2002 - 2000

2002

  • Hoerauf, H. and Scholz, C. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.: Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye. Arch Ophthalmol, no. 120, pp. 816-9, 2002
    BibTeX
    @article{Hoerauf2002,
       author = {Hoerauf, H. and Scholz, C. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.},
       title = {Transscleral optical coherence tomography: a new imaging method for the anterior segment of the eye},
       journal = {Arch Ophthalmol},
       volume = {120},
       number = {6},
       pages = {816-9},
       note = {0003-9950 (Print)
    Journal Article},
       abstract = {OBJECTIVE: To present a new imaging method for the anterior segment of the eye. METHODS: Transscleral optical coherence tomographic images were generated in healthy volunteers using a slitlamp-adapted prototype equipped with a superluminescence diode with an infrared wavelength of 1310 nm. RESULTS: The optical coherence tomographic system used allowed penetration of human sclera in vivo and high-resolution, cross-sectional imaging of the anterior chamber angle and the ciliary body. CONCLUSION: The 1310-nm optical coherence tomographic image shows a significant potential as a noninvasive diagnostic tool for the anterior segment of the eye.},
       keywords = {Anatomy, Cross-Sectional/*methods
    Anterior Eye Segment/*anatomy & histology
    *Diagnostic Techniques, Ophthalmological
    Humans
    Interferometry
    Light
    Sclera
    Tomography/methods},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12049589},
       year = {2002},
       type = {Journal Article}
    }
    
  • Hoerauf, H. and Winkler, J. and Scholz, C. and Wirbelauer, C. and Gordes, R. S. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.: Transscleral optical coherence tomography-an experimental study in ex-vivo human eyes. Lasers Surg Med, no. 30, pp. 209-15, 2002
    BibTeX
    @article{Hoerauf2002,
       author = {Hoerauf, H. and Winkler, J. and Scholz, C. and Wirbelauer, C. and Gordes, R. S. and Koch, P. and Engelhardt, R. and Laqua, H. and Birngruber, R.},
       title = {Transscleral optical coherence tomography--an experimental study in ex-vivo human eyes},
       journal = {Lasers Surg Med},
       volume = {30},
       number = {3},
       pages = {209-15},
       note = {0196-8092 (Print)
    Journal Article},
       abstract = {BACKGROUND AND OBJECTIVE: To evaluate the potentials of a 1310-nm optical coherence tomography (OCT) system to penetrate the highly backscattering sclera in enucleated human eyes and provide visualization of intraocular structures by transscleral imaging. STUDY DESIGN/MATERIALS AND METHODS: OCT-images were generated by an experimental prototype (Medical Laser Center, Lubeck, Germany) using a superluminescence diode with a wavelength of 1310 nm. OCT-images were taken from two enucleated human eyes using 100-200 axial scans with 60 Hz line scan frequency and compared to subsequent histologic sections. RESULTS: Transscleral OCT allowed penetration of the sclera and the anterior chamber angle could be completely identified. Some change within the anterior eye segment could be demonstrated with high accuracy. Additionally, limited demonstration of the ciliary body region was achieved. Due to limited signal intensity no detailed imaging of the pars plana and pars plicata region was possible. However, more posterior measurements allowed transscleral visualization of a retinal detachment. CONCLUSIONS: OCT using lightsources with a wavelength longer than that used in conventional OCT provides a promising imaging technique at high resolution allowing transscleral imaging of the anterior eye segment.},
       keywords = {Anterior Chamber/cytology
    Anterior Eye Segment/cytology
    Ciliary Body/cytology
    Equipment Design
    Eye/*cytology
    Humans
    Tomography/instrumentation/*methods},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11891740},
       year = {2002},
       type = {Journal Article}
    }
    
  • Muller-Velten, R. and Hillmann, K. and Birngruber, R. and Noack, J. and Schmidt-Erfurth, U.: Topographic imaging and quantification of retinal vascular leakage in venous branch occlusion. Investigative Ophthalmology & Visual Science, no. 43, pp. U805-U805, 2002
    BibTeX Link
    @article{Müller-Velten2002,
       author = {Muller-Velten, R. and Hillmann, K. and Birngruber, R. and Noack, J. and Schmidt-Erfurth, U.},
       title = {Topographic imaging and quantification of retinal vascular leakage in venous branch occlusion},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {43},
       pages = {U805-U805},
       note = {Suppl. 2
    709CG
    2859
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000184606700021},
       year = {2002},
       type = {Journal Article}
    }
    
  • Framme, C. and Schuele, G. and Roider, J. and Birngruber, R. and Brinkmann, R.: Threshold determinations for selective RPE damage with repetitively pulsed microsecond laser systems in rabbits. Investigative Ophthalmology & Visual Science, no. 43, pp. U595-U595, 2002
    BibTeX Link
    @article{Framme2002,
       author = {Framme, C. and Schuele, G. and Roider, J. and Birngruber, R. and Brinkmann, R.},
       title = {Threshold determinations for selective RPE damage with repetitively pulsed microsecond laser systems in rabbits},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {43},
       pages = {U595-U595},
       note = {Suppl. 1
    709CF
    2530
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000184606602462},
       year = {2002},
       type = {Journal Article}
    }
    
  • Framme, C. and Schuele, G. and Roider, J. and Kracht, D. and Birngruber, R. and Brinkmann, R.: Threshold determinations for selective retinal pigment epithelium damage with repetitive pulsed microsecond laser systems in rabbits. Ophthalmic Surgery and Lasers, no. 33, pp. 400-409, 2002
    BibTeX
    @article{Framme2002,
       author = {Framme, C. and Schuele, G. and Roider, J. and Kracht, D. and Birngruber, R. and Brinkmann, R.},
       title = {Threshold determinations for selective retinal pigment epithelium damage with repetitive pulsed microsecond laser systems in rabbits},
       journal = {Ophthalmic Surgery and Lasers},
       volume = {33},
       number = {5},
       pages = {400-409},
       note = {596HY
    Times Cited:18
    Cited References Count:28},
       abstract = {BACKGROUND AND OBJECTIVE: In both clinical and animal studies, it has been shown that repetitive short laser pulses can cause selective retinal pigment epithelium damage (RPE) with sparing of photoreceptors. Our purpose was to determine the ophthalmoscopic and angiographic damage thresholds as a function of pulse durations by using different pulsed laser systems to optimize treatment modalities.
    MATERIALS AND METHODS: Chinchilla-breed rabbits were narcotized and placed in a special holding system. Laser lesions were applied using a commercial laser slit lamp, contact lens, and irradiation with a frequency-doubled Nd:YLF laser (wavelength: 527 nm; repetition rate: 500 Hz; number of pulses: 100; pulse duration: 5 mus, 1.7 mus, 200 ns) and an argon-ion laser (514 nm, 500 Hz, 100 pulses, 5 mus and 200 ins). In all eyes, spots with different energies were placed into the regio macularis with a diameter of 102 mum (tophat profile). After treatment, fundus photography and fluorescein angiography were performed and radiant exposure for ED50 damage determined. Speckle measurements at the fiber tips were performed to determine intensity peaks in the beam profile.
    RESULTS: Using the Nd:YLF laser system, the ophthalmoscopic ED50 threshold energies were 25.4 lJ (5 mus), 32 muJ (1.7 mus), and 30 muJ (200 ns). The angiographic ED50 thresholds were 13.4 muJ (5 mus), 9.2 muJ (1.7 mus), and 6.7 muJ (200 ns). With the argon laser, the angiographic threshold for 5 mus pulses was 5.5 muJ. The ophthalmoscopic threshold could not be determined because of a lack of power; however, it was > 12 muJ. For 200 ms, the ED50 radiant exposures were 20.4 mW ophthalmoscopically and 19.2 mW angiographically. Speckle factors were found to be 1.225 for the Nd:YLF and 3.180 for the argon laser. Thus, the maximal ED50-threshold radiant exposures for the Nd:YLF were calculated to be 362 mJ/cm(2) (5 mus), 478 mJ/cm(2) (1.7 mus), and 438 mJ/cm(2) (200 ns) ophthalmoscopically. Angiographically, the thresholds were 189 mJ/cm(2) (5 mus), 143 mJ/cm(2) (1.7 mus), and 97 mJ/cm(2) (200 ns). For the argon laser, the maximal ED50 radiant exposure threshold was 170 mJ/cm(2) angiographically.
    CONCLUSION: The gap between the angiographic and the ophthalmoscopic thresholds for the 200 ns regime (4.5 times above angiographic ED50) was wider than for the 1.7 mus regime (3.3 times above the angiographic ED50). This would suggest the appropriate treatment would be 200 ns pulses. However, histologies have yet to prove that nonvisible mechanical effects increase with shorter pulse durations and could reduce the "therapeutic window." When comparing the thresholds with 5 mus pulses from the argon and Nd:YLF laser, it demonstrates that intensity modulations in the beam profile must be considered.},
       keywords = {primate eye
    photocoagulation
    neovascularization
    nanosecond
    lesions
    model},
       ISSN = {0022-023X},
       url = {<Go to ISI>://WOS:000178160100008},
       year = {2002},
       type = {Journal Article}
    }
    
  • Framme, C. and Schuele, G. and Roider, J. and Kracht, D. and Birngruber, R. and Brinkmann, R.: Threshold determinations for selective retinal pigment epithelium damage with repetitive pulsed microsecond laser systems in rabbits. no. 33, pp. 400-9, Sep-Oct, 2002
    BibTeX
    @misc{Framme,
       author = {Framme, C. and Schuele, G. and Roider, J. and Kracht, D. and Birngruber, R. and Brinkmann, R.},
       title = {Threshold determinations for selective retinal pigment epithelium damage with repetitive pulsed microsecond laser systems in rabbits},
       volume = {33},
       number = {5},
       pages = {400-9},
       month = {Sep-Oct},
       note = {1082-3069 (Print)
    Comparative Study
    Journal Article},
       abstract = {BACKGROUND AND OBJECTIVE: In both clinical and animal studies, it has been shown that repetitive short laser pulses can cause selective retinal pigment epithelium damage (RPE) with sparing of photoreceptors. Our purpose was to determine the ophthalmoscopic and angiographic damage thresholds as a function of pulse durations by using different pulsed laser systems to optimize treatment modalities. MATERIALS AND METHODS: Chinchilla-breed rabbits were narcotized and placed in a special holding system. Laser lesions were applied using a commercial laser slit lamp, contact lens, and irradiation with a frequency-doubled Nd:YLF laser (wave-length: 527 nm; repetition rate: 500 Hz; number of pulses: 100; pulse duration: 5 micros, 1.7 micros, 200 ns) and an argon-ion laser (514 nm, 500 Hz, 100 pulses, 5 micros and 200 ms). In all eyes, spots with different energies were placed into the regio macularis with a diameter of 102 microm (tophat profile). After treatment, fundus photography and fluorescein angiography were performed and radiant exposure for ED50 damage determined. Speckle measurements at the fiber tips were performed to determine intensity peaks in the beam profile. RESULTS: Using the Nd:YLF laser system, the ophthalmoscopic ED50 threshold energies were 25.4 microJ (5 micros), 32 microJ (1.7 micros), and 30 microJ (200 ns). The angiographic ED50 thresholds were 13.4 microJ (5 micros), 9.2 microJ (1.7 micros), and 6.7 microJ (200 ns). With the argon laser, the angiographic threshold for 5 micros pulses was 5.5 microJ. The ophthalmoscopic threshold could not be determined because of a lack of power; however, it was > 12 microJ. For 200 ms, the ED50 radiant exposures were 20.4 mW ophthalmoscopically and 19.2 mW angiographically. Speckle factors were found to be 1.225 for the Nd:YLF and 3.180 for the argon laser. Thus, the maximal ED50 -threshold radiant exposures for the Nd:YLF were calculated to be 362 mJ/cM2 (5 micros), 478 mJ/cm2 (1.7 micros), and 438 mJ/cm2 (200 ns) ophthalmoscopically. Angiographically, the thresholds were 189 mJ/cm2 (5 micros), 143 mJ/cm2 (1.7 micros), and 97 mJ/cm2 (200 ns). For the argon laser, the maximal ED50 radiant exposure threshold was 170 mJ/cm2 angiographically. CONCLUSION: The gap between the angiographic and the ophthalmoscopic thresholds for the 200 ns regime (4.5 times above angiographic ED50) was wider than for the 1.7 micros regime (3.3 times above the angiographic ED50). This would suggest the appropriate treatment would be 200 ns pulses. However, histologies have yet to prove that nonvisible mechanical effects increase with shorter pulse durations and could reduce the "therapeutic window." When comparing the thresholds with 5 micros pulses from the argon and Nd:YLF laser, it demonstrates that intensity modulations in the beam profile must be considered.},
       keywords = {Animals
    Eye Injuries/diagnosis/*etiology
    Fluorescein Angiography
    Laser Coagulation/*adverse effects
    Ophthalmoscopy
    Photography
    Pigment Epithelium of Eye/*injuries
    Rabbits
    Retina/*surgery
    Threshold Limit Values
    Time Factors},
       year = {2002}
    }
    
  • Schmidt-Erfurth, U. M. and Ahlswede, W. and Michels, S. and Birngruber, R. and Laqua, H.: Three-dimensional analysis of photodynamic therapy (PDT)-induced vascular effects in choroidal neovascularization (CNV) and choroid: A two year follow-up. Investigative Ophthalmology & Visual Science, no. 43, pp. U1143-U1143, 2002
    BibTeX Link
    @article{Schmidt-Erfurth2002,
       author = {Schmidt-Erfurth, U. M. and Ahlswede, W. and Michels, S. and Birngruber, R. and Laqua, H.},
       title = {Three-dimensional analysis of photodynamic therapy (PDT)-induced vascular effects in choroidal neovascularization (CNV) and choroid: A two year follow-up},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {43},
       pages = {U1143-U1143},
       note = {Suppl. 2
    709CG
    3978
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000184606701132},
       year = {2002},
       type = {Journal Article}
    }
    
  • Brujan, EA. and Keen, G.S. and Vogel, A. and Blake, J.R.: The final stage of the collapse of a cavitation bubble close to a rigid boundary. Phys Fluids, no. 14, pp. 85-92, 2002
    BibTeX
    @article{Brujan2002,
       author = {Brujan, EA. and Keen, G.S. and Vogel, A. and Blake, J.R.},
       title = {The final stage of the collapse of a cavitation bubble close to a rigid boundary},
       journal = {Phys Fluids},
       volume = {14},
       pages = {85-92},
       year = {2002}
    }
    
    
  • Brinkmann, R. and Koop, N. and Oezdemir, M. and Alt, C. and Schuele, G. and Lin, C. P. and Birngruber, R.: Selective RPE damage by means of a rapidly scanned cw laser beam. Investigative Ophthalmology & Visual Science, no. 43, pp. U595-U595, 2002
    BibTeX Link
    @article{Brinkmann2002,
       author = {Brinkmann, R. and Koop, N. and Oezdemir, M. and Alt, C. and Schuele, G. and Lin, C. P. and Birngruber, R.},
       title = {Selective RPE damage by means of a rapidly scanned cw laser beam},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {43},
       pages = {U595-U595},
       note = {Suppl. 1
    709CF
    2535
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000184606602467},
       year = {2002},
       type = {Journal Article}
    }
    
  • Brinkmann, R and Koop, N and Özdemir, M and Alt, C and Schüle, G and Lin, C P and Birngruber, R: Selective damage of pigmented cells by means of a rapidly scanned cw laser beam. Proc SPIE, no. 4617, pp. 134-140, 2002
    BibTeX
    @article{Brinkmann2002,
       author = {Brinkmann, R  and Koop, N and Özdemir, M  and Alt, C and Schüle, G and Lin, C P and Birngruber, R},
       title = {Selective damage of pigmented cells by means of a rapidly scanned cw laser beam},
       journal = {Proc SPIE},
       volume = {4617},
       pages = {134-140},
       year = {2002},
       type = {Journal Article}
    }
    
  • Venugopalan, V. and Guerra, A. and Nahen, K. and Vogel, A.: Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation. Phys Rev Let, no. 88, pp. 078103 (1-4), 2002
    BibTeX
    @article{Venogupalan,
       author = {Venugopalan, V. and Guerra, A. and Nahen, K. and Vogel, A.},
       title = {Role of Laser-Induced Plasma Formation in Pulsed Cellular Microsurgery and Micromanipulation},
       journal = {Phys Rev Let},
       volume = {88},
       number = {7},
       pages = {078103 (1-4)},
       year = {2002}
    }
    
  • Huber, Robert and Moser, Jacques-E. and Grätzel, Michael and Wachtveitl, Josef: Real-Time Observation of Photoinduced Adiabatic Electron Transfer in Strongly Coupled Dye/Semiconductor Colloidal Systems with a 6 fs Time Constant. The Journal of Physical Chemistry B, no. 106, pp. 6494-6499, jun,, 2002
    BibTeX Link
    @Article{HU_2002_Huber_a,
      Title                    = {{Real-Time Observation of Photoinduced Adiabatic Electron Transfer in Strongly Coupled Dye/Semiconductor Colloidal Systems with a 6 fs Time Constant}},
      Author                   = {Huber, Robert and Moser, Jacques-E. and Gr\"{a}tzel, Michael and Wachtveitl, Josef},
      Journal                  = {The Journal of Physical Chemistry B},
      Year                     = {2002},
    
      Month                    = jun,
      Number                   = {25},
      Pages                    = {6494--6499},
      Volume                   = {106},
    
      Doi                      = {10.1021/jp0155819},
      ISSN                     = {1520-6106},
      Url                      = {http://pubs.acs.org/doi/abs/10.1021/jp0155819}
    }
  • Nahen, K. and Vogel, A.: Plume dynamics and shielding by the ablation plume during Er:YAG laser ablation. Journal of Biomedical Optics, no. 7, pp. 165-178, 2002
    BibTeX
    @article{Nahen,
       author = {Nahen, K. and Vogel, A.},
       title = {Plume dynamics and shielding by the ablation plume during Er:YAG laser ablation},
       journal = {Journal of Biomedical Optics},
       volume = {7},
       number = {2},
       pages = {165-178},
       year = {2002}
    }
    
  • Wachtveitl, Josef and Huber, Robert and Moser, Jacques E and Gratzel, Michael: Photoinduced electron transfer in dye/semiconductor systems on a sub-10-fs time scale - 2002 OSA Technical Digest Series. in The Thirteenth International Conference on Ultrafast Phenomena, pp. ThC5, Optical Society of America, 2002
    BibTeX
    @InProceedings{HU_2002_Wachtveitl_a,
      Title                    = {{Photoinduced electron transfer in dye/semiconductor systems on a sub-10-fs time scale - 2002 OSA Technical Digest Series}},
      Author                   = {Wachtveitl, Josef and Huber, Robert and Moser, Jacques E and Gratzel, Michael},
      Booktitle                = {The Thirteenth International Conference on Ultrafast Phenomena},
      Year                     = {2002},
      Pages                    = {ThC5},
      Publisher                = {Optical Society of America},
    
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?URI=UP-2002-ThC5}
    }
  • Hüttmann, G and Houserek, S. and Diddens, H. and Hendrich, C.: Photodynamische Therapie in der Orthopädie. pp. 344-352, 2002
    BibTeX
    @misc{Hüttmann,
       author = {Hüttmann, G and Houserek, S. and Diddens, H. and Hendrich, C.},
       title = {Photodynamische Therapie in der Orthopädie},
       pages = {344-352},
       year = {2002}
    }
    
  • Brix, A and Vogel, A and Winkler, J and Dröge, G and Birngruber, R and Laqua, H and Hoerauf, H: Photoablation innerer Netzhautschichten mit dem Erbium: YAG-Laser in vitro. Focus Mul / Medizinische Universität <Lübeck>, no. 19, pp. 35, 2002
    BibTeX Link
    @article{Brix2002,
       author = {Brix, A and Vogel, A and Winkler, J and Dröge, G and Birngruber, R and Laqua, H and Hoerauf, H},
       title = {Photoablation innerer Netzhautschichten mit dem Erbium: YAG-Laser in vitro},
       journal = {Focus Mul / Medizinische Universität <Lübeck>},
       volume = {19},
       number = {1},
       pages = {35},
       ISSN = {0940-9998},
       url = {http://www.zbmed.de/ccmedimages/2002/24278.pdf},
       year = {2002},
       type = {Journal Article}
    }
    
  • Huber, Robert and Moser, Jacques E and Grätzel, Michael and Wachtveitl, Josef: Observation of photoinduced electron transfer in dye/semiconductor colloidal systems with different coupling strengths. in Chemical Physics, no. 285, pp. 39-45, dec,, 2002
    BibTeX Link
    @InProceedings{HU_2002_Huber_b,
      Title                    = {{Observation of photoinduced electron transfer in dye/semiconductor colloidal systems with different coupling strengths}},
      Author                   = {Huber, Robert and Moser, Jacques E and Gr\"{a}tzel, Michael and Wachtveitl, Josef},
      Booktitle                = {Chemical Physics},
      Year                     = {2002},
      Month                    = dec,
      Number                   = {1},
      Pages                    = {39--45},
      Volume                   = {285},
    
      Doi                      = {10.1016/S0301-0104(02)00687-0},
      ISSN                     = {03010104},
      Url                      = {http://linkinghub.elsevier.com/retrieve/pii/S0301010402006870}
    }
  • Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Pham, D. T. and Laqua, H. and Birngruber, R.: Noncontact corneal pachymetry with slit lamp-adapted optical coherence tomography. American Journal of Ophthalmology, no. 133, pp. 444-450, 2002
    BibTeX Link
    @article{Wirbelauer2002,
       author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Pham, D. T. and Laqua, H. and Birngruber, R.},
       title = {Noncontact corneal pachymetry with slit lamp-adapted optical coherence tomography},
       journal = {American Journal of Ophthalmology},
       volume = {133},
       number = {4},
       pages = {444-450},
       note = {538DE
    Times Cited:73
    Cited References Count:35},
       abstract = {PURPOSE: The purpose of this study was to determine the accuracy, the reproducibility, and the limits of agreement of noncontact central corneal thickness measurement with slit lamp adapted optical coherence tomography (OCT). DESIGN: Nonrandomized comparative clinical trial.
    METHODS: In a prospective comparative observational study, a total of 108 consecutive patients ( 108 eyes) with normal corneas (92 eyes) and different corneal alters ations (16 eyes) participated. Six sequential measure. ments of the central corneal thickness with slit lamp-adapted OCT and with ultrasound (US) pachymetry at 1640 ms(-1) were performed. The main outcome measures were accuracy, reproducibility assessed with precision and coefficient of variation (CV), and limits of agreement of central corneal thickness measurement.
    RESULTS: The mean central corneal thickness values were 541 +/- 43 mum (OCT) and 549 +/- 44 mum (US) with a mean precision of +/- 5.8 mum (CV 1.08%) and of +/- 4.0 mum (CV 0.73%), respectively. The method comparison revealed equivalence (+/- 2SD) in the 5% range with a mean difference between both methods of 7.9 mum (1-45%). The relative error was 8.7 mum (1.6%), which corresponded to limits of agreement (+/- 2SD) ranging from -9.5 mum to 25.3 mum.
    CONCLUSIONS: Central corneal pachymetry with slit lamp,adapted OCT revealed, for clinical purposes, an excellent accuracy and reproducibility with a high degree of agreement compared with US pachymetry. Thus, the presented OCT system seems to be a promising diagnostic modality to objectively measure corneal thickness in a convenient noncontact mode. (C) 2002 by Elsevier Science Inc. All rights reserved.},
       keywords = {in-situ keratomileusis
    anterior segment
    human-eye
    thickness
    interferometry
    regression
    precision},
       ISSN = {0002-9394},
       DOI = {Pii S0002-9394(01)01425-8
    Doi 10.1016/S0002-9394(01)01425-8},
       url = {<Go to ISI>://WOS:000174798200002},
       year = {2002},
       type = {Journal Article}
    }
    
  • Vogel, A. and Schmidt, P. and Flucke, B.: Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses. SPIE Proc. Laser Tissue Interaction XIII, no. 4617A, 2002
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Schmidt, P. and Flucke, B.},
       title = {Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses},
       journal = {SPIE Proc. Laser Tissue Interaction XIII},
       volume = {4617A},
       year = {2002}
    }
    
  • Vogel, A. and Schmidt, P. and Flucke, B.: Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses. SPIE Proc. Laser Tissue Interaction XIII, no. 4617A, 2002
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Schmidt, P. and Flucke, B.},
       title = {Minimization of thermomechanical side effects and increase of ablation efficiency in IR ablation by use of multiply Q-switched laser pulses},
       journal = {SPIE Proc. Laser Tissue Interaction XIII},
       volume = {4617A},
       year = {2002}
    }
    
  • Vogel, A. and Hüttmann, G. and Paltauf, G.: Low-density plasmas below the optical breakdown threshold: potential hazard for multiphoton microscopy, and a tool for the manipulation of intracellular events. Proc SPIE Multiphoton Microscopy in the Biomedical Sciences II, no. 4620, pp. 202-216, 2002
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Hüttmann, G. and Paltauf, G.},
       title = {Low-density plasmas below the optical breakdown threshold: potential hazard for multiphoton microscopy, and a tool for the manipulation of intracellular events},
       journal = {Proc SPIE "Multiphoton Microscopy in the Biomedical Sciences II"},
       volume = {4620},
       pages = {202-216},
       year = {2002}
    }
    
  • Y, Miura and T, Yokoyma and H, Tabuchi and M, Yamaguchi and N, Hosoda and Y, Miyata: Long-term outcome of juvenile-onset myasthenia ocularis treated by systemic corticosteroid. Japanese review of clinical ophthalmology.. Japanese Review of Clinical Ophthalmology, no. 96, pp. 1133-1135, 2002
    BibTeX
    @article{Miura2002,
       author = {Y, Miura and T, Yokoyma and H, Tabuchi and M, Yamaguchi and N, Hosoda and Y, Miyata},
       title = {Long-term outcome of juvenile-onset myasthenia ocularis treated by systemic corticosteroid. Japanese review of clinical ophthalmology. },
       journal = {Japanese Review of Clinical Ophthalmology},
       volume = {96},
       number = {11},
       pages = {1133-1135},
       year = {2002}
    }
    
  • Vogel, Alfred . and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.: Intraocular Nd: YAG Laser Surgery: Light-Tissue Interaction, Damage Range, and Reduction of Collateral Effects. IEEE J Quant Electr, no. 26, pp. 2241-2260, 2002
    BibTeX
    @article{Vogel2002,
       author = {Vogel, Alfred . and Schweiger, P. and Frieser, A. and Asiyo, M. and Birngruber, R.},
       title = {Intraocular Nd: YAG Laser Surgery: Light-Tissue Interaction, Damage Range, and Reduction of Collateral Effects},
       journal = {IEEE J Quant Electr},
       volume = {26},
       pages = {2241-2260},
       year = {2002},
       type = {Journal Article}
    }
    
  • Hüttmann, G. and Radt, B. and Serbin, J. and Lange, B.I. and Birngruber, R.: High Precision Cell Surgery with Nanoparticles?. Med Laser Appl, no. 17, pp. 9-14, 2002
    BibTeX
    @article{Hüttmann2002,
       author = {Hüttmann, G. and Radt, B. and Serbin, J. and Lange, B.I. and Birngruber, R.},
       title = {High Precision Cell Surgery with Nanoparticles?},
       journal = {Med Laser Appl},
       volume = {17},
       pages = {9-14},
       year = {2002},
       type = {Journal Article}
    }
    
  • Hüttmann, G. and Radt, B. and Serbin, J. and Lange, B.I. and Birngruber, R.: High Precision Cell Surgery with Nanoparticles?. Med Laser Appl, no. 17, pp. 9-14, 2002
    BibTeX
    @article{Hüttmann,
       author = {Hüttmann, G. and Radt, B. and Serbin, J. and Lange, B.I. and Birngruber, R.},
       title = {High Precision Cell Surgery with Nanoparticles?},
       journal = {Med Laser Appl},
       volume = {17},
       pages = {9-14},
       year = {2002}
    }
    
  • Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.: Femtosecond-laser-produced low-density plasmas in transparent biological media: A tool for the creation of chemical, thermal and thermomechanical effets below the optical brekdown threshold. Proc. SPIE Commercial and Biological Applications of Ultrafast Lasers IV, no. 4633, pp. 23-37, 2002
    BibTeX
    @article{Vogel, 
       author = {Vogel, A. and Noack, J. and Hüttmann, G. and Paltauf, G.},
       title = {Femtosecond-laser-produced low-density plasmas in transparent biological media: A tool for the creation of chemical, thermal and thermomechanical effets below the optical brekdown threshold},
       journal = {Proc. SPIE "Commercial and Biological Applications of Ultrafast Lasers IV"},
       volume = {4633},
       pages = {23-37},
       year = {2002}
    }
    
  • Huber, Robert: Elektronentransfer an Farbstoff-Halbleiter-Grenzflächen. Ludwig-Maximilians-Universität München, 2002
    BibTeX Link
    @PhdThesis{HU_2002_Huber_c,
      Title                    = {{Elektronentransfer an Farbstoff-Halbleiter-Grenzfl\"{a}chen}},
      Author                   = {Huber, Robert},
      School                   = {Ludwig-Maximilians-Universit\"{a}t M\"{u}nchen},
      Year                     = {2002},
    
      Publisher                = {Ludwig-Maximilians-Universit\"{a}t M\"{u}nchen},
      Url                      = {http://edoc.ub.uni-muenchen.de/93/1/Huber_Robert.pdf}
    }
  • Framme, C and Brinkmann, R and Birngruber, R and Roider, J: Autofluorescence imaging after selective RPE treatment in macular diseases and clinical outcome: a pilot study. Br J Ophthalmol, no. 86, pp. 1099-1106, 2002
    BibTeX
    @article{Framme2002,
       author = {Framme, C and Brinkmann, R and Birngruber, R and Roider, J},
       title = {Autofluorescence imaging after selective RPE treatment in macular diseases and clinical outcome: a pilot study},
       journal = {Br J Ophthalmol},
       volume = {86},
       pages = {1099-1106},
       year = {2002},
       type = {Journal Article}
    }
    
  • Framme, C and Brinkmann, R and Birngruber, R and Roider, J: Autofluorescence imaging after selective RPE treatment in macular diseases and clinical outcome: a pilot study. Br J Ophthalmol, no. 86, pp. 1099-1106, 2002
    BibTeX
    @article{Framme,
       author = {Framme, C and Brinkmann, R and Birngruber, R and Roider, J},
       title = {Autofluorescence imaging after selective RPE treatment in macular diseases and clinical outcome: a pilot study},
       journal = {Br J Ophthalmol},
       volume = {86},
       pages = {1099-1106},
       year = {2002}
    }
    
    
  • Framme, C. and Brinkmann, R. and Birngruber, R. and Roider, J.: Autofluorescence imaging after selective RPE laser treatment in macular diseases and clinical outcome: a pilot study. British Journal of Ophthalmology, no. 86, pp. 1099-1106, 2002
    BibTeX Link
    @article{Framme2002,
       author = {Framme, C. and Brinkmann, R. and Birngruber, R. and Roider, J.},
       title = {Autofluorescence imaging after selective RPE laser treatment in macular diseases and clinical outcome: a pilot study},
       journal = {British Journal of Ophthalmology},
       volume = {86},
       number = {10},
       pages = {1099-1106},
       note = {595YE
    Times Cited:47
    Cited References Count:35},
       abstract = {Aim: Selective retinal pigment epithelium (RPE) laser treatment is a new technique which selectively damages the RPE while sparing the neural retina. One difficulty is the inability to visualise the laser lesions, The aim of the study was to investigate whether fundus autofluorescence (AF) is changed because of the RPE damage, and thus might be used for treatment control. Additionally, the clinical course of patients with various macular diseases was evaluated.
    Methods: 26 patients with macular diseases (diabetic maculopathy (DMP), soft drusen maculopathy (AMD), and central serous retinopathy (CSR)) were treated and followed up for at least 6 months. Treatment was performed with a train of repetitive short laser pulses (800 ns) of a frequency doubled Nd:YAG laser (parameters: 532 nm, 50 and 500 pulses at 100 and 500 Hz, retinal spot diameter 200 pm, pulse energies 75-175 muJ). AF was excited by 488 nm and detected by a barrier filter at 500 nm (HRA, Heidelberg Engineering, Germany). Patients were examined by ophthalmoscopy, fluorescein angiography, and autofluorescence measurements at various times after treatment (10 minutes, 1 hour, 1 and 6 weeks, 3, 6, and 12 months).
    Results: Fluorescein angiography showed leakage from the irradiated areas for about I week after treatment. None of the laser lesions was ophthalmoscopically visible during treatment. Identification of the lesions was possible by AF imaging showing an intensity decay in the irradiated area in 22 out of 26 patients, predominantly in patients with CSR and AMD. Lesions could be identified 10 minutes after treatment as hypoautofluorescent spots, which were more pronounced I hour later. During follow up the laser spots became hyperautofluorescent. In patients with DMP some AF images were less helpful because of diffuse oedema and larger retinal thickness. In these cases ICG angiography was able to confirm therapeutic success very well. Most of the patients have had benefit from the treatment, with best results obtained for CSR patients.
    Conclusion: Imaging of non-visible selective RPE laser effects can be achieved by AF measurements predominantly in patients without retinal oedema. Therefore, AF may replace invasive fluorescein angiography in many cases to verify therapeutic laser success, Selective laser treatment has the potential to improve the prognosis of macular diseases without the risk of laser scotomas.},
       keywords = {retinal-pigment epithelium
    primate retina
    fundus autofluorescence
    scanning ophthalmoscope
    photocoagulation
    lipofuscin
    krypton
    fluorescence
    melanin
    lesions},
       ISSN = {0007-1161},
       DOI = {DOI 10.1136/bjo.86.10.1099},
       url = {<Go to ISI>://WOS:000178135200010},
       year = {2002},
       type = {Journal Article}
    }
    

2001

  • Arnold, J. and Kilmartin, D. and Olson, J. and Neville, S. and Robinson, K. and Laird, A. and Richmond, C. and Farrow, A. and McKay, S. and McKechnie, R. and Evans, G. and Aaberg, T. M. and Brower, J. and Waldron, R. and Loupe, D. and Gillman, J. and Myles, B. and Saperstein, D. A. and Schachat, A. P. and Bressler, N. M. and Bressler, S. B. and Nesbitt, P. and Porter, T. and Hawse, P. and Harnett, M. and Eager, A. and Belt, J. and Cain, D. and Emmert, D. and George, T. and Herring, M. and McDonald, J. and Mones, J. and Corcostegui, B. and Gilbert, M. and Duran, N. and Sisquella, M. and Nolla, A. and Margalef, A. and Miller, J. W. and Gragoudas, E. S. and Lane, A. M. and Emmanuel, N. and Holbrook, A. and Evans, C. and Lord, U. S. and Walsh, D. K. and Callahan, C. D. and DuBois, J. L. and Moy, J. and Kenney, A. G. and Milde, I. and Platz, E. S. and Lewis, H. and Kaiser, P. K. and Holody, L. J. and Lesak, E. and Lichterman, S. and Siegel, H. and Fattori, A. and Ambrose, G. and Fecko, T. and Ross, D. and Burke, S. and Conway, J. and Singerman, L. and Zegarra, H. and Novak, M. and Bartel, M. and Tilocco-DuBois, K. and Ilc, M. and Schura, S. and Joyce, S. and Tanner, V. and Rowe, P. and Smith-Brewer, S. and Greanoff, G. and Daley, G. and DuBois, J. and Lehnhardt, D. and Kukula, D. and Fish, G. E. and Jost, B. F. and Anand, R. and Callanan, D. and Arceneaux, S. and Arnwine, J. and Ellenich, P. and King, J. and Aguado, H. and Rollins, R. and Anderson, T. and Nork, C. and Duignan, K. and Boleman, B. and Jurklies, B. and Pauleikhoff, D. and Hintzmann, A. and Fischer, M. and Sowa, C. and Birngruber, R. and others: Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2. American Journal of Ophthalmology, no. 131, pp. 541-560, 2001
    BibTeX Link
    @article{Birngruber2001,
       author = {Arnold, J. and Kilmartin, D. and Olson, J. and Neville, S. and Robinson, K. and Laird, A. and Richmond, C. and Farrow, A. and McKay, S. and McKechnie, R. and Evans, G. and Aaberg, T. M. and Brower, J. and Waldron, R. and Loupe, D. and Gillman, J. and Myles, B. and Saperstein, D. A. and Schachat, A. P. and Bressler, N. M. and Bressler, S. B. and Nesbitt, P. and Porter, T. and Hawse, P. and Harnett, M. and Eager, A. and Belt, J. and Cain, D. and Emmert, D. and George, T. and Herring, M. and McDonald, J. and Mones, J. and Corcostegui, B. and Gilbert, M. and Duran, N. and Sisquella, M. and Nolla, A. and Margalef, A. and Miller, J. W. and Gragoudas, E. S. and Lane, A. M. and Emmanuel, N. and Holbrook, A. and Evans, C. and Lord, U. S. and Walsh, D. K. and Callahan, C. D. and DuBois, J. L. and Moy, J. and Kenney, A. G. and Milde, I. and Platz, E. S. and Lewis, H. and Kaiser, P. K. and Holody, L. J. and Lesak, E. and Lichterman, S. and Siegel, H. and Fattori, A. and Ambrose, G. and Fecko, T. and Ross, D. and Burke, S. and Conway, J. and Singerman, L. and Zegarra, H. and Novak, M. and Bartel, M. and Tilocco-DuBois, K. and Ilc, M. and Schura, S. and Joyce, S. and Tanner, V. and Rowe, P. and Smith-Brewer, S. and Greanoff, G. and Daley, G. and DuBois, J. and Lehnhardt, D. and Kukula, D. and Fish, G. E. and Jost, B. F. and Anand, R. and Callanan, D. and Arceneaux, S. and Arnwine, J. and Ellenich, P. and King, J. and Aguado, H. and Rollins, R. and Anderson, T. and Nork, C. and Duignan, K. and Boleman, B. and Jurklies, B. and Pauleikhoff, D. and Hintzmann, A. and Fischer, M. and Sowa, C. and Birngruber, R. and others },
       title = {Verteporfin therapy of subfoveal choroidal neovascularization in age-related macular degeneration: Two-year results of a randomized clinical trial including lesions with occult with no classic choroidal neovascularization-verteporfin in photodynamic therapy report 2},
       journal = {American Journal of Ophthalmology},
       volume = {131},
       number = {5},
       pages = {541-560},
       note = {431AN
    Times Cited:579
    Cited References Count:9},
       abstract = {PURPOSE: To determine if photodynamic therapy with verteporfin (Visudyne; Novartis AG, Bulach, Switzerland), termed verteporfin therapy, can safely reduce the risk of vision loss compared with a placebo (with sham treatment) in patients with subfoveal choroidal neovascularization caused by age-related macular degeneration who were identified with a lesion composed of occult with no classic choroidal neovascularization, or with presumed early onset classic choroidal neovascularization with good visual acuity letter score,
    METHODS: This was a double-masked, placebo controlled (sham treatment), randomized, multicenter clinical trial involving 28 ophthalmology practices in Europe and North America. The study population was patients with age related macular degeneration, with subfoveal choroidal neovascularization lesions measuring no greater than 5400 mum in greatest linear dimension with either 1) occult with no classic choroidal neovascularization, best-corrected visual acuity score of at least 50 (Snellen equivalent approximately 20/100), and evidence of hemorrhage or recent disease progression; or 2) evidence of classic choroidal neovascularization with a best-corrected visual acuity score of at least 70 (better than a Snellen equivalent of approximately 20/40); assigned randomly (2:1) to verteporfin therapy or placebo therapy. Verteporfin (6 mg per square meter of body surface area) or placebo (5% dextrose in water) was administered by means of intravenous infusion of 30 mi over 10 minutes. Fifteen minutes after the start of the infusion, a laser light at 689 nm delivered 50 J/cm(2) by application of an intensity of 600 mW/cm(2) over 83 seconds using a spot size with a diameter 1000 mum larger than the greatest linear dimension of the choroidal neovascularization lesion on the retina. At follow-up examinations every 3 months, retreatment with the same regimen was applied if angiography showed fluorescein leakage. The main outcome measure was at least moderate vision loss, that is, a loss of at least 15 letters (approximately 3 lines), adhering to an intent-to treat analysis with the last observation carried forward to impute for missing data.
    RESULTS: Two hundred ten (93%) and 193 (86%) of the 225 patients in the verteporfin group compared with 104 (91%) and 99 (87%) of the 114 patients in the placebo group completed the month 12 and 24 examinations, respectively. On average, verteporfin-treated patients received five treatments over the 24 months of follow-up. The primary outcome was similar for the verteporfin-treated and the placebo-treated eyes through the month 12 examination, although a number of secondary visual and angiographic outcomes significantly favored the verteporfin-treated group. Between the month 12 and 24 examinations, the treatment benefit grew so that by the month 24 examination, the vertepor-fin-treated eyes were less likely to have moderate or severe vision loss. Of the 225 verteporfin-treated patients, 121 (54%) compared with 76 (67%) of 114 placebo-treated patients lost at least 15 letters (P =.023). Likewise, 61 of the verteporfin-treated patients (30%) compared with 54 of the placebo-treated patients (47%) lost at least 30 letters (P = .001). Statistically significant results favoring verteporfin therapy at the month 24 examination were consistent between the total population and the subgroup of patients with a baseline lesion composition identified as occult choroidal neovascularization with no classic choroidal neovascularization, This subgroup included 166 of the 225 verteporfin-treated patients (74%) and 92 of the 114 placebo-treated patients (81%). In these patients, 91 of the verteporfin-treated group (55%) compared with 63 of the placebo-treated group (68%) lost at least 15 letters (P =.032), whereas 48 of the verteporfin-treated group (29%) and 43 of the placebo-treated group (47%) lost at least 30 letters (P =.004). Other secondary outcomes, including visual acuity letter score worse than 34 (approximate Snellen equivalent of 20/200 or worse), mean change in visual acuity letter score, development of classic choroidal neovascularization, progression of classic choroidal neovascularization and size of lesion, favored the verteporfin-treated group at both the month 12 and month 24 examination for both the entire study group and the subgroup of cases with occult with no classic choroidal neovascularization at baseline. Subgroup analyses of lesions composed of occult with no classic choroidal neovascularization at baseline suggested that the treatment benefit was greater for patients with either smaller lesions (4 disc areas or less) or lower levels of visual acuity (letter score less than 65, an approximate Snellen equivalent of 20/50(-1) or worse) at baseline. Prospectively planned multivariable analyses confirmed that these two baseline variables affected the magnitude of treatment benefit. Of the 123 verteporfin-treated patients and 64 placebo-heated patients with either visual acuity score Less than 65 or lesion size 4 disc areas or less at baseline, 60 (49%) and 48 (75%) lost at least 15 letters (P < .001), respectively, and 26 (21%) and 31 (48%) lost at least 30 letters (P <.001), respectively, at the month 24 examination. Conversely, treatment may not be beneficial for patients with both larger lesions and good visual acuity (both greater than 4 disc areas and letter score 65 or greater, an approximate Snellen equivalent of 20/50 or better). With respect to safety for the entire study group, 10 of 225 verteportin-treated patients (4.
    4%) and none of the placebo-treated patients had a severe decrease of vision (at least 20 letters compared with the visual acuity just before the treatment) within 7 days after treatment, judged to be the result of the development of subretinal pigment epithelial blood, marked subretinal fluid associated with choroidal hypofluorescence, or no obvious cause. Five of these 10 patients had recovery of vision to less than a 20-letter loss compared with the pretreatment vision score at 3 months after this event. Photosensitivity reactions occurred in only one patient in each group.
    CONCLUSIONS: In this trial of patients with agerelated macular degeneration and subfoveal choroidal neovascularisation lesions composed of occult with no classic choroidal neovascularization, verteporfin therapy significantly reduced the risk of moderate and severe visual acuity loss. Subgroup analyses suggest that a greater benefit was achieved in patients presenting with either smaller lesions (4 disc areas or less) or lower levels of visual acuity (letter score less than 65, an approximate Snellen equivalent of 20/50(-1) or less). The Verteporfin In Photodynamic Therapy Study Group recommends that this therapy should be considered for the treatment of patients with age-related macular degeneration with subfoveal lesions composed of occult with no classic choroidal neovascularization who are presumed to have recent disease progression. Patients to be treated should be aware of a small (4%) risk of acute, severe vision decrease.<(c)> 2001 by Elsevier Science Inc. All rights reserved.).},
       ISSN = {0002-9394},
       url = {<Go to ISI>://WOS:000168609900001},
       year = {2001},
       type = {Journal Article}
    }
    
  • Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Bastian, G. O. and Engelhardt, R. and Birngruber, R. and Laqua, H.: Untersuchungen der Hornhaut mittels optischer Kohärenztomographie.. Ophthalmologe, no. 98, pp. 151-156, 2001
    BibTeX
    @article{Wirbelauer2001,
       author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Bastian, G. O. and Engelhardt, R. and Birngruber, R. and Laqua, H.},
       title = {Untersuchungen der Hornhaut mittels optischer Kohärenztomographie.},
       journal = {Ophthalmologe},
       volume = {98},
       pages = {151-156},
       year = {2001},
       type = {Journal Article}
    
  • Schmidt-Erfurth, U. and Teschner, S. and Noack, J. and Birngruber, R.: Three-dimensional topographic angiography in chorioretinal vascular disease. Investigative Ophthalmology & Visual Science, no. 42, pp. 2386-2394, 2001
    BibTeX Link
    @article{Schmidt-Erfurth2001,
       author = {Schmidt-Erfurth, U. and Teschner, S. and Noack, J. and Birngruber, R.},
       title = {Three-dimensional topographic angiography in chorioretinal vascular disease},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {42},
       number = {10},
       pages = {2386-2394},
       note = {469FL
    Times Cited:11
    Cited References Count:31},
       abstract = {PURPOSE. To evaluate a new angiographic technique that offers three-dimensional imaging of chorioretinal vascular diseases.
    METHODS. Fluorescein (FA) and indocyanine green angiography (ICGA) were performed using. a confocal scanning laser ophthalmoscope. Tomographic series with 32 images per set were taken over a depth of 4 min at an image frequency of 20 Hz. An axial analysis was performed for each x/y position to determine the fluorescence distribution along, the z-axis. The location of the onset of fluorescence at a defined threshold intensity was identified and a depth profile was generated. The overall results of fluorescence topography were displayed in a gray scale-coded image and three-dimensional relief.
    RESULTS. Topographic angiography delineated the choriocapillary surface covering.. the posterior pole with exposed larger retinal vessels. Superficial masking of fluorescence by hemorrhage or absorbing fluid did not preclude detection of underlying diseases. Choroidal neovascularization (CNV) appeared as a vascular formation with distinct configuration and prominence. Chorioretinal infiltrates exhibited perfusion defects with dye pooling. Retinal pigment epithelium detachments (PEDs) demonstrated dynamic filling mechanisms. Intraretinal extravasation in retinal vascular disease was, detected within a well-demarcated area with prominent retinal thickening.
    CONCLUSIONS. Confocal topographic angiography allows high-resolution three-dimensional imaging, of chorioretinal vascular and exudative diseases. Structural vascular changes (e.g., proliferation) are detected in respect to location and size. Dynamic processes (e.g., perfusion defects, extravasation, and barrier dysfunction) are clearly identified and may be quantified. Topographic angiography is a promising technique in the diagnosis, therapeutic evaluation, and pathophysiological evaluation of macular disease.},
       keywords = {indocyanine green angiography
    scanning laser ophthalmoscope
    occult choroidal neovascularization
    optical coherence tomography
    cystoid macular edema
    fluorescein angiography
    fundus camera
    in-vivo
    videoangiography
    degeneration},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000170803900032},
       year = {2001},
       type = {Journal Article}
    }
    
  • Schmidt-Erfurth, U. M. and Niemeyer, M. and Michels, S. and Birngruber, R. and Laqua, H.: Three-dimensional imaging of dynamic and structural vascular changes induced by photodynamic therapy.. Investigative Ophthalmology & Visual Science, no. 42, pp. S512-S512, 2001
    BibTeX Link
    @article{Schmidt-erfurth2001,
       author = {Schmidt-Erfurth, U. M. and Niemeyer, M. and Michels, S. and Birngruber, R. and Laqua, H.},
       title = {Three-dimensional imaging of dynamic and structural vascular changes induced by photodynamic therapy.},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {42},
       number = {4},
       pages = {S512-S512},
       note = {Suppl. S
    427EP
    2760
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000168392102729},
       year = {2001},
       type = {Journal Article}
    }
    
  • Schneider-Brachert, W. and Birngruber, R. and Linde, H. J. and Miehlke, S. and Bayerdorffer, E. and Lehn, N.: Susceptibility of clinical ciprofloxacin-resistant isolates of Helicobacter pylori to new fluoroquinolones. Gut, no. 49, pp. A96-A96, 2001
    BibTeX Link
    @article{Schneider-Brachert2001,
       author = {Schneider-Brachert, W. and Birngruber, R. and Linde, H. J. and Miehlke, S. and Bayerdorffer, E. and Lehn, N.},
       title = {Susceptibility of clinical ciprofloxacin-resistant isolates of Helicobacter pylori to new fluoroquinolones},
       journal = {Gut},
       volume = {49},
       pages = {A96-A96},
       note = {Suppl. 2
    476NB
    1553
    Times Cited:0
    Cited References Count:0},
       ISSN = {0017-5749},
       url = {<Go to ISI>://WOS:000171232500340},
       year = {2001},
       type = {Journal Article}
    }
    
  • Obana, A and Goto, Y and Wada, S and Miura, Y and Miki, T and Cho, A: Surgical outcomes in removal of epimacular membranes. Journal of ophthalmic surgery, no. 14, pp. 253-256, 2001
    BibTeX
    @article{Miura2001,
       author = {Obana, A and Goto, Y and Wada, S and Miura, Y and Miki, T and Cho, A},
       title = {Surgical outcomes in removal of epimacular membranes},
       journal = { Journal of ophthalmic surgery},
       volume = {14},
       number = {2},
       pages = {253-256},
       abstract = {Removal of epiretinal membrane of the macula was performed in 49 eyes of 48 consecutive patients, and visual prognosis was analyzed retrospectively. Best-corrected visual acuity improved in 32 eyes (65%), and was unchanged in 17 eyes (35%). Metamorphopsia improved in 27 eyes (60%), and was unchanged in 18 eyes (40%). Eyes having proliferative tissue on the retinal surface after removal of epiretinal membrane showed significantly poorer improvement of metamorphopsia than those having a smooth retinal surface. However, duration of visual disturbance before surgery and preoperative visual acuity were not associated with the outcome of the metamorphopsia. Intentional peeling of the internal-limiting membrane was performed after removal of the epiretinal membrane in 17 of 40 eyes with idiopathic epiretinal membrane, and the effect of this procedure on improvement of metamorphopsia was evaluated. Internal-limiting membrane peeling did not influence the rate of improvement of metamorphopsia, however, its efficacy and safety remain to be determined in larger case series. (author abst.)},
       year = {2001}
    }
    
  • Nahen, K. and Vogel, Alfred: Shielding by the ablation plume during Er:YAG laser ablation. SPIE Proc., no. 4257, pp. 303-311, 2001
    BibTeX
    @article{Nahen2001,
       author = {Nahen, K. and Vogel, Alfred},
       title = {Shielding by the ablation plume during Er:YAG laser ablation},
       journal = {SPIE Proc.},
       volume = {4257},
       pages = {303-311},
       year = {2001},
       type = {Journal Article}
    }
    
  • Roider, J. and Brinkmann, R. and Framme, C. and Schule, G. and Joachimeyer, E. and Wirbelauer, C. and Kracht, D. and Laqua, H. and Birngruber, R.: Selective RPE laser treatment in macular diseases: Clinical results.. Investigative Ophthalmology & Visual Science, no. 42, pp. S695-S695, 2001
    BibTeX Link
    @article{Roider2001,
       author = {Roider, J. and Brinkmann, R. and Framme, C. and Schule, G. and Joachimeyer, E. and Wirbelauer, C. and Kracht, D. and Laqua, H. and Birngruber, R.},
       title = {Selective RPE laser treatment in macular diseases: Clinical results.},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {42},
       number = {4},
       pages = {S695-S695},
       note = {Suppl. S
    427EP
    3741
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000168392103704},
       year = {2001},
       type = {Journal Article}
    }
    
  • Arnold, J. and Kilmartin, D. and Olson, J. and Neville, S. and Robinson, K. and Birngruber, R. and Laird, A. and Richmond, C. and Farrow, A. and McKay, S. and Saperstein, D. A. and Aaberg, T. M. and Johnson, J. B. and Waldron, R. and Loupe, D. and Gillman, J. and Myles, B. and Schachat, A. P. and Bressler, N. M. and Bressler, S. B. and Nesbitt, P. and Porter, T. and Hawse, P. and Hartnett, M. and Eager, A. and Belt, J. and Cain, D. and Emmert, D. and George, T. and Herring, M. and McDonald, J. and Mones, J. and Corcostegui, B. and Gilbert, M. and Duran, N. and Sisquella, M. and Nolla, A. and Margalef, A. and Miller, J. W. and Gragoudas, E. S. and Lane, A. M. and Emmanuel, N. and Holbrook, A. and Evans, C. and Lord, U. S. and Walsh, D. K. and Callahan, C. D. and DuBois, J. L. and Lewis, H. and Kaiser, P. K. and Holody, L. J. and Lesak, E. and Lichterman, S. and Siegel, H. and Fattori, A. and Ambrose, G. and Fecko, T. and Ross, D. and Burke, S. and Singerman, L. and Zegarra, H. and Novak, M. and Bartel, M. and Tilocco-DuBois, K. and Iic, M. and Schura, S. and Mayes, S. J. and Tanner, V. and Rowe, P. and Smith-Brewer, S. and Kukula, D. and Greanoff, G. and Daley, G. and DuBois, J. and Lehnhardt, D. and Fish, G. E. and Jost, B. F. and Anand, R. and Callanan, D. and Arceneaux, S. and Arnwine, J. and Ellenich, P. and King, J. and Aguado, H. and Rollins, R. and Jurklies, B. and Pauleikhoff, D. and Hintzmann, A. and Fischer, M. and Sowa, C. and Behne, E. and Pournaras, C. J. and Donati, G. and Kapetanios, A. D. and Cavaliere, K. and Guney-Wagner, S. and Gerber, N. and Sickenberg, M. and Sickenberg, V. and Gans, A. and Hosner, B. and others: Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin - 1-year results of a randomized clinical trial - VIP report no. 1. Ophthalmology, no. 108, pp. 841-852, 2001
    BibTeX Link
    @article{Birngruber2001,
       author = {Arnold, J. and Kilmartin, D. and Olson, J. and Neville, S. and Robinson, K. and Birngruber, R. and  Laird, A. and Richmond, C. and Farrow, A. and McKay, S. and Saperstein, D. A. and Aaberg, T. M. and Johnson, J. B. and Waldron, R. and Loupe, D. and Gillman, J. and Myles, B. and Schachat, A. P. and Bressler, N. M. and Bressler, S. B. and Nesbitt, P. and Porter, T. and Hawse, P. and Hartnett, M. and Eager, A. and Belt, J. and Cain, D. and Emmert, D. and George, T. and Herring, M. and McDonald, J. and Mones, J. and Corcostegui, B. and Gilbert, M. and Duran, N. and Sisquella, M. and Nolla, A. and Margalef, A. and Miller, J. W. and Gragoudas, E. S. and Lane, A. M. and Emmanuel, N. and Holbrook, A. and Evans, C. and Lord, U. S. and Walsh, D. K. and Callahan, C. D. and DuBois, J. L. and Lewis, H. and Kaiser, P. K. and Holody, L. J. and Lesak, E. and Lichterman, S. and Siegel, H. and Fattori, A. and Ambrose, G. and Fecko, T. and Ross, D. and Burke, S. and Singerman, L. and Zegarra, H. and Novak, M. and Bartel, M. and Tilocco-DuBois, K. and Iic, M. and Schura, S. and Mayes, S. J. and Tanner, V. and Rowe, P. and Smith-Brewer, S. and Kukula, D. and Greanoff, G. and Daley, G. and DuBois, J. and Lehnhardt, D. and Fish, G. E. and Jost, B. F. and Anand, R. and Callanan, D. and Arceneaux, S. and Arnwine, J. and Ellenich, P. and King, J. and Aguado, H. and Rollins, R. and Jurklies, B. and Pauleikhoff, D. and Hintzmann, A. and Fischer, M. and Sowa, C. and Behne, E. and Pournaras, C. J. and Donati, G. and Kapetanios, A. D. and Cavaliere, K. and Guney-Wagner, S. and Gerber, N. and Sickenberg, M. and Sickenberg, V. and Gans, A. and Hosner, B. and others },
       title = {Photodynamic therapy of subfoveal choroidal neovascularization in pathologic myopia with verteporfin - 1-year results of a randomized clinical trial - VIP report no. 1},
       journal = {Ophthalmology},
       volume = {108},
       number = {5},
       pages = {841-852},
       note = {425WW
    Times Cited:272
    Cited References Count:12},
       abstract = {Objective: To determine if photodynamic therapy with verteporfin (Visudyne; CIBA Vision Corp, Duluth, GA) can improve the chance of stabilizing or improving vision (<8 letter loss) safely in patients with subfoveal choroidal neovascularization (CNV) caused by pathologic myopia.
    Design: Multicenter, double-masked, placebo-controlled, randomized clinical trial at 28 ophthalmology practices in Europe and North America.
    Participants: One hundred twenty patients with subfoveal CNV caused by pathologic myopia with a greatest linear dimension no more than 5400 <mu>m and best-corrected visual acuity (Snellen equivalent) of approximately 20/100 or better.
    Intervention: Patients were randomly assigned (2:1) to verteporfin (6 mg per square meter of body surface area; n = 81) or placebo (5% dextrose in water, n = 39) administered via intravenous infusion of 30 ml over 10 minutes. Fifteen minutes after the start of the infusion, a laser light at 689 nm was delivered at an intensity of 600 mW/cm(2) over 83 seconds to give a light dose of 50 J/cm(2) to a round spot size on the retina with a diameter of 1000 mum larger than the greatest linear dimension of the choroidal neovascular lesion. At follow-up examinations every 3 months, retreatment with either verteporfin or placebo (as assigned at baseline) was applied to areas of fluorescein leakage if present.
    Main Outcome Measures: The primary outcome was the proportion of eyes at the follow-up examination 12 months after study entry with fewer than eight letters (approximately 1.5 lines) of visual acuity lost, adhering to an intent-to-treat analysis.
    Results: At baseline, move than 90% of each group had evidence of classic CNV (regardless of whether occult CNV was present) and only 12 (15%) and 5 (13%) cases in the verteporfin and placebo groups, respectively, had occult CNV (regardless of whether classic CNV was present). Seventy-nine of the 81 verteporfin-treated patients (98%) compared with 36 of the 39 placebo-treated patients (92%) completed the month 12 examination. Visual acuity, contrast sensitivity, and fluorescein angiographic outcomes were better in the verteporfin-treated eyes than in the placebo-treated eyes at every follow-up examination through the month 12 examination. At the month 12 examination, 58 (72%) of the verteporfin-treated patients compared with 17 (44%) of the placebo-treated patients lost fewer than eight letters (P < 0.01), including 26 (32%) versus 6 (15%) improving at least five letters (<greater than or equal to>1 line). Seventy (86%) of the verteporfin-treated patients compared with 26 (67%) of the placebo-treated patients lost fewer than 15 letters (P = 0.01), Few ocular or other systemic adverse events were associated with verteporfin therapy compared with placebo treatment.
    Conclusions: Because photodynamic therapy with verteporfin can safely increase the chance of stabilizing or improving vision in patients with subfoveal CNV from pathologic myopia compared with a placebo, we recommend ophthalmologists consider verteporfin therapy for treatment of such patients. Ophthalmology 2001; 108:841-852 (C) 2001 by the American Academy of Ophthalmology.},
       ISSN = {0161-6420},
       url = {<Go to ISI>://WOS:000168315500020},
       year = {2001},
       type = {Journal Article}
    }
    
  • Vogel, A. and Noack, J.: Numerical simulation of optical breakdown for cellular surgery at nanosecond to femtosecond time scales. Laser- Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy. SPIE, no. 4433, pp. 70-80, 2001
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Noack, J.},
       title = {Numerical simulation of optical breakdown for cellular surgery at nanosecond to femtosecond time scales},
       journal = {Laser- Tissue Interactions, Therapeutic Applications, and Photodynamic Therapy. SPIE},
       volume = {4433},
       pages = {70-80},
       year = {2001}
    }
    
  • Huber, Robert and Satzger, Helmut and Zinth, Wolfgang and Wachtveitl, Josef: Noncollinear optical parametric amplifiers with output parameters improved by the application of a white light continuum generated in CaF2. Optics Communications, no. 194, pp. 443-448, jul,, 2001
    BibTeX Link
    @Article{HU_2001_Huber_a,
      Title                    = {{Noncollinear optical parametric amplifiers with output parameters improved by the application of a white light continuum generated in CaF2}},
      Author                   = {Huber, Robert and Satzger, Helmut and Zinth, Wolfgang and Wachtveitl, Josef},
      Journal                  = {Optics Communications},
      Year                     = {2001},
    
      Month                    = jul,
      Number                   = {4-6},
      Pages                    = {443--448},
      Volume                   = {194},
    
      Doi                      = {10.1016/S0030-4018(01)01324-4},
      ISSN                     = {00304018},
      Url                      = {http://linkinghub.elsevier.com/retrieve/pii/S0030401801013244}
    }
  • Hüttmann, G. and Serbin, J. and Radt, B. and Lange, B.I. and Birngruber, R.: Model system for investigating laser-induced subcellular microeffects.. Proc SPIE, no. 4257, pp. 398-409, 2001
    BibTeX
    @article{Hüttmann,
       author = {Hüttmann, G. and Serbin, J. and Radt, B. and Lange, B.I. and Birngruber, R.},
       title = {Model system for investigating laser-induced subcellular microeffects.},
       journal = {Proc SPIE},
       volume = {4257},
       pages = {398-409},
       year = {2001}
    }
    
  • Vogel, A. and Schmidt, P. and Flucke, B.: Minimization of thermomechanical side effects in IR ablation by use of Q-switched double pulses. Laser-Tissue Interaction XII. SPIE, no. 4257, pp. 184-191, 2001
    BibTeX
    @article{Vogel,
       author = {Vogel, A. and Schmidt, P. and Flucke, B.},
       title = {Minimization of thermomechanical side effects in IR ablation by use of Q-switched double pulses},
       journal = {Laser-Tissue Interaction XII. SPIE},
       volume = {4257},
       pages = {184-191},
       year = {2001}
    }
    
  • Elsner, H. G. and Niemeyer, M. and Birngruber, R. and Laqua, H. and Schmidt-Erfurth, U.: Imaging of choroidal neovascularization: A comparison of optical coherence tomography and topographic angiography.. Investigative Ophthalmology & Visual Science, no. 42, pp. S795-S795, 2001
    BibTeX Link
    @article{Elsner2001,
       author = {Elsner, H. G. and Niemeyer, M. and Birngruber, R. and Laqua, H. and Schmidt-Erfurth, U.},
       title = {Imaging of choroidal neovascularization: A comparison of optical coherence tomography and topographic angiography.},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {42},
       number = {4},
       pages = {S795-S795},
       note = {Suppl. S
    427EP
    4262
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000168392104225},
       year = {2001},
       type = {Journal Article}
    }
    
  • Yanagihara, N. and Miura, Y. and Moriwaki, M. and Shiraki, K. and Imamura, H. and Kaida, M. and Miki, T.: Hepatocyte growth factor promotes epithelial morphogenesis and occludin linkage to the cytoskeleton in cultured retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol, no. 239, pp. 619-27, 2001
    BibTeX
    @article{Miura2001,
       author = {Yanagihara, N. and Miura, Y. and Moriwaki, M. and Shiraki, K. and Imamura, H. and Kaida, M. and Miki, T.},
       title = {Hepatocyte growth factor promotes epithelial morphogenesis and occludin linkage to the cytoskeleton in cultured retinal pigment epithelial cells},
       journal = {Graefes Arch Clin Exp Ophthalmol},
       volume = {239},
       number = {8},
       pages = {619-27},
       note = {Yanagihara, N
    Miura, Y
    Moriwaki, M
    Shiraki, K
    Imamura, H
    Kaida, M
    Miki, T
    eng
    Research Support, Non-U.S. Gov't
    Germany
    2001/10/05 10:00
    Graefes Arch Clin Exp Ophthalmol. 2001 Aug;239(8):619-27.},
       abstract = {BACKGROUND: Although hepatocyte growth factor (HGF) is also known as scatter factor, it induces epithelial morphogenesis in cultured bovine retinal pigment epithelial (RPE) cells. To elucidate the mechanism of epithelial morphogenesis, we investigated the influence of HGF on occludin, a major component of tight junctions. METHODS: RPE cells were plated on collagen type 1-coated chamber slides or dishes, 20 ng/ml HGF was added and the cells were incubated for 1 week. Cells were harvested at several time-points, and occludin expression was examined by immunohistochemistry. Detergent extraction protocols to identify the intensity of occludin linkage to the cytoskeleton were also used. Occludin expression was determined semiquantitatively by Western blotting. RESULTS: Fluorescence microscopy revealed that HGF treatment increased the levels of insoluble occludin at the cell borders after detergent extraction. These level of insoluble occludin and the associated epithelial morphology were maintained for more than 3 weeks after withdrawal of HGF, whereas cells not treated with HGF had a fibroblastic appearance. Western blotting also showed that insoluble occludin was more abundant in HGF-treated cells. Furthermore, immunoreactive bands of insoluble occludin were somewhat larger than those of soluble occludin, suggesting that insoluble occludin may be modified in comparison to soluble occludin. CONCLUSION: Our results suggest that HGF promotes linkage of occludin to the cytoskeleton. HGF may become a therapeutic candidate in physiological recovery of RPE cells and in preparation of RPE monolayers for transplantation.},
       keywords = {Animals
    Blotting, Western
    Cattle
    Cells, Cultured
    Cytoskeleton/*metabolism
    Fluorescent Antibody Technique, Indirect
    Hepatocyte Growth Factor/*pharmacology
    Membrane Proteins/*metabolism
    Microscopy, Fluorescence
    Morphogenesis
    Occludin
    Pigment Epithelium of Eye/cytology/*drug effects/metabolism},
       year = {2001}
    }
    
  • Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Bastian, G. O. and Engelhardt, R. and Birngruber, R. and Laqua, H.: Examination of the cornea using optical coherence tomography. Ophthalmologe, no. 98, pp. 151-156, 2001
    BibTeX Link Link
    @article{Wirbelauer2001,
       author = {Wirbelauer, C. and Scholz, C. and Hoerauf, H. and Bastian, G. O. and Engelhardt, R. and Birngruber, R. and Laqua, H.},
       title = {Examination of the cornea using optical coherence tomography},
       journal = {Ophthalmologe},
       volume = {98},
       number = {2},
       pages = {151-156},
       note = {403KQ
    Times Cited:34
    Cited References Count:18},
       abstract = {Introduction. This study evaluated the clinical use of optical coherence tomography (OCT) for two-dimensional representation of the cornea.
    Patients and methods. Noncontact slit-lamp-adapted OCT was used in selected cases to evaluate pathologically altered corneas and to measure the central corneal thickness and curvature.
    Results. OCT provided correlation between differences in reflection and morphological changes. Scar tissue resulted in hyperreflective light scattering, wheras cystic lesions were hyporeflective. Precise biomorphometry also allowed representation of intrastromal and retrocorneal changes. Central corneal thickness measured by OCT yielded reproducible values and corn be calculated from the optical signals of the corneal surface.
    Conclusions. OCT provides high-resolution representation of the cornea and exact evaluation of its morphology, thickness, and curvature. Due to the noncontact, simple,and rapid examination using the slitlamp the corneal OCT method is a promising additional diagnostic modality.},
       keywords = {optical coherence tomography
    cornea
    pachymetry
    profilometry
    thickness measurements
    in-vivo
    pachymetry
    topography
    eye},
       ISSN = {0941-293X},
       DOI = {DOI 10.1007/s003470170176},
       url = {<Go to ISI>://WOS:000167041400005},
       year = {2001},
       type = {Journal Article}
    }
    
  • Brujan, EA. and Nahen, K. and Schmidt, P. and Vogel, A.: Dynamics of laser-induced cavitation bubbles near elastic boundary. J Fluid Mech, no. 433, pp. 251-281, 2001
    BibTeX
    @article{Brujan2001,
       author = {Brujan, EA. and Nahen, K. and Schmidt, P. and Vogel, A.},
       title = {Dynamics of laser-induced cavitation bubbles near elastic boundary},
       journal = {J Fluid Mech},
       volume = {433},
       pages = {251-281},
       year = {2001}
    }
    
  • Brujan, Emil-Alexandru and Nahen, Kester and Schmidt, Peter and Vogel, Alfred: Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus. Journal of Fluid Mechanics, no. 433, pp. 283-314, 2001
    BibTeX
    @article{Brujan2001,
       author = {Brujan, Emil-Alexandru and Nahen, Kester and Schmidt, Peter and Vogel, Alfred},
       title = {Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus},
       journal = {Journal of Fluid Mechanics},
       volume = {433},
       pages = {283-314},
       ISSN = {1469-7645},
       year = {2001},
       type = {Journal Article}
    }
    
  • Brinkmann, R. and Schuele, G. and Joachimmeyer, E. and Roider, J. and Birngruber, R.: Determination of absolute fundus temperatures during retinal laser photocoagulation and selective RPE treatment.. Investigative Ophthalmology & Visual Science, no. 42, pp. S696-S696, 2001
    BibTeX Link
    @article{Brinkmann2001,
       author = {Brinkmann, R. and Schuele, G. and Joachimmeyer, E. and Roider, J. and Birngruber, R.},
       title = {Determination of absolute fundus temperatures during retinal laser photocoagulation and selective RPE treatment.},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {42},
       number = {4},
       pages = {S696-S696},
       note = {Suppl. S
    427EP
    3749
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000168392103712},
       year = {2001},
       type = {Journal Article}
    }
    
  • Obana, A and Goto, Y and Miura, Y and Wada, S and Miki, T: Clinical findings and courses of age-related maculopathy.. Japanese Journal of Clinical Ophthalmology, no. 55, pp. 1229-1234, 2001
    BibTeX
    @article{Miura2001,
       author = {Obana, A and Goto, Y and Miura, Y and Wada, S and Miki, T},
       title = {Clinical findings and courses of age-related maculopathy.},
       journal = {Japanese Journal of Clinical Ophthalmology},
       volume = {55},
       number = {6},
       pages = {1229-1234},
       year = {2001}
    }
    
  • Framme, C. and Schuele, G. and Birngruber, R. and Brinkmann, R. and Roider, J.: Autofluorescence imaging after selective RPE laser treatment in macular diseases: A pilot study.. Investigative Ophthalmology & Visual Science, no. 42, pp. S703-S703, 2001
    BibTeX Link
    @article{Framme2001,
       author = {Framme, C. and Schuele, G. and Birngruber, R. and Brinkmann, R. and Roider, J.},
       title = {Autofluorescence imaging after selective RPE laser treatment in macular diseases: A pilot study.},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {42},
       number = {4},
       pages = {S703-S703},
       note = {Suppl. S
    427EP
    3785
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000168392103748},
       year = {2001},
       type = {Journal Article}
    }
    

2000

  • Huber, Robert and Spörlein, Sebastian and Moser, Jacques E and Grätzel, Michael and Wachtveitl, Josef: The Role of Surface States in the Ultrafast Photoinduced Electron Transfer from Sensitizing Dye Molecules to Semiconductor Colloids. The Journal of Physical Chemistry B, no. 104, pp. 8995-9003, American Chemical Society, sep,, 2000
    BibTeX Link
    @Article{HU_2000_Huber_a,
      Title                    = {{The Role of Surface States in the Ultrafast Photoinduced Electron Transfer from Sensitizing Dye Molecules to Semiconductor Colloids}},
      Author                   = {Huber, Robert and Sp\"{o}rlein, Sebastian and Moser, Jacques E and Gr\"{a}tzel, Michael and Wachtveitl, Josef},
      Journal                  = {The Journal of Physical Chemistry B},
      Year                     = {2000},
    
      Month                    = sep,
      Number                   = {38},
      Pages                    = {8995--9003},
      Volume                   = {104},
    
      Doi                      = {10.1021/jp9944381},
      ISSN                     = {1520-6106},
      Publisher                = {American Chemical Society},
      Url                      = {http://pubs.acs.org/doi/abs/10.1021/jp9944381}
    }
  • Huber, Robert and Spörlein, Sebastian and Moser, Jacques E and Grätzel, Michael and Wachtveitl, Josef: Surface States Control Ultrafast Electron Injection in Dye/Semiconductor Colloidal Systems. in Ultrafast Phenomena XII - Proceedings of the 12th International Conference, pp. 456-458, Springer-Verlag, Berlin - Heidelberg /Germany) - New York, Charleston, SC (USA), 2000
    BibTeX Link
    @InProceedings{HU_2000_Huber_b,
      Title                    = {{Surface States Control Ultrafast Electron Injection in Dye/Semiconductor Colloidal Systems}},
      Author                   = {Huber, Robert and Sp\"{o}rlein, Sebastian and Moser, Jacques E and Gr\"{a}tzel, Michael and Wachtveitl, Josef},
      Booktitle                = {Ultrafast Phenomena XII - Proceedings of the 12th International Conference},
      Year                     = {2000},
      Pages                    = {456--458},
      Publisher                = {Springer-Verlag, Berlin - Heidelberg /Germany) - New York, Charleston, SC (USA)},
      Series                   = {Springer Series in Chemical Physics},
    
      Doi                      = {10.1007/978-3-642-56546-5\_133},
      Url                      = {http://link.springer.com/chapter/10.1007\%2F978-3-642-56546-5\_133}
    }
  • Roider, J. and Brinkmann, R. and Wirbelauer, C. and Laqua, H. and Birngruber, R.: Subthreshold (retinal pigment epithelium) photocoagulation in macular diseases: a pilot study. Br J Ophthalmol, no. 84, pp. 40-7, 2000
    BibTeX
    @article{Roider,
       author = {Roider, J. and Brinkmann, R. and Wirbelauer, C. and Laqua, H. and Birngruber, R.},
       title = {Subthreshold (retinal pigment epithelium) photocoagulation in macular diseases: a pilot study},
       journal = {Br J Ophthalmol},
       volume = {84},
       number = {1},
       pages = {40-7},
       note = {0007-1161 (Print)
    Journal Article},
       abstract = {BACKGROUND: Subthreshold (retinal pigment epithelium) photocoagulation is a new photocoagulation method, which treats the retinal pigment epithelium (RPE) and avoids damage to the neural retina. The initial results in this prospective pilot study on various macular diseases are presented. METHODS: 12 patients with diabetic maculopathy (group I), 10 with soft drusen (group II), and four with central serous retinopathy (CSR) (group III) were treated and followed up for 1 year. Treatment was achieved using a train of repetitive short laser pulses (1.7 micros) of a green Nd:YLF laser (parameters: 527 nm, 100 and 500 pulses, repetition rate: 500 Hz, spot size: 160 microm, energies: 70-100 microJ). Laser energy was based on the visibility of test lesions on fluorescein angiography (50-130 microJ). Patients were examined at various times by ophthalmoscopy, fluorescein and ICG angiography, and infrared imaging. RESULTS: After 6 months hard exudates disappeared in six out of nine patients in group I and leakage disappeared in six out of 12 diabetic patients. In group II drusen were less in seven out of 10 patients. In group III serous detachment disappeared in three out of four cases. Visual acuity was stable in all cases. None of the laser lesions was clinically visible immediately. After 1 day most lesions were visible as yellowish RPE depigmentation. After 3 months some of the lesions were visible as hyperpigmented areas but most were not. Fluorescein angiography showed leakage only in the first week. Infrared imaging showed that most lesions can be visualised in groups I and II after a period longer than 1 week as hyperreflective areas. CONCLUSION: This study showed that subthreshold (RPE) photocoagulation is effective in some cases of diabetic maculopathy, drusens, and in CSR. Visibility of laser burns is not always necessary in the treatment of macular diseases presented here. Infrared imaging is an effective and non-invasive way of visualising subthreshold (RPE) laser burns.},
       keywords = {Aged
    Diabetic Retinopathy/surgery
    Female
    Fluorescein Angiography
    Follow-Up Studies
    Fundus Oculi
    Humans
    *Laser Coagulation
    Macular Degeneration/pathology/*surgery
    Male
    Middle Aged
    Pigment Epithelium of Eye/*surgery
    Pilot Projects
    Prospective Studies
    Retinal Drusen/surgery
    Treatment Outcome},
       year = {2000}
    }
    
  • Hoerauf, H. and Wirbelauer, C. and Scholz, C. and Engelhardt, R. and Koch, P. and Laqua, H. and Birngruber, R.: Slit-lamp-adapted optical coherence tomography of the anterior segment. Graefes Archive for Clinical and Experimental Ophthalmology, no. 238, pp. 8-18, 2000
    BibTeX Link Link
    @article{Hoerauf2000,
       author = {Hoerauf, H. and Wirbelauer, C. and Scholz, C. and Engelhardt, R. and Koch, P. and Laqua, H. and Birngruber, R.},
       title = {Slit-lamp-adapted optical coherence tomography of the anterior segment},
       journal = {Graefes Archive for Clinical and Experimental Ophthalmology},
       volume = {238},
       number = {1},
       pages = {8-18},
       note = {282FC
    Times Cited:77
    Cited References Count:19},
       abstract = {Purpose: To evaluate the diagnostic potential of a slit-lamp-adapted optical coherence tomography (OCT) system as an in vivo imaging device for routine clinical examination of the anterior segment of the eve.
    Patients and methods: In a pilot study, healthy volunteers and patients with different pathologies of the anterior segment were examined with a slit-lamp-adapted OCT system using 100-200 axial scans with 100-Hz line-scan frequency. The scan length is variable up to 7 mm, and the axial depth is 1.5 mm in tissue.
    Results: The slit-lamp-adapted OCT system allowed direct biomicroscopic imaging of the measured area. Anatomic structures and morphological changes anterior to the attenuating iris pigment epithelium could be visualized with high accuracy, Biometric analyses of the cornea, the chamber angle, the iris and secondary cataract were possible. Complete demonstration of the chamber angle was difficult clue to the backscattering properties of the anterior part of the sclera and the consequent shadowing of the most peripheral part of the iris.
    Conclusions: Slit-lamp-adapted OCT is a diagnostic tool which allows in vivo microscopic cross-sectional imaging of the anterior segment and precise measurement of ocular structures.},
       keywords = {in-vivo
    nerve
    eye},
       ISSN = {0721-832X},
       DOI = {DOI 10.1007/s004170050002},
       url = {<Go to ISI>://WOS:000085205300002},
       year = {2000},
       type = {Journal Article}
    }
    
  • Birngruber, R. and Schmidt-Erfurth, U. and Hasan, T.: Photodynamische Therapie der altersbedingten Makuladegeneration - Nichtthermische Laserbestrahlung aktiviert einen hochselektiven Photosensibilisator. LaserOpto, no. 32, pp. 66-70, 2000
    BibTeX
    @article{Birngruber2000,
       author = {Birngruber, R. and Schmidt-Erfurth, U. and Hasan, T.},
       title = {Photodynamische Therapie der altersbedingten Makuladegeneration - Nichtthermische Laserbestrahlung aktiviert einen hochselektiven Photosensibilisator},
       journal = {LaserOpto},
       volume = {32},
       pages = {66-70},
       year = {2000},
       type = {Journal Article}
    }
    
  • Roider, J. and Birngruber, R.: Patenting medical procedures - Reply. Archives of Ophthalmology, no. 118, pp. 1140-1140, 2000
    BibTeX Link
    @article{Roider2000,
       author = {Roider, J. and Birngruber, R.},
       title = {Patenting medical procedures - Reply},
       journal = {Archives of Ophthalmology},
       volume = {118},
       number = {8},
       pages = {1140-1140},
       note = {343KZ
    Times Cited:0
    Cited References Count:0},
       ISSN = {0003-9950},
       url = {<Go to ISI>://WOS:000088702700026},
       year = {2000},
       type = {Journal Article}
    }
    
  • Roider, J. and Birngruber, R.: Patenting medical procedures. Arch Ophthalmol, no. 118, pp. 1140, 2000
    BibTeX
    @article{Roider2000,
       author = {Roider, J. and Birngruber, R.},
       title = {Patenting medical procedures},
       journal = {Arch Ophthalmol},
       volume = {118},
       number = {8},
       pages = {1140},
       note = {0003-9950 (Print)
    Journal article},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10922219},
       year = {2000},
       type = {Journal Article}
    }
    
  • Schüle, G. and Hüttmann, G. and Roider, J. and Wirbelauer, C. and Birngruber, R. and Brinkmann, R.: Optoacoustic measurements during µs-irradiation of the retinal pigment epithelium. Proc. SPIE, no. 3914A, 2000
    BibTeX
    @article{Schüle,
       author = {Schüle, G. and Hüttmann, G. and Roider, J. and Wirbelauer, C. and Birngruber, R. and Brinkmann, R.},
       title = {Optoacoustic measurements during µs-irradiation of the retinal pigment epithelium},
       journal = {Proc. SPIE},
       volume = {3914A},
       year = {2000}
    }
    
  • Hüttmann, G. and Birngruber, R.: Laserinduzierte thermische Gewebseffekte mit mikroskopischer und makromolekularer Präzision. Z Med Phys, no. 10, pp. 169-174, 2000
    BibTeX
    @article{Hüttmann,
       author = {Hüttmann, G. and Birngruber, R.},
       title = {Laserinduzierte thermische Gewebseffekte mit mikroskopischer und makromolekularer Präzision},
       journal = {Z Med Phys},
       volume = {10},
       pages = {169-174},
       year = {2000}
    }
    
  • Hüttmann, G. and Radt, B. and Birngruber, R.: Laserinduzierte Mikro- und Nanoeffekte - Von der selektiven Thermolyse zu molekularen Nanoeffekten. LaserOpto, no. 32, pp. 47-55, 2000
    BibTeX
    @article{Hüttmann,
       author = {Hüttmann, G. and Radt, B. and Birngruber, R.},
       title = {Laserinduzierte Mikro- und Nanoeffekte - Von der selektiven Thermolyse zu molekularen Nanoeffekten},
       journal = {LaserOpto},
       volume = {32},
       pages = {47-55},
       year = {2000}
    }
    
  • Brinkmann, R. and Radt, B. and Flamm, C. and Kampmeier, J. and Koop, N. and Birngruber, R.: Influence of temperature and time on thermally induced forces in corneal collagen and the effect on laser thermokeratoplasty. J Cataract Refract Surg, no. 26, pp. 744-54, 2000
    BibTeX Link
    @article{Brinkmann2000,
       author = {Brinkmann, R. and Radt, B. and Flamm, C. and Kampmeier, J. and Koop, N. and Birngruber, R.},
       title = {Influence of temperature and time on thermally induced forces in corneal collagen and the effect on laser thermokeratoplasty},
       journal = {J Cataract Refract Surg},
       volume = {26},
       number = {5},
       pages = {744-54},
       note = {0886-3350 (Print)
    Journal Article
    Research Support, Non-U.S. Gov't},
       abstract = {PURPOSE: To investigate thermomechanical aspects of corneal collagen denaturation as a function of temperature and time and the effect of the induced forces on refractive changes with laser thermokeratoplasty (LTK). SETTING: Medical Laser Center Lubeck, Lubeck, Germany. METHODS: In a material-test setup, porcine corneal strips were denatured in paraffin oil at various constant temperatures for 10 and 500 seconds, and the temporal course of the contractive forces was studied under isometric conditions. Typical LTK lesions were performed in porcine eyes in vitro with a continuous-wave infrared laser diode at a wavelength of 1.87 microm for 10 and 60 seconds. The laser power was chosen to achieve comparable denatured volumes at both irradiation times. The refractive changes were measured and analyzed by histologic evaluations and temperature calculations. RESULTS: The time course of the induced forces was characterized by a maximal force, which increased almost linearly with temperature, and a residual lower force. After 500 seconds of heating, the highest force was achieved with a temperature of 75 degrees C. With a limited heating period of only 10 seconds, the forces steadily increased with temperature over the entire observation period. Laser thermokeratoplasty produced less refractive change after 10 seconds of irradiation than after 60 seconds, although the laser power was 25% higher in the short heating period. Polarization light microscopy of LTK lesions revealed different stages of thermal damage. CONCLUSION: The course of the contractive forces during and after heating is a complicated function of the spatial time/temperature profile. Laser thermokeratoplasty lesions produced with 2 irradiation times showed different stages of denaturation and induced refractive change.},
       keywords = {Animals
    Body Temperature
    Collagen/*metabolism
    Cornea/metabolism/pathology/*surgery
    *Laser Coagulation
    Microscopy, Polarization
    Protein Denaturation
    Swine
    Time Factors},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10831907},
       year = {2000},
       type = {Journal Article}
    }
    
  • Hoerauf, H. and Gordes, R. S. and Scholz, C. and Wirbelauer, C. and Koch, P. and Engelhardt, R. and Winkler, J. and Laqua, H. and Birngruber, R.: First experimental and clinical results with transscleral optical coherence tomography. Ophthalmic Surg Lasers, no. 31, pp. 218-22, 2000
    BibTeX
    @article{Hoerauf,
       author = {Hoerauf, H. and Gordes, R. S. and Scholz, C. and Wirbelauer, C. and Koch, P. and Engelhardt, R. and Winkler, J. and Laqua, H. and Birngruber, R.},
       title = {First experimental and clinical results with transscleral optical coherence tomography},
       journal = {Ophthalmic Surg Lasers},
       volume = {31},
       number = {3},
       pages = {218-22},
       note = {Hoerauf, H
    Gordes, R S
    Scholz, C
    Wirbelauer, C
    Koch, P
    Engelhardt, R
    Winkler, J
    Laqua, H
    Birngruber, R
    Comparative Study
    United states
    Ophthalmic Surg Lasers. 2000 May-Jun;31(3):218-22.},
       abstract = {BACKGROUND AND OBJECTIVE: To evaluate the potentials of optical coherence tomagraphy (OCT) using long wavelength to penetrate highly scattering tissues of the eye and visualize the anterior chamber angle and the ciliary body. METHODS: OCT images were generated by an experimental prototype in enucleated porcine eyes using as light source a superluminiscent diode with a wavelength of 1310 nm and a scan frequency of 60 Hz. The number of lateral scans was variable in a range from 100 to 400. RESULTS: Infrared OCT was able to penetrate the sclera. The anterior chamber angle could be visualized completely and the ciliary body could be identified. However, it was not possible to penetrate the highly reflective iris pigment epithelium. CONCLUSION: The use of infrared OCT allows penetration of the sclera, thus, providing complete visualization of the anterior chamber angle and limited demonstration of the ciliary body. Because of its higher resolution, it may represent an interesting noninvasive alternative to ultrasound biomicroscopy.},
       keywords = {Animals
    Anterior Chamber/ anatomy & histology
    Ciliary Body/ anatomy & histology
    Diagnostic Techniques, Ophthalmological
    Humans
    Interferometry
    Iris/ anatomy & histology
    Light
    Pigment Epithelium of Eye/cytology
    Reference Values
    Sclera
    Swine
    Tomography/ methods},
       year = {2000}
    }
    
  • Hoerauf, H. and Gordes, R. and Scholz, C. and Koch, P. and Engelhardt, R. and Wirbelauer, C. and Laqua, H. and Birngruber, R.: First experimental and clinical results of transscleral OCT. Investigative Ophthalmology & Visual Science, no. 41, pp. S786-S786, 2000
    BibTeX Link
    @article{Hoerauf2000,
       author = {Hoerauf, H. and Gordes, R. and Scholz, C. and Koch, P. and Engelhardt, R. and Wirbelauer, C. and Laqua, H. and Birngruber, R.},
       title = {First experimental and clinical results of transscleral OCT},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {41},
       number = {4},
       pages = {S786-S786},
       note = {Suppl. S
    300HF
    4171B118
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000086246704240},
       year = {2000},
       type = {Journal Article}
    }
    
  • Teschner, S. and Noack, J. and Birngruber, R. and Schmidt-Erfurth, U.: Documentation of perfusion and leakage characteristics in age-related macular degeneration by dynamic topographic angiography. Investigative Ophthalmology & Visual Science, no. 41, pp. S170-S170, 2000
    BibTeX Link
    @article{Teschner2000,
       author = {Teschner, S. and Noack, J. and Birngruber, R. and Schmidt-Erfurth, U.},
       title = {Documentation of perfusion and leakage characteristics in age-related macular degeneration by dynamic topographic angiography},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {41},
       number = {4},
       pages = {S170-S170},
       note = {Suppl. S
    300HF
    882b257
    Times Cited:0
    Cited References Count:0},
       ISSN = {0146-0404},
       url = {<Go to ISI>://WOS:000086246700881},
       year = {2000},
       type = {Journal Article}
    }
    
  • Meyer, C. and Hoerauf, H. and Schmidt-Erfurth, U. and Roider, J. and Scholz, C. and Laqua, H. and Birngruber, R.: Correlation of morphologic changes between optical coherence tomography and topographic angiography in a case of gyrate atrophy. Ophthalmologe, no. 97, pp. 41-46, 2000
    BibTeX Link Link
    @article{Meyer2000,
       author = {Meyer, C. and Hoerauf, H. and Schmidt-Erfurth, U. and Roider, J. and Scholz, C. and Laqua, H. and Birngruber, R.},
       title = {Correlation of morphologic changes between optical coherence tomography and topographic angiography in a case of gyrate atrophy},
       journal = {Ophthalmologe},
       volume = {97},
       number = {1},
       pages = {41-46},
       note = {283HG
    Times Cited:5
    Cited References Count:10},
       abstract = {Purpose:To characterize ultrastrructual changes in atrophic disease of the retina, RPE and choroid as seen with gyrate atrophy using two new diagnostic modalities, optical coherence tomography (OCT) and topographic angiography.
    Patient and method: OCT images were taken in a patient with pericentral choroidal atrophy using a slit-lamp-adapted OCT system. Ophthalmoscopy, conventional and topographic angiographic findings were correlated to the reflectivity changes as seen an OCT.
    Results:Areas of chorioretinal atrophy correlated with a loss of reflectivity in the RPE-choriocapillaris complex on OCT. Additionally OCT identified a thinning of the nerve fiber layer. Topographic angiography demonstrated an extensive defect, seen as an area of depression, consistent with a loss of choriocapillaris and larger-sized choroidal vessels. In contrast to conventional angiography, central islands were not found to demonstrate structural intensity, while the midperipheral surrounding area was clearly elevated to physiological levels.
    Conclusion: OCT and topographic angiography provide in vivo insight into morphologic changes within neurosensory retina and choroid caused by pericentral choroidal atrophy.},
       keywords = {optical coherence tomography
    topographic aniography
    pericentral choroidal atrophy
    ornithine},
       ISSN = {0941-293X},
       DOI = {DOI 10.1007/s003470050009},
       url = {<Go to ISI>://WOS:000085269900009},
       year = {2000},
       type = {Journal Article}
    }
    
  • Wirbelauer, C. and Koop, N. and Tuengler, A. and Geerling, G. and Birngruber, R. and Laqua, H. and Brinkmann, R.: Corneal endothelial cell damage after experimental diode laser thermal keratoplasty. J Refract Surg, no. 16, pp. 323-9, 2000
    BibTeX
    @article{Wirbelauer2000,
       author = {Wirbelauer, C. and Koop, N. and Tuengler, A. and Geerling, G. and Birngruber, R. and Laqua, H. and Brinkmann, R.},
       title = {Corneal endothelial cell damage after experimental diode laser thermal keratoplasty},
       journal = {J Refract Surg},
       volume = {16},
       number = {3},
       pages = {323-9},
       note = {Wirbelauer, C
    Koop, N
    Tuengler, A
    Geerling, G
    Birngruber, R
    Laqua, H
    Brinkmann, R
    Journal Article
    United States
    J Refract Surg. 2000 May-Jun;16(3):323-9.},
       abstract = {PURPOSE: To evaluate the safety of diode laser thermal keratoplasty (LTK) with respect to corneal endothelial cell damage. METHODS: In an in vitro animal model system, porcine eyes were irradiated with a continuously emitting laser diode at wavelengths (lambda) of 1.85 or 1.87 microm, corresponding to an absorption coefficient (micro(a)) of 1.1 or 2.0 mm(-1). Different irradiation and application parameters were tested serially. To determine the temperature threshold for endothelial damage, corneal buttons were analyzed separately in a waterbath experiment. The endothelial damage was assessed after trypan blue and alizarin red supravital staining under light microscopy. RESULTS: The thresholds for the 50% probability of thermal damage (ED50) were determined at corneal temperatures of 65 degrees C for a 10-second water-bath immersion, and 59 degrees C for 60 seconds. Coagulations that reached the deeper stromal layers revealed severe endothelial cellular alterations and areas of exposed Descemet's membrane. The thermally induced changes were dependent on laser power and the absorption coefficient (wavelength). Mean diameter of total endothelial cell damage was 245 +/- 154 microm (range, 0 to 594 microm) for an absorption coefficient of 1.1 mm(-1). The maximal lateral extent of endothelial cell damage induced by the laser exposure was 594 microm in diameter. Increasing the absorption coefficient decreased the penetration depth of the laser irradiation, creating a greater temperature rise within the corneal stroma and significantly less endothelial damage (P < .01), when the same laser power was applied. The calculated total area of damage for the paracentral human corneal endothelium ranged from 1.8% to 13.6%. CONCLUSION: Data obtained in this in vitro study were transferred to an endothelial cell damage nomogram, demonstrating that appropriate parameter improvements can minimize the adverse effects to the corneal endothelium. However, model adjustment to the human cornea indicates the potential for endothelial cell damage after diode laser thermal keratoplasty, and should be considered when performing this elective procedure.},
       keywords = {Animals
    Anthraquinones
    Cell Count
    Cell Survival
    Corneal Diseases/*etiology/pathology
    Corneal Stroma/*surgery
    Endothelium, Corneal/*pathology
    Laser Coagulation/*adverse effects/methods
    Necrosis
    Safety
    Swine
    Trypan Blue},
       ISSN = {1081-597X (Print)
    1081-597x},
       year = {2000},
       type = {Journal Article}
    }
    
  • Birngruber, R. and Schmidt-Erfurth, U. and Teschner, S. and Noack, J.: Confocal laser scanning fluorescence topography: a new method for three-dimensional functional imaging of vascular structures. Graefes Archive for Clinical and Experimental Ophthalmology, no. 238, pp. 559-565, 2000
    BibTeX Link Link
    @article{Birngruber2000,
       author = {Birngruber, R. and Schmidt-Erfurth, U. and Teschner, S. and Noack, J.},
       title = {Confocal laser scanning fluorescence topography: a new method for three-dimensional functional imaging of vascular structures},
       journal = {Graefes Archive for Clinical and Experimental Ophthalmology},
       volume = {238},
       number = {7},
       pages = {559-565},
       note = {341NG
    Times Cited:10
    Cited References Count:16},
       abstract = {Three-dimensional topography of perfused vascular structures is possible via confocal laser scanning of intravascular fluorescence. The lateral resolution is given by the spot size of the scanning laser beam (optimally 10 mu m at the retina). The axial resolution, however, depends on the accuracy of detection of the surface of the fluorescent structure, which is typically one order of magnitude higher (30 mu m at the retina) than the confocal resolution. The vascular structure is stained with an appropriate fluorescent dye prior to the investigation using standard systemic dye injection. Confocal scanning of the fluorescence in planes of different depths within the vascular structure under investigation leads to a three-dimensional data set. Signal processing in eludes passive eye tracking, lateral averaging and axial determination of the surface of the fluorescent structure. The potential of this new technique is demonstrated by showing the topography of physiological vessel structures as well as of selected vascular diseases such as cone dystrophy, RPE detachment, choroidal haemangioma and retinal laser coagulation. Confocal laser angioscopic fluorescence topography (CLAFT) measures the three-dimensional surface structure of functional (perfused) vasculature and surrounding leakage. CLAFT may help to diagnose and quantify status and time course of vascular diseases.},
       keywords = {in-vivo
    ophthalmoscope
    therapy},
       ISSN = {0721-832X},
       DOI = {DOI 10.1007/s004179900059},
       url = {<Go to ISI>://WOS:000088596000003},
       year = {2000},
       type = {Journal Article}
    }
    
  • Nahen, Kester and Eisenbeiß, Werner and Vogel, Alfred: Akustische Online-Kontrolle der Er: YAG Laserablation verbrannter Haut. Biomedizinische Technik/Biomedical Engineering, no. 45, pp. 300-301, 2000
    BibTeX
    @article{Nahen2000,
       author = {Nahen, Kester and Eisenbeiß, Werner and Vogel, Alfred},
       title = {Akustische Online-Kontrolle der Er: YAG Laserablation verbrannter Haut},
       journal = {Biomedizinische Technik/Biomedical Engineering},
       volume = {45},
       number = {s1},
       pages = {300-301},
       ISSN = {1862-278X},
       year = {2000},
       type = {Journal Article}
    }