H. Hoerauf, C. Scholz, P. Koch, R. Engelhardt, and H. Laqua,
Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye, Arch Ophthalmol , vol. 120, no. 6, pp. 816-9, 2002.
Datei: query.fcgi
Bibtex: BibTeX
@article{Hoerauf2002,
   author = {Hoerauf, H. and Scholz, C. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.},
   title = {Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye},
   journal = {Arch Ophthalmol},
   volume = {120},
   number = {6},
   pages = {816-9},
   note = {0003-9950 (Print)
Journal Article},
   abstract = {OBJECTIVE: To present a new imaging method for the anterior segment of the eye. METHODS: Transscleral optical coherence tomographic images were generated in healthy volunteers using a slitlamp-adapted prototype equipped with a superluminescence diode with an infrared wavelength of 1310 nm. RESULTS: The optical coherence tomographic system used allowed penetration of human sclera in vivo and high-resolution, cross-sectional imaging of the anterior chamber angle and the ciliary body. CONCLUSION: The 1310-nm optical coherence tomographic image shows a significant potential as a noninvasive diagnostic tool for the anterior segment of the eye.},
   keywords = {Anatomy, Cross-Sectional/*methods
Anterior Eye Segment/*anatomy & histology
*Diagnostic Techniques, Ophthalmological
Humans
Interferometry
Light
Sclera
Tomography/methods},
   url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12049589},
   year = { 2002},
   type = {Journal Article}
}
H. Hoerauf, J. Winkler, C. Scholz, C. Wirbelauer, R. S. Gordes, P. Koch, R. Engelhardt, and H. Laqua,
Transscleral optical coherence tomography--an experimental study in ex-vivo human eyes, Lasers Surg Med , vol. 30, no. 3, pp. 209-15, 2002.
Datei: query.fcgi
Bibtex: BibTeX
@article{Hoerauf2002,
   author = {Hoerauf, H. and Winkler, J. and Scholz, C. and Wirbelauer, C. and Gordes, R. S. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.},
   title = {Transscleral optical coherence tomography--an experimental study in ex-vivo human eyes},
   journal = {Lasers Surg Med},
   volume = {30},
   number = {3},
   pages = {209-15},
   note = {0196-8092 (Print)
Journal Article},
   abstract = {BACKGROUND AND OBJECTIVE: To evaluate the potentials of a 1310-nm optical coherence tomography (OCT) system to penetrate the highly backscattering sclera in enucleated human eyes and provide visualization of intraocular structures by transscleral imaging. STUDY DESIGN/MATERIALS AND METHODS: OCT-images were generated by an experimental prototype (Medical Laser Center, Lubeck, Germany) using a superluminescence diode with a wavelength of 1310 nm. OCT-images were taken from two enucleated human eyes using 100-200 axial scans with 60 Hz line scan frequency and compared to subsequent histologic sections. RESULTS: Transscleral OCT allowed penetration of the sclera and the anterior chamber angle could be completely identified. Some change within the anterior eye segment could be demonstrated with high accuracy. Additionally, limited demonstration of the ciliary body region was achieved. Due to limited signal intensity no detailed imaging of the pars plana and pars plicata region was possible. However, more posterior measurements allowed transscleral visualization of a retinal detachment. CONCLUSIONS: OCT using lightsources with a wavelength longer than that used in conventional OCT provides a promising imaging technique at high resolution allowing transscleral imaging of the anterior eye segment.},
   keywords = {Anterior Chamber/cytology
Anterior Eye Segment/cytology
Ciliary Body/cytology
Equipment Design
Eye/*cytology
Humans
Tomography/instrumentation/*methods},
   url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11891740},
   year = {2002},
   type = {Journal Article}
}
C. Wirbelauer, C. Scholz, H. Hoerauf, G. O. Bastian, R. Engelhardt, and H. Laqua,
Examination of the cornea using optical coherence tomography, Ophthalmologe , vol. 98, no. 2, pp. 151-156, 2001.
DOI:DOI 10.1007/s003470170176
Datei: WOS:000167041400005
Bibtex: BibTeX
@article{Wirbelauer2001,
   author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Bastian, G. O. and Engelhardt, R. and Birngruber, R. and Laqua, H.},
   title = {Examination of the cornea using optical coherence tomography},
   journal = {Ophthalmologe},
   volume = {98},
   number = {2},
   pages = {151-156},
   note = {403KQ
Times Cited:34
Cited References Count:18},
   abstract = {Introduction. This study evaluated the clinical use of optical coherence tomography (OCT) for two-dimensional representation of the cornea.
Patients and methods. Noncontact slit-lamp-adapted OCT was used in selected cases to evaluate pathologically altered corneas and to measure the central corneal thickness and curvature.
Results. OCT provided correlation between differences in reflection and morphological changes. Scar tissue resulted in hyperreflective light scattering, wheras cystic lesions were hyporeflective. Precise biomorphometry also allowed representation of intrastromal and retrocorneal changes. Central corneal thickness measured by OCT yielded reproducible values and corn be calculated from the optical signals of the corneal surface.
Conclusions. OCT provides high-resolution representation of the cornea and exact evaluation of its morphology, thickness, and curvature. Due to the noncontact, simple,and rapid examination using the slitlamp the corneal OCT method is a promising additional diagnostic modality.},
   keywords = {optical coherence tomography
cornea
pachymetry
profilometry
thickness measurements
in-vivo
pachymetry
topography
eye},
   ISSN = {0941-293X},
   DOI = {DOI 10.1007/s003470170176},
   url = {<Go to ISI>://WOS:000167041400005},
   year = {2001},
   type = {Journal Article}
}
C. Wirbelauer, C. Scholz, H. Hoerauf, G. O. Bastian, R. Engelhardt, and H. Laqua,
Untersuchungen der Hornhaut mittels optischer Kohärenztomographie., Ophthalmologe , vol. 98, pp. 151-156, 2001.
Bibtex: BibTeX
@article{Wirbelauer2001,
   author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Bastian, G. O. and Engelhardt, R. and Birngruber, R. and Laqua, H.},
   title = {Untersuchungen der Hornhaut mittels optischer Kohärenztomographie.},
   journal = {Ophthalmologe},
   volume = {98},
   pages = {151-156},
   year = {2001},
   type = {Journal Article}
}
H. Hoerauf, R. Gordes, C. Scholz, P. Koch, R. Engelhardt, C. Wirbelauer, and H. Laqua,
First experimental and clinical results of transscleral OCT, Investigative Ophthalmology & Visual Science , vol. 41, no. 4, pp. S786-S786, 2000.
Datei: WOS:000086246704240
Bibtex: BibTeX
@article{Hoerauf2000,
   author = {Hoerauf, H. and Gordes, R. and Scholz, C. and Koch, P. and Engelhardt, R. and Wirbelauer, C. and Laqua, H. and Birngruber, R.},
   title = {First experimental and clinical results of transscleral OCT},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {41},
   number = {4},
   pages = {S786-S786},
   note = {Suppl. S
300HF
4171B118
Times Cited:0
Cited References Count:0},
   ISSN = {0146-0404},
   url = {<Go to ISI>://WOS:000086246704240},
   year = {2000},
   type = {Journal Article}
}
H. Hoerauf, C. Wirbelauer, C. Scholz, R. Engelhardt, P. Koch, and H. Laqua,
Slit-lamp-adapted optical coherence tomography of the anterior segment, Graefes Archive for Clinical and Experimental Ophthalmology , vol. 238, no. 1, pp. 8-18, 2000.
DOI:DOI 10.1007/s004170050002
Datei: WOS:000085205300002
Bibtex: BibTeX
@article{Hoerauf2000,
   author = {Hoerauf, H. and Wirbelauer, C. and Scholz, C. and Engelhardt, R. and Koch, P. and Laqua, H. and Birngruber, R.},
   title = {Slit-lamp-adapted optical coherence tomography of the anterior segment},
   journal = {Graefes Archive for Clinical and Experimental Ophthalmology},
   volume = {238},
   number = {1},
   pages = {8-18},
   note = {282FC
Times Cited:77
Cited References Count:19},
   abstract = {Purpose: To evaluate the diagnostic potential of a slit-lamp-adapted optical coherence tomography (OCT) system as an in vivo imaging device for routine clinical examination of the anterior segment of the eve.
Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a slit-lamp-adapted OCT system using 100-200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue.
Results: The slit-lamp-adapted OCT system allowed direct biomicroscopic imaging of the measured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epithelium could be visualized with high accuracy, Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possible. Complete demonstration of the chamber angle was difficult clue to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris.
Conclusions: Slit-lamp-adapted OCT is a diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular structures.},
   keywords = {in-vivo
nerve
eye},
   ISSN = {0721-832X},
   DOI = {DOI 10.1007/s004170050002},
   url = {<Go to ISI>://WOS:000085205300002},
   year = {2000},
   type = {Journal Article}
}
H. Hoerauf, R. S. Gordes, C. Scholz, C. Wirbelauer, P. Koch, R. Engelhardt, J. Winkler, and H. Laqua,
First experimental and clinical results with transscleral optical coherence tomography, Ophthalmic Surg Lasers , vol. 31, no. 3, pp. 218-22, 2000.
Bibtex: BibTeX
@article{Hoerauf,
   author = {Hoerauf, H. and Gordes, R. S. and Scholz, C. and Wirbelauer, C. and Koch, P. and Engelhardt, R. and Winkler, J. and Laqua, H. and Birngruber, R.},
   title = {First experimental and clinical results with transscleral optical coherence tomography},
   journal = {Ophthalmic Surg Lasers},
   volume = {31},
   number = {3},
   pages = {218-22},
   note = {Hoerauf, H
Gordes, R S
Scholz, C
Wirbelauer, C
Koch, P
Engelhardt, R
Winkler, J
Laqua, H
Birngruber, R
Comparative Study
United states
Ophthalmic Surg Lasers. 2000 May-Jun;31(3):218-22.},
   abstract = {BACKGROUND AND OBJECTIVE: To evaluate the potentials of optical coherence tomagraphy (OCT) using long wavelength to penetrate highly scattering tissues of the eye and visualize the anterior chamber angle and the ciliary body. METHODS: OCT images were generated by an experimental prototype in enucleated porcine eyes using as light source a superluminiscent diode with a wavelength of 1310 nm and a scan frequency of 60 Hz. The number of lateral scans was variable in a range from 100 to 400. RESULTS: Infrared OCT was able to penetrate the sclera. The anterior chamber angle could be visualized completely and the ciliary body could be identified. However, it was not possible to penetrate the highly reflective iris pigment epithelium. CONCLUSION: The use of infrared OCT allows penetration of the sclera, thus, providing complete visualization of the anterior chamber angle and limited demonstration of the ciliary body. Because of its higher resolution, it may represent an interesting noninvasive alternative to ultrasound biomicroscopy.},
   keywords = {Animals
Anterior Chamber/ anatomy & histology
Ciliary Body/ anatomy & histology
Diagnostic Techniques, Ophthalmological
Humans
Interferometry
Iris/ anatomy & histology
Light
Pigment Epithelium of Eye/cytology
Reference Values
Sclera
Swine
Tomography/ methods},
   year = { 2000}
}
C. Wirbelauer, C. Scholz, H. Hoerauf, R. Engelhardt, and H. Laqua,
Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy, Am J Ophthalmol , vol. 130, no. 6, pp. 693-9, 2000.
Datei: S0002939400006024
Bibtex: BibTeX
@article{Wirbelauer,
   author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Engelhardt, R. and Birngruber, R. and Laqua, H.},
   title = {Corneal optical coherence tomography before and immediately after excimer laser photorefractive keratectomy},
   journal = {Am J Ophthalmol},
   volume = {130},
   number = {6},
   pages = {693-9},
year ={ 2000},
url = { https://www.sciencedirect.com/science/article/abs/pii/S0002939400006024},
   note = {0002-9394 (Print)
Journal Article},
   abstract = {PURPOSE: To investigate the representation of the corneal structure with optical coherence tomography before and immediately after excimer laser photorefractive keratectomy. METHODS: Twenty-four eyes of 24 patients with myopia and myopic astigmatism were prospectively studied. The corneal thickness and the corneal profile were assessed with slit-lamp-adapted optical coherence tomography preoperatively and immediately after excimer laser photorefractive keratectomy. RESULTS: The attempted mean spherical equivalent of the refractive corrections was -6.7 +/- 3.6 (mean +/- SD) diopters with a mean calculated stromal ablation depth of 91 +/- 38 microm. The corneal optical coherence tomography was reproducible in all patients, demonstrating a mean decrease of central corneal thickness after epithelial debridement and excimer laser photorefractive keratectomy of 118 +/- 45 microm. The comparison of the calculated stromal ablation depth and the corneal thickness changes determined by corneal optical coherence tomography revealed a significant linear relationship with a correlation coefficient of 0.88 (P <.001). The flattening of the corneal curvature was confirmed in all patients with the optical coherence tomography system and correlated with the attempted refractive correction (r =.82, P <.001). CONCLUSIONS: The slit-lamp-adapted optical coherence tomography system presented in this study allowed noncontact, cross-sectional, and high-resolution imaging of the corneal configuration. This initial clinical evaluation demonstrated that corneal optical coherence tomography could be a promising diagnostic modality to monitor corneal changes of thickness and curvature before and after excimer laser photorefractive keratectomy.},
   keywords = {Adult
Astigmatism/*diagnosis/surgery
Cornea/*pathology/surgery
*Diagnostic Techniques, Ophthalmological
Female
Humans
Interferometry
*Keratectomy, Photorefractive, Excimer Laser
Male
Middle Aged
Myopia/*diagnosis/surgery
Prospective Studies
Refraction, Ocular
Reproducibility of Results
Sound
}
}
J. Welzel, E. Lankenau, and R. Engelhardt,
Optical coherence tomography of the skin, Curr Probl Dermatol , vol. 26, pp. 27-37, 1998.
Datei: query.fcgi
Bibtex: BibTeX
@article{Welzel1998,
   author = {Welzel, J. and Lankenau, E. and Birngruber, R. and Engelhardt, R.},
   title = {Optical coherence tomography of the skin},
   journal = {Curr Probl Dermatol},
   volume = {26},
   pages = {27-37},
   note = {1421-5721 (Print)
Journal Article
Research Support, Non-U.S. Gov't},
   keywords = {Biomedical Engineering
Blister/pathology
Eczema/pathology
Epidermis/anatomy & histology/pathology
Humans
Melanoma/pathology
Optics
Pemphigus/pathology
Scabies/parasitology/pathology
Skin/*anatomy & histology/pathology
Skin Neoplasms/pathology
Tomography/*methods},
   url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9597313},
   year = {1998},
   type = {Journal Article}
}
Norbert Koop, Ralf Brinkmann, Eva Lankenau, Stefan Flache, and Ralf Engelhardt,
Optische Kohärenztomographie der Kornea und des vorderen Augenabschnitts, Der Ophthalmologe , vol. 94, no. 7, pp. 481-486, 1997.
Datei: s003470050143
Bibtex: BibTeX
@article{Koop1997,
   author = {Koop, Norbert and Brinkmann, Ralf and Lankenau, Eva and Flache, Stefan and Engelhardt, Ralf and Birngruber, Reginald},
   title = {Optische Kohärenztomographie der Kornea und des vorderen Augenabschnitts},
   journal = {Der Ophthalmologe},
   volume = {94},
   number = {7},
   pages = {481-486},
   ISSN = {1433-0423},
   url = {http://dx.doi.org/10.1007/s003470050143},
   year = {1997},
   type = {Journal Article}
}
J. Welzel, E. Lankenau, and R. Engelhardt,
Optical coherence tomography of the human skin, J Am Acad Dermatol , vol. 37, no. 6, pp. 958-63, 1997.
Datei: query.fcgi
Bibtex: BibTeX
@article{Welzel1997,
   author = {Welzel, J. and Lankenau, E. and Birngruber, R. and Engelhardt, R.},
   title = {Optical coherence tomography of the human skin},
   journal = {J Am Acad Dermatol},
   volume = {37},
   number = {6},
   pages = {958-63},
   note = {0190-9622 (Print)
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't},
   abstract = {BACKGROUND: Optical coherence tomography (OCT) is a new diagnostic method for tissue characterization. OBJECTIVE: We investigated normal and pathologic structures in human skin in several locations to evaluate the potential application of this technique to dermatology. METHODS: Based on the principle of low-coherence interferometry, cross-sectional images of the human skin can be obtained in vivo with a high spatial resolution of about 15 microns. Within a penetration depth of 0.5 to 1.5 mm, structures of the stratum corneum, the living epidermis, and the papillary dermis can be distinguished. RESULTS: Different layers could be detected that were differentiated by induction of experimental blisters and by comparison with corresponding histologic sections. Furthermore, OCT images of several skin diseases and tumors were obtained. CONCLUSION: OCT is a promising new imaging method for visualization of morphologic changes of superficial layers of the human skin. It may be useful for noninvasive diagnosis of bullous skin diseases, skin tumors, and in vivo investigation of pharmacologic effects.},
   keywords = {Adult
Anatomy, Cross-Sectional
Basement Membrane/pathology
Blister/diagnosis/pathology
Epidermis/anatomy & histology
Evaluation Studies
Female
Forearm/anatomy & histology
Hand/anatomy & histology
Humans
Hutchinson's Melanotic Freckle/diagnosis/pathology
Image Enhancement
Interferometry
Male
Melanoma/diagnosis/pathology
Nails/anatomy & histology
Optics
Skin/*anatomy & histology
Skin Diseases/*diagnosis/pathology
Skin Diseases, Vesiculobullous/diagnosis/pathology
Skin Neoplasms/diagnosis/pathology
Tomography/*methods},
   url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9418764},
   year = {1997},
   type = {Journal Article}
}
J. Welzel, E. Lankenau, and R. Engelhardt,
Optical coherence tomography of the human skin, J Am Acad Dermatol , vol. 37, no. 6, pp. 958-63, 1997.
Datei: query.fcgi
Bibtex: BibTeX
@article{Welzel1997,
   author = {Welzel, J. and Lankenau, E. and Birngruber, R. and Engelhardt, R.},
   title = {Optical coherence tomography of the human skin},
   journal = {J Am Acad Dermatol},
   volume = {37},
   number = {6},
   pages = {958-63},
   note = {0190-9622 (Print)
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't},
   abstract = {BACKGROUND: Optical coherence tomography (OCT) is a new diagnostic method for tissue characterization. OBJECTIVE: We investigated normal and pathologic structures in human skin in several locations to evaluate the potential application of this technique to dermatology. METHODS: Based on the principle of low-coherence interferometry, cross-sectional images of the human skin can be obtained in vivo with a high spatial resolution of about 15 microns. Within a penetration depth of 0.5 to 1.5 mm, structures of the stratum corneum, the living epidermis, and the papillary dermis can be distinguished. RESULTS: Different layers could be detected that were differentiated by induction of experimental blisters and by comparison with corresponding histologic sections. Furthermore, OCT images of several skin diseases and tumors were obtained. CONCLUSION: OCT is a promising new imaging method for visualization of morphologic changes of superficial layers of the human skin. It may be useful for noninvasive diagnosis of bullous skin diseases, skin tumors, and in vivo investigation of pharmacologic effects.},
   keywords = {Adult
Anatomy, Cross-Sectional
Basement Membrane/pathology
Blister/diagnosis/pathology
Epidermis/anatomy & histology
Evaluation Studies
Female
Forearm/anatomy & histology
Hand/anatomy & histology
Humans
Hutchinson's Melanotic Freckle/diagnosis/pathology
Image Enhancement
Interferometry
Male
Melanoma/diagnosis/pathology
Nails/anatomy & histology
Optics
Skin/*anatomy & histology
Skin Diseases/*diagnosis/pathology
Skin Diseases, Vesiculobullous/diagnosis/pathology
Skin Neoplasms/diagnosis/pathology
Tomography/*methods},
   url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9418764},
   year = {1997},
   type = {Journal Article}
}
N. Koop, E. Lankenau, S. Flache, and R. Engelhardt,
Optical coherence tomography of cornea and anterior segment of the eye, Ophthalmologe , vol. 94, no. 7, pp. 481-486, 1997.
DOI:DOI 10.1007/s003470050143
Datei: WOS:000071246700003
Bibtex: BibTeX
@article{Koop1997,
   author = {Koop, N. and Brinkmann, R. and Lankenau, E. and Flache, S. and Engelhardt, R. and Birngruber, R.},
   title = {Optical coherence tomography of cornea and anterior segment of the eye},
   journal = {Ophthalmologe},
   volume = {94},
   number = {7},
   pages = {481-486},
   note = {Yp140
Times Cited:34
Cited References Count:19},
   abstract = {Target: The method of optical coherence tomography (OCT) was investigated regarding its suitability and limits for measuring the cornea and the anterior segment of the eye. Furthermore, the stromal expansion of thermally induced lesions in the cornea directly after irradiation was determined within the scope of the laser thermokeratoplasty (LTK).
Material and methods: With the experimental scanning OCT system, x-z sections of the anterior eye segment were made with an optical resolution of about 20 mu m axially and 25 mu m laterally. Freshly enucleated, tonicized porcine eyes were used as model eyes. Thermal lesions were applied with a continuously emitting laser diode (lambda=1.86 mu m) and various radiation parameters, Before and after coagulation, the cornea was viewed from limbus to limbus in a central OCT scan and the individual coagulation source was measured,
Results: Global and local changes of the thickness of the cornea as well as the distance between cornea and lens were measured with high precision. Thermal lesions in their expansion can be clearly presented and matching well with the histologically stained sections, bur are not as exactly defined at the edges due to the limited optical resolution, as known from histological preparations.
Conclusion: With the OCT method quantitative measuring of the anterior eye segment can be performed in vitro and with reduced resolutions also in vivo. Due to the qualitatively good correspondence regarding the dimensions of thermal damage of the cornea with histologically obtained morphometric results,this method can be used for supervision of coagulation directly after LTK as well as for examination of the individual healing process.},
   keywords = {optical coherence tomography
pachometry
laser thermokeratoplasty
thermal damage
tissue},
   ISSN = {0941-293X},
   DOI = {DOI 10.1007/s003470050143},
   url = {<Go to ISI>://WOS:000071246700003},
   year = {1997},
   type = {Journal Article}
}
M. N. Asiyo-Vogel, N. Koop, R. Engelhardt, R. Eggers, and Alfred Vogel,
Evaluation of LTK lesions by optical low coherence tomography (OCT) and polarization microscopy after Sirius-Red staining, Ophthalmologe , vol. 94, no. 7, pp. 487-491, 1997.
DOI:DOI 10.1007/s003470050144
Datei: WOS:000071246700004
Bibtex: BibTeX
@article{Asiyo-Vogel1997,
   author = {Asiyo-Vogel, M. N. and Koop, N. and Brinkmann, R. and Engelhardt, R. and Eggers, R. and Birngruber, R. and Vogel, A.},
   title = {Evaluation of LTK lesions by optical low coherence tomography (OCT) and polarization microscopy after Sirius-Red staining},
   journal = {Ophthalmologe},
   volume = {94},
   number = {7},
   pages = {487-491},
   note = {Yp140
Times Cited:5
Cited References Count:21},
   abstract = {Background: Information on the extent and degree of the thermal effect produced is of great importance for control of the laser dosage in laser thermokeratoplasty (LTK) and for postoperative follow-up. We investigated on acute LTK effects which information images obtained by optical low coherence tomography (OCT) offer compared to those obtained by polarization microscopy.
Methods: Porcine eyes were irradiated through a 400 mu m quartz fiber using light from a laser diode emitting up to 300 mW at a wavelength of 1.86 mu m. Thermal lesions of varying strength were scanned using an experimental OCT device with about 25 mu m lateral and 20 mu m axial resolution. Histologic evaluation of the scanned areas was done by polarization microscopy after Sirius-Red staining, and similar lesions were also analyzed by TEM.
Results: Both methods differentiated three damage zones: a transition zone, a zone of moderate coagulation, and a central zone of strong coagulation. In the transition zone,increased birefringence was seen in polarization microscopy, which correlated with increased light scattering seen in the DCT images,ln the moderately coagulated zone, a decrease in birefringence was associated with an even stronger increase of the OCT signal, In the central zone,a loss of the fibrillar tissue structure was observed, which led to a complete loss of birefringence and a strong reduction of the OCT signal.
Conclusions: Although OCT does not provide the detailed information on thermal changes of tissue seen by the histologic method, it offers information on the extent and degree of tissue changes without preparation artifacts and provides a non-invasive method of immediate and follow-up control of LTK lesions, A quantitative analysis of changes in corneal thickness and curvature is much simpler than by a slit lamp. Time-resolved measurements of corneal light scattering may be used for on-line control of the laser-light dosage during LTK.},
   keywords = {refractive surgery
laser thermokeratoplasty
collagen denaturation
collagen shrinkage
optical low coherence tomography
polarization microscopy
sirius-red staining
tissue
collagen
eye},
   ISSN = {0941-293X},
   DOI = {DOI 10.1007/s003470050144},
   url = {<Go to ISI>://WOS:000071246700004},
   year = {1997},
   type = {Journal Article}
}
M Asiyo-Vogel, N Koop, R Engelhardt, R Eggers, and A Vogel,
Darstellung von LTK-Läsionen durch optische Kurzkohärenztomographie (OCT) und Polarisationsmikroskopie nach Sirius-Rot-Färbung, Ophthalmologe , vol. 94, pp. 487-491, 1997.
Bibtex: BibTeX
@article{Asiyo-Vogel1997,
   author = {Asiyo-Vogel, M and Koop, N and Brinkmann, R and Engelhardt, R and Eggers, R and Birngruber, R and Vogel, A},
   title = {Darstellung von LTK-Läsionen durch optische Kurzkohärenztomographie (OCT) und Polarisationsmikroskopie nach Sirius-Rot-Färbung},
   journal = {Ophthalmologe},
   volume = {94},
   pages = {487-491},
   year = {1997}
}
N. Koop, J. Kampmeier, A. Bruhns, M. AsiyoVogel, and R. Engelhardt,
Corneal collagen denaturation in laser thermokeratoplasty (LTK), Investigative Ophthalmology & Visual Science , vol. 38, no. 4, pp. 2514-2514, 1997.
Datei: WOS:A1997WN18602506
Bibtex: BibTeX
@article{Brinkmann1997,
   author = {Brinkmann, R. and Koop, N. and Kampmeier, J. and Bruhns, A. and AsiyoVogel, M. and Engelhardt, R. and Birngruber, R.},
   title = {Corneal collagen denaturation in laser thermokeratoplasty (LTK)},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {38},
   number = {4},
   pages = {2514-2514},
   note = {1
Wn186
Times Cited:0
Cited References Count:0},
   ISSN = {0146-0404},
   url = {<Go to ISI>://WOS:A1997WN18602506},
   year = {1997},
   type = {Journal Article}
}
Y. T. Pan, and R. Engelhardt,
Contrast limits of coherence-gated imaging in scattering media, Applied Optics , vol. 36, no. 13, pp. 2979-2983, 1997.
DOI:Doi 10.1364/Ao.36.002979
Datei: WOS:A1997WX24200038
Bibtex: BibTeX
@article{Pan1997,
   author = {Pan, Y. T. and Birngruber, R. and Engelhardt, R.},
   title = {Contrast limits of coherence-gated imaging in scattering media},
   journal = {Applied Optics},
   volume = {36},
   number = {13},
   pages = {2979-2983},
   note = {Wx242
Times Cited:50
Cited References Count:8},
   abstract = {The fundamental difference between time-resolved and coherence-gated imaging modalities in scattering media is analyzed in terms of their optical transfer functions. The effectiveness of coherence gating for multiple-scattering rejection is shown by imaging a 100-mu m-thick razor blade hidden in the scattering phantoms (i.e., Intralipid suspensions) with different scattering coefficients. We found that the imaging contrast is limited by multiple scattering and speckle effects in high-scattering media, and the measured effective penetration depth of optical coherence tomography is approximately equal to six mean free paths under the experimental conditions of a numerical aperture of less than 0.1 and a scattering anisotropy of approximately 0.8. (C) 1997 Optical Society of America.},
   keywords = {coherence-gated imaging
time-resolved imaging
low-coherence interference
imaging contrast limits
multiple scattering effects
tissue optics
tomography},
   ISSN = {0003-6935},
   DOI = {Doi 10.1364/Ao.36.002979},
   url = {<Go to ISI>://WOS:A1997WX24200038},
   year = {1997},
   type = {Journal Article}
}
M. Zwaan, U. Behnle, R. Engelhardt, Alfred Vogel, W. Kloess, and H. D. Weiss,
In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium., Fortschr Röntgenstr , vol. 164, no. 1, pp. 68-71, 1996.
Bibtex: BibTeX
@article{Zwaan,
   author = {Zwaan, M. and Behnle, U. and Engelhardt, R. and Vogel, A. and Kloess, W. and Birngruber, R. and Weiss, H. D.},
   title = {In-vitro-Untersuchungen zur gepulsten Laserangioplastie in flüssigem und gasförmigem Medium.},
   journal = {Fortschr Röntgenstr},
   volume = {164},
   number = {1},
   pages = {68-71},
   year = {1996}
}
Alfred Vogel, R. Engelhardt, U. Behnle, and U. Parlitz,
Minimization of cavitation effects in pulsed laser ablation illustrated on laser angioplasty, Appl Phys B , vol. 62, pp. 173-182, 1996.
Bibtex: BibTeX
@article{Vogel1996,
   author = {Vogel, A. and Engelhardt, R. and Behnle, U. and Parlitz, U.},
   title = {Minimization of cavitation effects in pulsed laser ablation illustrated on laser angioplasty},
   journal = {Appl Phys B},
   volume = {62},
   pages = {173-182},
   year = {1996}
}
Y. Pan, E. Lankenau, J. Welzel, and R. Engelhardt,
Optical Coherence - Gated imaging of Biological Tissues, IEEE J Quant Electr , vol. 2, no. 4, pp. 1029-1034, 1996.
Bibtex: BibTeX
@article{Pan,
   author = {Pan, Y. and Lankenau, E. and Welzel, J. and Birngruber, R. and Engelhardt, R.},
   title = {Optical Coherence - Gated imaging of Biological Tissues},
   journal = {IEEE J Quant Electr},
   volume = {2},
   number = {4},
   pages = {1029-1034},
   year = {1996}
}
N. Koop, M. N. AsiyoVogel, B. Kaftan, and R. Engelhardt,
CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy, Investigative Ophthalmology & Visual Science , vol. 37(3), pp. 305-305, 1996.
Datei: WOS:A1996TX39700305
Bibtex: BibTeX
@article{Brinkmann1996-2,
   author = {Brinkmann, R. and Koop, N. and AsiyoVogel, M. N. and Kaftan, B. and Birngruber, R. and Engelhardt, R.},
   title = {CW-IR laser thermokeratoplasty: Refractive changes and analysis by optical coherence tomography and light microscopy},
   journal = {Investigative Ophthalmology & Visual Science},
   volume = {37(3)},
   
   pages = {305-305},
   note = {Tx397
Times Cited:0
Cited References Count:0},
   ISSN = {0146-0404},
   url = {<Go to ISI>://WOS:A1996TX39700305},
   year = { 1996},
   type = {Journal Article}
}
Y. Pan, J. Rosperich, and R. Engelhardt,
Low-coherence optical tomography in turbid tissue: theoretical analysis., Appl Optics , vol. 34, no. 28, pp. 6564-6574, 1995.
Bibtex: BibTeX
@article{Pan,
   author = {Pan, Y. and Birngruber, R. and Rosperich, J. and Engelhardt, R.},
   title = {Low-coherence optical tomography in turbid tissue: theoretical analysis.},
   journal = {Appl Optics},
   volume = {34},
   number = {28},
   pages = {6564-6574},
   year = {1995}
}
Y. Pan, R. Engelhardt, and J. Rosperich,
Measurement of Optical-Transport-Coefficients of Intralipid in Visible and NIR Range, in Proc. SPIE , 1994. pp. 354-363.
Datei: 12.182954
Bibtex: BibTeX
@inproceedings{Pan,
   author = {Pan, Y. and Engelhardt, R. and Rosperich, J. and Hüttmann, G. and Birngruber, R.},
   title = {Measurement of Optical-Transport-Coefficients of Intralipid in Visible and NIR Range},
   booktitle = {Proc. SPIE},
   volume = {2134A},
   pages = {354-363},
Year = { 1994},
URL = { https://doi.org/10.1117/12.182954}

}
R Engelhardt, and W Meyer,
1. mu. s Alexandrit-Laser fuer laserinduzierte Schockwellenlithotripsie, Laser und Optoelektronik , vol. 21(6), pp. 56-61, 1989.
Bibtex: BibTeX
@article{Brinkmann1989,
   author = {Engelhardt, R;Brinkmann, R and Meyer, W},
   title = {1. mu. s Alexandrit-Laser fuer laserinduzierte Schockwellenlithotripsie},
   journal = {Laser und Optoelektronik},
   volume = {21(6)},
   pages = {56-61},
   year = {1989},
   type = {Journal Article}
}