Publikationen 2018 - 2019

2018

  • Matthias Eibl, Daniel Weng, Hubertus Hakert, Jan Philip Kolb, Tom Pfeiffer, Jennifer E. Hundt, Robert Huber and Sebastian Karpf: Wavelength agile multi-photon microscopy with a fiber amplified diode laser. Biomedical Optics Express, no. 9, pp. 6273-6282, 2018
    BibTeX Link
    @article{Eibl2018,
    author = {Matthias Eibl, Daniel Weng, Hubertus Hakert, Jan Philip Kolb, Tom Pfeiffer, Jennifer E. Hundt, Robert Huber and Sebastian Karpf},
    title = {Wavelength agile multi-photon microscopy with a fiber amplified diode laser},
    journal = {Biomedical Optics Express},
    keywords = {NLI, TPEF, Multiphoton},
    volume = {9},
    number = {12},
    pages = {6273--6282},
    doi = {10.1364/BOE.9.006273},
    }
    
  • Pfeiffer, Tom / Petermann, Markus /Draxinger, Wolfgang / Jirauschek, Christian and Huber, Robert: Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography. Biomedical Optics Express, no. 9, pp. 4130-4148, 2018
    BibTeX Link Link
    @article{Pfeiffer2018,
       author = {Pfeiffer, Tom / Petermann, Markus /Draxinger, Wolfgang / Jirauschek, Christian and Huber, Robert},
       title = {Ultra low noise Fourier domain mode locked laser for high quality magahertz optical coherence tomography},
       journal = {Biomedical Optics Express},
       volume = {9},
       number = {9},
       pages = {4130-4148},
        DOI = {10.1364/BOE.9.004130},
    url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052736688&doi=10.1364%2fBOE.9.004130&partnerID=40&md5=1ed100666a2d806f51b68e70ba13808c}
       year = {2018},
       type = {Journal Article}
    }
    
  • Miura, Yoko: Two-Photon Microscopy (TPM) and Fluorescence Lifetime Imaging Microscopy (FLIM) of Retinal Pigment Epithelium (RPE) of Mice In Vivo. in Mouse Retinal Phenotyping: Methods and Protocols, pp. 73-88, Springer New York, New York, NY, 2018
    BibTeX Link
    @inbook{Miura2018,
       author = {Miura, Yoko},
       title = {Two-Photon Microscopy (TPM) and Fluorescence Lifetime Imaging Microscopy (FLIM) of Retinal Pigment Epithelium (RPE) of Mice In Vivo},
       booktitle = {Mouse Retinal Phenotyping: Methods and Protocols},
       editor = {Tanimoto, Naoyuki},
       publisher = {Springer New York},
       address = {New York, NY},
       pages = {73-88},
       ISBN = {978-1-4939-7720-8},
       url={https://doi.org/10.1007/978-1-4939-7720-8_5},
       year = {2018},
       type = {Book Section}
    }
    
  • Tode, J. and Richert, E. and Koinzer, S. and Klettner, A. and von der Burchard, C. and Brinkmann, R. and Lucius, R. and Roider, J.: Thermal Stimulation of the Retina Reduces Bruch`s Membrane Thickness in Age Related Macular Degeneration Mouse Models. Transl Vis Sci Technol, no. 7, pp. 2, 2018
    BibTeX Link
    @article{Tode2018,
       author = {Tode, J. and Richert, E. and Koinzer, S. and Klettner, A. and von der Burchard, C. and Brinkmann, R. and Lucius, R. and Roider, J.},
       title = {Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models},
       journal = {Transl Vis Sci Technol},
       volume = {7},
       number = {3},
       pages = {2},
       ISSN = {2164-2591 (Print)
    2164-2591 (Linking)}, 
       url = {https://www.ncbi.nlm.nih.gov/pubmed/29736323},
       year = {2018},
       type = {Journal Article}
    }
    
  • C. Herzog and O. Thompson and B. Schmarbeck and M. Siebert and Brinkmann, R.: Temperature-controlled laser therapy of the retina via robust adaptive Ɦ∞-control. De Gruyter, no. 66 (12), pp. 1051-1063, 2018
    BibTeX Link
    @article{Brinkmann2018,
       author = {C. Herzog and O. Thompson and B. Schmarbeck and M. Siebert and Brinkmann, R.},
       title = {Temperature-controlled laser therapy of the retina via robust adaptive Ɦ∞-control},
       journal = {De Gruyter},
       volume = {66 (12)},
       pages = {1051-1063},
       DOI = {https://www.degruyter.com/view/j/auto.2018.66.issue-12/auto-2018-0066/auto-2018-0066.xml},
       year = {2018},
       type = {Journal Article},
    keywords = {Laser therapy; robust control; parameter estimation; photoacoustics; real-time temperature determination},
       abstract = {Recent studies demonstrate therapeutic benefits in retinal laser therapy even for non-visible effects of the irradiation. However, in practice, ophthalmologists often rely on the visual inspection of irradiation sites to manually set the laser power for subsequent ones. Since absorption properties vary strongly between sites, this procedure can lead to under- or over-treatment. To achieve safe automatic retinal laser therapy, this article proposes a robust control scheme based on photoacoustic feedback of the retinal temperature increase. The control scheme is further extended to adapt to real-time parameter estimates and associated bounds on the uncertainty of each irradiation site. Both approaches are successfully validated in ex vivo experiments on pigs’ eyes, achieving consistent irradiation durations of 55 ms despite the uncertainty in absorption properties.}
    }
    
  • Gianni Borghesan and Mouloud Ourak and Eva Lankenau and Gereon Hüttmann and Hinnerk Schulz-Hildebrandt and Koen Willekens and Peter Stalmans and Dominiek Reynaerts and Emmanuel Vander Poorten: Single Scan OCT-based Retina Detection for Robot-assisted Retinal Vein Cannulation. Journal of Medical Robotics Research, no. 3, pp. 184005, 2018
    BibTeX Link Link
    @article{borghesan2018single,
    title = {Single Scan OCT-based Retina Detection for Robot-assisted Retinal Vein Cannulation},
    author = {Gianni Borghesan and Mouloud Ourak and Eva Lankenau and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt and Koen Willekens and Peter Stalmans and Dominiek Reynaerts and Emmanuel Vander Poorten},
    editor = {World Scientific},
    url = {https://www.worldscientific.com/doi/abs/10.1142/S2424905X18400056},
    doi = {10.1142/S2424905X18400056},
    year = {2018},
    date = {2018-02-12},
    journal = {Journal of Medical Robotics Research},
    volume = {3},
    number = {02},
    pages = {184005},
    abstract = {Vitreoretinal surgery concerns a set of particularly demanding minimal invasive micro-surgical interventions at the retina. Micro-surgeons are targeting sub-millimeter-sized structures here. Tiny vessels or wafer-thin membranes are to be cannulated or need to be peeled off. The greatest care is to be displayed not to damage these fragile structures or to inadvertently injure the underlying retina. Damage to the latter is mostly irreparable and might cause permanent loss of vision. Despite the availability over excellent stereo microscopes, wide-angle lenses and powerful light source visualization remains a problem. Especially, the limited depth perception is still perceived as a major bottle-neck whereas efforts have been conducted to integrate sensing capability in today’s state-of-the-art instruments, so far, little effort has been paid to process the obtained sensor data and turns this into a reliable source of information upon which robot assistive guidance schemes could be endowed upon. This paper proposes a number of processing techniques tailored to Optical Coherence Tomography (OCT) measurements. The first results of the proposed algorithms show that it is feasible to extract good and reliable distance estimates from this otherwise rather noisy signal and from a fairly limited dataset. The used data are the so-called A-scans. These are OCT measurements consisting of a single-line image that could be captured by an instrument-mounted fiber through which the OCT signal passes back-and-forth. However, in this work, we perform a pilot study whereby the employed A-scans are extracted from B-scans that are captured by a microscope-mounted OCT scanner, rather than obtained from a probe. The performance of a first embodiment of the algorithm that is based on an Unscented Kalman Filter (UKF) is compared to the performance of a second embodiment that relies on a Particle Filter (PF), focusing on the issues in filter initialization and the tracking quality. Finally, results of UKF and PF executions on a validation dataset are presented. 
    Read More: https://www.worldscientific.com/doi/abs/10.1142/S2424905X18400056},
    keywords = {Endoskope},
    pubstate = {published},
    tppubtype = {article}
    }
  • Sudkamp, Helge and Hillmann, Dierck and Koch, Peter and Endt, Malte vom and Spahr, Hendrik and Münst, Michael and Pfäffle, Clara and Birngruber, Reginald and Hüttmann, Gereon: Simple approach for aberration-corrected OCT imaging of the human retina. Optics Letters, no. 43, pp. 4224, 2018
    BibTeX Link
    @article{Sudkamp2018a,
       author = {Sudkamp, Helge and Hillmann, Dierck and Koch, Peter and Endt, Malte vom and Spahr, Hendrik and Münst, Michael and Pfäffle, Clara and Birngruber, Reginald and Hüttmann, Gereon},
       title = {Simple approach for aberration-corrected OCT imaging of the human retina},
       journal = {Optics Letters},
       volume = {43},
       number = {17},
       pages = {4224},
       ISSN = {0146-9592
    1539-4794},
       DOI = {10.1364/ol.43.004224},
       year = {2018},
       type = {Journal Article},
       keyword = {Retome}
    }
    
  • Seifert, E. and Tode, J. and Pielen, A. and Theisen-Kunde, D. and Framme, C. and Roider, J. and Miura, Y. and Birngruber, R. and Brinkmann, R.: Selective retina therapy: toward an optically controlled automatic dosing. J Biomed Opt, no. 23, pp. 1-12, 2018
    BibTeX Link Link
    @article{seifert2018,
       author = {Seifert, E. and Tode, J. and Pielen, A. and Theisen-Kunde, D. and Framme, C. and Roider, J. and Miura, Y. and Birngruber, R. and Brinkmann, R.},
       title = {Selective retina therapy: toward an optically controlled automatic dosing},
       journal = {J Biomed Opt},
       volume = {23},
       number = {11},
       pages = {1-12},
       ISSN = {1560-2281 (Electronic)
    1083-3668 (Linking)},
       DOI = {10.1117/1.JBO.23.11.115002},   
    keywords = {algorithm, lasers in medicine, ophthalmology, retinal pigment epithelium, selective retina therapy, selectivity}
       year = {2018},
       type = {Journal Article}
    }
    
  • Richert, Elisabeth and Koinzer, Stefan and Tode, Jan and Schlott, Kerstin and Brinkmann, Ralf and Hillenkamp, Jost and Klettner, Alexa and Roider, Johann: Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy. Investigative Ophthalmology & Visual Science, no. 59, pp. 1323-1331, 2018
    BibTeX Link
    @article{Richert2018,
       author = {Richert, Elisabeth and Koinzer, Stefan and Tode, Jan and Schlott, Kerstin and Brinkmann, Ralf and Hillenkamp, Jost and Klettner, Alexa and Roider, Johann},
       title = {Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {59},
       number = {3},
       pages = {1323-1331},
       ISSN = {1552-5783},
       DOI = {10.1167/iovs.17-23163},
       
       year = {2018},
       type = {Journal Article}
    }
    
  • Richert, Elisabeth and Koinzer, Stefan and Tode, Jan and Schlott, Kerstin and Brinkmann, Ralf and Hillenkamp, Jost and Klettner, Alexa and Roider, Johann: Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy. Investigative Ophthalmology & Visual Science, no. 59, pp. 1323-1331, 2018
    BibTeX Link Link
    @article{RN5023,
       author = {Richert, Elisabeth and Koinzer, Stefan and Tode, Jan and Schlott, Kerstin and Brinkmann, Ralf and Hillenkamp, Jost and Klettner, Alexa and Roider, Johann},
       title = {Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {59},
       number = {3},
       pages = {1323-1331},
       ISSN = {1552-5783},
       DOI = {10.1167/iovs.17-23163},
       url = {http://dx.doi.org/10.1167/iovs.17-23163},
       year = {2018},
       type = {Journal Article}
    }
    
  • Malte Casper and Hinnerk Schulz-Hildebrandt and Michael Evers and Reginald Birngruber and Dieter Manstein and Gereon Hüttmann: Optimized segmentation and characterization of capillary networks using OCT (Conference Presentation). Proc.SPIE, in Proc. SPIE 10467, Photonics in Dermatology and Plastic Surgery 2018, no. 10467, 2018
    BibTeX Link Link
    @conference{Casper2018,
    title = {Optimized segmentation and characterization of capillary networks using OCT (Conference Presentation)},
    author = {Malte Casper and Hinnerk Schulz-Hildebrandt and Michael Evers and Reginald Birngruber and Dieter Manstein and Gereon H\"{u}ttmann},
    url = {https://doi.org/10.1117/12.2292005},
    doi = {10.1117/12.2292005},
    year = {2018},
    date = {2018-03-14},
    booktitle = {Proc. SPIE 10467, Photonics in Dermatology and Plastic Surgery 2018},
    journal = {Proc.SPIE},
    volume = {10467},
    abstract = {The ability to image the physiology of microvasculature with high spatial resolution in three dimensions while investigating structural changes of skin, is essential for understanding the complex processes of skin aging, wound healing and disease development. Further, the quantitative, automatic assessment of these changes enables to analyze large amounts of image data in an abstract but comprehensive manner. 
    However, previous work using OCT with methods of angiography was imaging less scattering, hence more challenging tissue than skin, such as brain and retina tissue. The published methods for capillary segmentation were mostly non-automatic, poorly benchmarked against state-of-the-art methods of computer vision and not applied to investigate medical processes and studies in a comprehensive fashion. 
    Here, segmentation of capillaries in skin is reported and its efficacy is demonstrated in both, a 
    longitudinal mouse study and a preliminary study in humans. By combining state-of-the-art image 
    processing methods in an optimized way, we were able to improve the segmentation results and analyze the impact of each post-processing step. 
    Furthermore, this automatic segmentation enabled us to analyze big amounts of 
    datasets automatically and derive meaningful conclusions for the planning of clinical studies. 
    With this work, optical coherence tomography is combined with methods of computer vision to a diagnostic 
    tool with unique capabilities to characterize vascular diversity and provide extraordinary 
    opportunities for dermatological investigation in both, clinics and research.},
    keywords = {},
    pubstate = {published},
    tppubtype = {conference}
    }
  • Hinnerk Schulz-Hildebrandt and Mario Pieper and Charlotte Stehmar and Martin Ahrens and Christian Idel and Barbara Wollenberg and Peter König and Gereon Hüttmann: Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography. Biomedical Optics Express, no. 9, pp. 636-647, 2018
    BibTeX Link Link
    @article{schulz2018novel,
    title = {Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography},
    author = {Hinnerk Schulz-Hildebrandt and Mario Pieper and Charlotte Stehmar and Martin Ahrens and Christian Idel and Barbara Wollenberg and Peter K\"{o}nig and Gereon H\"{u}ttmann},
    editor = {Optical Society of America},
    url = {https://www.osapublishing.org/abstract.cfm?URI=boe-9-2-636
    https://www.osapublishing.org/boe/viewmedia.cfm?uri=boe-9-2-636&seq=0},
    doi = {10.1364/BOE.9.000636},
    isbn = {10.1364/BOE.9.000636},
    year = {2018},
    date = {2018-01-16},
    journal = {Biomedical Optics Express},
    volume = {9},
    number = {2},
    pages = {636-647},
    abstract = {Intravital microscopy (IVM) offers the opportunity to visualize static and dynamic changes of tissue on a cellular level. It is a valuable tool in research and may considerably improve clinical diagnosis. In contrast to confocal and non-linear microscopy, optical coherence tomography (OCT) with microscopic resolution (mOCT) provides intrinsically cross-sectional imaging. Changing focus position is not needed, which simplifies especially endoscopic imaging. For in-vivo imaging, here we are presenting endo-microscopic OCT (emOCT). A graded-index-lens (GRIN) based 2.75 mm outer diameter rigid endoscope is providing 1.5 \textendash 2 μm nearly isotropic resolution over an extended field of depth. Spherical and chromatic aberrations are used to elongate the focus length. Simulation of the OCT image formation, suggests overall a better image quality in this range compared to a focused Gaussian beam. Total imaging depth at a reduced sensitivity and lateral resolution is more than 200 μm. Using a frame rate of 80 Hz cross-sectional images of concha nasalis were demonstrated in humans, which could resolve cilial motion, cellular structures of the epithelium, vessels and blood cells. Mucus transport velocity was determined successfully. The endoscope may be used for diagnosis and treatment control of different lung diseases like cystic fibrosis or primary ciliary dyskinesia, which manifest already at the nasal mucosa.},
    keywords = {Endoskope, OCM},
    pubstate = {published},
    tppubtype = {article}
    }
  • Hendrik Spahr and Clara Pfäffle and Peter Koch and Helge Sudkamp and Gereon Hüttmann and Dierck Hillmann: Interferometric detection of 3D motion using computational subapertures in optical coherence tomography. Opt. Express, no. 26, pp. 18803-18816, OSA, Jul, 2018
    BibTeX Link Link
    @article{Spahr:18,
    author = {Hendrik Spahr, Clara Pfäffle, Peter Koch, Helge Sudkamp, Gereon Hüttmann und Dierck Hillmann},
    journal = {Opt. Express},
    keywords = {Funktion, Fullfield},
    number = {15},
    pages = {18803--18816},
    publisher = {OSA},
    title = {Interferometric detection of 3D motion using computational subapertures in optical coherence tomography},
    volume = {26},
    month = {Jul},
    year = {2018},
    url = {http://www.opticsexpress.org/abstract.cfm?URI=oe-26-15-18803},
    doi = {10.1364/OE.26.018803},
    abstract = {Doppler optical coherence tomography (OCT) quantifies axial motion with high precision, whereas lateral motion cannot be detected by a mere evaluation of phase changes. This problem was solved by the introduction of three-beam Doppler OCT, which, however, entails a high experimental effort. Here, we present the numerical analogue to this experimental approach. Phase-stable complex-valued OCT datasets, recorded with full-field swept-source OCT, are filtered in the Fourier domain to limit imaging to different computational subapertures. These are used to calculate all three components of the motion vector with interferometric precision. As known from conventional Doppler OCT for axial motion only, the achievable accuracy exceeds the actual imaging resolution by orders of magnitude in all three dimensions. The feasibility of this method is first demonstrated by quantifying micro-rotation of a scattering sample. Subsequently, a potential application is explored by recording the 3D motion vector field of tissue during laser photocoagulation in ex-vivo porcine retina.},
    }
    
    
  • Uzunbajakava, N. E. and Varghese, B. and Botchkareva, N. V. and Verhagen, R. and Vogel, A.: Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE, no. 0492 ,, 2018
    BibTeX Link
    @inproceedings{Vogel2018,
       author = {Uzunbajakava, N. E. and Varghese, B. and Botchkareva, N. V. and Verhagen, R. and Vogel, A.},
       title = {Highlighting the nuances behind interaction of picosecond pulses with human skin: Relating distinct laser-tissue interactions to their potential in cutaneous interventions},
       booktitle = {Progress in Biomedical Optics and Imaging - Proceedings of SPIE},
       volume = {10492} ,
       DOI = {10.1117/12.2307804}
       year = {2018}
    date = {2018-20-02},
       type = {Conference Proceedings}
    }
  • Hinnerk Schulz-Hildebrandt /Tom Pfeiffer /Tim Eixmann /Sabrina Lohmann /Martin Ahrens /Josua Rehra /Wolfgang Draxinger /Peter König /Robert Huber and Gereon Hüttmann: High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography. Optics Letters, no. 43, pp. 4386-4389, 2018
    BibTeX Link Link
    @article{Schulz-Hildebrandt2018b,
    title = {High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography},
    author = {Hinnerk Schulz-Hildebrandt /Tom Pfeiffer /Tim Eixmann /Sabrina Lohmann /Martin Ahrens /Josua Rehra /Wolfgang Draxinger /Peter K\"{o}nig /Robert Huber and Gereon H\"{u}ttmann},
    url = {ttp://ol.osa.org/abstract.cfm?URI=ol-43-18-4386},
     DOI = {10.1364/OL.43.004386},
    
    year = {2018},
    date = {2018-09-05},
    journal = {Optics Letters},
    volume = {43},
    number = {18},
    pages = {4386-4389},
    abstract = {We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 μm was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in spirals for scanning the sample, the beam quality remains constant over the entire field of view with a diameter of 0.8 mm. The scanning frequency was adjusted to 1.22 kHz for use with a 3.28 MHz Fourier domain mode locked OCT system. Densely sampled volumes have been imaged at a rate of 6 volumes per second.
    
    © 2018 Optical Society of America},
    keywords = {Endoskope},
    pubstate = {published},
    tppubtype = {article}
    }
  • Kolb, Jan Philip and Pfeiffer, Tom and Eibl, Matthias and Hakert, Hubertus and Huber, Robert: High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates. Biomedical Optics Express, no. 9, pp. 120-130, 2018
    BibTeX Link
    @article{Kolb2018,
       author = {Kolb, Jan Philip and Pfeiffer, Tom and Eibl, Matthias and Hakert, Hubertus and Huber, Robert},
       title = {High-resolution retinal swept source optical coherence tomography with an ultra-wideband Fourier-domain mode-locked laser at MHz A-scan rates},
       journal = {Biomedical Optics Express},
       volume = {9},
       number = {1},
       pages = {120-130},
       DOI = {10.1364/BOE.9.000120},
       year = {2018},
       type = {Journal Article}
    }
    
  • Kern, K. and Mertineit, C. L. and Brinkmann, R. and Miura, Y.: Expression of heat shock protein 70 and cell death kinetics after different thermal impacts on cultured retinal pigment epithelial cells. Exp Eye Res, no. 170, pp. 117-126, 2018
    BibTeX Link
    @article{Miura2018,
       author = {Kern, K. and Mertineit, C. L. and Brinkmann, R. and Miura, Y.},
       title = {Expression of heat shock protein 70 and cell death kinetics after different thermal impacts on cultured retinal pigment epithelial cells},
       journal = {Exp Eye Res},
       volume = {170},
       pages = {117-126},
       ISSN = {1096-0007 (Electronic)
    0014-4835 (Linking)},
       DOI = {10.1016/j.exer.2018.02.013},
       year = {2018},
       type = {Journal Article}
    }
    
  • Evers, M. and Salma, N. and Osseiran, S. and Casper, M. and Birngruber, R. and Evans, C. L. and Manstein, D.: Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM. Scientific Reports, no. 8, 2018
    BibTeX Link
    @article{Evers2018,
       author = {Evers, M. and Salma, N. and Osseiran, S. and Casper, M. and Birngruber, R. and Evans, C. L. and Manstein, D.},
       title = {Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM},
       journal = {Scientific Reports},
       volume = {8},
       number = {1},
       DOI = {10.1038/s41598-018-27093-x},
       
       year = {2018},
       type = {Journal Article}
    }
    
  • Jonas Smits and Mouloud Ourak and Andy Gijbels and Laure Esteveny and Gianni Borghesan and Laurent Schoevaerdts and K. Willekens P. Stalmans E. Lankenau Hinnerk Schulz-Hildebrandt and Gereon Hüttmann and Dominiek Reynaerts and Emmanuel B. Vander Poorten: Development and Experimental Validation of a Combined FBG Force and OCT Distance Sensing Needle for Robot-Assisted Retinal Vein Cannulation. 2018 IEEE International Conference on Robotics and Automation (ICRA), pp. 129-134, 2018
    BibTeX Link Link
    @inproceedings{Smits2018,
    title = {Development and Experimental Validation of a Combined FBG Force and OCT Distance Sensing Needle for Robot-Assisted Retinal Vein Cannulation},
    author = {Jonas Smits and Mouloud Ourak and Andy Gijbels and Laure Esteveny and Gianni Borghesan and Laurent Schoevaerdts and K. Willekens P. Stalmans E. Lankenau Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Dominiek Reynaerts and Emmanuel B. Vander Poorten},
    
    doi = {10.1109/ICRA.2018.8460983},
    year = {2018},
    date = {2018-09-20},
    journal = {2018 IEEE International Conference on Robotics and Automation (ICRA)},
    pages = {129-134},
    abstract = {Retinal Vein Occlusion is a common retinal vascular disorder which can cause severe loss of vision. Retinal vein cannulation followed by injection of an anti-coagulant into the affected vein is a promising treatment. However, given the scale and fragility of the surgical workfield, this procedure is considered too high-risk to perform manually. A first successful robot-assisted procedure has been demonstrated. Even though successful, the procedure remains extremely challenging. This paper aims at providing a solution for the limited perception of instrument-tissue interaction forces as well as depth estimation during retinal vein cannulation. The development of a novel combined force and distance sensing cannulation needle relying on Fiber Bragg grating (FBG) and Optical Coherence Tomography (OCT) A-scan technology is reported. The design, the manufacturing process, the calibration method, and the experimental characterization of the produced sensor are discussed. 
    The functionality of the combined sensing modalities and the real-time distance estimation algorithm are validated respectively on in-vitro and ex-vivo models.},
    keywords = {Endoskope},
    pubstate = {published},
    tppubtype = {inproceedings}
    }
  • Han, J. W. and Choi, J. / Kim, Y. S. and Kim, J. / Brinkmann, R. / Lyu, J. and Park, T. K.: Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes. Graefe`s Archive for Clinical and Experimental Ophthalmology, no. 256, pp. 341-353, 2018
    BibTeX Link
    @article{Brinkmann2018,
       author = {Han, J. W. and Choi, J. / Kim, Y. S. and Kim, J. / Brinkmann, R. / Lyu, J. and Park, T. K.},
       title = {Comparison of the neuroinflammatory responses to selective retina therapy and continuous-wave laser photocoagulation in mouse eyes},
       journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
       volume = {256},
       number = {2},
       pages = {341-353},
     
    URL= {https://doi.org/10.1007/s00417-017-3883-7},
       year = {2018},
       type = {Journal Article}
    }
    
  • Ourak, M. and Smits, J. and Esteveny, L. and Borghesan, G. and Gijbels, A. and Schoevaerdts, L. and Douven, Y. and Scholtes, J. and Lankenau, E. and Eixmann, T. and Schulz-Hildebrandt, Hinnerk and Hüttmann, Gereon and Kozlovszky, M. and Kronreif, G. and Willekens, K. and Stalmans, P. and Faridpooya, K. and Cereda, M. and Giani, A. and Staurenghi, G. and Reynaerts, D. and Vander Poorten, E. B.: Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation. International Journal of Computer Assisted Radiology and Surgery, no. 13, pp. 1-9, 2018
    BibTeX Link Link
    @article{Ourak2018,
    title = {Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation},
    author = {Ourak, M. and Smits, J. and Esteveny, L. and Borghesan, G. and Gijbels, A. and Schoevaerdts, L. and Douven, Y. and Scholtes, J. and Lankenau, E. and Eixmann, T. and Schulz-Hildebrandt, Hinnerk and H\"{u}ttmann, Gereon and Kozlovszky, M. and Kronreif, G. and Willekens, K. and Stalmans, P. and Faridpooya, K. and Cereda, M. and Giani, A. and Staurenghi, G. and Reynaerts, D. and Vander Poorten, E. B.},
    
    doi = {10.1007/s11548-018-1829-0},
    year = {2018},
    date = {2018-07-28},
    journal = {International Journal of Computer Assisted Radiology and Surgery},
    volume = {13},
    number = {107},
    pages = {1-9},
    keywords = {Endoskope},
    pubstate = {published},
    tppubtype = {article}
    }
  • Maertz, J. and Kolb, J. P. and Klein, T. and Mohler, K. J. and Eibl, M. and Wieser, W. and Huber, R. and Priglinger, S. and Wolf, A.: Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm. Graefe`s Archive for Clinical and Experimental Ophthalmology, no. 256, pp. 289-298, 2018
    BibTeX Link Link
    @article{Maertz2018,
       author = {Maertz, J. and Kolb, J. P. and Klein, T. and Mohler, K. J. and Eibl, M. and Wieser, W. and Huber, R. and Priglinger, S. and Wolf, A.},
       title = {Combined in-depth, 3D, en face imaging of the optic disc, optic disc pits and optic disc pit maculopathy using swept-source megahertz OCT at 1050 nm},
       journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
       volume = {256},
       number = {2},
       pages = {289-298},
       DOI = {10.1007/s00417-017-3857-9},
       url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032262413&doi=10.1007%2fs00417-017-3857-9&partnerID=40&md5=a46c315f12cf5e633ea0f7e644116eb3},
       year = {2018},
       Keywords= {En face imaging, Optical coherence tomography, Swept-source OCT, Megahertz OCT, 3D rendering, Optic disc, Optic disc pit, Optic disc pit maculopathy}
       type = {Journal Article}
    }
  • Hinnerk Schulz-Hildebrandt and Michael Münter and Martin Ahrens and Hendrik Spahr and Dierck Hillmann and Peter König and Gereon Hüttmann: Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations. in 2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources, no. 10591, pp. 105910O, 2018
    BibTeX Link
    @inproceedings{Schulz-Hildebrandt2018a,
    title = {Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations},
    author = {Hinnerk Schulz-Hildebrandt and Michael M\"{u}nter and Martin Ahrens and Hendrik Spahr and Dierck Hillmann and Peter K\"{o}nig and Gereon H\"{u}ttmann},
    doi = {10.1117/12.2303755},
    isbn = {9781510616745},
    year = {2018},
    date = {2018-03-05},
    booktitle = {2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources},
    volume = {10591},
    pages = {105910O},
    abstract = {Optical coherence tomography (OCT) images scattering tissues with 5 to 15 μm resolution. This is usually not sufficient for a distinction of cellular and subcellular structures. Increasing axial and lateral resolution and compensation of artifacts caused by dispersion and aberrations is required to achieve cellular and subcellular resolution. This includes defocus which limit the usable depth of field at high lateral resolution. OCT gives access the phase of the scattered light and hence correction of dispersion and aberrations is possible by numerical algorithms. Here we present a unified dispersion/aberration correction which is based on a polynomial parameterization of the phase error and an optimization of the image quality using Shannon’s entropy. For validation, a supercontinuum light sources and a costume-made spectrometer with 400 nm bandwidth were combined with a high NA microscope objective in a setup for tissue and small animal imaging. Using this setup and computation corrections, volumetric imaging at 1.5 μm resolution is possible. Cellular and near cellular resolution is demonstrated in porcine cornea and the drosophila larva, when computational correction of dispersion and aberrations is used. Due to the excellent correction of the used microscope objective, defocus was the main contribution to the aberrations. In addition, higher aberrations caused by the sample itself were successfully corrected. Dispersion and aberrations are closely related artifacts in microscopic OCT imaging. Hence they can be corrected in the same way by optimization of the image quality. This way microscopic resolution is easily achieved in OCT imaging of static biological tissues.},
    keywords = {OCM},
    pubstate = {published},
    tppubtype = {inproceedings}
    }
  • Evers, M. and Ha, L. and Casper, M. and Welford, D. and Kositratna, G. and Birngruber, R. and Manstein, D.: Assessment of skin lesions produced by focused, tunable, mid-infrared chalcogenide laser radiation. Lasers in Surgery and Medicine, 2018
    BibTeX Link
    @article{Evers2018
       author = {Evers, M. and Ha, L. and Casper, M. and Welford, D. and Kositratna, G. and Birngruber, R. and Manstein, D.},
       title = {Assessment of skin lesions produced by focused, tunable, mid-infrared chalcogenide laser radiation},
       journal = {Lasers in Surgery and Medicine},
       DOI = {10.1002/lsm.22935},
      
       year = {2018},
       type = {Journal Article}
    }