Wolfgang Draxinger

Doktorand / PhD Student


Universität zu Lübeck
Institut für Biomedizinische Optik

Maria-Goeppert-Str. 1
23562 Lübeck
Gebäude MFC 1, Raum 2.24

Email:
Phone:
+49 451 3101 3234
Fax:
+49 451 3101 3233



Publikationen

2021

  • P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann: Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples. in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, no. 11630, pp. 66 - 73, SPIE, 2021
    BibTeX Link
    @inproceedings{Strenge2021,
    author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann},
    title = {{Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples}},
    volume = {11630},
    booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
    editor = {Joseph A. Izatt and James G. Fujimoto},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {66 -- 73},
    abstract = {Optical coherence tomography (OCT) has the potential to become an additional imaging modality for surgical guidance in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. Interpretation of the images, however, is still a big challenge. A method to create a labeled OCT dataset based on ex vivo brain samples is introduced. The tissue samples were embedded in an agarose mold giving them a distinctive shape before images were acquired with two OCT systems (spectral domain (SD) and swept source (SS) OCT) and histological sections were created and segmented by a neuropathologist. Based on the given shape, the corresponding OCT images for each histological image can be determined. The transfer of the labels from the histological images onto the OCT images was done with a non-affine image registration approach based on the tissue shape. It was demonstrated that finding OCT images of a tissue sample corresponding to segmented histological images without any color or laser marking is possible. It was also shown that the set labels can be transferred onto OCT images. The accuracy of method is 26 ± 11 pixel, which translates to 192 ± 75 μm for the SS-OCT and 94 ± 43 μm for the SD-OCT. The dataset consists of several hundred labeled OCT images, which can be used to train a classification algorithm.},
    keywords = {AG-Huber_OCT, optical coherence tomography, OCT, image registration, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery},
    year = {2021},
    URL = {hhttps://doi.org/10.1117/12.2578391}
    }
  • S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber: Characterization of the dynamics of an FDML laser during closed-loop cavity length control. in Fiber Lasers XVIII: Technology and Systems, no. 11665, pp. 236 - 241, SPIE, 2021
    BibTeX Link
    @inproceedings{LotzLASE2021,
    author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber},
    title = {{Characterization of the dynamics of an FDML laser during closed-loop cavity length control}},
    volume = {11665},
    booktitle = {Fiber Lasers XVIII: Technology and Systems},
    editor = {Michalis N. Zervas},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {236 -- 241},
    abstract = {In Fourier domain mode locked (FDML) lasers, extremely precise and stable matching of the filter tuning period and light circulation time in the cavity is essential for ultra-low noise operation. During the operation of FDML lasers, the ultra-low noise mode can be lost due to temperature drifts of the already temperature stabilized cavity resulting in increased intensity noise. Until now, the filter frequency is continuously regulated to match the changing light circulation time. However, this causes the filter frequency to constantly change by a few mHz and leads to synchronization issues in cases where a fixed filter frequency is desired. We present an actively cavity length controlled FDML laser and a robust and high precision feedback loop algorithm for maintaining ultra-low noise operation. Instead of adapting the filter frequency, the cavity length is adjusted by a motorized free space beam path to match the fixed filter frequency. The closed-loop system achieves a stability of ~0.18 mHz at a sweep repetition rate of ~418 kHz which corresponds to a ratio of 4×10<sup>-10</sup>. We investigate the coherence properties during the active cavity length adjustments and observe no noise increase compared to fixed cavity length. The cavity length control is fully functional and for the first time, offers the possibility to operate an FDML laser in sweet spot mode at a fixed frequency or phase locked to an external clock. This opens new possibilities for system integration of FDML lasers.},
    keywords = {AG-Huber_FDML, FDML, Fourier domain mode locking, laser beating, tunable laser, optical coherence tomography, OCT},
    year = {2021},
    URL = {hhttps://doi.org/10.1117/12.2578514}
    }
  • P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann: Characterization of brain tumor tissue with 1310 nm optical coherence tomography. in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, no. 11630, pp. 74 - 80, SPIE, 2021
    BibTeX Link
    @inproceedings{Strenge2021A,
    author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann},
    title = {{Characterization of brain tumor tissue with 1310 nm optical coherence tomography}},
    volume = {11630},
    booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},
    editor = {Joseph A. Izatt and James G. Fujimoto},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {74 -- 80},
    abstract = {The separation of tumorous brain tissue and healthy brain tissue is still a big challenge in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. On the basis of a recently created labelled OCT dataset of ex vivo glioblastoma multiforme tumor samples the detection of brain tumor tissue and the identification of zones with varying degrees of infiltration of tumor cells was investigated. The identification was based on the optical properties, which were extracted by an exponential fit function. The results showed that a separation of tumorous tissue and healthy white matter based on these optical properties is possible. A support vector machine was trained on the optical properties to separate tumor from healthy white matter tissue, which achieved a sensitivity of 91% and a specificity of 76% on an independent training dataset.},
    keywords = {AG-Huber_OCT, optical coherence tomography, OCT, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery},
    year = {2021},
    URL = {hhttps://doi.org/10.1117/12.2578409}
    }
  • S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber: Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision. Biomedical Optics Express, no. 12(5), pp. 2604-2616, 2021
    BibTeX Link
    @article{Lotz2021,
       author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber},
       title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision},
       journal = {Biomedical Optics Express},
       volume = {12(5)},
       keywords={AG-Huber_FDML},
       pages = {2604-2616},
       url = {https://doi.org/10.1364/BOE.422898},
       year = {2021},
       type = {Journal Article}
    }
    
  • C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber: A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements. in Fiber Lasers XVIII: Technology and Systems, no. 11665, pp. 242 - 247, SPIE, 2021
    BibTeX Link
    @inproceedings{Grill2021,
    author = {C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber},
    title = {{A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements}},
    volume = {11665},
    booktitle = {Fiber Lasers XVIII: Technology and Systems},
    editor = {Michalis N. Zervas},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {242 -- 247},
    keywords = {AG-Huber_FDML, Fourier domain mode locking, FDML laser, laser beating , tunable laser, optical coherence tomography, OCT},
    year = {2021},
    URL = {hhttps://doi.org/10.1117/12.2578293}
    }

2020

  • Strauch, Matthias and Kolb, Jan Philip and Weng, Daniel and Wacker, Melanie and Draxinger, Wolfgang and Merg, Nadine and Hundt, Jennifer and Karpf, Sebastian and Huber, Robert: Two-photon microscopy for sectioning-free virtual H&E imaging. in 104. Jahrestagung der Deutschen Gesellschaft fuer Pathologie, 2020
    BibTeX
    @InProceedings{Strauch2020,
      author    = {Strauch, Matthias and Kolb, Jan Philip and Weng, Daniel and Wacker, Melanie and Draxinger, Wolfgang and Merg, Nadine and Hundt, Jennifer and Karpf, Sebastian and Huber, Robert},
      booktitle = {104. Jahrestagung der Deutschen Gesellschaft fuer Pathologie},
      title     = {Two-photon microscopy for sectioning-free virtual {H&E} imaging},
      year      = {2020},
      keywords  = {AG-Huber_NL},
    }
  • P. Strenge and B. Lange and C. Grill and W. Draxinger and M. M. Bonsanto and C. Hagel and R. Huber and R. Brinkmann: Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis. in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, no. 11228, pp. 82 - 89, SPIE, 2020
    BibTeX Link Datei
    @inproceedings{Strenge2020,
    author = {P. Strenge and B. Lange and C. Grill and W. Draxinger and M. M. Bonsanto and C. Hagel and R. Huber and R. Brinkmann},
    title = {{Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis}},
    volume = {11228},
    booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV},
    editor = {Joseph A. Izatt and James G. Fujimoto},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {82 -- 89},
    keywords = {AG-Huber_OCT, Optical coherence tomography, OCT, FDML Laser, MHz-OCT, brain tumor, brain imaging, neurosurgery},
    year = {2020},
    
    URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11228/112282O/Segmented-OCT-data-set-for-depth-resolved-brain-tumor-detection/10.1117/12.2545659.short}
    }
    
  • Tom Pfeiffer and Madita Göb and Wolfgang Draxinger and Sebastian Karpf and Jan Philip Kolb and Robert Huber: Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging. Biomed. Opt. Express, no. 11, pp. 6799-6811, OSA, Nov, 2020
    BibTeX Link
    @article{Pfeiffer:20,
    author = {Tom Pfeiffer and Madita G\"{o}b and Wolfgang Draxinger and Sebastian Karpf and Jan Philip Kolb and Robert Huber},
    journal = {Biomed. Opt. Express},
    keywords = {AG-Huber_OCT; High speed imaging; Image quality; Optical coherence tomography; Swept lasers; Swept sources; Systems design},
    number = {11},
    pages = {6799--6811},
    publisher = {OSA},
    title = {Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging},
    volume = {11},
    month = {Nov},
    year = {2020},
    doi = {10.1364/BOE.402477},
    abstract = {In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze them point by point and describe the appropriate solutions. We prove that coherent averaging is possible at MHz OCT-speed without special interferometer designs or digital phase stabilization. We find, that in our system up to \&\#x223C;100x coherent averaging is possible while achieving a sensitivity increase close to the ideal values. This corresponds to a speed reduction from 3.3 MHz to 33 kHz and a sensitivity gain of 20 dB. We show an imaging comparison between coherent and magnitude averaging of a human finger knuckle joint in vivo with 121\&\#x00A0;dB sensitivity for the coherent case. Further, the benefits of computational downscaling in low sensitivity MHz-OCT systems are analyzed.},
    }
    
  • C. Grill, S. Lotz, T. Blömker, D. Kastner, T. Pfeiffer, S. Karpf, M. Schmidt, W. Draxinger C. Jirauschek and R. Huber: Beating of two FDML lasers in real time. in Fiber Lasers XVII: Technology and Systems, no. 11260, pp. 132 - 138, SPIE, 2020
    BibTeX Link Datei
    @inproceedings{Grill2020,
    author = {C. {Grill}, S. {Lotz}, T. {Blömker}, D. {Kastner}, T. {Pfeiffer}, S. {Karpf}, M. {Schmidt}, W. {Draxinger}, C. 
     {Jirauschek} and R. {Huber}},
    title = {{Beating of two FDML lasers in real time}},
    volume = {11260},
    booktitle = {Fiber Lasers XVII: Technology and Systems},
    editor = {Liang Dong},
    organization = {International Society for Optics and Photonics},
    publisher = {SPIE},
    pages = {132 -- 138},
    keywords = {AG-Huber_FDML, FDML laser, fiber lasers, beat signal, OCT, Optical Coherence Tomography, Fourier domain mode locking},
    year = {2020},
    doi = {10.1117/12.2545794},
    
    }
    

2019

  • Julian Klee, Jan Philip Kolb, Christin Grill, Wolfgang Draxinger ,Tom Pfeiffer, Robert Huber: Zero roll-off retinal MHz-OCT using an FDML-laser. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780S, no. 11078, 2019
    BibTeX Link Datei
    @proceeding{Klee2019,
    author = {Julian Klee, Jan Philip Kolb, Christin Grill, Wolfgang Draxinger ,Tom Pfeiffer, Robert Huber},
    title = {Zero roll-off retinal MHz-OCT using an FDML-laser},
    volume = {11078},
    year = {2019},
    
    URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527034/Zero-roll-off-retinal-MHz-OCT-using-an-FDML-laser/10.1117/12.2527034.short},
    keywords = {AG-Huber_OCT},
    booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780S},
    eprint = {}
    }
    
  • Kolb, J P;Weng, D;Hakert, H;Eibl, M;Draxinger, W;Meyer, T;Gottschall, T;Brinkmann, R;Birngruber, R;Popp, J;Limpert, J;Karpf, S and Huber, R: Virtual HE histology by fiber-based picosecond two-photon microscopy. in Multiphoton Microscopy in the Biomedical Sciences XIX Proc. SPIE,10882, pp. 108822F, International Society for Optics and Photonics, 2019
    BibTeX Link Datei
    @inproceedings{Kolb2019/2,
       author = {Kolb, J P;Weng, D;Hakert, H;Eibl, M;Draxinger, W;Meyer, T;Gottschall, T;Brinkmann, R;Birngruber, R;Popp, J;Limpert, J;Karpf, S and Huber, R},
       title = {Virtual HE histology by fiber-based picosecond two-photon microscopy},
       booktitle = {Multiphoton Microscopy in the Biomedical Sciences XIX} {Proc. SPIE,10882},
       editor = {Ammasi Periasamy; Peter T. C. So; Karsten König},
       publisher = { International Society for Optics and Photonics},
       year = {2019},
       pages = {108822F},
    keywords = {AG-Huber_NL},
       
    doi = {10.1117/12.2507866},
       type = {Conference Proceedings}
    }
    
  • Strauch, Matthias and Kolb, Jan Philip and Weng, Daniel and Wacker, Melanie and Draxinger, Wolfgang and Karpf, Sebastian and Huber, Robert: Sectioning-Free Virtual H&E Imaging of Tissue Samples with Two-Photon Microscopy. in 31st Congress of the ESP, 2019
    BibTeX
    @InProceedings{Strauch2019,
      author    = {Strauch, Matthias and Kolb, Jan Philip and Weng, Daniel and Wacker, Melanie and Draxinger, Wolfgang and Karpf, Sebastian and Huber, Robert},
      booktitle = {31st Congress of the ESP},
      title     = {Sectioning-Free Virtual H&E Imaging of Tissue Samples with Two-Photon Microscopy},
      year      = {2019},
      keywords  = {AG-Huber_NL},
    }
  • Miura, Y; Draxinger, W; Grill, C; Pfeiffer, T; Grisanti, S and Huber, R: MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780E, no. 11078, 2019
    BibTeX Link Datei
    @proceeding{Miura2019,
    author = { Miura, Y; Draxinger, W; Grill, C; Pfeiffer, T; Grisanti, S and Huber, R},
    title = { MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye},
    volume = {11078},
    year = {2019},
    
    URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527123/MHz-OCT-for-low-latency-virtual-reality-guided-surgery/10.1117/12.2527123.short},
    keywords = {AG-Huber_OCT},
    booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110780E},
    eprint = {}
    }
    
  • Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R: Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates. J pone 14(3), pp. e0213144, 2019
    BibTeX Link
    @article{Kolb2019,
       author = {Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R},
       title = {Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates},
       journal = {J pone} {14(3)},
     keywords = {AG-Huber_OCT},
       url = {https://doi.org/10.1371/journal.pone.0213144},
       pages = {e0213144},
       ISSN = {1932-6203},
       
       year = {2019},
       type = {Journal Article}
    }
    
  • Kolb, Jan Philip and Strauch, Matthias and Weng, Daniel and Hakert, Hubertus and Draxinger, Wolfgang and Merg, Nadine and Brinkmann, Ralf and Birngruber, Reginald and Hundt, Jennifer and Karpf, Sebastian and Huber, Robert: Fiber-Based Sub-Nanosecond Two-Photon Microscopy for Virtual H&E Histology. in European Conference on Biomedical Optics (ECBO), 2019
    BibTeX
    @InProceedings{Kolb2019,
      author    = {Kolb, Jan Philip and Strauch, Matthias and Weng, Daniel and Hakert, Hubertus and Draxinger, Wolfgang and Merg, Nadine and Brinkmann, Ralf and Birngruber, Reginald and Hundt, Jennifer and Karpf, Sebastian and Huber, Robert},
      booktitle = {European Conference on Biomedical Optics (ECBO)},
      title     = {Fiber-Based Sub-Nanosecond Two-Photon Microscopy for Virtual H&E Histology},
      year      = {2019},
      keywords  = {AG-Huber_NL},
    }
  • Strenge,P; Lange,B; Grill, C; Draxinger, W; Danicke, V; Theisen-Kunde, D; Bonsanto, M; Huber, R and Brinkmann R: Ex vivo and in vivo imaging of human brain tissue with different OCT systems. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110781C, no. 11078, 2019
    BibTeX Link Datei
    @proceeding{Strenge2019,
    author = {Strenge,P; Lange,B; Grill, C; Draxinger, W; Danicke, V; Theisen-Kunde, D; Bonsanto, M; Huber, R and Brinkmann R},
    title = {Ex vivo and in vivo imaging of human brain tissue with different OCT systems},
    volume = {11078},
    year = {2019},
    
    URL = {  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2526932/Ex-vivo-and-in-vivo-imaging-of-human-brain-tissue/10.1117/12.2526932.short},
    keywords = {AG-Huber_OCT},
    booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 110781C},
    eprint = {}
    }
    
  • Draxinger, D; Miura, Y; Grill, C; Pfeiffer, T and Huber, R: A real-time video-rate 4D MHz-OCT microscope with high definition and low latency virtual reality display. in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 1107802, no. 11078, 2019
    BibTeX Link Poster
    @proceeding{Draxinger2019,
    author = {Draxinger, D; Miura, Y; Grill, C; Pfeiffer, T and Huber, R},
    title = {A real-time video-rate 4D MHz-OCT microscope with high definition and low latency virtual reality display},
    volume = {11078},
    year = {2019},
    url={  https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527177/A-real-time-video-rate-4D-MHz-OCT-microscope-with/10.1117/12.2527177.short}
    
    keywords = {AG-Huber_OCT},
    booktitle =    {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III, 1107802},
    eprint = {}
    }
    

2018

  • Pfeiffer, T; Petermann, M; Draxinger, W; Jirauschek, C and Huber, R: Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography. Biomed Opt Expr 9(9), pp. 4130-4148, 2018
    BibTeX Link
    @article{Pfeiffer2018,
       author = {Pfeiffer, T; Petermann, M; Draxinger, W; Jirauschek, C and Huber, R},
       title = {Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography},
       journal = {Biomed Opt Expr} {9(9)},
      
       pages = {4130-4148},
     DOI = {10.1364/BOE.9.004130},  
    
       year = {2018},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Journal Article}
    }
    
  • Schulz-Hildebrandt, H; Pfeiffer, T; Eixmann, T; Lohmann, S; Ahrens, M; Rehra, J; Draxinger, W; König, P; Huber, R and Gereon Hüttmann: High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography. Op Lett 43(18), pp. 4386-4389, 2018
    BibTeX Link
    @article{Schulz-Hildebrandt2018b,
    title = {High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography},
    author = { Schulz-Hildebrandt, H; Pfeiffer, T; Eixmann, T; Lohmann, S; Ahrens, M; Rehra, J; Draxinger, W; K\"{o}nig, P; Huber, R and Gereon H\"{u}ttmann},
    url = {https://doi.org/10.1364/OL.43.004386},
    
    
    year = {2018},
    date = {2018-09-05},
    journal = {Op Lett} {43(18)},
    
    pages = {4386-4389},
    abstract = {We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 μm was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in spirals for scanning the sample, the beam quality remains constant over the entire field of view with a diameter of 0.8 mm. The scanning frequency was adjusted to 1.22 kHz for use with a 3.28 MHz Fourier domain mode locked OCT system. Densely sampled volumes have been imaged at a rate of 6 volumes per second.
    
    © 2018 Optical Society of America},
    keywords = {Endoskope, AG-Huber_OCT},
    pubstate = {published},
    tppubtype = {article}
    }

2017

  • Wang, T; Pfeiffer, T; Wu, M; Wieser, W; Amenta, G; Draxinger, W; van der Steen, A F W; Huber, Robert and Soest, G van: Thermo-elastic optical coherence tomography. Opt Lett 42(17), pp. 3466-3469, 2017
    BibTeX Link
    @article{Wang2017,
       author = {Wang, T; Pfeiffer, T; Wu, M; Wieser, W; Amenta, G; Draxinger, W; van der Steen, A F W; Huber, Robert and Soest, G van},
       title = {Thermo-elastic optical coherence tomography},
       journal = {Opt Lett} {42(17)},
      
       pages = {3466-3469},
       DOI = {10.1364/OL.42.003466},
       year = {2017},
    keywords = {AG-Huber_OCT},
       type = {Journal Article}
    }
    
  • Wang, Tianshi and Pfeiffer, Tom and Wu, Min and Wieser, Wolfgang and Draxinger, Wolfgang and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs: Short pulse laser induced thermo-elastic deformation imaging. in Proc. SPIE, no. 10062, pp. 100620C-100620C-4, 2017
    BibTeX Link
    @inproceedings{Wang2017,
       author = {Wang, Tianshi and Pfeiffer, Tom and Wu, Min and Wieser, Wolfgang and Draxinger, Wolfgang and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs},
       title = {Short pulse laser induced thermo-elastic deformation imaging},
    booktitle = Proc. SPIE},
      volume = {10062},
      year = {2017},
       pages = {100620C-100620C-4},
      url = {http://dx.doi.org/10.1117/12.2251502},
    keywords = {AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
    
  • Pfeiffer, T; Draxinger, W; Grill, C and Huber, R: Long-range live 3D-OCT at different spectral zoom levels. in Proc. SPIE 10416, pp. 104160L1-4, 2017
    BibTeX Link
    @inproceedings{Pfeiffer2017,
       author = {Pfeiffer, T; Draxinger, W; Grill, C and Huber, R},
       title = {Long-range live 3D-OCT at different spectral zoom levels},
       booktitle = {Proc. SPIE} {10416},
      url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10416/1/Long-range-live-3D-OCT-at-different-spectral-zoom-levels/10.1117/12.2287484.short?SSO=1},
       pages = {104160L1-4},
       year = {2017},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Pfeiffer, Tom and Draxinger, Wolfgang and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Huber, Robert: Analysis of FDML lasers with meter range coherence. in Proc. SPIE, no. 10053, pp. 100531T-100531T-6, 2017
    BibTeX Link
    @inproceedings{Pfeiffer2017,
       author = {Pfeiffer, Tom and Draxinger, Wolfgang and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Huber, Robert},
       title = {Analysis of FDML lasers with meter range coherence},
       booktitle = {Proc. SPIE},
       volume = {10053},
       pages = {100531T-100531T-6},
        url = {http://dx.doi.org/10.1117/12.2254792},
    
      year = {2017},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    

2015

  • Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert: High definition in vivo retinal volumetric video rate OCT at 0.6 Giga-voxels per second. in Proc. SPIE, no. 9541, pp. 95410Z-95410Z-8, 2015
    BibTeX Link
    @inproceedings{HU_2015_Kolb_d,
    author = {Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert},
    title = {High definition in vivo retinal volumetric video rate OCT at 0.6 Giga-voxels per second },
    booktitle = {Proc. SPIE },
    type = {Conference Proceedings},
    volume = {9541},
    pages = {95410Z-95410Z-8},
    year = {2015},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
    doi = {10.1117/12.2183768}
    }
  • Wieser, Wolfgang and Klein, Thomas and Draxinger, Wolfgang and Huber, Robert: Fully automated 1.5 MHz FDML laser with more than 100mW output power at 1310 nm. in Proc. SPIE, no. 9541, pp. 954116-954116-7, 2015
    BibTeX Link
    @inproceedings{HU_2015_Wieser_a,
    author = {Wieser, Wolfgang and Klein, Thomas and Draxinger, Wolfgang and Huber, Robert},
    title = { Fully automated 1.5 MHz FDML laser with more than 100mW output power at 1310 nm },
    booktitle = {Proc. SPIE },
    type = {Conference Proceedings},
    volume = {9541},
    pages = {954116-954116-7},
    year = {2015},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
    doi = {10.1117/12.2183431}
    }
  • Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert: Full volumetric video rate OCT of the posterior eye with up to 195.2 volumes/s. in Proc. SPIE, no. 9312, pp. 931202-931202-7, 2015
    BibTeX Link
    @inproceedings{Kolb2015 ,
       author = {Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert },
       title = {Full volumetric video rate OCT of the posterior eye with up to 195.2 volumes/s},
       volume = {9312},
    Year={2015},
       pages = {931202-931202-7 },
       DOI = {10.1117/12.2077147 },
       booktitle = {Proc. SPIE },
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Mohler, Kathrin J. and Draxinger, Wolfgang and Klein, Thomas and Kolb, Jan Philip and Wieser, Wolfgang and Haritoglou, Christos and Kampik, Anselm and Fujimoto, James G. and Neubauer, Aljoscha S. and Huber, Robert and Wolf, Armin: Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm60° High-Definition MHz-OCT Imaging of the Choroid. Investigative Ophthalmology & Visual Science, no. 56, pp. 6284-6293, 2015
    BibTeX Link
    @article{HU_Mohler_2015,
    author = {Mohler, Kathrin J. and Draxinger, Wolfgang and Klein, Thomas and Kolb, Jan Philip and Wieser, Wolfgang and Haritoglou, Christos and Kampik, Anselm and Fujimoto, James G. and Neubauer, Aljoscha S. and Huber, Robert and Wolf, Armin},
    title = {Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm60° High-Definition MHz-OCT Imaging of the Choroid},
    journal = {Investigative Ophthalmology & Visual Science},
    volume = {56},
    number = {11},
    pages = {6284--6293},
    year = {2015},
    doi = {10.1167/iovs.15-16670},
    keywords = {AG-Huber_OCT},
    eprint = {/data/Journals/IOVS/934564/i1552-5783-56-11-6284.pdf}
    }

2014

  • Klein, Thomas and Draxinger, Wolfgang and Mohler, Kathrin and Kolb, Jan Philip and Wieser, Wolfgang and Kampik, Anselm and Neubauer, Aljoscha S. and Wolf, Armin and Huber, Robert: Wide-field choroidal thickness and en-face maps of patients created with MHz-OCT. Investigative Ophthalmology & Visual Science, no. 55, pp. 1620-1620, 2014
    BibTeX Link
    @article{Klein2014,
       author = {Klein, Thomas and Draxinger, Wolfgang and Mohler, Kathrin and Kolb, Jan Philip and Wieser, Wolfgang and Kampik, Anselm and Neubauer, Aljoscha S. and Wolf, Armin and Huber, Robert},
       title = {Wide-field choroidal thickness and en-face maps of patients created with MHz-OCT},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {55},
       number = {13},
       pages = {1620-1620},
       abstract = { PurposeTo study the feasibility of simultaneous peripheral and central choroidal thickness measurement and en-face visualization in patients with a variety of diseases, using a single high-resolution wide-field MHz-OCT dataset spanning more than 50 degrees field of view.  MethodsIn this retrospective study, choroidal morphology of 29 patients imaged with MHz-OCT was assessed. MHz-OCT is a custom SS-OCT operating at 1060nm and an axial line rate of 1.68MHz. The high speed, more than 30 times faster than current commercial devices, enabled a very high resolution scan protocol of 2088x1024 A-scans over a wide field of ~60 degrees. However, due to the very high speed, signal strength is lower compared to slower devices. Hence, thickness and structure maps were only created for selected datasets: The positions of Bruch’s membrane and choroid sclera junction were determined manually by a trained observer a subset of all A-scans, from which thickness and intensity maps were created.  ResultsDespite relative low signal strength, the choroid sclera junction could be clearly observed over the entire unshadowed image area in 15 of 29 patients. Apart from shadowing, visibility of this junction shows strong variation even within a single dataset due to varying retinal thickness, eye-blinks, saccades and retinal curvature. Thus, thickness could be evaluated at least in some areas for all 29 patients, especially in the periphery. Moreover, choroidal thickness varied considerably intra- and interindividually. In two patients, abrupt changes of the choroid were observed in the temporal periphery, which may resemble morphology or imaging artifact. In addition to thickness, en-face choroidal structure maps were extracted from the segmented OCT datasets. Visibility of choroidal vasculature in these maps correlates with choroidal thickness.  ConclusionsChoroidal thickness and structure in patients could be visualized over large areas for the first time. Due to focal choroidal thickness changes with large thickness gradients, high-density scan protocols may be favorable for OCT-based investigations of the choroid. En-face images of the choroid can be extracted from these high-resolution datasets, but the influence of choroidal thickness on the image information should be taken into account. Choroidal en-face image (top), color-coded thickness map with superimposed structural image (middle) and OCT B-frame (bottom) for two eyes (A,B).},
       ISSN = {1552-5783},
       url = {http://dx.doi.org/},
       year = {2014},
    keywords = {AG-Huber_OCT},
       type = {Journal Article}
    }
    
  • Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert: High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s. Biomedical optics express, no. 5, pp. 2963-77, p,, 2014
    BibTeX Link Link
    @Article{HU_2014_Wieser_a,
      Title                    = {{High definition live 3D-OCT in vivo: design and evaluation of a 4D OCT engine with 1 GVoxel/s}},
      Author                   = {Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert},
      Journal                  = {Biomedical optics express},
      Year                     = {2014},
    
      Month                    = sep,
      Number                   = {9},
      Pages                    = {2963--77},
      Volume                   = {5},
    
      Doi                      = {10.1364/BOE.5.002963},
      ISSN                     = {2156-7085},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
      Url                      = {http://www.opticsinfobase.org/boe/abstract.cfm?uri=boe-5-9-2963}
    }
  • Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert: A 4-D OCT Engine with 1 GVoxel/s. Optics and Photonics News, no. 25, pp. 36, OSA, c,, 2014
    BibTeX Link
    @Article{HU_2014_Wieser_b,
      Title                    = {{A 4-D OCT Engine with 1 GVoxel/s}},
      Author                   = {Wieser, Wolfgang and Draxinger, Wolfgang and Klein, Thomas and Karpf, Sebastian and Pfeiffer, Tom and Huber, Robert},
      Journal                  = {Optics and Photonics News},
      Year                     = {2014},
    
      Month                    = dec,
      Number                   = {12},
      Pages                    = {36 },
      Volume                   = {25},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
    
      Publisher                = {OSA},
      Url                      = { http://www.osa-opn.org/home/articles/volume_25/december_2014/extras/a_4-d_oct_engine_with_1_gvoxel_s/#.VcH21Pl5raw}
    }

  • Wang, Tianshi;Pfeiffer, Tom;Wieser, Wolfgang;van Beusekom, Heleen;Draxinger, Wolfgang;van der Steen, Antonius FW;Huber, Robert and van Soest, Gijs: Thermo-elastic optical coherence tomography. in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, no. 10867, pp. 108672C, International Society for Optics and Photonics,
    BibTeX Link
    @inproceedings{Wang2019-1,
       author = {Wang, Tianshi;Pfeiffer, Tom;Wieser, Wolfgang;van Beusekom, Heleen;Draxinger, Wolfgang;van der Steen, Antonius FW;Huber, Robert and van Soest, Gijs},
       title = {Thermo-elastic optical coherence tomography},
       booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII},
       publisher = {International Society for Optics and Photonics},
       volume = {10867},
       pages = {108672C},
       type = {Conference Proceedings}
    }