1976- 1973

1976

  • Gabel, V. P. and Birngruber, R. and Hillenkamp, F. and Boergen, K. P.: Ophthalmoscopic Therapeutic Problems and Laser Personnel. Klinische Monatsblatter Fur Augenheilkunde, no. 169, pp. 669-669, 1976
    BibTeX
    @article{Gabel1976,
       author = {Gabel, V. P. and Birngruber, R. and Hillenkamp, F. and Boergen, K. P.},
       title = {Ophthalmoscopic Therapeutic Problems and Laser Personnel},
       journal = {Klinische Monatsblatter Fur Augenheilkunde},
       volume = {169},
       number = {5},
       pages = {669-669},
       note = {Cq473
    Times Cited:0
    Cited References Count:0},
       ISSN = {0023-2165},
       url = {<Go to ISI>://WOS:A1976CQ47300042},
       year = {1976},
       type = {Journal Article}
    }
    
  • Diddens, H. and Zahner, H. and Kraas, E. and Gohring, W. and Jung, G.: On the transport of tripeptide antibiotics in bacteria. Eur J Biochem, no. 66, pp. 11-23, 1976
    BibTeX
    @article{
       author = {Diddens, H. and Zahner, H. and Kraas, E. and Gohring, W. and Jung, G.},
       title = {On the transport of tripeptide antibiotics in bacteria},
       journal = {Eur J Biochem},
       volume = {66},
       number = {1},
       pages = {11-23},
       note = {Diddens, H
    Zahner, H
    Kraas, E
    Gohring, W
    Jung, G
    GERMANY, WEST
    Eur J Biochem. 1976 Jun 15;66(1):11-23.},
       abstract = {The two tripeptide antibiotics L-2-amino-4-methylphosphinobutyryl-alanyl-alanyl-alanine (L-phosphinothricyl-alanyl-alanine) and L-(N5-phosphono)methionine-S-sulfoximinyl-alanyl-alanine, both inhibitors of the glutamine synthetase, are transported into the cell of Escherichia coli K 12 via the oligopeptide transport system. The uptake by this system is proved first of all by cross-resistance with tri-L-ornithine using oligopeptide-transport-deficient mutants, and secondly by antagonism tests demonstrating competitive reversal of the action of the antibiotic by several peptides which have been shown to be transported via the oligopeptide transport system, e.g. tri-L-alanine, tetra-L-alanine, tri-L-lysine, tri-L-serine, tri-glycine, glycyl-glycyl-L-alanine and the synthetic tripeptide L-azadenyl-aminohexanoyl-alanyl-alanine. On the other hand, there is no effect on the action of the antibiotic in antagonism tests with compounds which use different transport systems, such as L-alanyl-alanine, L-lysyl-lysine, glutathione and the synthetic amino acid azaadenylaminohexanoic acid, i.e. 2-amino-6-(7-amino-3H-v-triazolo-[4,5-d]-pyrimidin-3-yl)hexanoic acid. Another inhibitor of the glutamine synthetase, L-methionine-S-dioxide (methioninesulfone) could be converted into a tripeptide form by linkage to L-alanyl-alanine analogously to the tripeptide antibiotics described above. Whereas the free L-methionine-S-dioxide seems to be transported via the methionine transport system, the tripeptide form is transported via the oligopeptide transport system. Thus, this glutamine synthetase inhibitor can be taken up by the cell via two different transport mechanisms. Our results indicate that this could provide a synergistic effect. The syntheses of the new tripeptides L-azaadenylaminohexanoyl-alanyl-alanine and L-methionine-S-dioxidyl-alanyl-alanine were performed by dicyclohexylcarbodiimide couplings of the unusual N-protected L-alpha-amino acids azaadenylaminohexanoic acid and L-methionine-S-dioxide to L-alanyl-alanine-tert-butyl ester followed by common deprotection steps. Tri-L-ornithine was synthesized without carboxyl protection via two successive couplings of hydroxybenzotriazol esters of Nalpha-butoxycarbonyl-Ndelta-benzyloxycarbonyl-L-ornithine.},
       keywords = {Anti-Bacterial Agents/*metabolism/pharmacology
    Biological Transport
    Cell Survival/drug effects
    Diffusion
    Escherichia coli/drug effects/*metabolism
    Fourier Analysis
    Glutamate-Ammonia Ligase/antagonists & inhibitors
    Magnetic Resonance Spectroscopy
    Oligopeptides/chemical synthesis/*metabolism/pharmacology
    Protein Conformation
    Structure-Activity Relationship},
       year = {1976}
    }
  • Diddens, H. and Zähner, H. and Kraas, E. and Gohring, W. and Jung, G.: On the transport of tripeptide antibiotics in bacteria. Eur J Biochem, no. 66, pp. 11-23, 1976
    BibTeX Link
    @article{Diddens1976,
       author = {Diddens, H. and Zähner, H. and Kraas, E. and Gohring, W. and Jung, G.},
       title = {On the transport of tripeptide antibiotics in bacteria},
       journal = {Eur J Biochem},
       volume = {66},
       number = {1},
       pages = {11-23},
       note = {Diddens, H
    Zahner, H
    Kraas, E
    Gohring, W
    Jung, G
    GERMANY, WEST
    Eur J Biochem. 1976 Jun 15;66(1):11-23.},
       abstract = {The two tripeptide antibiotics L-2-amino-4-methylphosphinobutyryl-alanyl-alanyl-alanine (L-phosphinothricyl-alanyl-alanine) and L-(N5-phosphono)methionine-S-sulfoximinyl-alanyl-alanine, both inhibitors of the glutamine synthetase, are transported into the cell of Escherichia coli K 12 via the oligopeptide transport system. The uptake by this system is proved first of all by cross-resistance with tri-L-ornithine using oligopeptide-transport-deficient mutants, and secondly by antagonism tests demonstrating competitive reversal of the action of the antibiotic by several peptides which have been shown to be transported via the oligopeptide transport system, e.g. tri-L-alanine, tetra-L-alanine, tri-L-lysine, tri-L-serine, tri-glycine, glycyl-glycyl-L-alanine and the synthetic tripeptide L-azadenyl-aminohexanoyl-alanyl-alanine. On the other hand, there is no effect on the action of the antibiotic in antagonism tests with compounds which use different transport systems, such as L-alanyl-alanine, L-lysyl-lysine, glutathione and the synthetic amino acid azaadenylaminohexanoic acid, i.e. 2-amino-6-(7-amino-3H-v-triazolo-[4,5-d]-pyrimidin-3-yl)hexanoic acid. Another inhibitor of the glutamine synthetase, L-methionine-S-dioxide (methioninesulfone) could be converted into a tripeptide form by linkage to L-alanyl-alanine analogously to the tripeptide antibiotics described above. Whereas the free L-methionine-S-dioxide seems to be transported via the methionine transport system, the tripeptide form is transported via the oligopeptide transport system. Thus, this glutamine synthetase inhibitor can be taken up by the cell via two different transport mechanisms. Our results indicate that this could provide a synergistic effect. The syntheses of the new tripeptides L-azaadenylaminohexanoyl-alanyl-alanine and L-methionine-S-dioxidyl-alanyl-alanine were performed by dicyclohexylcarbodiimide couplings of the unusual N-protected L-alpha-amino acids azaadenylaminohexanoic acid and L-methionine-S-dioxide to L-alanyl-alanine-tert-butyl ester followed by common deprotection steps. Tri-L-ornithine was synthesized without carboxyl protection via two successive couplings of hydroxybenzotriazol esters of Nalpha-butoxycarbonyl-Ndelta-benzyloxycarbonyl-L-ornithine.},
       keywords = {Anti-Bacterial Agents/*metabolism/pharmacology
    Biological Transport
    Cell Survival/drug effects
    Diffusion
    Escherichia coli/drug effects/*metabolism
    Fourier Analysis
    Glutamate-Ammonia Ligase/antagonists & inhibitors
    Magnetic Resonance Spectroscopy
    Oligopeptides/chemical synthesis/*metabolism/pharmacology
    Protein Conformation
    Structure-Activity Relationship},
       year = {1976}
    }
    
  • Diddens, H. and Zähner, H. and Kraas, E. and Gohring, W. and Jung, G.: On the transport of tripeptide antibiotics in bacteria. Eur J Biochem, no. 66, pp. 11-23, 1976
    BibTeX Link
    @article{Diddens1976,
       author = {Diddens, H. and Zähner, H. and Kraas, E. and Gohring, W. and Jung, G.},
       title = {On the transport of tripeptide antibiotics in bacteria},
       journal = {Eur J Biochem},
       volume = {66},
       number = {1},
       pages = {11-23},
       note = {Diddens, H
    Zahner, H
    Kraas, E
    Gohring, W
    Jung, G
    GERMANY, WEST
    Eur J Biochem. 1976 Jun 15;66(1):11-23.},
       abstract = {The two tripeptide antibiotics L-2-amino-4-methylphosphinobutyryl-alanyl-alanyl-alanine (L-phosphinothricyl-alanyl-alanine) and L-(N5-phosphono)methionine-S-sulfoximinyl-alanyl-alanine, both inhibitors of the glutamine synthetase, are transported into the cell of Escherichia coli K 12 via the oligopeptide transport system. The uptake by this system is proved first of all by cross-resistance with tri-L-ornithine using oligopeptide-transport-deficient mutants, and secondly by antagonism tests demonstrating competitive reversal of the action of the antibiotic by several peptides which have been shown to be transported via the oligopeptide transport system, e.g. tri-L-alanine, tetra-L-alanine, tri-L-lysine, tri-L-serine, tri-glycine, glycyl-glycyl-L-alanine and the synthetic tripeptide L-azadenyl-aminohexanoyl-alanyl-alanine. On the other hand, there is no effect on the action of the antibiotic in antagonism tests with compounds which use different transport systems, such as L-alanyl-alanine, L-lysyl-lysine, glutathione and the synthetic amino acid azaadenylaminohexanoic acid, i.e. 2-amino-6-(7-amino-3H-v-triazolo-[4,5-d]-pyrimidin-3-yl)hexanoic acid. Another inhibitor of the glutamine synthetase, L-methionine-S-dioxide (methioninesulfone) could be converted into a tripeptide form by linkage to L-alanyl-alanine analogously to the tripeptide antibiotics described above. Whereas the free L-methionine-S-dioxide seems to be transported via the methionine transport system, the tripeptide form is transported via the oligopeptide transport system. Thus, this glutamine synthetase inhibitor can be taken up by the cell via two different transport mechanisms. Our results indicate that this could provide a synergistic effect. The syntheses of the new tripeptides L-azaadenylaminohexanoyl-alanyl-alanine and L-methionine-S-dioxidyl-alanyl-alanine were performed by dicyclohexylcarbodiimide couplings of the unusual N-protected L-alpha-amino acids azaadenylaminohexanoic acid and L-methionine-S-dioxide to L-alanyl-alanine-tert-butyl ester followed by common deprotection steps. Tri-L-ornithine was synthesized without carboxyl protection via two successive couplings of hydroxybenzotriazol esters of Nalpha-butoxycarbonyl-Ndelta-benzyloxycarbonyl-L-ornithine.},
       keywords = {Anti-Bacterial Agents/*metabolism/pharmacology
    Biological Transport
    Cell Survival/drug effects
    Diffusion
    Escherichia coli/drug effects/*metabolism
    Fourier Analysis
    Glutamate-Ammonia Ligase/antagonists & inhibitors
    Magnetic Resonance Spectroscopy
    Oligopeptides/chemical synthesis/*metabolism/pharmacology
    Protein Conformation
    Structure-Activity Relationship},
       year = {1976}
    }
    
  • Gabel, V. P. and Birngruber, R. and Hillenkamp, F.: Die Lichtabsorption am Augenhintergrund. Ges f Strahlen- und Umweltforschung, München, 1976
    BibTeX
    @book{Gabel1976,
       author = {Gabel, V. P. and Birngruber, R. and Hillenkamp, F.},
       title = {Die Lichtabsorption am Augenhintergrund},
       publisher = {Ges f Strahlen- und Umweltforschung},
       address = {München},
       series = {GSF-Bericht A 55},
       year = {1976}
    }
    
  • Lund, O. E. and Gabel, V. P. and Birngruber, Reginald: Diathermieverfahren, Licht-/Laserkoagulation, Kryokoagulation. Experimentelle und klinische Uberlegungen. Klin Monatsbl Augenheilkd, no. 168, pp. 603-12, 1976
    BibTeX Link
    @article{Lund1976,
       author = {Lund, O. E. and Gabel, V. P. and Birngruber, Reginald},
       title = {Diathermieverfahren, Licht-/Laserkoagulation, Kryokoagulation. Experimentelle und klinische Uberlegungen},
       journal = {Klin Monatsbl Augenheilkd},
       volume = {168},
       number = {05},
       pages = {603-12},
       note = {0023-2165 (Print)
    English Abstract
    Journal Article},
       abstract = {The clinical and experimental results from the methods of coagulation currently in use are presented. The advantages and disadvantages of trans-scleral methods (diathermy and cryopexy) and trans-ocular methods (Xenon arc and argon laser) are discussed. Experiments on absorption, the mode of action of intense light, the optimal time and method of application, the necessary intensity and the extent of the coagulated area are communicated. Of the trans-scleral methods, cryopexy is to be prefered. The trans-ocular methods have the advantage of a more exact localisation and dosage. Either route can often be chosen in any particular case, though at present no overriding advantage has been shown for either.},
       keywords = {*Cryosurgery/adverse effects/methods
    *Diathermy/adverse effects/methods
    Humans
    Lasers/adverse effects/methods/therapeutic use
    *Light Coagulation/adverse effects/methods
    Retina/pathology
    Retinal Detachment/*surgery
    Time Factors},
       year = {1976}
    }
    
  • Birngruber, R.: Audivisuelle Anlage der Augenklinik München. Grundig-Electronic-Information, 1976
    BibTeX
    @article{Birngruber1976,
       author = {Birngruber, R.},
       title = {Audivisuelle Anlage der Augenklinik München},
       journal = {Grundig-Electronic-Information},
       year = {1976},
       type = {Journal Article}
    }
    

1975

  • Lund, O. E. and Wallow, I. H. and Hillenkamp, F. and Birngruber, R. and Gabel, V. P.: Zur experimentellen Laser-Einwirkung am Auge. Sonderdruck aus Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelbert 1973, pp. 360-362, 1975
    BibTeX Link
    @article{BGB1973,
       author = {Lund, O. E. and Wallow, I. H. and Hillenkamp, F. and Birngruber, R. and Gabel, V. P.},
       title = {Zur experimentellen Laser-Einwirkung am Auge},
       journal = {Sonderdruck aus "Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelbert 1973"},
       number = {73},
       pages = {360-362},
       note = {0070-427X (Print)
    Journal Article},
       keywords = {*Accident Prevention
    Eye Injuries/*prevention & control
    Humans
    Lasers/*adverse effects/standards},
       year = {1975}
    }
    
  • Lund, O. E. and Wallow, I. H. and Hillenkamp, F. and Birngruber, R. and Gabel, V. P.: Zur experimentellen Laser-Einwirkung am Auge. Sonderdruck aus Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelbert 1973, pp. 360-362, 1975
    BibTeX Link
    @article{Lund1975,
       author = {Lund, O. E. and Wallow, I. H. and Hillenkamp, F. and Birngruber, R. and Gabel, V. P.},
       title = {Zur experimentellen Laser-Einwirkung am Auge},
       journal = {Sonderdruck aus "Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelbert 1973"},
       number = {73},
       pages = {360-362},
       note = {0070-427X (Print)
    Journal Article},
       keywords = {*Accident Prevention
    Eye Injuries/*prevention & control
    Humans
    Lasers/*adverse effects/standards},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1242947},
       year = {1975},
       type = {Journal Article}
    }
    
  • Birngruber, R. and Gabel, V. P. and Wallow, I. H. and Hillenkamp, F.: Über Rubin-Laserschwellenwertuntersuchungen an der Netzhaut. Sonderdruck aus Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973, pp. 367-74, 1975
    BibTeX Link
    @article{BGB1973,
       author = {Birngruber, R. and Gabel, V. P. and Wallow, I. H. and Hillenkamp, F.},
       title = {Über Rubin-Laserschwellenwertuntersuchungen an der Netzhaut},
       journal = {Sonderdruck aus "Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973"},
       number = {73},
       pages = {367-74},
       note = {0070-427X (Print)
    Journal Article},
       keywords = {Animals
    Haplorhini
    Lasers/adverse effects/*standards
    Rabbits
    Retina/injuries/*physiology},
       year = {1975}
    }
    
  • Birngruber, R. and Gabel, V. P. and Wallow, I. H. and Hillenkamp, F.: Über Rubin-Laserschwellenwertuntersuchungen an der Netzhaut. Sonderdruck aus Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973, pp. 367-74, 1975
    BibTeX Link
    @article{Birngruber1977,
       author = {Birngruber, R. and Gabel, V. P. and Wallow, I. H. and Hillenkamp, F.},
       title = {Über Rubin-Laserschwellenwertuntersuchungen an der Netzhaut},
       journal = {Sonderdruck aus "Bericht über die 73. Zusammenkunft der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973"},
       number = {73},
       pages = {367-74},
       note = {0070-427X (Print)
    Journal Article},
       keywords = {Animals
    Haplorhini
    Lasers/adverse effects/*standards
    Rabbits
    Retina/injuries/*physiology},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=812473},
       year = {1975},
       type = {Journal Article}
    }
    
  • Gabel, V. P. and Birngruber, R. and Hillenkamp, F. and Wallow, I. H. and Schmolke, W.: Über die Lichtabsorption am Augenhintergrund. Sonderdruck aus Bericht über die 73. Zusammenkunt der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973, pp. 362-7, 1975
    BibTeX Link
    @article{BGB1973,
       author = {Gabel, V. P. and Birngruber, R. and Hillenkamp, F. and Wallow, I. H. and Schmolke, W.},
       title = {Über die Lichtabsorption am Augenhintergrund},
       journal = {Sonderdruck aus "Bericht über die 73. Zusammenkunt der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973"},
       number = {73},
       pages = {362-7},
       note = {0070-427X (Print)
    Journal Article},
       keywords = {Absorption
    Animals
    Choroid/physiology
    *Fundus Oculi
    Haplorhini
    Humans
    *Light
    Rabbits
    Retina/physiology},
       year = {1975}
    }
    
  • Gabel, V. P. and Birngruber, R. and Hillenkamp, F. and Wallow, I. H. and Schmolke, W.: Über die Lichtabsorption am Augenhintergrund. Sonderdruck aus Bericht über die 73. Zusammenkunt der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973, pp. 362-7, 1975
    BibTeX Link
    @article{Gabel1975,
       author = {Gabel, V. P. and Birngruber, R. and Hillenkamp, F. and Wallow, I. H. and Schmolke, W.},
       title = {Über die Lichtabsorption am Augenhintergrund},
       journal = {Sonderdruck aus "Bericht über die 73. Zusammenkunt der Deutschen Ophthalm. Gesellschaft in Heidelberg 1973"},
       number = {73},
       pages = {362-7},
       note = {0070-427X (Print)
    Journal Article},
       keywords = {Absorption
    Animals
    Choroid/physiology
    *Fundus Oculi
    Haplorhini
    Humans
    *Light
    Rabbits
    Retina/physiology},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=812472},
       year = {1975},
       type = {Journal Article}
    }
    
  • Wallow, I. H. L. and Birngruber, R. and Gabel, V. P. and Hillenkamp, F. and Lund, O. E.: Retinal Reactions to Intense Light .1. Threshold Lesions - Experimental, Morphological and Clinical Studies of Pathological and Therapeutic Effects of Laser-Light and White-Light. Advances in Ophthalmology, no. 31, pp. 159-232, 1975
    BibTeX Link
    @article{Wallow1975,
       author = {Wallow, I. H. L. and Birngruber, R. and Gabel, V. P. and Hillenkamp, F. and Lund, O. E.},
       title = {Retinal Reactions to Intense Light .1. Threshold Lesions - Experimental, Morphological and Clinical Studies of Pathological and Therapeutic Effects of Laser-Light and White-Light},
       journal = {Advances in Ophthalmology},
       volume = {31},
       pages = {159-232},
       note = {Cz545
    Times Cited:23
    Cited References Count:151},
       url = {<Go to ISI>://WOS:A1975CZ54500004},
       year = {1975},
       type = {Journal Article}
    }
    
  • Wallow, I. H. and Birngruber, R. and Gabel, V. P. and Hillenkamp, F. and Lund, O. I.: Netzhautreaktionen nach Intensivlichtbestrahlung. Teil I: Schwellenlasionen. Experimentelle, morphologische und klinische Untersuchungen uber pathologische und therapeutische Wirkungen von Laserlicht und von weissem Licht. Adv Ophthalmol, no. 31, pp. 159-232, 1975
    BibTeX Link
    @article{BGB1975,
       author = {Wallow, I. H. and Birngruber, R. and Gabel, V. P. and Hillenkamp, F. and Lund, O. I.},
       title = {Netzhautreaktionen nach Intensivlichtbestrahlung. Teil I: Schwellenlasionen. Experimentelle, morphologische und klinische Untersuchungen uber pathologische und therapeutische Wirkungen von Laserlicht und von weissem Licht
    },
       journal = {Adv Ophthalmol},
       volume = {31},
       pages = {159-232},
       note = {0065-3004 (Print)
    Comparative Study
    English Abstract
    Journal Article},
       abstract = {The effects of intense light produced by an argon laser, a helium-neon laser and a xenon are photocoagulator in the retinas of gray chinchilla rabbits, cynomolgus monkeys, and rhesus monkeys were studied clinically and histopathologically including electron microscopy. An improved experimental set-up was used allowing a very good consistency of the inflicted lesions. Threshold lesions were produced in chinchilla rabbits and cynomolgus monkeys by an argon laser and a helium-neon laser. The lesions were evaluated ophthalmoscopically and histograms were drawn indicating ophthalmoscopic ED50 values. For the two lasers examined these values were 12 and 17 mW, respectively, for exposure durations in the range of the blink reflex (125-150 msec). Histopathologically, ophthalmoscopic threshold lesions of both laser types showed evidence of thermal damage of the outer retinal half. This damage was principally identical in both species involving the retinal pigment epithelium and the full extension of the photoreceptor cells up to their synapses within the outer plexiform layer. The ophthalmoscopic threshold value was associated, therefore, with an irreversible loss of visual function within the retinal area concerned. No evidence for primary sites of significant energy absorption within the neural retina was found. The width of ophthalmoscopic threshold lesions was determined by measuring within the histologic sections with a microscope and a calibrated graticule the extension of damage at the level of the retinal pigment epithelium and at the level of the outer nuclear layer. In the cynomolgus monkey for ophthalmoscopic argon laser threshold lesions the extension at the level of the RPE was 70-80 mum in diameter and at the level of the outer nuclear layer it was 40-50 mum in diameter. Laser lesions that had a diameter of 60 mum at the level of the RPE and of 30 mum at the level of the outer nuclear layer were ophthalmoscopically subvisible. It is concluded that probably also in man such laser lesions, as well as various other pathologic changes of this size or smaller, cannot be evaluated by clinical ophthalmoscopy. The ophthalmoscopic threshold was correlated with a histopathologic threshold as defined by minimal histopathologic damage. Very likely, such damage lies within the range of functional recovery, and the histopathologic threshold demarcates at the same time the decisive functional threshold. The conversion ratio between histopathologic-functional and ophthalmoscopic threshold for argon lesions in cynomolgus monkeys was somewhat greater than 3, e.i. the ophthalmoscopic threshold was more than 3 times higher than the histopathologic-functional threshold. Using this data together with additional biologic and optical considerations, a safety threshold for man for cw-lasers within the visible spectrum was estimated to be 1-2 mW.},
       keywords = {Animals
    Argon
    Fundus Oculi
    Haplorhini
    Helium
    Humans
    *Lasers/methods/*therapeutic use
    Macaca
    Macaca fascicularis
    Neon
    Pigment Epithelium of Eye/pathology/ultrastructure
    Rabbits
    Retina/pathology/*surgery/ultrastructure
    Retinal Diseases/*etiology/pathology},
       year = {1975}
    }
    
  • Greite, J. H. and Birngruber, R.: Low intensity argon laser coagulation in central serous retinopathy (csr). Ophthalmologica, no. 171, pp. 214-43, 1975
    BibTeX Link
    @article{Greite1975,
       author = {Greite, J. H. and Birngruber, R.},
       title = {Low intensity argon laser coagulation in central serous retinopathy (csr)},
       journal = {Ophthalmologica},
       volume = {171},
       number = {3},
       pages = {214-43},
       note = {0030-3755 (Print)
    Journal Article},
       abstract = {Mechanisms of light coagulation effects in RPE and detached retina are discussed. 25 cases of CSR are presented in which the leaking point in the RPE was coagulated with an argon laser coagulator, the exposure parameters being set to avoid a whitening of the retina. The results suggest that the retinal whitening and consequently retinal damage does not constitute a criterium for coagulation effectiveness in CSR.},
       keywords = {Adult
    *Argon
    Fluorescein Angiography
    Fundus Oculi
    Humans
    *Lasers/*therapeutic use
    Male
    Middle Aged
    Retinal Artery/radiography
    Retinal Detachment/*therapy
    Retinal Vein/radiography
    Retinal Vessels/radiography},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1169740},
       year = {1975},
       type = {Journal Article}
    }
    
  • Kinder, J. and Hutzler, P. and Birngruber, R.: Fernsehübertragung stereoskopischer Bilder. Biomed Techn, no. 20, pp. 297-298, 1975
    BibTeX
    @article{Kinder1975,
       author = {Kinder, J. and Hutzler, P. and Birngruber, R.},
       title = {Fernsehübertragung stereoskopischer Bilder},
       journal = {Biomed Techn},
       volume = {20},
       pages = {297-298},
       year = {1975},
       type = {Journal Article}
    }
    
  • Birngruber, R. and Gabel, V. P. and Hillenkamp, F.: Development of Laser Lesions in Fundus. Klinische Monatsblatter Fur Augenheilkunde, no. 167, pp. 624-624, 1975
    BibTeX
    @article{Birngruber1975,
       author = {Birngruber, R. and Gabel, V. P. and Hillenkamp, F.},
       title = {Development of Laser Lesions in Fundus},
       journal = {Klinische Monatsblatter Fur Augenheilkunde},
       volume = {167},
       number = {4},
       pages = {624-624},
       note = {Ay079
    Times Cited:0
    Cited References Count:0},
       ISSN = {0023-2165},
       url = {<Go to ISI>://WOS:A1975AY07900026},
       year = {1975},
       type = {Journal Article}
    }
    
  • Wallow, I. H. and Gabel, V. P. and Birngruber, R. and Hillenkamp, F.: [Clinical and histological studies following argon-laser effect on the retina. -Histo-pathological evaluation of laser injuries for the assessment of a functional injury threshold for lasers]. Ber Zusammenkunft Dtsch Ophthalmol Ges, pp. 374-86, 1975
    BibTeX Link
    @article{Wallow1975,
       author = {Wallow, I. H. and Gabel, V. P. and Birngruber, R. and Hillenkamp, F.},
       title = {[Clinical and histological studies following argon-laser effect on the retina. --Histo-pathological evaluation of laser injuries for the assessment of a functional injury threshold for lasers]},
       journal = {Ber Zusammenkunft Dtsch Ophthalmol Ges},
       number = {73},
       pages = {374-86},
       note = {0070-427X (Print)
    Journal Article},
       keywords = {Animals
    Argon
    Eye Injuries/*etiology/pathology
    Haplorhini
    Lasers/*adverse effects
    Retina/*injuries/pathology},
       url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=812474},
       year = {1975},
       type = {Journal Article}
    }
    

1974

  • Wallow, I. H. and Lund, O. E. and Gabel, V. P. and Birngruber, R. and Hillenkamp, F.: A comparison of retinal argon laser lesions in man and in cynomolgus monkey. Graefes Arch Klin Exp Ophthalmol, no. 189, pp. 159-64, 1974
    BibTeX Link
    @article{BGB1974,
       author = {Wallow, I. H. and Lund, O. E. and Gabel, V. P. and Birngruber, R. and Hillenkamp, F.},
       title = {A comparison of retinal argon laser lesions in man and in cynomolgus monkey},
       journal = {Graefes Arch Klin Exp Ophthalmol},
       volume = {189},
       number = {3},
       pages = {159-64},
       note = {0065-6100 (Print)
    Comparative Study
    Journal Article},
       keywords = {Animals
    Argon
    Choroid Neoplasms
    Diabetic Retinopathy/surgery
    Disease Models, Animal
    Epithelium/pathology
    Eye Injuries/pathology
    Fundus Oculi
    Haplorhini
    Humans
    *Lasers/*therapeutic use
    *Macaca
    Male
    Melanoma
    Middle Aged
    Ophthalmoscopy
    Photoreceptors/pathology
    Retina/*injuries},
       year = {1974}
    }