Dr. rer. nat. Jan Philip Kolb

Postdoc


BMO, AG-Huber
Universität zu Lübeck
Maria-Goeppert-Str. 1
23562 Lübeck

Gebäude MFC1, Raum 1

Email:
Phone:
+49 (0)451 3101 3229/3234(lab)
Fax:
+49 (0)451 3101 3233


Publikationen

2019

  • Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R: Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates. J pone 14(3), pp. e0213144, 2019
    BibTeX Link
    @article{Kolb2019,
       author = {Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R},
       title = {Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates},
       journal = {J pone} {14(3)},
     keywords = {AG-Huber_OCT},
       url = {https://doi.org/10.1371/journal.pone.0213144},
       pages = {e0213144},
       ISSN = {1932-6203},
       
       year = {2019},
       type = {Journal Article}
    }
    
  • Kolb, J P;Weng, D;Hakert, H;Eibl, M;Draxinger, W;Meyer, T;Gottschall, T;Brinkmann, R;Birngruber, R and Popp, J: Virtual HE histology by fiber-based picosecond two-photon microscopy. in Multiphoton Microscopy in the Biomedical Sciences XIX Proc. SPIE,10882, pp. 108822F, International Society for Optics and Photonics, 2019
    BibTeX Link
    @inproceedings{Kolb2019/2,
       author = {Kolb, J P;Weng, D;Hakert, H;Eibl, M;Draxinger, W;Meyer, T;Gottschall, T;Brinkmann, R;Birngruber, R and Popp, J},
       title = {Virtual HE histology by fiber-based picosecond two-photon microscopy},
       booktitle = {Multiphoton Microscopy in the Biomedical Sciences XIX} {Proc. SPIE,10882},
       editor = {Ammasi Periasamy; Peter T. C. So; Karsten König},
       publisher = { International Society for Optics and Photonics},
       year = {2019},
       pages = {108822F},
    keywords = {AG-Huber_NL},
       
    doi = {10.1117/12.2507866},
       type = {Conference Proceedings}
    }
    

2018

  • Eibl ,M; Weng, D; Hakert, H; Kolb, J P; Pfeiffer, T; Hundt, J E; Huber, R and Karpf, S: Wavelength agile multi-photon microscopy with a fiber amplified diode laser. Biomedical Optics Express 9(12), pp. 6273-6282, 2018
    BibTeX Link
    @article{Eibl2018,
    author = { Eibl ,M; Weng, D; Hakert, H; Kolb, J P; Pfeiffer, T; Hundt, J E; Huber, R and Karpf, S},
    title = {Wavelength agile multi-photon microscopy with a fiber amplified diode laser},
    journal = {Biomedical Optics Express} {9(12)},
    keywords = {AG-Huber_NL},
    year = {2018},
    pages = {6273--6282},
    doi = {10.1364/BOE.9.006273},
    }
    
  • Maertz, J; Kolb, J P; Klein, T; Mohler, K J; Eibl, M; Wieser, W; Huber, R; Priglinger, S and Wolf, A: Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm. Graefe`s Archive for Clinical and Experimental Ophthalmology 256(2), pp. 289-298, 2018
    BibTeX Link Link
    @article{Maertz2018,
       author = {Maertz, J; Kolb, J P; Klein, T; Mohler, K J; Eibl, M; Wieser, W; Huber, R; Priglinger, S and Wolf, A},
       title = {Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm},
       journal = {Graefe's Archive for Clinical and Experimental Ophthalmology} {256(2)},
       volume = ,
       number = {2},
       pages = {289-298},
       DOI = {10.1007/s00417-017-3857-9},
       url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032262413&doi=10.1007%2fs00417-017-3857-9&partnerID=40&md5=a46c315f12cf5e633ea0f7e644116eb3},
       year = {2018},
       Keywords= {En face imaging, Optical coherence tomography, Swept-source OCT, Megahertz OCT, 3D rendering, Optic disc, Optic disc pit, Optic disc pit maculopathy, AG-Huber_OCT}
       type = {Journal Article}
    }
  • Kolb, J P; Pfeiffer, T; Eibl, M; Hakert, H and Huber, R: High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates. Biomed Opt Expr 9(1), pp. 120-130, 2018
    BibTeX Link
    @article{Kolb2018,
       author = {Kolb, J P; Pfeiffer, T; Eibl, M; Hakert, H and Huber, R},
       title = {High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates},
       journal = {Biomed Opt Expr} {9(1)},
       
       pages = {120-130},
       DOI = {10.1364/BOE.9.000120},
       year = {2018},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Journal Article}
    }
    

2017

  • Eibl, M; Karpf, S; Hakert, H; Blömker, T; Kolb, J P; Jirauschek, C and Huber, R: Pulse-to-pulse wavelength switching of a nanosecond fiber laser by four-wave mixing seeded stimulated Raman amplification. Opt Lett 42(21), pp. 4406-4409, OSA, Nov, 2017
    BibTeX Link
    @article{2017Eibl,
    author = {Eibl, M; Karpf, S; Hakert, H; Bl\"{o}mker, T; Kolb, J P; Jirauschek, C and Huber, R},
    journal = {Opt Lett} {42(21)},
    keywords = {NLI, TPEF, Multiphoton, AG-Huber_NL},
    
    pages = {4406--4409},
    publisher = {OSA},
    title = {Pulse-to-pulse wavelength switching of a nanosecond fiber laser by four-wave mixing seeded stimulated Raman amplification},
    
    month = {Nov},
    year = {2017},
    doi = {10.1364/OL.42.004406},
    }
    
  • Kolb, J P; Klee, J; Pfeiffer, Tand Huber, R: 1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full eye length and retinal ultra-widefield OCT. in Proc. SPIE 10416, pp. 104160J-104160J-6, 2017
    BibTeX Link
    @inproceedings{Kolb2017,
       author = {Kolb, J P; Klee, J; Pfeiffer, Tand Huber, R},
       title = {1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full     eye length and retinal ultra-widefield OCT},
      booktitle = {Proc. SPIE} {10416},
    
      pages = {104160J-104160J-6},
      year = {2017},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       url = {http://dx.doi.org/10.1117/12.2286854},
       type = {Conference Proceedings}
    }
    
  • Eibl, M; Karpf, S; Hakert, H; Weng, D; Pfeiffer, T; Kolb, J P and Huber, R: Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup. in Proc. SPIE 10414, pp. 1041403-1041403-7, 2017
    BibTeX Link
    @inproceedings{Eibl2017,
       author = {Eibl, M; Karpf, S; Hakert, H; Weng, D; Pfeiffer, T; Kolb, J P and Huber, R},
       title = {Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup},
      booktitle = {Proc. SPIE} {10414},
      
      year = {2017},
    keywords = {AG-Huber_NL},
       pages = {1041403-1041403-7},
       url = {http://dx.doi.org/10.1117/12.2286035},
       type = {Conference Proceedings}
    }
    
  • Maertz, J. and Mohler, K. J. and Kolb, J. P. and Klein, T. and Neubauer, A. and Kampik, A. and Priglinger, S. and Wieser, W. and Huber, R. and Wolf, A.: INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes. Retina, no. 37, pp. 906-914, 2017
    BibTeX Link
    @article{Maertz2017,
       author = {Maertz, J. and Mohler, K. J. and Kolb, J. P. and Klein, T. and Neubauer, A. and Kampik, A. and Priglinger, S. and Wieser, W. and Huber, R. and Wolf, A.},
       title = {INTRAPAPILLARY PROLIFERATION IN OPTIC DISK PITS: Clinical Findings and Time-Related Changes},
       journal = {Retina},
       volume = {37},
       number = {5},
       pages = {906-914},
       DOI = {10.1097/iae.0000000000001260},
       year = {2017},
    keywords = {AG-Huber_OCT},
       type = {Journal Article}
    }
    
  • Matthias Eibl and Sebastian Karpf and Daniel Weng and Hubertus Hakert and Tom Pfeiffer and Jan Philip Kolb and Robert Huber: Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate. Biomedical Optics Express, no. 8, pp. 3132-3142, OSA, Jul, 2017
    BibTeX Link
    @article{HU_2017_Eibla_BOE,
    author = {Matthias Eibl and Sebastian Karpf and Daniel Weng and Hubertus Hakert and Tom Pfeiffer and Jan Philip Kolb and Robert Huber},
    journal = {Biomedical Optics Express},
    number = {7},
    pages = {3132--3142},
    publisher = {OSA},
    title = {Single pulse two photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate},
    volume = {8},
    month = {Jul},
    year = {2017},
    keywords = {AG-Huber_NL},
    doi = {10.1364/BOE.8.003132}
    }
    

2016

  • Pfeiffer, Tom and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Kolb, Jan-Phillip and Eibl, Matthias and Huber, Robert: Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging. Proc. SPIE, no. 9697, pp. 96970S-96970S-5, 2015
    BibTeX Link
    @inproceedings{Pfeiffer2016,
       author = {Pfeiffer, Tom and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Kolb, Jan-Phillip and Eibl, Matthias and Huber, Robert},
       title = {Flexible A-scan rate MHz OCT: computational downscaling by coherent averaging},
    Year={  2015}
       journal = {Proc. SPIE},
       volume = {9697},
       pages = {96970S-96970S-5},
       note = {10.1117/12.2214788},
       abstract = {In order to realize fast OCT-systems with adjustable line rate, we investigate averaging of image data from an FDML based MHz-OCT-system. The line rate can be reduced in software and traded in for increased system sensitivity and image quality. We compare coherent and incoherent averaging to effectively scale down the system speed of a 3.2 MHz FDML OCT system to around 100 kHz in postprocessing. We demonstrate that coherent averaging is possible with MHz systems without special interferometer designs or digital phase stabilisation. We show OCT images of a human finger knuckle joint in vivo with very high quality and deep penetration.},
       url = {http://dx.doi.org/10.1117/12.2214788},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Kolb, Jan Philip and Klein, Thomas and Eibl, Matthias and Pfeiffer, Tom and Wieser, Wolfgang and Huber, Robert: Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm. in Proc. SPIE, no. 9697, pp. 969703-969703-8, 2016
    BibTeX Link
    @inproceedings{Kolb2016,
       author = {Kolb, Jan Philip and Klein, Thomas and Eibl, Matthias and Pfeiffer, Tom and Wieser, Wolfgang and Huber, Robert},
       title = {Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm},
       booktitle = {Proc. SPIE},
       volume = {9697},
    
       pages = {969703-969703-8},
       year= { 2016}
       note = {10.1117/12.2214758},
       abstract = {We present a new design of a Fourier Domain Mode Locked laser (FDML laser), which provides a new record in sweep range at ~1μm center wavelength: At the fundamental sweep rate of 2x417 kHz we reach 143nm bandwidth and 120nm with 4x buffering at 1.67MHz sweep rate. The latter configuration of our system is characterized: The FWHM of the point spread function (PSF) of a mirror is 5.6μm (in tissue). Human in vivo retinal imaging is performed with the MHz laser showing more details in vascular structures. Here we could measure an axial resolution of 6.0μm by determining the FWHM of specular reflex in the image. Additionally, challenges related to such a high sweep bandwidth such as water absorption are investigated.},
       url = {http://dx.doi.org/10.1117/12.2214758},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    

2015

  • Mohler, Kathrin J. and Draxinger, Wolfgang and Klein, Thomas and Kolb, Jan Philip and Wieser, Wolfgang and Haritoglou, Christos and Kampik, Anselm and Fujimoto, James G. and Neubauer, Aljoscha S. and Huber, Robert and Wolf, Armin: Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm60° High-Definition MHz-OCT Imaging of the Choroid. Investigative Ophthalmology & Visual Science, no. 56, pp. 6284-6293, 2015
    BibTeX Link
    @article{HU_Mohler_2015,
    author = {Mohler, Kathrin J. and Draxinger, Wolfgang and Klein, Thomas and Kolb, Jan Philip and Wieser, Wolfgang and Haritoglou, Christos and Kampik, Anselm and Fujimoto, James G. and Neubauer, Aljoscha S. and Huber, Robert and Wolf, Armin},
    title = {Combined 60° Wide-Field Choroidal Thickness Maps and High-Definition En Face Vasculature Visualization Using Swept-Source Megahertz OCT at 1050 nm60° High-Definition MHz-OCT Imaging of the Choroid},
    journal = {Investigative Ophthalmology & Visual Science},
    volume = {56},
    number = {11},
    pages = {6284--6293},
    year = {2015},
    doi = {10.1167/iovs.15-16670},
    keywords = {AG-Huber_OCT},
    eprint = {/data/Journals/IOVS/934564/i1552-5783-56-11-6284.pdf}
    }
  • Reznicek, Lukas and Kolb, Jan P. and Klein, Thomas and Mohler, Kathrin J. and Wieser, Wolfgang and Huber, Robert and Kernt, Marcus and Märtz, Josef and Neubauer, Aljoscha S.: Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy. Journal of Diabetes Research, no. 2015, Article ID 305084, pp. 1-5, 2015
    BibTeX Link Link
    @article{Reznicek2015,
       author = {Reznicek, Lukas and Kolb, Jan P. and Klein, Thomas and Mohler, Kathrin J. and Wieser, Wolfgang and Huber, Robert and Kernt, Marcus and Märtz, Josef and Neubauer, Aljoscha S.},
       title = {Wide-Field Megahertz OCT Imaging of Patients with Diabetic Retinopathy},
       journal = {Journal of Diabetes Research},
       volume = {2015, Article ID 305084},
       pages = {1-5},
       DOI = {10.1155/2015/305084},
       url = {http://dx.doi.org/10.1155/2015/305084},
       year = {2015},
    keywords = {AG-Huber_OCT},
       type = {Journal Article}
    
    }
    
    
  • Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert: High definition in vivo retinal volumetric video rate OCT at 0.6 Giga-voxels per second. in Proc. SPIE, no. 9541, pp. 95410Z-95410Z-8, 2015
    BibTeX Link
    @inproceedings{HU_2015_Kolb_d,
    author = {Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert},
    title = {High definition in vivo retinal volumetric video rate OCT at 0.6 Giga-voxels per second },
    booktitle = {Proc. SPIE },
    type = {Conference Proceedings},
    volume = {9541},
    pages = {95410Z-95410Z-8},
    year = {2015},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
    doi = {10.1117/12.2183768}
    }
  • Jan Philip Kolb and Thomas Klein and Corinna L. Kufner and Wolfgang Wieser and Aljoscha S. Neubauer and Huber, Robert: Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle. Biomed. Opt. Express, no. 6, pp. 1534-1552, May, 2015
    BibTeX Link
    @article{HU_2015_Kolb_c, 
    author = {Jan Philip Kolb and Thomas Klein and Corinna L. Kufner and Wolfgang Wieser and Aljoscha S. Neubauer and Huber, Robert}, 
    journal = {Biomed. Opt. Express}, 
    number = {5}, 
    pages = {1534--1552}, 
    title = {Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle}, 
    Keywords = {AG-Huber_FDML, AG-Huber_OCT},
    volume = {6}, 
    month = {May},
    year = {2015},
    doi = {10.1364/BOE.6.001534}
    }
    
    
    
  • Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert: Full volumetric video rate OCT of the posterior eye with up to 195.2 volumes/s. in Proc. SPIE, no. 9312, pp. 931202-931202-7, 2015
    BibTeX Link
    @inproceedings{Kolb2015 ,
       author = {Kolb, Jan Philip and Klein, Thomas and Wieser, Wolfgang and Draxinger, Wolfgang and Huber, Robert },
       title = {Full volumetric video rate OCT of the posterior eye with up to 195.2 volumes/s},
       volume = {9312},
    Year={2015},
       pages = {931202-931202-7 },
       DOI = {10.1117/12.2077147 },
       booktitle = {Proc. SPIE },
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Kolb, Jan Philip and Schwarz, Philipp and Klein, Thomas and Wieser, Wolfgang and Huber, Robert: Dual parametric compounding approach for speckle reduction in OCT. in Proc. SPIE, no. 9312, pp. 93123G-93123G-7, 2015
    BibTeX Link
    @inproceedings{Kolb2015,
       author = {Kolb, Jan Philip and Schwarz, Philipp and Klein, Thomas and Wieser, Wolfgang and Huber, Robert},
       title = {Dual parametric compounding approach for speckle reduction in OCT},
    Year={2015},
       volume = {9312},
       pages = {93123G-93123G-7},
       DOI = {10.1117/12.2077659},
       booktitle = {Proc. SPIE},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    

2014

  • Kolb, Jan Philip and Klein, Thomas and Mohler, Kathrin and Wieser, Wolfgang and Reznicek, Lukas and Kernt, Marcus and Kampik, Anselm and Neubauer, Aljoscha S. and Huber, Robert: Widefield Megahertz (MHz) OCT of diabetic retinopathy. Investigative Ophthalmology & Visual Science, no. 55, pp. 5018-5018, 2014
    BibTeX Link
    @article{Kolb2014,
       author = {Kolb, Jan Philip and Klein, Thomas and Mohler, Kathrin and Wieser, Wolfgang and Reznicek, Lukas and Kernt, Marcus and Kampik, Anselm and Neubauer, Aljoscha S. and Huber, Robert},
       title = {Widefield Megahertz (MHz) OCT of diabetic retinopathy},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {55},
       number = {13},
       pages = {5018-5018},
       abstract = { PurposeTo investigate morphological appearance of diabetic retinopathy and laser effects in panretinal laser photocoagulation with a widefield MHz OCT (60° field of view, 120° center angle).  MethodsA custom swept-source OCT device with a 1060nm Fourier-domain mode-locked laser source achieving a line rate of 1.68MHz was used to investigate 15 consecutive patients with diabetic retinopathy. Within 1.82s datasets consisting of 2088x1024 A-scans over 60° were acquired. The densely sampled three dimensional datasets were investigated in various B-Scan cross-sections as well as en-face images and 3D reconstructions. Selected findings were compared with SLO images from a widefield SLO (Optos, Dunfermeline, UK).  ResultsOn the densely sampled 3D and en-face images, hard exsudates, peripheral laser spots as well as proliferative neovascularization were readily detected. Characteristic structural changes resulting from laser burns could easily be visualized across the whole field of view in the OCT datasets. In addition, depth-scans and B-scans allowed to identify additional structural changes including IS/OS disruption, RPE detachment or neovascularisation reaching into the vitreous across the field of view.  ConclusionsThree dimensional visualization of the retina over 60° field of view with a MHz OCT is feasible in patients with diabetic retinopathy. It might allow additional clinical insights in peripheral changes such as laser spots or retinal neovascularisation. 3D reconstruction of OCT dataset of patient with diabetic retinopathy with neovascularization (green), hard exsudates (yellow), epiretinal membrane and peripheral retinal scars after panretinal laser treatment (blue). Indications with arrows are examplatory. Top: En-face of same patient as in figure 1. Red line indicates the position of B-Frame below. Retinal scars due to focal laser coagulation temporal of the fovea visible. Bottom: Neovascularisation (green) reaching into the vitreous is visible on the left side. Retinal scars especially on RPE level due to panretinal laser treatment (blue) are observable.},
       ISSN = {1552-5783},
       url = {http://dx.doi.org/},
       year = {2014},
    keywords = {AG-Huber_OCT},
       type = {Journal Article}
    }
    
  • Kortuem, Karsten Ulrich and Kolb, Jan Philip and Klein, Thomas and Mohler, Kathrin and Kampik, Anselm and Neubauer, Aljoscha S. and Wieser, Wolfgang and Huber, Robert and Haritoglou, Christos: Wide Field MHz OCT imaging of the vitreoretinal interface. Investigative Ophthalmology & Visual Science, no. 55, pp. 1619-1619, 2014
    BibTeX Link
    @article{Kortuem2014,
       author = {Kortuem, Karsten Ulrich and Kolb, Jan Philip and Klein, Thomas and Mohler, Kathrin and Kampik, Anselm and Neubauer, Aljoscha S. and Wieser, Wolfgang and Huber, Robert and Haritoglou, Christos},
       title = {Wide Field MHz OCT imaging of the vitreoretinal interface},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {55},
       number = {13},
       pages = {1619-1619},
       abstract = { PurposeTo investigate changes caused by vitreoretinal interface disease with a multi-MHz OCT over a wide field of view of 60°.  MethodsWe used custom swept-source OCT device with a 1060nm Fourier-domain mode-locked laser source achieving a line rate of 1.68MHz. Within 1.82s datasets consisting of 2088x1024 A-scans over 60° were acquired from 5 patients with vitreoretinal traction due to VMTS and 3 patients with vascular pathology. The densely sampled three dimensional datasets were investigated in B-Scan cross-sections as well as en-face images and 3D reconstructions.  ResultsVitreoretinal traction could be imaged well in most of the cases, although the current sensitivity of the system limited image quality. Across the whole 60° field of view in the OCT datasets vitreoretinal tractions could be topographically assessed, always including the macula and optic disc, where vitreous anchorage could be shown. By means of the depth-scans as part of the 3D OCT volume we could image traction-associated retinal changes such as retinal elevation or RPE detachment.  ConclusionsThis unique three dimensional visualization of the retina over 60° field of view with a MHz OCT is feasible in patients with vitreoretinal interface disease and might offer additional clinical insights on the three-dimensional topology of tractional changes. Three dimensional Wide Field MHz OCT retinal and vitreous visualization.},
       ISSN = {1552-5783},
       url = {http://dx.doi.org/},
       year = {2014},
    keywords = {AG-Huber_OCT},
       type = {Journal Article}
    }
    
  • Klein, Thomas and Draxinger, Wolfgang and Mohler, Kathrin and Kolb, Jan Philip and Wieser, Wolfgang and Kampik, Anselm and Neubauer, Aljoscha S. and Wolf, Armin and Huber, Robert: Wide-field choroidal thickness and en-face maps of patients created with MHz-OCT. Investigative Ophthalmology & Visual Science, no. 55, pp. 1620-1620, 2014
    BibTeX Link
    @article{Klein2014,
       author = {Klein, Thomas and Draxinger, Wolfgang and Mohler, Kathrin and Kolb, Jan Philip and Wieser, Wolfgang and Kampik, Anselm and Neubauer, Aljoscha S. and Wolf, Armin and Huber, Robert},
       title = {Wide-field choroidal thickness and en-face maps of patients created with MHz-OCT},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {55},
       number = {13},
       pages = {1620-1620},
       abstract = { PurposeTo study the feasibility of simultaneous peripheral and central choroidal thickness measurement and en-face visualization in patients with a variety of diseases, using a single high-resolution wide-field MHz-OCT dataset spanning more than 50 degrees field of view.  MethodsIn this retrospective study, choroidal morphology of 29 patients imaged with MHz-OCT was assessed. MHz-OCT is a custom SS-OCT operating at 1060nm and an axial line rate of 1.68MHz. The high speed, more than 30 times faster than current commercial devices, enabled a very high resolution scan protocol of 2088x1024 A-scans over a wide field of ~60 degrees. However, due to the very high speed, signal strength is lower compared to slower devices. Hence, thickness and structure maps were only created for selected datasets: The positions of Bruch’s membrane and choroid sclera junction were determined manually by a trained observer a subset of all A-scans, from which thickness and intensity maps were created.  ResultsDespite relative low signal strength, the choroid sclera junction could be clearly observed over the entire unshadowed image area in 15 of 29 patients. Apart from shadowing, visibility of this junction shows strong variation even within a single dataset due to varying retinal thickness, eye-blinks, saccades and retinal curvature. Thus, thickness could be evaluated at least in some areas for all 29 patients, especially in the periphery. Moreover, choroidal thickness varied considerably intra- and interindividually. In two patients, abrupt changes of the choroid were observed in the temporal periphery, which may resemble morphology or imaging artifact. In addition to thickness, en-face choroidal structure maps were extracted from the segmented OCT datasets. Visibility of choroidal vasculature in these maps correlates with choroidal thickness.  ConclusionsChoroidal thickness and structure in patients could be visualized over large areas for the first time. Due to focal choroidal thickness changes with large thickness gradients, high-density scan protocols may be favorable for OCT-based investigations of the choroid. En-face images of the choroid can be extracted from these high-resolution datasets, but the influence of choroidal thickness on the image information should be taken into account. Choroidal en-face image (top), color-coded thickness map with superimposed structural image (middle) and OCT B-frame (bottom) for two eyes (A,B).},
       ISSN = {1552-5783},
       url = {http://dx.doi.org/},
       year = {2014},
    keywords = {AG-Huber_OCT},
       type = {Journal Article}
    }