorf,
D.
Soultanopoulos,
G.
Dröge,
H.
Eggers, and
U.
SchmidtErfurth,
Photodynamic occlusion of ocular neovascularization: Preclinical evaluation of liposomal zinc phthalocyanine, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 4214-4214, 1996.
Photodynamic occlusion of ocular neovascularization: Preclinical evaluation of liposomal zinc phthalocyanine, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 4214-4214, 1996.
Y.
Pan,
E.
Lankenau,
J.
Welzel,
Reginald
Birngruber, and
R.
Engelhardt,
Optical Coherence - Gated imaging of Biological Tissues, IEEE J Quant Electr , vol. 2, no. 4, pp. 1029-1034, 1996.
Optical Coherence - Gated imaging of Biological Tissues, IEEE J Quant Electr , vol. 2, no. 4, pp. 1029-1034, 1996.
W.
Wetzel,
U.
SchmidtErfurth,
D.
Spiegel,
P.
Jacobi,
M.
Buhl, and
Reginald
Birngruber,
Laser sclerostomy ab externo using a new Er:YAG laser device. A clinical multicenter study - Laser sclerostomy study group, Vision Research , vol. 36, pp. 2414-2414, 1996.
Laser sclerostomy ab externo using a new Er:YAG laser device. A clinical multicenter study - Laser sclerostomy study group, Vision Research , vol. 36, pp. 2414-2414, 1996.
Gerd
Gerling,
Alfred
Vogel,
E.
ElHifnawi,
N.
Koop,
G.
Dröge,
Reginald
Birngruber, and
Ralf
Brinkmann,
Morphological and biomorphometrical observations on laser thermal keratoplasty - Histological and biomorphometrical examination of the relationship between refractive change and the volume of laser thermal keratoplasty lesions following Cr:Tm:Ho:YAG laser treatment, German Journal of Ophthalmology , vol. 5, no. 2, pp. 84-91, 1996.
Morphological and biomorphometrical observations on laser thermal keratoplasty - Histological and biomorphometrical examination of the relationship between refractive change and the volume of laser thermal keratoplasty lesions following Cr:Tm:Ho:YAG laser treatment, German Journal of Ophthalmology , vol. 5, no. 2, pp. 84-91, 1996.
Ralf
Brinkmann,
N.
Koop,
K.
Kamm,
G.
Geerling,
J.
Kampmeier, and
Reginald
Birngruber,
Laser thermokeratoplasty: an in vitro and in vivo-study by means of a Continous Wave Mid-IR laser diode., Lasermedizin , vol. 12, pp. 179-186, 1996.
Laser thermokeratoplasty: an in vitro and in vivo-study by means of a Continous Wave Mid-IR laser diode., Lasermedizin , vol. 12, pp. 179-186, 1996.
Ralf
Brinkmann,
Norbert
Koop,
K.
Kamm,
Gerd
Geerling,
Juergen
Kampmeier, and
Reginald
Birngruber,
Laser Thermokeratoplasty: an in vitro and in vivo study by means of a cw mid-IR laser diode, Laser Medizin , vol. 12, pp. 179-186, 1996.
Laser Thermokeratoplasty: an in vitro and in vivo study by means of a cw mid-IR laser diode, Laser Medizin , vol. 12, pp. 179-186, 1996.
File: | 978-3-642-60306-8_83 |
Bibtex: | ![]() @article{Brinkmann1996-2, author = {Brinkmann, R;Koop, N;Kamm, K;Geerling, G;Kampmeier, J and Birngruber, R}, title = {Laser Thermokeratoplasty: an in vitro and in vivo study by means of a cw mid-IR laser diode}, journal = {Laser Medizin}, volume = {12}, Keywords = {Brechkraftänderung, Denaturierung, Hyperopie-Korrektur, Koagulation, Kollagen-Kontraaktion, Kornea, Temperaturberechnung}, pages = {179-186}, year = { 1996}, url = { https://doi.org/10.1007/978-3-642-60306-8_83}, type = {Journal Article} } |
J.
Kampmeier,
Ralf
Brinkmann, and
Reginald
Birngruber,
Laser thermokeratoplasty (LTK): Biomechanical properties and IR-laser induced forces in porcine cornea., Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 301-301, 1996.
Laser thermokeratoplasty (LTK): Biomechanical properties and IR-laser induced forces in porcine cornea., Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 301-301, 1996.
G.
Geerling,
Ralf
Brinkmann,
N.
Koop,
I.
Klingemann,
H.
Laqua, and
Reginald
Birngruber,
Laser thermokeratoplasty - Experimental study in minipigs with a cw-IR laser diode, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 304-304, 1996.
Laser thermokeratoplasty - Experimental study in minipigs with a cw-IR laser diode, Investigative Ophthalmology & Visual Science , vol. 37, no. 3, pp. 304-304, 1996.
M.
Zwaan,
U.
Behnle,
R.
Engelhardt,
Alfred
Vogel,
W.
Kloess,
Reginald
Birngruber, and
H. D.
Weiss,
In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium., Fortschr Röntgenstr , vol. 164, no. 1, pp. 68-71, 1996.
In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium., Fortschr Röntgenstr , vol. 164, no. 1, pp. 68-71, 1996.
Ralf
Brinkmann,
N.
Koop,
M. N.
AsiyoVogel,
B.
Kaftan,
Reginald
Birngruber, and
R.
Engelhardt,
CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy, Investigative Ophthalmology & Visual Science , vol. 37(3), pp. 305-305, 1996.
CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy, Investigative Ophthalmology & Visual Science , vol. 37(3), pp. 305-305, 1996.
Ralf
Brinkmann,
Juergen
Kampmeier,
Ulf
Grotehusmann,
Alfred
Vogel,
Norbert
Koop,
Mary
Asiyo-Vogel, and
Reginald
Birngruber,
Corneal collagen denaturation in laser thermokeratoplasty, 1996. pp. 56-63.
Corneal collagen denaturation in laser thermokeratoplasty, 1996. pp. 56-63.
File: | 12.239611 |
Bibtex: | ![]() @inproceedings{Brinkmann1996-7, author = {Brinkmann, Ralf and Kampmeier, Juergen and Grotehusmann, Ulf and Vogel, Alfred and Koop, Norbert and Asiyo-Vogel, Mary and Birngruber, Reginald}, title = {Corneal collagen denaturation in laser thermokeratoplasty}, volume = {2681}, pages = {56-63}, note = {10.1117/12.239611}, abstract = {In laserthermokeratoplasty (LTK) thermal denaturation and shrinkage of corneal collagen is used to correct hyperopia and astigmatism. In order to optimize dosimetry, the temperature at which maximal shrinkage of collagen fibrils occurs is of major interest. Since the exposure time in clinical LTK-treatment is limited to a few seconds, the kinetics of collagen denaturation as a rate process has to be considered, thus the time of exposure is of critical importance for threshold and shrinkage temperatures. We investigated the time-temperature correlation for corneal collagen denaturation within different time domains by turbidimetry of scattered HeNe laser probe light using a temperature controlled water bath and pulsed IR laser irradiation. In the temperature range of 60 degree(s)C to 95 degree(s)C we found an exponential relation between the denaturation time and temperature. For the typical LTK-treatment time of 2 s, a temperature of 95 degree(s)C is needed to induce thermal damage. Use of pulsed Holmium laser radiation gave significant scattering of HeNe laser probe light at calculated temperatures of around 100 degree(s)DC. Rate parameters according to the formalism of Arrhenius were fitted to these results. Force measurements showed the simultaneous onset of light scattering and collagen shrinkage.}, url = {http://dx.doi.org/10.1117/12.239611}, type = {Conference Proceedings}, Year ={ 1996} } |
U.
SchmidtErfurth,
T. J.
Flotte,
E. S.
Gragoudas,
K.
Schomacker,
Reginald
Birngruber, and
T.
Hasan,
Benzoporphyrin-lipoprotein-mediated photodestruction of intraocular tumors, Experimental Eye Research , vol. 62, no. 1, pp. 1-10, 1996.
Benzoporphyrin-lipoprotein-mediated photodestruction of intraocular tumors, Experimental Eye Research , vol. 62, no. 1, pp. 1-10, 1996.
DOI: | DOI 10.1006/exer.1996.0001 |
File: | WOS:A1996TT61200001 |
Bibtex: | ![]() @article{Schmidt-Erfurth1996, author = {SchmidtErfurth, U. and Flotte, T. J. and Gragoudas, E. S. and Schomacker, K. and Birngruber, R. and Hasan, T.}, title = {Benzoporphyrin-lipoprotein-mediated photodestruction of intraocular tumors}, journal = {Experimental Eye Research}, volume = {62}, number = {1}, pages = {1-10}, note = {Tt612 Times Cited:22 Cited References Count:43}, abstract = {Benzoporphyrin derivative (BPD), a sensitizer currently in clinical trials, was evaluated for the treatment of experimental Greene melanoma implanted in the rabbit iris. To improve tumor targeting, BPD was complexed with low-density lipoprotein (LDL) representing an endogenous carrier system for BPD as previously described. Twelve tumors were irradiated at a sensitizer dose of 2 mg kg(-1) body weight using a dye laser at 692 nm. Tumor responses were documented by photography, angiography and light and electron microscopy. All tumors treated with 80 J cm(-2) regressed irreversibly. The principal mechanism of tumor necrosis was thrombosis following disruption of endothelial membranes. Ultrastructure data suggested tumor cell damage, although evidence for this being the result of direct PDT-mediated tumor cell death was less clear. These data suggest that BPD-LDL may be used to improve the selectivity of photodynamic tumor therapy possibly by the increased uptake of lipoprotein-delivered sensitizer to neovascular endothelial cells. (C) 1996 Academic Press Limited}, keywords = {photodynamic therapy benzoporphyrin derivative low-density lipoprotein intraocular tumors, in vivo photodynamic therapy plasma-lipoproteins malignant-melanoma cholesterol-metabolism endothelial-cells hematoporphyrin photosensitization photoimmunotherapy biodistribution invitro}, ISSN = {0014-4835}, DOI = {DOI 10.1006/exer.1996.0001}, url = {<Go to ISI>://WOS:A1996TT61200001}, year = {1996}, type = {Journal Article} } |
Ralf
Brinkmann,
C.
Hansen,
D.
Mohrenstecher,
M.
Scheu, and
Reginald
Birngruber,
Analysis of cavitation dynamics during pulsed laser tissue ablation by optical on-line monitoring, Ieee Journal of Selected Topics in Quantum Electronics , vol. 2(4), pp. 826-835, 1996.
Analysis of cavitation dynamics during pulsed laser tissue ablation by optical on-line monitoring, Ieee Journal of Selected Topics in Quantum Electronics , vol. 2(4), pp. 826-835, 1996.
DOI: | Doi 10.1109/2944.577305 |
File: | WOS:A1996XD61600006 |
Bibtex: | ![]() @article{Brinkmann1996-1, author = {Brinkmann, R. and Hansen, C. and Mohrenstecher, D. and Scheu, M. and Birngruber, R.}, title = {Analysis of cavitation dynamics during pulsed laser tissue ablation by optical on-line monitoring}, journal = {Ieee Journal of Selected Topics in Quantum Electronics}, volume = {2(4)}, pages = {826-835}, note = {Xd616 Times Cited:20 Cited References Count:24}, abstract = {Flashlamp pumped mid-IR laser systems emitting in the 23-mu m wavelength range are widely used for various medical applications, especially for tissue ablation, Explosive evaporation is inevitably associated with this process due to the short pulse durations of these laser systems and the high absorption of tissue and water in this spectral regime, Tissue displacement and dissection occur in liquid environment as a consequence of the induced cavitation, Depending on the application these processes might enhance the tissue ablation but can also cause adverse tissue effects, The ablation dynamics were investigated by evaluating the change in rejected probe-light intensity reemitted from the application fiber tip. The ablated cavity and the signal was correlated to fast-flash photographs of the event. Based on this reflection signal a water/tissue discrimination system is introduced which can widely support medical laser applications. In laser sclerostomy ab externo, for example, this approach can be used as a feedback system to automatically control the ablation process. With such a system, adverse effects to adjacent tissue in the anterior chamber of the eye can be minimized.}, ISSN = {1077-260X}, DOI = {Doi 10.1109/2944.577305}, url = {<Go to ISI>://WOS:A1996XD61600006}, year = { 1996}, type = {Journal Article} } |
1995
J.
Inderfurth,
R. D.
Ferguson,
C. A.
Puliafito,
M. B.
Frish, and
Reginald
Birngruber,
Reflection measurement during retinal laser coagulation in patients. Development of an automatically controlled dosimeter, Ophthalmologe , vol. 92, no. 5, pp. 717-22, 1995.
Reflection measurement during retinal laser coagulation in patients. Development of an automatically controlled dosimeter, Ophthalmologe , vol. 92, no. 5, pp. 717-22, 1995.
File: | query.fcgi |
Bibtex: | ![]() @article{Inderfurth1995, author = {Inderfurth, J. and Ferguson, R. D. and Puliafito, C. A. and Frish, M. B. and Birngruber, R.}, title = {[Reflection measurement during retinal laser coagulation in patients. Development of an automatically controlled dosimeter]}, journal = {Ophthalmologe}, volume = {92}, number = {5}, pages = {717-22}, note = {0941-293X (Print) English Abstract Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.}, abstract = {PURPOSE: Retinal laser coagulation has limited reproducibility, because every laser exposition is unpredictably affected by pigmentation and media opacities. This can lead to complications. A feedback-controlled dosimeter would make retinal laser treatment a safer, more reproducible and faster procedure. METHOD: A reflectometer was developed that allows monitoring of the reflection of laser light during standard photocoagulation. Hundreds of coagulations in rabbit eyes and about 12,000 coagulations in patients undergoing routine laser treatment were recorded. RESULTS: The results of the first reflectance measurements in humans are presented along with extensive animal studies. A typical reflectance history was found for different lesion intensities. The degree of retinal whitening correlates with reflectance characteristics. These characteristics allow an early prediction of lesion intensity. Motion during laser exposure affects each coagulation in a fashion similar to spot size and exposure time. CONCLUSION: Reflectometry is the currently most effective means of monitoring lesion development. An automatic dosimeter for retinal photocoagulation seems feasible.}, keywords = {Animals Equipment Design Feasibility Studies Humans Laser Coagulation/*instrumentation Rabbits Radiotherapy Planning, Computer-Assisted/*instrumentation Retinal Diseases/*surgery Treatment Outcome}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8751004}, year = {1995}, type = {Journal Article} } |
W
Schmidterfurth,
G
Dröge,
W.
Wetzel, and
Reginald
Birngruber,
Mitomycin-C in Laser Sclerostomy - Time of Administration and Postoperative Hypotony, Invest Ophthal & VisScie , pp. S89-S89, 1995.
Mitomycin-C in Laser Sclerostomy - Time of Administration and Postoperative Hypotony, Invest Ophthal & VisScie , pp. S89-S89, 1995.
Y.
Pan,
Reginald
Birngruber,
J.
Rosperich, and
R.
Engelhardt,
Low-coherence optical tomography in turbid tissue: theoretical analysis., Appl Optics , vol. 34, no. 28, pp. 6564-6574, 1995.
Low-coherence optical tomography in turbid tissue: theoretical analysis., Appl Optics , vol. 34, no. 28, pp. 6564-6574, 1995.
W.
Wetzel,
U.
Schmidt-Erfurth,
G.
Haring,
J.
Roider,
G.
Dröge, and
Reginald
Birngruber,
Laser sclerostomy ab externo using two different infrared lasers: a clinical comparison, Ger J Ophthalmol , vol. 4, no. 1, pp. 1-6, 1995.
Laser sclerostomy ab externo using two different infrared lasers: a clinical comparison, Ger J Ophthalmol , vol. 4, no. 1, pp. 1-6, 1995.
File: | query.fcgi |
Bibtex: | ![]() @article{Wetzel1995, author = {Wetzel, W. and Schmidt-Erfurth, U. and Haring, G. and Roider, J. and Droge, G. and Birngruber, R.}, title = {Laser sclerostomy ab externo using two different infrared lasers: a clinical comparison}, journal = {Ger J Ophthalmol}, volume = {4}, number = {1}, pages = {1-6}, note = {0941-2921 (Print) Comparative Study Journal Article}, abstract = {This study was designed to compare the clinical results of an ab externo approach to laser sclerostomy using two different laser sources under identical conditions. A pulsed (200 microseconds) erbium-YAG laser (lambda = 2940 nm) and a pulsed (200 microseconds) holmium:YAG laser (lambda = 2120 nm) were used. The energy of each laser was transmitted via a fiber (300 microns in diameter) and applied near the limbus, with the fiber tip remaining in steady contact with the sclera. According to the higher tissue absorption coefficient, a shorter penetration depth and, therefore, fewer complications were expected for the Er:YAG laser. A total of 26 patients with advanced open-angle glaucoma were treated and followed for up to 6 months. In all cases a functioning fistula with a prominent filtering bleb and a marked reduction in the intraocular pressure (from up to 35 mm Hg to < 10 mm Hg) could be achieved primarily. The total energy required was about 4 times lower for erbium:YAG laser was compared with holmium:YAG laser sclerostomies. No complication occurred intraoperatively. Postoperatively, reversible adherence of the iris to the internal ostium was more frequently observed in Ho:YAG laser sclerostomies (60%) and small hyphemas were more often seen in Er:YAG laser sclerostomies (30%). After 6 months of follow-up, about 40% of the fistula remained patent in both groups. In principle, both lasers are suited to serve as energy sources for the described approach. Under the conditions of the present study, different levels of thermal effects did not cause any significant difference in the clinical success rate.(ABSTRACT TRUNCATED AT 250 WORDS)}, keywords = {Adult Chronic Disease Follow-Up Studies Glaucoma, Open-Angle/*surgery Humans Intraocular Pressure Laser Surgery/*methods Middle Aged Ostomy Postoperative Complications Prognosis Sclera/surgery *Sclerostomy}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7728103}, year = {1995}, type = {Journal Article} } |
U.
SchmidtErfurth,
T.
Hasan,
K.
Schomacker,
T.
Flotte, and
Reginald
Birngruber,
In-Vivo Uptake of Liposomal Benzoporphyrin Derivative and Photothrombosis in Experimental Corneal Neovascularization, Lasers in Surgery and Medicine , vol. 17, no. 2, pp. 178-188, 1995.
In-Vivo Uptake of Liposomal Benzoporphyrin Derivative and Photothrombosis in Experimental Corneal Neovascularization, Lasers in Surgery and Medicine , vol. 17, no. 2, pp. 178-188, 1995.
DOI: | DOI 10.1002/lsm.1900170207 |
File: | WOS:A1995RW60700006 |
Bibtex: | ![]() @article{Schmidt-Erfurth1995, author = {Schmidterfurth, U. and Hasan, T. and Schomacker, K. and Flotte, T. and Birngruber, R.}, title = {In-Vivo Uptake of Liposomal Benzoporphyrin Derivative and Photothrombosis in Experimental Corneal Neovascularization}, journal = {Lasers in Surgery and Medicine}, volume = {17}, number = {2}, pages = {178-188}, note = {Rw607 Times Cited:72 Cited References Count:39}, abstract = {Background and Objective: Photodynamic therapy (PDT) has been used successfully to occlude neovascularizations experimentally. We evaluated the vasoocclusive potential of benzoporphyrin derivative (BPD), a new photosensitizer currently in clinical trials. Since liposomally formulated BPD strongly binds to endogenous low density lipoproteins (LDL) after i.v. injection, LDL act as carrier to deliver BPD preferentially 60 proliferating endothelial cells. Study Design/Materials and Methods: Corneal neovascularizations in rabbits were used as model. Time-dependent uptake and retention of liposomal BPD were measured in vivo by monitoring the laser-induced fluorescence (LIF). Photothrombosis was induced using a dye laser emitting at 692 nm. Results: A maximal BPD concentration was measured at 60-90 minutes postinjection determining the optimal time interval for treatment. Exposures as low as 10 J/cm(2) allowed complete and irreversible neovascular occlusion as documented angiographically. Histology revealed selective endothelial damage, adjacent corneal stroma, or iris vessels, remained intact. Identical results were obtained using BPD directly complexed with LDL suggesting use of a LDL-mediated pathway. Conclusion: We suggest BPD-PDT for a selective treatment of neovascular diseases. (C) 1995 Wiley-Liss, Inc.}, keywords = {benzoporphyrin derivative ocular photothrombosis liposomes cornea neovascularization low-density lipoprotein photodynamic therapy laser photocoagulation photochemical initiation vascular occlusion lipid keratopathy endothelial-cells feeder vessels thrombosis hematoporphyrin}, ISSN = {0196-8092}, DOI = {DOI 10.1002/lsm.1900170207}, url = {<Go to ISI>://WOS:A1995RW60700006}, year = {1995}, type = {Journal Article} } |
G.
Schirner,
N.
Koop,
E.
ElHifnawi,
Reginald
Birngruber, and
Ralf
Brinkmann,
Experiments with Pulsed and Continuous-Wave Laser Sources to Optimize Laserthermo-Keratoplasty, Vision Research , vol. 35, pp. P167-P167, 1995.
Experiments with Pulsed and Continuous-Wave Laser Sources to Optimize Laserthermo-Keratoplasty, Vision Research , vol. 35, pp. P167-P167, 1995.
R.
Goldau,
H.
Twilfer,
M.
Zwaan,
M.
Morrin,
U.
Marquardt, and
Reginald
Birngruber,
In-vivo fluorescence spectroscopy of abdominal and iliac arterial in humans., Lasermedizin , vol. 11, pp. 212-218, 1995.
In-vivo fluorescence spectroscopy of abdominal and iliac arterial in humans., Lasermedizin , vol. 11, pp. 212-218, 1995.
G.
Schirner,
Ralf
Brinkmann,
G.
Dröge,
N.
Koop,
E. S.
Elhifnawi, and
Reginald
Birngruber,
Experimental Studies to Optimize Laser-Thermokeratoplasty Using Pulsed and Cw-Laser-Sources, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S716-S716, 1995.
Experimental Studies to Optimize Laser-Thermokeratoplasty Using Pulsed and Cw-Laser-Sources, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S716-S716, 1995.
W.
Wetzel,
R.
Otto,
W.
Falkenstein,
U.
Schmidt-Erfurth, and
Reginald
Birngruber,
Development of a new Er: YAG laser conception for laser sclerostomy ab externo: experimental and first clinical results, Ger J Ophthalmol , vol. 4, no. 5, pp. 283-8, 1995.
Development of a new Er: YAG laser conception for laser sclerostomy ab externo: experimental and first clinical results, Ger J Ophthalmol , vol. 4, no. 5, pp. 283-8, 1995.
File: | query.fcgi |
Bibtex: | ![]() @article{Wetzel1995, author = {Wetzel, W. and Otto, R. and Falkenstein, W. and Schmidt-Erfurth, U. and Birngruber, R.}, title = {Development of a new Er: YAG laser conception for laser sclerostomy ab externo: experimental and first clinical results}, journal = {Ger J Ophthalmol}, volume = {4}, number = {5}, pages = {283-8}, note = {0941-2921 (Print) Journal Article}, abstract = {The erbium:YAG laser is a preferable energy source for laser sclerostomy ab externo due to the high absorption of its radiation (2940-nm wavelength) in the aqueous parts of scleral tissue. It has thus far been a disadvantage that laser energy has to be transmitted from the laser source to the application site via very susceptible special optical fibers (ZrF). As a consequence of technical improvements, the laser source could be integrated into the application probe. Therefore, only a robust quartz fiber was necessary for contact application. A fiber diameter of 400 microns was chosen according to the experience gained in previous studies. A total of 24 eyes with chronical open-angle glaucoma were treated. A fistula end-point detection unit was developed for safe indication of a full-thickness perforation of the sclera. With a fiber diameter of 400 microns, a postoperative success rate of about 54% was achieved at 6 months follow-up. The automated full-thickness perforation detection prevented the application of additional, surplus laser pulses in the anterior chamber. The postoperative success rate could be improved over that achieved in previous studies. The new device/conception offers more technical reliability and is a further step toward minimally invasive fistulating laser surgery of open-angle glaucoma.}, keywords = {Erbium Follow-Up Studies Glaucoma, Open-Angle/*surgery Humans Laser Surgery/instrumentation/*methods Sclera/*surgery Treatment Outcome}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7496339}, year = {1995}, type = {Journal Article} } |
C. A.
Toth,
Reginald
Birngruber,
James G.
Fujimoto,
S. A.
Boppart,
M. R.
Hee,
C. D.
DiCarlo,
C. P.
Cain, and
W. P.
Roach,
Correlation between Optical Coherence Tomography, Clinical Examination and Histopathology of Macular Laser Lesions, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S207-S207, 1995.
Correlation between Optical Coherence Tomography, Clinical Examination and Histopathology of Macular Laser Lesions, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S207-S207, 1995.
J.
Roider,
U.
SchmidtErfurth,
H.
Hoerauf,
T.
Lasser,
Reginald
Birngruber, and
H.
Laqua,
Contact Diode-Laser Cyclophotocoagulation (Cpc) with a New Focusing Fiber Tip, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S559-S559, 1995.
Contact Diode-Laser Cyclophotocoagulation (Cpc) with a New Focusing Fiber Tip, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S559-S559, 1995.
F.
Schroer,
D.
Mohrenstecher,
G.
Dröge,
Ralf
Brinkmann, and
Reginald
Birngruber,
Ablation Dynamics in Laser Sclerostomy Ab-Externo, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S558-S558, 1995.
Ablation Dynamics in Laser Sclerostomy Ab-Externo, Investigative Ophthalmology & Visual Science , vol. 36, no. 4, pp. S558-S558, 1995.
1994
U.
Schmidt-Erfurth,
T.
Hasan,
E.
Gragoudas,
N.
Michaud,
T. J.
Flotte, and
Reginald
Birngruber,
Vascular targeting in photodynamic occlusion of subretinal vessels, Ophthalmology , vol. 101, no. 12, pp. 1953-61, 1994.
Vascular targeting in photodynamic occlusion of subretinal vessels, Ophthalmology , vol. 101, no. 12, pp. 1953-61, 1994.
File: | query.fcgi |
Bibtex: | ![]() @article{Schmidt-Erfurth1994, author = {Schmidt-Erfurth, U. and Hasan, T. and Gragoudas, E. and Michaud, N. and Flotte, T. J. and Birngruber, R.}, title = {Vascular targeting in photodynamic occlusion of subretinal vessels}, journal = {Ophthalmology}, volume = {101}, number = {12}, pages = {1953-61}, note = {0161-6420 (Print) Journal Article Research Support, Non-U.S. Gov't}, abstract = {PURPOSE: To evaluate the potential of photodynamic therapy (PDT) using benzoporphyrin derivative (BPD) for occlusion of subretinal neovascular membranes, the authors studied efficiency and collateral damage of PDT-induced photothrombosis in the rabbit choriocapillary layer. METHOD: Benzoporphyrin derivative, a new photosensitizer, currently in clinical trials for tumor therapy, was used. Low-density lipoprotein served as a carrier to enhance selective targeting of vascular endothelial cells. RESULTS: Complete choriocapillary occlusion was achieved at a BPD dose of 2 mg/kg and a radiant exposure as low as 10 J/cm2. When PDT was performed 3 hours after BPD application, damage to the neural retina was minimal. Only inner photoreceptor segments showed mitochondrial swelling probably secondary to choroidal ischemia. Bruch's membrane remained intact. Retinal pigment epithelium was invariably damaged as seen with other photosensitizers. CONCLUSION: Compared with photocoagulation BPD-PDT allows endothelial-bound intraluminal photothrombosis, sparing important structures such as neural retina and Bruch's membrane. It may thus provide a more selective treatment of juxtafoveal and subfoveal neovascular membranes.}, keywords = {Animals Bruch Membrane/drug effects/pathology/radiation effects Choroid/blood supply Drug Carriers Endothelium, Vascular/drug effects/pathology/radiation effects Lipoproteins, LDL/therapeutic use *Photochemotherapy/methods Photoreceptors/drug effects/pathology/radiation effects Pigment Epithelium of Eye/drug effects/pathology/radiation effects Porphyrins/administration & dosage/*therapeutic use Rabbits Radiation-Sensitizing Agents/administration & dosage/*therapeutic use Retinal Neovascularization/*drug therapy/pathology Retinal Vessels/*drug effects/pathology/radiation effects}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7997334}, year = {1994}, type = {Journal Article} } |
Alfred
Vogel,
M.
Asiyo-Vogel, and
Reginald
Birngruber,
Untersuchungen zur intrastromalen refraktiven Hornhautchirurgie mit Picosekunden-Nd: YAG-Laser-Pulsen., .... Berlin, ALLEMAGNE: Springer, 1994.
Untersuchungen zur intrastromalen refraktiven Hornhautchirurgie mit Picosekunden-Nd: YAG-Laser-Pulsen., .... Berlin, ALLEMAGNE: Springer, 1994.
G.
Hüttmann,
S.
Churio,
S.E.
Braslavsky, and
Reginald
Birngruber,
The Possibility of Measuring Thermal Protein Denaturation by an Optoacoustic Method., in Proc. SPIE , 1994. pp. 202-212.
The Possibility of Measuring Thermal Protein Denaturation by an Optoacoustic Method., in Proc. SPIE , 1994. pp. 202-212.
File: | 12.168030 |
Bibtex: | ![]() @inproceedings{Hüttmann, author = {Hüttmann, G. and Churio, S. and Braslavsky, S.E. and Birngruber, R.}, title = {The Possibility of Measuring Thermal Protein Denaturation by an Optoacoustic Method.}, booktitle = {Proc. SPIE}, volume = {2077}, pages = {202-212}, url = { https://doi.org/10.1117/12.168030}, year = { 1994} } |