2013
Tianshi
Wang,
Wolfgang
Wieser,
Geert
Springeling,
Robert
Beurskens,
Charles T.
Lancee,
Tom
Pfeiffer,
Antonius F. W.
van der Steen,
Robert
Huber, and
Gijs
van Soest,
Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second, in Optical Coherence Tomography and Coherence Techniques VI , Brett E. Bouma and Rainer A. Leitgeb, Eds. SPIE, 062013. pp. 88020O.
Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second, in Optical Coherence Tomography and Coherence Techniques VI , Brett E. Bouma and Rainer A. Leitgeb, Eds. SPIE, 062013. pp. 88020O.
DOI: | 10.1117/12.2032723 |
Bibtex: | @inproceedings{10.1117/12.2032723, author = {Tianshi Wang and Wolfgang Wieser and Geert Springeling and Robert Beurskens and Charles T. Lancee and Tom Pfeiffer and Antonius F. W. van der Steen and Robert Huber and Gijs van Soest}, title = {{Ultrahigh-speed intravascular optical coherence tomography imaging at 3200 frames per second}}, volume = {8802}, booktitle = {Optical Coherence Tomography and Coherence Techniques VI}, editor = {Brett E. Bouma and Rainer A. Leitgeb}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {88020O}, abstract = {We demonstrated intravascular OCT imaging with frame rate up to 3.2 kHz (192,000 rpm scanning). This was achieved by using a custom-built catheter in which the circumferential scanning was actuated by a 1.0 mm diameter synchronous motor. The OCT system was based on a Fourier Domain Mode Locked laser operating at an A-line rate of 1.6 MHz. The diameter of the catheter was 1.1 mm at the tip. Ex vivo images of human coronary artery (~78.4 mm length) were acquired at a pullback speed of 100 mm/s. True 3D volumetric imaging of the entire artery, with adequate sampling in all dimensions, was performed in < 1 second acquisition time.}, year = {2013}, doi = {10.1117/12.2032723}, URL = {https://doi.org/10.1117/12.2032723} } |
Sebastian
Karpf,
Matthias
Eibl,
Wolfgang
Wieser,
Thomas
Klein, and
Robert
Huber,
FDML Raman: High Speed, High Resolution Stimulated Raman Spectroscopy with Rapidly Wavelength Swept Lasers, in CLEO: 2013 , Optica Publishing Group, 062013. pp. CTu2H.5.
FDML Raman: High Speed, High Resolution Stimulated Raman Spectroscopy with Rapidly Wavelength Swept Lasers, in CLEO: 2013 , Optica Publishing Group, 062013. pp. CTu2H.5.
DOI: | 10.1364/CLEO_SI.2013.CTu2H.5 |
Bibtex: | @inproceedings{Karpf:13, author = {Sebastian Karpf and Matthias Eibl and Wolfgang Wieser and Thomas Klein and Robert Huber}, booktitle = {CLEO: 2013}, journal = {CLEO: 2013}, keywords = {Lasers, fiber; Scattering, stimulated Raman; Spectroscopy, Raman; Fourier domain mode locking; Lasers; Optical coherence tomography; Raman lasers; Raman spectroscopy; Swept lasers}, pages = {CTu2H.5}, publisher = {Optica Publishing Group}, title = {FDML Raman: High Speed, High Resolution Stimulated Raman Spectroscopy with Rapidly Wavelength Swept Lasers}, year = {2013}, url = {https://opg.optica.org/abstract.cfm?URI=CLEO_SI-2013-CTu2H.5}, doi = {10.1364/CLEO_SI.2013.CTu2H.5}, abstract = {An all fiber based system for high speed, high resolution Raman sensing is presented. The system is based on a wavelength swept Fourier Domain Mode Locked (FDML) laser for the detection of the Raman signal.}, } |
Christoph M.
Eigenwillig,
Sebastian
Todor,
Wolfgang
Wieser,
Benjamin R.
Biedermann,
Thomas
Klein,
Christian
Jirauschek, and
Robert
Huber,
Picosecond pulses from a Fourier domain mode locked (FDML) laser, in 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC , 052013. pp. 1.
Picosecond pulses from a Fourier domain mode locked (FDML) laser, in 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC , 052013. pp. 1.
DOI: | 10.1109/CLEOE-IQEC.2013.6801076 |
Bibtex: | @INPROCEEDINGS{6801076, author={Eigenwillig, Christoph M. and Todor, Sebastian and Wieser, Wolfgang and Biedermann, Benjamin R. and Klein, Thomas and Jirauschek, Christian and Huber, Robert}, booktitle={2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC}, title={Picosecond pulses from a Fourier domain mode locked (FDML) laser}, year={2013}, volume={}, number={}, pages={1-1}, doi={10.1109/CLEOE-IQEC.2013.6801076}} |
Sebastian
Karpf,
Matthias
Eibl,
Wolfgang
Wieser,
Thomas
Klein, and
Robert
Huber,
FDML Raman: New High Resolution SRS with ultra broadband spectral coverage, in 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC , 052013. pp. 1.
FDML Raman: New High Resolution SRS with ultra broadband spectral coverage, in 2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC , 052013. pp. 1.
DOI: | 10.1109/CLEOE-IQEC.2013.6801995 |
Bibtex: | @INPROCEEDINGS{6801995, author={Karpf, Sebastian and Eibl, Matthias and Wieser, Wolfgang and Klein, Thomas and Huber, Robert}, booktitle={2013 Conference on Lasers & Electro-Optics Europe & International Quantum Electronics Conference CLEO EUROPE/IQEC}, title={FDML Raman: New high resolution SRS with ultra broadband spectral coverage}, year={2013}, volume={}, number={}, pages={1-1}, doi={10.1109/CLEOE-IQEC.2013.6801995}} |
Yaokun
Zhang,
Tom
Pfeiffer,
Wolfgang
Wieser,
Marcel
Weller,
Robert
Huber,
Thomas
Klenzner,
Jörg
Raczkowsky, and
Heinz
Wörn,
History compounding: a novel speckle reduction technique for OCT guided cochleostomy, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 032013. pp. 85713H.
History compounding: a novel speckle reduction technique for OCT guided cochleostomy, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 032013. pp. 85713H.
DOI: | 10.1117/12.2006979 |
Bibtex: | @inproceedings{10.1117/12.2006979, author = {Yaokun Zhang and Tom Pfeiffer and Wolfgang Wieser and Marcel Weller and Robert Huber and Thomas Klenzner and J{\"o}rg Raczkowsky and Heinz W{\"o}rn}, title = {{History compounding: a novel speckle reduction technique for OCT guided cochleostomy}}, volume = {8571}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII}, editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {85713H}, abstract = {Optical coherence tomography (OCT) is a promising candidate for monitoring the bottom of the drilled channel during cochleostomy to prevent injury to the critical structure under the bone tissue. While the thickness of the overlaying bone tissue is changed during the drilling process, the wave front of the backscattered light is also altered, resulting in changing speckle patterns of the observed structures in the sequential historical scans. By averaging the different patterns in these scans, named history compounding, the speckles can be reduced and the detection of critical structure becomes much easier. Before averaging, the refractive index of bone tissue ???????? has to be compensated so that the speckles of the same structure in different historical scans can be aligned together. An accurate method for measuring the refractive index n<sub>b</sub> using OCT is presented. Experiments were conducted to evaluate history compounding and the new technique is proved to be an effective, flexible and intuitive speckle reduction technique for OCT guided cochleostomy as well as hard tissue ablation of other kind.}, keywords = {optical coherence tomography, speckle reduction, refractive index, cochleostomy, hard tissue ablation}, year = {2013}, doi = {10.1117/12.2006979}, URL = {https://doi.org/10.1117/12.2006979} } |
H.
Wolken,
D.
Ellebrecht,
L.
Wurster, and
M.
Kleemann,
Investigation of water spray to reduce collateral thermal damage during laser resection of soft tissue, 2013. pp. 88030F-88030F-4.
Investigation of water spray to reduce collateral thermal damage during laser resection of soft tissue, 2013. pp. 88030F-88030F-4.
Datei: | 12.2032384 |
Bibtex: | @inproceedings{Theisen-Kunde2013, author = {Theisen-Kunde, D. and Wolken, H. and Ellebrecht, D. and Danicke, V. and Wurster, L. and Kleemann, M. and Birngruber, R.}, title = {Investigation of water spray to reduce collateral thermal damage during laser resection of soft tissue}, volume = {8803}, pages = {88030F-88030F-4}, note = {10.1117/12.2032384}, abstract = {To reduce unwanted collateral thermal damage to surrounding tissue and organs during laparoscopic laser dissection (cw, wavelength: 1.9μm) of porcine liver water spray was used. Size and amount of the produced water droplets of the water spray were photographed by short time imaging and analyzed by imaging software. At in vivo measurements on fresh porcine liver the depth of thermal damage was reduced by 85 % with water spray and the lateral size of thermal damage at the tissue surface could be reduced by 67%. This results show that especially for laparoscopic laser surgery water spray application might be a useful tool to avoid unwanted collateral thermal damage.}, url = {http://dx.doi.org/10.1117/12.2032384}, type = {Conference Proceedings} } |
Alexander
Baade,
Kerstin
Schlott,
Ralf
Brinkmann, and
Reginald
Birngruber,
A numerical model for heat and pressure propagation for temperature controlled retinal photocoagulation, 2013. pp. 88030O-88030O-9.
A numerical model for heat and pressure propagation for temperature controlled retinal photocoagulation, 2013. pp. 88030O-88030O-9.
Datei: | 12.2033590 |
Bibtex: | @inproceedings{Baade2013, author = {Baade, Alexander and Schlott, Kerstin and Birngruber, Reginald and Brinkmann, Ralf}, title = {A numerical model for heat and pressure propagation for temperature controlled retinal photocoagulation}, volume = {8803}, pages = {88030O-88030O-9}, note = {10.1117/12.2033590}, abstract = {Retinal photocoagulation is an established treatment for various retinal diseases. The temperature development during a treatment can be monitored by applying short laser pulses in addition to the treatment laser light. The laser pulses induce thermoelastic pressure waves that can be detected at the cornea. We present a numerical model to examine the temperature development during the treatment as well as the formation and propagation of the ultrasonic waves. Using the model, it is possible to determine the peak temperature during retinal photocoagulation from the measured signal, and investigate the behaviour of the temperature profile and the accuracy of the temperature determination under varying conditions such as inhomogeneous pigmentation or change in irradiation parameters. It was shown that there is an uncertainty of 2.5 -9% in the determination of the peak temperature when the absorption coefficient between the absorbing layers is varied by a factor of 2. Furthermore the model was extended in order to incorporate the photoacoustic pressure generation and wave propagation. It was shown that for an irradiation pulse duration of 75 ns the resulting pressure wave energy is attenuated by 76 % due to frequency dependent attenuation in water.}, url = {http://dx.doi.org/10.1117/12.2033590}, type = {Conference Proceedings}, year = { 2013} } |
Helge
Sudkamp,
H Y
Lee,
Gereon
Hüttmann, and
A K
Kellerbee,
An approach to increase the speed of Optical Coherence Tomography using a Virtually Imaged Phased Array, in Studierendentagung , Universität zu Lübeck, 2013.
An approach to increase the speed of Optical Coherence Tomography using a Virtually Imaged Phased Array, in Studierendentagung , Universität zu Lübeck, 2013.
Ingo
Rohde,
Jennifer- M.
Masch,
Dirk
Theisen-Kunde,
Martin
Marczynski-Bühlow,
Georg
Lutter, and
Ralf
Brinkmann,
Cardiovascular damage after cw and Q-switched 2μm laser irradiation, 2013. pp. 88030I-88030I-6.
Cardiovascular damage after cw and Q-switched 2μm laser irradiation, 2013. pp. 88030I-88030I-6.
Datei: | 12.2033550 |
Bibtex: | @inproceedings{Rohde2013, author = {Rohde, Ingo and Masch, Jennifer- M. and Theisen-Kunde, Dirk and Marczynski-Bühlow, Martin and Lutter, Georg and Brinkmann, Ralf}, title = {Cardiovascular damage after cw and Q-switched 2μm laser irradiation}, volume = {8803}, pages = {88030I-88030I-6}, note = {10.1117/12.2033550}, abstract = {Aiming for laser-assisted resection of calcified aortic valve structures for Transcatheter Aortic Valve Implantation (TAVI), a Q-switched Tm:YAG laser emitting at a wavelength of 2.01 μm was used to evaluate the cutting efficiency on highly calcified human aortic leaflets in-vitro. The calcified aortic leaflets were examined regarding ablation rates and debris generation, using a pulse energy of 4.3 mJ, a pulse duration of 0.8-1 μs and a repetition rate of 1 kHz. The radiation was transmitted via a 200 μm core diameter quartz fiber. Resection was performed in a fiber-tissue contact mode on water-covered samples in a dish. The remnant particles were analyzed with respect to quantity and size by light microscopy. Additionally, soft tissue of porcine aortic vessels was examined for histologically detectable thermo-mechanical damage after continuous wave and Q-switched 2μm laser irradiation. An ablation rate of 36.7 ± 25.3 mg/min could be realised on highly calcified aortic leaflets, with 85.4% of the remnant particles being <6 μm in diameter. The maximum damaged area of the soft tissue was < 1 mm for both, cw and pulsed laser irradiation. This limits the expected collateral damage of healthy tissue during the medical procedure. Overall, the Q-switched Tm:YAG laser system showed promising results in cutting calcified aortic valves, transmitting sufficient energy through a small flexible fibre.}, url = {http://dx.doi.org/10.1117/12.2033550}, type = {Conference Proceedings}, year = { 2013} } |
Lara M
Wurster,
W C
Warger,
M J
Gora,
R
Carruth, and
G J
Tearny,
Design and development of a miniaturized scanning probe, in Studierendentagung , Universität zu Lübeck, 2013.
Design and development of a miniaturized scanning probe, in Studierendentagung , Universität zu Lübeck, 2013.
Datei: | download |
Bibtex: | @inproceedings{Wurster2013, author = {Wurster, Lara M and Warger, W C and Gora, M J and Carruth, R and Tearny, G J and Birngruber, Reginald}, title = {Design and development of a miniaturized scanning probe}, booktitle = {Studierendentagung}, publisher = {Universität zu Lübeck}, type = {Conference Proceedings}, URL = {http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.726.9913&rep=rep1&type=pdf}, year = { 2013} } |
Kathrin
Bliedtner,
Eric
Seifert, and
Ralf
Brinkmann,
Temperature induced tissue deformation monitored by dynamic speckle interferometry, in Studierendentagung , Universität zu Lübeck, 2013.
Temperature induced tissue deformation monitored by dynamic speckle interferometry, in Studierendentagung , Universität zu Lübeck, 2013.
Datei: | download |
Bibtex: | @inproceedings{Bliedtner2013, author = {Bliedtner, Kathrin and Seifert, Eric and Brinkmann, Ralf}, title = {Temperature induced tissue deformation monitored by dynamic speckle interferometry}, booktitle = {Studierendentagung}, publisher = {Universität zu Lübeck}, type = {Conference Proceedings}, year = { 2013}, url = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.714.8862&rep=rep1&type=pdf} } |
Michael
Evers,
David
Welford, and
Dieter
Manstein,
Mid-infrared laser spectroscopy using a tunable gain-switched Cr2+: ZnSe laser, in Studierendentagung , Unversität zu Lübeck, 2013.
Mid-infrared laser spectroscopy using a tunable gain-switched Cr2+: ZnSe laser, in Studierendentagung , Unversität zu Lübeck, 2013.
Datei: | download |
Bibtex: | @inproceedings{Evers2013, author = {Evers, Michael and Welford, David and Manstein, Dieter and Birngruber, Reginald}, title = {Mid-infrared laser spectroscopy using a tunable gain-switched Cr2+: ZnSe laser}, booktitle = {Studierendentagung}, publisher = {Unversität zu Lübeck}, type = {Conference Proceedings}, URL = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.727.5163&rep=rep1&type=pdf}, year = { 2013} } |
Jens
Horstmann, and
Ralf
Brinkmann,
Non-contact photoacoustic tomography using holographic full field detection, Proc. SPIE, 2013. pp. 880007-880007-6.
Non-contact photoacoustic tomography using holographic full field detection, Proc. SPIE, 2013. pp. 880007-880007-6.
Datei: | 12.2033599 |
Bibtex: | @inproceedings{Horstmann2013, author = {Horstmann, Jens and Brinkmann, Ralf}, title = {Non-contact photoacoustic tomography using holographic full field detection}, publisher = {Proc. SPIE}, volume = {8800}, pages = {880007-880007-6}, note = {10.1117/12.2033599}, abstract = {An innovative very fast non-contact imaging technique for Photoacoustic Tomography is introduced. It is based on holographic optical speckle detection of a transiently altering surface topography for the reconstruction of absorbing targets. The surface movement is obtained by parallel recording of speckle phase changes known as Electronic Speckle Pattern Interferometry. Due to parallelized 2-D camera detection and repetitive excitation with variable delay with respect to the image acquisition, data recording of whole volumes for Photoacoustic Imaging can be completed in times far below one second. The size of the detected area is scalable by optical magnification. As a proof of concept, an interferometric setup is realized, capable of surface displacement detection with an axial resolution of less than 3 nm. The potential of the proposed method for in vivo Photoacoustic Imaging is discussed.}, url = {http://dx.doi.org/10.1117/12.2033599}, type = {Conference Proceedings}, year = { 2013} } |
Dominico
Klawitter,
Dierck
Hillmann,
Philipp
Steven, and
J
Wenzel,
Speckle variance optical coherence tomography for imaging microcirculation, in Studierendentagung , Universität zu Lübeck, 2013.
Speckle variance optical coherence tomography for imaging microcirculation, in Studierendentagung , Universität zu Lübeck, 2013.
Datei: | download |
Bibtex: | @inproceedings{Klawitter2013, author = {Klawitter, Dominico and Hillmann, Dierck and Pieper, M and Steven, Philipp and Wenzel, J and Hüttmann, Gereon}, title = {Speckle variance optical coherence tomography for imaging microcirculation}, booktitle = {Studierendentagung}, publisher = {Universität zu Lübeck}, type = {Conference Proceedings}, url = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.716.940&rep=rep1&type=pdf}, year = { 2013} } |
Peer K
Fink,
Dierck
Hillmann,
Gesa L
Franke,
Dirk
Ramm, and
P
Koch,
Stray light rejection by structured illumination, in Studierendentagung , Universität zu Lübeck, 2013.
Stray light rejection by structured illumination, in Studierendentagung , Universität zu Lübeck, 2013.
Eric
Seifert,
Young-Jung
Roh,
Andreas
Fritz,
Young Gun
Park,
Seungbum
Kang,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model, 2013. pp. 880303-880303-6.
Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model, 2013. pp. 880303-880303-6.
Datei: | 12.2033560 |
Bibtex: | @inproceedings{Seifert2013, author = {Seifert, Eric and Roh, Young-Jung and Fritz, Andreas and Park, Young Gun and Kang, Seungbum and Theisen-Kunde, Dirk and Brinkmann, Ralf}, title = {Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model}, volume = {8803}, pages = {880303-880303-6}, year = {2013}, note = {10.1117/12.2033560}, abstract = {Selective Retina Therapy (SRT) targets the Retinal Pigment Epithelium (RPE) without effecting neighboring layers as the photoreceptors or the choroid. SRT related RPE defects are ophthalmoscopically invisible. Owing to this invisibility and the variation of the threshold radiant exposure for RPE damage the treating physician does not know whether the treatment was successful or not. Thus measurement techniques enabling a correct dosing are a demanded element in SRT devices. The acquired signal can be used for monitoring or automatic irradiation control. Existing monitoring techniques are based on the detection of micro-bubbles. These bubbles are the origin of RPE cell damage for pulse durations in the ns and μs time regime 5μs. The detection can be performed by optical or acoustical approaches. Monitoring based on an acoustical approach has already been used to study the beneficial effects of SRT on diabetic macula edema and central serous retinopathy. We have developed a first real time feedback technique able to detect micro-bubble induced characteristics in the backscattered laser light fast enough to cease the laser irradiation within a burst. Therefore the laser energy within a burst of at most 30 pulses is increased linearly with every pulse. The laser irradiation is ceased as soon as micro-bubbles are detected. With this automatic approach it was possible to observe invisible lesions, an intact photoreceptor layer and a reconstruction of the RPE within one week.}, url = {http://dx.doi.org/10.1117/12.2033560}, type = {Conference Proceedings} } |
Alexander
Oepen,
Jens
Horstmann, and
Ralf
Brinkmann,
Characterization of an Electronic Speckle Pattern Detection System, in Studierendentagung , 2013.
Characterization of an Electronic Speckle Pattern Detection System, in Studierendentagung , 2013.
Felix
Fleischhauer,
Hinnerk
Schulz-Hildebrandt,
Tim
Bonin, and
Gereon
Hüttmann,
Polarization-sensitive optical coherence tomography on different tissues samples for tumor discrimination, in Studierendentagung , Universität zu Lübeck, 2013.
Polarization-sensitive optical coherence tomography on different tissues samples for tumor discrimination, in Studierendentagung , Universität zu Lübeck, 2013.
Datei: | a18366acff021e12dcc090b40890ea70dcb8.pdf |
Bibtex: | @inproceedings{Fleischhauer2013, author = {Fleischhauer, Felix and Schulz-Hildebrandt, Hinnerk and Bonin, Tim and Hüttmann, Gereon}, title = {Polarization-sensitive optical coherence tomography on different tissues samples for tumor discrimination}, booktitle = {Studierendentagung}, publisher = {Universität zu Lübeck}, type = {Conference Proceedings}, url = { https://pdfs.semanticscholar.org/a581/a18366acff021e12dcc090b40890ea70dcb8.pdf}, year = { 2013} } |
2012
Sebastian
Marschall,
Teresa
Torzicky,
Thomas
Klein,
Wolfgang
Wieser,
Michael
Pircher,
Erich
Götzinger,
Stefan
Zotter,
Marco
Bonesi,
Benjamin R.
Biedermann,
Christian
Pedersen,
Robert
Huber,
Christoph K.
Hitzenberger, and
Peter E.
Andersen,
High-speed polarization-sensitive OCT at 1060 nm using a Fourier domain mode-locked swept source, in Biophotonics: Photonic Solutions for Better Health Care III , Jürgen Popp and Wolfgang Drexler and Valery V. Tuchin and Dennis L. Matthews, Eds. SPIE, 052012. pp. 84271D.
High-speed polarization-sensitive OCT at 1060 nm using a Fourier domain mode-locked swept source, in Biophotonics: Photonic Solutions for Better Health Care III , Jürgen Popp and Wolfgang Drexler and Valery V. Tuchin and Dennis L. Matthews, Eds. SPIE, 052012. pp. 84271D.
DOI: | 10.1117/12.922313 |
Bibtex: | @inproceedings{10.1117/12.922313, author = {Sebastian Marschall and Teresa Torzicky and Thomas Klein and Wolfgang Wieser and Michael Pircher and Erich G{\"o}tzinger and Stefan Zotter and Marco Bonesi and Benjamin Biedermann and Christian Pedersen and Robert Huber and Christoph Hitzenberger and Peter Andersen}, title = {{High-speed polarization-sensitive OCT at 1060 nm using a Fourier domain mode-locked swept source}}, volume = {8427}, booktitle = {Biophotonics: Photonic Solutions for Better Health Care III}, editor = {J{\"u}rgen Popp and Wolfgang Drexler and Valery V. Tuchin and Dennis L. Matthews}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {84271D}, abstract = {Optical coherence tomography (OCT) in the 1060nm range is interesting for in vivo imaging of the human posterior eye segment (retina, choroid, sclera), as it permits a long penetration depth. Complementary to structural images, polarization-sensitive OCT (PS-OCT) images visualize birefringent, polarization-maintaining or depolarizing areas within the sample. This information can be used to distinguish retinal layers and structures with different polarization properties. High imaging speed is crucial for imaging ocular structures in vivo in order to minimize motion artifacts while acquiring sufficiently large datasets. Here, we demonstrate PS-OCT imaging at 350 kHz A-scan rate using a two-channel PS-OCT system in conjunction with a Fourier domain mode-locked laser. The light source spectrum spans up to 100nm around the water absorption minimum at 1060 nm. By modulating the laser pump current, we can optimize the spectrum and achieve a depth resolution of 9 μm in air (6.5 μm in tissue). We acquired retinal images in vivo with high resolution and deep penetration into choroid and sclera, and features like the depolarizing RPE or an increasing phase retardation at the chorio-scleral interface are clearly visualized.}, keywords = {optical coherence tomography, polarization-sensitive OCT, swept source, Fourier domain mode-locking, 1060 nm}, year = {2012}, doi = {10.1117/12.922313}, URL = {https://doi.org/10.1117/12.922313} } |
Wolfgang
Wieser,
Thomas
Klein,
Desmond C.
Adler,
Francois
Trepanier,
Sebastian
Karpf,
Christoph M.
Eigenwillig,
Joseph M.
Schmitt, and
Robert
Huber,
Dispersion Compensated Megahertz FDML Laser for Imaging of the Anterior Segment, in Conference on Lasers and Electro-Optics 2012 , Optica Publishing Group, 052012. pp. JTh3J.2.
Dispersion Compensated Megahertz FDML Laser for Imaging of the Anterior Segment, in Conference on Lasers and Electro-Optics 2012 , Optica Publishing Group, 052012. pp. JTh3J.2.
DOI: | 10.1364/CLEO_AT.2012.JTh3J.2 |
Bibtex: | @inproceedings{Wieser:12, author = {Wolfgang Wieser and Thomas Klein and Desmond C. Adler and Francois Tr\'{e}panier and Sebastian Karpf and Christoph M Eigenwillig and Joseph M. Schmitt and Robert Huber}, booktitle = {Conference on Lasers and Electro-Optics 2012}, journal = {Conference on Lasers and Electro-Optics 2012}, keywords = {Optical coherence tomography; Lasers, tunable; Optical coherence tomography; Fiber Bragg gratings; Fourier domain mode locking; Image quality; Laser modes; Mode locking; Optical coherence tomography}, pages = {JTh3J.2}, publisher = {Optica Publishing Group}, title = {Dispersion Compensated Megahertz FDML Laser for Imaging of the Anterior Segment}, year = {2012}, url = {https://opg.optica.org/abstract.cfm?URI=CLEO_AT-2012-JTh3J.2}, doi = {10.1364/CLEO_AT.2012.JTh3J.2}, abstract = {We present a Fourier domain mode locked laser at 1.6 MHz scan rate with greatly improved coherence length by reducing the laser cavity dispersion and the application of this laser in optical coherence tomography.}, } |
Sebastian
Marschall,
Thomas
Klein,
Wolfgang
Wieser,
Teresa
Torzicky,
Michael
Pircher,
Benjamin R.
Biedermann,
Christian
Pedersen,
Christoph K.
Hitzenberger,
Robert
Huber, and
Peter E.
Andersen,
Broadband Fourier domain mode-locked laser for optical coherence tomography at 1060 nm, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82130R.
Broadband Fourier domain mode-locked laser for optical coherence tomography at 1060 nm, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82130R.
DOI: | 10.1117/12.906148 |
Bibtex: | @inproceedings{10.1117/12.906148, author = {Sebastian Marschall and Thomas Klein and Wolfgang Wieser and Teresa Torzicky and Michael Pircher and Benjamin R. Biedermann and Christian Pedersen and Christoph K. Hitzenberger and Robert Huber and Peter E. Andersen}, title = {{Broadband Fourier domain mode-locked laser for optical coherence tomography at 1060 nm}}, volume = {8213}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI}, editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {82130R}, abstract = {Optical coherence tomography (OCT) in the 1060nm range is interesting for in vivo imaging of the human posterior eye segment (retina, choroid, sclera) due to low absorption in water and deep penetration into the tissue. Rapidly tunable light sources, such as Fourier domain mode-locked (FDML) lasers, enable acquisition of densely sampled three-dimensional datasets covering a wide field of view. However, semiconductor optical amplifiers (SOAs)-the typical laser gain media for swept sources-for the 1060nm band could until recently only provide relatively low output power and bandwidth. We have implemented an FDML laser using a new SOA featuring broad gain bandwidth and high output power. The output spectrum coincides with the wavelength range of minimal water absorption, making the light source ideal for OCT imaging of the posterior eye segment. With a moderate SOA current (270 mA) we achieve up to 100nm total sweep range and 12 μm depth resolution in air. By modulating the current, we can optimize the output spectrum and thereby improve the resolution to 9 μm in air (~6.5 μm in tissue). The average output power is higher than 20mW. Both sweep directions show similar performance; hence, both can be used for OCT imaging. This enables an A-scan rate of 350 kHz without buffering the light source output.}, keywords = {optical coherence tomography, tunable laser, swept source, Fourier domain mode-locking, broadband semiconductor optical amplifier}, year = {2012}, doi = {10.1117/12.906148}, URL = {https://doi.org/10.1117/12.906148} } |
Thomas
Klein,
Wolfgang
Wieser,
Raphael
André,
Tom
Pfeiffer,
Christoph M.
Eigenwillig, and
Robert
Huber,
Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82131E.
Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82131E.
DOI: | 10.1117/12.908798 |
Bibtex: | @inproceedings{10.1117/12.908798, author = {Thomas Klein and Wolfgang Wieser and Raphael Andr{\'e} and Tom Pfeiffer and Christoph M. Eigenwillig and Robert Huber}, title = {{Multi-MHz FDML OCT: snapshot retinal imaging at 6.7 million axial-scans per second}}, volume = {8213}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI}, editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {82131E}, abstract = {We demonstrate the acquisition of densely sampled wide-field 3D OCT datasets of the human retina in 0.3s. This performance is achieved with a multi-MHz Fourier domain mode-locked (FDML) laser source operating at 1050nm. A two-beam setup doubles the 3.35MHz laser sweep rate to 6.7MHz, which is 16x faster than results achieved with any non-FDML source used for retinal OCT. We discuss two main benefits of these high line rates: First, large datasets over an ultra-wide field of view can be acquired with a low probability of distortions. Second, even if eye movements occur, now the scan rate is high enough to directly correct even the fastest saccades without loss of information.}, keywords = {Optical coherence tomography, OCT, MHz OCT, Fourier-domain mode-locking, FDML, retinal imaging}, year = {2012}, doi = {10.1117/12.908798}, URL = {https://doi.org/10.1117/12.908798} } |
Cedric
Blatter,
Branislav
Grajciar,
Robert
Huber, and
Rainer
Leitgeb,
Deep skin structural and microcirculation imaging with extended-focus OCT, in Photonic Therapeutics and Diagnostics VIII , SPIE, 022012. pp. 82070B.
Deep skin structural and microcirculation imaging with extended-focus OCT, in Photonic Therapeutics and Diagnostics VIII , SPIE, 022012. pp. 82070B.
DOI: | 10.1117/12.909830 |
Bibtex: | @inproceedings{10.1117/12.909830, author = {Cedric Blatter and Branislav Grajciar and Robert Huber and Rainer A. Leitgeb}, title = {{Deep skin structural and microcirculation imaging with extended-focus OCT}}, volume = {8207}, booktitle = {Photonic Therapeutics and Diagnostics VIII}, editor = {Anita Mahadevan-Jansen and E. Duco Jansen and Andreas Mandelis and Kenton W. Gregory M.D. and Guillermo J. Tearney M.D. and Laura Marcu and Nikiforos Kollias and Bernard Choi and Haishan Zeng and Melissa J. Suter and Stephen Lam and Matthew Brenner and Hyun Wook Kang and Bodo E. Knudsen M.D. and Henry Hirschberg M.D. and Steen Madsen and Brian Jet-Fei Wong M.D. and Justus F. Ilgner M.D. and Krzysztof Izdebski}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {82070B}, abstract = {We present an extended focus OCT system for dermatologic applications that maintains high lateral resolution over a large depth range by using Bessel beam illumination. More, Bessel beams exhibit a self-reconstruction property that is particularly useful to avoid shadowing from surface structures such as hairs. High lateral resolution and high-speed measurement, thanks to a rapidly tuning swept source, allows not only for imaging of small skin structures in depth but also for comprehensive visualization of the small capillary network within the human skin in-vivo. We use this information for studying temporal vaso-responses to hypothermia. In contrast to other perfusion imaging methods such as laser Doppler imaging (LDI), OCT gives specific access to vascular responses in different vascular beds in depth.}, keywords = {Optical Coherence Tomography, FDML Swept Source, Extended focus, Bessel beam, Self-reconstruction property, Microcirculation imaging, Vasomechanics}, year = {2012}, doi = {10.1117/12.909830}, URL = {https://doi.org/10.1117/12.909830} } |
Desmond C.
Adler,
Wolfgang
Wieser,
Francois
Trepanier,
Joseph M.
Schmitt, and
Robert
Huber,
Coherence length extension of Fourier domain mode locked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82130O.
Coherence length extension of Fourier domain mode locked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82130O.
DOI: | 10.1117/12.908148 |
Bibtex: | @inproceedings{10.1117/12.908148, author = {Desmond C. Adler and Wolfgang Wieser and Francois Trepanier and Joseph M. Schmitt and Robert A. Huber}, title = {{Coherence length extension of Fourier domain mode locked lasers}}, volume = {8213}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI}, editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {82130O}, abstract = {Fourier domain mode locked (FDML) lasers provide high sweep rates, broad tuning ranges, and high output powers for optical coherence tomography (OCT) systems. However, presently-known FDML lasers at 1300 nm have relatively short coherence lengths, limiting the size of samples that can be imaged. Furthermore, FDML lasers produce only one useable sweep direction. We report FDML coherence length extension by incorporating advanced dispersion compensation modules (DCMs). DCMs eliminate group velocity dispersion in the cavity, doubling coherence lengths and ensuring uniform axial resolution over the imaging range. Additionally, forward and backward sweeps are nearly identical, removing the need for external buffering stages.}, keywords = {Fourier domain mode locked lasers, FDML, swept source, optical coherence tomography, dispersion compensation}, year = {2012}, doi = {10.1117/12.908148}, URL = {https://doi.org/10.1117/12.908148} } |
Cedric
Blatter,
Branislav
Grajciar,
Boris
Hermann,
Robert
Huber,
Wolfgang
Drexler, and
Rainer A.
Leitgeb,
Simultaneous dark-bright field swept source OCT for ultrasound detection, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82131M.
Simultaneous dark-bright field swept source OCT for ultrasound detection, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 022012. pp. 82131M.
DOI: | 10.1117/12.911443 |
Bibtex: | @inproceedings{10.1117/12.911443, author = {Cedric Blatter and Branislav Grajciar and Boris Hermann and Robert Huber and Wolfgang Drexler and Rainer A. Leitgeb}, title = {{Simultaneous dark-bright field swept source OCT for ultrasound detection}}, volume = {8213}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI}, editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {82131M}, abstract = {We introduce a swept source FDOCT imaging system that allows measuring simultaneously the reflected light and scattered light (bright field) and the scattered light only (dark field) in two different channels through separate Gaussian and Bessel detection. Specular reflections can then be used to obtain knowledge about the sample time evolution with high SNR for phase analysis. Based on this configuration, we provide a proof-of principle study for resolving ultrasound pulse trains with high temporal resolution on surfaces, which potentially provides a novel phase sensitive all optical detection scheme for the combination of OCT with photoacoustic imaging.}, keywords = {Dark field imaging, Bessel beam, Extended focus, FDML Swept Source, Multichannel detection, Photoacoustic, Ultrasound, Phase sensitive}, year = {2012}, doi = {10.1117/12.911443}, URL = {https://doi.org/10.1117/12.911443} } |