@inproceedings{Karpf:13,
author = {Sebastian Karpf and Matthias Eibl and Wolfgang Wieser and Thomas Klein and Robert Huber},
booktitle = {CLEO: 2013},
journal = {CLEO: 2013},
keywords = {Lasers, fiber; Scattering, stimulated Raman; Spectroscopy, Raman; Fourier domain mode locking; Lasers; Optical coherence tomography; Raman lasers; Raman spectroscopy; Swept lasers},
pages = {CTu2H.5},
publisher = {Optica Publishing Group},
title = {FDML Raman: High Speed, High Resolution Stimulated Raman Spectroscopy with Rapidly Wavelength Swept Lasers},
year = {2013},
url = {https://opg.optica.org/abstract.cfm?URI=CLEO_SI-2013-CTu2H.5},
doi = {10.1364/CLEO_SI.2013.CTu2H.5},
abstract = {An all fiber based system for high speed, high resolution Raman sensing is presented. The system is based on a wavelength swept Fourier Domain Mode Locked (FDML) laser for the detection of the Raman signal.},
}

@INPROCEEDINGS{6801076,
  author={Eigenwillig, Christoph M. and Todor, Sebastian and Wieser, Wolfgang and Biedermann, Benjamin R. and Klein, Thomas and Jirauschek, Christian and Huber, Robert},
  booktitle={2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC}, 
  title={Picosecond pulses from a Fourier domain mode locked (FDML) laser}, 
  year={2013},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEOE-IQEC.2013.6801076}}

@INPROCEEDINGS{6801995,
  author={Karpf, Sebastian and Eibl, Matthias and Wieser, Wolfgang and Klein, Thomas and Huber, Robert},
  booktitle={2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC}, 
  title={FDML Raman: New high resolution SRS with ultra broadband spectral coverage}, 
  year={2013},
  volume={},
  number={},
  pages={1-1},
  doi={10.1109/CLEOE-IQEC.2013.6801995}}

@inproceedings{10.1117/12.2006979,
author = {Yaokun Zhang and Tom Pfeiffer and Wolfgang Wieser and Marcel Weller and Robert Huber and Thomas Klenzner and J{\"o}rg Raczkowsky and Heinz W{\"o}rn},
title = {{History compounding: a novel speckle reduction technique for OCT guided cochleostomy}},
volume = {8571},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII},
editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {85713H},
abstract = {Optical coherence tomography (OCT) is a promising candidate for monitoring the bottom of the drilled channel during
cochleostomy to prevent injury to the critical structure under the bone tissue. While the thickness of the overlaying bone
tissue is changed during the drilling process, the wave front of the backscattered light is also altered, resulting in
changing speckle patterns of the observed structures in the sequential historical scans. By averaging the different patterns
in these scans, named history compounding, the speckles can be reduced and the detection of critical structure becomes
much easier. Before averaging, the refractive index of bone tissue ???????? has to be compensated so that the speckles of the
same structure in different historical scans can be aligned together. An accurate method for measuring the refractive
index n<sub>b</sub> using OCT is presented. Experiments were conducted to evaluate history compounding and the new technique
is proved to be an effective, flexible and intuitive speckle reduction technique for OCT guided cochleostomy as well as
hard tissue ablation of other kind.},
keywords = {optical coherence tomography, speckle reduction, refractive index, cochleostomy, hard tissue ablation},
year = {2013},
doi = {10.1117/12.2006979},
URL = {https://doi.org/10.1117/12.2006979}
}

@inproceedings{Evers2013,
   author = {Evers, Michael and Welford, David and Manstein, Dieter and Birngruber, Reginald},
   title = {Mid-infrared laser spectroscopy using a tunable gain-switched Cr2+: ZnSe laser},
   booktitle = {Studierendentagung},
   publisher = {Unversität zu Lübeck},
   type = {Conference Proceedings},
URL = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.727.5163&rep=rep1&type=pdf},
year = { 2013}
}

@inproceedings{Baade2013,
   author = {Baade, Alexander and Schlott, Kerstin and Birngruber, Reginald and Brinkmann, Ralf},
   title = {A numerical model for heat and pressure propagation for temperature controlled retinal photocoagulation},
   volume = {8803},
   pages = {88030O-88030O-9},
   note = {10.1117/12.2033590},
   abstract = {Retinal photocoagulation is an established treatment for various retinal diseases. The temperature development during a treatment can be monitored by applying short laser pulses in addition to the treatment laser light. The laser pulses induce thermoelastic pressure waves that can be detected at the cornea. We present a numerical model to examine the temperature development during the treatment as well as the formation and propagation of the ultrasonic waves. Using the model, it is possible to determine the peak temperature during retinal photocoagulation from the measured signal, and investigate the behaviour of the temperature profile and the accuracy of the temperature determination under varying conditions such as inhomogeneous pigmentation or change in irradiation parameters. It was shown that there is an uncertainty of 2.5 -9% in the determination of the peak temperature when the absorption coefficient between the absorbing layers is varied by a factor of 2. Furthermore the model was extended in order to incorporate the photoacoustic pressure generation and wave propagation. It was shown that for an irradiation pulse duration of 75 ns the resulting pressure wave energy is attenuated by 76 % due to frequency dependent attenuation in water.},
   url = {http://dx.doi.org/10.1117/12.2033590},
   type = {Conference Proceedings}, 
year = { 2013}
}

@inproceedings{Rohde2013,
   author = {Rohde, Ingo and Masch, Jennifer- M. and Theisen-Kunde, Dirk and Marczynski-Bühlow, Martin and Lutter, Georg and Brinkmann, Ralf},
   title = {Cardiovascular damage after cw and Q-switched 2μm laser irradiation},
   volume = {8803},
   pages = {88030I-88030I-6},
   note = {10.1117/12.2033550},
   abstract = {Aiming for laser-assisted resection of calcified aortic valve structures for Transcatheter Aortic Valve Implantation (TAVI), a Q-switched Tm:YAG laser emitting at a wavelength of 2.01 μm was used to evaluate the cutting efficiency on highly calcified human aortic leaflets in-vitro. The calcified aortic leaflets were examined regarding ablation rates and debris generation, using a pulse energy of 4.3 mJ, a pulse duration of 0.8-1 μs and a repetition rate of 1 kHz. The radiation was transmitted via a 200 μm core diameter quartz fiber. Resection was performed in a fiber-tissue contact mode on water-covered samples in a dish. The remnant particles were analyzed with respect to quantity and size by light microscopy. Additionally, soft tissue of porcine aortic vessels was examined for histologically detectable thermo-mechanical damage after continuous wave and Q-switched 2μm laser irradiation. An ablation rate of 36.7 ± 25.3 mg/min could be realised on highly calcified aortic leaflets, with 85.4% of the remnant particles being <6 μm in diameter. The maximum damaged area of the soft tissue was < 1 mm for both, cw and pulsed laser irradiation. This limits the expected collateral damage of healthy tissue during the medical procedure. Overall, the Q-switched Tm:YAG laser system showed promising results in cutting calcified aortic valves, transmitting sufficient energy through a small flexible fibre.},
   url = {http://dx.doi.org/10.1117/12.2033550},
   type = {Conference Proceedings},
year = { 2013}
}

@inproceedings{Wurster2013,
   author = {Wurster, Lara M and Warger, W C and Gora, M J and Carruth, R and Tearny, G J and Birngruber, Reginald},
   title = {Design and development of a miniaturized scanning probe},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
URL = {http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.726.9913&rep=rep1&type=pdf},
year = { 2013}
}

@inproceedings{Theisen-Kunde2013,
   author = {Theisen-Kunde, D. and Wolken, H. and Ellebrecht, D. and Danicke, V. and Wurster, L. and Kleemann, M. and Birngruber, R.},
   title = {Investigation of water spray to reduce collateral thermal damage during laser resection of soft tissue},
   volume = {8803},
   pages = {88030F-88030F-4},
   note = {10.1117/12.2032384},
   abstract = {To reduce unwanted collateral thermal damage to surrounding tissue and organs during laparoscopic laser dissection (cw, wavelength: 1.9μm) of porcine liver water spray was used. Size and amount of the produced water droplets of the water spray were photographed by short time imaging and analyzed by imaging software. At in vivo measurements on fresh porcine liver the depth of thermal damage was reduced by 85 % with water spray and the lateral size of thermal damage at the tissue surface could be reduced by 67%. This results show that especially for laparoscopic laser surgery water spray application might be a useful tool to avoid unwanted collateral thermal damage.},
   url = {http://dx.doi.org/10.1117/12.2032384},
   type = {Conference Proceedings}
}

@inproceedings{Fink2013,
   author = {Fink, Peer K and Hillmann, Dierck and Franke, Gesa L and Ramm, Dirk and Koch, P and Hüttmann, Gereon},
   title = {Stray light rejection by structured illumination},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
year = { 2013}
}

@inproceedings{Horstmann2013,
   author = {Horstmann, Jens and Brinkmann, Ralf},
   title = {Non-contact photoacoustic tomography using holographic full field detection},
   publisher = {Proc. SPIE},
   volume = {8800},
   pages = {880007-880007-6},
   note = {10.1117/12.2033599},
   abstract = {An innovative very fast non-contact imaging technique for Photoacoustic Tomography is introduced. It is based on holographic optical speckle detection of a transiently altering surface topography for the reconstruction of absorbing targets. The surface movement is obtained by parallel recording of speckle phase changes known as Electronic Speckle Pattern Interferometry. Due to parallelized 2-D camera detection and repetitive excitation with variable delay with respect to the image acquisition, data recording of whole volumes for Photoacoustic Imaging can be completed in times far below one second. The size of the detected area is scalable by optical magnification. As a proof of concept, an interferometric setup is realized, capable of surface displacement detection with an axial resolution of less than 3 nm. The potential of the proposed method for in vivo Photoacoustic Imaging is discussed.},
   url = {http://dx.doi.org/10.1117/12.2033599},
   type = {Conference Proceedings},
year = { 2013}
}

@inproceedings{Klawitter2013,
   author = {Klawitter, Dominico and Hillmann, Dierck and Pieper, M and Steven, Philipp and Wenzel, J and Hüttmann, Gereon},
   title = {Speckle variance optical coherence tomography for
imaging microcirculation},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
url = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.716.940&rep=rep1&type=pdf},
year = { 2013}
}

@inproceedings{Bliedtner2013,
   author = {Bliedtner, Kathrin and Seifert, Eric and Brinkmann, Ralf},
   title = {Temperature induced tissue deformation monitored
by dynamic speckle interferometry},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
year = { 2013},
url = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.714.8862&rep=rep1&type=pdf}
}

@inproceedings{Fleischhauer2013,
   author = {Fleischhauer, Felix and Schulz-Hildebrandt, Hinnerk and Bonin, Tim and Hüttmann, Gereon},
   title = {Polarization-sensitive optical coherence tomography on different tissues samples for tumor discrimination},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
url = { https://pdfs.semanticscholar.org/a581/a18366acff021e12dcc090b40890ea70dcb8.pdf},
 year = { 2013}
}

@inproceedings{Oepen2013,
   author = {van Oepen, Alexander and Horstmann, Jens and Brinkmann, Ralf},
   title = {Characterization of an Electronic Speckle Pattern Detection System},
   booktitle = {Studierendentagung},
   type = {Conference Proceedings}
}

@inproceedings{Seifert2013,
   author = {Seifert, Eric and Roh, Young-Jung and Fritz, Andreas and Park, Young Gun and Kang, Seungbum and Theisen-Kunde, Dirk and Brinkmann, Ralf},
   title = {Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model},
   volume = {8803},
   pages = {880303-880303-6},
year = {2013},
   note = {10.1117/12.2033560},
   abstract = {Selective Retina Therapy (SRT) targets the Retinal Pigment Epithelium (RPE) without effecting neighboring layers as the photoreceptors or the choroid. SRT related RPE defects are ophthalmoscopically invisible. Owing to this invisibility and the variation of the threshold radiant exposure for RPE damage the treating physician does not know whether the treatment was successful or not. Thus measurement techniques enabling a correct dosing are a demanded element in SRT devices. The acquired signal can be used for monitoring or automatic irradiation control. Existing monitoring techniques are based on the detection of micro-bubbles. These bubbles are the origin of RPE cell damage for pulse durations in the ns and μs time regime 5μs. The detection can be performed by optical or acoustical approaches. Monitoring based on an acoustical approach has already been used to study the beneficial effects of SRT on diabetic macula edema and central serous retinopathy. We have developed a first real time feedback technique able to detect micro-bubble induced characteristics in the backscattered laser light fast enough to cease the laser irradiation within a burst. Therefore the laser energy within a burst of at most 30 pulses is increased linearly with every pulse. The laser irradiation is ceased as soon as micro-bubbles are detected. With this automatic approach it was possible to observe invisible lesions, an intact photoreceptor layer and a reconstruction of the RPE within one week.},
   url = {http://dx.doi.org/10.1117/12.2033560},
   type = {Conference Proceedings}
}

@inproceedings{Sudkamp2013,
   author = {Sudkamp, Helge and Lee, H Y and Hüttmann, Gereon and Kellerbee, A K},
   title = {An approach to increase the speed of Optical Coherence Tomography using a Virtually Imaged Phased Array},
   booktitle = {Studierendentagung},
   publisher = {Universität zu Lübeck},
   type = {Conference Proceedings},
year= { 2013}
}

@inproceedings{10.1117/12.922313,
author = {Sebastian Marschall and Teresa Torzicky and Thomas Klein and Wolfgang Wieser and Michael Pircher and Erich G{\"o}tzinger and Stefan Zotter and Marco Bonesi and Benjamin Biedermann and Christian Pedersen and Robert Huber and Christoph Hitzenberger and Peter Andersen},
title = {{High-speed polarization-sensitive OCT at 1060 nm using a Fourier domain mode-locked swept source}},
volume = {8427},
booktitle = {Biophotonics: Photonic Solutions for Better Health Care III},
editor = {J{\"u}rgen Popp and Wolfgang Drexler and Valery V. Tuchin and Dennis L. Matthews},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {84271D},
abstract = {Optical coherence tomography (OCT) in the 1060nm range is interesting for in vivo imaging of the human
posterior eye segment (retina, choroid, sclera), as it permits a long penetration depth. Complementary to
structural images, polarization-sensitive OCT (PS-OCT) images visualize birefringent, polarization-maintaining
or depolarizing areas within the sample. This information can be used to distinguish retinal layers and structures
with different polarization properties. High imaging speed is crucial for imaging ocular structures in vivo in order
to minimize motion artifacts while acquiring sufficiently large datasets. Here, we demonstrate PS-OCT imaging
at 350 kHz A-scan rate using a two-channel PS-OCT system in conjunction with a Fourier domain mode-locked
laser. The light source spectrum spans up to 100nm around the water absorption minimum at 1060 nm. By
modulating the laser pump current, we can optimize the spectrum and achieve a depth resolution of 9 μm in air
(6.5 μm in tissue). We acquired retinal images in vivo with high resolution and deep penetration into choroid and
sclera, and features like the depolarizing RPE or an increasing phase retardation at the chorio-scleral interface
are clearly visualized.},
keywords = {optical coherence tomography, polarization-sensitive OCT, swept source, Fourier domain mode-locking, 1060 nm},
year = {2012},
doi = {10.1117/12.922313},
URL = {https://doi.org/10.1117/12.922313}
}

@inproceedings{Wieser:12,
author = {Wolfgang Wieser and Thomas Klein and Desmond C. Adler and Francois Tr\'{e}panier and Sebastian Karpf and Christoph M Eigenwillig and Joseph M. Schmitt and Robert Huber},
booktitle = {Conference on Lasers and Electro-Optics 2012},
journal = {Conference on Lasers and Electro-Optics 2012},
keywords = {Optical coherence tomography; Lasers, tunable; Optical coherence tomography; Fiber Bragg gratings; Fourier domain mode locking; Image quality; Laser modes; Mode locking; Optical coherence tomography},
pages = {JTh3J.2},
publisher = {Optica Publishing Group},
title = {Dispersion Compensated Megahertz FDML Laser for Imaging of the Anterior Segment},
year = {2012},
url = {https://opg.optica.org/abstract.cfm?URI=CLEO_AT-2012-JTh3J.2},
doi = {10.1364/CLEO_AT.2012.JTh3J.2},
abstract = {We present a Fourier domain mode locked laser at 1.6 MHz scan rate with greatly improved coherence length by reducing the laser cavity dispersion and the application of this laser in optical coherence tomography.},
}

@inproceedings{10.1117/12.908798,
author = {Thomas Klein and Wolfgang Wieser and Raphael Andr{\'e} and Tom Pfeiffer and Christoph M. Eigenwillig and Robert Huber},
title = {{Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second}},
volume = {8213},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI},
editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {82131E},
abstract = {We demonstrate the acquisition of densely sampled wide-field 3D OCT datasets of the human retina in 0.3s. This
performance is achieved with a multi-MHz Fourier domain mode-locked (FDML) laser source operating at 1050nm. A two-beam
setup doubles the 3.35MHz laser sweep rate to 6.7MHz, which is 16x faster than results achieved with any non-FDML
source used for retinal OCT. We discuss two main benefits of these high line rates: First, large datasets over an ultra-wide
field of view can be acquired with a low probability of distortions. Second, even if eye movements occur, now the scan rate
is high enough to directly correct even the fastest saccades without loss of information.},
keywords = {Optical coherence tomography, OCT, MHz OCT, Fourier-domain mode-locking, FDML, retinal imaging},
year = {2012},
doi = {10.1117/12.908798},
URL = {https://doi.org/10.1117/12.908798}
}

@inproceedings{10.1117/12.906148,
author = {Sebastian Marschall and Thomas Klein and Wolfgang Wieser and Teresa Torzicky and Michael Pircher and Benjamin R. Biedermann and Christian Pedersen and Christoph K. Hitzenberger and Robert Huber and Peter E. Andersen},
title = {{Broadband Fourier domain mode-locked laser for optical coherence tomography at 1060 nm}},
volume = {8213},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI},
editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {82130R},
abstract = {Optical coherence tomography (OCT) in the 1060nm range is interesting for in vivo imaging of the human
posterior eye segment (retina, choroid, sclera) due to low absorption in water and deep penetration into the
tissue. Rapidly tunable light sources, such as Fourier domain mode-locked (FDML) lasers, enable acquisition
of densely sampled three-dimensional datasets covering a wide field of view. However, semiconductor optical
amplifiers (SOAs)-the typical laser gain media for swept sources-for the 1060nm band could until recently
only provide relatively low output power and bandwidth. We have implemented an FDML laser using a new SOA
featuring broad gain bandwidth and high output power. The output spectrum coincides with the wavelength
range of minimal water absorption, making the light source ideal for OCT imaging of the posterior eye segment.
With a moderate SOA current (270 mA) we achieve up to 100nm total sweep range and 12 μm depth resolution
in air. By modulating the current, we can optimize the output spectrum and thereby improve the resolution to
9 μm in air (~6.5 μm in tissue). The average output power is higher than 20mW. Both sweep directions show
similar performance; hence, both can be used for OCT imaging. This enables an A-scan rate of 350 kHz without
buffering the light source output.},
keywords = {optical coherence tomography, tunable laser, swept source, Fourier domain mode-locking, broadband semiconductor optical amplifier},
year = {2012},
doi = {10.1117/12.906148},
URL = {https://doi.org/10.1117/12.906148}
}

@inproceedings{10.1117/12.909830,
author = {Cedric Blatter and Branislav Grajciar and Robert Huber and Rainer A. Leitgeb},
title = {{Deep skin structural and microcirculation imaging with extended-focus OCT}},
volume = {8207},
booktitle = {Photonic Therapeutics and Diagnostics VIII},
editor = {Anita Mahadevan-Jansen and E. Duco Jansen and Andreas Mandelis and Kenton W. Gregory M.D. and Guillermo J. Tearney M.D. and Laura Marcu and Nikiforos Kollias and Bernard Choi and Haishan Zeng and Melissa J. Suter and Stephen Lam and Matthew Brenner and Hyun Wook Kang and Bodo E. Knudsen M.D. and Henry Hirschberg M.D. and Steen Madsen and Brian Jet-Fei Wong M.D. and Justus F. Ilgner M.D. and Krzysztof Izdebski},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {82070B},
abstract = {We present an extended focus OCT system for dermatologic applications that maintains high lateral resolution over a
large depth range by using Bessel beam illumination. More, Bessel beams exhibit a self-reconstruction property that is
particularly useful to avoid shadowing from surface structures such as hairs. High lateral resolution and high-speed
measurement, thanks to a rapidly tuning swept source, allows not only for imaging of small skin structures in depth but
also for comprehensive visualization of the small capillary network within the human skin in-vivo. We use this
information for studying temporal vaso-responses to hypothermia. In contrast to other perfusion imaging methods such
as laser Doppler imaging (LDI), OCT gives specific access to vascular responses in different vascular beds in depth.},
keywords = {Optical Coherence Tomography, FDML Swept Source, Extended focus, Bessel beam, Self-reconstruction property, Microcirculation imaging, Vasomechanics},
year = {2012},
doi = {10.1117/12.909830},
URL = {https://doi.org/10.1117/12.909830}
}

@inproceedings{10.1117/12.908148,
author = {Desmond C. Adler and Wolfgang Wieser and Francois Trepanier and Joseph M. Schmitt and Robert A. Huber},
title = {{Coherence length extension of Fourier domain mode locked lasers}},
volume = {8213},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI},
editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {82130O},
abstract = {Fourier domain mode locked (FDML) lasers provide high sweep rates, broad tuning ranges, and high output powers for
optical coherence tomography (OCT) systems. However, presently-known FDML lasers at 1300 nm have relatively
short coherence lengths, limiting the size of samples that can be imaged. Furthermore, FDML lasers produce only one
useable sweep direction. We report FDML coherence length extension by incorporating advanced dispersion
compensation modules (DCMs). DCMs eliminate group velocity dispersion in the cavity, doubling coherence lengths
and ensuring uniform axial resolution over the imaging range. Additionally, forward and backward sweeps are nearly
identical, removing the need for external buffering stages.},
keywords = {Fourier domain mode locked lasers, FDML, swept source, optical coherence tomography, dispersion compensation},
year = {2012},
doi = {10.1117/12.908148},
URL = {https://doi.org/10.1117/12.908148}
}

@inproceedings{10.1117/12.911443,
author = {Cedric Blatter and Branislav Grajciar and Boris Hermann and Robert Huber and Wolfgang Drexler and Rainer A. Leitgeb},
title = {{Simultaneous dark-bright field swept source OCT for ultrasound detection}},
volume = {8213},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI},
editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {82131M},
abstract = {We introduce a swept source FDOCT imaging system that allows measuring simultaneously the reflected light and
scattered light (bright field) and the scattered light only (dark field) in two different channels through separate Gaussian
and Bessel detection. Specular reflections can then be used to obtain knowledge about the sample time evolution with
high SNR for phase analysis. Based on this configuration, we provide a proof-of principle study for resolving ultrasound
pulse trains with high temporal resolution on surfaces, which potentially provides a novel phase sensitive all optical
detection scheme for the combination of OCT with photoacoustic imaging.},
keywords = {Dark field imaging, Bessel beam, Extended focus, FDML Swept Source, Multichannel detection, Photoacoustic, Ultrasound, Phase sensitive},
year = {2012},
doi = {10.1117/12.911443},
URL = {https://doi.org/10.1117/12.911443}
}

@inproceedings{Hüttmann2012,
   author = {Hüttmann, G. and Orzekowsky-Schröder, R.},
   title = {Imaging of immune cell dynamics in small intestine and the eye  by 2-photon microcopy},
   booktitle = {7th Workshop on Advanced Multiphoton and Fluorescence Lifetime Imaging Techniques (FLIM 2012)},
year = { 2012},
   abstract = {Autofluorescence based 2-photon microscopy was investigated as a
tool for studying the dynamics of immunological processes in vivo. Nearly
all tissue components were simultaneously visible by autofluorescence and a
nearly complete visualization of tissue architecture was possible. Within
the tissue, immune competent cells like lymphocytes, macrophages and
dendritic cells were visualized in their dynamic interaction with other
cells or surrounding tissues.
Immunological processes were studied in the small intestine and at the
surface of the eye. Excitation and emission spectra of the different mucosal
tissue components were quantitatively determined and a compared to the
respective spectra of endogenous chromophores. It was shown, that by using
only two excitation wavelengths within the tuning range of a Ti:Saphire
laser enterocytes, antigen presenting cells and lysosomes of the small
intestine could be discriminated based on the excitation and emission
properties. By additionally using an intravital nuclear stain, motion of
lymphocytes in the lamina propria and the epithelium of small intestine
villi was quantitatively analyzed. 

2-photon microscopy was also a powerful tool for studying the conjunctiva
and cornea of the eye. Lymphocyte dynamics and uptake of microspheres or
fluorescing heat-inactivated E. coli was followed over time in the
conjunctiva-associated lymphoid tissue of mice. In a different mouse model
of suture induced corneal hem- and lymphangiogenesis, immune cell migration
into lymphatic vessels and luminal transport of individual cells was
observed in vivo.

Autofluorescence based 2-photon intravital microscopy is a valuable tool to
study dynamic immunological processes. While tissue autofluorescence gives a
good overview over all relevant structures and allows for discriminating
different cell types by spectral analysis, the additional combination of
specific staining with external dyes or fluorescent proteins is easily
possible and enhances the potential of the technique further. },

}