2006 - 2005

2006

  • Ahlers, C. and Michels, S. and Beckendorf, A. and Birngruber, R. and Schmidt-Erfurth, U.: Three-dimensional imaging of pigment epithelial detachment in age-related macular degeneration using optical coherence tomography, retinal thickness analysis and topographic angiography. Graefes Archive for Clinical and Experimental Ophthalmology, no. 244, pp. 1233-1239, 2006
    BibTeX Link
    @article{Ahlers2006,
    
       author = {Ahlers, C. and Michels, S. and Beckendorf, A. and Birngruber, R. and Schmidt-Erfurth, U.},
       title = {Three-dimensional imaging of pigment epithelial detachment in age-related macular degeneration using optical coherence tomography, retinal thickness analysis and topographic angiography},
       journal = {Graefes Archive for Clinical and Experimental Ophthalmology},
       volume = {244},
       number = {10},
       pages = {1233-1239},
       note = {087FX
    Times Cited:16
    Cited References Count:19},
       abstract = {Introduction: New diagnostic tools such as the retinal thickness analyzer (RTA), optical coherence tomography (OCT), and topographic angiography (TAG) were introduced into clinical ophthalmology during the last years giving the examiner new insights into anatomical and functional aspects of macular disease. In this study, advantages and disadvantages of the new imaging methods have been evaluated in patients with serous (sPED) and fibrovascular pigment epithelial detachments (fPED) secondary to age-related macular degeneration (AMD). Methods: TAG, using fluorescein angiography (FA), provides a three-dimensional profile of the fluorescein pattern based on the analysis of a set of 32 confocal images over a depth of 4 mm. RTA and OCT provide cross-sectional images of the neurosensory retina and the retinal pigment epithelium-choriocapillary complex as well as retinal thickness data encoded in a false color map. We compared and evaluated these modalities in 15 patients with fPED and 15 patients with sPED secondary to AMD. Results: In patients with classic fPED, TAG detected neovascular structures and delineated their configuration. In sPEDs, pooling of extravascular fluid was detected in a dome-shaped configuration. OCT provided detailed information on the neurosensory retina's structures but failed to detect the neovascular membrane in fPED. Mapping the retinal thickness, RTA and OCT both failed to detect the PED and showed typical algorithm error-based patterns. Conclusions: TAG OCT and RTA are useful imaging modalities in the evaluation of AMD cases. TAG visualizes the vascular configuration, dynamic perfusion, and leakage changes. OCT and RTA are able to complementarily document intra-, subretinal, and sub-RPE fluid accumulation secondary to CNV. However, OCT seems to be more efficient in imaging AMD-related pathologies than RTA, as this modality is often compromised by intra- or subretinal structural abnormalities. Nevertheless, all modalities may provide further valuable insight into AMD pathogenesis, enhance diagnostic quality, and improve the assessment of therapeutic effects.},
       keywords = {choroidal neovascularization
    pigment epithelial detachment (ped)
    topographic angiography
    retinal thickness analyzer
    age-related macular degeneration (amd)
    optical coherence tomography
    imaging
    choroidal neovascularization
    verteporfin therapy
    disease
    repeatability
    eyes
    oct
    tap},
       ISSN = {0721-832X},
       DOI = {DOI 10.1007/s00417-006-0418-z},
       url = {<Go to ISI>://WOS:000240729400003},
       year = {2006},
       type = {Journal Article}
    }
    
  • Brujan, EA. and Vogel, A .: Stress wave emission and cavitation bubble dynamics by nanosecond optical breakdown in a tissue phantom.. J Fluid Mech, no. 558, pp. 281-308, 2006
    BibTeX
    @article{Brujan,
       author = {Brujan, EA. and Vogel, A .},
       title = {Stress wave emission and cavitation bubble dynamics by nanosecond optical breakdown in a tissue phantom.},
       journal = { J Fluid Mech},
       volume = {558},
       pages = {281-308},
       year = {2006}
    }
  • Vogel, A. and Apitz, I. and Freidank, S. and Dijkink, R.: Sensitive high-resolution white-light Schlieren technique with a large dynamic range for the investigation of ablation dynamics. Opt. Lett., no. 31, pp. 1812-1814, 2006
    BibTeX
    @article{Vogel2006,
       author = {Vogel, A. and Apitz, I. and Freidank, S. and Dijkink, R.},
       title = {Sensitive high-resolution white-light Schlieren technique with a large dynamic range for the investigation of ablation dynamics},
       journal = {Opt. Lett.},
       volume = {31},
       pages = {1812-1814},
       year = {2006}
    }
  • Klatt, C. and Elsner, H. and Porksen, E. and Brinkmann, R. and Bunse, A. and Birngruber, R. and Roider, J.: Selektive Retina-Therapie bei Retinopathia centralis serosa mit Pigmentepithelabhebung. Ophthalmologe, no. 103, pp. 850-855, Aug, 2006
    BibTeX
    @article{Klatt,
       author = {Klatt, C. and Elsner, H. and Porksen, E. and Brinkmann, R. and Bunse, A. and Birngruber, R. and Roider, J.},
       title = {Selektive Retina-Therapie bei Retinopathia centralis serosa mit Pigmentepithelabhebung},
       journal = {Ophthalmologe},
       volume = {103},
       number = {10},
       pages = {850-855},
       note = {0941-293X (Print)
    Clinical Trial
    English Abstract
    Journal Article},
       month = {Aug},
       abstract = {Selective Retina Therapy (SRT) is a new laser treatment that selectively targets the retinal pigmen epithelium (RPE). In this study, we treated 39 patients presenting with nonischemic, focal and focal-diffuse diabetic maculopathy with SRT. In the main. the results indicate that SRT had stabilizing effects on visual acuity, angiographic leakage, lipid exudation, and foveal retinal thickness. SRT is safe and is especially useful for treating pathologies that are located close to the fovea, which cannot be treated with conventional argon laser photocoagulation.},
       keywords = {Aged
    Diabetic Retinopathy/*surgery
    Female
    Humans
    Laser Surgery/*methods
    Lasers/*therapeutic use
    Macular Degeneration/*surgery
    Male
    Ophthalmologic Surgical Procedures/*methods
    Preoperative Care/methods
    Treatment Outcome},
       year = {2006}
    }
  • Brinkmann, Ralf and Birngruber, Reginald: Selektive Retina-Therapie (SRT). Zeitschrift für Medizinische Physik, no. 17, pp. 6-22, 2006
    BibTeX
    @article{Brinkmann,
       author = {Brinkmann, Ralf and Birngruber, Reginald},
       title = {Selektive Retina-Therapie (SRT)},
       journal = {Zeitschrift für Medizinische Physik},
       volume = {17},
       number = {1},
       pages = {6-22},
       abstract = {Zusammenfassung Die am Medizinischen Laserzentrum Lübeck entwickelte selektive Retina-Therapie (SRT) wird zur Zeit als neue, schonende Laser-Behandlungsmethode für verschiedene Erkrankungen des Augenhintergrunds evaluiert, deren Ursachen einer Degradation des Retinalen Pigmentepithels (RPE) zugeschrieben werden. Mit der SRT lässt sich selektiv das RPE behandeln, ohne die angrenzende neurosensorische Netzhaut mit den Photorezeptoren und die unter dem RPE liegende Aderhaut (Choroidea) zu beeinträchtigen. Die Therapie führt idealerweise zu einer Regeneration des RPEs und einem gesteigerten Metabolismus am chorio-retinalen Übergang. Im Gegensatz zur etablierten Laserphotokoagulation, bei der die Netzhaut in und um die bestrahlten Areale komplett verödet wird, bleibt bei der SRT die Sehfähigkeit der Patienten in den bestrahlten Arealen erhalten. Der Artikel gibt einen Überblick über die Idee und die physikalischen Mechanismen selektiver RPE-Behandlung, die online Dosimetrie der optisch nicht sichtbaren Effekte und fasst die ersten klinischen Ergebnisse zusammen. Selective Retina Therapy (SRT) is a new and very gentle laser method developed at the Medical Laser Center Lübeck. It is currently investigated clinically in order to treat retinal disorders associated with a decreased function of the retinal pigment epithelium (RPE). SRT is designed to selectively effect the RPE while sparing the neural retina and the photoreceptors as well as the chorioidea. Aim of the therapy is the rejuvenation of the RPE in the treated areas, which should ideally lead to a long term metabolic increase at the chorio-retinal junction. In contrast to conventional laser photocoagulation, which is associated with a complete thermal necrosis of the treated site, SRT completely retains full vision. This paper reviews the methods and mechanisms behind selective RPE effects and reports the first clinical results. An online dosimetry technique to visualize the ophthalmoscopically invisible effects is introduced.},
       keywords = {Selektive Zelleffekte, Optoakustik, Mikroblasen, Online-Dosimetrie, RPE, ?s-Laserpulse, Makulaödeme, RCS
    Selective cellular effects, optoacoustics, online dosimetry, RPE, ?s-laser pulses, macula oedema, RCS},
       year = {2006}
    }
  • Brinkmann, Ralf and Birngruber, Reginald: Selektive Retina-Therapie (SRT). Zeitschrift für Medizinische Physik, no. 17, pp. 6-22, 2006
    BibTeX
    @article{Brinkmann,
       author = {Brinkmann, Ralf and Birngruber, Reginald},
       title = {Selektive Retina-Therapie (SRT)},
       journal = {Zeitschrift für Medizinische Physik},
       volume = {17},
       number = {1},
       pages = {6-22},
       abstract = {Zusammenfassung Die am Medizinischen Laserzentrum Lübeck entwickelte selektive Retina-Therapie (SRT) wird zur Zeit als neue, schonende Laser-Behandlungsmethode für verschiedene Erkrankungen des Augenhintergrunds evaluiert, deren Ursachen einer Degradation des Retinalen Pigmentepithels (RPE) zugeschrieben werden. Mit der SRT lässt sich selektiv das RPE behandeln, ohne die angrenzende neurosensorische Netzhaut mit den Photorezeptoren und die unter dem RPE liegende Aderhaut (Choroidea) zu beeinträchtigen. Die Therapie führt idealerweise zu einer Regeneration des RPEs und einem gesteigerten Metabolismus am chorio-retinalen Übergang. Im Gegensatz zur etablierten Laserphotokoagulation, bei der die Netzhaut in und um die bestrahlten Areale komplett verödet wird, bleibt bei der SRT die Sehfähigkeit der Patienten in den bestrahlten Arealen erhalten. Der Artikel gibt einen Überblick über die Idee und die physikalischen Mechanismen selektiver RPE-Behandlung, die online Dosimetrie der optisch nicht sichtbaren Effekte und fasst die ersten klinischen Ergebnisse zusammen. Selective Retina Therapy (SRT) is a new and very gentle laser method developed at the Medical Laser Center Lübeck. It is currently investigated clinically in order to treat retinal disorders associated with a decreased function of the retinal pigment epithelium (RPE). SRT is designed to selectively effect the RPE while sparing the neural retina and the photoreceptors as well as the chorioidea. Aim of the therapy is the rejuvenation of the RPE in the treated areas, which should ideally lead to a long term metabolic increase at the chorio-retinal junction. In contrast to conventional laser photocoagulation, which is associated with a complete thermal necrosis of the treated site, SRT completely retains full vision. This paper reviews the methods and mechanisms behind selective RPE effects and reports the first clinical results. An online dosimetry technique to visualize the ophthalmoscopically invisible effects is introduced.},
       keywords = {Selektive Zelleffekte, Optoakustik, Mikroblasen, Online-Dosimetrie, RPE, ?s-Laserpulse, Makulaödeme, RCS
    Selective cellular effects, optoacoustics, online dosimetry, RPE, ?s-laser pulses, macula oedema, RCS},
       year = {2006}
    }
  • Elsner, H. and Klatt, C. and Liew, S. H. and Porksen, E. and Bunse, A. and Rudolf, M. and Brinkmann, R. and Hamilton, R. P. and Birngruber, R. and Laqua, H. and Roider, J.: Selektive Retina Therapiey (SRT) bei Patienten mit diabetischer Makulopathie. Ophthalmologe, no. 103, pp. 856-860, 2006
    BibTeX
    @article{Elsner2006,
       author = {Elsner, H. and Klatt, C. and Liew, S. H. and Porksen, E. and Bunse, A. and Rudolf, M. and Brinkmann, R. and Hamilton, R. P. and Birngruber, R. and Laqua, H. and Roider, J.},
       title = {Selektive Retina Therapiey (SRT) bei Patienten mit diabetischer Makulopathie},
       journal = {Ophthalmologe},
       volume = {103},
       number = {10},
       pages = {856-860},
       note = {0941-293X (Print)
    Journal article},
       abstract = {Selective Retina Therapy (SRT) is a new laser treatment that selectively targets the retinal pigmen epithelium (RPE). In this study, we treated 39 patients presenting with nonischemic, focal and focal-diffuse diabetic maculopathy with SRT. In the main. the results indicate that SRT had stabilizing effects on visual acuity, angiographic leakage, lipid exudation, and foveal retinal thickness. SRT is safe and is especially useful for treating pathologies that are located close to the fovea, which cannot be treated with conventional argon laser photocoagulation.},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16937095},
       year = {2006},
       type = {Journal Article}
    }
    
  • Roider, J.: Selektive Retina Therapie – SRT. Der Ophthalmologe, no. 103, pp. 837-838, 2006
    BibTeX
    @article{Roider,
       author = {Roider, J.},
       title = {Selektive Retina Therapie – SRT},
       journal = {Der Ophthalmologe},
       volume = {103},
       number = {10},
       pages = {837-838},
       year = {2006}
    }
  • Brinkmann, R and Schuele, G. and Neumann, J. and Framme, C. and Pörkensen, E. and Elsner, H. and Theisen-Kunde, D and Roider, J. and Birngruber, R.: Selektive Retina Therapie - Methodik, Technik und Online-Dosimetrie. Ophthalmologe, no. 103, pp. 839-849, 2006
    BibTeX
    @article{Brinkmann,
       author = {Brinkmann, R and Schuele, G. and Neumann, J. and Framme, C. and Pörkensen, E. and Elsner, H. and Theisen-Kunde, D and Roider, J. and Birngruber, R.},
       title = {Selektive Retina Therapie - Methodik, Technik und Online-Dosimetrie},
       journal = {Ophthalmologe},
       volume = {103},
       pages = {839-849},
       year = {2006}
    }
  • Klatt, C. and Elsner, H. and Porksen, E. and Brinkmann, R. and Bunse, A. and Birngruber, R. and Roider, J.: Selective retina therapy in central serous chorioretinopathy with detachment of the pigmentary epithelium. Ophthalmologe, no. 103, pp. 850-5, 2006
    BibTeX Link
    @article{Klatt2006,
       author = {Klatt, C. and Elsner, H. and Porksen, E. and Brinkmann, R. and Bunse, A. and Birngruber, R. and Roider, J.},
       title = {Selective retina therapy in central serous chorioretinopathy with detachment of the pigmentary epithelium},
       journal = {Ophthalmologe},
       volume = {103},
       number = {10},
       pages = {850-5},
       note = {0941-293X (Print)
    Case Reports
    English Abstract
    Journal Article},
       abstract = {BACKGROUND: Selective Retina Therapy (SRT) is a new and innovative laser treatment modality that selectively treats the retinal pigmentary epithelium while sparing the photoreceptors. This therapeutic concept appears to be particularly suitable for treating patients with acute or chronic central serous chorioretinopathy (CSC). We present preliminary results obtained in five patients who had CSC associated with pigmentary epithelium detachment (PED) and serous subretinal fluid (SRF) and who were treated with SRT. METHODS: This case series was made up of five male patients (mean age 47 years) with chronic CSC and SRF resulting from PED. Examinations performed before and at 1 month and 3 months after the treatment were: BCVA, FLA, OCT (Zeiss OCT III). For SRT, confluent treatment of the PED (area of leakage) was carried out using a pulsed frequency-doubled, Q-switched Nd-YLF prototype laser (lambda=527 nm, t= 1.7 s, 100 Hz, energy = 150-250 J). RESULTS: Best corrected visual acuity at baseline was 0.53, while after 4 weeks it was 0.56 and after 12 weeks, 0.5. At baseline leakage was seen at the PED on fluorescein angiography in all patients. After 4 weeks leakage activity was no longer noted on angiography in 4 of 5 patients. OCT at baseline showed SRF at the edge of the PED in all patients, but in 4 of the 5 patients this was no longer detectable after 4 weeks. CONCLUSION: SRT is a safe and effective treatment for patients with CSC in which PED has caused SRF. Not a single case of rip syndrome was observed in this study, even though the PED was treated confluently. Since SRT spares the photoreceptors it is particularly suitable for the treatment of CSC, especially when the origin of leakage is located close to the fovea. The results indicate that SRT leads to reconstruction of the outer blood-retina barrier.},
       keywords = {Adult
    Chorioretinitis/complications/*surgery
    Humans
    Laser Surgery/*methods
    Lasers/*therapeutic use
    Male
    Middle Aged
    Ophthalmologic Surgical Procedures/*methods
    Preoperative Care/methods
    Retinal Detachment/etiology/*surgery
    Treatment Outcome},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16937094},
       year = {2006},
       type = {Journal Article}
    }
    
  • Brinkmann, R. and Roider, J. and Birngruber, R.: Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results. Bull Soc Belge Ophtalmol, pp. 51-69, 2006
    BibTeX
    @article{Brinkmann,
       author = {Brinkmann, R. and Roider, J. and Birngruber, R.},
       title = {Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results},
       journal = {Bull Soc Belge Ophtalmol},
       number = {302},
       pages = {51-69},
       note = {0081-0746 (Print)
    Journal Article
    Review},
       abstract = {Selective retina therapy (SRT) is a new laser procedure for retinal diseases that are thought to be associated with a degradation of the retinal pigment epithelium (RPE). The aim of the irradiation is to selectively damage the RPE without affecting the neural retina, the photoreceptors and the choroid. Goal of the treatment is to stimulate RPE cell migration and proliferation into the irradiated areas in order to improve the metabolism at the diseased retinal sites. In a pilot study more than 150 patients with soft drusen, retinopathia centralis serosa (RCS) and macular edema were treated. The first 3-center international trial targets diabetic macular edema and branch vein occlusion. In this review, selective RPE effects are motivated and two modalities to achieve selective RPE effects will be introduced: a pulsed and a continuous wave scanning mode. The mechanism behind selective RPE-effects will be discussed reviewing in vitro results and temperature calculations. So far clinical SRT is performed by applying trains of 30 laser pulses from a Nd:YLF-Laser (527 nm, 1.7 micros, 100 Hz) to the diseased fundus areas. In the range of 450-800 mJ/cm(2) per pulse, RPE-defects in patients were proved angiographically by fluorescein or ICG-leakage. The selectivity with respect to surrounding highly sensitive tissue and the safety range of the treatment will be reviewed. With the laser parameters used neither bleeding nor scotoma, proved by microperimetry, were observed thus demonstrating no adverse effects to the choroid and the photoreceptors, respectively. During and after irradiation, it shows that the irradiated locations are ophthalmoscopically invisible, since the effects are very limited and confined to the RPE, thus a dosimetry control is demanded. We report on a non-invasive opto-acoustic on-line technique to monitor successful RPE-irradiation and compare the data to those achieved with standard angiography one-hour post treatment.},
       keywords = {Fluorescein Angiography
    Humans
    Laser Coagulation/adverse effects/*methods
    Multicenter Studies
    Perimetry
    Pigment Epithelium of Eye/pathology/surgery
    Retinal Diseases/diagnosis/pathology/*surgery
    Scotoma/etiology/prevention & control},
       year = {2006}
    }
  • Brinkmann, R. and Roider, J. and Birngruber, R.: Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results. Bull Soc Belge Ophtalmol, pp. 51-69, 2006
    BibTeX
    @article{Brinkmann,
       author = {Brinkmann, R. and Roider, J. and Birngruber, R.},
       title = {Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results},
       journal = {Bull Soc Belge Ophtalmol},
       number = {302},
       pages = {51-69},
       note = {0081-0746 (Print)
    Journal Article
    Review},
       abstract = {Selective retina therapy (SRT) is a new laser procedure for retinal diseases that are thought to be associated with a degradation of the retinal pigment epithelium (RPE). The aim of the irradiation is to selectively damage the RPE without affecting the neural retina, the photoreceptors and the choroid. Goal of the treatment is to stimulate RPE cell migration and proliferation into the irradiated areas in order to improve the metabolism at the diseased retinal sites. In a pilot study more than 150 patients with soft drusen, retinopathia centralis serosa (RCS) and macular edema were treated. The first 3-center international trial targets diabetic macular edema and branch vein occlusion. In this review, selective RPE effects are motivated and two modalities to achieve selective RPE effects will be introduced: a pulsed and a continuous wave scanning mode. The mechanism behind selective RPE-effects will be discussed reviewing in vitro results and temperature calculations. So far clinical SRT is performed by applying trains of 30 laser pulses from a Nd:YLF-Laser (527 nm, 1.7 micros, 100 Hz) to the diseased fundus areas. In the range of 450-800 mJ/cm(2) per pulse, RPE-defects in patients were proved angiographically by fluorescein or ICG-leakage. The selectivity with respect to surrounding highly sensitive tissue and the safety range of the treatment will be reviewed. With the laser parameters used neither bleeding nor scotoma, proved by microperimetry, were observed thus demonstrating no adverse effects to the choroid and the photoreceptors, respectively. During and after irradiation, it shows that the irradiated locations are ophthalmoscopically invisible, since the effects are very limited and confined to the RPE, thus a dosimetry control is demanded. We report on a non-invasive opto-acoustic on-line technique to monitor successful RPE-irradiation and compare the data to those achieved with standard angiography one-hour post treatment.},
       keywords = {Fluorescein Angiography
    Humans
    Laser Coagulation/adverse effects/*methods
    Multicenter Studies
    Perimetry
    Pigment Epithelium of Eye/pathology/surgery
    Retinal Diseases/diagnosis/pathology/*surgery
    Scotoma/etiology/prevention & control},
       year = {2006}
    }
  • Elsner, H and Pörksen, E and Klatt, C and Bunse, A and Theisen-Kunde, D and Brinkmann, R and Birngruber, R and Laqua, H and Roider, J: Selective Retina Therapy (SRT) in patients with central serous chorioretinopathy (CSC). Graefes Arch Ophthalmol, in print., no. on-line: DOI 10.1007/s00417-006-0368-5, 2006
    BibTeX
    @article{Elsner2006,
       author = {Elsner, H and Pörksen, E and Klatt, C and Bunse, A and Theisen-Kunde, D and Brinkmann, R and Birngruber, R and Laqua, H and Roider, J},
       title = {Selective Retina Therapy (SRT) in patients with central serous chorioretinopathy (CSC)},
       journal = {Graefes Arch Ophthalmol, in print.},
       volume = {on-line: DOI 10.1007/s00417-006-0368-5},
       year = {2006},
       type = {Journal Article}
    }
    
  • Elsner, H and Pörksen, E and Klatt, C and Bunse, A and Theisen-Kunde, D and Brinkmann, R and Birngruber, R and Laqua, H and Roider, J: Selective Retina Therapy (SRT) in patients with central serous chorioretinopathy (CSC). Graefes Arch Ophthalmol, in print., no. on-line: DOI 10.1007/s00417-006-0368-5, 2006
    BibTeX
    @article{Elsner,
       author = {Elsner, H and Pörksen, E and Klatt, C and Bunse, A and Theisen-Kunde, D and Brinkmann, R and Birngruber, R and Laqua, H and Roider, J},
       title = {Selective Retina Therapy (SRT) in patients with central serous chorioretinopathy (CSC)},
       journal = {Graefes Arch Ophthalmol, in print.},
       volume = {on-line: DOI 10.1007/s00417-006-0368-5},
       year = {2006}
    }
  • Tamaoki, S and Hayashi, Y and Sakaguchi, H and Tanaka, N and Ota, M and Yokoyama, T and Shiraki, K: Retinoblastoma in the patient with 13q-syndrome: a report of two cases.. Japanese Review of Clinical Ophthalmology, no. 100, pp. 587-590, 2006
    BibTeX
    @article{Hayashi,
       author = {Tamaoki, S and Hayashi, Y and Sakaguchi, H and Tanaka, N and Ota, M and Yokoyama, T and Shiraki, K},
       title = {Retinoblastoma in the patient with 13q-syndrome: a report of two cases.},
       journal = {Japanese Review of Clinical Ophthalmology},
       volume = {100},
       number = {8},
       pages = {587-590},
       year = {2006}
    }
    
  • Tanaka, R and Hayashi, Y and Kohno, T and Yamazaki, K and Shiraki, K: Retinal phlebitis in a case of erythema induratum of Bazin. Japanese Journal of Clinical Ophthalmology, no. 60, pp. 1901-1904, 2006
    BibTeX
    @article{Hayashi,
       author = {Tanaka, R and Hayashi, Y and Kohno, T and Yamazaki, K and Shiraki, K},
       title = {Retinal phlebitis in a case of erythema induratum of Bazin},
       journal = {Japanese Journal of Clinical Ophthalmology},
       volume = {60},
       number = {12},
       pages = {1901-1904},
       abstract = {Purpose?To report a case of erythema of Bazin associated with retinal phlebitis. Case and Findings?A 59-year-old woman developed painful exanthema in both legs,followed by blurring and seeing flies in her left eye one month later. She was strongly positive to tuberculin test. Biopsy of erythema showed epithelioid granuloma with Langhans giant cells,leading to the diagnosis of Bazin disease. When seen 6 weeks after onset of blurring,her corrected visual acuity was 1.2 right and 1.0 left. Her left eye showed signs of retinal phlebitis. Peroral corticosteroid failed to improve skin and fundus lesions. Similar retinal phlebitis developed in the right eye 2 months later. Pulsed corticosteroid followed by tapering was followed by gradual improvement of skin and eye manifestations. Conclusion?Pulsed corticosteroid therapy may be effective for skin and eye manifestations of erythema of Bazin.},
       year = {2006}
    }
    
  • Diddens, H. and Arp, N. and Eisenbeiß, W.: Photodynamische Therapie zur Behandlung lokaler Wunden. GMS Krankenhaushyg Interdiszip, no. 1, pp. Doc 19, 2006
    BibTeX
    @article{Diddens,
       author = {Diddens, H. and Arp, N. and Eisenbeiß, W.},
       title = {Photodynamische Therapie zur Behandlung lokaler Wunden},
       journal = {GMS Krankenhaushyg Interdiszip},
       volume = {1},
       number = {1},
       pages = {Doc 19},
       year = {2006}
    }
  • Hoerauf, H. and Brix, A. and Winkler, J. and Droege, G. and Winter, C. and Birngruber, R. and Laqua, H. and Vogel, A.: Photoablation of inner limiting membrane and inner retinal layers using the erbium : YAG-laser: An in vitro study. Lasers in Surgery and Medicine, no. 38, pp. 52-61, 2006
    BibTeX Link
    @article{Hoerauf2006,
       author = {Hoerauf, H. and Brix, A. and Winkler, J. and Droege, G. and Winter, C. and Birngruber, R. and Laqua, H. and Vogel, A.},
       title = {Photoablation of inner limiting membrane and inner retinal layers using the erbium : YAG-laser: An in vitro study},
       journal = {Lasers in Surgery and Medicine},
       volume = {38},
       number = {1},
       pages = {52-61},
       note = {009YN
    Times Cited:4
    Cited References Count:51},
       abstract = {Background and Objectives: To explore the potential of Er:YAG-laser irradiation for precise and tractionless retinal tissue and inner limiting membrane ablation.
    Materials and Methods: We used free-running Er:YAG-laser irradiation (lambda = 2.94 mu m) transmitted either through a 10 em long low-OH-quartz fiber or a 2 m long sapphire fiber that produced a more homogenous light distribution at the fiber tip. Retinal ablation in porcine retinal explants was performed under air or perfluorodecaline (PFD). Ablation depth was evaluated by optical coherence tomography (OCT) and from histologic sections.
    Results: A radiant exposure of 5.0 J/cm(2) delivered through a low-OH-quartz fiber and PFD caused a complete transsection of the neurosensory retina. Radiant exposures between 3.5 and 2.0 J/cm(2) resulted in marked variations of ablation depth and adjacent thermal damage. By contrast, laser pulses of 4.0 and 3.0 J/cm(2) transmitted through the sapphire fiber produced more homogenous defect patterns and less thermal damage. Close to the ablation threshold, with 1.0-2.0 J/cm(2), ablation was limited to a 10-20 mu m thin layer of the neural retina.
    Conclusions: We achieved in vitro ablation of inner retinal layers, but could not produce selective and reproducible ILM removal.},
       keywords = {macular surgery
    optical coherence tomography
    perfluorocarbon liquid
    retina
    retinal explant
    optical coherence tomography
    macular hole surgery
    experimental vitreous membranes
    er-yag
    vitreoretinal surgery
    clinical-experience
    indocyanine green
    excimer-laser
    pig eyes
    ablation},
       ISSN = {0196-8092},
       DOI = {Doi 10.1002/Lsm.20269},
       url = {<Go to ISI>://WOS:000235149600007},
       year = {2006},
       type = {Journal Article}
    }
    
  • Kandulla, J. and Elsner, H. and Birngruber, R. and Brinkmann, R.: Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation. Journal of Biomedical Optics, no. 11, 2006
    BibTeX Link
    @article{Kandulla2006,
       author = {Kandulla, J. and Elsner, H. and Birngruber, R. and Brinkmann, R.},
       title = {Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation},
       journal = {Journal of Biomedical Optics},
       volume = {11},
       number = {4},
       note = {093IM
    Times Cited:30
    Cited References Count:40},
       abstract = {The therapeutic effect of most retinal laser treatments is initiated by a transient temperature increase. Although crucial to the effectiveness of the treatment, the temperature course is not exactly known due to individually different tissue properties. We develop an optoacoustic method to determine the retinal temperature increase in real time during continuous-wave (cw) laser irradiation, and perform temperature calculations to interpret the results exemplary for transpupillary thermotherapy (TTT). Porcine globes ex vivo and rabbit eyes in vivo are irradiated with a diode laser (lambda=810 nm, P <= 3 W, phi = 2 mm) for 60 s. Simultaneously, pulses from a N-2-laser pumped dye laser (lambda= 500 nm, tau= 3.5 ns, E approximate to 5 mu J) are applied on the retina. Following its absorption, an ultrasonic pressure wave is emitted, which is detected by a transducer embedded in a contact lens. Using the previously measured temperature-dependent Gruneisen coefficient of chorioretinal tissue, a temperature raise in porcine eyes of 5.8 degrees C/ (W/cm(2)) after 60 s is observed and confirmed by simultaneous measurements with an inserted thermocouple. In a rabbit, we find 1.4 degrees C/(W/cm(2)) with, and 2.2 degrees C/(W/cm(2)) without perfusion at the same location. Coagulation of the rabbit's retina occurs at Delta T = 21 degrees C after 40 s. In conclusion, this optoacoustic method seems feasible for an in vivo real-time determination of temperature, opening the possibility for feedback control retinal laser treatments. (c) 2006 Society of Photo-Optical Instrumentation Engineers.},
       keywords = {temperature
    optoacoustics
    transpupillary thermotherapy
    ultrasonic transducer
    laser
    heat diffusion calculations
    retinal laser treatment
    subfoveal choroidal neovascularization
    transpupillary thermotherapy
    macular degeneration
    ocular media
    blood flow
    eye
    fundus
    light
    photocoagulation
    transmission},
       ISSN = {1083-3668},
       DOI = {Artn 041111
    Doi 10.1117/1.2236301},
       url = {<Go to ISI>://WOS:000241162000016},
       year = {2006},
       type = {Journal Article}
    }
    
  • Kandulla, J. and Elsner, H. and Birngruber, R. and Brinkmann, R.: Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation. J Biomed Opt, no. 11, pp. 041111, 2006
    BibTeX
    @article{Kandulla,
       author = {Kandulla, J. and Elsner, H. and Birngruber, R. and Brinkmann, R.},
       title = {Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation},
       journal = {J Biomed Opt},
       volume = {11},
       number = {4},
       pages = {041111},
       note = {1083-3668 (Print)
    In Vitro
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {The therapeutic effect of most retinal laser treatments is initiated by a transient temperature increase. Although crucial to the effectiveness of the treatment, the temperature course is not exactly known due to individually different tissue properties. We develop an optoacoustic method to determine the retinal temperature increase in real time during continuous-wave (cw) laser irradiation, and perform temperature calculations to interpret the results exemplary for transpupillary thermotherapy (TTT). Porcine globes ex vivo and rabbit eyes in vivo are irradiated with a diode laser (lambda=810 nm, P< or =3 W, phi=2 mm) for 60 s. Simultaneously, pulses from a N2-laser pumped dye laser (lambda=500 nm, tau=3.5 ns, E approximately 5 microJ) are applied on the retina. Following its absorption, an ultrasonic pressure wave is emitted, which is detected by a transducer embedded in a contact lens. Using the previously measured temperature-dependent Gruneisen coefficient of chorioretinal tissue, a temperature raise in porcine eyes of 5.8 degrees C(Wcm2) after 60 s is observed and confirmed by simultaneous measurements with an inserted thermocouple. In a rabbit, we find 1.4 degrees C(Wcm2) with, and 2.2 degrees C(Wcm2) without perfusion at the same location. Coagulation of the rabbit's retina occurs at DeltaT=21 degrees C after 40 s. In conclusion, this optoacoustic method seems feasible for an in vivo real-time determination of temperature, opening the possibility for feedback control retinal laser treatments.},
       keywords = {Animals
    Body Temperature/physiology/radiation effects
    Equipment Design
    Equipment Failure Analysis
    Feasibility Studies
    Hyperthermia, Induced/*instrumentation
    Lasers/*therapeutic use
    Online Systems
    Rabbits
    Reproducibility of Results
    Retina/*physiology/*radiation effects/ultrasonography
    Sensitivity and Specificity
    Swine
    Thermography/*instrumentation/methods
    Ultrasonography/*instrumentation/methods},
       year = {2006}
    }
  • Giese, A. and Böhringer, H.J. and Leppert, J. and Kandelhardt, S.R. and Lankenau, E. and Koch, P. and Birngruber, R. and Hüttmann, G.: Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors.. Proc SPIE, no. 6078, pp. 495-502, 2006
    BibTeX
    @article{Giese2006,
       author = {Giese, A. and Böhringer, H.J. and Leppert, J. and Kandelhardt, S.R. and Lankenau, E. and Koch, P. and Birngruber, R. and Hüttmann, G.},
       title = {Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors.},
       journal = {Proc SPIE},
       volume = {6078},
       pages = {495-502},
       year = {2006},
       type = {Journal Article}
    }
    
  • Giese, A. and Böhringer, H.J. and Leppert, J. and Kandelhardt, S.R. and Lankenau, E. and Koch, P. and Birngruber, R. and Hüttmann, G.: Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors.. Proc SPIE, no. 6078, pp. 495-502, 2006
    BibTeX
    @article{Giese,
       author = {Giese, A. and Böhringer, H.J. and Leppert, J. and Kandelhardt, S.R. and Lankenau, E. and Koch, P. and Birngruber, R. and Hüttmann, G.},
       title = {Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors.},
       journal = {Proc SPIE},
       volume = {6078},
       pages = {495-502},
       year = {2006}
    }
  • Giese, A. and Böhringer, H.J. and Leppert, J. and Kandelhardt, S.R. and Lankenau, E. and Koch, P. and Birngruber, R. and Hüttmann, G.: Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors.. Proc SPIE, no. 6078, pp. 495-502, 2006
    BibTeX
    @article{Giese,
       author = {Giese, A. and Böhringer, H.J. and Leppert, J. and Kandelhardt, S.R. and Lankenau, E. and Koch, P. and Birngruber, R. and Hüttmann, G.},
       title = {Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors.},
       journal = {Proc SPIE},
       volume = {6078},
       pages = {495-502},
       year = {2006}
    }
  • Kranendonk, Laura A and Walewski, Joachim W and Sanders, Scott T and Huber, Robert and Fujimoto, James G: Measurements of Gas Temperature in an HCCI Engine by Use of a Fourier-Domain Mode-Locking Laser. in Laser Applilcations to Chemical, Security and Environmental Analysis, pp. TuB2 1-2, OSA, Washington, D.C., 2006
    BibTeX Link
    @InProceedings{HU_2006_Kranendonk_b,
      Title                    = {{Measurements of Gas Temperature in an HCCI Engine by Use of a Fourier-Domain Mode-Locking Laser}},
      Author                   = {Kranendonk, Laura A and Walewski, Joachim W and Sanders, Scott T and Huber, Robert and Fujimoto, James G},
      Booktitle                = {Laser Applilcations to Chemical, Security and Environmental Analysis},
      Year                     = {2006},
    
      Address                  = {Washington, D.C.},
      Pages                    = {TuB2 1--2 },
      Publisher                = {OSA},
    
      Doi                      = {10.1364/LACSEA.2006.TuB2},
      ISBN                     = {1-55752-799-7},
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?URI=LACSEA-2006-TuB2}
    }
  • Kranendonk, Laura A and Walewski, Joachim W and Sanders, Scott T and Huber, Robert and Fujimoto, James G: Measurements of Gas Temperature in a HCCI Engine Using a Fourier Domain Mode Locking Laser. pp. 1366 1-5, apr,, 2006
    BibTeX Link
    @TechReport{HU_2006_Kranendonk_a,
      Title                    = {{Measurements of Gas Temperature in a HCCI Engine Using a Fourier Domain Mode Locking Laser}},
      Author                   = {Kranendonk, Laura A and Walewski, Joachim W and Sanders, Scott T and Huber, Robert and Fujimoto, James G},
      Year                     = {2006},
      Month                    = apr,
      pages  = {1366 1--5}
    
      Doi                      = {10.4271/2006-01-1366},
      Url                      = {http://www.sae.org/technical/papers/2006-01-1366}
    }
  • Yamamoto, M and Kohno, T and Murasawa, M and Ono, H and Ueda, S and Hayashi, Y and Ataka, S and Shiraki, K: Lipofuscin autofluorescence in a case of crystalline retinopathy.. Japanese Journal of Clinical Ophthalmology, no. 60, pp. 1039-1043, 2006
    BibTeX
    @article{Hayashi,
       author = {Yamamoto, M and Kohno, T and Murasawa, M and Ono, H and Ueda, S and Hayashi, Y and Ataka, S and Shiraki, K},
       title = {Lipofuscin autofluorescence in a case of crystalline retinopathy.},
       journal = {Japanese Journal of Clinical Ophthalmology},
       volume = {60},
       number = {6},
       pages = {1039-1043},
       year = {2006}
    }
    
  • Huber, R and Taira, K and Wojtkowski, M and Fujimoto, J G: Fourier domain mode-locked lasers for swept source OCT imaging at up to 290 kHz scan rates. in Proceedings of SPIE, no. 6079, pp. 60790U-60790U-6, feb,, 2006
    BibTeX Link
    @InProceedings{HU_2006_Huber_a,
      Title                    = {{Fourier domain mode-locked lasers for swept source OCT imaging at up to 290 kHz scan rates}},
      Author                   = {Huber, R and Taira, K and Wojtkowski, M and Fujimoto, J G},
      Booktitle                = {Proceedings of SPIE},
      Year                     = {2006},
      Editor                   = {Tuchin, Valery V. and Izatt, Joseph A. and Fujimoto, James G.},
      Month                    = feb,
      Pages                    = {60790U--60790U--6},
      Volume                   = {6079},
    
      Doi                      = {10.1117/12.648880},
      Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1273744}
    }
  • Huber, R and Wojtkowski, M and Fujimoto, J G: Fourier domain mode locking (FDML): Three-dimensional OCT imaging at 906 frames per second. in Conference on Lasers and Electro-Optics and 2006 Quantum Electronics and Laser Science Conference, CLEO/QELS 2006, 2006
    BibTeX Link
    @InProceedings{HU_2006_Huber_d,
      Title                    = {{Fourier domain mode locking (FDML): Three-dimensional OCT imaging at 906 frames per second}},
      Author                   = {Huber, R and Wojtkowski, M and Fujimoto, J G},
      Booktitle                = {Conference on Lasers and Electro-Optics and 2006 Quantum Electronics and Laser Science Conference, CLEO/QELS 2006},
      Year                     = {2006},
    
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?uri=CLEO-2006-CMZ2}
    }
  • Huber, R and Wojtkowski, M and Fujimoto, J G: Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography. Optics Express, no. 14, pp. 3225 - 3237, apr,, 2006
    BibTeX Link
    @Article{HU_2006_Huber_c,
      Title                    = {{Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography}},
      Author                   = {Huber, R and Wojtkowski, M and Fujimoto, J G},
      Journal                  = {Optics Express},
      Year                     = {2006},
    
      Month                    = apr,
      Number                   = {8},
      Pages                    = {3225 -- 3237 },
      Volume                   = {14},
    
      Doi                      = {10.1364/OE.14.003225},
      ISSN                     = {1094-4087},
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?URI=oe-14-8-3225}
    }
  • Lenz, Martin O and Huber, Robert and Schmidt, Bernhard and Gilch, Peter and Kalmbach, Rolf and Engelhard, Martin and Wachtveitl, Josef: First steps of retinal photoisomerization in proteorhodopsin. Biophysical journal, no. 91, pp. 255-62, jul,, 2006
    BibTeX Link
    @Article{HU_2006_Lenz_a,
      Title                    = {{First steps of retinal photoisomerization in proteorhodopsin}},
      Author                   = {Lenz, Martin O and Huber, Robert and Schmidt, Bernhard and Gilch, Peter and Kalmbach, Rolf and Engelhard, Martin and Wachtveitl, Josef},
      Journal                  = {Biophysical journal},
      Year                     = {2006},
    
      Month                    = jul,
      Number                   = {1},
      Pages                    = {255--62},
      Volume                   = {91},
    
      Doi                      = {10.1529/biophysj.105.074690},
      Institution              = {Institut f\"{u}r Physikalische und Theoretische Chemie, Johann-Wolfgang-Goethe-Universit\"{a}t, Frankfurt, Germany.},
      ISSN                     = {0006-3495},
      Url                      = {http://www.cell.com/biophysj/abstract/S0006-3495\%2806\%2971725-8}
    }
  • Muller, M. and Hoerauf, H. and Geerling, G. and Pape, S. and Winter, C. and Hüttmann, G. and Birngruber, R. and Laqua, H.: Filtring Bleb Evaluation with Slit-Lamp-Adapted 1310-nm Optical Coherence Tomography. Curr Eye Res, no. 31, pp. 909-915, 2006
    BibTeX
    @article{Müller2006,
       author = {Muller, M. and Hoerauf, H. and Geerling, G. and Pape, S. and Winter, C. and Hüttmann, G. and Birngruber, R. and Laqua, H.},
       title = {Filtring Bleb Evaluation with Slit-Lamp-Adapted 1310-nm Optical Coherence Tomography},
       journal = {Curr Eye Res},
       volume = {31},
       number = {11},
       pages = {909-915},
       year = {2006},
       type = {Journal Article}
    }
    
  • Muller, M. and Hoerauf, H. and Geerling, G. and Pape, S. and Winter, C. and Huttmann, G. and Birngruber, R. and Laqua, H.: Filtering bleb evaluation with slit-lamp-adapted 1310-nm optical coherence tomography. Current Eye Research, no. 31, pp. 909-915, 2006
    BibTeX Link
    @article{Müller2006,
       author = {Muller, M. and Hoerauf, H. and Geerling, G. and Pape, S. and Winter, C. and Huttmann, G. and Birngruber, R. and Laqua, H.},
       title = {Filtering bleb evaluation with slit-lamp-adapted 1310-nm optical coherence tomography},
       journal = {Current Eye Research},
       volume = {31},
       number = {11},
       pages = {909-915},
       note = {107AB
    Times Cited:24
    Cited References Count:27},
       abstract = {Purpose: Investigation of slit-lamp-adapted 1310-nm optical coherence tomography (OCT) as an in vivo imaging device in the postoperative course of glaucoma surgery. Methods: Postoperative images of filtering blebs and deep sclerectomies and their healing processes were qualitatively evaluated with a slit-lamp-adapted anterior segment OCT (AS-OCT; Heidelberg Engineering, Heidelberg, Germany) in 28 patients. Ophthalmologic examinations included slit-lamp examination, applanation tonometry, and slit-lamp photography. The OCT scans were qualitatively correlated with the morphologic and functional outcome of the filtering bleb. Results: 1310-nm OCT was able to demonstrate the internal structure and the dimensions of filtering blebs, as well as the scleral flap and the deep sclerectomy location including Descemet membrane. Functioning filtering blebs showed a low OCT signal, small fluid-filled cysts, superficial microcystic layer, and a slack internal texture. High internal reflectivity indicated an earlier scarring of the filtering bleb. Nonfunctioning filtering blebs delivered a high OCT signal, no or few cysts, and a dense internal texture. These different OCT patterns correlated with the clinical outcome. Conclusions: Slit-lamp-adapted 1310-nm OCT allowed the noncontact observation and documentation of the postoperative healing course of filtering blebs after glaucoma surgery. Internal structures of the filtering bleb and deep sclerectomies could be visualized. Functioning and dysfunctioning filtering blebs delivered different OCT pattern and correlated with the clinical outcome. This could be a new way to assess the postoperative healing process with the possibility of earlier intervention in cases of impending scarring.},
       keywords = {deep sclerectomy
    filtering bleb
    oct
    scarring
    anterior segment
    mitomycin-c
    follow-up
    trabeculectomy
    surgery
    cornea
    eye},
       ISSN = {0271-3683},
       DOI = {Doi 10.1080/02713680600910528},
       url = {<Go to ISI>://WOS:000242142000003},
       year = {2006},
       type = {Journal Article}
    }
    
  • Vogel, A. and Noack, J and Hüttmann, G. and Paltauf, G.: Femtosecond plasma-mediated nanosurgery of cells and tissues.. in Laser Ablation, pp. 217-262, Springer, Heidelberg, 2006
    BibTeX
    @inbook{Vogel2006,
       author = {Vogel, A. and Noack, J and Hüttmann, G. and Paltauf, G.},
       title = {Femtosecond plasma-mediated nanosurgery of cells and tissues.},
       booktitle = {Laser Ablation},
       editor = {), Phipps C (Hrsg.},
       publisher = { Springer, Heidelberg},
       pages = {217-262},
       year = {2006}
    }
  • Framme, C. and Sachs, H. G. and Flucke, B. and Theisen-Kunde, D. and Birngruber, R.: Evaluation of the new photosensitizer Tookad (WST09) for photodynamic vessel occlusion of the choroidal tissue in rabbits. Invest Ophthalmol Vis Sci, no. 47, pp. 5437-46, 2006
    BibTeX Link
    @article{Framme2006,
       author = {Framme, C. and Sachs, H. G. and Flucke, B. and Theisen-Kunde, D. and Birngruber, R.},
       title = {Evaluation of the new photosensitizer Tookad (WST09) for photodynamic vessel occlusion of the choroidal tissue in rabbits},
       journal = {Invest Ophthalmol Vis Sci},
       volume = {47},
       number = {12},
       pages = {5437-46},
       note = {0146-0404 (Print)
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {PURPOSE: To determine the efficacy of Tookad (WST09; Negma-Lerads, Magny-Les-Hameaux, France) photodynamic therapy (T-PDT) by evaluating the angiographic and histologic closure of choroidal vessels at different radiance exposures, drug dosages, and intervals between photosensitizer injection and laser application in a rabbit model. METHODS: Chinchilla Bastard rabbits were injected intravenously with three different dye concentrations (2.5, 5, and 10 mg/kg) before application of light. In every group T-PDT was performed at four different times after injection: 5, 15, 30, and 60 minutes with different radiance exposures ranging from 200 to 3 J/cm2. Fundus photographs and fluorescein angiograms were obtained 90 minutes after injection. Follow-up angiographies were performed at days 1, 3, 7, and 14 after initial treatment. Histology was performed in selected cases immediately after treatment and on days 1, 3, and 7. RESULTS: Immediately after irradiation, most of the visible lesions were angiographically hyperfluorescent due to damaged vessel endothelium and associated RPE damage. Lesions from high-radiance exposures revealed immediate hypofluorescence, indicating vessel closure. Hypofluorescent lesions appeared mainly during day 1 (all lesions angiographically visible, some hypofluorescent) to day 3 (all lesions hypofluorescent) after treatment. At day 7, ophthalmoscopically visible hyperpigmentation took place in all lesions. ED50 thresholds for angiographic hypofluorescence determined at day 3 after treatment with 2.5 mg/kg were 18.8 J/cm2 (5 minutes), 62.0 J/cm2 (15 minutes), and >100 J/cm2 (30 minutes); with 5 mg/kg, 8.4 J/cm2 (5 minutes), 22.8 J/cm2 (15 minutes), 54.5 J/cm2 (30 minutes), and >100 J/cm2 (60 minutes); and with 10 mg/kg, 11.7 J/cm2 (30 minutes) and 54.1 J/cm2 (60 minutes). Histology of the angiographically hypofluorescent lesions revealed vessel thrombosis in all groups 1 hour after PDT up to 7 days after treatment. Sparing of photoreceptors indicated selectivity of T-PDT; however, slight damage was partly observable. After 7 days, localized proliferation of the RPE cells was noted and was enhanced 14 days after treatment. CONCLUSIONS: T-PDT has the potential to achieve selective choroidal vessel occlusion with proper parameter selection, such as (1) 2.5 mg/kg, 5 minutes, 100 J/cm2; (2) 5 mg/kg, 5 minutes, 25 J/cm2; or (3) 5 mg/kg, 15 minutes, 50 J/cm2; however, slight damage to the photoreceptors cannot be ruled out. RPE proliferation indicates primary RPE damage due to PDT, also described with the use of all other photosensitizers.},
       keywords = {Animals
    Bacteriochlorophylls/*administration & dosage
    Choroid/*blood supply/drug effects/pathology
    Choroidal Neovascularization/diagnosis/*drug therapy
    Drug Evaluation, Preclinical
    Fluorescein Angiography
    *Photochemotherapy
    Photosensitizing Agents/*administration & dosage
    Rabbits},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17122134},
       year = {2006},
       type = {Journal Article}
    }
    
  • Framme, C. and Flucke, B. and Birngruber, R.: Comparison of reduced and standard light application in photodynamic therapy of the eye in two rabbit models. Graefes Arch Clin Exp Ophthalmol, no. 244, pp. 773-81, 2006
    BibTeX Link
    @article{Famme2006,
       author = {Framme, C. and Flucke, B. and Birngruber, R.},
       title = {Comparison of reduced and standard light application in photodynamic therapy of the eye in two rabbit models},
       journal = {Graefes Arch Clin Exp Ophthalmol},
       volume = {244},
       number = {7},
       pages = {773-81},
       note = {0721-832X (Print)
    Comparative Study
    Journal Article},
       abstract = {BACKGROUND: Current PDT treatment for age-related macular degeneration uses a standard radiant exposure of 50 J/cm(2) at an irradiance of 600 mW/cm(2). However; there is a general problem with the unusually high irradiance; in fact, the rate of photochemical production of singlet oxygen may be limited by insufficiently oxygenized neovascular tissue. It was the aim of this study to evaluate the efficacy of verteporfin (Visudyne) photoactivation to induce thrombosis of choriocapillaries and in experimentally induced corneal neovascularizations in rabbits by varying irradiance and retinal radiant exposure. MATERIALS AND METHODS: The light-dose threshold to induce micro-thrombosis in the choriocapillaries (seven eyes) and in corneal neovascularizations (eight eyes) of Chinchilla-Bastard rabbits using different retinal irradiances (100 and 600 mW/cm(2)) at different radiant exposures (20, 10, 5, 2.5, 1.25, 0.62, and 0.3 J/cm(2)) was evaluated. Induction of neovascularizations was performed 7 days prior to PDT treatment using intracorneal silk sutures. A dose of 2 mg/kg verteporfin was intravenously infused 10 min before standard PDT. The criterion for vascular thrombosis was vessel closure as determined by fluorescein angiography 1 h and 1 day post exposure. RESULTS: Experiments on the choroid revealed vessel closure 1 h after irradiation at ED(50) = 10.8 J/cm(2) (both 600 and 100 mW/cm(2)) and after 24 h at ED(50) = 2.4 J/cm(2) (600 mW/cm(2)) versus 1.8 J/cm(2) (100 mW/cm(2)). Vessel closure was enhanced at irradiation with 100 mW/cm(2). Regarding corneal neovascularizations, vessel thrombosis was observable by dark appearance of irradiated clotted neovascular tissue and angiographically by a lack of leakage at ED(50) thresholds of 0.62 J/cm(2) (1 h) and 0.41 J/cm(2) (1 day) for 100 mW/cm(2) and of 0.99 J/cm(2) (1 h), and 0.67 J/cm(2) (1 day) for 600 mW/cm(2). Thus in both experiments thresholds for vessel closure were reduced by a factor of 1.5 for the lower intensity. Histology revealed more selective vessel occlusion without RPE and photoreceptor damage for 100 mW/cm(2) rather than 600 mW/cm(2) intensity at threshold irradiation. CONCLUSION: Low-intensity PDT with verteporfin for neovascular tissue seems to be more effective than regular high-intensity PDT. Future preclinical trials should address the issue of proper dosimetry for effective PDT in age-related macular degeneration.},
       keywords = {Animals
    Choroidal Neovascularization/*drug therapy
    Corneal Neovascularization/*drug therapy
    *Disease Models, Animal
    Fluorescein Angiography
    Photochemotherapy/*methods
    Photosensitizing Agents/*therapeutic use
    Porphyrins/*therapeutic use
    Rabbits
    Radiation Dosage},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16440207},
       year = {2006},
       type = {Journal Article}
    }
    
  • Neumann, J. and Brinkmann, R: Cell disintegration by laser-induced transient microbubbles and its simultaneous monitoring by interferometry. Journal of Biomedical Optics, no. 11, pp. 041112-1 - 041112-11, 2006
    BibTeX
    @article{Neumann,
       author = {Neumann, J. and Brinkmann, R},
       title = {Cell disintegration by laser-induced transient microbubbles and its simultaneous monitoring by interferometry},
       journal = {Journal of Biomedical Optics},
       volume = {11},
       number = {4},
       pages = {041112-1 - 041112-11},
       year = {2006}
    }
  • Huber, Robert and Adler, Desmond C and Fujimoto, James G: Buffered Fourier domain mode locking: unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s. Optics Letters, no. 31, pp. 2975 - 2977, oct,, 2006
    BibTeX Link
    @Article{HU_2006_Huber_b,
      Title                    = {{Buffered Fourier domain mode locking: unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s}},
      Author                   = {Huber, Robert and Adler, Desmond C and Fujimoto, James G},
      Journal                  = {Optics Letters},
      Year                     = {2006},
    
      Month                    = oct,
      Number                   = {20},
      Pages                    = {2975 -- 2977 },
      Volume                   = {31},
    
      Doi                      = {10.1364/OL.31.002975},
      ISSN                     = {0146-9592},
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?URI=ol-31-20-2975}
    }
  • Narumi, T and Hayashi, Y and Ataka, S and Tanaka, R and Murasawa, M and Kohno, T and Shiraki, K: Blunt ocular trauma in a patient with hemophilia-A. Japanese Journal of Clinical Ophthalmology, no. 60, pp. 1653-1656, 2006
    BibTeX
    @article{Hayashi,
       author = {Narumi, T and Hayashi, Y and Ataka, S and Tanaka, R and Murasawa, M and Kohno, T and Shiraki, K},
       title = {Blunt ocular trauma in a patient with hemophilia-A},
       journal = {Japanese Journal of Clinical Ophthalmology},
       volume = {60},
       number = {9},
       pages = {1653-1656},
       abstract = {Purpose?To report a patient with hemophilia-A who was treated by recombinant factor VIII concentrate for trauma-induced hyphema. Case and Findings?A 18-year-old male was hit by a flying softball on his left eye. He noted pain and blurring of left vision. When seen the next day,his visual acuity was hand motion left with intraocular pressure?IOP?of 37mmHg. The left cornea was edematous. The anterior chamber was filled with blood. He was diagnosed with hemophilia A with factor VIII level of 3?. His bleeding time was within normal limit. Irrigation of anterior was performed without incident after intravenous injection of recombinant factor VIII concentrate. Vitreous hemorrhage started to be absorbed 3 weeks after the trauma. Visual acuity improved to 0.02 5 weeks and to 1.5 9 weeks after trauma. Conclusion?Systemic recombinant factor VIII concentrate seemed to facilitate irrigation of anterior chamber and spontaneous absorption of vitreous hemorrhage in a patient with hemophilia-A.},
       year = {2006}
    }
    
  • Daniltchenko, D.: Anwendung der optischen Kohärenztomographie (OCT) bei der Darstellung von Urothelerkrankungen der Harnblase. Der Radiologe, no. 46, pp. 584, 2006
    BibTeX
    @article{Daniltchenko,
       author = {Daniltchenko, D.},
       title = {Anwendung der optischen Kohärenztomographie (OCT) bei der Darstellung von Urothelerkrankungen der Harnblase},
       journal = {Der Radiologe},
       volume = {46},
       number = {7},
       pages = {584},
       year = {2006}
    }
  • Hishida, E and Hayashi, Y. and Narumi, T and Shiraki, K.: A case of Tolosa-Hunt syndrome with optic neuritis and impaired visual acuity. Japanese Journal of Clinical Ophthalmology, no. 60, pp. 943-946, 2006
    BibTeX
    @article{Hayashi2006,
       author = {Hishida, E and Hayashi, Y. and Narumi, T and Shiraki, K.},
       title = {A case of Tolosa-Hunt syndrome with optic neuritis and impaired visual acuity},
       journal = {Japanese Journal of Clinical Ophthalmology},
       volume = {60},
       number = {6},
       pages = {943-946},
       abstract = {Purpose?To report a case of Tolosa-Hunt syndrome with optic neuritis and impaired visual acuity. Case and Findings?A 31-year-old woman presented with retrobulbar pain in her left eye. Her corrected visual acuity was 1.2 right and 0.8 left. The left eye developed total ophthalmoplegia with visual acuity of 0.08 four days later. She was diagnosed with Tolosa-Hunt syndrome with optic neuritis. Pulsed corticosteroid therapy induced improved ocular motility with reduced pain. Visual acuity improved to 0.7. Discontinuation of corticosteroid was followed by severe recurrence. Left visual acuity was reduced to no light perception. Another course of pulsed corticosteroid therapy with peroral prednisolone induced improvement. There has been no recurrence until 9months later. Conclusion?Pulsed corticosteroid therapy with peroral prednisolone may be useful in preventing recurrence of optic neuritis in Tolosa-Hunt syndrome.},
       year = {2006}
    }
    
  • Ueda, S and Hayashi, Y and Kohno, T and Miki, N and Hishida, E and Shiraki, K: A case of pachymeningitis with impaired ocular motility.. Japanese Journal of Clinical Ophthalmology, no. 60, pp. 553-557, 2006
    BibTeX
    @article{Hayashi,
       author = {Ueda, S and Hayashi, Y and Kohno, T and Miki, N and Hishida, E and Shiraki, K},
       title = {A case of pachymeningitis with impaired ocular motility.},
       journal = {Japanese Journal of Clinical Ophthalmology},
       volume = {60},
       number = {4},
       pages = {553-557},
       year = {2006}
    }
    

2005

  • Ahlers, C. and Michels, S. and Elsner, H. and Birngruber, R. and Pruente, C. and Schmidt-Erfurth, U.: Topographic angiography and optical coherence tomography: A correlation of imaging characteristics. European Journal of Ophthalmology, no. 15, pp. 774-781, 2005
    BibTeX Link
    @article{Ahlers2005,
       author = {Ahlers, C. and Michels, S. and Elsner, H. and Birngruber, R. and Pruente, C. and Schmidt-Erfurth, U.},
       title = {Topographic angiography and optical coherence tomography: A correlation of imaging characteristics},
       journal = {European Journal of Ophthalmology},
       volume = {15},
       number = {6},
       pages = {774-781},
       note = {990KX
    Times Cited:8
    Cited References Count:8},
       abstract = {PURPOSE. Topographic angiography (TAG) using confocal scanning laser angiography and optical coherence tomography (OCT) are new imaging modalities that have been introduced during recent years. OCT and TAG imaging were compared to specify the characteristics of each imaging modality.
    METHODS. TAG using fluorescein angiography (FA) provides a three-dimensional pro file of the vascular structures based on the analysis of a set of 32 confocal images over a depth of 4 mm. OCT provides cross-sectional images of the neurosensory retina and the retinal pigment epithelium-choriocapillary complex (RPE-CC). The authors compared and evaluated both modalities in 10 patients with predominantly classic choroidal neovascularization (CNV), 10 patients with serous pigment epithelial detachment (PED), and 10 patients with geographic RPE atrophy, all secondary to age-related macular degeneration (ARMD).
    RESULTS. In patients with classic CNV, TAG detected neovascular structures and delineated their configuration. In PEDs pooling of extravascular fluid is demonstrated, and in geographic RPE atrophy TAG showed reduced choroidal perfusion. Classic CNV was demonstrated by OCT as a hyperreflective band at the level of the RPE-CC, and PED showed a dome-shaped RPE detachment. In geographic RPE atrophy, OCT imaged loss of the RPE band and had an increased depth resolution.
    CONCLUSIONS. TAG and OCT are useful imaging modalities in the evaluation of ARMD cases. TAG visualizes the vascular configuration and dynamic perfusion and leakage changes. OCT is able to document intra-, subretinal, and sub-RPE fluid accumulation secondary to CNV Both modalities may provide further valuable insight into ARMD pathogenesis, enhance diagnostic quality, and improve the assessment of therapeutic effects.},
       keywords = {age-related macular degeneration
    choroidal neovascularization
    geographic atrophy
    imaging
    optical coherence tomography
    pigment epithelial detachment
    topographic angiography
    macular degeneration
    choroidal neovascularization
    disease},
       ISSN = {1120-6721},
       url = {<Go to ISI>://WOS:000233742900019},
       year = {2005},
       type = {Journal Article}
    }
    
  • Huber, R and Wojtkowski, M and Fujimoto, James G and Jiang, J Y and Cable, A E: Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm. Optics Express, no. 13, pp. 10523 - 10538, 2005
    BibTeX Link
    @Article{HU_2005_Huber_d,
      Title                    = {{Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm}},
      Author                   = {Huber, R and Wojtkowski, M and Fujimoto, James G and Jiang, J Y and Cable, A E},
      Journal                  = {Optics Express},
      Year                     = {2005},
      Number                   = {26},
      Pages                    = {10523 -- 10538 },
      Volume                   = {13},
    
      Doi                      = {10.1364/OPEX.13.010523},
      ISSN                     = {1094-4087},
      Url                      = {http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-26-10523}
    }
  • Sharma, Vikas and Kowalevicz Jr., Andrew M and Huber, Robert and Fujimoto, James G and Minoshima, Kaoru: Three Dimensional Waveguide Splitters Fabricated in Glass Using a Femtosecond Laser Oscillator - Technical Digest (CD). in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies, pp. CThCC4, Optical Society of America, 2005
    BibTeX Link
    @InProceedings{HU_2005_Sharma_a,
      Title                    = {{Three Dimensional Waveguide Splitters Fabricated in Glass Using a Femtosecond Laser Oscillator - Technical Digest (CD)}},
      Author                   = {Sharma, Vikas and {Kowalevicz Jr.}, Andrew M and Huber, Robert and Fujimoto, James G and Minoshima, Kaoru},
      Booktitle                = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies},
      Year                     = {2005},
      Pages                    = {CThCC4},
      Publisher                = {Optical Society of America},
    
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?URI=CLEO-2005-CThCC4}
    }
  • Rahmanzadeh, R. and Muller, K. and Fischer, E. and Bartels, D. and Borsch, T.: The Linderniaceae and Gratiolaceae are further lineages distinct from the Scrophulariaceae (Lamiales). no. 7, pp. 67-78, Jan, 2005
    BibTeX
    @misc{Rahmanzadeh,
       author = {Rahmanzadeh, R. and Muller, K. and Fischer, E. and Bartels, D. and Borsch, T.},
       title = {The Linderniaceae and Gratiolaceae are further lineages distinct from the Scrophulariaceae (Lamiales)},
       volume = {7},
       number = {1},
       pages = {67-78},
       month = {Jan},
       note = {Rahmanzadeh, R
    Muller, K
    Fischer, E
    Bartels, D
    Borsch, T
    Research Support, Non-U.S. Gov't
    Germany
    Plant Biol (Stuttg). 2005 Jan;7(1):67-78.},
       abstract = {The Lamiales are one of the largest orders of angiosperms, with about 22,000 species. The Scrophulariaceae, as one of their most important families, has recently been shown to be polyphyletic. As a consequence, this family was re-classified and several groups of former scrophulariaceous genera now belong to different families, such as the Calceolariaceae, Plantaginaceae, or Phrymaceae. In the present study, relationships of the genera Craterostigma, Lindernia and its allies, hitherto classified within the Scrophulariaceae, were analyzed. Sequences of the chloroplast trnK intron and the matK gene (approximately 2.5 kb) were generated for representatives of all major lineages of the Lamiales and the former Scrophulariaceae. Bayesian and parsimony analyses revealed two isolated lineages, one of which consists of Lindernia and its allies, the other of Gratiola and allies. Gratiola was previously assumed to be related to Lindernia and was therefore included here. It is proposed to treat the two clades as separate families, Linderniaceae and Gratiolaceae. For the Linderniaceae, several morphological synapomorphies exist in addition to molecular data, such as conspicuous club-shaped stamen appendages.},
       keywords = {Bayes Theorem
    Genes, Plant
    Introns
    Phenotype
    Phylogeny
    Scrophulariaceae/anatomy & histology/ classification/genetics
    Species Specificity},
       ISBN = {1435-8603 (Print)
    1435-8603 (Linking)},
       year = {2005}
    }
  • Framme, C. and Schuele, G. and Roider, J. and Holz, F. G. and Birngruber, R. and Brinkmann, R.: Temperature dependence of A2-E fluorescence in vitro and detection of fundus autofluorescence during selective RPE laser treatment (SRT). Investigative Ophthalmology & Visual Science, no. 46, 2005
    BibTeX Link
    @article{Framme2005,
       author = {Framme, C. and Schuele, G. and Roider, J. and Holz, F. G. and Birngruber, R. and Brinkmann, R.},
       title = {Temperature dependence of A2-E fluorescence in vitro and detection of fundus autofluorescence during selective RPE laser treatment (SRT)},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {46},
       note = {Suppl. S
    911CZ
    266
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000227980400260},
       year = {2005},
       type = {Journal Article}
    }
    
  • Elsner, H. and Liew, S. H. M. and Klatt, C. and Hamilton, P. and Marshall, J. and Porksen, E. and Laqua, H. and Brinkmann, R. and Birngruber, R. and Roider, J.: Selective-retina-therapy (SRT) multicenter clinical trial: 6 month results in patients with diabetic maculopathy. Investigative Ophthalmology & Visual Science, no. 46, 2005
    BibTeX Link
    @article{Elsner2005,
       author = {Elsner, H. and Liew, S. H. M. and Klatt, C. and Hamilton, P. and Marshall, J. and Porksen, E. and Laqua, H. and Brinkmann, R. and Birngruber, R. and Roider, J.},
       title = {Selective-retina-therapy (SRT) multicenter clinical trial: 6 month results in patients with diabetic maculopathy},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {46},
       note = {Suppl. S
    911CZ
    1463
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000227980401487},
       year = {2005},
       type = {Journal Article}
    }
    
  • Alt, C. and Framme, C. and Schnell, S. and Lee, H. and Brinkmann, R. and Lin, C. P.: Selective targeting of the retinal pigment epithelium using an acousto-optic laser scanner. J Biomed Opt, no. 10, pp. 64014, 2005
    BibTeX
    @article{Alt,
       author = {Alt, C. and Framme, C. and Schnell, S. and Lee, H. and Brinkmann, R. and Lin, C. P.},
       title = {Selective targeting of the retinal pigment epithelium using an acousto-optic laser scanner},
       journal = {J Biomed Opt},
       volume = {10},
       number = {6},
       pages = {64014},
       note = {1083-3668 (Print)
    Journal Article},
       abstract = {Selective targeting of the retinal pigment epithelium (RPE) is a new strategy for treating certain retinal disorders while preserving adjacent photoreceptors. The treatment currently relies on a complex laser system to produce the required microsecond pulse structure. In our new approach, we scan the focus of a continuous-wave (cw) laser beam with acousto-optic deflectors to produce microsecond-long exposures at each RPE cell. Experiments were performed in vitro with a bench-top scanner on samples of young bovine RPE and in vivo on Dutch belted rabbits with a slit-lamp adapted scanner. Effective dose 50% (ED(50)) for RPE damage was determined in vitro by fluorescence cell viability assay and in vivo by fluorescein angiography. Damage to individual RPE cells was achieved with laser power on the order of 100 mW. Using separated scan lines, we demonstrate selectivity in the form of alternating lines of dead and surviving cells that resemble the scan pattern. Selectivity is also shown by the absence of retinal thermal coagulation in vivo. Selective RPE damage is feasible by rapidly scanning a cw laser beam. The scanning device is an attractive alternative to conventional laser coagulation and pulsed laser targeting of the RPE.},
       year = {2005}
    }
  • Poerksen, E. and Elsner, H. and Theisen-Kunde, D. and Schuele, G. and Hamilton, P. and Laqua, H. and Birngruber, R. and Brinkmann, R. and Roider, J.: Selective retina treatment (SRT): Clinical investigation of an optoacoustic on-line dosimetry control. Investigative Ophthalmology & Visual Science, no. 46, 2005
    BibTeX Link
    @article{Poerksen2005,
       author = {Poerksen, E. and Elsner, H. and Theisen-Kunde, D. and Schuele, G. and Hamilton, P. and Laqua, H. and Birngruber, R. and Brinkmann, R. and Roider, J.},
       title = {Selective retina treatment (SRT): Clinical investigation of an optoacoustic on-line dosimetry control},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {46},
       note = {Suppl. S
    911CZ
    294
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000227980400286},
       year = {2005},
       type = {Journal Article}
    }
    
  • Schüle, G and Rumohr, M and Hüttmann, G and Brinkmann, R: RPE damage thresholds and mechanisms for laser exposure in the µs to ms time regimen. Inv Ophthalmol & Vis Sci, no. 46, pp. 714-719, 2005
    BibTeX
    @article{Schüle,
       author = {Schüle, G and Rumohr, M and Hüttmann, G and Brinkmann, R},
       title = {RPE damage thresholds and mechanisms for laser exposure in the µs to ms time regimen},
       journal = {Inv Ophthalmol & Vis Sci},
       volume = {46},
       number = {2},
       pages = {714-719},
       year = {2005}
    }
  • Nakakura, S. and Shiraki, K. and Yasunari, T. and Hayashi, Y. and Ataka, S. and Kohno, T.: Quantification and anatomic distribution of choroidal abnormalities in patients with type I neurofibromatosis. Graefes Arch Clin Exp Ophthalmol, no. 243, pp. 980-4, 2005
    BibTeX
    @article{Hayashi,
       author = {Nakakura, S. and Shiraki, K. and Yasunari, T. and Hayashi, Y. and Ataka, S. and Kohno, T.},
       title = {Quantification and anatomic distribution of choroidal abnormalities in patients with type I neurofibromatosis},
       journal = {Graefes Arch Clin Exp Ophthalmol},
       volume = {243},
       number = {10},
       pages = {980-4},
       note = {Nakakura, Shunsuke
    Shiraki, Kunihiko
    Yasunari, Takaharu
    Hayashi, Yoko
    Ataka, Shinsuke
    Kohno, Takeya
    eng
    Comparative Study
    Germany
    2005/05/14 09:00
    Graefes Arch Clin Exp Ophthalmol. 2005 Oct;243(10):980-4. Epub 2005 Oct 20.},
       abstract = {BACKGROUND: Choroidal abnormality manifesting as a bright patchy lesion under infrared monochromatic light has previously been described in neurofibromatosis type I patients in whom the choroid appears normal under conventional ophthalmoscopic examination or on the fluorescein angiogram. We investigated the correlation between patient age and the number of choroidal abnormalities, as well as the anatomic distribution of choroidal abnormalities in the fundus. METHODS: We examined the fundus of 28 eyes in 14 patients with neurofibromatosis type I. Patients ranged in age from 2 to 38 years and were examined between April 2001 and April 2002 by confocal scanning laser ophthalmoscopy with infrared monochromatic light (780 nm wavelength). We divided the fundus into five regions (one within the retinal vascular arcade and those supero-temporal, infero-temporal, supero-nasal, and infero-nasal to it), and lesions on the border between regions were assigned to the region containing the greater part of the lesion. We studied the total number of choroidal abnormalities and the correlation between the total number and age. RESULTS: A positive correlation was found between the total number of choroidal abnormalities and age (Spearman rank correlation coefficient, r=0.6209, P=0.0178). There was a significantly greater number of choroidal abnormalities in the arcade region than in the other four regions (ANOVA, P<0.001). CONCLUSIONS: Choroidal abnormalities tend to increase with age and are most often observed within the vascular arcade.},
       keywords = {Adolescent
    Adult
    Child
    Child, Preschool
    Choroid/*abnormalities
    Choroid Diseases/complications/epidemiology/*pathology
    Female
    Fundus Oculi
    Humans
    Lasers/diagnostic use
    Male
    Neurofibromatosis 1/*complications/pathology
    Ophthalmoscopy/methods
    Prevalence
    Retrospective Studies},
       year = {2005}
    }
    
  • Kasahara, F and Yokoyama, T and Hayashi, Y and Kato, Y and Yamaguchi, M and Shiraki, K: Postoperative results of distance stereoacuity in intermittent exotropia. Japanese Review of Clinical Ophthalmology, no. 99, pp. 246-249, 2005
    BibTeX
    @article{Hayashi,
       author = {Kasahara, F and Yokoyama, T and Hayashi, Y and Kato, Y and Yamaguchi, M and Shiraki, K},
       title = {Postoperative results of distance stereoacuity in intermittent exotropia},
       journal = {Japanese Review of Clinical Ophthalmology},
       volume = {99},
       number = {3},
       pages = {246-249},
       year = {2005}
    }
    
  • Herrmann, K and Birngruber, R. and Pauleikhoff, D.: Photodynamische Therapie in der Praxis immer breiter eingesetzt.. Beilage für Der Ophthalmologe, no. 102, 2005
    BibTeX
    @article{Herrmann2005,
       author = {Herrmann, K and Birngruber, R. and Pauleikhoff, D.},
       title = {Photodynamische Therapie in der Praxis immer breiter eingesetzt.},
       journal = {Beilage für "Der Ophthalmologe"},
       volume = {102},
       number = {6},
       year = {2005},
       type = {Journal Article}
    }
    
  • Huber, Robert and Köhler, Thomas and Lenz, Martin O and Bamberg, Ernst and Kalmbach, Rolf and Engelhard, Martin and Wachtveitl, Josef: pH-dependent photoisomerization of retinal in proteorhodopsin.. Biochemistry, no. 44, pp. 1800-6, feb,, 2005
    BibTeX Link
    @Article{HU_2005_Huber_e,
      Title                    = {{pH-dependent photoisomerization of retinal in proteorhodopsin.}},
      Author                   = {Huber, Robert and K\"{o}hler, Thomas and Lenz, Martin O and Bamberg, Ernst and Kalmbach, Rolf and Engelhard, Martin and Wachtveitl, Josef},
      Journal                  = {Biochemistry},
      Year                     = {2005},
    
      Month                    = feb,
      Number                   = {6},
      Pages                    = {1800--6},
      Volume                   = {44},
    
      Doi                      = {10.1021/bi048318h},
      ISSN                     = {0006-2960},
      Url                      = {http://pubs.acs.org/doi/abs/10.1021/bi048318h}
    }
    
  • Schuele, G. and Elsner, H. and Framme, C. and Roider, J. and Birngruber, R. and Brinkmann, R.: Optoacoustic real-time dosimetry for selective retina treatment. Journal of Biomedical Optics, no. 10, 2005
    BibTeX Link Link
    @article{Schuele2005,
       author = {Schuele, G. and Elsner, H. and Framme, C. and Roider, J. and Birngruber, R. and Brinkmann, R.},
       title = {Optoacoustic real-time dosimetry for selective retina treatment},
       journal = {Journal of Biomedical Optics},
       volume = {10},
       number = {6},
       note = {005XJ
    Times Cited:17
    Cited References Count:37},
       abstract = {The selective retina treatment ( SRT ) targets retinal diseases associated with disorders in the retinal pigment epithelium ( RPE ). Due to the ophthalmoscopic invisibility of the laser- induced RPE effects, we investigate a noninvasive optoacoustic real- time dosimetry system. In vitro porcine RPE is irradiated with a Nd: YLF laser ( 527 nm, 1.7- mu s pulse duration, 5 to 40 mu J, 30 pulses, 100- Hz repetition rate). Generated acoustic transients are measured with a piezoelectric transducer. During 27 patient treatments, the acoustic transients are measured with a transducer embedded in an ophthalmic contact lens. After treatment, RPE damage is visualized by fluorescein angiographic leakage. Below the RPE damage threshold, the optoacoustic transients show no pulse- to- pulse fluctuations within a laser pulse train. Above threshold, fluctuations of the individual transients among each other are observed. If optoacoustic pulse- to- pulse fluctuations are present, RPE leakage is observed in fluorescein angiography. In 96% of the irradiated areas, RPE leakage correlated with the optoacoustic defined threshold value. A noninvasive optoacoustic real- time dosimetry for SRT is developed and proved in vitro and during patient treatment. It detects the ophthalmoscopically invisible laser- induced damage of RPE cells and overcomes practical limitations of SRT for use in private practice. (C) 2005 Society of Photo- Optical Instrumentation Engineers.},
       keywords = {selective retina treatment
    optoacoustic dosimetry
    real-time dosimetry
    laser
    retina
    randomized clinical-trial
    macular degeneration
    diabetic-retinopathy
    photocoagulation
    nanosecond
    eye
    temperature
    generation
    liquids
    regimen},
       ISSN = {1083-3668},
       DOI = {Artn 064022
    Doi 10.1117/1.2136327},
       url = {<Go to ISI>://WOS:000234859400024},
       year = {2005},
    
  • Schuele, G. and Elsner, H. and Framme, C. and Roider, J. and Birngruber, R. and Brinkmann, R.: Optoacoustic real-time dosimetry for selective retina treatment. J Biomed Opt, no. 10, pp. 064022, 2005
    BibTeX
    @article{Schuele,
       author = {Schuele, G. and Elsner, H. and Framme, C. and Roider, J. and Birngruber, R. and Brinkmann, R.},
       title = {Optoacoustic real-time dosimetry for selective retina treatment},
       journal = {J Biomed Opt},
       volume = {10},
       number = {6},
       pages = {064022},
       note = {1083-3668 (Print)
    Journal Article},
       abstract = {The selective retina treatment (SRT) targets retinal diseases associated with disorders in the retinal pigment epithelium (RPE). Due to the ophthalmoscopic invisibility of the laser-induced RPE effects, we investigate a noninvasive optoacoustic real-time dosimetry system. In vitro porcine RPE is irradiated with a Nd:YLF laser (527 nm, 1.7-micros pulse duration, 5 to 40 microJ, 30 pulses, 100-Hz repetition rate). Generated acoustic transients are measured with a piezoelectric transducer. During 27 patient treatments, the acoustic transients are measured with a transducer embedded in an ophthalmic contact lens. After treatment, RPE damage is visualized by fluorescein angiographic leakage. Below the RPE damage threshold, the optoacoustic transients show no pulse-to-pulse fluctuations within a laser pulse train. Above threshold, fluctuations of the individual transients among each other are observed. If optoacoustic pulse-to-pulse fluctuations are present, RPE leakage is observed in fluorescein angiography. In 96% of the irradiated areas, RPE leakage correlated with the optoacoustic defined threshold value. A noninvasive optoacoustic real-time dosimetry for SRT is developed and proved in vitro and during patient treatment. It detects the ophthalmoscopically invisible laser-induced damage of RPE cells and overcomes practical limitations of SRT for use in private practice.},
       keywords = {Acoustics/*instrumentation
    Animals
    Computer Systems
    Dose-Response Relationship, Radiation
    Equipment Design
    Equipment Failure Analysis
    Humans
    Laser Coagulation/*methods
    Lasers/*therapeutic use
    Optics/*instrumentation
    Radiation Dosage
    Radiometry/*instrumentation/methods
    Reproducibility of Results
    Retina/pathology/*radiation effects/*surgery
    Sensitivity and Specificity
    Swine},
       year = {2005}
    }
  • Framme, C and Roider, J and Sachs, H G and Brinkmann, R and Gabel, V-P: Noninvasive Imaging and Monitoring of Retinal Pigment Epithelium Patterns Using Fundus Autofluorescence - Review. Curr Med Imag Rev, no. 1, pp. 89-103, 2005
    BibTeX
    @article{Framme,
       author = {Framme, C and Roider, J and Sachs, H G and Brinkmann, R and Gabel, V-P},
       title = {Noninvasive Imaging and Monitoring of Retinal Pigment Epithelium Patterns Using Fundus Autofluorescence - Review},
       journal = {Curr Med Imag Rev},
       volume = {1},
       pages = {89-103},
       year = {2005}
    }
  • Brinkmann, R. and Kandulla, J. and Elsner, H. and Hilmes, M. and Hartert, C. and Birngruber, R.: Non-invasive real-time retinal temperature determination during TTT. Investigative Ophthalmology & Visual Science, no. 46, 2005
    BibTeX Link
    @article{Brinkmann2005,
       author = {Brinkmann, R. and Kandulla, J. and Elsner, H. and Hilmes, M. and Hartert, C. and Birngruber, R.},
       title = {Non-invasive real-time retinal temperature determination during TTT},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {46},
       note = {Suppl. S
    911CZ
    1406
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000227980401431},
       year = {2005},
       type = {Journal Article}
    }
    
  • Hüttmann, Gereon and Yao, Cuiping and Endl, Elmar: New concepts in laser medicine: Towards a laser surgery with cellular precision. Medical laser application, no. 20, pp. 135-139, 2005
    BibTeX
    @article{Hüttmann2005,
       author = {Hüttmann, Gereon and Yao, Cuiping and Endl, Elmar},
       title = {New concepts in laser medicine: Towards a laser surgery with cellular precision},
       journal = {Medical laser application},
       volume = {20},
       number = {2},
       pages = {135-139},
       abstract = {New concepts and instrumentation in laser medicine are driven by the progress in optical technology as well as by advances in the understanding of the interaction of optical irradiation with tissue, especially at a macromolecular scale, and by the changing needs in health care. Complexity and costs of laser sources will decrease due to the use of semiconductor and fiber lasers, and complex or non-linear mechanisms by which the radiation effects tissues are better understood, especially when ultra-short laser pulses are used. Especially femtosecond lasers and nanotechnology have the potential to treat diseases at a cellular level. Focused femtosecond irradiation was successfully used to manipulate tissues with subcellular precision. Laser-irradiated nanoparticles can selectively destroy individual cells.},
       keywords = {Mikro- und Nanowirkungen
    Selective Foto thermolyse
    Faserlaser
    Femtosekundenlaser
    Nanopartikel
    Micro- and nanoeffects
    Selective photothermolysis
    Fiber laser
    Femtosecond laser
    Nanoparticles},
       year = {2005}
    }
  • Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.: Mechanisms of femtosecond laser nanosurgery of biological cells and tissues. Appl. Phys B, no. 81, pp. 1015-1047, 2005
    BibTeX
    @article{Vogel2005,
       author = {Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.},
       title = {Mechanisms of femtosecond laser nanosurgery of biological cells and tissues},
       journal = {Appl. Phys B},
       volume = {81},
       pages = {1015-1047},
       year = {2005}
    }
  • Schmidt-Erfurth, U. and Michels, S. and Indorf, L. and Eggers, R. and Birngruber, R.: Mechanism of photodynamic occlusion using liposomal Zn(II)-phtalocyanine. Current Eye Research, no. 30, pp. 601-612, 2005
    BibTeX Link
    @article{Schmidt-Erfurth2005,
       author = {Schmidt-Erfurth, U. and Michels, S. and Indorf, L. and Eggers, R. and Birngruber, R.},
       title = {Mechanism of photodynamic occlusion using liposomal Zn(II)-phtalocyanine},
       journal = {Current Eye Research},
       volume = {30},
       number = {7},
       pages = {601-612},
       note = {953LO
    Times Cited:2
    Cited References Count:30},
       abstract = {Purpose: To evaluate the potential of liposomal Zinc(II)phthalocyanine (ZnPc) to selectively target subretinal vasculature. Methods: Photodynamic therapy (PDT) with liposomal Zinc(II)-phtalocyanine was used to induce choroidal occlusion in eyes of pigmented rabbits. Drug doses of 0.16, 0.24, 0.32, and 0.4 mg/kg body weight were administered. Photosensitization was performed at a wavelength of 671 nm and an irradiance of 100 mW/cm(2) applying fluences of 5, 10, 20, and 50 J/cm(2). Results: Using liposomal ZnPc, occlusion of choroidal vessels was achieved without damage to the overlying neurosensory retina. A tight dose correlation was found with a drug dose of 0.32 mg/kg and a light dose of 10 J/cm(2) inducing a selective thrombosis of the subretinal capillary layer. Histology revealed a selective intravascular alteration of the endothelial cells. Conclusions: PDT using liposomal ZnPc allows occlusion of subretinal vasculature with maintenance of neuroretina and RPE. The destructive effect on choroidal vascular endothelium is intensive.},
       keywords = {choroidal vasculature
    liposomes
    photodynamic therapy
    zinc(ii)-phtalocyanine
    low-density-lipoprotein
    receptor-mediated uptake
    choroidal neovascularization
    macular degeneration
    endothelial-cells
    therapy
    verteporfin
    angiography
    model},
       ISSN = {0271-3683},
       DOI = {Doi 10.1080/02713680590968286},
       url = {<Go to ISI>://WOS:000231078000012},
       year = {2005},
       type = {Journal Article}
    }
    
  • Apitz, I. and Vogel, A.: Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin. Applied Physics A: Materials Science & Processing, no. 81, pp. 329-338, 2005
    BibTeX
    @article{Apitz,
       author = {Apitz, I. and Vogel, A.},
       title = {Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin},
       journal = {Applied Physics A: Materials Science & Processing},
       volume = {81},
       number = {2},
       pages = {329-338},
       abstract = {We investigated the mechanisms of material ejection in Q-switched Er:YAG laser tissue ablation (70-ns pulse duration) where moderate and large radiant exposures are associated with large volumetric energy densities in the target material. For water, an initial phase of non-equilibrium surface vaporization is followed by an explosive vaporization of the superficial liquid volume from a supercritical state. The ablation of deeper layers with lower peak temperatures proceeds as phase explosion. For mechanically strong tissues, non-equilibrium surface vaporization is followed by a vapour explosion coupled with thermal dissociation of the biomolecules into volatile products. In deeper layers, ablation proceeds as confined boiling with mechanical tearing of the tissue matrix by the vapour pressure. The recoil stress induced at a radiant exposure of 5.4 J/cm 2 is in the order of 500–900 MPa. For water and soft tissues such as liver, the recoil causes a powerful secondary material expulsion. For stronger tissues such as skin, no secondary expulsion was observed even though the recoil stress largely exceeds the static tensile strength of the tissue. Recoil-induced material expulsion results in an increase of both ablation efficiency and mechanical side effects of ablation. Theoretical modelling of the succession of phase transitions in nanosecond-laser tissue ablation and of recoil-induced material expulsion remain a major challenge for future work.},
       keywords = {Physik und Astronomie},
       year = {2005}
    }
  • Yamaguchi, M and Yokoyama, T and Tamaoki, S and Hayashi, Y and Tabuchi, H and Shiraki, K: Lateral rectus posterior-fixation suture for large-angle exotropia. Japanese Review of Clinical Ophthalmology, no. 99, pp. 307-311, 2005
    BibTeX
    @article{Hayashi,
       author = {Yamaguchi, M and Yokoyama, T and Tamaoki, S and Hayashi, Y and Tabuchi, H and Shiraki, K},
       title = {Lateral rectus posterior-fixation suture for large-angle exotropia},
       journal = {Japanese Review of Clinical Ophthalmology},
       volume = {99},
       number = {4},
       pages = {307-311},
       year = {2005}
    }
    
  • Geerling, G. and Muller, M. and Winter, C. and Hoerauf, H. and Oelckers, S. and Laqua, H. and Birngruber, R.: Intraoperative 2-dimensional optical coherence tomography as a new tool for anterior segment surgery. Arch Ophthalmol, no. 123, pp. 253-7, 2005
    BibTeX Link
    @article{Geerling2005,
       author = {Geerling, G. and Muller, M. and Winter, C. and Hoerauf, H. and Oelckers, S. and Laqua, H. and Birngruber, R.},
       title = {Intraoperative 2-dimensional optical coherence tomography as a new tool for anterior segment surgery},
       journal = {Arch Ophthalmol},
       volume = {123},
       number = {2},
       pages = {253-7},
       note = {0003-9950 (Print)
    Journal Article},
       abstract = {We tested a 1310-nm optical coherence tomograph coupled with a beam splitter on the front lens of an operating microscope for intraoperative, noncontact visualization of anterior segment procedures. This new modification of optical coherence tomography technology allows intraoperative, high-resolution, cross-sectional imaging and pachymetry of the cornea and sclera during anterior segment surgery. It is particularly helpful for lamellar dissection techniques such as deep anterior lamellar keratoplasty and trabeculectomy.},
       keywords = {Anterior Eye Segment/*surgery
    Cornea/pathology
    Corneal Transplantation/methods
    Diagnostic Techniques, Ophthalmological/*instrumentation
    Humans
    Monitoring, Intraoperative/*instrumentation
    *Ophthalmologic Surgical Procedures
    Sclera/pathology
    Tomography, Optical Coherence/*instrumentation
    Trabecular Meshwork/pathology
    Trabeculectomy/methods},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15710824},
       year = {2005},
       type = {Journal Article}
    }
    
  • Huber, Robert and Taira, Kenji and Ko, Tony H and Wojtkowski, Maciej and Srinivasan, Vivek and Hsu, Kevin and Fujimoto, James G: High-Speed, Amplified, Frequency Swept Laser at 20 kHz Sweep Rates for OCT Imaging - Technical Digest (CD). in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies, pp. JThE33, Optical Society of America, 2005
    BibTeX
    @InProceedings{HU_2005_Huber_b,
      Title                    = {{High-Speed, Amplified, Frequency Swept Laser at 20 kHz Sweep Rates for OCT Imaging - Technical Digest (CD)}},
      Author                   = {Huber, Robert and Taira, Kenji and Ko, Tony H and Wojtkowski, Maciej and Srinivasan, Vivek and Hsu, Kevin and Fujimoto, James G},
      Booktitle                = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies},
      Year                     = {2005},
      Pages                    = {JThE33},
      Publisher                = {Optical Society of America},
    
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?URI=QELS-2005-JThE33}
    }
  • Huber, Robert and Taira, Kenji and Wojtkowski, Maciej and Ko, Tony H and Fujimoto, James G and Hsu, Kevin: High-speed frequency swept light source for Fourier domain OCT at 20 kHz A-scan rate. in Biomedical Optics 2005, pp. 96-100, International Society for Optics and Photonics, apr,, 2005
    BibTeX Link
    @InProceedings{HU_2005_Huber_f,
      Title                    = {{High-speed frequency swept light source for Fourier domain OCT at 20 kHz A-scan rate}},
      Author                   = {Huber, Robert and Taira, Kenji and Wojtkowski, Maciej and Ko, Tony H and Fujimoto, James G and Hsu, Kevin},
      Booktitle                = {Biomedical Optics 2005},
      Year                     = {2005},
      Editor                   = {Tuchin, Valery V and Izatt, Joseph A and Fujimoto, James G},
      Month                    = apr,
      Pages                    = {96--100},
      Publisher                = {International Society for Optics and Photonics},
    
      Doi                      = {10.1117/12.592552},
      Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1323562}
    }
  • Huber, Robert A and Taira, Kenji and Fujimoto, James G: Fourier Domain Mode Locking: Overcoming limitations of frequency swept light sources and pulsed lasers. in Conference on Lasers and Electro-Optics Europe/ European Quantum Electronics Conference (CLEO/Europe - EQEC 2005), 2005
    BibTeX
    @InProceedings{HU_2005_Huber_a,
      Title                    = {{Fourier Domain Mode Locking: Overcoming limitations of frequency swept light sources and pulsed lasers}},
      Author                   = {Huber, Robert A and Taira, Kenji and Fujimoto, James G},
      Booktitle                = {Conference on Lasers and Electro-Optics Europe/ European Quantum Electronics Conference (CLEO/Europe - EQEC 2005)},
      Year                     = {2005}
    }
  • Huber, R and Taira, K and Wojtkowski, M and Fujimoto, J G: Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates. in European Conference on Biomedical Optics 2005, pp. 58611B-58611B-6, International Society for Optics and Photonics, jun,, 2005
    BibTeX Link
    @InProceedings{HU_2005_Huber_g,
      Title                    = {{Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates}},
      Author                   = {Huber, R and Taira, K and Wojtkowski, M and Fujimoto, J G},
      Booktitle                = {European Conference on Biomedical Optics 2005},
      Year                     = {2005},
      Editor                   = {Drexler, Wolfgang},
      Month                    = jun,
      Pages                    = {58611B--58611B--6},
      Publisher                = {International Society for Optics and Photonics},
    
      Doi                      = {10.1117/12.641732},
      Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=867251}
    }
  • Yao, C. and Rahmanzadeh, R. and Endl, E. and Zhang, Z. and Gerdes, J. and Huttmann, G.: Elevation of plasma membrane permeability by laser irradiation of selectively bound nanoparticles. J Biomed Opt, no. 10, pp. 064012, 2005
    BibTeX
    @article{Yao,
       author = {Yao, C. and Rahmanzadeh, R. and Endl, E. and Zhang, Z. and Gerdes, J. and Huttmann, G.},
       title = {Elevation of plasma membrane permeability by laser irradiation of selectively bound nanoparticles},
       journal = {J Biomed Opt},
       volume = {10},
       number = {6},
       pages = {064012},
       note = {Yao, Cuiping
    Rahmanzadeh, Ramtin
    Endl, Elmar
    Zhang, Zhenxi
    Gerdes, Johannes
    Huttmann, Gereon
    Research Support, Non-U.S. Gov't
    United States
    J Biomed Opt. 2005 Nov-Dec;10(6):064012.},
       abstract = {Irradiation of nanoabsorbers with pico- and nanosecond laser pulses could result in thermal effects with a spatial confinement of less than 50 nm. Therefore absorbing nanoparticles could be used to create controlled cellular effects. We describe a combination of laser irradiation with nanoparticles, which changes the plasma membrane permeability. We demonstrate that the system enables molecules to penetrate impermeable cell membranes. Laser light at 532 nm is used to irradiate conjugates of colloidal gold, which are delivered by antibodies to the plasma membrane of the Hodgkin's disease cell line L428 and/or the human large-cell anaplastic lymphoma cell line Karpas 299. After irradiation, membrane permeability is evaluated by fluorescence microscopy and flow cytometry using propidium iodide (PI) and fluorescein isothiocyanate (FITC) dextran. The fraction of transiently permeabilized and then resealed cells is affected by the laser parameter, the gold concentration, and the membrane protein of the different cell lines to which the nanoparticles are bound. Furthermore, a dependence on particle size is found for these interactions in the different cell lines. The results suggest that after optimization, this method could be used for gene transfection and gene therapy.},
       keywords = {Biopolymers/pharmacokinetics
    Cell Line, Tumor
    Cell Membrane Permeability/ physiology/ radiation effects
    Drug Delivery Systems/ methods
    Fluoresceins/ pharmacokinetics
    Humans
    Lasers
    Lymphoma/ metabolism
    Nanostructures},
       year = {2005}
    }
  • Vogel, A and Lorenz, B. and Sägmüller, B. and Schütze, K.: Catapulting of microdissected histologic specimens with focused and defocused laser pulses. Optical Society of America, 2005
    BibTeX
    @article{Vogel,
       author = {Vogel, A and Lorenz, B. and Sägmüller, B. and Schütze, K.},
       title = {Catapulting of microdissected histologic specimens with focused and defocused laser pulses},
       journal = {Optical Society of America},
       year = {2005}
    }
  • Neumann, J and Brinkmann, R: Boiling nucleation on melanosomes and microbeads transiently heated by nanosecond and microsecond laser pulses.. J Biomed Optics, no. 10, pp. 024001, 2005
    BibTeX
    @article{Neumann,
       author = {Neumann, J and Brinkmann, R},
       title = {Boiling nucleation on melanosomes and microbeads transiently heated by nanosecond and microsecond laser pulses.},
       journal = {J Biomed Optics},
       volume = {10},
       number = {2},
       pages = {024001},
       year = {2005}
    }
  • Huber, R and Wojtkowski, M and Taira, K and Fujimoto, J. G. and Hsu, K: Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles. Optics Express, no. 13, pp. 3513 - 3528, may,, 2005
    BibTeX Link
    @Article{HU_2005_Huber_c,
      Title                    = {{Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles}},
      Author                   = {Huber, R and Wojtkowski, M and Taira, K and Fujimoto, J. G. and Hsu, K},
      Journal                  = {Optics Express},
      Year                     = {2005},
    
      Month                    = may,
      Number                   = {9},
      Pages                    = {3513 -- 3528 },
      Volume                   = {13},
    
      Doi                      = {10.1364/OPEX.13.003513},
      ISSN                     = {1094-4087},
      Url                      = {http://www.opticsexpress.org/abstract.cfm?URI=OPEX-13-9-3513}
    }
  • Hamaguchi, A and Hayashi, Y and Motoyama, T and Imamura, H and Imamoto, K and Kohno, T and Shiraki, K: A case of bilateral endogenous bacterial endophthalmitis. Folia ophthalmologica Japonica, no. 56, pp. 826-830, 2005
    BibTeX
    @article{Hamaguchi,
       author = {Hamaguchi, A and Hayashi, Y and Motoyama, T and Imamura, H and Imamoto, K and Kohno, T and Shiraki, K},
       title = {A case of bilateral endogenous bacterial endophthalmitis},
       journal = {Folia ophthalmologica Japonica},
       volume = {56},
       number = {10},
       pages = {826-830},
       year = {2005}
    }