2004 - 2003

2004

  • Ahlswede, W. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.: Three-dimensional imaging of photodynamic effects and spontaneous course in choroidal neovascularization. Ophthalmologe, no. 101, pp. 675-681, 2004
    BibTeX Link Link
    @article{Ahlswede2004,
       author = {Ahlswede, W. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.},
       title = {Three-dimensional imaging of photodynamic effects and spontaneous course in choroidal neovascularization},
       journal = {Ophthalmologe},
       volume = {101},
       number = {7},
       pages = {675-681},
       note = {842AB
    Times Cited:2
    Cited References Count:18},
       abstract = {Purpose. Photodynamic therapy (PDT) induces occlusive and regenerative effects in choroidal neovascularization (CNV) and physiological choroid. The process of vascular alteration is documented quantitatively and qualitatively by three-dimensional angiography.
    Method. In a prospective, randomized trial 30 patients with subfoveal CNV due to age-related macular degeneration (AMD) were treated with PDT or placebo. Fluorescence series with 32 tomographic images over a 4-mm depth were analyzed topographically and reproduced in a three-dimensional display.
    Results. At initial presentation CNV lesions were documented as a well-defined prominence in all patients, In the verteporfin group CNV height continuously decreased with each interval. In the placebo group CNV slightly increased in height during the first 6 months and remained stable at about 90% of the initial prominence at long-term follow-up. After 12 months 44% of the patients in the verteporfin group developed an additional choroidal defect.
    Conclusion. Three-dimensional angiography offers a reliable documentation of CNV progression and regression during PDT. A decrease in CNV size is associated with an increase in choroidal perfusion defects.},
       keywords = {photodynamic therapy
    age-related macular degeneration
    choroidal neovascularization
    three-dimensional topographic angiography
    green angiography
    human eyes
    therapy},
       ISSN = {0941-293X},
       DOI = {DOI 10.1007/s00347-003-0943-7},
       url = {<Go to ISI>://WOS:000222973300003},
       year = {2004},
       type = {Journal Article}
    }
    
  • Kirsch, C. and Schneider-Brachert, W. and Grossmann, D. and Ebert, S. and Schlichting, S. and Birngruber, R. and Morgner, A. and Madisch, A. and Stolte, M. and Lehn, N. and Miehlke, S.: The efficacy of omeprazole/esomeprazole-based first-line and rescue therapies for treatment of Helicobacter pylori infection is not affected by polymorphisms of cytochrome P450-2C19. Gastroenterology, no. 126, pp. A189-A189, 2004
    BibTeX Link
    @article{Kirsch2004,
       author = {Kirsch, C. and Schneider-Brachert, W. and Grossmann, D. and Ebert, S. and Schlichting, S. and Birngruber, R. and Morgner, A. and Madisch, A. and Stolte, M. and Lehn, N. and Miehlke, S.},
       title = {The efficacy of omeprazole/esomeprazole-based first-line and rescue therapies for treatment of Helicobacter pylori infection is not affected by polymorphisms of cytochrome P450-2C19},
       journal = {Gastroenterology},
       volume = {126},
       number = {4},
       pages = {A189-A189},
       note = {Suppl. 2
    813EK
    Times Cited:0
    Cited References Count:0},
       ISSN = {0016-5085},
       url = {<Go to ISI>://WOS:000220890200944},
       year = {2004},
       type = {Journal Article}
    }
    
  • Framme, C and Schüle, G and Birngruber, R and Roider, J and Schütt, F and Kopitz, J and Holz, F and Brinkmann, R: Temperature dependent fluorescence of A2-E, the main fluorescent lipofuscin component in the RPE. no. 29, pp. 287-291, 2004
    BibTeX
    @article{Framme,
       author = {Framme, C and Schüle, G and Birngruber, R and Roider, J and Schütt, F and Kopitz, J and Holz, F and Brinkmann, R},
       title = {Temperature dependent fluorescence of A2-E, the main fluorescent lipofuscin component in the RPE},
       journal = {Curr Eye Res},
       volume = {29},
       number = {4-5},
       pages = {287-291},
       year = {2004}
    }
  • Roach, W. P. and Cain, C. P. and Narayan, D. G. and Noojin, G. D. and Boppart, S. A. and Birngruber, R. and Fujimoto, J. G. and Toth, C. A.: Retinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot size. Journal of Biomedical Optics, no. 9, pp. 1288-1296, 2004
    BibTeX Link
    @article{Roach2004,
       author = {Roach, W. P. and Cain, C. P. and Narayan, D. G. and Noojin, G. D. and Boppart, S. A. and Birngruber, R. and Fujimoto, J. G. and Toth, C. A.},
       title = {Retinal response of Macaca mulatta to picosecond laser pulses of varying energy and spot size},
       journal = {Journal of Biomedical Optics},
       volume = {9},
       number = {6},
       pages = {1288-1296},
       note = {879DU
    Times Cited:2
    Cited References Count:19},
       abstract = {We investigate the relationship between the laser beam at the retina (spot size) and the extent of retinal injury from single ultrashort laser pulses. From previous studies it is believed that the retinal effect of single 3-ps laser pulses should vary in extent and location, depending on the occurrence of laser-induced breakdown (LIB) at the site of laser delivery. Single 3-ps pulses of 580-nm laser energy are delivered over a range of spot sizes to the retina of Macaca mulatta. The retinal response is captured sequentially with optical coherence tomography (OCT). The in vivo OCT images and the extent of pathology on final microscopic sections of the laser site are compared. With delivery of a laser pulse with peak irradiance greater than that required for LIB, OCT and light micrographs demonstrate inner retinal injury with many intraretinal and/or vitreous hemorrhages. In contrast, broad outer retinal injury with minimal to no choriocapillaris effect is seen after delivery of laser pulses to a larger retinal area (60 to 300 mum diam) when peak irradiance is less than that required for LIB. The broader lesions extend into the inner retina when higher energy delivery produces intraretinal injury. Microscopic examination of stained fixed tissues provide better resolution of retinal morphology than OCT. OCT provides less resolution but could be guided over an in vivo, visible retinal lesion for repeated sampling over time during the evolution of the lesion formation. For 3-ps visible wavelength laser pulses, varying the spot size and laser energy directly affects the extent of retinal injury. This again is believed to be partly due to the onset of LIB, as seen in previous studies. Spot-size dependence should be considered when comparing studies of retinal effects or when pursuing a specific retinal effect from ultrashort laser pulses. (C) 2004 Society of Photo-Optical Instrumentation Engineers.},
       keywords = {histopathology
    laser
    laser-tissue interaction
    ophthalmology
    optical coherence tomography
    retina
    ultrashort laser pulses
    wound healing
    induced breakdown thresholds
    optical coherence tomography
    aqueous-media
    1st-order model
    lesions
    damage
    computation
    injury},
       ISSN = {1083-3668},
       DOI = {Doi 10.1117/1.1805554},
       url = {<Go to ISI>://WOS:000225697400023},
       year = {2004},
       type = {Journal Article}
    }
    
  • Mori, H and Hayashi, Y: Repair of leaking blebs using conunctiva and adjacent half-thickness cornea as free autografts.. Japanese Journal of Clinical Ophthalmology, no. 58, pp. 1695-1698, 2004
    BibTeX
    @article{Hayashi,
       author = {Mori, H and Hayashi, Y},
       title = {Repair of leaking blebs using conunctiva and adjacent half-thickness cornea as free autografts.},
       journal = {Japanese Journal of Clinical Ophthalmology},
       volume = {58},
       number = {9},
       pages = {1695-1698},
       year = {2004}
    }
    
  • Roegener, J and Brinkmann, R and Lin, C P: Pump-probe detection of laser-induced microbubble formation in retinal pigment epithelium cells. J Biomedical Optics, no. 9, pp. 367-371, 2004
    BibTeX
    @article{Roegener,
       author = {Roegener, J and Brinkmann, R and Lin, C P},
       title = {Pump-probe detection of laser-induced microbubble formation in retinal pigment epithelium cells},
       journal = {J Biomedical Optics},
       volume = {9},
       number = {2},
       pages = {367-371},
       year = {2004}
    }
    
  • Framme, C. and Schule, G. and Roider, J. and Birngruber, R. and Brinkmann, R.: Online autofluorescence measurements during selective RPE laser treatment. no. 242, pp. 863-9, Oct, 2004
    BibTeX
    @misc{Framme,
       author = {Framme, C. and Schule, G. and Roider, J. and Birngruber, R. and Brinkmann, R.},
       title = {Online autofluorescence measurements during selective RPE laser treatment},
       volume = {242},
       number = {10},
       pages = {863-9},
       month = {Oct},
       note = {0721-832X (Print)
    Journal Article},
       abstract = {BACKGROUND: Fundus autofluorescence (AF) is derived from the lipofuscin contained by the retinal pigment epithelial cells. Using a scanning laser ophthalmoscope, two-dimensional AF measurements of the ocular fundus can be achieved. Directly after conventional photocoagulation and also after selective RPE laser treatment (SRT) with ophthalmoscopically non-visible laser lesions, irradiated areas reveal reduced AF, indicating RPE damage. Since the green treatment laser beam could also be used for AF excitation, the aim of this study was to evaluate whether absolute measurements of AF can be performed, and also possible changes in AF detected, online during SRT. METHODS: SRT was carried out by use of a frequency-doubled Nd:YLF laser (wavelength 527 nm, pulse duration 1.7 micros, repetition rate 500 and 100 Hz, number of pulses 100 and 30, single pulse energy 50-130 microJ) in vitro (porcine RPE; retinal spot size 160 microm) and during patient treatment (retinal spot size 176 microm). During irradiation, fluorescence light from the RPE was decoupled from the laser light inside the slit lamp and detected by a photomultiplier or photodiode at wavelengths above 550 nm. Additionally, temperature-dependent fluorescence intensity measurements of A2-E, the main fluorescent component of lipofuscin, were performed in a different in-vitro setup. RESULTS: The intensity of AF decreased over the number of applied pulses during laser irradiation, and this trend was more pronounced in porcine RPE samples than during human treatment. In vitro, the AF intensity decreased by about 22%; however, only a weak signal was detected. When treating patients, the AF intensity was strong and the rate of decay of fluorescence intensity with number of pulses was greater when irradiating at 500 Hz than at the 100 Hz repetition rate. However, for both repetition rates the AF decay was merely up to 6-8% over the number of pulses per laser spot. Fluorescence intensity of A2-E decreased linearly with increasing temperature at about 1% per 1 degrees C and was completely reversible. CONCLUSIONS: Online measurements of AF during selective RPE laser treatment are possible and reveal a decay in AF as a function of the number of laser pulses applied to the RPE. If A2-E results can be transferred to RPE fluorescence, the AF decay could be related to the temperature increase within the tissue during treatment. Further clinical studies-in SRT as well as in conventional laser photocoagulation-might be able to show online AF changes on different areas of the retina and on different pathologies. Due to the temperature dependence of the fluorescence, on-line AF measurements during laser treatments such as photocoagulation or TTT may be able to be used as a real-time method for temperature monitoring.},
       keywords = {Animals
    Diabetic Retinopathy/*surgery
    *Fluorescence
    Humans
    *Laser Coagulation
    Lasers/diagnostic use
    Lipofuscin/*metabolism
    Ophthalmoscopy/methods
    Pigment Epithelium of Eye/*metabolism/surgery
    Swine},
       year = {2004}
    }
  • Brinkmann, R. and Poerksen, E. and Elsner, H. and Schuele, G. and Theisen-Kunde, D. and Roider, J. and Birngruber, R.: On-line dosimetry for selective retina treatment (SRT). Investigative Ophthalmology & Visual Science, no. 45, pp. U763-U763, 2004
    BibTeX Link
    @article{Brinkmann2004,
       author = {Brinkmann, R. and Poerksen, E. and Elsner, H. and Schuele, G. and Theisen-Kunde, D. and Roider, J. and Birngruber, R.},
       title = {On-line dosimetry for selective retina treatment (SRT)},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {45},
       pages = {U763-U763},
       note = {Suppl. 1
    846TA
    2032
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000223338001991},
       year = {2004},
       type = {Journal Article}
    }
    
  • Klatt, C. and Bunse, A. and Elsner, H. and Poerksen, E. and Theisen, D. and Brinkman, R. and Hamilton, P. and Birngruber, R. and Laqua, H. and Roider, J.: OCT-findings in patients treated with Selective-RPE-laser-treatment (SRT). Investigative Ophthalmology & Visual Science, no. 45, pp. U366-U366, 2004
    BibTeX Link
    @article{Klatt2004,
       author = {Klatt, C. and Bunse, A. and Elsner, H. and Poerksen, E. and Theisen, D. and Brinkman, R. and Hamilton, P. and Birngruber, R. and Laqua, H. and Roider, J.},
       title = {OCT-findings in patients treated with Selective-RPE-laser-treatment (SRT)},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {45},
       pages = {U366-U366},
       note = {Suppl. 2
    846TC
    4091
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000223338201285},
       year = {2004},
       type = {Journal Article}
    }
    
  • Schüle, G. and Framme, C. and Roider, J. and Brinkmann, R: Noninvasive optoacoustic temperature determination at the fundus of the eye during laser irradiation. Journal of Biomedical Optics, no. 9, pp. 173-179, 2004
    BibTeX
    @article{Schüle,
       author = {Schüle, G. and Framme, C. and Roider, J. and Brinkmann, R},
       title = {Noninvasive optoacoustic temperature determination at the fundus of the eye during laser irradiation},
       journal = {Journal of Biomedical Optics},
       volume = {9},
       number = {1},
       pages = {173-179},
       year = {2004}
    }
    
  • Brendel, T and Brinkmann, R: Mid-IR laser induced superheating of water and its quantification by an optical temperature probe. Appl Optics, no. 43, pp. 1856-1862, 2004
    BibTeX
    @article{Brendel,
       author = {Brendel, T and Brinkmann, R},
       title = {Mid-IR laser induced superheating of water and its quantification by an optical temperature probe},
       journal = {Appl Optics},
       volume = {43},
       number = {9},
       pages = {1856-1862},
       year = {2004}
    }
  • Löning, M. and Diddens, H. and W, Küpker and Diedrich, K. and Hüttmann, G.: Laparoscopic Fluorescence Detection of Ovarian Carcinoma Metastases Using 5-Aminolevulinic Acid-Induced Protoporphyrin IX. no. 100, 2004
    BibTeX
    @article{Löning,
       author = {Löning, M. and Diddens, H. and W, Küpker and Diedrich, K. and Hüttmann, G.},
       title = {Laparoscopic Fluorescence Detection of Ovarian Carcinoma Metastases Using 5-Aminolevulinic Acid-Induced Protoporphyrin IX},
       journal = {CANCER},
       volume = {100},
       number = {8},
       year = {2004}
    }
    
    
  • Rau, K.R. and Vogel, A. and Venugopalan, V.: Investigation of laser-induced cell lysis using time-resolved imaging. Appl Phys Lett, no. 84, pp. 2940-2942, 2004
    BibTeX
    @article{Rau,
       author = {Rau, K.R. and Vogel, A. and Venugopalan, V.},
       title = {Investigation of laser-induced cell lysis using time-resolved imaging},
       journal = {Appl Phys Lett},
       volume = {84},
       number = {15},
       pages = {2940-2942},
       year = {2004}
    }
    
  • Framme, C. and Schuele, G. and Roider, J. and Birngruber, R. and Brinkmann, R.: Influence of pulse duration and pulse number in selective RPE laser treatment. Lasers Surg Med, no. 34, pp. 206-15, 2004
    BibTeX
    @article{Framme,
       author = {Framme, C. and Schuele, G. and Roider, J. and Birngruber, R. and Brinkmann, R.},
       title = {Influence of pulse duration and pulse number in selective RPE laser treatment},
       journal = {Lasers Surg Med},
       volume = {34},
       number = {3},
       pages = {206-15},
       note = {0196-8092 (Print)
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {BACKGROUND AND OBJECTIVES: The therapeutic effect of laser treatment for macular diseases is related to the damage to the retinal pigment epithelium (RPE) and the subsequent restoration of the defect due to RPE proliferation. In contrast to conventional laser treatment, it is possible to damage the RPE selectively and to spare the photoreceptors by using repetitive microsecond laser pulses. It was the aim of the study to investigate the influence of pulse duration and number of pulses on angiographically and ophthalmoscopically visible retinal damage thresholds in order to optimize treatment modalities. STUDY DESIGN/MATERIALS AND METHODS: In total, 625 laser lesions with various parameters were applied to the retina in 11 eyes of 6 Chinchilla breed rabbits using an experimental laser system (Nd:YLF at 527 nm). Pulse duration (1.7 microseconds and 200 nanoseconds) and number of pulses (100, 10, and 1 pulses) were varied at a constant repetition rate of 100 Hz. Damage thresholds were determined in terms of ophthalmoscopic and fluorescein angiographic visibility, and the therapeutic window (TW; angiographic ED(50) vs. ophthalmoscopic ED(50)) as well as the safety range (SR; angiographic ED(84) vs. ophthalmoscopic ED(16)) between both thresholds were calculated. Selected laser lesions were evaluated by histology. RESULTS: Generally, the ED(50) radiant exposure for angiographic visibility decreases for shorter laser pulses and with an increase in the number of pulses. The TW for both pulse durations (1.7 microseconds and 200 nanoseconds) was wider with 100 pulses than with single pulses. The widest TW was found for 100 pulses at 200 nanoseconds pulse duration (5.9-fold above the angiographic threshold), and the smallest TW with a factor of 1.6 was found for 1.7 microseconds single pulses. In terms of SR, only irradiation with 100 pulses at 200 nanoseconds pulse duration was associated with a ratio >2. Independently of pulse duration, histological examination of laser sites 1 hour after irradiation revealed widely intact photoreceptors, while the underlying RPE was damaged. CONCLUSIONS: Pulse duration and number of pulses have a significant influence on RPE damage thresholds and consecutively on TW and SR. Because fundus pigmentation in humans may vary intra- and interindividually by a factor of 2, a large TW and ideally also a large SR should be ensured in a clinical treatment context. In rabbits, the safety range with 200 nanoseconds pulses is higher than with the pulse duration of 1.7 microseconds currently in clinical use. These findings suggest the need for clinical pilot studies to prove whether these results can be transposed to the situation in humans.},
       keywords = {Animals
    *Laser Coagulation/adverse effects
    Pigment Epithelium of Eye/*injuries
    Rabbits
    Time Factors},
       year = {2004}
    }
  • Daniltchenko, D. and Lankenau, E. and König, F. and Shay, B. and Hüttmann, G. and Sachs, M.D. and Schnorr, D.: In Vivo Optical Coherence Tomography in Endoscopic Diagnosis of Bladder Disease. in Clinical technoligies and systems, no. 5316, pp. 473-478, Proc Soc Photo-Opt Instrum Eng, SPIE 2004, 2004
    BibTeX
    @inbook{Daniltchenko,
       author = {Daniltchenko, D. and Lankenau, E. and König, F. and Shay, B. and Hüttmann, G. and Sachs, M.D. and Schnorr, D.},
       title = {In Vivo Optical Coherence Tomography in Endoscopic Diagnosis of Bladder Disease},
       booktitle = {Clinical technoligies and systems},
       editor = {Vo-Dinh, Tuan},
       publisher = {Proc Soc Photo-Opt Instrum Eng, SPIE 2004},
       volume = {5316},
       pages = {473-478},
       year = {2004}
    }
  • Kracht, D. and Brinkmann, R: Green Q-switched microsecond laser pulses by overcoulped intracavity second harmonic generation. no. 231, pp. 319-324, 2004
    BibTeX
    @misc{Kracht,
       author = {Kracht, D. and Brinkmann, R},
       title = {Green Q-switched microsecond laser pulses by overcoulped intracavity second harmonic generation},
       volume = {231},
       pages = {319-324},
       year = {2004}
    }
    
  • Ahlers, C. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.: Differentiation of lesion types in exsudative age-related macular degeneration using current imaging methods. Investigative Ophthalmology & Visual Science, no. 45, pp. U61-U61, 2004
    BibTeX
    @article{Ahlers2004,
       author = {Ahlers, C. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.},
       title = {Differentiation of lesion types in exsudative age-related macular degeneration using current imaging methods},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {45},
       pages = {U61-U61},
       note = {Suppl. 2
    846TC
    3071
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000223338200273},
       year = {2004},
       type = {Journal Article}
    }
    
  • Ahlers, C. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.: Differentiation of lesion types in exsudative age-related macular degeneration using current imaging methods. Investigative Ophthalmology & Visual Science, no. 45, pp. U61-U61, 2004
    BibTeX Link
    @article{Ahlers2004,
       author = {Ahlers, C. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.},
       title = {Differentiation of lesion types in exsudative age-related macular degeneration using current imaging methods},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {45},
       pages = {U61-U61},
       note = {Suppl. 2
    846TC
    3071
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000223338200273},
       year = {2004},
       type = {Journal Article}
    }
    
  • Framme, C. and Flucke, B. and Birngruber, R.: Comparison of reduced and standard light application in photodynamic treatment in two rabbit models. Investigative Ophthalmology & Visual Science, no. 45, pp. U81-U81, 2004
    BibTeX Link
    @article{Framme2004,
       author = {Framme, C. and Flucke, B. and Birngruber, R.},
       title = {Comparison of reduced and standard light application in photodynamic treatment in two rabbit models},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {45},
       pages = {U81-U81},
       note = {Suppl. 2
    846TC
    3189
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000223338200390},
       year = {2004},
       type = {Journal Article}
    }
    
  • Porksen, E. and Elsner, H. and Theisen-Kunde, D. and Brinkmann, R. and Klatt, C. and Bunse, A. and Hamilton, P. and Birngruber, R. and Lagua, H. and Roider, J.: Clinical application of optoacoustic on-line dosimetry in Selective-RPE-laser-treatment (SRT). Investigative Ophthalmology & Visual Science, no. 45, pp. U363-U363, 2004
    BibTeX Link
    @article{Porksen2004,
       author = {Porksen, E. and Elsner, H. and Theisen-Kunde, D. and Brinkmann, R. and Klatt, C. and Bunse, A. and Hamilton, P. and Birngruber, R. and Lagua, H. and Roider, J.},
       title = {Clinical application of optoacoustic on-line dosimetry in Selective-RPE-laser-treatment (SRT)},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {45},
       pages = {U363-U363},
       note = {Suppl. 2
    846TC
    4074
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000223338201270},
       year = {2004},
       type = {Journal Article}
    }
    
  • Helbing, Jan and Bregy, Harald and Bredenbeck, Jens and Pfister, Rolf and Hamm, Peter and Huber, Robert and Wachtveitl, Josef and De Vico, Luca and Olivucci, Massimo: A fast photoswitch for minimally perturbed peptides: investigation of the trans->cis photoisomerization of N-methylthioacetamide.. Journal of the American Chemical Society, no. 126, pp. 8823-34, jul,, 2004
    BibTeX Link
    @Article{HU_2004_Helbing_a,
      Title                    = {{A fast photoswitch for minimally perturbed peptides: investigation of the trans-->cis photoisomerization of N-methylthioacetamide.}},
      Author                   = {Helbing, Jan and Bregy, Harald and Bredenbeck, Jens and Pfister, Rolf and Hamm, Peter and Huber, Robert and Wachtveitl, Josef and {De Vico}, Luca and Olivucci, Massimo},
      Journal                  = {Journal of the American Chemical Society},
      Year                     = {2004},
    
      Month                    = jul,
      Number                   = {28},
      Pages                    = {8823--34},
      Volume                   = {126},
    
      Doi                      = {10.1021/ja049227a},
      ISSN                     = {0002-7863},
      Url                      = {http://pubs.acs.org/doi/abs/10.1021/ja049227a}
    }

2003

  • Framme, C. and Alt, C. and Schuele, G. and Brinkmann, R. and Birngruber, R. and Lin, C.: Threshold determinations for selective RPE laser treatment with a laser scanner in rabbits with different scan times in the microsecond regime. Investigative Ophthalmology & Visual Science, no. 44, pp. U663-U663, 2003
    BibTeX Link
    @article{Framme2003,
       author = {Framme, C. and Alt, C. and Schuele, G. and Brinkmann, R. and Birngruber, R. and Lin, C.},
       title = {Threshold determinations for selective RPE laser treatment with a laser scanner in rabbits with different scan times in the microsecond regime},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {44},
       pages = {U663-U663},
       note = {Suppl. 2
    709CK
    4865
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000184607002325},
       year = {2003},
       type = {Journal Article}
    }
    
  • Niemeyer, M. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.: Three-dimensional imaging of photodynamic effects in choroidal neovascularization and collateral choroid. Investigative Ophthalmology & Visual Science, no. 44, pp. U297-U297, 2003
    BibTeX Link
    @article{Niemeyer2003,
       author = {Niemeyer, M. and Michels, S. and Birngruber, R. and Schmidt-Erfurth, U.},
       title = {Three-dimensional imaging of photodynamic effects in choroidal neovascularization and collateral choroid},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {44},
       pages = {U297-U297},
       note = {Suppl. 1
    709CH
    1098
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000184606801048},
       year = {2003},
       type = {Journal Article}
    }
    
  • Roider, J. and Brinkmann, R. and Birngruber, R.: Selective retinal pigment epithelium laser treatment - Theoretical and clinical aspects. in Lasers in Ophthalmology - Basic, Diagnostic and Surgical Aspects, pp. 119-129, Kugler Publications, The Hague, The Netherlands, 2003
    BibTeX
    @inbook{Roider,
       author = {Roider, J. and Brinkmann, R. and Birngruber, R.},
       title = {Selective retinal pigment epithelium laser treatment -   Theoretical and clinical aspects},
       booktitle = {Lasers in Ophthalmology - Basic, Diagnostic and Surgical Aspects},
       editor = {Fankhauser, F. and Kwasniewska, S.},
       publisher = {Kugler Publications, The Hague, The Netherlands},
       pages = {119-129},
       year = {2003}
    }
    
  • Löning, M. and Lankenau, E. and Strunck, C. and Krokowski, M. and Hillbricht, S. and Diedrich, K. and Hüttmann, G.: Optische Kohärenztomographie - ein neues hochauflösendes Schnittbildverfahren als Ergänzung zur Kolposkopie. Geburtsh Frauenheilk, no. 63, pp. 1158-1161, 2003
    BibTeX
    @article{Löning,
       author = {Löning, M. and Lankenau, E. and Strunck, C. and Krokowski, M. and Hillbricht, S. and Diedrich, K. and Hüttmann, G.},
       title = {Optische Kohärenztomographie - ein neues hochauflösendes Schnittbildverfahren als Ergänzung zur Kolposkopie},
       journal = {Geburtsh Frauenheilk},
       volume = {63},
       pages = {1158-1161},
       year = {2003}
    }
    
  • Vogel, A. and Venugopalan, V.: Mechanisms of Pulsed Laser Ablation of Biological Tissues. Chem. Rev., no. 103, pp. 577-644, 2003
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Venugopalan, V.},
       title = {Mechanisms of Pulsed Laser Ablation of Biological Tissues},
       journal = {Chem. Rev.},
       volume = {103},
       pages = {577-644},
       year = {2003}
    }
    
  • Vogel, Alfred: Mechanism of short-pulsed plasma-mediated laser ablation and disruption. in Lasers in Ophthalmology - Basic, Diagnostic and Surgical Aspects, pp. pp. 99-113, Kugler Publications, The Hague, The Netherlands, 2003
    BibTeX
    @inbook{Vogel,
       author = {Vogel, Alfred},
       title = {Mechanism of short-pulsed plasma-mediated laser ablation and disruption},
       booktitle = {Lasers in Ophthalmology - Basic, Diagnostic and Surgical Aspects},
       editor = {Frankenhauser, F. and Kwasniewska, S.},
       publisher = {Kugler Publications, The Hague, The Netherlands},
       pages = {pp. 99-113},
       year = {2003}
    }
    
  • Diddens, H. and Fischer, F. and Pottier, R. H.: In-vivo investigations on dye-enhanced photothermal tumor therapy with a naphthalocyanine derivative. Oftalmologia, no. 56, pp. 59-61, 2003
    BibTeX
    @article{Diddens,
       author = {Diddens, H. and Fischer, F. and Pottier, R. H.},
       title = {In-vivo investigations on dye-enhanced photothermal tumor therapy with a naphthalocyanine derivative},
       journal = {Oftalmologia},
       volume = {56},
       number = {1},
       pages = {59-61},
       note = {Diddens, Heyke
    Fischer, Frank
    Pottier, Roy H
    Romania
    Bucharest, Romania : 1990
    Oftalmologia. 2003;56(1):59-61.},
       abstract = {Chromophore-enhanced photothermal therapy involves the application of an exogenous chromophore in combination with irradiation, using an appropriate wavelength, exposure duration and sufficient irradiances. The chromophore palladium(II) octabutoxynaphthalocyanine (PdNc(OBu)8) accumulates at satisfactory concentrations and with good selectivity between both tumor and muscle and tumor and skin in tumor-bearing mice. In an attempt to thermally damage tumor tissue with concurrent sparing of adjacent normal tissue, the potential of PdNc(OBu)8 for photothermal therapy was investigated. Using a Balb/c mouse model with subcutaneously implanted EMT6 adenocarcinoma, 90-100 hours after intraperitoneal application of PdNc(OBu)8, the tumor and surrounding tissue were irradiated with a 826nm continuous-wave diode laser. The thermal effects on tumor and normal tissue were evaluated histologically. Our results indicate that after PdNc(OBu)8 administration and tumor irradiation using 5W/cm-for 100 seconds, pronounced selective heating of the tumor was achieved in mice, while in control animals merely an unspecific and marginal overall increase in temperature over the entire irradiation area was observed. Histological evaluation of treated areas indicated that the PdNc(OBu)8-targeted tumor tissue showed severe thermal damage while peripheral tissue like skin and muscle remained largely unaffected. This study shows the potential of creating localized thermal effects by using PdNc(OBu)8 and continuous-wave light for chromophore-enhanced photothermal therapy.},
       keywords = {Adenocarcinoma/*therapy
    Animals
    Disease Models, Animal
    Female
    Hindlimb
    Lasers
    Mice
    Mice, Inbred BALB C
    Organometallic Compounds/*therapeutic use
    Photochemotherapy/*methods
    Soft Tissue Neoplasms/*therapy
    Treatment Outcome},
       year = {2003}
    }
    
  • Miura, Y. and Yanagihara, N. and Imamura, H. and Kaida, M. and Moriwaki, M. and Shiraki, K. and Miki, T.: Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro. Jpn J Ophthalmol, no. 47, pp. 268-75, 2003
    BibTeX
    @article{Miura2003,
       author = {Miura, Y. and Yanagihara, N. and Imamura, H. and Kaida, M. and Moriwaki, M. and Shiraki, K. and Miki, T.},
       title = {Hepatocyte growth factor stimulates proliferation and migration during wound healing of retinal pigment epithelial cells in vitro},
       journal = {Jpn J Ophthalmol},
       volume = {47},
       number = {3},
       pages = {268-75},
       note = {Miura, Yoko
    Yanagihara, Nobuyo
    Imamura, Hitoshi
    Kaida, Mayumi
    Moriwaki, Mitsuyasu
    Shiraki, Kunihiko
    Miki, Tokuhiko
    eng
    Research Support, Non-U.S. Gov't
    2003/06/05 05:00
    Jpn J Ophthalmol. 2003 May-Jun;47(3):268-75.},
       abstract = {PURPOSE: A defect in retinal pigment epithelial (RPE) cells may cause dysfunction of the neural retina, so rapid recovery of differentiated RPE cells is required after RPE injury. We investigated the effect of hepatocyte growth factor (HGF) on wound healing in RPE cells. METHODS: Confluent monolayers of bovine RPE cells were denuded, and the cells were allowed to recover in the presence or absence of HGF. The effect of HGF on RPE cell proliferation was evaluated by a 3-(4;5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tet raz olium assay. In a migration assay, mitomycin C was used to inhibit proliferation, and the number of migrated cells was counted. The signaling pathways involved were examined using inhibitors of mitogen-activated protein kinase (MAPK), phosphatidylinositol-3 (PI3) kinase and protein kinase C pathways. RESULTS: At 80 ng/mL, HGF stimulated the wound closure of RPE monolayers and rendered the restituted cells more epithelioid in shape. HGF at 10 ng/mL stimulated RPE cell migration the most, whereas 80 ng/mL of HGF inhibited migration, but stimulated proliferation the most. In particular, PI3 kinase and MAPK inhibitor inhibited PRE cell migration and proliferation, respectively. CONCLUSIONS: HGF stimulated wound closure in cultured RPE cells, and rendered restituted cells epithelioid in shape. HGF may become a therapeutic candidate for RPE wound healing.},
       keywords = {Animals
    Cattle
    Cell Count
    Cell Division/*drug effects
    Cell Movement/*drug effects
    Cells, Cultured
    Enzyme Inhibitors/pharmacology
    Hepatocyte Growth Factor/*pharmacology
    Mitogen-Activated Protein Kinases/antagonists & inhibitors
    Phosphatidylinositol 3-Kinases/antagonists & inhibitors
    Pigment Epithelium of Eye/*cytology/physiology
    Protein Kinase C/antagonists & inhibitors
    Signal Transduction
    Wound Healing/*drug effects},
       year = {2003}
    }
    
  • Teschner, S. and Noack, J. and Birngruber, R. and Schmidt-Erfurth, U.: Characterization of leakage activity in exudative chorioretinal disease with three-dimensional confocal angiography. Ophthalmology, no. 110, pp. 687-697, 2003
    BibTeX Link Link
    @article{Teschner2003,
       author = {Teschner, S. and Noack, J. and Birngruber, R. and Schmidt-Erfurth, U.},
       title = {Characterization of leakage activity in exudative chorioretinal disease with three-dimensional confocal angiography},
       journal = {Ophthalmology},
       volume = {110},
       number = {4},
       pages = {687-697},
       note = {673EE
    Times Cited:8
    Cited References Count:30},
       abstract = {Purpose: A novel angiographic technique providing topographic imaging of chorioretinal fluorescence is applied to the characterization of leakage dynamics in exudative chorioretinopathy. The three-dimensional imaging is evaluated with respect to results with conventional two-dimensional fluorescence angiography.
    Design: Prospective observational case series.
    Participants: Thirty eyes of 30 patients with different exudative maculopathies (pigment epithelium detachment, branch retinal vein occlusion, central serous chorioretinopathy, each n = 10) and 11 eyes of 10 patients with clinically normal appearance.
    Methods: Depth-resolved fluorescence angiography using a confocal scanning laser system was performed after complete ophthalmologic examination. The axial distribution of fluorescein and indocyanine green fluorescence at each x/y position within a tomographic scan of 32 images was analyzed. The chorioretinal fluorescence topography was reconstructed by localizing a defined threshold value of fluorescence and displayed as topographic relief. Qualitative description and quantitative measurements of exudation or structural alterations were performed topographically and conventionally.
    Main Outcome Measures. Qualitative and quantitative analysis of structural or exudative changes in time course in topographic illustration compared with conventional angiography.
    Results: Clinically physiologic eyes were presented topographically as a smooth concave surface of fluorescence with defined illustration of retinal vascular structures and the optic disc. Retinal vascular pathologic conditions induce a precisely demarcated pattern of intraretinal edema with a characteristic temporal evolution. In central serous retinopathy the underlying pathologic condition was identified as a perfusion defect, which was subsequently filled with a peak of exudation with differences in the time of maximum in fluorescein/indocyanine green angiography. Pigment epithelium detachment appeared as a high and well defined elevation, with the origin of exudation within the base of the detachment. Differences in the time of maximum prominence were found in indocyanine green angiography within the pigment epithelium detachment group.
    Conclusions: Confocal topographic angiography allows for the first time precise three-dimensional functional imaging of fundus alterations caused by leakage or barrier dysfunction. Compared with conventional angiography, depth-resolved angiographic imaging is less impaired by masking phenomena or low fluorescence intensity, which improves the diagnostic yield of angiography. The characterization and quantification of leakage activity is a promising tool in the assessment of exudative maculopathy. (C) 2003 by the American Academy of Ophthalmology.},
       keywords = {indocyanine green angiography
    scanning laser ophthalmoscope
    central serous chorioretinopathy
    choroidal neovascularization
    macular degeneration
    topographic angiography
    retinal thickness
    fluorescein
    videoangiography
    tomography},
       ISSN = {0161-6420},
       DOI = {Doi 10.1016/S6420(02)01972-3},
       url = {<Go to ISI>://WOS:000182566600026},
       year = {2003},
       type = {Journal Article}
    }
    
  • Huber, Robert and Moser, Jacques E and Gratzel, Michael and Wachtveitl, Josef L: Beyond vibrationally mediated electron transfer: interfacial charge injection on a sub-10-fs time scale. in Optical Science and Technology, SPIE`s 48th Annual Meeting, pp. 121-131, International Society for Optics and Photonics, dec,, 2003
    BibTeX Link
    @InProceedings{HU_2003_Huber_b,
      Title                    = {{Beyond vibrationally mediated electron transfer: interfacial charge injection on a sub-10-fs time scale}},
      Author                   = {Huber, Robert and Moser, Jacques E and Gratzel, Michael and Wachtveitl, Josef L},
      Booktitle                = {Optical Science and Technology, SPIE's 48th Annual Meeting},
      Year                     = {2003},
      Editor                   = {Lian, Tianquan and Dai, Hai-Lung},
      Month                    = dec,
      Pages                    = {121--131},
      Publisher                = {International Society for Optics and Photonics},
    
      Doi                      = {10.1117/12.506722},
      Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=828500}
    }
  • Huber, R and Moser, J.E. and Grutzet, M and Wachtveitl, J: Beyond vibrationally mediated electron transfer: coherent phenomena in a sub-10-femtosecond reaction regime. 2003 European Quantum Electronics Conference. EQEC 2003 (IEEE Cat No.03TH8665), pp. 158, IEEE, 2003
    BibTeX Link
    @Article{HU_2003_Huber_a,
      Title                    = {{Beyond vibrationally mediated electron transfer: coherent phenomena in a sub-10-femtosecond reaction regime}},
      Author                   = {Huber, R and Moser, J.E. and Grutzet, M and Wachtveitl, J},
      Journal                  = {2003 European Quantum Electronics Conference. EQEC 2003 (IEEE Cat No.03TH8665)},
      Year                     = {2003},
      Pages                    = {158},
    
      Doi                      = {10.1109/EQEC.2003.1314015},
      ISBN                     = {0-7803-7733-8},
      Publisher                = {IEEE},
      Url                      = {http://ieeexplore.ieee.org/lpdocs/epic03/wrapper.htm?arnumber=1314015}
    }
    
  • Vogel, A. and Venugopalan, V.: Additions and Corrections. Chemical Reviews, no. 103, pp. 2079, 2003
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Venugopalan, V.},
       title = {Additions and Corrections},
       journal = {Chemical Reviews},
       volume = {103},
       number = {5},
       pages = {2079},
       year = {2003}
    }