@inproceedings{Koch-2004,
   author = {Koch, Peter and Huettmann, Gereon and Schleiermacher, Hansfrieder and Eicholz, Joerg and Koch, Edmund},
   title = {Linear OCT system with down conversion of the fringe pattern},
   editor = {Valery, V. Tuchin and Joseph, A. Izatt and James, G. Fujimoto},
   publisher = {SPIE},
   volume = {5316},
   pages = {260-267},
Year = { 2004},
URL = { https://doi.org/10.1117/12.531323}

}

@inproceedings{Hüttmann2003,
   author = {Huettmann, Gereon and Radt, Benno and Serbin, Jesper and Birngruber, Reginald},
   title = {Inactivation of proteins by irradiation of gold nanoparticles with nano- and picosecond laser pulses},
   editor = {Rudolf, W. Steiner},
   publisher = {SPIE},
   volume = {5142},
   pages = {88-95},
URL = { https://doi.org/10.1364/ECBO.2003.5142_88},
year = { 2003}
}

@inproceedings{Schuele-2002,
   author = {Schuele, Georg and Huettmann, Gereon and Brinkmann, Ralf},
   title = {Noninvasive temperature measurements during laser irradiation of the retina with optoacoustic techniques},
   editor = {Fabrice, Manns and Per, G. Soederberg and Arthur, Ho},
   publisher = {Proc. SPIE},
   volume = {4611},
   pages = {64-71},
year = { 2002},
url = { https://doi.org/10.1117/12.470601} 
}

@inproceedings{Lange2001,
   author = {Lange, Bjoern I. and Radt, Benno and Huettmann, Gereon},
   title = {Cr,Tm,Ho: YAG laser amplifier},
   editor = {Richard, Scheps},
   publisher = {SPIE},
   volume = {4267},
   pages = {169-174},
URL = {https://doi.org/10.1117/12.424616},
Year = { 2001}
}

@inproceedings{Radt-2001,
   author = {Radt, Benno and Serbin, Jesper and Lange, Bjoern I. and Birngruber, Reginald and Huettmann, Gereon},
   title = {Laser-generated micro- and nanoeffects: inactivation of proteins coupled to gold nanoparticles with nano- and picosecond pulses},
   editor = {Reginald, Birngruber and Hubert van den, Bergh},
   publisher = {SPIE},
   volume = {4433},
   pages = {16-24},
year = { 2001},
URL = { https://doi.org/10.1117/12.446518}

}

@article{Hüttmann,
   author = {Hüttmann, G. and Serbin, J. and Radt, B. and Lange, Björn I. and Birngruber, R.},
   title = {Model system for investigating laser-induced subcellular microeffects.},
   journal = {Proc SPIE},
   volume = {4257},
   pages = {398-409},
   year = {2001}
}

@article{Brinkmann2000-1,
   author = {Brinkmann, R. and Huttmann, G. and Rogener, J. and Roider, J. and Birngruber, R. and Lin, C. P.},
   title = {Origin of retinal pigment epithelium cell damage by pulsed laser irradiance in the nanosecond to microsecond time regimen},
   journal = {Lasers Surg Med},
   volume = {27(5)},
   Year = { 2000},
url = { https://www.researchgate.net/publication/227934019_Origin_of_retinal_pigment_epithelium_cell_damage_by_pulsed_laser_irradiance_in_the_nanosecond_to_microsecond_time_regimen},
   pages = {451-64},
   note = {0196-8092 (Print)
In Vitro
Journal Article
Research Support, Non-U.S. Gov't},
   abstract = {BACKGROUND AND OBJECTIVE: Selective photodamage of the retinal pigment epithelium (RPE) is a new technique to treat a variety of retinal diseases without causing adverse effects to surrounding tissues such as the neural retina including the photoreceptors and the choroid. In this study, the mechanism of cell damage after laser irradiation was investigated. STUDY DESIGN/MATERIALS AND METHODS: Single porcine RPE-melanosomes and RPE cells were irradiated with a Nd:YLF laser (wavelength lambda = 527 nm, adjustable pulse duration tau = 250 nsec-3 microsec) and a Nd:YAG laser (lambda = 532 nm, tau = 8 nsec). Fast flash photography was applied to observe vaporization at melanosomes in suspension. A fluorescence viability assay was used to probe the cells vitality. RESULTS: The threshold radiant exposures for vaporization around individual melanosomes and for ED50 cell damage are similar at 8-nsec pulse duration. Both thresholds increase with pulse duration; however, the ED50 cell damage radiant exposure is 40% lower at 3 microsec. Temperature calculations to model the onset of vaporization around the melanosomes are in good agreement with the experimental results when assuming a surface temperature of 150 degrees C to initiate vaporization and a homogeneous melanosome absorption coefficient of 8,000 cm(-1). Increasing the number of pulses delivered to RPE cells at a repetition rate of 500 Hz, the ED50 value }
}

@article{Hüttmann,
   author = {Hüttmann, G. and Radt, B. and Birngruber, R.},
   title = {Laserinduzierte Mikro- und Nanoeffekte - Von der selektiven Thermolyse zu molekularen Nanoeffekten},
   journal = {LaserOpto},
   volume = {32},
   pages = {47-55},
   year = {2000}
}

@article{Hüttmann,
   author = {Hüttmann, G. and Birngruber, R.},
   title = {Laserinduzierte thermische Gewebseffekte mit mikroskopischer und makromolekularer Präzision},
   journal = {Z Med Phys},
   volume = {10},
   pages = {169-174},
   year = {2000}
}

@article{Schüle,
   author = {Schüle, G. and Hüttmann, G. and Roider, J. and Wirbelauer, C. and Birngruber, R. and Brinkmann, R.},
   title = {Optoacoustic measurements during µs-irradiation of the retinal pigment epithelium},
   journal = {Proc. SPIE},
   volume = {3914A},
   year = {2000}
}

@article{Hüttmann1999,
   author = {Huttmann, G. and Birngruber, R.},
   title = {On the possibility of high-precision photothermal microeffects and the measurement of fast thermal denaturation of proteins},
   journal = {Ieee Journal of Selected Topics in Quantum Electronics},
   volume = {5},
   number = {4},
   pages = {954-962},
   note = {248CM
Times Cited:77
Cited References Count:43},
   abstract = {The precision of laser-induced effects is often limited by thermal and thermomechanical collateral damage. Adjusting the pulsewidth of the laser to the size of the absorbing structure can at least avoid thermal side effects and facilitates a selective treatment of vessels or pigmented cells. Further extending the precision of thermal effects below cellular dimensions by using nanometer sized particles could open up new fields of applications for lasers in medicine and biology. Calculations show that under irradiation with nano- or picosecond laser pulses gold particles of submicrometer size can easily be heated by several hundred K, High temperatures have to be used for subcellular thermal effects, because heat confinement to such small structures requires the thermal damage to occur in extremely short times. Estimating the denaturation temperature by extrapolating the Arrhenius equation from a time range of minutes and seconds into a time range of nano- and picoseconds leads to temperatures beta;een 370 K-470 K, There is evidence that in aqueous media, due to the surface tension, these temperatures can be generated at the surface of nanometer sized particles without vaporization of the surrounding water,
In order to show whether or not an extrapolation of the damage rates over six to nine orders of magnitude gives correct data, a temperature-jump experiment was designed and tested which allows to measure denaturation rates of proteins in the millisecond time range. Denaturation of chymotrypsin was observed within 300 mu s at temperatures below 380 K, The rate constants for the unfolding of chymotrypsin followed the Arrhenius equation up to rates of 3000 s(-1).},
   keywords = {laser medicine
microeffects
protein denaturation
thermal effects
assisted laser inactivation},
   ISSN = {1077-260X},
   DOI = {Doi 10.1109/2944.796317},
   url = {<Go to ISI>://WOS:000083257800013},
   year = {1999},
   type = {Journal Article}
}

@article{Hüttmann,
   author = {Hüttmann, G. and Birngruber, R.},
   title = {On the Possibility of High-Precision Photothermal Microeffects and the Measurement of Fast thermal Denaturation of Proteins.},
   journal = {IEEE J Quant Electr},
   volume = {5},
   number = {4},
   pages = {954-962},
   year = {1999}
}

@article{Brinkmann1999,
   author = {Brinkmann, R. and Rögener, J. and Lin, C.P. and Roider, J. and Birngruber, R. and Hüttmann, G.},
   title = {Selective RPE-Photodestruction: Mechanism of Cell Damage by pulsed laser irradiance in the ns to µs time regime},
   journal = {Proc. SPIE},
   volume = {3601},
   pages = {59-65},
   year = { 1999}
}

@article{Hüttmann1998,
   author = {Hüttmann, G. and Birngruber, R.},
   title = {Dynamics of Thermal Microeffects: Rate Constants of Thermal Denaturation Measured by a Temperature-Jump Experiment},
   journal = {OSA TOPS},
   volume = {22},
   pages = {300-305},
   year = {1998},
   type = {Journal Article}
}

@article{Eichenauer,
   author = {Eichenauer, Rolf H. and Huettmann, Gereon and Woermer, Stephan and Koop, Norbert and Beyer, Wolfgang and Jocham, Dieter},
   title = {New balloon catheter system used for PDT in the human urinary bladder: accuracy of light distribution},
   pages = {138-144},
   note = {10.1117/12.308141},
   abstract = {Photodynamic therapy (PDT) may provide a new approach for treatment of patients with superficial transitional carcinoma and carcinoma in situ of the bladder. The light applicator for the bladder wall (Rusch) is constructed as a balloon catheter with two concentric balloons. A new PDT applicator (Rusch) was assessed for the homogeneity and accuracy of irradiation during PDT. In an in-vitro experiment with 17 freshly harvested porcine bladders the fluence rate was measured locally with isotropic detectors. The results were compared to the light fluence detected by the PDT applicator. The increase of the fluence rate (beta) inside the bladders due to back scattering ranged between 5.3 and 7.0 with an average of 6.2. Local variations of the fluence rate in the spherical bladders were also smaller than 15%. Therefore it is concluded, that a homogeneous and accurate irradiation during PDT is possible. Blood between the outer balloon and the bladder wall reduces the local fluence rate strongly and should to be avoided. Also larger air bubbles in the applicator can lead to an inhomogeneous light distribution. In regular application the presented new catheter system provides accurate and easy light dosimetry during PDT of the bladder. Attention had to be paid to a continuous flushing of the space between balloon and bladder wall in order to prevent the accumulation of urine and blood. To avoid a malfunction of the system and large errors in light dosimetry and application, it is advisable to monitor the measured light dosage and the shape of the balloon using ultrasonography during PDT.},
   year = {1998}
}

@article{Hendrich,
   author = {Hendrich, C. and Hüttmann, G. and Lehnert, C. and Diddens, H. and Siebert, W.E.},
   title = {Photodynamic laser therapy for rheumatoid arthritis: Cell culture studies and animal experiments.},
   journal = {Knee Surg Sports Traumatol Arthroscopy},
   volume = {5},
   pages = {58-63},
   year = {1997}
}

@article{Novo,
   author = {Novo, M. and Hüttmann, G. and Diddens, H.},
   title = {Chemical instability of 5-aminolevulinic acid used in the fluorescence diagnosis of bladder tumours},
   journal = {J Photoch Photobio},
   volume = {34},
   pages = {143-148},
   year = {1996}
}

@inproceedings{Hüttmann,
   author = {Hüttmann, G. and Achtelik, W. and Löning, M. and Sommer, K. and Diddens, H.},
   title = {Fluorescence microscopy studies on ALA sensitized tissues},
   booktitle = {SPIE Proc.},
   volume = {2926},
   pages = {24-31},
year = { 1996},
URL = {  https://doi.org/10.1117/12.260815}

}

@inproceedings{Hüttmann1,
   author = {Hüttmann, G. and Hendrich, C. and Birngruber, R. and Lehnert, C. and Seara, J. and Siebert, W. E. and Diddens, H.},
   title = {Protoporphyrin IX distribution after intra-articular and systemic application of 5-aminolevulinic acid in healthy and arthritic joints . 
Mechanisms and Techniques in Photodynamic Therapy V,},
   booktitle = {Proc. SPIE},
   volume = {2675},
   pages = {238-242},
Year = { 1996}

}

@inproceedings{Pan,
   author = {Pan, Y. and Engelhardt, R. and Rosperich, J. and Hüttmann, G. and Birngruber, R.},
   title = {Measurement of Optical-Transport-Coefficients of Intralipid in Visible and NIR Range},
   booktitle = {Proc. SPIE},
   volume = {2134A},
   pages = {354-363},
Year = { 1994},
URL = { https://doi.org/10.1117/12.182954}

}

@inproceedings{Hüttmann,
   author = {Hüttmann, G. and Churio, S. and Braslavsky, S.E. and Birngruber, R.},
   title = {The Possibility of Measuring Thermal Protein Denaturation by an Optoacoustic Method.},
   booktitle = {Proc. SPIE},
   volume = {2077},
   pages = {202-212},
url = { https://doi.org/10.1117/12.168030},
year = { 1994}

}