Publikationen

2020

  • Matkivsky, V;Moiseev, A;Shilyagin, P;Rodionov, A;Spahr, H;Pfäffle, C;Hüttmann, G;Hillmann, D and Gelikonov, G: Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function. Journal of Biophotonics, no. 13(10), pp. e202000112, 2020
    BibTeX Link
    @article{Matkivsky2020,
       author = {Matkivsky, V;Moiseev, A;Shilyagin, P;Rodionov, A;Spahr, H;Pfäffle, C;Hüttmann, G;Hillmann, D and Gelikonov, G},
       title = {Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function},
       journal = {Journal of Biophotonics},
       volume = {13(10)},
       pages = {e202000112},
       ISSN = {1864-063X},
       DOI = {10.1002/jbio.202000112},
       year = {2020},
       type = {Journal Article}
    }
    

2019

  • Pfäffle, C;Spahr, H;Kutzner, L;Burhan, S;Hilge, F;Miura, Y;Hüttmann, G and Hillmann, D: Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina. Optics Letters 44(23), pp. 5671-5674, 2019
    BibTeX Link
    @article{Pfäffle2019,
       author = {Pfäffle, C;Spahr, H;Kutzner, L;Burhan, S;Hilge, F;Miura, Y;Hüttmann, G and Hillmann, D},
       title = {Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina},
       journal = {Optics Letters 44(23)},
     
       pages = {5671-5674},
       DOI = {10.1364/OL.44.005671},
       
       year = {2019},
       type = {Journal Article}
    }
    
  • Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck: Phase-sensitive interferometry of decorrelated speckle patterns. Scientific Reports, no. 9(1), pp. 11748, 2019
    BibTeX Link
    @article{Spahr 2019,
       author = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck},
       title = {Phase-sensitive interferometry of decorrelated speckle patterns},
       journal = {Scientific Reports},
       volume = {9(1)},
       
       pages = {11748},
       ISSN = {2045-2322},
      
       url = {https://doi.org/10.1038/s41598-019-47979-8},
       year = {2019},
       type = {Journal Article}
    }
    
  • Hillmann, Dierck;Pfäffle, Clara;Spahr, Hendrik;Sudkamp, Helge;Franke, Gesa and Hüttmann, Gereon: In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells. in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics, pp. 181-194, Springer International Publishing, Cham, 2019
    BibTeX Link
    @inbook{Hillmann2019,
       author = {Hillmann, Dierck;Pfäffle, Clara;Spahr, Hendrik;Sudkamp, Helge;Franke, Gesa and Hüttmann, Gereon},
       title = {In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells},
       booktitle = {High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics},
       editor = {Bille, Josef F.},
       publisher = {Springer International Publishing},
       address = {Cham},
       pages = {181-194},
       ISBN = {978-3-030-16638-0},
       
       url = {https://doi.org/10.1007/978-3-030-16638-0_8},
       year = {2019},
       type = {Book Section}
    }
    
  • Hillmann, D.;Pfaffle, C.;Spahr, H.;Burhan, S.;Kutzner, L.;Hilge, F. and Hüttmann, G.: Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations. Opt Lett 44 (15), pp. 3905-3908, 2019
    BibTeX Link Link
    @article{Hillmann2019,
       author = {Hillmann, D.;Pfaffle, C.;Spahr, H.;Burhan, S.;Kutzner, L.;Hilge, F. and Hüttmann, G.},
       title = {Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations},
       journal = {Opt Lett 44 (15)},
     
       pages = {3905-3908},
       ISSN = {1539-4794 (Electronic)
    0146-9592 (Linking)},
       DOI = {10.1364/OL.44.003905},
       url = {https://www.ncbi.nlm.nih.gov/pubmed/31368998},
       year = {2019},
       type = {Journal Article}
    }
    
  • Spahr, H; Pfäffle, C; Huettmann, G and Hillmann, D: Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion. Opt Lett 44(5), pp. 1315-1318, 2019
    BibTeX Link
    @article{Spahr2019,
       author = {Spahr, H; Pfäffle, C; Huettmann, G and Hillmann, D},
       title = { Artifacts in speckle tracking and multi-aperture
    Doppler OCT imaging of lateral motion},
       journal = { Opt Lett} {44(5)},
       pages = {1315-1318},
    URL = {https://doi.org/10.1364/OL.44.001315},
       year = {2019},
       type = {Journal Article}
    }
    

2018

  • Sudkamp, H; Hillmann, D; Koch, P;vom Endt, M; Spahr, H; Münst, M; Pfäffle, C; Birngruber, R and Hüttmann, G: Simple approach for aberration-corrected OCT imaging of the human retina. Opt Lett 43(17), pp. 4224, 2018
    BibTeX Link
    @article{Sudkamp2018a,
       author = {Sudkamp, H; Hillmann, D; Koch, P;vom Endt, M; Spahr, H; Münst, M; Pfäffle, C; Birngruber, R and Hüttmann, G},
       title = {Simple approach for aberration-corrected OCT imaging of the human retina},
       journal = {Opt Lett} {43(17)},
       
       pages = {4224},
       ISSN = {0146-9592
    1539-4794},
       DOI = {10.1364/ol.43.004224},
       year = {2018},
       type = {Journal Article},
       keyword = {Retome}
    }
    
  • Spahr, H; Pfäffle, C; Koch,C; Sudkamp, H; Hüttmann, G und Hillmann, D: Interferometric detection of 3D motion using computational subapertures in optical coherence tomography. Opt. Expr 15(26), pp. 18803-18816, OSA, 2018
    BibTeX Link
    @article{Spahr:18,
    author = { Spahr, H; Pfäffle, C; Koch,C; Sudkamp, H; Hüttmann, G und Hillmann, D},
    journal = {Opt Expr} {15(26)},
    keywords = {Funktion, Fullfield},
    
    pages = {18803--18816},
    publisher = {OSA},
    title = {Interferometric detection of 3D motion using computational subapertures in optical coherence tomography},
    
    
    year = {2018},
    url = {https://doi.org/10.1364/OE.26.018803},
    
    abstract = {Doppler optical coherence tomography (OCT) quantifies axial motion with high precision, whereas lateral motion cannot be detected by a mere evaluation of phase changes. This problem was solved by the introduction of three-beam Doppler OCT, which, however, entails a high experimental effort. Here, we present the numerical analogue to this experimental approach. Phase-stable complex-valued OCT datasets, recorded with full-field swept-source OCT, are filtered in the Fourier domain to limit imaging to different computational subapertures. These are used to calculate all three components of the motion vector with interferometric precision. As known from conventional Doppler OCT for axial motion only, the achievable accuracy exceeds the actual imaging resolution by orders of magnitude in all three dimensions. The feasibility of this method is first demonstrated by quantifying micro-rotation of a scattering sample. Subsequently, a potential application is explored by recording the 3D motion vector field of tissue during laser photocoagulation in ex-vivo porcine retina.},
    }
    
    

2017

  • Pfäffle, Clara and Spahr, Hendrik and Hillmann, Dierck and Sudkamp, Helge and Franke, Gesa and Koch, Peter and Hüttmann, Gereon: Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited]. Biomedical Optics Express, no. 8, pp. 1499-1511, 2017
    BibTeX Link
    @article{Pfäffle2017,
       author = {Pfäffle, Clara and Spahr, Hendrik and Hillmann, Dierck and Sudkamp, Helge and Franke, Gesa and Koch, Peter and Hüttmann, Gereon},
       title = {Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited]},
       journal = {Biomedical Optics Express},
       volume = {8},
       number = {3},
       pages = {1499-1511},
       keywords = {Image reconstruction-restoration
    Optical coherence tomography},
       url = {http://www.osapublishing.org/boe/abstract.cfm?URI=boe-8-3-1499},
       year = {2017},
       type = {Journal Article}
    }
    

2016

  • Hillmann, Dierck and Spahr, Hendrik and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon: In vivo optical imaging of physiological responses to photostimulation in human photoreceptors. PNAS Early Edition, pp. 1-6, 2016
    BibTeX Link
    @article{Hillmann2016,
       author = {Hillmann, Dierck and Spahr, Hendrik and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon},
       title = {In vivo optical imaging of physiological responses to photostimulation in human photoreceptors},
       journal = {PNAS Early Edition},
       pages = {1-6},
       abstract = {Noninvasive functional imaging of molecular and cellular processes of vision may have immense impact on research and clinical diagnostics. Although suitable intrinsic optical signals (IOSs) have been observed ex vivo and in immobilized animals in vivo, detecting IOSs of photoreceptor activity in living humans was cumbersome and time consuming. Here, we observed clear spatially and temporally resolved changes in the optical path length of the photoreceptor outer segment as a response to an optical stimulus in the living human eye. To witness these changes, we evaluated phase data obtained with a parallelized and computationally aberration-corrected optical coherence tomography system. The noninvasive detection of optical path length changes shows neuronal photoreceptor activity of single cones in living human retina, and therefore, it may provide diagnostic options in ophthalmology and neurology and could provide insights into visual phototransduction in humans.},
       url = {http://www.pnas.org/content/early/2016/10/10/1606428113.abstract},
       year = {2016},
       type = {Journal Article}
    }
    
  • Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon: Imaging vascular dynamics in human retina using full-field swept-source optical coherence tomography (Conference Presentation). no. 9697, pp. 96970E-96970E-1, 2016
    BibTeX Link
    @inproceedings{Spahr2016,
       author = {Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon},
       title = {Imaging vascular dynamics in human retina using full-field swept-source optical coherence tomography (Conference Presentation)},
       volume = {9697},
       pages = {96970E-96970E-1},
       note = {10.1117/12.2214303},
       abstract = {We demonstrate a new non-invasive method to assess the functional condition of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. Motion of retinal tissue, that is induced by expansion of the vessels therein, is measured with an accuracy of about 10 nm. The pulse shape of arterial and venous pulsation, their temporal delay as well as the frequency dependent pulse propagation through the capillary bed are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.},
       url = {http://dx.doi.org/10.1117/12.2214303},
       type = {Conference Proceedings},
    year = { 2016}
    }
    
  • Spahr, H. and Hillmann, D. and Hain, C. and Pfäffle, C. and Sudkamp, H. and Franke, G. and Koch, P. and Hüttmann, G.: Darstellung von Blutfluss und Pulsation in retinalen Gefäßen mit Full-Field-Swept-Source-OCT. Klin Monatsbl Augenheilkd, no. 233, pp. 1324-1330, 2016
    BibTeX Link
    @article{Spahr2016,
       author = {Spahr, H. and Hillmann, D. and Hain, C. and Pfäffle, C. and Sudkamp, H. and Franke, G. and Koch, P. and Hüttmann, G.},
       title = {Darstellung von Blutfluss und Pulsation in retinalen Gefäßen mit Full-Field-Swept-Source-OCT},
       journal = {Klin Monatsbl Augenheilkd},
       volume = {233},
       number = {12},
       pages = {1324-1330},
       ISSN = {0023-2165},
       DOI = {10.1055/s-0042-120279},
       year = {2016},
       type = {Journal Article}
    }
    
  • Hillmann, Dierck and Spahr, Hendrik and Hain, Carola and Sudkamp, Helge and Franke, Gesa and Pfäffle, Clara and Winter, Christian and Hüttmann, Gereon: Aberration-free volumetric high-speed imaging of in vivo retina. Scientific Reports, no. 6, pp. 1-11, 2016
    BibTeX Link
    @article{Hillmann2016,
       author = {Hillmann, Dierck and Spahr, Hendrik and Hain, Carola and Sudkamp, Helge and Franke, Gesa and Pfäffle, Clara and Winter, Christian and Hüttmann, Gereon},
       title = {Aberration-free volumetric high-speed imaging of in vivo retina},
       journal = {Scientific Reports},
       volume = {6},
       pages = {1-11},
       url = {http://dx.doi.org/10.1038/srep35209},
       year = {2016},
       type = {Journal Article}
    }
    

2015

  • Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon: Imaging pulse wave propagation in human retinal vessels using full-field swept-source optical coherence tomography. Optics Letters, no. 40, pp. 4771-4774, 2015
    BibTeX Link Link
    @article{Spahr2015,
       author = {Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon},
       title = {Imaging pulse wave propagation in human retinal vessels using full-field swept-source optical coherence tomography},
       journal = {Optics Letters},
       volume = {40},
       number = {20},
       pages = {4771-4774},
       abstract = {We demonstrate a new noninvasive method to assess biomechanical properties of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. The motion of retinal tissue that is induced by expansion of the vessels therein is measured with an accuracy of about 10 nm. The pulse shapes of arterial and venous pulsations, their temporal delays, as well as the frequency-dependent pulse propagation through the capillary bed, are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.},
       keywords = {Optical coherence tomography
    Ophthalmology
    Time-resolved imaging
    Functional monitoring and imaging},
       DOI = {10.1364/OL.40.004771},
       url = {http://ol.osa.org/abstract.cfm?URI=ol-40-20-4771},
       year = {2015},
       type = {Journal Article}
    }