Publikationen

2022

  • Miura, Y;Inagaki, K;Hutfilz, A;Seifert, E;Schmarbeck, B;Murakami, A;Ohkoshi, K and Brinkmann, R: Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application. Life, no. 12(9), pp. 1313, 2022
    BibTeX Link
    @article{Miura2022,
       author = {Miura, Y;Inagaki, K;Hutfilz, A;Seifert, E;Schmarbeck, B;Murakami, A;Ohkoshi, K and Brinkmann, R},
       title = {Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application},
       journal = {Life},
       volume = {12(9)},
      
       pages = {1313},
       ISSN = {2075-1729},
       url = {https://www.mdpi.com/2075-1729/12/9/1313},
       year = {2022},
       type = {Journal Article}
    }
    

2021

  • Seifert, E;Abbas, H. S. and Brinkman, R: Single pulse optoacoustic temperature measurement. in ECBO, 2021
    BibTeX Link
    @inproceedings{Seifert2021,
       author = {Seifert, E;Abbas, H. S. and Brinkman, R},
       title = {Single pulse optoacoustic temperature measurement},
       booktitle = {ECBO},
    DOI = {10.1117/12.2615897},
    year = {2021},
       type = {Conference Proceedings}
    }
    
  • Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R: Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime. Investigative Ophthalmology & Visual Science, no. 62(3), pp. 32-32, 2021
    BibTeX Link Link
    @article{Seifert2021,
       author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R},
       title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime},
       journal = {Investigative Ophthalmology & Visual Science},
       volume = {62(3)},
      
       pages = {32-32},
       ISSN = {1552-5783},
       DOI = {10.1167/iovs.62.3.32},
       url = {https://doi.org/10.1167/iovs.62.3.32},
       year = {2021},
       type = {Journal Article}
    }
    
  • Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y: Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States. Life, no. 11(6), pp. 555, 2021
    BibTeX Link
    @article{Miura2021-2,o
       author = {Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y},
       title = {Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States},
       journal = {Life},
       volume = {11(6)},
      keywords = {retinal laser treatment; metabolic change; fluorescence lifetime imaging ophthalmoscopy},
       pages = {555},
       ISSN = {2075-1729},
       url = {https://www.mdpi.com/2075-1729/11/6/555},
       year = {2021},
       type = {Journal Article}
    }
    
  • Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R: Algorithms for optoacoustically controlled selective retina therapy (SRT). Photoacoustics, no. 25, pp. 100316, 2021
    BibTeX Link
    @article{Seifert2021,
       author = {Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R},
       title = {Algorithms for optoacoustically controlled selective retina therapy (SRT)},
       journal = {Photoacoustics},
    Keywords = {SRT; Lasers in medicine; Ophthalmology; RPE; Selectivity; Algorithm; Retina therapy; Optoacoustics; Feedback},
       volume = {25},
       pages = {100316},
       ISSN = {2213-5979},
       url = {https://www.sciencedirect.com/science/article/pii/S2213597921000756},
       year = {2021},
       type = {Journal Article}
    }
    

2019

  • Bliedtner, K;Seifert, E and Brinkmann, R: Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty. TVST 8(6), 2019
    BibTeX Link
    @article{Bliedtner2019,
       author = {Bliedtner, K;Seifert, E and Brinkmann, R},
       title = {Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty},
       journal = {TVST 8(6)},
      
       ISSN = {2164-2591},
       DOI = {10.1167/tvst.8.6.24},
       year = {2019},
       type = {Journal Article}
    }
    
  • Miura, Y;Seifert, E;Rehra, J;Kern, K;Theisen-Kunde, D;Denton, M and Brinkmann, R: Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study. Int J Hyperth, pp. 1-7, 2019
    BibTeX Link
    @article{Miura2019/4,
       author = {Miura, Y;Seifert, E;Rehra, J;Kern, K;Theisen-Kunde, D;Denton, M and Brinkmann, R},
       title = {Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study},
       journal = {Int J Hyperth},
       pages = {1-7},
       ISSN = {0265-6736},
      
       url = {https://doi.org/10.1080/02656736.2019.1590653},
       year = {2019},
       type = {Journal Article}
    }
    
  • Detrez, N;Miura, Y;Seifert, E;Theisen-Kunde, D and Brinkmann, R: Heating and optoacoustic temperature determination of cell cultures. in Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, no. 11079, SPIE, 2019
    BibTeX Link
    @inproceedings{Detrez2019,
       author = {Detrez, N;Miura, Y;Seifert, E;Theisen-Kunde, D and Brinkmann, R},
       title = {Heating and optoacoustic temperature determination of cell cultures},
       publisher = {SPIE},
       volume = {11079},
       series = {European Conferences on Biomedical Optics},
    booktitle =    {Proc. SPIE 11079, Medical Laser Applications
    and Laser-Tissue Interactions IX},
       url = {https://doi.org/10.1117/12.2527024},
    keywords = {Laser, Noninvasive thermometry, hyperthermia, temperature measurement, photoacoustics}, optoacoustics,
       year = {2019},
       type = {Conference Proceeding}
    }
    
  • Bliedtner,K; Seifert, E and Brinkmann,R: Dosimetry for microsecond selective laser trabeculoplasty. in Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX, no. 11079, 2019
    BibTeX Link
    @inproceedings{Bliedtner2019,
       author = {Bliedtner,K; Seifert, E and Brinkmann,R},
       title = {Dosimetry for microsecond selective laser trabeculoplasty},
       volume = {11079},
       DOI = {10.1117/12.2526987},
       year = {2019},
    keywords = {Ophthalmology, ophthalmic optics and devices, selective laser trabeculoplasty, micro bubble detection},
    booktitle =    {Proc. SPIE 11079, Medical Laser Applications
    and Laser-Tissue Interactions IX},
       type = {Conference proceedings}
    }
    

2018

  • Seifert, E; Tode, J; Pielen, A; Theisen-Kunde, D; Framme, C; Roider, J; Miura, Y; Birngruber, R and Brinkmann, R: Selective retina therapy: toward an optically controlled automatic dosing. J Biomed Opt 23(11), pp. 1-12, 2018
    BibTeX Link
    @article{seifert2018,
       author = {Seifert, E; Tode, J; Pielen, A; Theisen-Kunde, D; Framme, C; Roider, J; Miura, Y; Birngruber, R and Brinkmann, R},
       title = {Selective retina therapy: toward an optically controlled automatic dosing},
       journal = {J Biomed Opt} {23(11)},
       
       pages = {1-12},
       ISSN = {1560-2281 (Electronic)
    1083-3668 (Linking)},
       DOI = {10.1117/1.JBO.23.11.115002},   
    keywords = {algorithm, lasers in medicine, ophthalmology, retinal pigment epithelium, selective retina therapy, selectivity}
       year = {2018},
       type = {Journal Article}
    }
    

2017

  • Bliedtner, K; Seifert, E; Brinkmann, R and Amelink A: Real Time Speckle Monitoring to Control Retinal Photocoagulation. in Proc. SPIE 10413, pp. 1041308-1-7, 2017
    BibTeX Link
    @inproceedings{Bliedtner2017,
       author = {Bliedtner, K; Seifert, E; Brinkmann, R and  Amelink A},
       title = {Real Time Speckle Monitoring to Control Retinal Photocoagulation},
       booktitle = {Proc. SPIE} {10413},
       
       pages = {1041308-1-7},
      
    url = { https://doi.org/10.1117/12.2287815},
    Year = { 2017}

2016

  • Bliedtner, Katharina and Seifert, Eric and Stockmann, Leoni and Effe, Lisa and Brinkmann, Ralf: Towards real time speckle controlled retinal photocoagulation. no. 9693, pp. 96931A-96931A-6, 2016
    BibTeX Link
    @inproceedings{Bliedtner2016,
       author = {Bliedtner, Katharina and Seifert, Eric and Stockmann, Leoni and Effe, Lisa and Brinkmann, Ralf},
       title = {Towards real time speckle controlled retinal photocoagulation},
       volume = {9693},
       pages = {96931A-96931A-6},
       note = {10.1117/12.2212703},
       abstract = {Photocoagulation is a laser treatment widely used for the therapy of several retinal diseases. Intra- and inter-individual variations of the ocular transmission, light scattering and the retinal absorption makes it impossible to achieve a uniform effective exposure and hence a uniform damage throughout the therapy. A real-time monitoring and control of the induced damage is highly requested. Here, an approach to realize a real time optical feedback using dynamic speckle analysis is presented. A 532 nm continuous wave Nd:YAG laser is used for coagulation. During coagulation, speckle dynamics are monitored by a coherent object illumination using a 633nm HeNe laser and analyzed by a CMOS camera with a frame rate up to 1 kHz. It is obvious that a control system needs to determine whether the desired damage is achieved to shut down the system in a fraction of the exposure time. Here we use a fast and simple adaption of the generalized difference algorithm to analyze the speckle movements. This algorithm runs on a FPGA and is able to calculate a feedback value which is correlated to the thermal and coagulation induced tissue motion and thus the achieved damage. For different spot sizes (50-200 μm) and different exposure times (50-500 ms) the algorithm shows the ability to discriminate between different categories of retinal pigment epithelial damage ex-vivo in enucleated porcine eyes. Furthermore in-vivo experiments in rabbits show the ability of the system to determine tissue changes in living tissue during coagulation.},
       url = {http://dx.doi.org/10.1117/12.2212703},
       type = {Conference Proceedings},
    year = { 2016}
    }
    
  • Kang, S. and Park, Y. G. and Kim, J. R. and Seifert, E. and Theisen-Kunde, D and Brinkman, R and Roh, Y. J.: Selective Retina Therapy in Patients With Chronic Central Serous Chorioretinopathy: A Pilot Study. Medicine (Baltimore), no. 95, pp. e2524, 2016
    BibTeX Link
    @article{Kang1016,
       author = {Kang, S. and Park, Y. G. and Kim, J. R. and Seifert, E. and Theisen-Kunde, D and Brinkman, R and Roh, Y. J.},
       title = {Selective Retina Therapy in Patients With Chronic Central Serous Chorioretinopathy: A Pilot Study},
       journal = {Medicine (Baltimore)},
       volume = {95},
       number = {3},
       pages = {e2524},
       note = {1536-5964
    Kang, Seungbum
    Park, Young Gun
    Kim, Jae Ryun
    Seifert, Eric
    Dirk, Theisen-Kunde
    Ralf, Brinkmann
    Roh, Young Jung
    Journal Article
    United States
    Medicine (Baltimore). 2016 Jan;95(3):e2524. doi: 10.1097/MD.0000000000002524.},
       abstract = {We evaluated visual outcomes, changes of maximum macular thickness (MMT) and subretinal fluid (SRF), and safety in patients with chronic central serous chorioretinopathy (CSC) after treatment with selective retina therapy (SRT). Retrospective cohort study of patients with chronic CSC presenting to a university-based hospital from January 2014 through January 2015 was conducted. A total of 12 eyes of 12 patients with chronic CSC lasting for at least 3 months was recruited. The follow-up period ranged from 3 to 12 months. Following evaluation of test spots at temporal arcades, SRT (Q-switched neodymium-doped yttrium lithium fluoride [Nd:YLF] laser; wavelength, 527 nm, pulse duration, 1.7 microsececond) was applied to the surrounding areas of leakage observed on fluorescein angiogram and/or pigment epithelial detachment (PED). Changes in best-correct visual acuity (BCVA), MMT, and SRF and macular sensitivity (MS) by microperimetry (MP) were evaluated. Eyes received treatment in a mean of 3.83 spots at the pulse energy of 65 to 90 muJ. Mean BCVA (logMAR) improved from 0.23 +/- 0.12 at baseline to 0.14 +/- 0.13 at 3 months. MMT decreased from 341.4 +/- 85.5 mum at baseline to 236.0 +/- 57.9 mum at 3 months. SRF completely resolved in 75% (9 eyes) at 3 months. Large PEDs (2 eyes) were flattened at 3 months. Retreatment was performed in 4 eyes. MP showed no evidence of scotoma around SRT-treated lesions. SRT treatment targeting the surrounding area of leakage point showed favorable visual and structural outcomes in chronic CSC patients without the risk of scotoma.},
       ISSN = {0025-7974},
       DOI = {10.1097/md.0000000000002524},
       year = {2016},
       type = {Journal Article}
    }
    
  • Park, Y. G. and Kim, J. R. and Kang, S. and Seifert, E. and Theisen-Kunde, D. and Brinkmann, R. and Roh, Y. J.: Safety and efficacy of selective retina therapy (SRT) for the treatment of diabetic macular edema in Korean patients. Graefes Arch Clin Exp Ophthalmol, 2016
    BibTeX Link
    @article{Park2016,
       author = {Park, Y. G. and Kim, J. R. and Kang, S. and Seifert, E. and Theisen-Kunde, D. and Brinkmann, R. and Roh, Y. J.},
       title = {Safety and efficacy of selective retina therapy (SRT) for the treatment of diabetic macular edema in Korean patients},
       journal = {Graefes Arch Clin Exp Ophthalmol},
       note = {1435-702x
    Park, Young Gun
    Kim, Jae Ryun
    Kang, Seungbum
    Seifert, Eric
    Theisen-Kunde, Dirk
    Brinkmann, Ralf
    Roh, Young-Jung
    Journal article
    Graefes Arch Clin Exp Ophthalmol. 2016 Jan 23.},
       abstract = {PURPOSE: Selective retina therapy (SRT) stimulates retinal pigment epithelium (RPE) cell migration and proliferation into irradiated areas. The objective of this study was to evaluate the efficacy and safety of SRT in Korean patients with clinically significant diabetic macular edema (DME). METHODS: Prospective non-randomized interventional case series study. Twenty-three eyes of 21 patients with clinically significant DME were treated with SRT and followed for 6 months. Patients underwent an evaluation of best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study (ETDRS) letters. Microperimetry was employed to measure macular sensitivity within the central 10 degrees field, and the central macular thickness (CMT) and maximum macular thickness (MMT) were measured. RESULTS: An improvement in BCVA of one to two ETDRS lines was observed in 41.2 % of patients and an improvement of greater than two lines in 29.4 %. Although there was no significant change in CMT (P > 0.05), MMT decreased from 465.8 +/- 87.4 mum to 434.3 +/- 83.9 mum (P = 0.006), and mean macular sensitivity increased from 20.8 +/- 3.4dB to 22.5 +/- 3.5dB (P = 0.02). CONCLUSIONS: The gains in BCVA and improvement in macular sensitivity demonstrated that SRT may be used as an effective and safe treatment modality in Korean patients with clinically significant DME.},
       keywords = {Diabetic macular edema
    Dosimetry
    Microperimetry
    Retinal pigment epithelium
    Selective retina therapy},
       ISSN = {0721-832x},
       DOI = {10.1007/s00417-015-3262-1},
       year = {2016},
       type = {Journal Article}
    }
    

2013

  • Bliedtner, Kathrin and Seifert, Eric and Brinkmann, Ralf: emperature induced tissue deformation monitored by dynamic speckle interferometry. in Studierendentagung, Universität zu Lübeck, 2013
    BibTeX Link
    @inproceedings{Bliedtner2013,
       author = {Bliedtner, Kathrin and Seifert, Eric and Brinkmann, Ralf},
       title = {Temperature induced tissue deformation monitored
    by dynamic speckle interferometry},
       booktitle = {Studierendentagung},
       publisher = {Universität zu Lübeck},
       type = {Conference Proceedings},
    year = { 2013}
    url = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.714.8862&rep=rep1&type=pdf}
    }
    
  • Seifert, Eric and Roh, Young-Jung and Fritz, Andreas and Park, Young Gun and Kang, Seungbum and Theisen-Kunde, Dirk and Brinkmann, Ralf: Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model. no. 8803, pp. 880303-880303-6, 2013
    BibTeX Link
    @inproceedings{Seifert2013,
       author = {Seifert, Eric and Roh, Young-Jung and Fritz, Andreas and Park, Young Gun and Kang, Seungbum and Theisen-Kunde, Dirk and Brinkmann, Ralf},
       title = {Automatic irradiation control by an optical feedback technique for selective retina treatment (SRT) in a rabbit model},
       volume = {8803},
       pages = {880303-880303-6},
    year = {2013},
       note = {10.1117/12.2033560},
       abstract = {Selective Retina Therapy (SRT) targets the Retinal Pigment Epithelium (RPE) without effecting neighboring layers as the photoreceptors or the choroid. SRT related RPE defects are ophthalmoscopically invisible. Owing to this invisibility and the variation of the threshold radiant exposure for RPE damage the treating physician does not know whether the treatment was successful or not. Thus measurement techniques enabling a correct dosing are a demanded element in SRT devices. The acquired signal can be used for monitoring or automatic irradiation control. Existing monitoring techniques are based on the detection of micro-bubbles. These bubbles are the origin of RPE cell damage for pulse durations in the ns and μs time regime 5μs. The detection can be performed by optical or acoustical approaches. Monitoring based on an acoustical approach has already been used to study the beneficial effects of SRT on diabetic macula edema and central serous retinopathy. We have developed a first real time feedback technique able to detect micro-bubble induced characteristics in the backscattered laser light fast enough to cease the laser irradiation within a burst. Therefore the laser energy within a burst of at most 30 pulses is increased linearly with every pulse. The laser irradiation is ceased as soon as micro-bubbles are detected. With this automatic approach it was possible to observe invisible lesions, an intact photoreceptor layer and a reconstruction of the RPE within one week.},
       url = {http://dx.doi.org/10.1117/12.2033560},
       type = {Conference Proceedings}
    }