2012
I.
Rohde,
R.
Brinkmann, and
D.
Theisen-Kunde,
Temporally stretched Q-switched pulses in the 2 µm spectral range, Laser Physics Letters , vol. 9, no. 11, pp. 808-813, 2012.
Temporally stretched Q-switched pulses in the 2 µm spectral range, Laser Physics Letters , vol. 9, no. 11, pp. 808-813, 2012.
U.
Gehlsen,
A.
Oetke,
M.
Szaszak,
N.
Koop,
F.
Paulsen,
A.
Gebert,
G.
Huettmann, and
P.
Steven,
Two-photon fluorescence lifetime imaging monitors metabolic changes during wound healing of corneal epithelial cells in vitro, Graefes Arch Clin Exp Ophthalmol , vol. 6, pp. 6, 2012.
Two-photon fluorescence lifetime imaging monitors metabolic changes during wound healing of corneal epithelial cells in vitro, Graefes Arch Clin Exp Ophthalmol , vol. 6, pp. 6, 2012.
C.
Unglert,
W.
Warger,
J.
Hostens,
E.
Namati,
B.
Bouma, and
G.
Tearney,
Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography, Journal of Biomedical Optics , vol. 17, no. 12, 2012.
Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography, Journal of Biomedical Optics , vol. 17, no. 12, 2012.
DOI: | Artn 126015 Doi 10.1117/1.Jbo.17.12.126015 |
File: | WOS:000314504400023 |
Bibtex: | @article{Unglert2012, author = {Unglert, C. I. and Warger, W. C. and Hostens, J. and Namati, E. and Birngruber, R. and Bouma, B. E. and Tearney, G. J.}, title = {Validation of two-dimensional and three-dimensional measurements of subpleural alveolar size parameters by optical coherence tomography}, journal = {Journal of Biomedical Optics}, volume = {17}, number = {12}, note = {083ZB Times Cited:3 Cited References Count:23}, abstract = {Optical coherence tomography (OCT) has been increasingly used for imaging pulmonary alveoli. Only a few studies, however, have quantified individual alveolar areas, and the validity of alveolar volumes represented within OCT images has not been shown. To validate quantitative measurements of alveoli from OCT images, we compared the cross-sectional area, perimeter, volume, and surface area of matched subpleural alveoli from microcomputed tomography (micro-CT) and OCT images of fixed air-filled swine samples. The relative change in size between different alveoli was extremely well correlated (r > 0.9, P < 0.0001), but OCT images underestimated absolute sizes compared to micro-CT by 27% (area), 7% (perimeter), 46% (volume), and 25% (surface area) on average. We hypothesized that the differences resulted from refraction at the tissue-air interfaces and developed a ray-tracing model that approximates the reconstructed alveolar size within OCT images. Using this model and OCT measurements of the refractive index for lung tissue (1.41 for fresh, 1.53 for fixed), we derived equations to obtain absolute size measurements of superellipse and circular alveoli with the use of predictive correction factors. These methods and results should enable the quantification of alveolar sizes from OCT images in vivo. (c) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.12.126015]}, keywords = {alveolar structure alveolar volume ray-tracing optical coherence tomography refractive-index tissue}, ISSN = {1083-3668}, DOI = {Artn 126015 Doi 10.1117/1.Jbo.17.12.126015}, url = {<Go to ISI>://WOS:000314504400023}, year = {2012}, type = {Journal Article} } |
F.
Treumer,
A.
Klettner,
J.
Baltz,
A.
Hussain,
Y.
Miura,
R.
Brinkmann,
J.
Roider, and
J.
Hillenkamp,
Vectorial release of matrix metalloproteinases (MMPs) from porcine RPE-choroid explants following selective retina therapy (SRT): towards slowing the macular ageing process, Exp Eye Res , vol. 97, no. 1, pp. 63-72, 2012.
Vectorial release of matrix metalloproteinases (MMPs) from porcine RPE-choroid explants following selective retina therapy (SRT): towards slowing the macular ageing process, Exp Eye Res , vol. 97, no. 1, pp. 63-72, 2012.
DOI: | 10.1016/j.exer.2012.02.011 |
Bibtex: | @article{Treumer2012, author = {Treumer, F. and Klettner, A. and Baltz, J. and Hussain, A. A. and Miura, Y. and Brinkmann, R. and Roider, J. and Hillenkamp, J.}, title = {Vectorial release of matrix metalloproteinases (MMPs) from porcine RPE-choroid explants following selective retina therapy (SRT): towards slowing the macular ageing process}, journal = {Exp Eye Res}, volume = {97}, number = {1}, pages = {63-72}, note = {1096-0007 Treumer, F Klettner, A Baltz, J Hussain, A A Miura, Y Brinkmann, R Roider, J Hillenkamp, J Journal Article England Exp Eye Res. 2012 Apr;97(1):63-72. doi: 10.1016/j.exer.2012.02.011. Epub 2012 Feb 22.}, abstract = {The purpose of this study was to investigate release of matrix metalloproteinases (MMP) 2 and 9 during retinal pigment epithelium (RPE) wound healing after Selective Retina Therapy (SRT) with laser energy levels below and above the threshold of RPE cell death. Following exposure to SRT using a prototype pulsed Nd:YLF laser with energies of 80-180 mJ/cm(2) fresh porcine RPE-monolayers with Bruch's membrane and choroid were cultured in modified Ussing chambers which separate the apical (RPE-facing) and basal (choroid facing) sides of the RPE monolayer. Threshold energy for RPE cell death and wound healing were determined with calcein-AM viability test. Inactive and active forms of MMP 2 and 9 were quantified within tissue samples and in the culture medium of the apical and basal compartments of the Ussing chamber using gelatine zymography. Laser energies of 160-180 mJ/cm(2) resulted in cell death within 1 h while 120-140 mJ/cm(2) resulted in delayed death of exposed RPE cells. All cells survived 80 and 100 mJ/cm(2). Laser spots healed within 6 days after SRT accompanied by a transient vectorial increase of MMPs. SRT with 180 mJ/cm(2) increased active MMP 2 by 1.9 (p < 0.05) and 1.6 (p < 0.05) fold in tissue and basal compartments, respectively, without alterations in the apical compartment. Pro-MMP 2 levels were also significantly increased in all compartments (p < 0.05). Release of MMP 9 was not altered. Laser energy below the threshold of RPE cell death did not alter the release of MMP 2 or 9. The findings suggest that the release of active MMP 2 on the basal side of the RPE during wound healing following SRT may address age-related pathological changes of Bruch's membrane with a potential to slow degenerative macular ageing processes before irreversible functional loss has occurred.}, keywords = {Animals Cell Death Cell Survival Choroid/*enzymology/pathology Diffusion Chambers, Culture Fluoresceins/metabolism *Laser Therapy Lasers, Solid-State Macular Degeneration/enzymology/pathology/*surgery Matrix Metalloproteinase 2/*metabolism Matrix Metalloproteinase 9/*metabolism Organ Culture Techniques Retinal Pigment Epithelium/*enzymology/pathology Sensory Thresholds Swine Wound Healing/*physiology}, ISSN = {0014-4835}, DOI = {10.1016/j.exer.2012.02.011}, year = {2012}, type = {Journal Article} } |
F.
Rudnitzki,
M.
Bever,
R.
Rahmanzadeh,
K.
Brieger,
E.
Endl, and
J.
Groll,
Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction, J Biomed Opt , vol. 17, no. 5, pp. 058003, 2012.
Bleaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction, J Biomed Opt , vol. 17, no. 5, pp. 058003, 2012.
DOI: | 10.1117/1.JBO.17.5.058003 |
Bibtex: | @Article{pmid22612150, Author="Rudnitzki, F. and Bever, M. and Rahmanzadeh, R. and Brieger, K. and Endl, E. and Groll, J. and Huttmann, G. ", Title="{{B}leaching of plasmon-resonance absorption of gold nanorods decreases efficiency of cell destruction}", Journal="J Biomed Opt", Year="2012", Volume="17", Number="5", Pages="058003", Month="May" } |
2011
C.
Eigenwillig,
T.
Klein,
W.
Wieser,
B.
Biedermann, and
R.
Huber,
Wavelength swept amplified spontaneous emission source for high speed retinal optical coherence tomography at 1060 nm, Journal of Biophotonics , vol. 4, no. 7-8, pp. 552-558, Nov. 2011.
Wavelength swept amplified spontaneous emission source for high speed retinal optical coherence tomography at 1060 nm, Journal of Biophotonics , vol. 4, no. 7-8, pp. 552-558, Nov. 2011.
DOI: | 10.1002/jbio.201000104 |
Bibtex: | @article{https://doi.org/10.1002/jbio.201000104, author = {Eigenwillig, Christoph M. and Klein, Thomas and Wieser, Wolfgang and Biedermann, Benjamin R. and Huber, Robert}, title = {Wavelength swept amplified spontaneous emission source for high speed retinal optical coherence tomography at 1060 nm}, journal = {Journal of Biophotonics}, volume = {4}, number = {7-8}, pages = {552-558}, keywords = {optical coherence tomography, tunable lasers, optical frequency domain imaging, ophthalmology}, doi = {https://doi.org/10.1002/jbio.201000104}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201000104}, eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbio.201000104}, abstract = {Abstract The wavelength swept amplified spontaneous emission (ASE) source presented in this paper is an alternative approach to realize a light source for high speed swept source optical coherence tomography (OCT). ASE alternately passes a cascade of different optical gain elements and tunable optical bandpass filters. In this work we show for the first time a wavelength swept ASE source in the 1060 nm wavelength range, enabling high speed retinal OCT imaging. We demonstrate ultra-rapid retinal OCT at a line rate of 170 kHz, a record sweep rate at 1060 nm of 340 kHz with 70 nm full sweep width, enabling an axial resolution of 11 μm. Two different implementations of the source are characterized and compared to each other. The last gain element is either a semiconductor optical amplifier or an Ytterbium-doped fibre amplifier enabling high average output power of >40 mW. Various biophotonic imaging examples provide a wide range of quality benchmarks achievable with such sources. (© 2011 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim)}, year = {2011} } |
D.
Adler,
W.
Wieser,
F.
Trepanier,
J.
Schmitt, and
R.
Huber,
Extended coherence length Fourier domain mode locked lasers at 1310 nm, Opt. Express , vol. 19, no. 21, pp. 20930--20939, Oct. 2011. Optica Publishing Group.
Extended coherence length Fourier domain mode locked lasers at 1310 nm, Opt. Express , vol. 19, no. 21, pp. 20930--20939, Oct. 2011. Optica Publishing Group.
DOI: | 10.1364/OE.19.020930 |
Bibtex: | @article{Adler:11, author = {Desmond C. Adler and Wolfgang Wieser and Francois Trepanier and Joseph M. Schmitt and Robert A. Huber}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Medical optics and biotechnology; Dispersion compensation devices ; Fiber Bragg gratings ; Laser modes; Laser sources; Mode locking; Optical delay lines; Swept lasers; Tunable lasers}, number = {21}, pages = {20930--20939}, publisher = {Optica Publishing Group}, title = {Extended coherence length Fourier domain mode locked lasers at 1310 nm}, volume = {19}, month = {Oct}, year = {2011}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-19-21-20930}, doi = {10.1364/OE.19.020930}, abstract = {Fourier domain mode locked (FDML) lasers are excellent tunable laser sources for frequency domain optical coherence tomography (FD-OCT) systems due to their combination of high sweep rates, large tuning ranges, and high output powers. However, conventional FDML lasers provide coherence lengths of only 4--10 mm, limiting their use in demanding applications such as intravascular OCT where coherence lengths of \>20 mm are required for optimal imaging of large blood vessels. Furthermore, like most swept lasers, conventional FDML lasers produce only one useable sweep direction per tunable filter drive cycle, halving the effective sweep rate of the laser compared to the filter drive frequency. Here, we demonstrate a new class of FDML laser incorporating broadband dispersion compensation near 1310 nm. Elimination of chromatic dispersion in the FDML cavity results in the generation of forward (short to long wavelength) and backward (long to short wavelength) sweeps with substantially identical properties and coherence lengths of \>21 mm. This advance enables long-range, high-speed FD-OCT imaging without the need for optical buffering stages, significantly reducing laser cost and complexity.}, } |
R.
Brinkmann,
S.
Koinzer,
K.
Schlott,
L.
Ptaszynski,
M.
Bever,
A.
Baade,
Y.
Miura,
R.
Birngruber, and
J.
Roider,
Realtime temperature determination during retinal photocoagulation on patients, 09 2011.
Realtime temperature determination during retinal photocoagulation on patients, 09 2011.
Weblink: | https://doi.org/10.1117/12.875276 |
Bibtex: | @book{RN5360, author = {Brinkmann, Ralf;Koinzer, Stefan;Schlott, Kerstin;Ptaszynski, Lars;Bever, Marco;Baade, Alex;Miura, Yoko;Birngruber, Reginald and Roider, Johann}, title = {Realtime temperature determination during retinal photocoagulation on patients}, publisher = {SPIE}, volume = {7885}, series = {SPIE BiOS}, url = {https://doi.org/10.1117/12.875276}, year = {2011}, type = {Book} } |
T.
Klein,
W.
Wieser,
B.
Biedermann,
C.
Eigenwillig, and
R.
Huber,
FDML laser for megahertz retinal OCT imaging, in CLEO:2011 - Laser Applications to Photonic Applications , Optica Publishing Group, 062011. pp. CWB1.
FDML laser for megahertz retinal OCT imaging, in CLEO:2011 - Laser Applications to Photonic Applications , Optica Publishing Group, 062011. pp. CWB1.
DOI: | 10.1364/CLEO_SI.2011.CWB1 |
Bibtex: | @inproceedings{Klein:11, author = {Thomas Klein and Wolfgang Wieser and Benjamin R. Biedermann and Christoph M. Eigenwillig and Robert Huber}, booktitle = {CLEO:2011 - Laser Applications to Photonic Applications}, journal = {CLEO:2011 - Laser Applications to Photonic Applications}, keywords = {Optical coherence tomography; Lasers, tunable; Image quality; Imaging techniques; Laser modes; Medical imaging; Mode locking; Optical coherence tomography}, pages = {CWB1}, publisher = {Optica Publishing Group}, title = {FDML laser for megahertz retinal OCT imaging}, year = {2011}, url = {https://opg.optica.org/abstract.cfm?URI=CLEO_SI-2011-CWB1}, doi = {10.1364/CLEO_SI.2011.CWB1}, abstract = {A novel Fourier-domain mode locked (FDML) laser design is presented, yielding the highest wavelength sweep speed reported so far around 1050nm. This enables retinal imaging over a ~70{\textdegree} ultra-wide field of view.}, } |
C.
Blatter,
B.
Grajciar,
C.
Eigenwillig,
W.
Wieser,
B.
Biedermann,
R.
Huber, and
R.
Leitgeb,
High-speed functional OCT with self-reconstructive Bessel illumination at 1300 nm, in Optical Coherence Tomography and Coherence Techniques V , Rainer A. Leitgeb and Brett E. Bouma, Eds. SPIE, 062011. pp. 809104.
High-speed functional OCT with self-reconstructive Bessel illumination at 1300 nm, in Optical Coherence Tomography and Coherence Techniques V , Rainer A. Leitgeb and Brett E. Bouma, Eds. SPIE, 062011. pp. 809104.
DOI: | 10.1117/12.889669 |
Bibtex: | @inproceedings{10.1117/12.889669, author = {Cedric Blatter and Branislav Grajciar and Christoph M. Eigenwillig and Wolfgang Wieser and Benjamin R. Biedermann and Robert Huber and Rainer A. Leitgeb}, title = {{High-speed functional OCT with self-reconstructive Bessel illumination at 1300 nm}}, volume = {8091}, booktitle = {Optical Coherence Tomography and Coherence Techniques V}, editor = {Rainer A. Leitgeb and Brett E. Bouma}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {809104}, abstract = {We present a Bessel beam illumination FDOCT setup with FDML buffered swept source at 1300nm. An extended focus is achieved due to the Bessel beam that preserves its lateral extend over a large depth range. Decoupling the illumination from the Gaussian detection improves the sensitivity as compared to double passing the ring filter and enables dark field imaging. Dark field imaging is useful to avoid strong reflexes from the sample's surface that adversely affect the sensitivity due to the limited dynamic range of high-speed 8bit acquisition cards. Furthermore, Bessel beams exhibit a self-reconstruction property that allows imaging even behind obstacles such as hairs on skin. Densely sampled volumes of skin in-vivo with high lateral resolution are acquired at up to 440kHz A-Scan rate. In addition the possibility of contrasting capillaries with high sensitivity is shown, using inter-B-scan speckle variance analysis. High-speed imaging is of crucial importance for imaging small details since sample motion artifacts are reduced and high sampling can be maintained while increasing the B-Scan rate.}, keywords = {Extended focus, Bessel beam, Self-reconstructive illumination, Dark field imaging, Dermatology, Microcirculation imaging, FDML, Swept Source}, year = {2011}, doi = {10.1117/12.889669}, URL = {https://doi.org/10.1117/12.889669} } |
C.
Blatter,
B.
Grajciar,
C.
Eigenwillig,
W.
Wieser,
B.
Biedermann,
R.
Huber, and
R.
Leitgeb,
Extended focus high-speed swept source OCT with self-reconstructive illumination, Opt. Express , vol. 19, no. 13, pp. 12141-12155, 06 2011. Optica Publishing Group.
Extended focus high-speed swept source OCT with self-reconstructive illumination, Opt. Express , vol. 19, no. 13, pp. 12141-12155, 06 2011. Optica Publishing Group.
DOI: | 10.1364/OE.19.012141 |
Bibtex: | @article{Blatter:11, author = {Cedric Blatter and Branislav Grajciar and Christoph M. Eigenwillig and Wolfgang Wieser and Benjamin R. Biedermann and Robert Huber and Rainer A. Leitgeb}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Optical coherence tomography; Flow diagnostics; Coherence tomography ; Functional monitoring and imaging ; Functional imaging; Image quality; Imaging techniques; In vivo imaging; Optical imaging; Three dimensional imaging}, number = {13}, pages = {12141--12155}, publisher = {Optica Publishing Group}, title = {Extended focus high-speed swept source OCT with self-reconstructive illumination}, volume = {19}, month = {Jun}, year = {2011}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-19-13-12141}, doi = {10.1364/OE.19.012141}, abstract = {We present a Bessel beam illumination FDOCT setup using a FDML Swept Source at 1300nm with up to 440kHz A-scan rate, and discuss its advantages for structural and functional imaging of highly scattering samples. An extended focus is achieved due to the Bessel beam that preserves its lateral extend over a large depth range. Furthermore, Bessel beams exhibit a self-reconstruction property that allows imaging even behind obstacles such as hairs on skin. Decoupling the illumination from the Gaussian detection increases the global sensitivity and enables dark field imaging. Dark field imaging is useful to avoid strong reflexes from the sample surface that adversely affect the sensitivity due to the limited dynamic range of high speed 8bit acquisition cards. In addition the possibility of contrasting capillaries with high sensitivity is shown, using inter-B-scan speckle variance analysis. We demonstrate intrinsic advantages of the extended focus configuration, in particular the reduction of the phase decorrelation effect below vessels leading to improved axial vessel definition.}, } |
S.
Todor,
B.
Biedermann,
W.
Wieser,
R.
Huber, and
C.
Jirauschek,
Instantaneous lineshape analysis of Fourier domain mode-locked lasers, Opt. Express , vol. 19, no. 9, pp. 8802-8807, 04 2011. Optica Publishing Group.
Instantaneous lineshape analysis of Fourier domain mode-locked lasers, Opt. Express , vol. 19, no. 9, pp. 8802-8807, 04 2011. Optica Publishing Group.
DOI: | 10.1364/OE.19.008802 |
Bibtex: | @article{Todor:11, author = {Sebastian Todor and Benjamin Biedermann and Wolfgang Wieser and Robert Huber and Christian Jirauschek}, journal = {Opt. Express}, keywords = {Laser theory; Lasers, tunable; Optical coherence tomography; Linewidth; Laser sources; Mode locking; Power spectra; Semiconductor lasers; Swept lasers; Tunable lasers}, number = {9}, pages = {8802--8807}, publisher = {Optica Publishing Group}, title = {Instantaneous lineshape analysis of Fourier domain mode-locked lasers}, volume = {19}, month = {Apr}, year = {2011}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-19-9-8802}, doi = {10.1364/OE.19.008802}, abstract = {We present a theoretical and experimental analysis of the instantaneous lineshape of Fourier domain mode-locked (FDML) lasers, yielding good agreement. The simulations are performed employing a recently introduced model for FDML operation. Linewidths around 10 GHz are found, which is significantly below the sweep filter bandwidth. The effect of detuning between the sweep filter drive frequency and cavity roundtrip time is studied revealing features that cannot be resolved in the experiment, and shifting of the instantaneous power spectrum against the sweep filter center frequency is analyzed. We show that, in contrast to most other semiconductor based lasers, the instantaneous linewidth is governed neither by external noise sources nor by amplified spontaneous emission, but it is directly determined by the complex FDML dynamics.}, } |
C.
Blatter,
B.
Grajciar,
R.
Huber, and
R.
Leitgeb,
Structural and functional imaging with extended focus dark-field OCT at 1300nm, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 022011. pp. 78891D.
Structural and functional imaging with extended focus dark-field OCT at 1300nm, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 022011. pp. 78891D.
DOI: | 10.1117/12.875594 |
Bibtex: | @inproceedings{10.1117/12.875594, author = {Cedric Blatter and Branislav Grajciar and Robert Huber and Rainer A. Leitgeb}, title = {{Structural and functional imaging with extended focus dark-field OCT at 1300nm}}, volume = {7889}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV}, editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {78891D}, abstract = {We present an extended focus FDOCT setup with FDML swept source centered at 1310nm. The illumination, preserving its lateral extend over a large depth range thanks to the use of a Bessel beam, is decoupled from the Gaussian detection in order to increase the global sensitivity. The efficient spatial separation enables dark-field imaging. In-vivo measurements in the skin were performed to demonstrate the gain in lateral resolution while preserving the imaging depth. More, the calculation of the speckle variance between B-Scans allows a clear visualization of the microvasculature.}, keywords = {Extended focus, Dark Field imaging, Bessel beam, FDML Swept Source, dermatology, microvascularisation imaging}, year = {2011}, doi = {10.1117/12.875594}, URL = {https://doi.org/10.1117/12.875594} } |
T.
Klein,
W.
Wieser,
C.
Eigenwillig,
B.
Biedermann, and
R.
Huber,
Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser, Opt. Express , vol. 19, no. 4, pp. 3044--3062, 02 2011. Optica Publishing Group.
Megahertz OCT for ultrawide-field retinal imaging with a 1050 nm Fourier domain mode-locked laser, Opt. Express , vol. 19, no. 4, pp. 3044--3062, 02 2011. Optica Publishing Group.
DOI: | 10.1364/OE.19.003044 |
Bibtex: | @article{Klein:11, author = {Thomas Klein and Wolfgang Wieser and Christoph M. Eigenwillig and Benjamin R. Biedermann and Robert Huber}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Imaging systems; Ophthalmology; Optical coherence tomography; Retina scanning ; Fiber lasers; Image processing; Image quality; Mode locking; Ophthalmic imaging; Three dimensional imaging}, number = {4}, pages = {3044--3062}, publisher = {Optica Publishing Group}, title = {Megahertz OCT for ultrawide-field retinal imaging with a 1050nm Fourier domain mode-locked laser}, volume = {19}, month = {Feb}, year = {2011}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-19-4-3044}, doi = {10.1364/OE.19.003044}, abstract = {We demonstrate ultrahigh speed swept source retinal OCT imaging using a Fourier domain mode locked (FDML) laser. The laser uses a combination of a semiconductor optical amplifier and an ytterbium doped fiber amplifier to provide more than 50mW output power. The 1050nm FDML laser uses standard telecom fiber for the km long delay line instead of two orders of magnitude more expensive real single mode fiber. We investigate the influence of this ``oligo-mode'' fiber on the FDML laser performance. Two design configurations with 684,400 and 1,368,700 axial scans per second are investigated, 25x and 50x faster than current commercial instruments and more than 4x faster than previous single spot ophthalmic results. These high speeds enable the acquisition of densely sampled ultrawide-field data sets of the retina within a few seconds. Ultrawide-field data consisting of 1900 x 1900 A-scans with ~70{\textdegree} degrees angle of view are acquired within only 3 and 6 seconds using the different setups. Such OCT data sets, more than double as large as previously reported, are collapsed to a 4 megapixel high definition fundus image. We achieve good penetration into the choroid by hardware spectral shaping of the laser output. The axial resolution in tissue is 12{\textmu}m (684kHz) and 19{\textmu}m (1.37MHz). A series of new data processing and imaging extraction protocols, enabled by the ultrawide-field isotropic data sets, are presented. Dense isotropic sampling enables both, cross-sectional images along arbitrary coordinates and depth-resolved en-face fundus images. Additionally, we investigate how isotropic averaging compares to the averaging of cross-sections along the slow axis.}, } |
J.
Wang,
Z.
Li,
F.
Xue, and
Z.
Zhang,
Brownian diffusion of gold nanoparticles in an optical trap studied by fluorescence correlation spectroscopy, Laser Physics , vol. 21, no. 1, pp. 130-136, 2011.
Brownian diffusion of gold nanoparticles in an optical trap studied by fluorescence correlation spectroscopy, Laser Physics , vol. 21, no. 1, pp. 130-136, 2011.
R.
Rahmanzadeh,
J.
Celli,
I.
Rizvi,
J.
Gerdes, and
T.
Hasan,
The proliferation marker Ki-67 as novel molecular target for PDT, Photodiagnosis and Photodynamic Therapy , vol. 8, no. 2, pp. 129, 2011.
The proliferation marker Ki-67 as novel molecular target for PDT, Photodiagnosis and Photodynamic Therapy , vol. 8, no. 2, pp. 129, 2011.
DOI: | 10.1016/j.pdpdt.2011.03.025 |
Bibtex: | @article{Rahmanzadeh2011, author = {Rahmanzadeh, R. and Celli, J. and Rizvi, I. and Gerdes, J. and Hasan, T.}, title = {The proliferation marker Ki-67 as novel molecular target for PDT}, journal = {Photodiagnosis and Photodynamic Therapy}, volume = {8}, number = {2}, pages = {129}, DOI = {10.1016/j.pdpdt.2011.03.025}, year = {2011}, type = {Journal Article} } |
R.
Rahmanzadeh,
F.
Rudnitzki,
E.
Endl, and
T.
Hasan,
Targeted molecular effects through laser-irradiated nanoabsorbers, in Proc. SPIE , Newsrrom, SPIE, Eds. 2011.
Targeted molecular effects through laser-irradiated nanoabsorbers, in Proc. SPIE , Newsrrom, SPIE, Eds. 2011.
DOI: | 10.1117/2.1201102.003548 |
Bibtex: | @inproceedings{Hüttmann2011, author = {Hüttmann, Gereon and Rahmanzadeh, Ramtin and Rudnitzki, Florian and Endl, Elmar and Hasan, Tayyaba}, title = {Targeted molecular effects through laser-irradiated nanoabsorbers}, editor = {Newsrrom, SPIE}, DOI = {10.1117/2.1201102.003548}, type = {Conference Proceedings}, year = { 2011} } |
W.
Wieser, and
F.
Trepanier,
Extended coherence length \{Fourier} domain mode locked lasers at 1310\~{}\{nm}., Optics express , vol. 19, no. 21, pp. 20930--20939, 2011. OSA.
Extended coherence length \{Fourier} domain mode locked lasers at 1310\~{}\{nm}., Optics express , vol. 19, no. 21, pp. 20930--20939, 2011. OSA.
DOI: | 10.1364/OE.19.020930 |
File: | abstract.cfm |
Bibtex: | @article{HU_2011_Adler, author = {Adler, D C Desmond C and Wieser, Wolfgang and Trepanier, Francois and Schmitt, Joseph M and Huber, Robert A}, doi = {10.1364/OE.19.020930}, issn = {1094-4087}, journal = {Optics express}, number = {21}, pages = {20930--20939}, pmid = {21997102}, publisher = {OSA}, title = {{Extended coherence length \{Fourier\} domain mode locked lasers at 1310\~{}\{nm\}.}}, url = {http://www.opticsinfobase.org/abstract.cfm?uri=oe-19-21-20930}, volume = {19}, year = {2011} } |
S
Koinzer,
K
Schlott,
L
Ptaszynski, and
J
Roider,
Realtime temperature determination during retinal photocoagulation on patients., Proc SPIE , vol. 7885, pp. 78850R, 2011.
Realtime temperature determination during retinal photocoagulation on patients., Proc SPIE , vol. 7885, pp. 78850R, 2011.
File: | proceeding.aspx |
Bibtex: | @article{Brinkmann2011, author = {Brinkmann, R and Koinzer, S and Schlott, K and Ptaszynski, L and Bever, M and Baade, A and Miura, Y and Birngruber, R and Roider, J}, title = {Realtime temperature determination during retinal photocoagulation on patients.}, journal = {Proc SPIE}, volume = {7885}, pages = {78850R}, abstract = {Retinal photocoagulation is a long time established treatment for a variety of retinal diseases, most commonly applied for diabetic macular edema and diabetic retinopathy. The damage extent of the induced thermal coagulations depend on the temperature increase and the time of irradiation. So far, the induced temperature rise is unknown due to intraocular variations in light transmission and scattering and RPE/choroidal pigmentation, which can vary inter- and intraindividually by more than a factor of four. Thus in clinical practice, often stronger and deeper coagulations are applied than therapeutically needed, which lead to extended retinal damage and strong pain perception. The final goal of this project focuses on a dosimetry control, which automatically generates a desired temperature profile and thus coagulation strength for every individual coagulation spot, ideally unburden the ophthalmologist from any laser settings. In this paper we present the first realtime temperature measurements achieved on patients during retinal photocoagulation by means of an optoacoustic method, making use of the temperature dependence of the thermal expansion coefficient of retinal tissue. Therefore, nanosecond probe laser pulses are repetitively and simultaneously applied with the treatment radiation in order to excite acoustic waves, which are detected at the cornea with an ultrasonic transducer embedded in the contact lens and then are processed by PC.}, url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=732381}, year = {2011}, type = {Journal Article} } |
C.
Klatt,
M.
Saeger,
T.
Oppermann,
E.
Porksen,
F.
Treumer,
J.
Hillenkamp,
E.
Fritzer, and
J.
Roider,
Selective retina therapy for acute central serous chorioretinopathy, Br J Ophthalmol , vol. 95, no. 1, pp. 83-8, 2011.
Selective retina therapy for acute central serous chorioretinopathy, Br J Ophthalmol , vol. 95, no. 1, pp. 83-8, 2011.
Y. Miura,
Retinal pigment epithelium-choroid organ culture, Expert Rev Ophthalmol , vol. 6, no. 6, pp. 669-680, 2011.
Retinal pigment epithelium-choroid organ culture, Expert Rev Ophthalmol , vol. 6, no. 6, pp. 669-680, 2011.
DOI: | https://doi.org/10.1586/eop.11.70 |
Bibtex: | @article{Miura2011, author = {Miura, Yoko}, title = {Retinal pigment epithelium-choroid organ culture}, journal = {Expert Rev Ophthalmol}, volume = {6}, number = {6}, pages = {669-680}, abstract = {The retinal pigment epithelium (RPE) plays a vital role in retinal function, and therefore studies on RPE provide a significant benefit for our visual function. In order to obtain useful information from study results, choosing the suitable experimental model for each purpose of study is of great importance. Although RPE cell cultures are widely used, cells in cell culture have significantly different phenotypical characteristics from in vivo cells. The advantage of using native tissue is that cells in the tissue have close biological properties to in vivo conditions. This review describes basic characteristics of native RPE–choroid tissues in comparison to RPE cells in cell culture and introduces the possibility of preserving tissues in different culture systems. Advantages and disadvantages of organ culture and suitable studies with recent study results are also introduced.}, year = {2011} } |
T.
Bonin, and
P.
Koch,
Comparison of fast swept source full-field OCT with conventional scanning OCT, Rainer, A. Leitgeb and Brett, E. Bouma, Eds. SPIE, 2011. pp. 80911K.
Comparison of fast swept source full-field OCT with conventional scanning OCT, Rainer, A. Leitgeb and Brett, E. Bouma, Eds. SPIE, 2011. pp. 80911K.
A.
Obana,
R.
Brinkmann,
Y.
Gohto, and
K.
Nishimura,
A Case of Retinal Injury By A Violet Light-Emitting Diode, Retinal Cases and Brief Reports , vol. 5, no. 3, pp. 223-226 10.1097/ICB.0b013e3181e180d5, 2011.
A Case of Retinal Injury By A Violet Light-Emitting Diode, Retinal Cases and Brief Reports , vol. 5, no. 3, pp. 223-226 10.1097/ICB.0b013e3181e180d5, 2011.
R.
Orzekowsky-Schroeder,
A.
Klinger,
B.
Martensen,
M.
Blessenohl,
A.
Gebert, and
A.
Vogel,
In vivo spectral imaging of different cell types in the small intestine by two-photon excited autofluorescence, Journal of Biomedical Optics , vol. 16, no. 11, pp. 116025, 2011.
In vivo spectral imaging of different cell types in the small intestine by two-photon excited autofluorescence, Journal of Biomedical Optics , vol. 16, no. 11, pp. 116025, 2011.
D.
Hillmann,
C.
Luhrs,
T.
Bonin, and
P.
Koch,
Holoscopy--holographic optical coherence tomography, Opt Lett , vol. 36, no. 13, pp. 2390-2, 2011.
Holoscopy--holographic optical coherence tomography, Opt Lett , vol. 36, no. 13, pp. 2390-2, 2011.
DOI: | 10.1364/OL.36.002390 |
File: | 21725421 |
Bibtex: | @article{Hillmann2011-1, author = {Hillmann, D. and Luhrs, C. and Bonin, T. and Koch, P. and Huttmann, G.}, title = {Holoscopy--holographic optical coherence tomography}, journal = {Opt Lett}, volume = {36}, number = {13}, pages = {2390-2}, abstract = {Scanning optical coherence tomography (OCT) is limited in sensitivity and resolution by the restricted focal depth of the confocal detection scheme. Holoscopy, a combination of holography and Fourier-domain full-field OCT, is proposed as a way to detect photons from all depths of a sample volume simultaneously with uniform sensitivity and lateral resolution, even at high NAs. By using the scalar diffraction theory, as frequently applied in digital holographic imaging, we fully reconstruct the object field with depth-invariant imaging quality. In vivo imaging of human skin is demonstrated with an image quality comparable to conventionally scanned OCT.}, keywords = {Fingers Fourier Analysis Holography/*methods Humans Photons Tomography, Optical Coherence/*methods}, ISSN = {1539-4794 (Electronic) 0146-9592 (Linking)}, DOI = {10.1364/OL.36.002390}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21725421}, year = {2011}, type = {Journal Article} } |
M.
Szaszák,
P.
Steven,
K.
Shima,
R.
Orzekowsky-Schröder,
I.
König,
W.
Solbach, and
J.
Rupp,
Fluorescence Lifetime Imaging Unravels <italic>C. trachomatis</italic> Metabolism and Its Crosstalk with the Host Cell, PLoS Pathog , vol. 7, no. 7, pp. e1002108, 2011.
Fluorescence Lifetime Imaging Unravels <italic>C. trachomatis</italic> Metabolism and Its Crosstalk with the Host Cell, PLoS Pathog , vol. 7, no. 7, pp. e1002108, 2011.
S.
Tedsen,
C.
Doehn,
D.
Jocham, and
I.
Schmeling,
Comparison between a 1.92-mum fiber laser and a standard HF-dissection device for nephron-sparing kidney resection in a porcine in vivo study, Lasers Med Sci , vol. 26, no. 4, pp. 509-14, 2011.
Comparison between a 1.92-mum fiber laser and a standard HF-dissection device for nephron-sparing kidney resection in a porcine in vivo study, Lasers Med Sci , vol. 26, no. 4, pp. 509-14, 2011.
M.
Hagen-Eggert,
D.
Hillmann, and
P.
Koch,
Diffusion-sensitive Fourier-domain optical coherence tomography, James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin, Eds. SPIE, 2011. pp. 78892B.
Diffusion-sensitive Fourier-domain optical coherence tomography, James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin, Eds. SPIE, 2011. pp. 78892B.
File: | 12.873815.short |
Bibtex: | @inproceedings{Hagen-Eggert2011, author = {Hagen-Eggert, M. and Hillmann, D. and Koch, P. and Huttmann, G.}, title = {Diffusion-sensitive Fourier-domain optical coherence tomography}, editor = {James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin}, publisher = {SPIE}, volume = {7889}, pages = {78892B}, } |
A.
Obana,
R.
Brinkmann,
Y.
Gohto, and
K.
Nishimura,
A Case of Retinal Injury By A Violet Light-Emitting Diode, Retinal Cases and Brief Reports , vol. 5, no. 3, pp. 223--226 10.1097/ICB.0b013e3181e180d5, 2011.
A Case of Retinal Injury By A Violet Light-Emitting Diode, Retinal Cases and Brief Reports , vol. 5, no. 3, pp. 223--226 10.1097/ICB.0b013e3181e180d5, 2011.
J.
Horstmann,
A.
Baade, and
R.
Brinkmann,
Photoacoustic blood vessel detection during surgical laser interventions, SPIE ECBO, 2011. pp. 80920Z-80920Z-6.
Photoacoustic blood vessel detection during surgical laser interventions, SPIE ECBO, 2011. pp. 80920Z-80920Z-6.
File: | 12.889635 |
Bibtex: | @inproceedings{Horstmann2011, author = {Horstmann, Jens and Baade, Alexander and Brinkmann, Ralf}, title = {Photoacoustic blood vessel detection during surgical laser interventions}, publisher = {SPIE ECBO}, volume = {8092}, pages = {80920Z-80920Z-6}, note = {10.1117/12.889635}, abstract = {This paper presents a discussion about the potential of photoacoustics with regard to its application in surgical assistance during minimally invasive, laser assisted interventions. Aim of the work is the detection of obscured large blood vessels in order to prevent unintentional dissection. Based on spectroscopic investigations of the target tissue (liver), a wavelength for the photoacoustic excitation laser was chosen with respect to a high absorption contrast between the vessel and the surrounding liver tissue. An experimental setup featuring a simple liver model is created. Preliminary results show, that vessels with a diameter of 2 mm can be detected up to a distance of 1 mm from the treatment fibre. It is shown, that detection of acoustic waves induced inside liver is feasible over distances higher than 10 cm.}, url = {http://dx.doi.org/10.1117/12.889635}, type = {Conference Proceedings}, year = { 2011} } |
A.
Fritz,
A.
Zegelin,
L.
Ptaszynski, and
R.
Brinkmann,
Dynamics of laser induced micro bubble clusters on tissue phantoms, 2011. pp. 78850S-78850S-6.
Dynamics of laser induced micro bubble clusters on tissue phantoms, 2011. pp. 78850S-78850S-6.
File: | 12.875031.short |
Bibtex: | @inproceedings{Fritz2011, author = {Fritz, Andreas and Zegelin, Andrea and Ptaszynski, Lars and Birngruber, Reginald and Brinkmann, Ralf}, title = {Dynamics of laser induced micro bubble clusters on tissue phantoms}, volume = {7885}, pages = {78850S-78850S-6}, note = {10.1117/12.875031}, abstract = {Selective retina treatment (SRT) is a laser based method to treat retinal diseases associated with disorders of the retinal pigment epithelium (RPE) while preserving photoreceptors and choroid. Applying microsecond laser pulses to the 100- 200 strongly absorbing melanin granules inside the RPE cells induces transient micro bubbles which disrupt the cells. Aim of this work is to understand bubble dynamics in clusters with respect to the influence of the adjacent retina. Bubble dynamics were investigated in vitro on porcine RPE. An about 200 μm thick layer of agarose gel was applied to the RPE layer in order to simulate the mechanical properties of retina. Different laser pulse durations from 1 ns (532 nm, Nd:YAG) to 1.7 μs (527 nm, Nd:YLF) were used. The bubbles were investigated interferometrically (fiber interferometer @ 830 nm) and with fast flash photography (25 ns flash duration). Bubble lifetimes were measured. The results show that with retina phantoms the bubble formation threshold was reached at 2.5 times higher irradiation than without retina phantom for 1.7 μs laser pulses. The microbubbles generated with 1 ns laser pulses were almost not influenced by the agarose layer. Irradiation twofold over bubble formation threshold resulted in 3.5 times longer bubble lifetimes for μs and 2 times longer for ns pulse durations, respectively.}, url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/7885/1/Dynamics-of-laser-induced-micro-bubble-clusters-on-tissue-phantoms/10.1117/12.875031.short}, type = {Conference Proceedings}, year = { 2011} } |
T.
Bonin,
M.
Hagen-Eggert,
G.
Franke, and
P.
Koch,
Ultra highspeed in-vivo Fourier domain full-field OCT of the human retina, James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin, Eds. SPIE, 2011. pp. 788906.
Ultra highspeed in-vivo Fourier domain full-field OCT of the human retina, James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin, Eds. SPIE, 2011. pp. 788906.
A.
Vogel, and
V.
Venugopalan,
Pulsed Laser Ablation of Soft Biological Tissues, in Optical-Thermal Response of Laser-Irradiated Tissue , 2011, pp. 551-615.
Pulsed Laser Ablation of Soft Biological Tissues, in Optical-Thermal Response of Laser-Irradiated Tissue , 2011, pp. 551-615.
A.
Alex,
J.
Weingast,
B.
Hofer,
M.
Eibl,
M.
Binder,
H.
Pehamberger,
W.
Drexler, and
B.
Považay,
3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers, Imaging in Medicine , vol. 3, no. 6, pp. 653-674, 2011.
3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers, Imaging in Medicine , vol. 3, no. 6, pp. 653-674, 2011.
Weblink: | https://www.openaccessjournals.com/articles/3d-optical-coherence-tomography-for-clinical-diagnosis-of-nonmelanoma-skin-cancers-9179.html |
Bibtex: | @article{Alex2011, author = {Alex, A. and Weingast, J. and Hofer, B. and Eibl, M. and Binder, M. and Pehamberger, H. and Drexler, W. and Považay, B.}, title = {3D optical coherence tomography for clinical diagnosis of nonmelanoma skin cancers}, journal = {Imaging in Medicine}, volume = {3}, number = {6}, keyword = {cancer diagnosis, contrast-enhanced imaging, dermatology, functional imaging,microscopy, multimodal imaging, optical coherence tomography, optical imaging, tomography}, abstract = {High-resolution frequency domain optical coherence tomography (OCT) stands out amongst a range of novel dermatologic imaging technologies, with its good detection sensitivity around-100 dB, high measurement speeds allowing real-time image acquisition and its ability to acquire high definition cross-sectional and 3D tomograms of regions greater than 1 cm2, providing tissue information comparable to conventional histopathology without the need for any contrast agents. Typical axial and transverse resolutions of state-of-the-art OCT systems range between 1-10 m and approximately 20 m, respectively, depending on the employed wavelength region. This review investigates the significant progress accomplished in the field of dermatologic OCT with respect to other in vivo diagnostic methods for pre-excisional imaging of nonmelanoma skin cancers and specifically emphasizes state-of-the-art results achieved in different clinical pilot studies. Further technological extensions of OCT, various multimodal imaging approaches as well as potential clinical dermatologic applications are discussed. © 2011 Future Medicine Ltd.}, pages = {653-674}, url = {https://www.openaccessjournals.com/articles/3d-optical-coherence-tomography-for-clinical-diagnosis-of-nonmelanoma-skin-cancers-9179.html}, year = {2011}, keywords = {AG-Huber, OCT}, type = {Journal Article} } |
K.
Schlott,
S.
Koinzer,
L.
Ptaszynski,
S.
Luft,
M.
Bever,
J.
Roider, and
R.
Brinkmann,
Optoacoustic temperature determination and automatic coagulation control in rabbits, in Ophthalmic Technologies XXI , Ho, Fabrice Manns; Per G. Söderberg; Arthur, Eds. Proc. SPIE, 2011.
Optoacoustic temperature determination and automatic coagulation control in rabbits, in Ophthalmic Technologies XXI , Ho, Fabrice Manns; Per G. Söderberg; Arthur, Eds. Proc. SPIE, 2011.
File: | 12.875104 |
Bibtex: | @inproceedings{Schlott2011, author = {Schlott, Kerstin and Koinzer, Stefan and Ptaszynski, Lars and Luft, Susanne and Baade, Alex and Bever, Marco and Roider, Johann and Birngruber, Reginald and Brinkmann, Ralf}, title = {Optoacoustic temperature determination and automatic coagulation control in rabbits}, booktitle = {Ophthalmic Technologies XXI }, editor = {Ho, Fabrice Manns; Per G. Söderberg; Arthur}, publisher = {Proc. SPIE}, volume = {7885}, note = {10.1117/12.875104}, abstract = {Retinal laser photocoagulation is an established treatment method for many retinal diseases like macula edema or diabetic retinopathy. The selection of the laser parameters is so far based on post treatment evaluation of the lesion size and strength. Due to local pigment variations in the fundus and individual transmission the same laser parameters often lead to an overtreatment. Optoacoustic allows a non invasive monitoring of the retinal temperature increase during retinal laser irradiation by measuring the temperature dependent pressure amplitudes, which are induced by short probe laser pulses. A 75 ns/ 523 nm Nd:YLF was used as a probe laser at a repetition rate of 1 kHz, and a cw / 532 nm treatment laser for heating. A contact lens was modified with a ring-shaped ultrasonic transducer to detect the pressure waves at the cornea. Temperatures were collected for irradiations leading to soft or invisible lesions. Based on this data the threshold for denaturation was found. By analyzing the initial temperature increase, the further temperature development during irradiation could be predicted. An algorithm was found to calculate the irradiation time, which is needed for a soft lesion formation, from the temperature curve. By this it was possible to provide a real-time dosimetry by automatically switching off the treatment laser after the calculated irradiation time. Automatically controlled coagulations appear softer and more uniformly.}, keywords = {AutoPhoN}, url = {http://dx.doi.org/10.1117/12.875104}, type = {Conference Proceedings}, year = { 2011} } |
T.
Just,
H.
Pau, and
E.
Lankenau,
OCT in the field of laryngology: further perspectives, Nikiforos, Kollias and Bernard, Choi and Haishan, Zeng and Hyun Wook, Kang and Bodo, E. Knudsen and Brian, J. Wong and Justus, F. R. Ilgner and Kenton, W. Gregory and Guillermo, J. Tearney and Laura, Marcu and Henry, Hirschberg and Steen, J. Madsen and Andreas, Mandelis and Anita, Mahadevan-Jansen and Jansen, E. Duco, Eds. SPIE, 2011. pp. 78831W.
OCT in the field of laryngology: further perspectives, Nikiforos, Kollias and Bernard, Choi and Haishan, Zeng and Hyun Wook, Kang and Bodo, E. Knudsen and Brian, J. Wong and Justus, F. R. Ilgner and Kenton, W. Gregory and Guillermo, J. Tearney and Laura, Marcu and Henry, Hirschberg and Steen, J. Madsen and Andreas, Mandelis and Anita, Mahadevan-Jansen and Jansen, E. Duco, Eds. SPIE, 2011. pp. 78831W.
P.
Steven,
F.
Bock, and
C.
Cursiefen,
Intravital Two-Photon Microscopy of Immune Cell Dynamics in Corneal Lymphatic Vessels, PLoS One , vol. 6(10), pp. e26253, 2011.
Intravital Two-Photon Microscopy of Immune Cell Dynamics in Corneal Lymphatic Vessels, PLoS One , vol. 6(10), pp. e26253, 2011.
File: | journal.pone.0026253 |
Bibtex: | @article{Steven2011, author = {Steven, Philipp and Bock, Felix and Hüttmann, Gereon and Cursiefen, Claus}, title = {Intravital Two-Photon Microscopy of Immune Cell Dynamics in Corneal Lymphatic Vessels}, journal = {PLoS One}, volume = {6(10)}, url = { https://doi.org/10.1371/journal.pone.0026253}, pages = {e26253}, abstract = {<sec> <title>Background</title> <p>The role of lymphatic vessels in tissue and organ transplantation as well as in tumor growth and metastasis has drawn great attention in recent years.</p> </sec> <sec> <title>Methodology/Principal Findings</title> <p>We now developed a novel method using non-invasive two-photon microscopy to simultaneously visualize and track specifically stained lymphatic vessels and autofluorescent adjacent tissues such as collagen fibrils, blood vessels and immune cells in the mouse model of corneal neovascularization in vivo. The mouse cornea serves as an ideal tissue for this technique due to its easy accessibility and its inducible and modifiable state of pathological hem- and lymphvascularization.</p> <p>Neovascularization was induced by suture placement in corneas of Balb/C mice. Two weeks after treatment, lymphatic vessels were stained intravital by intrastromal injection of a fluorescently labeled LYVE-1 antibody and the corneas were evaluated in vivo by two-photon microscopy (TPM). Intravital TPM was performed at 710 nm and 826 nm excitation wavelengths to detect immunofluorescence and tissue autofluorescence using a custom made animal holder. Corneas were then harvested, fixed and analyzed by histology.</p> <p>Time lapse imaging demonstrated the first in vivo evidence of immune cell migration into lymphatic vessels and luminal transport of individual cells. Cells immigrated within 1–5.5 min into the vessel lumen. Mean velocities of intrastromal corneal immune cells were around 9 µm/min and therefore comparable to those of T-cells and macrophages in other mucosal surfaces.</p> </sec> <sec> <title>Conclusions</title> <p>To our knowledge we here demonstrate for the first time the intravital real-time transmigration of immune cells into lymphatic vessels. Overall this study demonstrates the valuable use of intravital autofluorescence two-photon microscopy in the model of suture-induced corneal vascularizations to study interactions of immune and subsequently tumor cells with lymphatic vessels under close as possible physiological conditions.</p> </sec>}, year = { 2011} } |
H.
Muller,
L.
Ptaszynski,
K.
Schlott,
T.
Bonin,
M.
Bever,
S.
Koinzer, and
R.
Brinkmann,
Imaging of temperature distribution and retinal tissue changes during photocoagulation by high speed OCT, James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin, Eds. SPIE, 2011. pp. 78890E.
Imaging of temperature distribution and retinal tissue changes during photocoagulation by high speed OCT, James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin, Eds. SPIE, 2011. pp. 78890E.
File: | 12.874788 |
Bibtex: | @inproceedings{Müller-2011-2, author = {Muller, Heike H. and Ptaszynski, Lars and Schlott, Kerstin and Bonin, Tim and Bever, Marco and Koinzer, Stefan and Birngruber, Reginald and Brinkmann, Ralf and Huttmann, Gereon}, title = {Imaging of temperature distribution and retinal tissue changes during photocoagulation by high speed OCT}, editor = {James, G. Fujimoto and Joseph, A. Izatt and Valery, V. Tuchin}, publisher = {SPIE}, volume = {7889}, pages = {78890E}, URL = { https://doi.org/10.1117/12.874788}, year = { 2011} } |
D.
Hillmann,
C.
Luhrs,
T.
Bonin,
P.
Koch, and
A.
Vogel,
Holoscopy: holographic optical coherence tomography, Rainer, A. Leitgeb and Brett, E. Bouma, Eds. Proc. SPIE, 2011. pp. 80911H.
Holoscopy: holographic optical coherence tomography, Rainer, A. Leitgeb and Brett, E. Bouma, Eds. Proc. SPIE, 2011. pp. 80911H.
2010
W.
Wieser,
B.
Biedermann,
T.
Klein,
C.
Eigenwillig, and
R.
Huber,
High-Quality 3-D Imaging with Multimegahertz OCT, Opt. Photon. News , vol. 21, no. 12, pp. 28-29, Dec. 2010. Optica Publishing Group.
High-Quality 3-D Imaging with Multimegahertz OCT, Opt. Photon. News , vol. 21, no. 12, pp. 28-29, Dec. 2010. Optica Publishing Group.
DOI: | 10.1364/OPN.21.12.000028 |
Bibtex: | @article{Wieser:10, author = {Wolfgang Wieser and Benjamin R. Biedermann and Thomas Klein and Christoph M. Eigenwillig and Robert Huber}, journal = {Opt. Photon. News}, keywords = {General; Analog to digital converters; Crystallography; Image quality; Optical coherence tomography; Real time imaging; Three dimensional imaging}, number = {12}, pages = {28--28}, publisher = {Optica Publishing Group}, title = {High-Quality 3-D Imaging withMultimegahertz OCT}, volume = {21}, month = {Dec}, year = {2010}, url = {https://www.optica-opn.org/abstract.cfm?URI=opn-21-12-28}, doi = {10.1364/OPN.21.12.000028}, abstract = {We have developed interferometric systems to measure nanosize structures and freeze their motion in time. Researchers have also suggested a method to extract both phase and amplitude information for crystallography.}, } |
B.
Biedermann,
W.
Wieser,
C.
Eigenwillig,
T.
Klein, and
R.
Huber,
Direct measurement of the instantaneous linewidth of rapidly wavelength-swept lasers, Opt. Lett. , vol. 35, no. 22, pp. 3733-3735, Nov. 2010. Optica Publishing Group.
Direct measurement of the instantaneous linewidth of rapidly wavelength-swept lasers, Opt. Lett. , vol. 35, no. 22, pp. 3733-3735, Nov. 2010. Optica Publishing Group.
DOI: | 10.1364/OL.35.003733 |
Bibtex: | @article{Biedermann:10, author = {Benjamin R. Biedermann and Wolfgang Wieser and Christoph M. Eigenwillig and Thomas Klein and Robert Huber}, journal = {Opt. Lett.}, keywords = {Optical coherence tomography; Lasers, tunable; Electrooptical modulators; Fourier transforms; Laser light; Laser sources; Optical coherence tomography; Swept lasers}, number = {22}, pages = {3733--3735}, publisher = {Optica Publishing Group}, title = {Direct measurement of the instantaneous linewidth of rapidly wavelength-swept lasers}, volume = {35}, month = {Nov}, year = {2010}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-35-22-3733}, doi = {10.1364/OL.35.003733}, abstract = {The instantaneous linewidth of rapidly wavelength-swept laser sources as used for optical coherence tomography (OCT) is of crucial interest for a deeper understanding of physical effects involved in their operation. Swept lasers for OCT, typically sweeping over ~15 THz in ~10$\mu$s, have linewidths of several gigahertz. The high optical-frequency sweep speed makes it impossible to measure the instantaneous spectrum with standard methods. Hence, up to now, experimental access to the instantaneous linewidth was rather indirect by the inverse Fourier transform of the coherence decay. In this Letter, we present a method by fast synchronous time gating and extraction of a ``snapshot'' of the instantaneous spectrum with an electro-optic modulator, which can subsequently be measured with an optical spectrum analyzer. This new method is analyzed in detail, and systematic artifacts, such as sideband generation due to the modulation and residual wavelength uncertainty due to the sweeping operation, are quantified. The method is checked for consistency with results from the common, more indirect measurement via coherence properties.}, } |
S.
Marschall,
T.
Klein,
W.
Wieser,
B.
Biedermann,
K.
Hsu,
K.
Hansen,
B.
Sumpf,
K.
Hasler,
G.
Erbert,
O.
Jensen,
C.
Pedersen,
R.
Huber, and
P.
Andersen,
Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier, Opt. Express , vol. 18, no. 15, pp. 15820-15831, 07 2010. Optica Publishing Group.
Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier, Opt. Express , vol. 18, no. 15, pp. 15820-15831, 07 2010. Optica Publishing Group.
DOI: | 10.1364/OE.18.015820 |
Bibtex: | @article{Marschall:10, author = {Sebastian Marschall and Thomas Klein and Wolfgang Wieser and Benjamin R. Biedermann and Kevin Hsu and Kim P. Hansen and Bernd Sumpf and Karl-Heinz Hasler and G\"{o}tz Erbert and Ole B. Jensen and Christian Pedersen and Robert Huber and Peter E. Andersen}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Semiconductor lasers; Semiconductor optical amplifiers; Dispersion; High speed imaging; Laser light; Optical delay lines; Optical fibers; Optical standards; Swept sources}, number = {15}, pages = {15820--15831}, publisher = {Optica Publishing Group}, title = {Fourier domain mode-locked swept source at 1050 nm based on a tapered amplifier}, volume = {18}, month = {Jul}, year = {2010}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-18-15-15820}, doi = {10.1364/OE.18.015820}, abstract = {While swept source optical coherence tomography (OCT) in the 1050 nm range is promising for retinal imaging, there are certain challenges. Conventional semiconductor gain media have limited output power, and the performance of high-speed Fourier domain mode-locked (FDML) lasers suffers from chromatic dispersion in standard optical fiber. We developed a novel light source with a tapered amplifier as gain medium, and investigated the FDML performance comparing two fiber delay lines with different dispersion properties. We introduced an additional gain element into the resonator, and thereby achieved stable FDML operation, exploiting the full bandwidth of the tapered amplifier despite high dispersion. The light source operates at a repetition rate of 116 kHz with an effective average output power in excess of 30 mW. With a total sweep range of 70 nm, we achieved an axial resolution of 15 {\textmu}m in air (~11 {\textmu}m in tissue) in OCT measurements. As our work shows, tapered amplifiers are suitable gain media for swept sources at 1050 nm with increased output power, while high gain counteracts dispersion effects in an FDML laser.}, } |
W.
Wieser,
B.
Biedermann,
T.
Klein,
C.
Eigenwillig, and
R.
Huber,
Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second, Opt. Express , vol. 18, no. 14, pp. 14685-14704, 07 2010. Optica Publishing Group.
Multi-megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second, Opt. Express , vol. 18, no. 14, pp. 14685-14704, 07 2010. Optica Publishing Group.
DOI: | 10.1364/OE.18.014685 |
Bibtex: | @article{Wieser:10, author = {Wolfgang Wieser and Benjamin R. Biedermann and Thomas Klein and Christoph M. Eigenwillig and Robert Huber}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Three-dimensional image acquisition; Lasers, tunable; Optical coherence tomography; Biological imaging; High speed imaging; Image processing algorithms; Image quality; Point spread function; Three dimensional imaging}, number = {14}, pages = {14685--14704}, publisher = {Optica Publishing Group}, title = {Multi-Megahertz OCT: High quality 3D imaging at 20 million A-scans and 4.5 GVoxels per second}, volume = {18}, month = {Jul}, year = {2010}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-18-14-14685}, doi = {10.1364/OE.18.014685}, abstract = {We present ultra high speed optical coherence tomography (OCT) with multi-megahertz line rates and investigate the achievable image quality. The presented system is a swept source OCT setup using a Fourier domain mode locked (FDML) laser. Three different FDML-based swept laser sources with sweep rates of 1, 2.6 and 5.2MHz are compared. Imaging with 4 spots in parallel quadruples the effective speed, enabling depth scan rates as high as 20.8 million lines per second. Each setup provides at least 98dB sensitivity and ~10{\textmu}m resolution in tissue. High quality 2D and 3D imaging of biological samples is demonstrated at full scan speed. A discussion about how to best specify OCT imaging speed is included. The connection between voxel rate, line rate, frame rate and hardware performance of the OCT setup such as sample rate, analog bandwidth, coherence length, acquisition dead-time and scanner duty cycle is provided. Finally, suitable averaging protocols to further increase image quality are discussed.}, } |
S.
Marschall,
T.
Klein,
W.
Wieser,
B.
Biedermann,
K.
Hsu,
B.
Sumpf,
K.
Hasler,
G.
Erbert,
O.
Jensen,
C.
Pedersen,
R.
Huber, and
P.
Andersen,
High-power FDML laser for swept source-OCT at 1060 nm, in Biophotonics: Photonic Solutions for Better Health Care II , Jürgen Popp and Wolfgang Drexler and Valery V. Tuchin and Dennis L. Matthews, Eds. SPIE, 052010. pp. 77150B.
High-power FDML laser for swept source-OCT at 1060 nm, in Biophotonics: Photonic Solutions for Better Health Care II , Jürgen Popp and Wolfgang Drexler and Valery V. Tuchin and Dennis L. Matthews, Eds. SPIE, 052010. pp. 77150B.
DOI: | 10.1117/12.854238 |
Bibtex: | @inproceedings{10.1117/12.854238, author = {Sebastian Marschall and Thomas Klein and Wolfgang Wieser and Benjamin Biedermann and Kevin Hsu and Bernd Sumpf and Karl-Heinz Hasler and G{\"o}tz Erbert and Ole B. Jensen and Christian Pedersen and Robert Huber and Peter E. Andersen}, title = {{High-power FDML laser for swept source-OCT at 1060 nm}}, volume = {7715}, booktitle = {Biophotonics: Photonic Solutions for Better Health Care II}, editor = {J{\"u}rgen Popp and Wolfgang Drexler and Valery V. Tuchin and Dennis L. Matthews}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {77150B}, abstract = {We present a novel frequency-swept light source working at 1060nm that utilizes a tapered amplifier as gain medium. These devices feature significantly higher saturation power than conventional semiconductor optical amplifiers and can thus improve the limited output power of swept sources in this wavelength range. We demonstrate that a tapered amplifier can be integrated into a fiber-based swept source and allows for high-speed FDML operation. The developed light source operates at a sweep rate of 116kHz with an effective average output power in excess of 30mW. With a total sweep range of 70 nm an axial resolution of 15 μm in air (~11μm in tissue) for OCT applications can be achieved.}, keywords = {optical coherence tomography, swept source, tunable laser, tapered amplifier, fourier domain mode-locking}, year = {2010}, doi = {10.1117/12.854238}, URL = {https://doi.org/10.1117/12.854238} } |
S.
Todor,
C.
Jirauschek,
B.
Biedermann, and
R.
Huber,
Linewidth Optimization of Fourier Domain Mode-Locked Lasers, Conference on Lasers and Electro-Optics 2010 , pp. CMW7, 05 2010. Optica Publishing Group.
Linewidth Optimization of Fourier Domain Mode-Locked Lasers, Conference on Lasers and Electro-Optics 2010 , pp. CMW7, 05 2010. Optica Publishing Group.
DOI: | 10.1364/CLEO.2010.CMW7 |
Bibtex: | @inproceedings{Todor:10, author = {Sebastian Todor and Christian Jirauschek and Benjamin Biedermann and Robert Huber}, booktitle = {Conference on Lasers and Electro-Optics 2010}, journal = {Conference on Lasers and Electro-Optics 2010}, keywords = {Lasers and laser optics; Laser theory; Lasers, tunable; Laser light; Laser operation; Mode locking; Optical amplifiers; Self phase modulation; Tunable lasers}, pages = {CMW7}, publisher = {Optica Publishing Group}, title = {Linewidth Optimization of Fourier Domain Mode-Locked Lasers}, year = {2010}, url = {https://opg.optica.org/abstract.cfm?URI=CLEO-2010-CMW7}, doi = {10.1364/CLEO.2010.CMW7}, abstract = {We theoretically and experimentally investigate the instantaneous linewidth of Fourier domain mode-locked lasers, yielding good agreement. Based on simulations, strategies are discussed to drastically reduce the laser linewidth.}, } |
S.
Marschall,
T.
Klein,
W.
Wieser,
B.
Biedermann,
K.
Hsu,
B.
Sumpf,
K.
Hasler,
G.
Erbert,
O.
Jensen,
C.
Pedersen,
R.
Huber, and
P.
Andersen,
FDML swept source at 1060 nm using a tapered amplifier, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. International Society for Optics and Photonics, 022010. pp. 75541H.
FDML swept source at 1060 nm using a tapered amplifier, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. International Society for Optics and Photonics, 022010. pp. 75541H.
DOI: | 10.1117/12.842011 |
Bibtex: | @inproceedings{10.1117/12.842011, author = {Sebastian Marschall and Thomas Klein and Wolfgang Wieser and Benjamin Biedermann and Kevin Hsu and Bernd Sumpf and Karl-Heinz Hasler and G{\"o}tz Erbert and Ole B. Jensen and Christian Pedersen and Robert Huber and Peter E. Andersen}, title = {{FDML swept source at 1060 nm using a tapered amplifier}}, volume = {7554}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV}, editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {75541H}, abstract = {We present a novel frequency-swept light source working at 1060nm that utilizes a tapered amplifier as gain medium. These devices feature significantly higher saturation power than conventional semiconductor optical amplifiers and can thus improve the limited output power of swept sources in this wavelength range. We demonstrate that a tapered amplifier can be integrated into a fiber-based swept source and allows for high-speed FDML operation. The developed light source operates at a sweep rate of 116kHz with an effective average output power in excess of 30mW. With a total sweep range of 70 nm an axial resolution of 15 μm in air (~11μm in tissue) for OCT applications can be achieved.}, keywords = {optical coherence tomography, swept source, tunable laser, tapered amplifier, fourier domain mode-locking}, year = {2010}, doi = {10.1117/12.842011}, URL = {https://doi.org/10.1117/12.842011} } |
2009
2010
T.
Just,
E.
Lankenau, and
H.
Pau,
An optical coherence tomography study for imaging the round window niche and the promontorium tympani, Nikiforos, Kollias and Bernard, Choi and Haishan, Zeng and Reza, S. Malek and Brian, J. Wong and Justus, F. R. Ilgner and Kenton, W. Gregory and Guillermo, J. Tearney and Laura, Marcu and Henry, Hirschberg and Steen, J. Madsen and Andreas, Mandelis and Anita, Mahadevan-Jansen and Jansen, E. Duco, Eds. SPIE, 2010. pp. 754833.
An optical coherence tomography study for imaging the round window niche and the promontorium tympani, Nikiforos, Kollias and Bernard, Choi and Haishan, Zeng and Reza, S. Malek and Brian, J. Wong and Justus, F. R. Ilgner and Kenton, W. Gregory and Guillermo, J. Tearney and Laura, Marcu and Henry, Hirschberg and Steen, J. Madsen and Andreas, Mandelis and Anita, Mahadevan-Jansen and Jansen, E. Duco, Eds. SPIE, 2010. pp. 754833.
File: | 12.848384 |
Bibtex: | @inproceedings{Just, author = {Just, T. and Lankenau, E. and Huttmann, G. and Pau, H. W.}, title = {An optical coherence tomography study for imaging the round window niche and the promontorium tympani}, editor = {Nikiforos, Kollias and Bernard, Choi and Haishan, Zeng and Reza, S. Malek and Brian, J. Wong and Justus, F. R. Ilgner and Kenton, W. Gregory and Guillermo, J. Tearney and Laura, Marcu and Henry, Hirschberg and Steen, J. Madsen and Andreas, Mandelis and Anita, Mahadevan-Jansen and Jansen, E. Duco}, publisher = {SPIE}, volume = {7548}, pages = {754833}, } |
Y.
Xie,
T.
Bonin,
S.
Loeffler,
G.
Huettmann,
V.
Tronnier, and
U.
Hofmann,
Fiber spectral domain optical coherence tomography for in vivo rat brain imaging, Jurgen, Popp and Wolfgang, Drexler and Valery, V. Tuchin and Dennis, L. Matthews, Eds. SPIE, 2010. pp. 77152F.
Fiber spectral domain optical coherence tomography for in vivo rat brain imaging, Jurgen, Popp and Wolfgang, Drexler and Valery, V. Tuchin and Dennis, L. Matthews, Eds. SPIE, 2010. pp. 77152F.
File: | 12.854798 |
Bibtex: | @inproceedings{Xie, author = {Xie, Y. and Bonin, T. and Loeffler, S. and Huettmann, G. and Tronnier, V. and Hofmann, U. G.}, title = {Fiber spectral domain optical coherence tomography for in vivo rat brain imaging}, editor = {Jurgen, Popp and Wolfgang, Drexler and Valery, V. Tuchin and Dennis, L. Matthews}, publisher = {SPIE}, volume = {7715}, pages = {77152F}, year = { 2010}, URL = { https://doi.org/10.1117/12.854798} } |
R.
Orzekowsky-Schroeder,
A.
Klinger,
A.
Schuth,
S.
Freidank,
A.
Gebert, and
A.
Vogel,
Intravital real-time study of tissue response to controlled laser-induced cavitation using 500-ps UV laser pulses focused in murine gut mucosa under online dosimetry and spectrally resolved 2-photon microscopy, Daniel, L. Farkas and Dan, V. Nicolau and Robert, C. Leif, Eds. SPIE, 2010. pp. 756815.
Intravital real-time study of tissue response to controlled laser-induced cavitation using 500-ps UV laser pulses focused in murine gut mucosa under online dosimetry and spectrally resolved 2-photon microscopy, Daniel, L. Farkas and Dan, V. Nicolau and Robert, C. Leif, Eds. SPIE, 2010. pp. 756815.
File: | 12.843102 |
Bibtex: | @inproceedings{Orzekowsky2010, author = {Orzekowsky-Schroeder, Regina and Klinger, Antje and Schuth, Anna and Freidank, Sebastian and Huttmann, Gereon and Gebert, Andreas and Vogel, Alfred}, title = {Intravital real-time study of tissue response to controlled laser-induced cavitation using 500-ps UV laser pulses focused in murine gut mucosa under online dosimetry and spectrally resolved 2-photon microscopy}, editor = {Daniel, L. Farkas and Dan, V. Nicolau and Robert, C. Leif}, publisher = {SPIE}, volume = {7568}, pages = {756815}, url = { https://doi.org/10.1117/12.843102}, year = { 2010} } |
P.
Rai,
S.
Mallidi,
X.
Zheng,
R.
Rahmanzadeh,
Y.
Mir,
S.
Elrington,
A.
Khurshid, and
T.
Hasan,
Development and applications of photo-triggered theranostic agents, Adv Drug Deliv Rev , vol. 62, no. 11, pp. 1094-124, 2010.
Development and applications of photo-triggered theranostic agents, Adv Drug Deliv Rev , vol. 62, no. 11, pp. 1094-124, 2010.
Weblink: | https://doi.org/10.1016/j.addr.2010.09.002 |
Bibtex: | @article{Rai, author = {Rai, P. and Mallidi, S. and Zheng, X. and Rahmanzadeh, R. and Mir, Y. and Elrington, S. and Khurshid, A. and Hasan, T.}, title = {Development and applications of photo-triggered theranostic agents}, journal = {Adv Drug Deliv Rev}, volume = {62}, number = {11}, pages = {1094-124}, note = {Rai, Prakash Mallidi, Srivalleesha Zheng, Xiang Rahmanzadeh, Ramtin Mir, Youssef Elrington, Stefan Khurshid, Ahmat Hasan, Tayyaba Nihms238162 Adv Drug Deliv Rev. 2010 Aug 30;62(11):1094-124. Epub 2010 Sep 19.}, abstract = {Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases.}, keywords = {Animals Anti-Infective Agents/diagnostic use/therapeutic use Antineoplastic Agents/diagnostic use/therapeutic use Diagnostic Imaging/ methods Drug Carriers/diagnostic use/therapeutic use Humans Infection/ diagnosis/ drug therapy Nanoparticles/diagnostic use/therapeutic use Neoplasms/ diagnosis/drug therapy/ therapy Phototherapy/ methods}, year = {2010} } |
M.
Mueller,
C.
Schulz-Wackerbarth,
P.
Steven,
E.
Lankenau,
T.
Bonin,
H.
Mueller,
A.
Brueggemann,
S.
Grisanti, and
G.
Huettmann,
Slit-lamp-adapted fourier-domain OCT for anterior and posterior segments: preliminary results and comparison to time-domain OCT, Curr Eye Res , vol. 35(8), pp. 722-32, 2010.
Slit-lamp-adapted fourier-domain OCT for anterior and posterior segments: preliminary results and comparison to time-domain OCT, Curr Eye Res , vol. 35(8), pp. 722-32, 2010.
DOI: | 10.3109/02713683.2010.481069 |
Bibtex: | @article{Müller-2010, author = {Mueller, M. and Schulz-Wackerbarth, C. and Steven, P. and Lankenau, E. and Bonin, T. and Mueller, H. and Brueggemann, A. and Birngruber, R. and Grisanti, S. and Huettmann, G.}, title = {Slit-lamp-adapted fourier-domain OCT for anterior and posterior segments: preliminary results and comparison to time-domain OCT}, journal = {Curr Eye Res}, volume = {35(8)}, DOI = { 10.3109/02713683.2010.481069}, year = { 2010}, pages = {722-32}, note = {Using Smart Source Parsing Aug}, abstract = {PURPOSE: To evaluate the diagnostic potential of a slit-lamp (SL)-adapted Fourier-domain (= spectral radar, SR) optical coherence tomography (OCT)-SL-SR-OCT-instrument as an in vivo imaging device for use in examinations of the anterior and posterior segments. MATERIALS AND METHODS: In a pilot study, 88 eyes from 70 healthy volunteers and patients were examined using a prototype Fourier-domain SL-SR-OCT system. Results were compared to those from the following commercially available systems: the 1310-nm SL-OCT (Heidelberg Engineering, Heidelberg, Germany) for anterior segment and the Stratus OCT (Zeiss Meditec, Jena, Germany) for posterior segment imaging. Our SL-SR-OCT provides 1025 axial scans, 5000 Hz line-scan frequency, scan length of up to 8 mm, axial depth in air of 3.5 mm, and resolution of 9 mum. For posterior visualization, a hand-held 78-diopter ophthalmoscopic lens was used. RESULTS: Our SL-SR-OCT system allowed simultaneous scanning with direct biomicroscopic and SL imaging of anterior and posterior segment structures. Anatomical structures and pathological changes were displayed with high resolution and excellent contrast. Measurements of corneal and retinal thickness were possible. In comparison to images obtained by the SL-OCT, our SL-SR-OCT boasted a higher resolution, thus providing more clinically relevant details of the corneal epithelium, internal structure of filtering blebs, etc. Complete imaging of the chamber angle was limited, however, due to the backscattering properties of the sclera at 830 nm. For posterior segment imaging, excellent delineation of the macula and optic nerve head details, with a distinct portrayal of macular pathology and retinal edema, was possible with SL-SR-OCT. CONCLUSION: SL-SR-OCT enables detailed imaging of physiological and pathological anterior and posterior segment structures. As a multi-purpose device, it offers a wide spectrum of applications, with high-quality OCT-imaging, in a comfortable setting without the need to move the patient.}, } |
J.
Roider,
S.
Liew,
C.
Klatt,
H.
Elsner,
E.
Poerksen, and
J.
Hillenkamp,
Selective retina therapy (SRT) for clinically significant diabetic macular edema, Graefes Arch Clin Exp Ophthalmol , vol. 248, no. 9, pp. 1263-72, 2010.
Selective retina therapy (SRT) for clinically significant diabetic macular edema, Graefes Arch Clin Exp Ophthalmol , vol. 248, no. 9, pp. 1263-72, 2010.
C.
Framme, and
G.
Panagakis,
Effects on Choroidal Neovascularization after Anti-VEGF Upload Using Intravitreal Ranibizumab, as Determined by Spectral Domain-Optical Coherence Tomography, Investigative Ophthalmology & Visual Science , vol. 51, no. 3, pp. 1671-1676, 2010.
Effects on Choroidal Neovascularization after Anti-VEGF Upload Using Intravitreal Ranibizumab, as Determined by Spectral Domain-Optical Coherence Tomography, Investigative Ophthalmology & Visual Science , vol. 51, no. 3, pp. 1671-1676, 2010.
DOI: | Doi 10.1167/Iovs.09-4496 |
File: | WOS:000275164300060 |
Bibtex: | @article{Framme2010, author = {Framme, C. and Panagakis, G. and Birngruber, R.}, title = {Effects on Choroidal Neovascularization after Anti-VEGF Upload Using Intravitreal Ranibizumab, as Determined by Spectral Domain-Optical Coherence Tomography}, journal = {Investigative Ophthalmology & Visual Science}, volume = {51}, number = {3}, pages = {1671-1676}, note = {563VW Times Cited:18 Cited References Count:17}, abstract = {PURPOSE. It is unclear whether anti-VEGF monotherapy in age-related macular degeneration (AMD) achieves morphologic CNV regression or only stops further CNV growth. In this study, spectral domain-optical coherence tomography (SD-OCT) was used to image CNV structure before and after anti-VEGF treatment. METHODS. Out of 107 consecutive patients, a prospective CNV evaluation was possible in 78 of them. Newly diagnosed CNV (classic CNV: n = 16; occult CNV: n = 54; minimal classic CNV: n = 8) due to AMD was imaged before and 4 weeks after anti-VEGF upload in three intravitreal injections of ranibizumab. Qualitative (structural changes) and quantitative measurements (diameter and thickness) of the CNV were obtained from the OCT images. RESULTS. Classic CNV components were observed above the RPE/photoreceptor complex, whereas occult CNVs stayed below. Of all postoperative OCTs, 59% revealed complete dry retinal structures, 27% showed reduced edema, and 14% showed edema remaining unchanged. Mean macular thickness decreased significantly from 427 to 303 mu m (P = 0.000). Qualitatively, overall CNV architecture appeared to be unchanged in 78%, was reduced in thickness in 18%, and became larger in 4%. Quantitatively, in all CNV subtypes, the diameter of the CNV lesions (preoperative, 2813 mu m; postoperative, 2804 mu m) did not change after treatment (classic CNV: P = 0.390; occult CNV: P = 0.405, minimal classic CNV: P = 0.092) independent of postoperative retinal edema. The overall thickness of the lesion, however, was reduced from 205 to 175 mu m (P = 0.000). Thickness reduction was significantly enhanced especially in CNV with classic components (n = 24; 252 to 197 mu m; P = 0.000; reduction, 22%), whereas reduction was smaller but also significant in occult CNV (183 to 164 mu m; P = 0.003; reduction, 10%). CONCLUSIONS. With SD-OCT, CNV size can be two-dimensionally determined and followed up after intravitreal anti-VEGF treatment. In only 4% of CNV was enlargement observed, whereas in 78%, CNV architecture appeared qualitatively unchanged, independent of retinal edema. Quantitative measurements underlined stable CNV diameters for all subtypes but revealed significant reduction of thickness especially for classic CNV components. In this series, ranibizumab monotherapy was able to morphologically stop further CNV growth but, in most patients, did not lead to a major regression of CNV, especially of its occult components. (Invest Ophthalmol Vis Sci. 2010;51:1671-1676) DOI:10.1167/iovs.09-4496}, keywords = {macular degeneration therapy verteporfin oct}, ISSN = {0146-0404}, DOI = {Doi 10.1167/Iovs.09-4496}, url = {<Go to ISI>://WOS:000275164300060}, year = {2010}, type = {Journal Article} } |
T.
Bonin,
G.
Franke,
M.
Hagen-Eggert, and
P.
Koch,
In vivo Fourier-domain full-field OCT of the human retina with 1.5 million A-lines/s., .... Opt Lett. 2010 Oct 15;35(20):3432-4. doi: 10.1364/OL.35.003432., 2010.
In vivo Fourier-domain full-field OCT of the human retina with 1.5 million A-lines/s., .... Opt Lett. 2010 Oct 15;35(20):3432-4. doi: 10.1364/OL.35.003432., 2010.
R.
Rahmanzadeh,
P.
Rai,
J.
Celli,
I.
Rizvi,
B.
Baron-Luhr,
J.
Gerdes, and
T.
Hasan,
Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer, Cancer Res , vol. 70, no. 22, pp. 9234-42, 2010.
Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer, Cancer Res , vol. 70, no. 22, pp. 9234-42, 2010.
DOI: | 10.1158/0008-5472.CAN-10-1190 |
Weblink: | https://doi.org/10.1016/j.addr.2010.09.002 |
Bibtex: | @article{Rahmanzadeh2010, author = {Rahmanzadeh, R. and Rai, P. and Celli, J. P. and Rizvi, I. and Baron-Luhr, B. and Gerdes, J. and Hasan, T.}, title = {Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer}, journal = {Cancer Res}, volume = {70}, number = {22}, pages = {9234-42}, note = {Using Smart Source Parsing Nov 15; Epub 2010 Nov 2}, abstract = {Targeting molecular markers and pathways implicated in cancer cell growth is a promising avenue for developing effective therapies. Although the Ki-67 protein (pKi-67) is a key marker associated with aggressively proliferating cancer cells and poor prognosis, its full potential as a therapeutic target has never before been successfully shown. In this regard, its nuclear localization presents a major hurdle because of the need for intracellular and intranuclear delivery of targeting and therapeutic moieties. Using a liposomally encapsulated construct, we show for the first time the specific delivery of a Ki-67-directed antibody and subsequent light-triggered death in the human ovarian cancer cell line OVCAR-5. Photoimmunoconjugate-encapsulating liposomes (PICEL) were constructed from anti-pKi-67 antibodies conjugated to fluorescein 5(6)-isothiocyanate, as a photoactivatable agent, followed by encapsulation in noncationic liposomes. Nucleolar localization of the PICELs was confirmed by confocal imaging. Photodynamic activation with PICELs specifically killed pKi-67-positive cancer cells both in monolayer and in three-dimensional (3D) cultures of OVCAR-5 cells, with the antibody TuBB-9 targeting a physiologically active form of pKi-67 but not with MIB-1, directed to a different epitope. This is the first demonstration of (a) the exploitation of Ki-67 as a molecular target for therapy and (b) specific delivery of an antibody to the nucleolus in monolayer cancer cells and in an in vitro 3D model system. In view of the ubiquity of pKi-67 in proliferating cells in cancer and the specificity of targeting in 3D multicellular acini, these findings are promising and the approach merits further investigation.}, year = {2010} } |
T.
Just,
E.
Lankenau,
F.
Prall,
H.
Pau, and
K.
Sommer,
Optical coherence tomography allows for the reliable identification of laryngeal epithelial dysplasia and for precise biopsy: a clinicopathological study of 61 patients undergoing microlaryngoscopy, Laryngoscope , vol. 120, no. 10, pp. 1964-70, 2010.
Optical coherence tomography allows for the reliable identification of laryngeal epithelial dysplasia and for precise biopsy: a clinicopathological study of 61 patients undergoing microlaryngoscopy, Laryngoscope , vol. 120, no. 10, pp. 1964-70, 2010.
M.
Wiesner,
J.
Ihlemann,
H.
Muller, and
E.
Lankenau,
Optical coherence tomography for process control of laser micromachining, Rev Sci Instrum , vol. 81, no. 3, pp. 033705, 2010.
Optical coherence tomography for process control of laser micromachining, Rev Sci Instrum , vol. 81, no. 3, pp. 033705, 2010.
J.
Probst,
D.
Hillmann,
E.
Lankenau,
S.
Oelckers, and
P.
Koch,
Optical coherence tomography with online visualization of more than seven rendered volumes per second, Journal of Biomedical Optics , vol. 15, no. 2, pp. 026014, 2010.
Optical coherence tomography with online visualization of more than seven rendered volumes per second, Journal of Biomedical Optics , vol. 15, no. 2, pp. 026014, 2010.
R.
Bombien,
C.
Lesche,
L.
Lozonschi,
M.
Feucker,
C.
Dahmen,
M.
Schunke,
J.
Cremer, and
G.
Lutter,
Percutaneous Aortic Valve Replacement: Emerging Tractability for Sufficient Intracardiac Resection of the Aortic Valve, Innovations (Phila) , vol. 5, no. 1, pp. 55-59, 2010.
Percutaneous Aortic Valve Replacement: Emerging Tractability for Sufficient Intracardiac Resection of the Aortic Valve, Innovations (Phila) , vol. 5, no. 1, pp. 55-59, 2010.
P.
Prahs,
A.
Walter,
R.
Regler, and
C.
Framme,
Selective retina therapy (SRT) in patients with geographic atrophy due to age-related macular degeneration, Graefes Arch Clin Exp Ophthalmol , vol. 248, no. 5, pp. 651--8, 2010.
Selective retina therapy (SRT) in patients with geographic atrophy due to age-related macular degeneration, Graefes Arch Clin Exp Ophthalmol , vol. 248, no. 5, pp. 651--8, 2010.
DOI: | 10.1007/s00417-009-1208-1 |
Bibtex: | @article{Prahs2010, title = {Selective retina therapy (SRT) in patients with geographic atrophy due to age-related macular degeneration}, author = {Prahs, P. and Walter, A. and Regler, R. and Theisen-Kunde, D. and Birngruber, R. and Brinkmann, R. and Framme, C.}, year = 2010, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = 248, number = 5, pages = {651--8}, doi = {10.1007/s00417-009-1208-1}, issn = {0721-832x}, note = {1435-702x Prahs, Philipp Walter, Andreas Regler, Roman Theisen-Kunde, Dirk Birngruber, Reginald Brinkmann, Ralf Framme, Carsten Journal Article Germany Graefes Arch Clin Exp Ophthalmol. 2010 May;248(5):651-8. doi: 10.1007/s00417-009-1208-1. Epub 2009 Dec 22.}, abstract = {BACKGROUND: For geographic atrophy (GA) due to age-related macular degeneration (AMD) there is so far no approved treatment option. Usually, increased autofluorescence (AF) levels of different patterns adjacent to the atrophic area indicate lipofuscin-laden retinal pigment epithelium (RPE) cells at a high risk for apoptosis. Herein, SRT was used to selectively treat these cells to stimulate RPE proliferation, in order to reduce or ideally stop further growth of the atrophic area. MATERIAL AND METHODS: Six eyes of six patients with bilateral equally pronounced GA were treated by SRT, while the fellow eye served as control. Irradiation was performed using a prototype SRT laser (Medical Laser Center Lubeck, Nd:YLF laser; 527 nm; 200 ns/1.7 micros pulse duration; 30 repetitive pulses at 100 Hz). Test lesions with increasing energies were applied at the lower vessel arcade to determine the individual angiographic and ophthalmoscopic threshold radiant exposures. Treatment was then performed in the area of increased AF adjacent to the GA using energies between both thresholds. The GA progression rates of treated and fellow eyes were evaluated. RESULTS: After a 1-year follow-up, a progression of the atrophic area was observed in the treated eyes (0.7-8.0 mm(2)/yr, mean 3.0 mm(2)/yr; 46%/yr) whereas the progression rates of the fellow eyes were insignificantly lower (0.46-4.04 mm(2)/yr, mean 1.9 mm(2)/yr; 30%/yr; p = 0.134). The progression rate in the treated eyes of two patients increased significantly, while in the other four patients, the progression rates were nearly the same between both eyes. Moreover, one of these two eyes showed an unexpected RPE reaction after treatment, since all laser lesions led to RPE atrophy and thus an accelerated enlargement of the GA occurred. CONCLUSION: SRT in the hyperautofluorescent areas of GA was not able to stop or slow down the progression of GA. However, modified treatment strategies might be more promising, e.g. placing the spots outside the hyperautofluorescent areas where RPE apoptosis is postulated. Moreover, SRT studies on GA might be more successfully performed on specific subgroups of GA, based on autofluorescence and other findings.}, keywords = {Aged Aged, 80 and over Disease Progression Fluorescein Angiography Fluorescence Follow-Up Studies Geographic Atrophy/etiology/physiopathology/*surgery Humans Image Processing, Computer-Assisted *Laser Coagulation Lasers, Solid-State/therapeutic use Lipofuscin/metabolism Macular Degeneration/complications/physiopathology/*surgery Ophthalmologic Surgical Procedures/*methods Pilot Projects Prognosis Retinal Pigment Epithelium/metabolism}, type = {Journal Article} } |
Y.
Miura,
R.
Orzekowsky-Schröder,
N.
Koop,
P.
Steven,
M.
Szaszák, and
R.
Brinkmann,
Appearance of autofluorescence in RPE cells at the rim of photocoagulation, in FLIM 2010 - Symposium "Fluorescence Lifetime Imaging of the Human Retina" , 2010.
Appearance of autofluorescence in RPE cells at the rim of photocoagulation, in FLIM 2010 - Symposium "Fluorescence Lifetime Imaging of the Human Retina" , 2010.
R.
Rahmanzadeh,
P.
Rai,
J.
Gerdes, and
T.
Hasan,
Targeted light-inactivation of the Ki-67 protein using theranostic liposomes leads to death of proliferating cells, Samuel, Achilefu and Ramesh, Raghavachari, Eds. SPIE, 2010. pp. 757602.
Targeted light-inactivation of the Ki-67 protein using theranostic liposomes leads to death of proliferating cells, Samuel, Achilefu and Ramesh, Raghavachari, Eds. SPIE, 2010. pp. 757602.
DOI: | 10.1117/12.843850 |
Bibtex: | @inproceedings{Rahmanzadeh, author = {Rahmanzadeh, Ramtin and Rai, Prakash and Gerdes, Johannes and Hasan, Tayyaba}, title = {Targeted light-inactivation of the Ki-67 protein using theranostic liposomes leads to death of proliferating cells}, editor = {Samuel, Achilefu and Ramesh, Raghavachari}, publisher = {SPIE}, volume = {7576}, pages = {757602}, year = {2010}, doi ={10.1117/12.843850}, keywords = {Nanotechnology, Ovarian Cancer, Proliferative Index, Photodynamic Therapy,Antibody} } |
Y.
Miura,
A.
Klettner, and
J.
Roider,
VEGF antagonists decrease barrier function of retinal pigment epithelium in vitro: possible participation of intracellular glutathione, Invest Ophthalmol Vis Sci , vol. 51, no. 9, pp. 4848-55, 2010.
VEGF antagonists decrease barrier function of retinal pigment epithelium in vitro: possible participation of intracellular glutathione, Invest Ophthalmol Vis Sci , vol. 51, no. 9, pp. 4848-55, 2010.
DOI: | 10.1167/iovs.09-4699 |
Bibtex: | @article{Miura2010, author = {Miura, Y and Klettner, A and Roider, J}, title = {VEGF antagonists decrease barrier function of retinal pigment epithelium in vitro: possible participation of intracellular glutathione}, journal = {Invest Ophthalmol Vis Sci}, volume = {51}, number = {9}, pages = {4848-55}, note = {Miura, Yoko Klettner, Alexa Roider, Johann United States Invest Ophthalmol Vis Sci. 2010 Sep;51(9):4848-55. Epub 2010 Apr 30.}, abstract = {PURPOSE: To investigate the influence of VEGF antagonists on the barrier function of the retinal pigment epithelium and underlying mechanisms. METHODS: Porcine RPE cells were cultured on six-well membrane inserts. The cells were exposed to bevacizumab (62.5 microg/mL) or ranibizumab (25 microg/mL) for 24 hours (short term) or 9 days (long term). Transepithelial flux of FITC-dextran and intracellular levels of reduced glutathione (GSH) at normal and low-glucose conditions were investigated at different points in time. The influence of the addition of triamcinolone acetonide (TA) was investigated. The effect of GSH depletion on RPE permeability was examined using L-buthionine sulfoximine (BSO), a gamma-glutamylcysteine synthethase inhibitor. RESULTS: After short-term exposure, VEGF antagonists increased the transepithelial flux of FITC-dextran significantly on day 2. Bevacizumab, but not ranibizumab, increased permeability up to 9 days. Under long-term exposure, both drugs enhanced permeability for 7 days; bevacizumab had the stronger effect. The addition of TA inhibited this increase. At the ninth day of short- and long-term exposure, bevacizumab-exposed cells, but not ranibizumab-exposed cells, exhibited a significantly lower GSH level. In the low-glucose condition, both drugs accelerated the decrease of intracellular GSH for the first 48 hours. GSH depletion increased the permeability of retinal pigment epithelium. TA had no effect on BSO-induced GSH depletion. CONCLUSIONS: The results suggest that bevacizumab and ranibizumab may decrease RPE barrier function, with bevacizumab exhibiting a prolonged and more profound effect. Combination with TA is thought to be beneficial because of its protective effect on stabilizing RPE junctional integrity.}, keywords = {Angiogenesis Inhibitors/ pharmacology Animals Antibodies, Monoclonal/ pharmacology Antibodies, Monoclonal, Humanized Buthionine Sulfoximine/pharmacology Cell Membrane Permeability/drug effects Cells, Cultured Dextrans/pharmacokinetics Enzyme Inhibitors/pharmacology Fluorescein-5-isothiocyanate/analogs & derivatives/pharmacokinetics Glucose/pharmacology Glutathione/ metabolism Retinal Pigment Epithelium/cytology/ drug effects/ metabolism Swine Tight Junctions/drug effects/metabolism Vascular Endothelial Growth Factor A/ antagonists & inhibitors/metabolis AutoPhoN}, ISSN = {1552-5783 (Electronic) 0146-0404 (Linking)}, DOI = {10.1167/iovs.09-4699}, year = { 2010}, type = {Journal Article} } |
Y.
Miura,
A.
Klettner,
B.
Noelle,
H.
Hasselbach, and
J.
Roider,
Change of morphological and functional characteristics of retinal pigment epithelium cells during cultivation of retinal pigment epithelium-choroid perfusion tissue culture, Ophthalmic Res , vol. 43, no. 3, pp. 122-33, 2010.
Change of morphological and functional characteristics of retinal pigment epithelium cells during cultivation of retinal pigment epithelium-choroid perfusion tissue culture, Ophthalmic Res , vol. 43, no. 3, pp. 122-33, 2010.
DOI: | 10.1159/000252979 |
Bibtex: | @article{Miura2010, author = {Miura, Y. and Klettner, A. and Noelle, B. and Hasselbach, H. and Roider, J.}, title = {Change of morphological and functional characteristics of retinal pigment epithelium cells during cultivation of retinal pigment epithelium-choroid perfusion tissue culture}, journal = {Ophthalmic Res}, volume = {43}, number = {3}, pages = {122-33}, note = {1423-0259 Miura, Yoko Klettner, Alexa Noelle, Bernhard Hasselbach, Heike Roider, Johann Journal Article Switzerland Ophthalmic Res. 2010;43(3):122-33. doi: 10.1159/000252979. Epub 2009 Oct 29.}, abstract = {AIMS: To evaluate the changes of morphological and functional characteristics of the retinal pigment epithelium (RPE)-choroid perfusion culture during cultivation. METHODS: PorcineRPE-choroid tissue was cultivated in a perfusion tissue culture system. After the indicated times, histology, immunolocalization of collagen IV and von Willebrand factor, RPE cell viability with calcein-AM, TUNEL assay and occludin immunolocalization of RPE cells were examined. The tissue was treated with selective RPE treatment laser after different time periods and the wound healing response was characterized. Vascular endothelial growth factor secretion was measured by enzyme-linked immunosorbent assay. RESULTS: On day 8, prominent morphological degenerative changes of RPE cells were observed in histology. According to the immunohistochemistry for collagen IV, the Bruch's membrane did not display any obvious decomposition until day 8. Von Willebrand factor staining decreased during cultivation, especially at the choriocapillaris. Calcein-AM staining and TUNEL assay displayed the increase of apoptotic changes in only a minority of the cells on day 4, but in many cells on day 8. Occludin delocalization was observed on day 8. Selective RPE treatment laser-produced wounds were completely closed by monolayer RPE when wounded on fresh and 3-day-old cultures, but not when wounded on 6-day-old cultures. Vascular endothelial growth factor secretion was stable between days 2 and 5, but increased after that. CONCLUSION: Under the stated culture perfusion conditions, porcine RPE-choroid tissue was suitable for experimentation up to 5 days of maintenance.}, keywords = {Animals *Apoptosis Bruch Membrane/pathology Cell Survival Choroid/metabolism/*pathology/surgery Collagen Type IV/metabolism Enzyme-Linked Immunosorbent Assay Fluoresceins/metabolism Immunoenzyme Techniques In Situ Nick-End Labeling Laser Therapy Membrane Proteins/metabolism Occludin Organ Culture Techniques Retinal Pigment Epithelium/metabolism/*pathology/surgery Swine Time Factors Vascular Endothelial Growth Factor A/metabolism Wound Healing von Willebrand Factor/metabolism}, ISSN = {0030-3747}, DOI = { 10.1159/000252979}, year = {2010}, type = {Journal Article} } |
2009
C.
Jirauschek,
B.
Biedermann, and
R.
Huber,
A theoretical description of Fourier domain mode locked lasers, Opt. Express , vol. 17, no. 26, pp. 24013-24019, Dec. 2009. Optica Publishing Group.
A theoretical description of Fourier domain mode locked lasers, Opt. Express , vol. 17, no. 26, pp. 24013-24019, Dec. 2009. Optica Publishing Group.
DOI: | 10.1364/OE.17.024013 |
Bibtex: | @article{Jirauschek:09, author = {Christian Jirauschek and Benjamin Biedermann and Robert Huber}, journal = {Opt. Express}, keywords = {Laser theory; Lasers, tunable; Optical coherence tomography; Fourier domain mode locking; Laser modes; Laser sources; Mode locking; Optical amplifiers; Spontaneous emission}, number = {26}, pages = {24013--24019}, publisher = {Optica Publishing Group}, title = {A theoretical description of Fourier domain mode locked lasers}, volume = {17}, month = {Dec}, year = {2009}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-17-26-24013}, doi = {10.1364/OE.17.024013}, abstract = {The first theoretical model of Fourier domain mode locking operation is presented. A specially tailored dynamic equation in a moving spectral reference frame is derived, enabling efficient numerical treatment, despite the broad laser spectrum and the extremely long cavity. The excellent agreement of the presented theory with experiment over a wide range of operation parameters enables a quantitative assessment of the relevant physical effects, such as the spectral loss modulation and gain saturation dynamics, amplified spontaneous emission, linewidth enhancement, and self-phase modulation.}, } |
W.
Wieser,
B.
Biedermann,
T.
Klein,
C.
Eigenwillig, and
R.
Huber,
Ultra-rapid dispersion measurement in optical fibers, Opt. Express , vol. 17, no. 25, pp. 22871-22878, Dec. 2009. Optica Publishing Group.
Ultra-rapid dispersion measurement in optical fibers, Opt. Express , vol. 17, no. 25, pp. 22871-22878, Dec. 2009. Optica Publishing Group.
DOI: | 10.1364/OE.17.022871 |
Bibtex: | @article{Wieser:09, author = {Wolfgang Wieser and Benjamin R. Biedermann and Thomas Klein and Christoph M. Eigenwillig and Robert Huber}, journal = {Opt. Express}, keywords = {Fiber characterization; Fiber properties; Fibers, single-mode; Optical communications; Lasers, tunable; Dispersion; Optical standards and testing; Lasers, fiber; Fiber optic amplifiers; Laser modes; Laser sources; Mode locking; Optical networks; Thermal effects}, number = {25}, pages = {22871--22878}, publisher = {Optica Publishing Group}, title = {Ultra-rapid dispersion measurement in optical fibers}, volume = {17}, month = {Dec}, year = {2009}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-17-25-22871}, doi = {10.1364/OE.17.022871}, abstract = {We present a novel method to measure the chromatic dispersion of fibers with lengths of several kilometers. The technique is based on a rapidly swept Fourier domain mode locked laser driven at 50kHz repetition rate. Amplitude modulation with 400MHz and phase analysis yield the dispersion values over a 130nm continuous wavelength tuning range covering C and L band. The high acquisition speed of 10{\textmu}s for individual wavelength-resolved traces $\Delta$t($\lambda$) can reduce effects caused by thermal drift and acoustic vibrations. It enables real-time monitoring with update rates \>100Hz even when averaging several hundred acquisitions for improved accuracy.}, } |
R. Huber,
Advances in Fourier domain OCT, in 2009 IEEE LEOS Annual Meeting Conference Proceedings , IEEE, Oct.2009. pp. 201-202.
Advances in Fourier domain OCT, in 2009 IEEE LEOS Annual Meeting Conference Proceedings , IEEE, Oct.2009. pp. 201-202.
DOI: | 10.1109/LEOS.2009.5343314 |
Bibtex: | @INPROCEEDINGS{5343314, author={Huber, Robert}, booktitle={2009 IEEE LEOS Annual Meeting Conference Proceedings}, title={Advances in Fourier domain OCT}, year={2009}, volume={}, number={}, pages={201-202}, abstract={In optical coherence tomography, the introduction of so called ldquoFrequency Domainrdquo techniques, i.e. spectrally resolved detection, had a dramatic impact on these biomedical imaging systems. The current status and future developments will be discussed.}, keywords={}, doi={10.1109/LEOS.2009.5343314}, ISSN={1092-8081}, month={Oct},} |
E.
Ploetz,
B.
Marx,
T.
Klein,
R.
Huber, and
P.
Gilch,
A 75 MHz light source for femtosecond stimulated raman microscopy, Opt. Express , vol. 17, no. 21, pp. 18612-18620, Oct. 2009. Optica Publishing Group.
A 75 MHz light source for femtosecond stimulated raman microscopy, Opt. Express , vol. 17, no. 21, pp. 18612-18620, Oct. 2009. Optica Publishing Group.
DOI: | 10.1364/OE.17.018612 |
Bibtex: | @article{Ploetz:09, author = {E. Ploetz and B. Marx and T. Klein and R. Huber and P. Gilch}, journal = {Opt. Express}, keywords = {Laser amplifiers; Ultrafast lasers; Nonlinear microscopy; Raman microscopy; Laser sources; Raman microscopy; Raman scattering; Raman spectroscopy; Stimulated Raman scattering; Time resolved spectroscopy}, number = {21}, pages = {18612--18620}, publisher = {Optica Publishing Group}, title = {A 75 MHz Light Source for Femtosecond Stimulated Raman Microscopy}, volume = {17}, month = {Oct}, year = {2009}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-17-21-18612}, doi = {10.1364/OE.17.018612}, abstract = {In femtosecond stimulated Raman microscopy (FSRM) a spectrally broad pulse (Raman probe) and a spectrally narrow pulse (Raman pump) interact in a sample and thereby generate a Raman spectrum of the focal volume. Here a novel light source for FSRM is presented. It consists of an 8-fs laser (repetition rate of 75 MHz) operating as Raman probe. A Yb3$+$ based fiber amplifier generates the Raman pump light at 980 nm. The amplifier is seeded by the spectral wing of the 8-fs laser output which ensures synchronisation of pump and probe pulses. Spectral and temporal characteristics of these pulses are reported and simultaneous recording of broadband Raman spectra relying on these pulses is demonstrated.}, } |
C.
Eigenwillig,
B.
Biedermann,
W.
Wieser, and
R.
Huber,
Wavelength swept amplified spontaneous emission source, Opt. Express , vol. 17, no. 21, pp. 18794-18807, Oct. 2009. Optica Publishing Group.
Wavelength swept amplified spontaneous emission source, Opt. Express , vol. 17, no. 21, pp. 18794-18807, Oct. 2009. Optica Publishing Group.
DOI: | 10.1364/OE.17.018794 |
Bibtex: | @article{Eigenwillig:09, author = {Christoph M. Eigenwillig and Benjamin R. Biedermann and Wolfgang Wieser and Robert Huber}, journal = {Opt. Express}, keywords = {Noise in imaging systems; Optical coherence tomography; Fabry-Perot; Filters; Interferometry; Lasers, tunable; Fiber Bragg grating sensors; Image quality; Light properties; Light sources; Medical imaging; Mode locking}, number = {21}, pages = {18794--18807}, publisher = {Optica Publishing Group}, title = {Wavelength swept amplified spontaneous emission source}, volume = {17}, month = {Oct}, year = {2009}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-17-21-18794}, doi = {10.1364/OE.17.018794}, abstract = {We present a new, alternative approach to realize a wavelength swept light source with no fundamental limit to sweep speed. Amplified spontaneous emission (ASE) light alternately passes a cascade of optical gain elements and tunable optical bandpass filters. We show that for high sweep speeds, the control signal for the different filters has to be applied with a defined, precise phase delay on the order of nanoseconds, to compensate for the light propagation time between the filters and ensure optimum operation. At a center wavelength of 1300 nm sweep rates of 10 kHz, 100 kHz and 340 kHz over a sweep range of 100 nm full width and an average power of 50 mW are demonstrated. For application in optical coherence tomography (OCT), an axial resolution of 12 {\textmu}m (air), a sensitivity of 120 dB (50 mW) and a dynamic range of 50 dB are achieved and OCT imaging is demonstrated. Performance parameters like coherence properties and relative intensity noise (RIN) are quantified, discussed and compared to the performance of Fourier Domain Mode Locked (FDML) lasers. Physical models for the observed difference in performance are provided.}, } |
R.
Leonhardt,
B.
Biedermann,
W.
Wieser, and
R.
Huber,
Nonlinear optical frequency conversion of an amplified Fourier Domain Mode Locked (FDML) laser., Opt. Express , vol. 17, no. 19, pp. 16801-16808, 09 2009. Optica Publishing Group.
Nonlinear optical frequency conversion of an amplified Fourier Domain Mode Locked (FDML) laser., Opt. Express , vol. 17, no. 19, pp. 16801-16808, 09 2009. Optica Publishing Group.
DOI: | 10.1364/OE.17.016801 |
Bibtex: | @article{Leonhardt:09, author = {Rainer Leonhardt and Benjamin R. Biedermann and Wolfgang Wieser and Robert Huber}, journal = {Opt. Express}, keywords = {Fiber optics amplifiers and oscillators; Fibers, erbium; Lasers, tunable; Nonlinear optics, fibers; Nonlinear optics, four-wave mixing; Wavelength conversion devices ; Four wave mixing; Fourier domain mode locking; Laser sources; Optical coherence tomography; Optical frequency conversion; Semiconductor optical amplifiers}, number = {19}, pages = {16801--16808}, publisher = {Optica Publishing Group}, title = {Nonlinear optical frequency conversion of an amplified Fourier Domain Mode Locked (FDML) laser}, volume = {17}, month = {Sep}, year = {2009}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-17-19-16801}, doi = {10.1364/OE.17.016801}, abstract = {We report on the highly efficient non-linear optical frequency conversion of the wavelength swept output from a Fourier Domain Mode Locked (FDML) laser. Different concepts for power scaling of FDML lasers by post-amplification with active fibers are presented. A two-stage post-amplification of an FDML laser with an amplification factor of 300 up to a peak power of 1.5 W is used to supply sufficient power levels for non-linear conversion. Using a single-mode dispersion shifted fiber (DSF), we convert this amplified output that covers the region between 1541 nm and 1545 nm to a wavelength range from 1572 nm to 1663 nm via modulation instability (MI). For this four wave mixing process we observe an efficiency of ~40\%. The anti-Stokes signal between 1435 nm and 1516 nm was observed with lower conversion efficiency. In addition to shifting the wavelength, the effect of MI also enables a substantial increase in the wavelength sweep rate of the FDML laser by a factor of ~50 to 0.55 nm/ns.}, } |
M.
Gora,
K.
Karnowski,
M.
Szkulmowski,
B.
Kaluzny,
R.
Huber,
A.
Kowalczyk, and
M.
Wojtkowski,
Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range, Opt. Express , vol. 17, no. 17, pp. 14880-14894, 08 2009. Optica Publishing Group.
Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range, Opt. Express , vol. 17, no. 17, pp. 14880-14894, 08 2009. Optica Publishing Group.
DOI: | 10.1364/OE.17.014880 |
Bibtex: | @article{Gora:09, author = {Michalina Gora and Karol Karnowski and Maciej Szkulmowski and Bartlomiej J. Kaluzny and Robert Huber and Andrzej Kowalczyk and Maciej Wojtkowski}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Ophthalmology; Crystalline lens; High speed imaging; Imaging systems; Ophthalmic imaging; Optical coherence tomography; Three dimensional imaging}, number = {17}, pages = {14880--14894}, publisher = {Optica Publishing Group}, title = {Ultra high-speed swept source OCT imaging of the anterior segment of human eye at 200 kHz with adjustable imaging range}, volume = {17}, month = {Aug}, year = {2009}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-17-17-14880}, doi = {10.1364/OE.17.014880}, abstract = {We present an application of in vivo anterior segment imaging of the human eye with an ultrahigh speed swept source OCT instrument. For this purpose, a dedicated OCT system was designed and constructed. This instrument enables axial zooming by automatic reconfiguration of spectral sweep range; an enhanced imaging range mode enables imaging of the entire anterior segment while a high axial resolution mode provides detailed morphological information of the chamber angle and the cornea. The speed of 200,000 lines/s enables high sampling density in three-dimensional imaging of the entire cornea in 250 ms promising future applications of OCT for optical corneal topography, pachymetry and elevation maps. The results of a preliminary quantitative corneal analysis based on OCT data free form motion artifacts are presented. Additionally, a volumetric and real time reconstruction of dynamic processes, like pupillary reaction to light stimulus or blink-induced contact lens movements are demonstrated.}, } |
G.
Palte,
W.
Wieser,
B.
Biedermann,
C.
Eigenwillig, and
R.
Huber,
Fourier domain mode locked (FDML) lasers for polarization sensitive OCT, in Optical Coherence Tomography and Coherence Techniques IV , Peter E. Andersen and Brett E. Bouma, Eds. SPIE, 072009. pp. 73720M.
Fourier domain mode locked (FDML) lasers for polarization sensitive OCT, in Optical Coherence Tomography and Coherence Techniques IV , Peter E. Andersen and Brett E. Bouma, Eds. SPIE, 072009. pp. 73720M.
DOI: | 10.1117/12.831835 |
Bibtex: | @inproceedings{10.1117/12.831835, author = {Gesa Palte and Wolfgang Wieser and Benjamin R. Biedermann and Christoph M. Eigenwillig and Robert Huber}, title = {{Fourier domain mode locked (FDML) lasers for polarization sensitive OCT}}, volume = {7372}, booktitle = {Optical Coherence Tomography and Coherence Techniques IV}, editor = {Peter E. Andersen and Brett E. Bouma}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {73720M}, abstract = {A Fourier Domain mode-locked (FDML) laser for polarization sensitive optical coherence tomography (OCT) is presented. The laser generates an alternating sequence of wavelength sweeps with their polarization states 90° separated on the Poincare sphere.}, keywords = {Lasers, tunable, optical coherence tomography, lasers, imaging systems, polarization, fiber}, year = {2009}, doi = {10.1117/12.831835}, URL = {https://doi.org/10.1117/12.831835} } |
C.
Eigenwillig,
B.
Biedermann,
W.
Wieser, and
R.
Huber,
Wavelength swept ASE source, in Optical Coherence Tomography and Coherence Techniques IV , Peter E. Andersen and Brett E. Bouma, Eds. SPIE, 072009. pp. 73720O.
Wavelength swept ASE source, in Optical Coherence Tomography and Coherence Techniques IV , Peter E. Andersen and Brett E. Bouma, Eds. SPIE, 072009. pp. 73720O.
DOI: | 10.1117/12.831831 |
Bibtex: | @inproceedings{10.1117/12.831831, author = {Christoph M. Eigenwillig and Benjamin R. Biedermann and Wolfgang Wieser and Robert Huber}, title = {{Wavelength swept ASE source}}, volume = {7372}, booktitle = {Optical Coherence Tomography and Coherence Techniques IV}, editor = {Peter E. Andersen and Brett E. Bouma}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {73720O}, abstract = {We present a novel wavelength swept light source for Optical Coherence Tomography (OCT). Arbitrary sweep rates up to 2x170kHz are achieved by phase-shifted control of two optical bandpass-filters to compensate light propagation effects.}, keywords = {amplified spontaneous emission, tunable lasers, lasers, optical coherence tomography, optical frequency domain imaging}, year = {2009}, doi = {10.1117/12.831831}, URL = {https://doi.org/10.1117/12.831831} } |
B.
Biedermann,
W.
Wieser,
C.
Eigenwillig, and
R.
Huber,
Recent developments in Fourier domain mode locked lasers for optical coherence tomography: imaging at 1310 nm vs. 1550 nm wavelength, Journal of Biophotonics , vol. 2, no. 6-7, pp. 357-363, 07 2009.
Recent developments in Fourier domain mode locked lasers for optical coherence tomography: imaging at 1310 nm vs. 1550 nm wavelength, Journal of Biophotonics , vol. 2, no. 6-7, pp. 357-363, 07 2009.
DOI: | 10.1002/jbio.200910028 |
Bibtex: | @article{https://doi.org/10.1002/jbio.200910028, author = {Biedermann, Benjamin R. and Wieser, Wolfgang and Eigenwillig, Christoph M. and Huber, Robert}, title = {Recent developments in Fourier Domain Mode Locked lasers for optical coherence tomography: Imaging at 1310 nm vs. 1550 nm wavelength}, journal = {Journal of Biophotonics}, volume = {2}, number = {6-7}, pages = {357-363}, keywords = {optical coherence tomography, tunable lasers, Fourier domain mode locking, optical frequency domain imaging}, doi = {https://doi.org/10.1002/jbio.200910028}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.200910028}, eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/jbio.200910028}, abstract = {Abstract We report on recent progress in Fourier domain mode-locking (FDML) technology. The paper focuses on developments beyond pushing the speed of these laser sources. After an overview of improvements to FDML over the last three years, a brief analysis of OCT imaging using FDML lasers with different wavelengths is presented. For the first time, high speed, high quality FDML imaging at 1550 nm is presented and compared to a system at 1310 nm. The imaging results of human skin for both wavelengths are compared and analyzed. Sample arm optics, power on the sample, heterodyne gain, detection bandwidth, colour cut levels and sample location have been identical to identify the influence of difference in scattering and water absorption. The imaging performance at 1310 nm in human skin is only slightly better and the results suggest that water absorption only marginally affects the penetration depth in human skin at 1550 nm. For several applications this wavelength may be preferred. (© 2009 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim)}, year = {2009} } |
B.
Biedermann,
W.
Wieser,
C.
Eigenwillig,
T.
Klein, and
R.
Huber,
Dispersion, coherence and noise of Fourier Domain Mode Locked (FDML) lasers, in CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference , IEEE, 062009. pp. 1-1.
Dispersion, coherence and noise of Fourier Domain Mode Locked (FDML) lasers, in CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference , IEEE, 062009. pp. 1-1.
DOI: | 10.1109/CLEOE-EQEC.2009.5192900 |
Bibtex: | @INPROCEEDINGS{5192900, author={Biedermann, Benjamin R. and Wieser, Wolfgang and Eigenwillig, Christoph M. and Klein, Thomas and Huber, Robert}, booktitle={CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference}, title={Dispersion, coherence and noise of Fourier Domain Mode Locked (FDML) lasers}, year={2009}, volume={}, number={}, pages={1-1}, abstract={We present a detailed analysis of coherence and noise of the FDML laser, depending on filter drive frequency, detuning and amount of cavity dispersion. The results provide insight into phase and amplitude noise of the laser light itself. We address the following two questions: (1) How much dispersion compensation is necessary for optimum laser performance in FDML for a certain width of the optical band pass filter? (2) How are timing mismatch effects, caused by either detuning of the drive frequency or chromatic dispersion in the cavity of the filter, related to coherence length and noise?}, keywords={}, doi={10.1109/CLEOE-EQEC.2009.5192900}, ISSN={}, month={June},} |
R. Huber,
State-of-the-art and future of ultrahigh speed OCT, in CLEO/Europe and EQEC 2009 Conference Digest , Optica Publishing Group, 062009. pp. JTuA_3.
State-of-the-art and future of ultrahigh speed OCT, in CLEO/Europe and EQEC 2009 Conference Digest , Optica Publishing Group, 062009. pp. JTuA_3.
DOI: | 10.1109/CLEOE-EQEC.2009.5191695 |
Bibtex: | @INPROCEEDINGS{5191695, author={Huber, Robert}, booktitle={CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference}, title={State-of-the-art and future of ultrahigh speed OCT}, year={2009}, volume={}, number={}, pages={1-1}, abstract={This paper reviews the current status of high speed OCT systems on the different levels of development: commercial, laboratory prototype style and proof of concept type systems. The pro and contra of SD-OCT and SS-OCT are discussed and an analysis of the desired optimum imaging speeds for various applications. SS-OCT systems are used for imaging in highly scattering tissue ~1300 nm, a line rate of 60 MHz was achieved by with SD-OCT.}, keywords={}, doi={10.1109/CLEOE-EQEC.2009.5191695}, ISSN={}, month={June},} |
B.
Biedermann,
W.
Wieser,
C.
Eigenwillig,
T.
Klein, and
R.
Huber,
Dispersion, coherence and noise of Fourier domain mode locked lasers, Opt. Express , vol. 17, no. 12, pp. 9947-9961, 05 2009. Optica Publishing Group.
Dispersion, coherence and noise of Fourier domain mode locked lasers, Opt. Express , vol. 17, no. 12, pp. 9947-9961, 05 2009. Optica Publishing Group.
DOI: | 10.1364/OE.17.009947 |
Bibtex: | @article{Biedermann:09, author = {Benjamin R. Biedermann and Wolfgang Wieser and Christoph M. Eigenwillig and Thomas Klein and Robert Huber}, journal = {Opt. Express}, keywords = {Noise in imaging systems; Optical coherence tomography; Interferometry; Lasers, tunable; Optical coherence tomography; Dispersion; Laser light; Laser modes; Laser operation; Laser sources; Mode locking; Swept lasers}, number = {12}, pages = {9947--9961}, publisher = {Optica Publishing Group}, title = {Dispersion, coherence and noise of Fourier domain mode locked lasers}, volume = {17}, month = {Jun}, year = {2009}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-17-12-9947}, doi = {10.1364/OE.17.009947}, abstract = {We report on the effect of chromatic dispersion on coherence length and noise of Fourier Domain Mode Locked (FDML) lasers. An FDML laser with a sweep range of 100nm around 1550nm has been investigated. Cavity configurations with and without dispersion compensation have been analyzed using different widths of the intra-cavity optical band-pass filter. The measurements are compared to non-FDML wavelength swept laser sources. Based on these observations, a simple model is developed providing a connection between timing, photon cavity lifetime and characteristic time constant of the filter. In an optimized configuration, an instantaneous laser linewidth of 20pm is observed, corresponding to a 10{\texttimes} narrowing compared to the intra-cavity optical band-pass filter. A relative intensity noise of -133dBc/Hz or 0.2\% at 100MHz detection bandwidth during sweep operation is observed. For optimum operation, the filter drive frequency has to be set within 2ppm or 120mHz at 51kHz.}, } |
T.
Klein,
W.
Wieser,
B.
Biedermann,
C.
Eigenwillig,
G.
Palte, and
R.
Huber,
Raman pumped Fourier Domain Mode Locked (FDML) laser: Analysis of operation and application for optical coherence tomography (OCT), in CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference , IEEE, 052009. pp. 1-1.
Raman pumped Fourier Domain Mode Locked (FDML) laser: Analysis of operation and application for optical coherence tomography (OCT), in CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference , IEEE, 052009. pp. 1-1.
DOI: | 10.1109/CLEOE-EQEC.2009.5194704 |
Bibtex: | @INPROCEEDINGS{5194704, author={Klein, Thomas and Wieser, Wolfgang and Biedermann, Benjamin R. and Eigenwillig, Christoph M. and Palte, Gesa and Huber, Robert}, booktitle={CLEO/Europe - EQEC 2009 - European Conference on Lasers and Electro-Optics and the European Quantum Electronics Conference}, title={Raman pumped Fourier Domain Mode Locked (FDML) laser: Analysis of operation and application for optical coherence tomography (OCT)}, year={2009}, volume={}, number={}, pages={1-1}, abstract={limitations of the sweep repetition rate of rapidly wavelength swept laser sources. Such sources can be applied for optical coherence tomography (OCT) using frequency domain detection. This technique is called swept source OCT (ss-OCT) or optical frequency domain imaging (OFDI). FDML lasers usually consist of a semiconductor optical amplifier (SOA) as laser gain medium, an output coupler, a periodically driven optical band-pass filter (FFP-TF) and an optical delay line, so that their total length is typically several kilometres.}, keywords={}, doi={10.1109/CLEOE-EQEC.2009.5194704}, ISSN={}, month={June},} |
C.
Eigenwillig,
W.
Wieser,
B.
Biedermann, and
R.
Huber,
Subharmonic Fourier domain mode locking, Opt. Lett. , vol. 34, no. 6, pp. 725-727, 03 2009. Optica Publishing Group.
Subharmonic Fourier domain mode locking, Opt. Lett. , vol. 34, no. 6, pp. 725-727, 03 2009. Optica Publishing Group.
DOI: | 10.1364/OL.34.000725 |
Bibtex: | @article{Eigenwillig:09, author = {Christoph M. Eigenwillig and Wolfgang Wieser and Benjamin R. Biedermann and Robert Huber}, journal = {Opt. Lett.}, keywords = {Coherence imaging; Optical coherence tomography; Three-dimensional image acquisition; Lasers, tunable; Medical and biological imaging; Optical coherence tomography; Fourier domain mode locking; Laser operation; Laser sources; Laser systems; Mode locking; Optical coherence tomography}, number = {6}, pages = {725--727}, publisher = {Optica Publishing Group}, title = {Subharmonic Fourier domain mode locking}, volume = {34}, month = {Mar}, year = {2009}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-34-6-725}, doi = {10.1364/OL.34.000725}, abstract = {We demonstrate a subharmonically Fourier domain mode-locked wavelength-swept laser source with a substantially reduced cavity fiber length. In contrast to a standard Fourier domain mode-locked configuration, light is recirculated repetitively in the delay line with the optical bandpass filter used as switch. The laser has a fundamental optical round trip frequency of 285 kHz and can be operated at integer fractions thereof (subharmonics). Sweep ranges up to 95 nm full width centred at 1317 nm are achieved at the 1/5th subharmonic. A maximum sensitivity of 116 dB and an axial resolution of 12 $\mu$m in air are measured at an average sweep power of 12 mW. A sensitivity roll-off of 11 dB over 4 mm and 25 dB over 10 mm is observed and optical coherence tomography imaging is demonstrated. Besides the advantage of a reduced fiber length, subharmonic Fourier domain mode locking (shFDML) enables simple scaling of the sweep speed by extracting light from the delay part of the resonator. A sweep rate of 570 kHz is achieved. Characteristic features of shFDML operation, such as power leakage during fly-back and cw breakthrough, are investigated.}, } |
K.
Karnowski,
M.
Gora,
B.
Kaluzny,
R.
Huber,
M.
Szkulmowski,
A.
Kowalczyk, and
M.
Wojtkowski,
Swept source OCT imaging of human anterior segment at 200 kHz, in Ophthalmic Technologies XIX , Fabrice Manns and Per G. Söderberg and Arthur Ho, Eds. SPIE, 022009. pp. 716308.
Swept source OCT imaging of human anterior segment at 200 kHz, in Ophthalmic Technologies XIX , Fabrice Manns and Per G. Söderberg and Arthur Ho, Eds. SPIE, 022009. pp. 716308.
DOI: | 10.1117/12.808555 |
Bibtex: | @inproceedings{10.1117/12.808555, author = {Karol Karnowski and Michalina Gora and Bartlomiej Kaluzny and Robert Huber and Maciej Szkulmowski and Andrzej Kowalczyk and Maciej Wojtkowski}, title = {{Swept source OCT imaging of human anterior segment at 200 kHz}}, volume = {7163}, booktitle = {Ophthalmic Technologies XIX}, editor = {Fabrice Manns and Per G. S{\"o}derberg and Arthur Ho}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {716308}, abstract = {We present applicability of the high speed swept-source optical coherence tomography for in vivo imaging of the anterior segment of the human eye. Three dimensional imaging of the cornea with reduced motion artifacts is possible by using swept source with Fourier domain mode locking operating at 200kHz with 1300nm central wavelength. High imaging speeds allow for assessment of anterior and posterior corneal topography and generation of thickness and elevation maps.}, keywords = {Optical Coherence Tomography, Fourier domain detection methods, swept source OCT, anterior segment of the eye}, year = {2009}, doi = {10.1117/12.808555}, URL = {https://doi.org/10.1117/12.808555} } |
R. Huber,
Fourier domain mode locking: new lasers for optical coherence tomography, 02 2009. Online: SPIE.
Fourier domain mode locking: new lasers for optical coherence tomography, 02 2009. Online: SPIE.
DOI: | 10.1117/2.1200901.1440 |
Bibtex: | @Misc{HU_2009_Huber_b, Title = {{Fourier domain mode locking: new lasers for optical coherence tomography}}, Author = {Huber, Robert}, Year = {2009}, Booktitle = {SPIE Newsroom}, Doi = {10.1117/2.1200901.1440}, ISSN = {18182259}, keywords = {AG-Huber_FDML, AG-Huber_OCT}, Url = {http://www.spie.org/x33321.xml} } |
C.
Framme,
A.
Walter,
P.
Prahs,
R.
Regler, and
C.
Alt,
Structural changes of the retina after conventional laser photocoagulation and selective retina treatment (SRT) in spectral domain OCT, Curr Eye Res , vol. 34, no. 7, pp. 568-79, 2009.
Structural changes of the retina after conventional laser photocoagulation and selective retina treatment (SRT) in spectral domain OCT, Curr Eye Res , vol. 34, no. 7, pp. 568-79, 2009.
Übersicht der apparativen Entwicklungen in der optischen Kohärenztomografie: von der Darstellung der Retina zur Unterstützung therapeutischer Eingriffe. Optical Coherence Tomography: from Retina Imaging to Intraoperative Use- a Review, Klinische Monatsblätter für Augenheilkunde , vol. 226, no. 12, pp. 958, 2009.
Y.
Miura, and
J.
Roider,
Triamcinolone acetonide prevents oxidative stress-induced tight junction disruption of retinal pigment epithelial cells, Graefes Arch Clin Exp Ophthalmol , vol. 247, no. 5, pp. 641-9, 2009.
Triamcinolone acetonide prevents oxidative stress-induced tight junction disruption of retinal pigment epithelial cells, Graefes Arch Clin Exp Ophthalmol , vol. 247, no. 5, pp. 641-9, 2009.
DOI: | 10.1007/s00417-009-1041-6 |
Bibtex: | @article{Miura2009, author = {Miura, Y. and Roider, J.}, title = {Triamcinolone acetonide prevents oxidative stress-induced tight junction disruption of retinal pigment epithelial cells}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {247}, number = {5}, pages = {641-9}, note = {Using Smart Source Parsing May; Epub 2009 Feb 3}, abstract = {PURPOSE: Oxidative stress is known to disrupt the integrity of retinal pigment epithelium (RPE) tight junctions. The goal of this study is to evaluate the effect of triamcinolone acetonide (TA) on the junctional integrity of RPE under oxidative stress and to identify the underlying mechanisms. METHODS: Second passage porcine RPE cells were cultured on 6-well membrane inserts until 4 weeks after reaching confluence. Cells were incubated with TA (10(-5) M) for 30 min. FITC-containing medium was added to the upper chamber (cell's apical side). The cells were then challenged with 1 mM Hydrogen Peroxide (H(2)O(2)). After 5 h, the fluorescence intensity of the medium from lower chamber (cell's basolateral side) was measured using a fluorescence spectrofluorophotometer. This transepithelial flux of FITC-dextran was measured until the 21st day. The immunolocalization of occludin and F-actin was examined with fluorescence microscope. Reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio was determined by a colorimetric assay kit. RESULTS: Non-lethal oxidative stress by H(2)O(2) increased transepithelial flux of FITC-dextran significantly. TA inhibited this increase and preserved the lower flux through the whole experimental period. This permeability change by H(2)O(2) was reversible and recovered to the normal level within 3 weeks. In immunohistological study, H(2)O(2) reduced linear occludin staining at the cell border and increased actin stress fibers. TA prevented H(2)O(2)-induced disruption of junctional assembly of occludin and F-actin. Glutathione assay demonstrated that intracellular GSH/GSSG ratio decreased significantly with H(2)O(2), while TA preserved this ratio by up-regulating GSH synthesis. CONCLUSIONS: TA has a protective effect against oxidative stress-induced disruption of RPE tight junction by preserving cellular redox state.}, year = {2009} } |
T.
Just,
E.
Lankenau, and
H.
Pau,
Optische Kohärenztomographie in der Mittelohrchirurgie, HNO , vol. 57, no. 5, pp. 421-427, 2009.
Optische Kohärenztomographie in der Mittelohrchirurgie, HNO , vol. 57, no. 5, pp. 421-427, 2009.
E.
Lankenau,
C.
Schulz-Wackerbarth,
M.
Müller, and
P.
Steven,
Optical Coherence Tomography: from Retina Imaging to Intraoperative Use - a Review, Klinische Monatsblatter Fur Augenheilkunde , vol. 226, no. 12, pp. 958-964, 2009.
Optical Coherence Tomography: from Retina Imaging to Intraoperative Use - a Review, Klinische Monatsblatter Fur Augenheilkunde , vol. 226, no. 12, pp. 958-964, 2009.
DOI: | DOI 10.1055/s-0028-1109939 |
File: | WOS:000273527800005 |
Bibtex: | @article{Hüttmann2009, author = {Huttmann, G. and Lankenau, E. and Schulz-Wackerbarth, C. and Muller, M. and Steven, P. and Birngruber, R.}, title = {Optical Coherence Tomography: from Retina Imaging to Intraoperative Use - a Review}, journal = {Klinische Monatsblatter Fur Augenheilkunde}, volume = {226}, number = {12}, pages = {958-964}, note = {542VT Times Cited:6 Cited References Count:48}, abstract = {Background: Optical coherence tomography (OCT) is new diagnostic procedure that has rapidly evolved in the last years. The recently developed spectral domain OCT allows one to increase the imaging speed by a hundred times compared to the first generation time domain OCT and enables three-dimensional imaging as well as real-time imaging of fast moving structures. Volumetric imaging improves the quantitative measurement of morphology and the evaluation of temporal changes. In addition, an exact correlation with images acquired with other imaging modalities is possible. Real-time imaging enables also the use of OCT during examinations with the slit-lamp and during ophthalmological surgery. Methods: A spectral domain OCT was adapted to a slit lamp. 70 patients (91 eyes) were examined at the anterior or posterior segment of the eye. Images of healthy structures and different pathologies were compared to OCT images obtained with Stratus 3, Spectralis, and the SL-OCT. To demonstrate the feasibility of OCT during surgery, spectral domain OCT devices working with 20000 and 210000 A scans per second were coupled by specially developed optics to the camera port of a surgical microscope. The device was tested with phantoms and enucleated pig eyes. Results and Conclusions: A5 kHz spectral domain OCT can image the retina during slit lamp-based indirect ophthalmoscopy with a quality similar to that of the Stratus 3. In addition, relevant structures of the anterior segment were imaged. Here, compared to commercially available devices, the imaged field was smaller and the angle of the anterior chamber was not directly visible due to the 830 nm wavelength, which had to be used for retinal imaging. Through the surgical microscope, a volumetric imaging of epithelium, Bowman's, Descemet's membranes, limbus, iris, lens, conjunctiva and sclera was demonstra-ted with several tens of centimetre working distance. Instruments and incisions in the cornea were visualised with 20 mu m precision. Real-time imaging and visualisation of volumetric OCT data were also demonstrated. In principle, all technical problems of an intraoperative use of OCT have been solved and a clinical trial will start in the near future. OCT has the potential to improve the precision of surgical interventions and may even enable new interventions.}, keywords = {physiological optics cornea anatomy in-vivo ultrahigh-resolution anterior segment time-domain blood-flow eye surgery oct cyclophotocoagulation cornea}, ISSN = {0023-2165}, DOI = {DOI 10.1055/s-0028-1109939}, url = {<Go to ISI>://WOS:000273527800005}, year = {2009}, type = {Journal Article} } |
T.
Just,
E
Lankenau, and
H.
Pau,
Optical coherence tomography of the oval window niche., J Laryngol Oto , vol. 1, pp. 1-6, 2009.
Optical coherence tomography of the oval window niche., J Laryngol Oto , vol. 1, pp. 1-6, 2009.
S.
Tiede,
N.
Koop,
J.
Kloepper,
R.
Fassler, and
R.
Paus,
Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells, Stem Cells , vol. 27, no. 11, pp. 2793-803, 2009.
Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells, Stem Cells , vol. 27, no. 11, pp. 2793-803, 2009.
DOI: | 10.1002/stem.213 |
Bibtex: | @article{Tiede2009, author = {Tiede, S. and Koop, N. and Kloepper, J. E. and Fassler, R. and Paus, R.}, title = {Nonviral in situ green fluorescent protein labeling and culture of primary, adult human hair follicle epithelial progenitor cells}, journal = {Stem Cells}, volume = {27}, number = {11}, pages = {2793-803}, ISSN = {1066-5099}, DOI = {10.1002/stem.213}, year = {2009}, type = {Journal Article} } |
P.
Steven,
M.
Müller,
N.
Koop, and
C.
Rose,
Comparison of Cornea Module and DermaInspect for noninvasive imaging of ocular surface pathologies, Journal of Biomedical Optics , vol. 14, no. 6, pp. 064040-064040, 2009.
Comparison of Cornea Module and DermaInspect for noninvasive imaging of ocular surface pathologies, Journal of Biomedical Optics , vol. 14, no. 6, pp. 064040-064040, 2009.
S.
Kandelhardt,
J.
Leppert,
J.
Kandelhardt,
E.
Reusche, and
A.
Giese,
Multi-photon excitation fluorescence microscopy of brain-tumour tissue and analysis of cell density, Acta Neurochir , vol. 151, pp. 253-262, 2009.
Multi-photon excitation fluorescence microscopy of brain-tumour tissue and analysis of cell density, Acta Neurochir , vol. 151, pp. 253-262, 2009.
K
Schlott,
K
Hausmann,
S
Koinzer,
L
Ptaszynski, and
J
Roider,
Dependence of optoacoustic transients on exciting laser parameters for real-time monitoring of retinal photocoagulation, 2009. pp. 73730K-73730K.
Dependence of optoacoustic transients on exciting laser parameters for real-time monitoring of retinal photocoagulation, 2009. pp. 73730K-73730K.
File: | 12.831913 |
Bibtex: | @inproceedings{Langejürgen2009, author = {Langejürgen, J and Schlott, K and Bever, M and Hausmann, K and Koinzer, S and Ptaszynski, L and Roider, J and Birngruber, R and Brinkmann, R}, title = {Dependence of optoacoustic transients on exciting laser parameters for real-time monitoring of retinal photocoagulation}, pages = {73730K-73730K}, note = {10.1117/12.831913}, abstract = {The extent of retinal laser coagulations depends on the temperature increase at the fundus and the time of irradiation. Due to light scattering within the eye and variable fundus pigmentation the induced temperature increase and therefore the extent of the coagulations cannot be predicted solely from the laser parameters. We use optoacoustics to monitor the temperature rise in real-time in vivo (rabbit) and ex vivo (porcine eye) and to automatically control the coagulation strength. Continuous wave treatment laser radiation and pulsed probe laser light (1-1100 ns) are coupled into the same fibre and are imaged onto the retina by a laser slit lamp. The temperature dependent pressure waves are detected by an ultrasonic transducer embedded in a customary contact lens. Below the coagulation threshold the increase in acoustic amplitude due to thermal tissue expansion is up to 40 %. Best signal to noise ratios > 10 are achieved with probe pulse durations of 1 to 75 ns. Further a time critical algorithm is developed which automatically ceases laser treatment when a certain preset coagulation strength is achieved. Coagulations with similar extent are obtained with this method in vitro and in vivo even when varying the power of the treatment laser by 50 %. These preliminary results are very promising, thus this method might be suitable for an automatic feedback controlled photocoagulation with adjustable coagulation strength.}, url = {http://dx.doi.org/10.1117/12.831913}, type = {Conference Proceedings}, Year = { 2009} } |
S.
Freidank, and
N.
Linz,
Mit der biomedizinischen Optik hoch hinaus - Lübecker Projekt zur Laserforschung auf der Zugspitze , Focus Uni Luebeck / Universität Lübeck , vol. 26, no. 1, pp. 16, 2009.
Mit der biomedizinischen Optik hoch hinaus - Lübecker Projekt zur Laserforschung auf der Zugspitze , Focus Uni Luebeck / Universität Lübeck , vol. 26, no. 1, pp. 16, 2009.
A
Fritz,
L
Ptaszynski, and
H
Stoehr,
Dynamic of laser induced transient microbubble clusters, (BiOS), Conference on Biomedical Optics, Eds. Proc SPIE, 2009.
Dynamic of laser induced transient microbubble clusters, (BiOS), Conference on Biomedical Optics, Eds. Proc SPIE, 2009.
File: | abstract.cfm |
Bibtex: | @inproceedings{Fritz2009, author = {Fritz, A and Ptaszynski, L and Stoehr, H and Brinkmann, R}, title = {Dynamic of laser induced transient microbubble clusters}, editor = {(BiOS), Conference on Biomedical Optics}, publisher = {Proc SPIE}, type = {Conference Proceedings}, year = { 2009}, URL = { https://www.osapublishing.org/abstract.cfm?uri=ECBO-2009-7373_0D} } |
K.
Lachmann,
S.
Eckert,
A.
Vogel,
A.
Klinger,
A.
Gebert, and
C.
Klages,
Development of a multifunctional coating system for laser-induced material transport, Progress in Organic Coatings , vol. 64, no. 2–3, pp. 294-299, 2009.
Development of a multifunctional coating system for laser-induced material transport, Progress in Organic Coatings , vol. 64, no. 2–3, pp. 294-299, 2009.
D.
Hillmann, and
P.
Koch,
Using nonequispaced fast Fourier transformation to process optical coherence tomography signals, Peter, E. Andersen and Brett, E. Bouma, Eds. SPIE, 2009. pp. 73720R.
Using nonequispaced fast Fourier transformation to process optical coherence tomography signals, Peter, E. Andersen and Brett, E. Bouma, Eds. SPIE, 2009. pp. 73720R.
File: | ECBO.2009.7372_0R |
Bibtex: | @inproceedings{Hillmann, author = {Hillmann, Dierck and Huttmann, Gereon and Koch, Peter}, title = {Using nonequispaced fast Fourier transformation to process optical coherence tomography signals}, editor = {Peter, E. Andersen and Brett, E. Bouma}, publisher = {SPIE}, volume = {7372}, pages = {73720R}, url = { https://doi.org/10.1364/ECBO.2009.7372_0R}, year = { 2009} } |
T.
Just,
E
Lankenau, and
H.
Pau,
Intra-operative application of optical coherence tomography with an operating microscope., J Laryngol Otol , vol. 123, pp. 1027-1030, 2009.
Intra-operative application of optical coherence tomography with an operating microscope., J Laryngol Otol , vol. 123, pp. 1027-1030, 2009.
G.
Hüttmann,
C.
Yao,
X.
Qu,
Z.
Zhang, and
R.
Rahmanzadeh,
Influence of Laser Parameters on Membrane Permeability with Nanoparticles and Targeted Antibody Transfection, J Biomed Opt , vol. 14, pp. 054034, 2009.
Influence of Laser Parameters on Membrane Permeability with Nanoparticles and Targeted Antibody Transfection, J Biomed Opt , vol. 14, pp. 054034, 2009.
DOI: | 10.1117/1.3253320 |
Bibtex: | @article{Yao, author = {Yao, C and Qu, X. and Zhang, Z. and B., Yao and Hüttmann, G and Rahmanzadeh, R.}, title = {Influence of Laser Parameters on Membrane Permeability with Nanoparticles and Targeted Antibody Transfection}, journal = {J Biomed Opt}, volume = {14}, pages = {054034}, note = {Journal article}, year = {2009} } |
F.
Gasca,
L.
Ramrath,
G.
Huettmann, and
A.
Schweikard,
Automated segmentation of tissue structures in optical coherence tomography data, J Biomed Opt , vol. 14, no. 3, pp. 034046, 2009.
Automated segmentation of tissue structures in optical coherence tomography data, J Biomed Opt , vol. 14, no. 3, pp. 034046, 2009.
H.
Böhringer,
E.
Lankenau,
F.
Stellmacher,
E.
Reusche, and
A.
Giese,
Imaging of human brain tumor tissue by near-infrared laser coherence tomography, Acta Neurochir (Wien) , vol. 151, no. 5, pp. 507-17; discussion 517, 2009.
Imaging of human brain tumor tissue by near-infrared laser coherence tomography, Acta Neurochir (Wien) , vol. 151, no. 5, pp. 507-17; discussion 517, 2009.
K.
Schlott,
L.
Ptaszynski, and
S.
Koinzer,
Automatische Dosimetrie bei der Laserphotokoagulation der Netzhaut, 3. Dresdner Medizintechnik-Symposium mit DFG Forschungsschwerpunkt Protektive Beatmungskonzepte , vol. 10, 2009.
Automatische Dosimetrie bei der Laserphotokoagulation der Netzhaut, 3. Dresdner Medizintechnik-Symposium mit DFG Forschungsschwerpunkt Protektive Beatmungskonzepte , vol. 10, 2009.
C.
Framme, and
G.
Panagakis,
Effects on Choroidal Neovascularizations after Anti-VEGF Upload Using Intravitreal Ranibizumab as Determined by Spectral Domain Optical Coherence Tomography, Invest Ophthalmol Vis Sci , 2009.
Effects on Choroidal Neovascularizations after Anti-VEGF Upload Using Intravitreal Ranibizumab as Determined by Spectral Domain Optical Coherence Tomography, Invest Ophthalmol Vis Sci , 2009.
DOI: | iovs.09-4496 [pii] 10.1167/iovs.09-4496 |
File: | query.fcgi |
Bibtex: | @article{Framme2009, author = {Framme, C. and Panagakis, G. and Birngruber, R.}, title = {Effects on Choroidal Neovascularizations after Anti-VEGF Upload Using Intravitreal Ranibizumab as Determined by Spectral Domain Optical Coherence Tomography}, journal = {Invest Ophthalmol Vis Sci}, note = {Journal article Investigative ophthalmology & visual science Invest Ophthalmol Vis Sci. 2009 Oct 29.}, abstract = {Purpose: To image CNV structure before and after anti-VEGF treatment using spectral domain optical coherence tomography (SD-OCT). Material and methods: In 78 patients newly diagnosed CNVs (classic CNV: n=16; occult CNV: n=54; minimal classic CNV: n=8) due to AMD were imaged before and 4 weeks after anti-VEGF upload with 3 intravitreal injections of Ranibizumab. Qualitative (structural changes) and quantitative measurements (diameter and thickness) of the CNVs were obtained from the OCT images using the Heidelberg Eye Explorer software. Results: Classic CNV components were observed above the RPE/photoreceptor complex, whereas occult CNVs stayed below. Qualitatively, overall CNV architecture appeared to be unchanged in 78%, reduced in thickness in 18%, and became larger in 4%. Quantitatively, for all CNV subtypes the diameter of CNVs (preoperatively: 2813mum; postoperatively: 2804mum) did not change after treatment (classic CNVs: p=0.390; occult CNVs: p=0.405, minimal classic CNVs: p=0.092) independently of postoperative retinal edema. The overall thickness of the CNV; however, reduced from 205mum to 175mum (p=0,000). Thickness reduction was significantly enhanced especially in CNVs with classic components (n=24; 252mum to 197mum (p=0.000); reduction: 22%), whereas reduction was smaller but also significant in occult CNVs (183mum to 164mum (p=0.003); reduction: 10%). Conclusion: Using SD-OCT CNV size can be two-dimensionally determined and followed up after intravitreal anti-VEGF treatment. Quantitative measurements underlined stable CNV diameters for all subtypes but revealed significant reduction of thickness especially for classic CNV components. Thus, Ranibizumab monotherapy is able to morphologically stop further CNV growth but does not lead to a major regression of CNVs especially of its occult components.}, ISSN = {1552-5783 (Electronic) 0146-0404 (Linking)}, DOI = {iovs.09-4496 [pii] 10.1167/iovs.09-4496}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19875667}, year = {2009}, type = {Journal Article} } |
K.
Schlott,
J.
Langejürgen,
M.
Bever,
S.
Koinzer, and
R.
Brinkmann,
Time resolved detection of tissue denaturation during retinal photocoagulation, 7373, Proc. SPIE, Eds. 2009. pp. 73730E-73730E.
Time resolved detection of tissue denaturation during retinal photocoagulation, 7373, Proc. SPIE, Eds. 2009. pp. 73730E-73730E.
File: | 12.168030 |
Bibtex: | @inproceedings{Schlott2009, author = {Schlott, Kerstin and Langejürgen, Jens and Bever, Marco and Koinzer, Stefan and Birngruber, Reginald and Brinkmann, Ralf}, title = {Time resolved detection of tissue denaturation during retinal photocoagulation}, editor = {7373, Proc. SPIE}, pages = {73730E-73730E}, note = {10.1117/12.831877}, abstract = {The retinal photocoagulation is an established treatment method for different retinal diseases. The extent of the thermal coagulations depends strongly on the generated temperature increase. Until now the dosage is based on a pool of experience of the treating physicians as well as the appearance of the whitish lesions on the retina. The temperature course during photocoagulation can be measured in real-time by optoacoustics. A frequency-doubled Q-switched Nd:YLF laser (523nm, 75 ns) is used for optoacoustic excitation and a continuous-wave Nd:YAG laser (532nm) with adjustable irradiation time and power for heating of the fundus tissue. The onset of coagulation is determined by a photodiode that is placed directly behind enucleated porcine eyes, which served as a model. The onset of coagulation is observed clearly when scattering sets in. The required power for coagulation increases exponentially with decreasing irradiation time. The first results on rabbit eyes in vivo indicate that the onset of coagulation defined by just barely visibile lesions at a slit lamp sets in at an ED50 threshold temperature of 63°C for an irradiation time of 400 ms. In conclusion, optoacoustics can be used to determine temperatures during retinal laser treatments in real-time. This allows evaluating the time-temperature-dependence of retinal coagulation in vivo.}, keywords = {AutoPhoN}, url = {http://dx.doi.org/10.1117/12.831877}, type = {Conference Proceedings}, year = { 2009}, url = { https://doi.org/10.1117/12.168030} } |
2008
T.
Klein,
W.
Wieser,
B.
Biedermann,
C.
Eigenwillig,
G.
Palte, and
R.
Huber,
Raman-pumped Fourier-domain mode-locked laser: analysis of operation and application for optical coherence tomography, Opt. Lett. , vol. 33, no. 23, pp. 2815-2817, Dec. 2008. Optica Publishing Group.
Raman-pumped Fourier-domain mode-locked laser: analysis of operation and application for optical coherence tomography, Opt. Lett. , vol. 33, no. 23, pp. 2815-2817, Dec. 2008. Optica Publishing Group.
DOI: | 10.1364/OL.33.002815 |
Bibtex: | @article{Klein:08, author = {Thomas Klein and Wolfgang Wieser and Benjamin R. Biedermann and Christoph M. Eigenwillig and Gesa Palte and Robert Huber}, journal = {Opt. Lett.}, keywords = {Optical coherence tomography; Lasers, fiber; Lasers, Raman; Lasers, tunable; Optical coherence tomography; Laser operation; Mode locking; Optical coherence tomography; Optical components; Raman fiber lasers; Semiconductor lasers}, number = {23}, pages = {2815--2817}, publisher = {Optica Publishing Group}, title = {Raman-pumped Fourier-domain mode-locked laser: analysis of operation and application for optical coherence tomography}, volume = {33}, month = {Dec}, year = {2008}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-33-23-2815}, doi = {10.1364/OL.33.002815}, abstract = {We demonstrate a Raman-pumped Fourier-domain mode-locked (FDML) fiber laser and optical coherence tomography imaging with this source. The wavelength sweep range of only 30 nm centered around 1550 nm results in limited axial resolution, hence a nonbiological sample is imaged. An output power of 1.9 mW was achieved at a sweep rate of 66 kHz and a maximum ranging depth of ~2.5 cm. Roll-off characteristics are found to be similar to FDML lasers with semiconductor optical amplifiers as gain media. The application of Raman gain also enables unperturbed cavity ring-down experiments in FDML lasers for the first time, providing direct access to the photon lifetime in the laser cavity. Good agreement with nonswept cw operation is proof of the stationary operation of FDML lasers.}, } |
V.
Srinivasan,
D.
Adler,
Y.
Chen,
I.
Gorczynska,
R.
Huber,
J.
Duker,
J.
Schuman, and
J.
Fujimoto,
Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head., Investigative Ophthalmology & Visual Science , vol. 49, no. 11, pp. 5103-5110, Nov. 2008.
Ultrahigh-speed optical coherence tomography for three-dimensional and en face imaging of the retina and optic nerve head., Investigative Ophthalmology & Visual Science , vol. 49, no. 11, pp. 5103-5110, Nov. 2008.
DOI: | 10.1167/iovs.08-2127 |
Bibtex: | @article{10.1167/iovs.08-2127, author = {Srinivasan, Vivek J. and Adler, Desmond C. and Chen, Yueli and Gorczynska, Iwona and Huber, Robert and Duker, Jay S. and Schuman, Joel S. and Fujimoto, James G.}, title = "{Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head}", journal = {Investigative Ophthalmology & Visual Science}, volume = {49}, number = {11}, pages = {5103-5110}, year = {2008}, month = {11}, abstract = "{ purpose. To demonstrate ultrahigh-speed optical coherence tomography (OCT) imaging of the retina and optic nerve head at 249,000 axial scans per second and a wavelength of 1060 nm. To investigate methods for visualization of the retina, choroid, and optic nerve using high-density sampling enabled by improved imaging speed. methods. A swept-source OCT retinal imaging system operating at a speed of 249,000 axial scans per second was developed. Imaging of the retina, choroid, and optic nerve were performed. Display methods such as speckle reduction, slicing along arbitrary planes, en face visualization of reflectance from specific retinal layers, and image compounding were investigated. results. High-definition and three-dimensional (3D) imaging of the normal retina and optic nerve head were performed. Increased light penetration at 1060 nm enabled improved visualization of the choroid, lamina cribrosa, and sclera. OCT fundus images and 3D visualizations were generated with higher pixel density and less motion artifacts than standard spectral/Fourier domain OCT. En face images enabled visualization of the porous structure of the lamina cribrosa, nerve fiber layer, choroid, photoreceptors, RPE, and capillaries of the inner retina. conclusions. Ultrahigh-speed OCT imaging of the retina and optic nerve head at 249,000 axial scans per second is possible. The improvement of ∼5 to 10× in imaging speed over commercial spectral/Fourier domain OCT technology enables higher density raster scan protocols and improved performance of en face visualization methods. The combination of the longer wavelength and ultrahigh imaging speed enables excellent visualization of the choroid, sclera, and lamina cribrosa. }", issn = {1552-5783}, doi = {10.1167/iovs.08-2127}, url = {https://doi.org/10.1167/iovs.08-2127}, eprint = {https://arvojournals.org/arvo/content\_public/journal/iovs/932946/z7g01108005103.pdf}, } |
B.
Biedermann,
W.
Wieser,
C.
Eigenwillig,
G.
Palte,
D.
Adler,
V.
Srinivasan,
J.
Fujimoto, and
R.
Huber,
Real time en face Fourier-domain optical coherence tomography with direct hardware frequency demodulation, Opt. Lett. , vol. 33, no. 21, pp. 2556-2558, Oct. 2008. Optica Publishing Group.
Real time en face Fourier-domain optical coherence tomography with direct hardware frequency demodulation, Opt. Lett. , vol. 33, no. 21, pp. 2556-2558, Oct. 2008. Optica Publishing Group.
DOI: | 10.1364/OL.33.002556 |
Bibtex: | @article{Biedermann:08, author = {Benjamin R. Biedermann and Wolfgang Wieser and Christoph M. Eigenwillig and Gesa Palte and Desmond C. Adler and Vivek J. Srinivasan and James G. Fujimoto and Robert Huber}, journal = {Opt. Lett.}, keywords = {Coherence imaging; Optical coherence tomography; Three-dimensional image acquisition; Lasers, tunable; Medical and biological imaging; Optical coherence tomography; Analog to digital converters; Interference; Laser sources; Medical imaging; Mode locking; Optical coherence tomography}, number = {21}, pages = {2556--2558}, publisher = {Optica Publishing Group}, title = {Real time en face Fourier-domain optical coherence tomography with direct hardware frequency demodulation}, volume = {33}, month = {Nov}, year = {2008}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-33-21-2556}, doi = {10.1364/OL.33.002556}, abstract = {We demonstrate en face swept source optical coherence tomography (ss-OCT) without requiring a Fourier transformation step. The electronic optical coherence tomography (OCT) interference signal from a k-space linear Fourier domain mode-locked laser is mixed with an adjustable local oscillator, yielding the analytic reflectance signal from one image depth for each frequency sweep of the laser. Furthermore, a method for arbitrarily shaping the spectral intensity profile of the laser is presented, without requiring the step of numerical apodization. In combination, these two techniques enable sampling of the in-phase and quadrature signal with a slow analog-to-digital converter and allow for real-time display of en face projections even for highest axial scan rates. Image data generated with this technique is compared to en face images extracted from a three-dimensional OCT data set. This technique can allow for real-time visualization of arbitrarily oriented en face planes for the purpose of alignment, registration, or operator-guided survey scans while simultaneously maintaining the full capability of high-speed volumetric ss-OCT functionality.}, } |
C.
Eigenwillig,
B.
Biedermann,
G.
Palte, and
R.
Huber,
K-space linear Fourier domain mode locked laser and applications for optical coherence tomography, Opt. Express , vol. 16, no. 12, pp. 8916-8937, 06 2008. Optica Publishing Group.
K-space linear Fourier domain mode locked laser and applications for optical coherence tomography, Opt. Express , vol. 16, no. 12, pp. 8916-8937, 06 2008. Optica Publishing Group.
DOI: | 10.1364/OE.16.008916 |
Bibtex: | @article{Eigenwillig:08, author = {Christoph M. Eigenwillig and Benjamin R. Biedermann and Gesa Palte and Robert Huber}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Three-dimensional image acquisition; Interferometry; Lasers, tunable; Medical and biological imaging; Optical coherence tomography; Image quality; Laser modes; Laser sources; Medical imaging; Mode locking; Swept lasers}, number = {12}, pages = {8916--8937}, publisher = {Optica Publishing Group}, title = {K-space linear Fourier domain mode locked laser and applications for optical coherence tomography}, volume = {16}, month = {Jun}, year = {2008}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-16-12-8916}, doi = {10.1364/OE.16.008916}, abstract = {We report on a Fourier Domain Mode Locked (FDML) wavelength swept laser source with a highly linear time-frequency sweep characteristic and demonstrate OCT imaging without k-space resampling prior to Fourier transformation. A detailed theoretical framework is provided and different strategies how to determine the optimum drive waveform of the piezo-electrically actuated optical bandpass-filter in the FDML laser are discussed. An FDML laser with a relative optical frequency deviation $\Delta$$\nu$/$\nu$ smaller than 8{\textperiodcentered}10-5 over a 100 nm spectral bandwidth at 1300 nm is presented, enabling high resolution OCT over long ranging depths. Without numerical time-to-frequency resampling and without spectral apodization a sensitivity roll off of 4 dB over 2 mm, 12.5 dB over 4 mm and 26.5 dB over 1 cm at 3.5 {\textmu}s sweep duration and 106.6 dB maximum sensitivity at 9.2 mW average power is achieved. The axial resolution in air degrades from 14 to 21 {\textmu}m over 4 mm imaging depth. The compensation of unbalanced dispersion in the OCT sample arm by an adapted tuning characteristic of the source is demonstrated. Good stability of the system without feedback-control loops is observed over hours.}, } |
C.
Jirauschek,
C.
Eigenwillig,
B.
Biedermann, and
R.
Huber,
Fourier domain mode locking theory, in 2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science , IEEE, 052008. pp. 1-2.
Fourier domain mode locking theory, in 2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science , IEEE, 052008. pp. 1-2.
DOI: | 10.1109/CLEO.2008.4551638 |
Bibtex: | @INPROCEEDINGS{4571888, author={Jirauschek, Christian and Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert}, booktitle={2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science}, title={Fourier domain mode locking theory}, year={2008}, volume={}, number={}, pages={1-2}, abstract={We present a theoretical model for the recently developed Fourier domain mode locked (FDML) lasers. The good agreement with experiment provides valuable insights into the mechanism of FDML operation.}, keywords={}, doi={10.1109/CLEO.2008.4551638}, ISSN={}, month={May},} |
C.
Eigenwillig,
B.
Biedermann, and
R.
Huber,
Optical coherence tomography imaging with k-space linear Fourier Domain Mode Locked lasers, in 2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science , IEEE, 052008. pp. 1-2.
Optical coherence tomography imaging with k-space linear Fourier Domain Mode Locked lasers, in 2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science , IEEE, 052008. pp. 1-2.
DOI: | 10.1109/CLEO.2008.4551011 |
Bibtex: | @INPROCEEDINGS{4571261, author={Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert}, booktitle={2008 Conference on Lasers and Electro-Optics and 2008 Conference on Quantum Electronics and Laser Science}, title={Optical coherence tomography imaging with k-space linear fourier domain mode locked lasers}, year={2008}, volume={}, number={}, pages={1-2}, abstract={We report on a Fourier Domain Mode Locked wavelength swept laser source with a highly linear time-frequency sweep characteristic and demonstrate OCT imaging without k-space resampling prior to Fourier transformation with this source.}, keywords={}, doi={10.1109/CLEO.2008.4551011}, ISSN={}, month={May},} |
P.
Andrews,
Y.
Chen,
M.
Onozato,
S.
Huang,
D.
Adler,
R.
Huber,
J.
Jiang,
S.
Barry,
A.
Cable, and
J.
Fujimoto,
High-resolution optical coherence tomography imaging of the living kidney, Laboratory Investigation , vol. 88, no. 4, pp. 441-449, 04 2008.
High-resolution optical coherence tomography imaging of the living kidney, Laboratory Investigation , vol. 88, no. 4, pp. 441-449, 04 2008.
DOI: | 10.1038/labinvest.2008.4 |
Bibtex: | @article{ANDREWS2008441, title = {High-resolution optical coherence tomography imaging of the living kidney}, journal = {Laboratory Investigation}, volume = {88}, number = {4}, pages = {441-449}, year = {2008}, issn = {0023-6837}, doi = {https://doi.org/10.1038/labinvest.2008.4}, url = {https://www.sciencedirect.com/science/article/pii/S0023683722019158}, author = {Peter M Andrews and Yu Chen and Maristela L Onozato and Shu-Wei Huang and Desmond C Adler and Robert A Huber and James Jiang and Scott E Barry and Alex E Cable and James G Fujimoto}, keywords = {ischemia, kidney, optical coherence tomography (OCT), renal pathology, three-dimensional imaging, renal transplantation}, abstract = {Optical coherence tomography (OCT) is a rapidly emerging imaging modality that can provide non-invasive, cross-sectional, high-resolution images of tissue morphology in situ and in real-time. In the present series of studies, we used a high-speed OCT imaging system equipped with a frequency-swept laser light source (1.3 μm wavelength) to study living kidneys in situ. Adult, male Munich–Wistar rats were anesthetized, a laparotomy was performed and the living kidneys were exposed for in situ observation. We observed the kidneys prior to, during and following exposure to renal ischemia induced by clamping the renal artery. The effects of intravenous mannitol infusion (1.0 ml of 25%) prior to and during renal ischemia were also studied. Finally, living kidneys were flushed with a renal preservation solution, excised and observed while being stored at 0–4°C. Three-dimensional OCT data sets enabled visualization of the morphology of the uriniferous tubules and the renal corpuscles. When renal ischemia was induced, OCT revealed dramatic shrinkage of tubular lumens due to swelling of the lining epithelium. Three-dimensional visualization and volumetric rendering software provided an accurate evaluation of volumetric changes in tubular lumens in response to renal ischemia. Observations of kidneys flushed with a renal preservation solution and stored at 0–4°C also revealed progressive and significant loss of tubular integrity over time. Intravenous infusion of mannitol solution resulted in thinning of the tubular walls and an increase in the tubular lumen diameters. Mannitol infusion also prevented the cell swelling that otherwise resulted in shrinkage of proximal tubule lumens during ischemia. We conclude that OCT represents an exciting new approach to visualize, in real-time, pathological changes in the living kidney in a non-invasive fashion. Possible clinical applications are discussed.} } |
D.
Adler,
Y.
Chen,
R.
Huber,
J.
Schmitt,
J.
Connolly, and
J.
Fujimoto,
In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 032008. pp. 684708.
In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII , Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin, Eds. SPIE, 032008. pp. 684708.
DOI: | 10.1117/12.761850 |
Bibtex: | @inproceedings{10.1117/12.761850, author = {Desmond C. Adler and Yu Chen and Robert Huber and Joseph Schmitt and James Connolly and James G. Fujimoto}, title = {{In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers}}, volume = {6847}, booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII}, editor = {Joseph A. Izatt and James G. Fujimoto and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {684708}, abstract = {We report an endoscopic optical coherence tomography (OCT) system based on a Fourier Domain Mode Locked (FDML) laser, a novel data acquisition (DAQ) system with optical frequency clocking, and a high-speed spiralscanning fiber probe. The system is capable of acquiring three-dimensional (3D) in vivo datasets at 100,000 axial lines/s and 50 frames/s, enabled by the high sweep rates of the FDML laser and the efficient data processing of the DAQ system. This high imaging rate allows densely-sampled 3D datasets to be acquired, giving a resolvable feature size of 9 &mgr;m x 20 &mgr;m x 7 &mgr;m (transverse x longitudinal x axial, XYZ). In vivo 3D endomicroscopy is demonstrated in the rabbit colon, where individual colonic crypts are clearly visualized and measured. With further improvements in DAQ technology, the imaging speed will be scalable to the hundreds of thousands of axial lines/s supported by FDML lasers.}, keywords = {Optical coherence tomography, Endoscopic microscopy, Fourier Domain Mode Locked lasers, FDML, Three dimensional microscopy, In vivo microscopy, Biomedical optics, Swept source optical coherence tomography}, year = {2008}, doi = {10.1117/12.761850}, URL = {https://doi.org/10.1117/12.761850} } |
T.
Bajraszewski,
M.
Wojtkowski,
M.
Szkulmowski,
A.
Szkulmowska,
R.
Huber, and
A.
Kowalczyk,
Improved spectral optical coherence tomography using optical frequency comb, Opt. Express , vol. 16, no. 6, pp. 4163-4176, 03 2008. Optica Publishing Group.
Improved spectral optical coherence tomography using optical frequency comb, Opt. Express , vol. 16, no. 6, pp. 4163-4176, 03 2008. Optica Publishing Group.
DOI: | 10.1364/OE.16.004163 |
Bibtex: | @article{Bajraszewski:08, author = {Tomasz Bajraszewski and Maciej Wojtkowski and Maciej Szkulmowski and Anna Szkulmowska and Robert Huber and Andrzej Kowalczyk}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Fabry-Perot; Image reconstruction techniques; Multiframe image processing ; Frequency combs; Medical imaging; Ophthalmic imaging; Optical coherence tomography; Swept sources; Three dimensional imaging}, number = {6}, pages = {4163--4176}, publisher = {Optica Publishing Group}, title = {Improved spectral optical coherence tomography using optical frequency comb}, volume = {16}, month = {Mar}, year = {2008}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-16-6-4163}, doi = {10.1364/OE.16.004163}, abstract = {We identify and analyze factors influencing sensitivity drop-off in Spectral OCT and propose a system employing an Optical Frequency Comb (OFC) to verify this analysis. Spectral Optical Coherence Tomography using a method based on an optical frequency comb is demonstrated. Since the spectrum sampling function is determined by the comb rather than detector pixel distribution, this method allows to overcome limitations of high resolution Fourier-domain OCT techniques. Additionally, the presented technique also enables increased imaging range while preserving high axial resolution. High resolution cross-sectional images of biological samples obtained with the proposed technique are presented.}, } |
D.
Adler,
S.
Huang,
R.
Huber, and
J.
Fujimoto,
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography, Opt. Express , vol. 16, no. 7, pp. 4376-4393, 03 2008. Optica Publishing Group.
Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography, Opt. Express , vol. 16, no. 7, pp. 4376-4393, 03 2008. Optica Publishing Group.
DOI: | 10.1364/OE.16.004376 |
Bibtex: | @article{Adler:08, author = {Desmond C. Adler and Shu-Wei Huang and Robert Huber and James G. Fujimoto}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Phase measurement; Lasers, tunable; Nanomaterials; Laser beams; Medical imaging; Multimode lasers; Optical Doppler tomography; Phase modulation; Single mode lasers}, number = {7}, pages = {4376--4393}, publisher = {Optica Publishing Group}, title = {Photothermal detection of gold nanoparticles using phase-sensitive optical coherence tomography}, volume = {16}, month = {Mar}, year = {2008}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-16-7-4376}, doi = {10.1364/OE.16.004376}, abstract = {The detection of a gold nanoparticle contrast agent is demonstrated using a photothermal modulation technique and phase sensitive optical coherence tomography (OCT). A focused beam from a laser diode at 808 nm is modulated at frequencies of 500 Hz--60 kHz while irradiating a solution containing nanoshells. Because the nanoshells are designed to have a high absorption coefficient at 808 nm, the laser beam induces small-scale localized temperature oscillations at the modulation frequency. These temperature oscillations result in optical path length changes that are detected by a phase-sensitive, swept source OCT system. The OCT system uses a double-buffered Fourier domain mode locked (FDML) laser operating at a center wavelength of 1315 nm and a sweep rate of 240 kHz. High contrast is observed between phantoms containing nanoshells and phantoms without nanoshells. This technique represents a new method for detecting gold nanoparticle contrast agents with excellent signal-to-noise performance at high speeds using OCT.}, } |
M.
Mueller,
G.
Huettmann,
N.
Koop, and
P.
Steven,
Minimal-Invasive Imaging of Ocular Surface Pathologies - Confocal vs. Two-Photon Microscopy, Investigative Ophthalmology & Visual Science , vol. 49, no. 13, pp. 2258-2258, 2008.
Minimal-Invasive Imaging of Ocular Surface Pathologies - Confocal vs. Two-Photon Microscopy, Investigative Ophthalmology & Visual Science , vol. 49, no. 13, pp. 2258-2258, 2008.
C
Framme,
J
Roider, and
V.
Gabel,
Grundlagen und klinische Anwendung der Lasertherapie an der Netzhaut, vol. 225, no. 4, pp. 259-268, 2008.
Grundlagen und klinische Anwendung der Lasertherapie an der Netzhaut, vol. 225, no. 4, pp. 259-268, 2008.
C.
Framme,
A.
Walter, and
P.
Prahs,
Comparison of threshold irradiances and online dosimetry for selective retina treatment (SRT) in patients treated with 200 nanoseconds and 1.7 microseconds laser pulses, Lasers Surg Med , vol. 40, no. 9, pp. 616-24, 2008.
Comparison of threshold irradiances and online dosimetry for selective retina treatment (SRT) in patients treated with 200 nanoseconds and 1.7 microseconds laser pulses, Lasers Surg Med , vol. 40, no. 9, pp. 616-24, 2008.
C.
Framme,
J.
Roider,
V.
Gabel, and
R.
Birngruber,
Basic principles and clinical application of retinal laser therapy, Klinische Monatsblatter Fur Augenheilkunde , vol. 225, no. 4, pp. 259-268, 2008.
Basic principles and clinical application of retinal laser therapy, Klinische Monatsblatter Fur Augenheilkunde , vol. 225, no. 4, pp. 259-268, 2008.
DOI: | DOI 10.1055/s-2008-1027202 |
File: | WOS:000255870100001 |
Bibtex: | @article{Framme2008, author = {Framme, C. and Roider, J. and Brinkmann, R. and Birngruber, R. and Gabel, V. P.}, title = {Basic principles and clinical application of retinal laser therapy}, journal = {Klinische Monatsblatter Fur Augenheilkunde}, volume = {225}, number = {4}, pages = {259-268}, note = {301AZ Times Cited:3 Cited References Count:39}, abstract = {The scientific background of laser photocoagulation of the ocular fundus was studied extensively by several investigators in the 1970 s and 1980 s. The basic principles were succesfully resolved during that time and clinical consequences for proper application of the laser photocoagulation for various diseases were deduced. The present paper gives an overview about the physical basics of laser-tissue interactions during and after retinal laser treatment and the particular laser strategies in the treatment of different retinal diseases. Thus, it addresses the issue of the impact on tissue of laser parameters as wavelength, spot size, pulse duration and laser power. Additionally, the different biological tissue reactions after laser treatment are presented, such as, e.g., for retinopexia or macular treatments as well as for diabetic retinopathies. Specific laser strategies such as the selective laser treatment of the RPE (SRT) or the transpupillary thermotherapy (TTT) are presented and discussed.}, keywords = {retina anatomy vitreous subfoveal choroidal neovascularization central vein occlusion transpupillary thermotherapy macular degeneration pigment epithelium photocoagulation argon trial rpe diseases}, ISSN = {0023-2165}, DOI = {DOI 10.1055/s-2008-1027202}, url = {<Go to ISI>://WOS:000255870100001}, year = {2008}, type = {Journal Article} } |
J.
Sandeau,
G.
Caillibotte,
J.
Kandulla,
H.
Elsner, and
G.
Apiou-Sbirlea,
Numerical Modelling of Conductive and Convective Heat Transfers in Retinal Laser Applications, vol. 1, no. 1, pp. 43-52, 2008.
Numerical Modelling of Conductive and Convective Heat Transfers in Retinal Laser Applications, vol. 1, no. 1, pp. 43-52, 2008.
F
Garwe,
U
Bauerschäfer,
A
Csaki,
A
Steinbrück,
K
Ritter,
A
Bochmann,
J
Bergmann,
A
Weise,
D
Akimov,
G
Maubach,
K
König,
W
Paa,
J.
Popp, and
W
Fritzsche,
Optically controlled thermal management on the nanometer length scale, Nanotechnology , vol. 19, no. 5, pp. 055207, 2008.
Optically controlled thermal management on the nanometer length scale, Nanotechnology , vol. 19, no. 5, pp. 055207, 2008.
S
Koinzer,
H
Elsner,
C
Klatt, and
J
Roider,
Selective Retina Therapy (SRT) of chronic subfoveal fluid after surgery of rhegmatogenous retinal detachment: three case reports, vol. 246, no. 10, pp. 1373-8, 2008.
Selective Retina Therapy (SRT) of chronic subfoveal fluid after surgery of rhegmatogenous retinal detachment: three case reports, vol. 246, no. 10, pp. 1373-8, 2008.
J Neumann,
Self-limited growth of laser-induced vapor bubbles around single micro-absorbers, Appl Phys Lett , vol. 93, pp. 033901, 2008.
Self-limited growth of laser-induced vapor bubbles around single micro-absorbers, Appl Phys Lett , vol. 93, pp. 033901, 2008.
L.
Ramrath,
G.
Moreno,
H.
Mueller,
T.
Bonin,
G.
Huettmann, and
A.
Schweikard,
Towards multi-directional OCT for speckle noise reduction, Med Image Comput Comput Assist Interv , vol. 11, no. Pt 1, pp. 815-23, 2008.
Towards multi-directional OCT for speckle noise reduction, Med Image Comput Comput Assist Interv , vol. 11, no. Pt 1, pp. 815-23, 2008.
T.
Just,
E.
Lankenau,
G.
Huettmann, and
H.
Pau,
Optical coherence tomography as a guide for cochlear implant surgery, in Progress in Biomedical Optics and Imaging , Nikiforos, K. and Bernard, C. and Haishan, Z., Eds. SPIE 6842, 2008. pp. F1-F6.
Optical coherence tomography as a guide for cochlear implant surgery, in Progress in Biomedical Optics and Imaging , Nikiforos, K. and Bernard, C. and Haishan, Z., Eds. SPIE 6842, 2008. pp. F1-F6.
File: | 12.771446 |
Bibtex: | @inproceedings{Just-2008, author = {Just, T. and Lankenau, E. and Huettmann, G. and Pau, H.W.}, title = {Optical coherence tomography as a guide for cochlear implant surgery}, booktitle = {Progress in Biomedical Optics and Imaging}, editor = {Nikiforos, K. and Bernard, C. and Haishan, Z.}, publisher = {SPIE 6842}, pages = {F1-F6}, url = { https://doi.org/10.1117/12.771446}, year = { 2008} } |
J Kandulla,
Non invasive real-time temperature determination during laser treatments at the retina, Photonik international , vol. 2008/1, pp. 42-45, 2008.
Non invasive real-time temperature determination during laser treatments at the retina, Photonik international , vol. 2008/1, pp. 42-45, 2008.
P.
Steven,
J.
Rupp,
N.
Koop,
C.
Lensing,
H.
Laqua, and
A.
Gebert,
Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue, Invest Ophthalmol Vis Sci , vol. 49, no. 4, pp. 1512-7, 2008.
Experimental induction and three-dimensional two-photon imaging of conjunctiva-associated lymphoid tissue, Invest Ophthalmol Vis Sci , vol. 49, no. 4, pp. 1512-7, 2008.
P.
Steven, and
N.
Koop,
Confocal microscopy versus two-photon microscopy: imaging of ocular surface pathologies, Ammasi, Periasamy and Peter, T. C. So, Eds. SPIE, 2008. pp. 686023.
Confocal microscopy versus two-photon microscopy: imaging of ocular surface pathologies, Ammasi, Periasamy and Peter, T. C. So, Eds. SPIE, 2008. pp. 686023.
J.
Phillips,
E.
Fischer,
M.
Baron,
N.
Dries,
F.
Facchinelli,
M.
Kutzer,
R.
Rahmanzadeh,
D.
Remus, and
D.
Bartels,
Lindernia brevidens: a novel desiccation-tolerant vascular plant, endemic to ancient tropical rainforests, in Plant J , 2008, pp. 938-48.
Lindernia brevidens: a novel desiccation-tolerant vascular plant, endemic to ancient tropical rainforests, in Plant J , 2008, pp. 938-48.
DOI: | 10.1111/j.1365-313X.2008.03478.x |
Bibtex: | @incollection{Phillips, author = {Phillips, J. R. and Fischer, E. and Baron, M. and van den Dries, N. and Facchinelli, F. and Kutzer, M. and Rahmanzadeh, R. and Remus, D. and Bartels, D.}, title = {Lindernia brevidens: a novel desiccation-tolerant vascular plant, endemic to ancient tropical rainforests}, booktitle = {Plant J}, volume = {54}, edition = {2008/03/19}, pages = {938-48}, note = {Phillips, Jonathan R Fischer, Eberhard Baron, Miriam van den Dries, Niels Facchinelli, Fabio Kutzer, Michael Rahmanzadeh, Ramtin Remus, Daniela Bartels, Dorothea England Plant J. 2008 Jun;54(5):938-48. Epub 2008 Mar 13.}, abstract = {A particular adaptation to survival under limited water availability has been realized in the desiccation-tolerant resurrection plants, which tend to grow in a habitat with seasonal rainfall and long dry periods. One of the best-studied examples is Craterostigma plantagineum. Here we report an unexpected finding: Lindernia brevidens, a close relative of C. plantagineum, exhibits desiccation tolerance, even though it is endemic to the montane rainforests of Tanzania and Kenya, where it never experiences seasonal dry periods. L. brevidens has been found exclusively in two fragments of the ancient Eastern Arc Mountains, which were protected from the devastating Pleistocene droughts by the stable Indian Ocean temperature. Analysis of the microhabitat reveals that L. brevidens is found in the same habitat as hygrophilous plant species, which further indicates that the plant never dries out completely. The objective of this investigation was to address whether C. plantagineum and L. brevidens have desiccation-related pathways in common, or whether L. brevidens has acquired novel pathways. A third, closely related, desiccation-sensitive species, Lindernia subracemosa, has been included for comparison. Mechanisms that confer cellular protection during extreme water loss are well conserved between C. plantagineum and L. brevidens, including the interconversion of 2-octulose to sucrose within the two desiccation-tolerant species. Furthermore, transcriptional control regions of desiccation-related genes belonging to the late embryogenesis abundant (LEA) protein family are also highly conserved. We propose that L. brevidens is a neoendemic species that has retained desiccation tolerance through genome stability, despite tolerance being superfluous to environmental conditions.}, keywords = {Adaptation, Physiological Gene Expression Profiling Genome, Plant Lamiaceae/genetics/metabolism/ physiology Sucrose/metabolism Tropical Climate Water}, year = {2008} } |
C.
Yao,
Z.
Zhang,
R.
Rahmanzadeh, and
G.
Hüttmann,
Laser-based gene transfection and gene therapy, IEEE Trans Nanobioscience , vol. 7, no. 2, pp. 111-9, 2008.
Laser-based gene transfection and gene therapy, IEEE Trans Nanobioscience , vol. 7, no. 2, pp. 111-9, 2008.
DOI: | 10.1109/TNB.2008.2000742 |
Bibtex: | @article{Yao, author = {Yao, C. P. and Zhang, Z. X. and Rahmanzadeh, R. and Huettmann, G.}, title = {Laser-based gene transfection and gene therapy}, journal = {IEEE Trans Nanobioscience}, volume = {7}, number = {2}, pages = {111-9}, note = {Yao, C P Zhang, Z X Rahmanzadeh, R Huettmann, G Research Support, Non-U.S. Gov't Review United States IEEE Trans Nanobioscience. 2008 Jun;7(2):111-9.}, abstract = {The plasma membrane of mammalian cells can be transiently permeablized by optical means and exogenous materials or genes can be introduced into the cytoplasm of living cells. Until now, few mechanisms were exploited for the manipulation: laser is directly and tightly focused on the cells for optoinjection, laser-induced stress waves, photochemical internalization, and irradiation of selective cell targeting with light-absorbing particles. During the past few years, extensive progress and numerous breakthroughs have been made in this area of research. This review covers four different laser-assisted transfection techniques and their advantages and disadvantages. Universality towards various cell lines is possibly the main advantage of laser-assisted optoporation in comparison with presently existing methods of cell transfection.}, keywords = {Cell Membrane/ radiation effects DNA/ administration & dosage/ pharmacokinetics Gene Therapy/ methods Lasers Transfection/ methods}, year = {2008} } |
C
Framme,
G
Schüle,
K
Kobuch, and
B
Flucke,
Investigation of Selective Retina Treatment (SRT) by Means of 8 ns Laser Pulses in a Rabbit Model, vol. 40, pp. 20-27, 2008.
Investigation of Selective Retina Treatment (SRT) by Means of 8 ns Laser Pulses in a Rabbit Model, vol. 40, pp. 20-27, 2008.
Y.
Chen,
J.
Schmitt,
J.
Connolly, and
J.
Fujimoto,
In vivo endomicroscopy using three-dimensional optical coherence tomography and {Fourier} domain mode locked lasers, in Biomedical Optics (BiOS) 2008 , Izatt, Joseph A. and Fujimoto, James G. and Tuchin, Valery V., Eds. International Society for Optics and Photonics, 2008. pp. 684708--684708--7.
In vivo endomicroscopy using three-dimensional optical coherence tomography and {Fourier} domain mode locked lasers, in Biomedical Optics (BiOS) 2008 , Izatt, Joseph A. and Fujimoto, James G. and Tuchin, Valery V., Eds. International Society for Optics and Photonics, 2008. pp. 684708--684708--7.
DOI: | 10.1117/12.761850 |
File: | proceeding.aspx |
Bibtex: | @InProceedings{HU_2008_Adlera, Title = {{In vivo endomicroscopy using three-dimensional optical coherence tomography and {Fourier} domain mode locked lasers}}, Author = {Adler, Desmond C. and Chen, Yu and Huber, Robert and Schmitt, Joseph and Connolly, James and Fujimoto, James G.}, Booktitle = {Biomedical Optics (BiOS) 2008}, Year = {2008}, Editor = {Izatt, Joseph A. and Fujimoto, James G. and Tuchin, Valery V.}, Month = feb, Pages = {684708--684708--7}, Publisher = {International Society for Optics and Photonics}, Doi = {10.1117/12.761850}, Url = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1326810\&resultClick=1} } |
X.
Qu,
J.
Wang,
Z.
Zhang,
N.
Koop,
R.
Rahmanzadeh, and
G.
Hüttmann,
Imaging of cancer cells by multiphoton microscopy using gold nanoparticles and fluorescent dyes, vol. 13, no. 3, pp. 031217, 2008.
Imaging of cancer cells by multiphoton microscopy using gold nanoparticles and fluorescent dyes, vol. 13, no. 3, pp. 031217, 2008.
DOI: | 10.1117/1.2942373 |
ISBN: | 1083-3668 (Print) 1083-3668 (Linking) |
Bibtex: | @misc{Qu, author = {Qu, X. and Wang, J. and Zhang, Z. and Koop, N. and Rahmanzadeh, R. and Huttmann, G.}, title = {Imaging of cancer cells by multiphoton microscopy using gold nanoparticles and fluorescent dyes}, volume = {13}, number = {3}, pages = {031217}, note = {Using Smart Source Parsing May-Jun}, abstract = {Due to their unique optical properties, optical probes, including metal nanoparticles (NPs) and fluorescent dyes, are increasingly used as labeling tools in biological imaging. Using multiphoton microscopy and fluorescence lifetime imaging (FLIM) at 750-nm excitation, we recorded intensity and FLIM images from gold NPs (30 nm) and the fluorescent dye Alexa 488 (A488) conjugated with monoclonal ACT-1 antibodies as well as Hoechst 33258 (H258) after incubation with the lymphoma cell line (Karpas-299). From the FLIM images, we can easily discriminate the imaging difference between cells and optical probes according to their distinct fluorescence lifetimes (cellular autofluorescence: 1 to 2 ns; gold NPs: <0.02 ns; A488: 3.5 ns; H258: 2.5 ns). The NP-ACT-1 and A488-ACT-1 conjugates were bound homogeneously on the surface of cells, whereas H258 stained the cell nucleus. We demonstrate that the emission intensity of gold NPs is about ten times stronger than that of the autofluorescence of Karpas-299 cells at the same excitation power. Compared with fluorescent dyes, stronger emission is also observed from gold NPs. Together with their high photostability, these observations suggest that gold NPs are a viable alternative to fluorescent dyes for cellular imaging and cancer diagnosis.}, ISBN = {1083-3668 (Print) 1083-3668 (Linking)}, year = {2008} } |
S.
Kantelhardt,
H.
Diddens,
J.
Leppert,
V.
Rohde, and
A.
Giese,
Multiphoton excited fluorescence microscopy of 5-ALA induced fluorescence in exprimental, Laser Surg Med , vol. 40 , no. 4, pp. 273-81, 2008.
Multiphoton excited fluorescence microscopy of 5-ALA induced fluorescence in exprimental, Laser Surg Med , vol. 40 , no. 4, pp. 273-81, 2008.
A.
Vogel,
N.
Linz,
S.
Freidank, and
G.
Paltauf,
Femtosecond-laser-induced nanocavitation in water: implications for optical breakdown threshold and cell surgery, vol. 100, no. 3, pp. 23, 2008.
Femtosecond-laser-induced nanocavitation in water: implications for optical breakdown threshold and cell surgery, vol. 100, no. 3, pp. 23, 2008.
C.
Framme,
H.
Sachs,
K.
Kobuch, and
B.
Flucke,
Clinical evaluation of experimentally induced choroidal neovascularizations in Pigmented rabbits by subretinal injection of lipid hydroperoxide and consecutive preliminary photodynamic treatment with tookad, Ophthalmologica , vol. 222, no. 4, pp. 254-264, 2008.
Clinical evaluation of experimentally induced choroidal neovascularizations in Pigmented rabbits by subretinal injection of lipid hydroperoxide and consecutive preliminary photodynamic treatment with tookad, Ophthalmologica , vol. 222, no. 4, pp. 254-264, 2008.
DOI: | Doi 10.1159/000136903 |
File: | WOS:000258536200008 |
Bibtex: | @article{Framme2008, author = {Framme, C. and Sachs, H. G. and Kobuch, K. and Flucke, B. and Birngruber, R.}, title = {Clinical evaluation of experimentally induced choroidal neovascularizations in Pigmented rabbits by subretinal injection of lipid hydroperoxide and consecutive preliminary photodynamic treatment with tookad}, journal = {Ophthalmologica}, volume = {222}, number = {4}, pages = {254-264}, note = {338UZ Times Cited:3 Cited References Count:27}, abstract = {Purpose: Up to date several approaches have been undertaken to achieve an 'easy-to-handle' animal model of choroidal neovascularizations (CNVs) in rabbits; however, so far in none of the studies could healthy retinal tissue be maintained, which is mandatory to further investigate the effects of photodynamic therapy (PDT) or anti-vascular-endothelial-growth-factor treatments. It was our aim to reevaluate and verify the method of inducing experimental CNVs in rabbits using subretinally injected linoleic acid hydroperoxicle (LHP) as proposed by Tamai et al. and to use it for experimental PDT. Material and Methods: In 33 eyes of Chinchilla breed rabbits LHP of two different concentrations (25 and 100 mu g/50 mu l) was injected into the subretinal space via a transvitreal approach under guidance of an operation microscope. Ophthalmoscopic and angiographic examinations were performed on days 3, 7, 14 and 28 after surgery. Preliminary PDT with different experimental parameter sets was performed in 3 eyes using the new photosensitizer Tookad. Results: Using LHP in the higher concentration, an angiographically determined CNV induction was observed in 27% of all injection sites (n = 34) on days 14 and 28 revealing early well-demarcated and progressive leakage. No CNV was detected at the lower LHP concentration (60 injection sites). Subretinal CNV was verified histologically revealing vessel formation above the retinal pigment epithelium level. Herein, a significant damage to the outer retinal layers was always observed; however, the general structure of the choriocapillary layer was maintained. Tookad PDT was clinically able to completely stop leakage in I case and reduce leakage in 2 cases. Histologically the choriocapillary layer was occluded. Conclusion: Subretinal injection of LHP induces angiographically well-demarcated classic CNVs in rabbits; however, the CNV rate was low, and histology revealed severe damage of the outer retinal layers but not of the choriocapillary layer, which is important for studying PDT interactions. Preliminary experimental PDT could clinically stop or reduce leakage from angiographic CNV. Due to the small CNV rate and the significant collateral retinal tissue damage, this model seems to be only of partial suitability for investigating new treatment modalities in CNV. Copyright (c) 2008 S. Karger AG, Basel.}, keywords = {age-related macular degeneration animal model choroidal neovascularization retinal pigment epithelium linoleic acid hydroperoxide senile macular degeneration bruchs membrane ranibizumab verteporfin therapy growth model}, ISSN = {0030-3755}, DOI = {Doi 10.1159/000136903}, url = {<Go to ISI>://WOS:000258536200008}, year = {2008}, type = {Journal Article} } |
2007
D.
Adler,
Y.
Chen,
R.
Huber,
J.
Schmitt,
J.
Connolly, and
J.
Fujimoto,
Three-dimensional endomicroscopy using optical coherence tomography, Nature Photonics , vol. 1, no. 12, pp. 709-716, Nov. 2007.
Three-dimensional endomicroscopy using optical coherence tomography, Nature Photonics , vol. 1, no. 12, pp. 709-716, Nov. 2007.
DOI: | 10.1038/nphoton.2007.228 |
Bibtex: | @article{HU_2007_Adlera, Title = {Three-dimensional endomicroscopy using optical coherence tomography}, Author = {Adler, Desmond C. and Chen, Yu and Huber, Robert and Schmitt, Joseph and Connolly, James and Fujimoto, James G.}, Journal = {Nature Photonics}, Year = {2007}, Month = nov, Number = {12}, Pages = {709--716}, Volume = {1}, Doi = {10.1038/nphoton.2007.228}, Timestamp = {2014.11.20}, ISSN = {1749-4885} } |
L.
Kranendonk,
X.
An,
A.
Caswell,
R.
Herold,
S.
Sanders,
R.
Huber,
J.
Fujimoto,
Y.
Okura, and
Y.
Urata,
High speed engine gas thermometry by Fourier-domain mode-locked laser absorption spectroscopy, Opt. Express , vol. 15, no. 23, pp. 15115-15128, Nov. 2007. Optica Publishing Group.
High speed engine gas thermometry by Fourier-domain mode-locked laser absorption spectroscopy, Opt. Express , vol. 15, no. 23, pp. 15115-15128, Nov. 2007. Optica Publishing Group.
DOI: | 10.1364/OE.15.015115 |
Bibtex: | @article{Kranendonk:07, author = {Laura A. Kranendonk and Xinliang An and Andrew W. Caswell and Randy E. Herold and Scott T. Sanders and Robert Huber and James G. Fujimoto and Yasuhiro Okura and Yasuhiro Urata}, journal = {Opt. Express}, keywords = {Spectrometers and spectroscopic instrumentation; Lasers, tunable; Spectroscopy, fluorescence and luminescence; Absorption; Spectroscopy, diode lasers; Spectroscopy, infrared; Fourier transform spectroscopy; Laser modes; Laser sources; Laser spectroscopy; Molecular spectra; Optical coherence tomography}, number = {23}, pages = {15115--15128}, publisher = {Optica Publishing Group}, title = {High speed engine gas thermometry by Fourier-domain mode-locked laser absorption spectroscopy}, volume = {15}, month = {Nov}, year = {2007}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-15-23-15115}, doi = {10.1364/OE.15.015115}, abstract = {We present a novel method for low noise, high-speed, real-time spectroscopy to monitor molecular absorption spectra. The system is based on a rapidly swept, narrowband CW Fourier-domain mode-locked (FDML) laser source for spectral encoding in time and an optically time-multiplexed split-pulse data acquisition system for improved noise performance and sensitivity. An acquisition speed of $\sim$100 kHz, a spectral resolution better than 0.1 nm over a wavelength range of $\sim$1335--1373 nm and a relative noise level of $\sim$5 mOD ($\sim$1\% minimum detectable base-e absorbance) are achieved. The system is applied for crank-angle-resolved gas thermometry by H2O absorption spectroscopy in an engine motoring at 600 and 900 rpm with a precision of $\sim$1\%. Influences of various noise sources such as laser phase and intensity noise, trigger and synchronization jitter in the electronic detection system, and the accuracy of available H2O absorption databases are discussed.}, } |
D.
Adler,
J.
Stenger,
I.
Gorczynska,
H.
Lie,
T.
Hensick,
R.
Spronk,
S.
Wolohojian,
N.
Khandekar,
J.
Jiang,
S.
Barry,
A.
Cable,
R.
Huber, and
J.
Fujimoto,
Comparison of three-dimensional optical coherence tomography and high resolution photography for art conservation studies, Opt. Express , vol. 15, no. 24, pp. 15972-15986, Nov. 2007. Optica Publishing Group.
Comparison of three-dimensional optical coherence tomography and high resolution photography for art conservation studies, Opt. Express , vol. 15, no. 24, pp. 15972-15986, Nov. 2007. Optica Publishing Group.
DOI: | 10.1364/OE.15.015972 |
Bibtex: | @article{Adler:07, author = {Desmond C. Adler and Jens Stenger and Iwona Gorczynska and Henry Lie and Teri Hensick and Ron Spronk and Stephan Wolohojian and Narayan Khandekar and James Y. Jiang and Scott Barry and Alex E. Cable and Robert Huber and James G. Fujimoto}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Photography; Three-dimensional image acquisition; Optical inspection; Lasers, tunable; Three-dimensional microscopy; Digital photography; Fourier domain mode locking; Image processing; Speckle interferometry; Three dimensional imaging; Three dimensional measurement}, number = {24}, pages = {15972--15986}, publisher = {Optica Publishing Group}, title = {Comparison of three-dimensional optical coherence tomography and high resolution photography for art conservation studies}, volume = {15}, month = {Nov}, year = {2007}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-15-24-15972}, doi = {10.1364/OE.15.015972}, abstract = {Gold punchwork and underdrawing in Renaissance panel paintings are analyzed using both three-dimensional swept source/Fourier domain optical coherence tomography (3D-OCT) and high resolution digital photography. 3D-OCT can generate en face images with micrometer-scale resolutions at arbitrary sectioning depths, rejecting out-of-plane light by coherence gating. Therefore 3D-OCT is well suited for analyzing artwork where a surface layer obscures details of interest. 3D-OCT also enables cross-sectional imaging and quantitative measurement of 3D features such as punch depth, which is beneficial for analyzing the tools and techniques used to create works of art. High volumetric imaging speeds are enabled by the use of a Fourier domain mode locked (FDML) laser as the 3D-OCT light source. High resolution infrared (IR) digital photography is shown to be particularly useful for the analysis of underdrawing, where the materials used for the underdrawing and paint layers have significantly different IR absorption properties. In general, 3D-OCT provides a more flexible and comprehensive analysis of artwork than high resolution photography, but also requires more complex instrumentation and data analysis.}, } |
R.
Huber,
D.
Adler,
V.
Srinivasan, and
J.
Fujimoto,
Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second, Opt. Lett. , vol. 32, no. 14, pp. 2049-2051, 07 2007. Optica Publishing Group.
Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second, Opt. Lett. , vol. 32, no. 14, pp. 2049-2051, 07 2007. Optica Publishing Group.
DOI: | 10.1364/OL.32.002049 |
Bibtex: | @article{Huber:07, author = {R. Huber and D. C. Adler and V. J. Srinivasan and J. G. Fujimoto}, journal = {Opt. Lett.}, keywords = {Optical coherence tomography; Lasers, tunable; Medical and biological imaging; Amplified spontaneous emission; Fourier domain mode locking; Image quality; Optical coherence tomography; Retina; Retina scanning}, number = {14}, pages = {2049--2051}, publisher = {Optica Publishing Group}, title = {Fourier domain mode locking at 1050 nm for ultra-high-speed optical coherence tomography of the human retina at 236,000 axial scans per second}, volume = {32}, month = {Jul}, year = {2007}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-32-14-2049}, doi = {10.1364/OL.32.002049}, abstract = {A Fourier domain mode-locked (FDML) laser at 1050 nm for ultra-high-speed optical coherence tomography (OCT) imaging of the human retina is demonstrated. Achievable performance, physical limitations, design rules, and scaling principles for FDML operation and component choice in this wavelength range are discussed. The fiber-based FDML laser operates at a sweep rate of 236 kHz over a 63 nm tuning range, with 7 mW average output power. Ultra-high-speed retinal imaging is demonstrated at 236,000 axial scans per second. This represents a speed improvement of ~10{\texttimes} over typical high-speed OCT systems, paving the way for densely sampled volumetric data sets and new imaging protocols.}, } |
R.
Huber,
V.
Srinivasan,
D.
Adler,
I.
Gorczynska, and
J.
Fujimoto,
Fourier Domain Mode Locking (FDML) in the non-zero dispersion regime: A laser for ultrahigh-speed retinal OCT imaging at 236kHz line rate, in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies , Optica Publishing Group, 052007. pp. CThAA5.
Fourier Domain Mode Locking (FDML) in the non-zero dispersion regime: A laser for ultrahigh-speed retinal OCT imaging at 236kHz line rate, in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies , Optica Publishing Group, 052007. pp. CThAA5.
DOI: | 10.1109/CLEO.2007.4452681} |
Bibtex: | @inproceedings{Huber:07, author = {Robert Huber and Vivek J. Srinivasan and Desmond C. Adler and I. Gorczynska and James G. Fujimoto}, booktitle = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies}, journal = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference and Photonic Applications Systems Technologies}, keywords = {General physics; General science; Fourier domain mode locking; Image quality; In vivo imaging; Laser sources; Ophthalmic imaging; Optical coherence tomography}, pages = {CThAA5}, publisher = {Optica Publishing Group}, title = {Fourier Domain Mode Locking (FDML) in the non-zero dispersion regime: A laser for ultrahigh-speed retinal OCT imaging at 236kHz line rate}, year = {2007}, url = {https://opg.optica.org/abstract.cfm?URI=CLEO-2007-CThAA5}, abstract = {Fourier Domain Mode Locking (FDML) in the 1070nm wavelength range is investigated. Problems, design rules and the performance of an FDML laser with a dispersive cavity are discussed. Retinal OCT imaging at 236kHz is demonstrated.}, } |
D.
Adler,
R.
Huber, and
J.
Fujimoto,
Optical coherence tomography phase microscopy using buffered fourier domain mode locked (FDML) lasers at up to 370,000 lines per second, in 2007 Conference on Lasers and Electro-Optics (CLEO) , IEEE, 052007. pp. 1-2.
Optical coherence tomography phase microscopy using buffered fourier domain mode locked (FDML) lasers at up to 370,000 lines per second, in 2007 Conference on Lasers and Electro-Optics (CLEO) , IEEE, 052007. pp. 1-2.
DOI: | 10.1109/CLEO.2007.4452406 |
Bibtex: | @INPROCEEDINGS{4452406, author={Adler, Desmond C. and Huber, Robert and Fujimoto, James G.}, booktitle={2007 Conference on Lasers and Electro-Optics (CLEO)}, title={Optical Coherence Tomography Phase Microscopy Using Buffered Fourier Domain Mode Locked (FDML) Lasers at up to 370,000 Lines per Second}, year={2007}, volume={}, number={}, pages={1-2}, abstract={Buffered FDML lasers are applied for phase-sensitive sub-nanometer OCT phase microscopy and dynamic surface displacement measurements at speeds up to 370,000 axial lines per second. Excellent phase stability is demonstrated at high speeds.}, keywords={}, doi={10.1109/CLEO.2007.4452406}, ISSN={2160-9004}, month={May},} |
S.
Huang,
A.
Aguirre,
R.
Huber,
D.
Adler, and
J.
Fujimoto,
Swept source optical coherence microscopy using a Fourier domain mode-locked laser, Opt. Express , vol. 15, no. 10, pp. 6210-6217, 05 2007. Optica Publishing Group.
Swept source optical coherence microscopy using a Fourier domain mode-locked laser, Opt. Express , vol. 15, no. 10, pp. 6210-6217, 05 2007. Optica Publishing Group.
DOI: | 10.1364/OE.15.006210 |
Bibtex: | @article{Huang:07, author = {Shu-Wei Huang and Aaron D. Aguirre and Robert A. Huber and Desmond C. Adler and James G. Fujimoto}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Medical and biological imaging; Confocal microscopy; Three-dimensional microscopy; Image quality; Laser sources; Mode locking; Optical delay lines; Swept sources; Three dimensional imaging}, number = {10}, pages = {6210--6217}, publisher = {Optica Publishing Group}, title = {Swept source optical coherence microscopy using a Fourier domain mode-locked laser}, volume = {15}, month = {May}, year = {2007}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-15-10-6210}, doi = {10.1364/OE.15.006210}, abstract = {Swept source optical coherence microscopy (OCM) enables cellular resolution en face imaging as well as integration with optical coherence tomography (OCT) cross sectional imaging. A buffered Fourier domain mode-locked (FDML) laser light source provides high speed, three dimensional imaging. Image resolutions of 1.6 $\mu$m {\texttimes} 8 $\mu$m (transverse {\texttimes} axial) with a 220 $\mu$m {\texttimes} 220 $\mu$m field of view and sensitivity higher than 98 dB are achieved. Three dimensional cellular imaging is demonstrated in vivo in the Xenopus laevis tadpole and ex vivo in the rat kidney and human colon.}, } |
M.
Jenkins,
D.
Adler,
M.
Gargesha,
R.
Huber,
F.
Rothenberg,
J.
Belding,
M.
Watanabe,
D.
Wilson,
J.
Fujimoto, and
A.
Rollins,
Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser, Opt. Express , vol. 15, no. 10, pp. 6251-6267, 05 2007. Optica Publishing Group.
Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser, Opt. Express , vol. 15, no. 10, pp. 6251-6267, 05 2007. Optica Publishing Group.
DOI: | 10.1364/OE.15.006251 |
Bibtex: | @article{Jenkins:07, author = {M. W. Jenkins and D. C. Adler and M. Gargesha and R. Huber and F. Rothenberg and J. Belding and M. Watanabe and D. L. Wilson and J. G. Fujimoto and A. M. Rollins}, journal = {Opt. Express}, keywords = {Three-dimensional image processing; Lasers; Medical and biological imaging; Optical coherence tomography; Developmental biology; Gated imaging; Imaging systems; Laser Doppler velocimetry; Laser modes; Mode locking}, number = {10}, pages = {6251--6267}, publisher = {Optica Publishing Group}, title = {Ultrahigh-speed optical coherence tomography imaging and visualization of the embryonic avian heart using a buffered Fourier Domain Mode Locked laser}, volume = {15}, month = {May}, year = {2007}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-15-10-6251}, doi = {10.1364/OE.15.006251}, abstract = {The embryonic avian heart is an important model for studying cardiac developmental biology. The mechanisms that govern the development of a four-chambered heart from a peristaltic heart tube are largely unknown due in part to a lack of adequate imaging technology. Due to the small size and rapid motion of the living embryonic avian heart, an imaging system with high spatial and temporal resolution is required to study these models. Here, an optical coherence tomography (OCT) system using a buffered Fourier Domain Mode Locked (FDML) laser is applied for ultrahigh-speed non-invasive imaging of embryonic quail hearts at 100,000 axial scans per second. The high scan rate enables the acquisition of high temporal resolution 2D datasets (195 frames per second or 5.12 ms between frames) and 3D datasets (10 volumes per second). Spatio-temporal details of cardiac motion not resolvable using previous OCT technology are analyzed. Visualization and measurement techniques are developed to non-invasively observe and quantify cardiac motion throughout the brief period of systole (less than 50 msec) and diastole. This marks the first time that the preseptated embryonic avian heart has been imaged in 4D without the aid of gating and the first time it has been viewed in cross section during looping with extremely high temporal resolution, enabling the observation of morphological dynamics of the beating heart during systole.}, } |
D.
Adler,
R.
Huber, and
J.
Fujimoto,
Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers, Opt. Lett. , vol. 32, no. 6, pp. 626-628, 03 2007. Optica Publishing Group.
Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers, Opt. Lett. , vol. 32, no. 6, pp. 626-628, 03 2007. Optica Publishing Group.
DOI: | 10.1364/OL.32.000626 |
Bibtex: | @article{Adler:07, author = {Desmond C. Adler and Robert Huber and James G. Fujimoto}, journal = {Opt. Lett.}, keywords = {Optical coherence tomography; Phase measurement; Lasers, tunable; Amplified spontaneous emission; Laser sources; Mode locking; Optical coherence tomography; Phase measurement; Swept lasers}, number = {6}, pages = {626--628}, publisher = {Optica Publishing Group}, title = {Phase-sensitive optical coherence tomography at up to 370,000 lines per second using buffered Fourier domain mode-locked lasers}, volume = {32}, month = {Mar}, year = {2007}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-32-6-626}, doi = {10.1364/OL.32.000626}, abstract = {Buffered Fourier domain mode-locked (FDML) lasers are demonstrated for dynamic phase-sensitive optical coherence tomography (OCT) and 3D OCT phase microscopy. Systems are operated at sweep speeds of 42, 117, and 370 kHz, and displacement sensitivities of 39, 52, and 102 pm are achieved, respectively. Sensitivities are comparable to spectrometer-based OCT phase microscopy systems, but much faster acquisition speeds are possible. An additional factor of sqrt 2 improvement in noise performance is observed for differential phase measurements, which is important for Doppler OCT. Dynamic measurements of piezoelectric transducer motion and static 3D OCT phase microscopy are demonstrated. Buffered FDML lasers provide excellent displacement sensitivities at extremely high sweep speeds.}, } |
R.
Huber,
D.
Adler,
V.
Srinivasan,
I.
Gorczynska, and
J.
Fujimoto,
Fourier domain mode-locked (FDML) lasers at 1050 nm and 202,000 sweeps per second for OCT retinal imaging, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 022007. pp. 642907.
Fourier domain mode-locked (FDML) lasers at 1050 nm and 202,000 sweeps per second for OCT retinal imaging, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 022007. pp. 642907.
DOI: | 10.1117/12.704084 |
Bibtex: | @inproceedings{10.1117/12.704084, author = {Robert A. Huber and Desmond C. Adler and Vivek J. Srinivasan and Iwona M Gorczynska and James G. Fujimoto}, title = {{Fourier domain mode-locked (FDML) lasers at 1050 nm and 202,000 sweeps per second for OCT retinal imaging}}, volume = {6429}, booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI}, editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {642907}, abstract = {Retinal imaging ranks amongst the most important clinical applications for optical coherence tomography (OCT) [1, 2]. The recent demonstration of increased sensitivity [3-6] in Fourier Domain detection [7, 8] has opened the way for dramatically higher imaging speeds, up to axial scan rates of several tens of kilohertz. However, these imaging speeds are still not sufficient for high density 3D datasets and a further increase to several hundreds of kilohertz is necessary. In this paper we demonstrate a swept laser source at 1050 nm with a sweep rate of 202 kHz. The laser source provides ~10 mW average output power, up to 60 nm total sweep range and a sensitivity roll off of less than 10 dB over 4 mm. In vivo 2D and 3D imaging of the human retina at a record axial scan rate of 101 kHz is demonstrated. These results suggest that swept source OCT has the potential to significantly outperform spectral/Fourier domain OCT for ophthalmic imaging applications in the future.}, keywords = {tunable laser, optical coherence tomography, Fourier domain mode locking, swept source, OCT, FDML, retinal imaging, ophthalmic imaging}, year = {2007}, doi = {10.1117/12.704084}, URL = {https://doi.org/10.1117/12.704084} } |
D.
Adler,
R.
Huber, and
J.
Fujimoto,
Phase-sensitive optical coherence tomography using buffered Fourier domain mode-locked lasers at up to 370,000 scans per second, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 022007. pp. 64291L.
Phase-sensitive optical coherence tomography using buffered Fourier domain mode-locked lasers at up to 370,000 scans per second, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI , James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin, Eds. SPIE, 022007. pp. 64291L.
DOI: | 10.1117/12.704128 |
Bibtex: | @inproceedings{10.1117/12.704128, author = {Desmond C. Adler and Robert Huber and James G. Fujimoto}, title = {{Phase-sensitive optical coherence tomography using buffered Fourier domain mode-locked lasers at up to 370,000 scans per second}}, volume = {6429}, booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI}, editor = {James G. Fujimoto and Joseph A. Izatt and Valery V. Tuchin}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {64291L}, abstract = {Phase sensitive optical coherence tomography (OCT) can be used to obtain sub-nanometer displacement measurements of biological and non-biological samples. This technique has many applications, including detection of small amplitude surface motion, and high axial resolution OCT phase microscopy. Doppler OCT is another type of phase sensitive imaging, where differential phase measurements are used to detect fluid flow in biological specimens. For all types of phase sensitive OCT, a light source with low phase noise is required in order to provide good displacement sensitivity. High speed imaging is also necessary in order to minimize motion artifacts and enable the detection of fast transient events. In this manuscript, buffered Fourier Domain Mode Locked (FDML) lasers are demonstrated for ultrahigh-speed phase sensitive OCT detection. The lasers are operated at sweep speeds of 42, 117, and 370 kHz, and displacement sensitivities of 39, 52, and 102 pm are achieved, respectively. These displacement sensitivities are comparable to spectrometer-based phase sensitive OCT systems, but acquisition speeds 1.4 - 13x faster are possible using buffered FDML lasers. An additional factor of √2 improvement in noise performance is observed for differential phase measurements, which has important implications for Doppler OCT. Dynamic measurements of rapid, small-amplitude piezoelectric transducer motion are demonstrated. In general, buffered FDML lasers provide excellent displacement sensitivities at extremely high sweep speeds for phase sensitive OCT measurements.}, keywords = {optical coherence tomography, OCT, optical coherence phase microscopy, swept source phase microscopy, doppler optical coherence tomography, frequency swept lasers, Fourier Domain Mode Locked lasers, FDML}, year = {2007}, doi = {10.1117/12.704128}, URL = {https://doi.org/10.1117/12.704128} } |
V.
Srinivasan,
R.
Huber,
I.
Gorczynska,
J.
Fujimoto,
J.
Jiang,
P.
Reisen, and
A.
Cable,
High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm, Opt. Lett. , vol. 32, no. 4, pp. 361-363, 02 2007. Optica Publishing Group.
High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm, Opt. Lett. , vol. 32, no. 4, pp. 361-363, 02 2007. Optica Publishing Group.
DOI: | 10.1364/OL.32.000361 |
Bibtex: | @article{Srinivasan:07, author = {V. J. Srinivasan and R. Huber and I. Gorczynska and J. G. Fujimoto and J. Y. Jiang and P. Reisen and A. E. Cable}, journal = {Opt. Lett.}, keywords = {Optical coherence tomography; Lasers, tunable; Medical and biological imaging; Optical coherence tomography; Retina scanning; Semiconductor lasers; Semiconductor optical amplifiers; Spontaneous emission; Tunable lasers}, number = {4}, pages = {361--363}, publisher = {Optica Publishing Group}, title = {High-speed, high-resolution optical coherence tomography retinal imaging with a frequency-swept laser at 850 nm}, volume = {32}, month = {Feb}, year = {2007}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-32-4-361}, doi = {10.1364/OL.32.000361}, abstract = {High-speed, high-resolution optical coherence tomography (OCT) imaging of the human retina is demonstrated using a frequency-swept laser at 850 nm. A compact external cavity semiconductor laser design, optimized for swept-source ophthalmic OCT, is described. The laser enables an effective 16 kHz sweep rate with \>10 mm coherence length and a tuning range of $\sim$35 nm full width at half-maximum, yielding an axial resolution of \<7 $\mu$m in tissue.}, } |
R.
Quaden,
G.
Klaws, and
G.
Lutter,
Percutaneous aortic valve replacement: first endovascular resection of human aortic valves in situ, Eur J Cardiothorac Surg , vol. 31, no. 2, pp. 305, 2007.
Percutaneous aortic valve replacement: first endovascular resection of human aortic valves in situ, Eur J Cardiothorac Surg , vol. 31, no. 2, pp. 305, 2007.
M.
Löning,
E.
Lankenau,
H.
Diddens,
M.
Krokowski, and
K.
Diedrich,
Optische Kohärenztomographie in der Gynokologie, Der Gynäkologe , vol. 40, no. 5, 2007.
Optische Kohärenztomographie in der Gynokologie, Der Gynäkologe , vol. 40, no. 5, 2007.
J Neumann,
Nucleation dynamics around single microabsorbers in water heated by nanosecond irradiation, J Appl Phys , vol. 101, no. 114701, 2007.
Nucleation dynamics around single microabsorbers in water heated by nanosecond irradiation, J Appl Phys , vol. 101, no. 114701, 2007.
A.
Vogel,
I.
Apitz, and
V.
Venugopalan,
Phase transitions, material ejection, and plume dynamics in pulsed laser ablation of soft biological tissues, in Oscillations, Waves and Interactions, T. Kurz, U. Parlitz, and U. Kaatze, eds.(Universitätsverlag Göttingen, Göttingen, 2007) , Kurtz, T., Parlitz, U. and Kaatze, U., Eds. Göttingen: Universitätsverlag, 2007, pp. 217-258.
Phase transitions, material ejection, and plume dynamics in pulsed laser ablation of soft biological tissues, in Oscillations, Waves and Interactions, T. Kurz, U. Parlitz, and U. Kaatze, eds.(Universitätsverlag Göttingen, Göttingen, 2007) , Kurtz, T., Parlitz, U. and Kaatze, U., Eds. Göttingen: Universitätsverlag, 2007, pp. 217-258.
D
Vogel, and
A.
Gebert,
Mechanisms of laser-induced dissection and transport of histologic specimens, Biophys J , pp. 4481-4500, 2007.
Mechanisms of laser-induced dissection and transport of histologic specimens, Biophys J , pp. 4481-4500, 2007.
File: | biophysj.106.102277 |
Bibtex: | @article{Vogel2007, author = {Vogel, A; Lorenz, K; Horneffer, V; Hüttmann, G; Von Smolinski, D and Gebert, A}, title = {Mechanisms of laser-induced dissection and transport of histologic specimens}, journal = {Biophys J}, url = {https://doi.org/10.1529/biophysj.106.102277}, pages = {4481-4500}, ISSN = {0006-3495}, year = {2007}, type = {Journal Article} } |
S.
Kantelhardt,
J.
Leppert,
J.
Krajewski,
N.
Petkus,
E.
Reusche,
V.
Tronnier, and
A.
Giese,
Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo, Neuro Oncol , vol. 9, no. 2, pp. 103-12, 2007.
Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo, Neuro Oncol , vol. 9, no. 2, pp. 103-12, 2007.
S.
Kantelhardt,
J.
Leppert,
J.
Krajewski,
N.
Petkus,
E.
Reusche,
V.
Tronnier, and
A.
Giese,
Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo, Neuro Oncol , vol. 9, no. 2, pp. 103--12, 2007.
Imaging of brain and brain tumor specimens by time-resolved multiphoton excitation microscopy ex vivo, Neuro Oncol , vol. 9, no. 2, pp. 103--12, 2007.
V.
Rusanov,
H.
Paulsen,
L.
Böttger,
H.
Winkler,
J.
Wolny,
N.
Koop,
T.
Dorn,
C.
Janiak, and
A.
Trautwein,
Mössbauer, nuclear inelastic scattering and density functional studies on the second metastable state of Na2[Fe(CN)5NO]·2H2O, Hyperfine Interactions , vol. 175, no. 1, pp. 141-150, 2007.
Mössbauer, nuclear inelastic scattering and density functional studies on the second metastable state of Na2[Fe(CN)5NO]·2H2O, Hyperfine Interactions , vol. 175, no. 1, pp. 141-150, 2007.
DOI: | 10.1007/s10751-008-9598-8 |
File: | s10751-008-9598-8 |
Bibtex: | @article{Rusanov2007, author = {Rusanov, V. and Paulsen, H. and Böttger, L. H. and Winkler, H. and Wolny, J. A. and Koop, N. and Dorn, Th. and Janiak, C. and Trautwein, A. X.}, title = {Mössbauer, nuclear inelastic scattering and density functional studies on the second metastable state of Na2[Fe(CN)5NO]·2H2O}, journal = {Hyperfine Interactions}, volume = {175}, number = {1}, pages = {141-150}, abstract = {The structure of the light-induced metastable state SII of Na2[Fe(CN)5NO]·2H2O was investigated by transmission Mössbauer spectroscopy (TMS) in the temperature range between 85 and 135 K, nuclear inelastic scattering (NIS) at 98 K using synchrotron radiation and density functional theory (DFT) calculations. The DFT and TMS results strongly support the view that the NO group in SII takes a side-on molecular orientation and, further, is dynamically displaced from one eclipsed, via a staggered, to a second eclipsed orientation. The population conditions for generating SII are optimal for measurements by TMS, yet they are modest for accumulating NIS spectra. Optimization of population conditions for NIS measurements is discussed and new NIS experiments on SII are proposed.}, ISSN = {1572-9540}, DOI = {10.1007/s10751-008-9598-8}, url = {http://dx.doi.org/10.1007/s10751-008-9598-8}, year = {2007}, type = {Journal Article} } |
A.
Vogel,
J.
Noack, and
G.
Paltauf,
Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues, in Laser Ablation and Its Applications , Phipps, Claude, Eds. Springer US, 2007, pp. 231-280.
Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues, in Laser Ablation and Its Applications , Phipps, Claude, Eds. Springer US, 2007, pp. 231-280.
Der Weg in die Zukunft: In-vivo-Pathologie durch Laserscan-Mikroskopie, Der Gynäkologe , vol. 40, no. 5, pp. 372, 2007.
E.
Lankenau,
D.
Klinger,
A.
Malik,
H.
Müller,
S.
Oelckers,
H.
Pau, and
T.
Just,
Combining Optical Coherence Tomographie (OCT) with an operating microscope, in Medical Engineering , Buzug, T.M. and Holz, D. and Weber, S. and Bongartz, J. and Kohl-Bareise, M. and Hartmann, U., Eds. Springer, Berlin, Heidelberg, New York, 2007, pp. pp 343-348.
Combining Optical Coherence Tomographie (OCT) with an operating microscope, in Medical Engineering , Buzug, T.M. and Holz, D. and Weber, S. and Bongartz, J. and Kohl-Bareise, M. and Hartmann, U., Eds. Springer, Berlin, Heidelberg, New York, 2007, pp. pp 343-348.
R.
Rahmanzadeh,
G.
Hüttmann,
J.
Gerdes, and
T.
Scholzen,
Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis, Cell Prolif , vol. 40, no. 3, pp. 422-30, 2007.
Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis, Cell Prolif , vol. 40, no. 3, pp. 422-30, 2007.
DOI: | 10.1111/j.1365-2184.2007.00433.x |
Bibtex: | @article{Rahmanzadeh, author = {Rahmanzadeh, R. and Huttmann, G. and Gerdes, J. and Scholzen, T.}, title = {Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis}, journal = {Cell Prolif}, volume = {40}, number = {3}, pages = {422-30}, note = {Rahmanzadeh, R Huttmann, G Gerdes, J Scholzen, T England Cell Prolif. 2007 Jun;40(3):422-30.}, abstract = {OBJECTIVES: Expression of the nuclear Ki-67 protein (pKi-67) is strongly associated with cell proliferation. For this reason, antibodies against this protein are widely used as prognostic tools for the assessment of cell proliferation in biopsies from cancer patients. Despite this broad application in histopathology, functional evidence for the physiological role of pKi-67 is still missing. Recently, we proposed a function of pKi-67 in the early steps of ribosomal RNA (rRNA) synthesis. Here, we have examined the involvement of pKi-67 in this process by photochemical inhibition using chromophore-assisted light inactivation (CALI). MATERIALS AND METHODS: Anti-pKi-67 antibodies were labelled with the fluorochrome fluorescein 5(6)-isothiocyanate and were irradiated after binding to their target protein. RESULTS: Performing CALI in vitro on cell lysates led to specific cross-linking of pKi-67. Moreover, the upstream binding factor (UBF) necessary for rRNA transcription was also partly subjected to cross-link formation, indicating a close spatial proximity of UBF and pKi-67. CALI in living cells, using micro-injected antibody, caused a striking relocalization of UBF from foci within the nucleoli to spots located at the nucleolar rim or within the nucleoplasm. pKi-67-CALI resulted in dramatic inhibition of RNA polymerase I-dependent nucleolar rRNA synthesis, whereas RNA polymerase II-dependent nucleoplasmic RNA synthesis remained almost unaltered. CONCLUSIONS: Our data presented here argue for a crucial role of pKi-67 in RNA polymerase I-dependent nucleolar rRNA synthesis.}, keywords = {Antibodies, Antinuclear Antibodies, Monoclonal Cell Division/physiology Cell Nucleolus/physiology Fluorescein-5-isothiocyanate Fluorescent Dyes HeLa Cells Humans Ki-67 Antigen/*genetics/*metabolism Photochemistry RNA Polymerase I/metabolism RNA, Ribosomal/*biosynthesis}, year = {2007} } |
A.
Vogel,
J.
Noack,
N.
Linz,
S.
Freidank, and
G.
Paltauf,
Chapter 18 Femtosecond laser nanosurgery of biological cells and tissues, in Handai Nanophotonics , Hiroshi Masuhara, Satoshi Kawata and Fumio, Tokunaga, Eds. Elsevier, 2007, pp. 273-286.
Chapter 18 Femtosecond laser nanosurgery of biological cells and tissues, in Handai Nanophotonics , Hiroshi Masuhara, Satoshi Kawata and Fumio, Tokunaga, Eds. Elsevier, 2007, pp. 273-286.
A.
Fritz,
L.
Ptaszynski,
H.
Stoehr, and
R.
Brinkmann,
Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE), 2007. pp. 66321C-66321C-11.
Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE), 2007. pp. 66321C-66321C-11.
File: | 12.728344 |
Bibtex: | @inproceedings{Fritz2007, author = {Fritz, Andreas and Ptaszynski, Lars and Stoehr, Hardo and Brinkmann, Ralf}, title = {Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE)}, volume = {6632}, pages = {66321C-66321C-11}, note = {10.1117/12.728344}, abstract = {Selective Retina Treatment (SRT) is a new method to treat eye diseases associated with disorders of the RPE. Selective RPE cell damage is achieved by applying a train of 1.7 μs laser pulses at 527 nm. The treatment of retinal diseases as e.g. diabetic maculopathy (DMP), is currently investigated within clinical studies, however 200 ns pulse durations are under investigation. Transient micro bubbles in the retinal pigment epithelium (RPE) are expected to be the origin of cell damage due to irradiation with laser pulses shorter than 50 μs. The bubbles emerge at the strongly absorbing RPE melanosomes. Cell membrane disruption caused by the transient associated volume increase is expected to be the origin of the angiographically observed RPE leakage. We investigate micro bubble formation and dynamics in porcine RPE using pulse durations of 150 ns. A laser interferometry system at 830 nm with the aim of an online dosimetry control for SRT was developed. Bubble formation was detected interferometrically and by fast flash photography. A correlation to cell damage observed with a vitality stain is found. A bubble detection algorithm is presented.}, url = {http://dx.doi.org/10.1117/12.728344}, type = {Conference Proceedings} } |
A.
Vogel,
J.
Noack, and
G.
Paltauf,
Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues Laser Ablation and its Applications, Phipps, Claude, Eds. Springer Berlin / Heidelberg, 2007, pp. 231-280.
Femtosecond Plasma-Mediated Nanosurgery of Cells and Tissues Laser Ablation and its Applications, Phipps, Claude, Eds. Springer Berlin / Heidelberg, 2007, pp. 231-280.
K.
Herrmann,
C.
Flöhr,
J.
Stalljohann,
G.
Apiou-Sbirlea,
J.
Kandulla, and
R.
Brinkmann,
Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments, 2007. pp. 66321D-66321D-7.
Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments, 2007. pp. 66321D-66321D-7.
File: | 12.728222 |
Bibtex: | @inproceedings{Herrmann2007, author = {Herrmann, Katharina and Flöhr, Christian and Stalljohann, Jens and Apiou-Sbirlea, Gabriela and Kandulla, Jochen and Birngruber, Reginald and Brinkmann, Ralf}, title = {Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments}, volume = {6632}, pages = {66321D-66321D-7}, note = {10.1117/12.728222}, abstract = {In most retinal laser treatments the therapeutic effect is initiated by a transient temperature increase at and around the retinal pigment epithelium (RPE). Especially in long exposure time treatments like Transpupillary Thermotherapy (TTT) choroidal perfusion has a strong influence on the realized temperature at the fundus. The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here. In order to reduce the choroidal perfusion, the IOP is increased by injection of physiological saline solution into the eye of anaesthetized rabbits. The fundus is irradiated with 3.64 W/cm2 by means of a TTT-laser (λ = 810 nm) for t = 20 s causing a retinal temperature increase. Realtime temperature determination at the irradiated spot is achieved by a non invasive optoacoustic technique. Perfusion can be reduced by increasing IOP, which leads to different temperature increases when irradiating the retina. This should be considered for long time laser treatments.}, url = {http://dx.doi.org/10.1117/12.728222}, type = {Conference Proceedings}, year = { 2007} } |
H.
Stoehr,
L.
Ptaszynski,
A.
Fritz, and
R.
Brinkmann,
Interferometric optical online dosimetry for selective retina treatment (SRT), 2007. pp. 642619-642619-7.
Interferometric optical online dosimetry for selective retina treatment (SRT), 2007. pp. 642619-642619-7.
File: | 12.708521 |
Bibtex: | @inproceedings{Stoehr2007-1, author = {Stoehr, Hardo and Ptaszynski, Lars and Fritz, Andreas and Brinkmann, Ralf}, title = {Interferometric optical online dosimetry for selective retina treatment (SRT)}, volume = {6426}, pages = {642619-642619-7}, note = {10.1117/12.708521}, abstract = {In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.}, url = {http://dx.doi.org/10.1117/12.708521}, type = {Conference Proceedings}, Year = { 2007} } |
A
Vogel,
J.
Noack, and
G.
Paltauf,
Mechanisms of femtosecond laser nanoprocessing of biological cells and tissues, in The Eigth International Conference on Laser Ablation (COLA 2005) , Herman, P. and Hess, W ., Eds. 2007, pp. 249-254.
Mechanisms of femtosecond laser nanoprocessing of biological cells and tissues, in The Eigth International Conference on Laser Ablation (COLA 2005) , Herman, P. and Hess, W ., Eds. 2007, pp. 249-254.
A.
Vogel,
K.
Lorenz,
V.
Horneffer,
D.
Smolinski, and
A.
Gebert,
Mechanisms of laser-induced dissection and transport of histologic specimens., Biophys J , vol. 93, pp. 4481-4500, 2007.
Mechanisms of laser-induced dissection and transport of histologic specimens., Biophys J , vol. 93, pp. 4481-4500, 2007.
File: | biophysj.106.102277 |
Bibtex: | @article{Vogel2007-7, author = {Vogel, A. and Lorenz, K. and Horneffer, V. and Hüttmann, G. and von Smolinski, D. and Gebert, A.}, title = {Mechanisms of laser-induced dissection and transport of histologic specimens.}, journal = {Biophys J}, volume = {93}, pages = {4481-4500}, year = { 2007}, url = { https://doi.org/10.1529/biophysj.106.102277} } |
X.
Qu,
K.
Norbert,
Z.
Li,
J.
Wang, and
Z.
Zhang,
Multiphoton fluorescence lifetime imaging of Karpas 299 cells using ACT1 antibody conjugated gold nanoparticles, 2007. pp. 66301C-66301C-8.
Multiphoton fluorescence lifetime imaging of Karpas 299 cells using ACT1 antibody conjugated gold nanoparticles, 2007. pp. 66301C-66301C-8.
File: | 12.728239 |
Bibtex: | @inproceedings{Qu2007, author = {Qu, Xiaochao and Norbert, Koop and Li, Zheng and Wang, Jing and Zhang, Zhenxi and Hüttmann, Gereon}, title = {Multiphoton fluorescence lifetime imaging of Karpas 299 cells using ACT1 antibody conjugated gold nanoparticles}, volume = {6630}, pages = {66301C-66301C-8}, note = {10.1117/12.728239}, abstract = {Due to the unique optical properties, gold nanoparticles (NPs) can play a useful role in biological cellular imaging as biological probes. Using multiphoton microscopy and fluorescence lifetime imaging (FLIM) system, we recorded the images of Karpas 299 cells incubated without, or with gold NPs, and ACT1 antibodies conjugated with gold NPs. From the FLIM, we can easily discriminate the difference among different experiment conditions due to the distinct lifetime between cells and gold NPs. Our results present that nonconjugated gold NPs are accumulated inside cells, but conjugated gold NPs bind homogeneously and specifically to the surface of cancer cells. For single Karpas 299 cells, the signal is very week when the excitation power is about 10mw; while the power is approximately 28 mw, a very sharp cell imaging can be obtained. For the Karpas 299 incubated with ACT1 conjugated gold NPs, while the excitation power is 10mw, gold NPs have clear fluorescence signal so that the profile of cells can be detected; Signal of gold NPs is very strong when the power arrived in 20mw. These results suggest that the multiphoton lifetime imaging of antibody conjugated gold NPs can support a useful method in diagnosis of cancer.}, url = {http://dx.doi.org/10.1117/12.728239}, type = {Conference Proceedings}, year = { 2007} } |
J Kandulla,
Nicht-invasive Echtzeit-Temperaturbestimmung während Laserbehandlungen an der Netzhaut des Auges, Photonik , pp. 42-46, 2007.
Nicht-invasive Echtzeit-Temperaturbestimmung während Laserbehandlungen an der Netzhaut des Auges, Photonik , pp. 42-46, 2007.
File: | 22 |
Bibtex: | @article{Kandulla, author = {Kandulla, J and Brinkmann, R}, title = {Nicht-invasive Echtzeit-Temperaturbestimmung während Laserbehandlungen an der Netzhaut des Auges}, journal = {Photonik}, URL = { https://www.photonik.de/technologie-applikation/158/21005/22}, pages = {42-46}, year = { 2007} } |
M.
Müller,
H.
Lacqua, and
H.
Hoerauf,
Evaluation of Cyclophotocoagulation Effects with 1310-nm Contact Optical Coherence Tomography, Curr Eye Res , vol. 32, pp. 171-176, 2007.
Evaluation of Cyclophotocoagulation Effects with 1310-nm Contact Optical Coherence Tomography, Curr Eye Res , vol. 32, pp. 171-176, 2007.
M. Löning,
Physikalische Grundlagen optischer Technologien, Der Gynäkologe , vol. 40, no. 5, pp. 332-337, 2007.
Physikalische Grundlagen optischer Technologien, Der Gynäkologe , vol. 40, no. 5, pp. 332-337, 2007.
S
Tedsen, and
K
Herrmann,
Partial kidney resection by use of a 1,94 µm thulium fiber laser, in Proc ECBO , SPIE, 2007.
Partial kidney resection by use of a 1,94 µm thulium fiber laser, in Proc ECBO , SPIE, 2007.
File: | 978-3-540-68764-1_72 |
Bibtex: | @inproceedings{Theisen-Kunde2007, author = {Theisen-Kunde, D and Tedsen, S and Danicke, V and Herrmann, K and Brinkmann, R}, title = {Partial kidney resection by use of a 1,94 µm thulium fiber laser}, booktitle = {Proc ECBO}, series = {Therapeutic Laser Applications and Laser-Tissue Interactions}, publisher = {SPIE}, volume = {6632}, type = {Conference Proceedings}, year = { 2007}, url = { https://doi.org/10.1007/978-3-540-68764-1_72} } |
L.
Kranendonk,
R.
Huber,
J.
Fujimoto, and
S.
Sanders,
Wavelength-agile H2O absorption spectrometer for thermometry of general combustion gases, Proceedings of the Combustion Institute , vol. 31, no. 1, pp. 783-790, 01 2007.
Wavelength-agile H2O absorption spectrometer for thermometry of general combustion gases, Proceedings of the Combustion Institute , vol. 31, no. 1, pp. 783-790, 01 2007.
DOI: | 10.1016/j.proci.2006.08.003 |
Bibtex: | @article{KRANENDONK2007783, title = {Wavelength-agile H2O absorption spectrometer for thermometry of general combustion gases}, journal = {Proceedings of the Combustion Institute}, volume = {31}, number = {1}, pages = {783-790}, year = {2007}, issn = {1540-7489}, doi = {https://doi.org/10.1016/j.proci.2006.08.003}, url = {https://www.sciencedirect.com/science/article/pii/S1540748906002665}, author = {Laura A. Kranendonk and Robert Huber and James G. Fujimoto and Scott T. Sanders}, keywords = {Thermometry, Wavelength-agile, Absorption spectroscopy}, abstract = {Using a novel Fourier-domain mode-locking (FDML) laser scanning 1330–1380nm, we have developed a gas thermometer based on absorption spectroscopy that is appropriate for combustion gases at essentially arbitrary conditions. The path-integrated measurements are particularly useful in homogeneous environments, and here we present measurements in a controlled piston engine and a shock tube. Engine measurements demonstrate a RMS temperature precision of ±3% at 1500K and 200kHz bandwidth; the precision is improved dramatically by averaging. Initial shock tube measurements place the absolute accuracy of the thermometer within ∼2% to 1000K. The sensor performs best when significant H2O vapor is present, but requires only XH2OL>0.07cm at 300K, XH2OL>0.25cm at 1000K, or XH2OL>1.25cm at 3000K for 2% accurate thermometry, assuming a 4kHz measurement bandwidth (200kHz scans with 50 averages). The sensor also provides H2O mole fraction and shows potential for monitoring gas pressure based on the broadening of spectral features. To aid in designing other sensors based on high-temperature, high-pressure H2O absorption spectroscopy, a database of measured spectra is included.} } |
V
Ott, and
R
Keller,
Potential of a new cw 2µm laser scalpel for laparoscopic surgery, Med. Laser Appl. , vol. 22, no. 2, pp. 139-45, 2007.
Potential of a new cw 2µm laser scalpel for laparoscopic surgery, Med. Laser Appl. , vol. 22, no. 2, pp. 139-45, 2007.
Selektive Retina-Therapie (SRT), Zeitschrift für Medizinische Physik , vol. 17(1), no. 1, pp. 6-22, 2007.
DOI: | DOI 10.1016/j.zemedi.2006.11.002 |
File: | |
Bibtex: | @article{Brinkmann2007-1, author = {Brinkmann, R. and Birngruber, R.}, title = {Selektive Retina-Therapie (SRT)}, journal = {Zeitschrift für Medizinische Physik}, volume = {17(1)}, number = {1}, pages = {6-22}, note = {276HP Times Cited:0 Cited References Count:42}, abstract = {Selective Retina Therapy (SRT) is a new and very gentle laser method developed at the Medical Laser Center Lubeck. It is currently investigated clinically in order to treat retinal disorders associated with a decreased function of the retinal pigment epithelium (RPE). SRT is designed to selectively effect the RPE while sparing the neural retina and the photoreceptors as well as the chorioidea. Aim of the therapy is the rejuvenation of the RPE in the treated areas, which should ideally lead to a long term metabolic increase at the chorio- retinal junction. In contrast to conventional laser photocoagulation, which is associated with a complete thermal necrosis of the treated site, SRT completely retains full vision. This paper reviews the methods and mechanisms behind selective RPE effects and reports the first clinical results. An online dosimetry technique to visualize the ophthalmoscopically invisible effects is introduced.}, keywords = {selective cellular effects optoacoustics online dosimetry rpe mu s-laser pulses macula oedema rcs pigment epithelium diabetic maculopathy laser irradiation time regimen damage rpe photocoagulation absorption mechanisms radiation}, ISSN = {0939-3889}, DOI = {DOI 10.1016/j.zemedi.2006.11.002}, url = {<Go to ISI>://WOS:000254132200002}, year = { 2007}, url = { https://pubmed.ncbi.nlm.nih.gov/17549989/}, type = {Journal Article} } |
J
Stalljohann,
B
Weber,
K
Schlott, and
J
Kandulla,
Retinal Temperature Determination During Laser Photocoagulation, Proc SPIE , vol. 6632, pp. 8, 2007.
Retinal Temperature Determination During Laser Photocoagulation, Proc SPIE , vol. 6632, pp. 8, 2007.
A
Vogel,
V.
Horneffer,
B.
Lorenz,
N.
Linz,
S.
Freidank, and
A.
Gebert,
Principles of laser microdissection and catapulting of histologic specimens and live cells, in Laser Manipulation of Cells and Tissues, Methods in Cell Biology , Berns, M. and Greulich, K.O., Eds. San Diego: Academic Press Elsevier, 2007, pp. 153-205.
Principles of laser microdissection and catapulting of histologic specimens and live cells, in Laser Manipulation of Cells and Tissues, Methods in Cell Biology , Berns, M. and Greulich, K.O., Eds. San Diego: Academic Press Elsevier, 2007, pp. 153-205.
K.
Schlott,
J.
Stalljohann,
B.
Weber,
J.
Kandulla,
K.
Herrmann, and
R.
Brinkmann,
Optoacoustic online temperature determination during retinal laser photocoagulation, 2007. pp. 66321B-66321B-8.
Optoacoustic online temperature determination during retinal laser photocoagulation, 2007. pp. 66321B-66321B-8.
File: | 12.728291 |
Bibtex: | @inproceedings{Schlott2007, author = {Schlott, Kerstin and Stalljohann, Jens and Weber, Benjamin and Kandulla, Jochen and Herrmann, Katharina and Birngruber, Reginald and Brinkmann, Ralf}, title = {Optoacoustic online temperature determination during retinal laser photocoagulation}, volume = {6632}, pages = {66321B-66321B-8}, note = {10.1117/12.728291}, abstract = {Retinal photocoagulation is an established treatment of different retinal diseases. The treatment relies on a short, local heating of the tissue which induces a denaturation. The resulting scar formation may for example prevent the further detachment of the retina. The extent of the coagulation is besides other parameters mostly dependent on the induced temperature increase. However, until today a temperature based dosimetry for photocoagulation does not exist. The dosage is rather based on the experience of the treating physicians to achieve visible whitish lesions on the retina. In this work a technique is presented, which allows an online temperature monitoring during photocoagulation. If an absorbing material is irradiated with short laser pulses, a thermoelastic expansion of the absorber induces an acoustic wave. Its amplitude is dependent on the temperature of the absorber. For analyzing the applicability of the optoacoustic temperature determination for dosimetry, measurements were performed on enucleated porcine eye globes. The pressure transients are detected by an ultrasonic transducer, which is embedded in an ophthalmologic contact lens. As long as no strong lesions occur, the determined temperatures are almost proportional to the power of the treatment laser. Using a spot diameter of 200 μm and different laser powers, the temperature rise at the end of the 400 ms irradiation was found to be approximately 0.16 °C/mW. The onset of the denaturation was observed around 50°C. The far aim of this project is an automatic regulation of the treatment laser onto a desired temperature course.}, url = {http://dx.doi.org/10.1117/12.728291}, type = {Conference Proceedings}, year = { 2007} } |
P.
Steven,
J.
Rupp,
G.
Huettmann,
N.
Koop, and
H.
Laqua,
Two-Photon Real-Time Imaging of Conjunctiva-Associated Lymphoid Tissue (CALT), Investigative Ophthalmology & Visual Science , vol. 48, no. 13, pp. 201-201, 2007.
Two-Photon Real-Time Imaging of Conjunctiva-Associated Lymphoid Tissue (CALT), Investigative Ophthalmology & Visual Science , vol. 48, no. 13, pp. 201-201, 2007.
C.
Framme,
C.
Alt,
S.
Schnell,
M.
Sherwood, and
C.
Lin,
Selective targeting of the retinal pigment epithelium in rabbit eyes with a scanning laser beam, Invest Ophthalmol Vis Sci , vol. 48, no. 4, pp. 1782-92, 2007.
Selective targeting of the retinal pigment epithelium in rabbit eyes with a scanning laser beam, Invest Ophthalmol Vis Sci , vol. 48, no. 4, pp. 1782-92, 2007.
Selective Retina Therapy (SRT), Z Med Phys , vol. 17, no. 1, pp. 6-22, 2007.
V.
Horneffer,
N.
Linz, and
A.
Vogel,
Principles of laser-induced separation and transport of living cells, J Biomed Opt , vol. 12, no. 5, pp. 054016, 2007.
Principles of laser-induced separation and transport of living cells, J Biomed Opt , vol. 12, no. 5, pp. 054016, 2007.
A
Ramrath, and
A
Schweikard,
Towards Automated OCT-based Identification of White Brain Matter, in Bildverarbeitung für die Medizin 2007 , Horsch, Alexander and Deserno, ThomasM and Handels, Heinz and Meinzer, Hans-Peter and Tolxdorff, Thomas, Eds. Springer Berlin Heidelberg, 2007, pp. 414-418.
Towards Automated OCT-based Identification of White Brain Matter, in Bildverarbeitung für die Medizin 2007 , Horsch, Alexander and Deserno, ThomasM and Handels, Heinz and Meinzer, Hans-Peter and Tolxdorff, Thomas, Eds. Springer Berlin Heidelberg, 2007, pp. 414-418.
2006
R.
Huber,
D.
Adler, and
J.
Fujimoto,
Buffered Fourier domain mode locking: unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s, Opt. Lett. , vol. 31, no. 20, pp. 2975-2977, Oct. 2006. Optica Publishing Group.
Buffered Fourier domain mode locking: unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s, Opt. Lett. , vol. 31, no. 20, pp. 2975-2977, Oct. 2006. Optica Publishing Group.
DOI: | 10.1364/OL.31.002975 |
Bibtex: | @article{Huber:06, author = {Robert Huber and Desmond C. Adler and James G. Fujimoto}, journal = {Opt. Lett.}, keywords = {Optical coherence tomography; Lasers, tunable; Amplified spontaneous emission; Fourier domain mode locking; Image quality; Laser sources; Optical coherence tomography; Swept sources}, number = {20}, pages = {2975--2977}, publisher = {Optica Publishing Group}, title = {Buffered Fourier domain mode locking: unidirectional swept laser sources for optical coherence tomography imaging at 370,000 lines/s}, volume = {31}, month = {Oct}, year = {2006}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-31-20-2975}, doi = {10.1364/OL.31.002975}, abstract = {We describe buffered Fourier domain mode locking (FDML), a technique for tailoring the output and multiplying the sweep rate of FDML lasers. Buffered FDML can be used to create unidirectional wavelength sweeps from the normal bidirectional sweeps in an FDML laser without sacrificing sweep rate. We also investigate the role of the laser source in dynamic range versus sensitivity performance in optical coherence tomography (OCT) imaging. Unidirectional sweep rates of 370 kHz over a 100 nm range at a center wavelength of 1300 nm are achieved. High-speed, swept-source OCT is demonstrated at record speeds of up to 370,000 axial scans per second.}, } |
M.
Lenz,
R.
Huber,
B.
Schmidt,
P.
Gilch,
R.
Kalmbach,
M.
Engelhard, and
J.
Wachtveitl,
First steps of retinal photoisomerization in proteorhodopsin, Biophysical Journal , vol. 91, no. 1, pp. 255-262, 07 2006.
First steps of retinal photoisomerization in proteorhodopsin, Biophysical Journal , vol. 91, no. 1, pp. 255-262, 07 2006.
DOI: | 10.1529/biophysj.105.074690 |
Bibtex: | @article{LENZ2006255, title = {First Steps of Retinal Photoisomerization in Proteorhodopsin}, journal = {Biophysical Journal}, volume = {91}, number = {1}, pages = {255-262}, year = {2006}, issn = {0006-3495}, doi = {https://doi.org/10.1529/biophysj.105.074690}, url = {https://www.sciencedirect.com/science/article/pii/S0006349506717258}, author = {Martin O. Lenz and Robert Huber and Bernhard Schmidt and Peter Gilch and Rolf Kalmbach and Martin Engelhard and Josef Wachtveitl}, abstract = {The early steps (<1ns) in the photocycle of the detergent solubilized proton pump proteorhodopsin are analyzed by ultrafast spectroscopic techniques. A comparison to the first primary events in reconstituted proteorhodopsin as well as to the well known archaeal proton pump bacteriorhodopsin is given. A dynamic Stokes shift observed in fs-time-resolved fluorescence experiments allows a direct observation of early motions on the excited state potential energy surface. The initial dynamics is dominated by sequentially emerging stretching (<150fs) and torsional (∼300fs) modes of the retinal. The different protonation states of the primary proton acceptor Asp-97 drastically affect the reaction rate and the overall quantum efficiencies of the isomerization reactions, mainly evidenced for time scales above 1ps. However, no major influence on the fast time scales (∼150fs) could be seen, indicating that the movement out of the Franck-Condon region is fairly robust to electrostatic changes in the retinal binding pocket. Based on fs-time-resolved absorption and fluorescence spectra, ground and exited state contributions can be disentangled and allow to construct a reaction model that consistently explains pH-dependent effects in solubilized and reconstituted proteorhodopsin.} } |
R.
Huber,
M.
Wojtkowski, and
J.
Fujimoto,
Fourier domain mode locking (FDML): Three-dimensional OCT imaging at 906 frames per second, in 2006 Conference on Lasers and Electro-Optics and 2006 Quantum Electronics and Laser Science Conference , IEEE, 052006. pp. 1-2.
Fourier domain mode locking (FDML): Three-dimensional OCT imaging at 906 frames per second, in 2006 Conference on Lasers and Electro-Optics and 2006 Quantum Electronics and Laser Science Conference , IEEE, 052006. pp. 1-2.
DOI: | 10.1109/CLEO.2006.4627914 |
Bibtex: | @INPROCEEDINGS{4627914, author={Huber, R. and Wojtkowski, M. and Fujimoto, J. G.}, booktitle={2006 Conference on Lasers and Electro-Optics and 2006 Quantum Electronics and Laser Science Conference}, title={Fourier Domain Mode Locking (FDML): Three-dimensional OCT imaging at 906 frames per second}, year={2006}, volume={}, number={}, pages={1-2}, abstract={Fourier domain mode locking is a new operation regime of lasers. Highly chirped frequency swept waveforms rather than short pulses are generated. The mechanism and its application for ultrahigh-speed biomedical OCT imaging are discussed.}, keywords={}, doi={10.1109/CLEO.2006.4627914}, ISSN={2160-9004}, month={May},} |
R.
Huber,
M.
Wojtkowski, and
J.
Fujimoto,
Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography, Optics Express , vol. 14, no. 8, pp. 3225 - 3237, 04 2006.
Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography, Optics Express , vol. 14, no. 8, pp. 3225 - 3237, 04 2006.
DOI: | 10.1364/OE.14.003225 |
Bibtex: | @article{Huber:06, author = {R. Huber and M. Wojtkowski and J. G. Fujimoto}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Frequency modulated lasers; Full field optical coherence tomography; Laser operation; Light fields; Medical imaging; Mode locking}, number = {8}, pages = {3225--3237}, publisher = {Optica Publishing Group}, title = {Fourier Domain Mode Locking (FDML): A new laser operating regime and applications for optical coherence tomography}, volume = {14}, month = {Apr}, year = {2006}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-14-8-3225}, doi = {10.1364/OE.14.003225}, abstract = {We demonstrate a new technique for frequency-swept laser operation--Fourier domain mode locking (FDML)--and its application for swept-source optical coherence tomography (OCT) imaging. FDML is analogous to active laser mode locking for short pulse generation, except that the spectrum rather than the amplitude of the light field is modulated. High-speed, narrowband optical frequency sweeps are generated with a repetition period equal to the fundamental or a harmonic of cavity round-trip time. An FDML laser is constructed using a long fiber ring cavity, a semiconductor optical amplifier, and a tunable fiber Fabry-Perot filter. Effective sweep rates of up to 290 kHz are demonstrated with a 105 nm tuning range at 1300 nm center wavelength. The average output power is 3 mW directly from the laser and 20 mW after post-amplification. Using the FDML laser for swept-source OCT, sensitivities of 108 dB are achieved and dynamic linewidths are narrow enough to enable imaging over a 7 mm depth with only a 7.5 dB decrease in sensitivity. We demonstrate swept-source OCT imaging with acquisition rates of up to 232,000 axial scans per second. This corresponds to 906 frames/second with 256 transverse pixel images, and 3.5 volumes/second with a 256{\texttimes}128{\texttimes}256 voxel element 3-D OCT data set. The FDML laser is ideal for swept-source OCT imaging, thus enabling high imaging speeds and large imaging depths.}, } |
L.
Kranendonk,
J.
Walewski,
S.
Sanders, and
R.
Huber,
"Measurements of Gas Temperature in a HCCI Engine Using a Fourier Domain Mode Locking Laser" SAE Technical Paper 2006-01-1366, 04 2006.
"Measurements of Gas Temperature in a HCCI Engine Using a Fourier Domain Mode Locking Laser" SAE Technical Paper 2006-01-1366, 04 2006.
DOI: | 10.4271/2006-01-1366 |
Bibtex: | @TechReport{HU_2006_Kranendonk_a, Title = {{Measurements of Gas Temperature in a HCCI Engine Using a Fourier Domain Mode Locking Laser}}, Author = {Kranendonk, Laura A and Walewski, Joachim W and Sanders, Scott T and Huber, Robert and Fujimoto, James G}, Year = {2006}, Month = apr, pages = {1366 1--5}, Doi = {10.4271/2006-01-1366}, keywords = {AG-Huber_FDML, AG-Huber_OCT}, Url = {http://www.sae.org/technical/papers/2006-01-1366} } |
K.
Taira,
R.
Huber,
M.
Wojtkowski, and
J.
Fujimoto,
Fourier domain mode-locked lasers for swept source OCT imaging at up to 290 kHz scan rates, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X , Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 022006. pp. 60790U.
Fourier domain mode-locked lasers for swept source OCT imaging at up to 290 kHz scan rates, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X , Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 022006. pp. 60790U.
DOI: | 10.1117/12.648880 |
Bibtex: | @inproceedings{10.1117/12.648880, author = {R. Huber and K. Taira and M. Wojtkowski and J. G. Fujimoto}, title = {{Fourier domain mode-locked lasers for swept source OCT imaging at up to 290 kHz scan rates}}, volume = {6079}, booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X}, editor = {Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {60790U}, abstract = {A new type of laser operation, Fourier Domain Mode Locking (FDML), is demonstrated for high performance, frequency swept light sources. FDML achieves superior sweep speeds, coherence lengths and bandwidths compared to standard bulk or fiber lasers. At 1300 nm a sweep range up to 145 nm, up to 4 cm delay length, and sweep rates up to 290 kHz were achieved. This light source is demonstrated for swept source OCT imaging.}, keywords = {Fourier Domain Mode Locking, swept laser, tunable laser, wavelength agile, optical coherence tomography, spectral domain, Fourier domain, fiber laser}, year = {2006}, doi = {10.1117/12.648880}, URL = {https://doi.org/10.1117/12.648880} } |
L.
Kranendonk,
J.
Walewski,
S.
Sanders,
R.
Huber, and
J.
Fujimoto,
Measurements of Gas Temperature in an HCCI Engine by Use of a Fourier-Domain Mode-Locking Laser, in Laser Applilcations to Chemical, Security and Environmental Analysis , Optica Publishing Group, 022006. pp. TuB2.
Measurements of Gas Temperature in an HCCI Engine by Use of a Fourier-Domain Mode-Locking Laser, in Laser Applilcations to Chemical, Security and Environmental Analysis , Optica Publishing Group, 022006. pp. TuB2.
DOI: | 10.1364/LACSEA.2006.TuB2 |
Bibtex: | @inproceedings{Kranendonk:06, author = {Laura A. Kranendonk and Joachim W. Walewski and Scott T. Sanders and Robert Huber and James G. Fujimoto}, booktitle = {Laser Applilcations to Chemical, Security and Environmental Analysis}, journal = {Laser Applilcations to Chemical, Security and Environmental Analysis}, keywords = {Lasers and laser optics; Diode lasers; Lasers, tunable; Laser operation; Laser sensors; Lasers; Mode locking; Spontaneous emission; Tunable diode lasers}, pages = {TuB2}, publisher = {Optica Publishing Group}, title = {Measurements of gas temperature in an HCCI engine by use of a Fourier-domain mode-locking laser}, year = {2006}, url = {https://opg.optica.org/abstract.cfm?URI=LACSEA-2006-TuB2}, doi = {10.1364/LACSEA.2006.TuB2}, abstract = {Initial measurements of water vapor temperature by use of a Fourier-domain mode-locking laser were performed in a homogenous charge compression ignition engine. We assessed the potential of this FDML laser in combustion applications.}, } |
S
Tamaoki,
Y
Hayashi,
H
Sakaguchi,
N
Tanaka,
M
Ota,
T
Yokoyama, and
K
Shiraki,
Retinoblastoma in the patient with 13q-syndrome: a report of two cases., Japanese Review of Clinical Ophthalmology , vol. 100, no. 8, pp. 587-590, 2006.
Retinoblastoma in the patient with 13q-syndrome: a report of two cases., Japanese Review of Clinical Ophthalmology , vol. 100, no. 8, pp. 587-590, 2006.
A.
Vogel,
I.
Apitz,
S.
Freidank, and
R.
Dijkink,
Sensitive high-resolution white-light Schlieren technique with a large dynamic range for the investigation of ablation dynamics, Opt. Lett. , vol. 31, pp. 1812-1814, 2006.
Sensitive high-resolution white-light Schlieren technique with a large dynamic range for the investigation of ablation dynamics, Opt. Lett. , vol. 31, pp. 1812-1814, 2006.
File: | OL.31.001812 |
Bibtex: | @article{Vogel2006-1, author = {Vogel, A. and Apitz, I. and Freidank, S. and Dijkink, R.}, title = {Sensitive high-resolution white-light Schlieren technique with a large dynamic range for the investigation of ablation dynamics}, journal = {Opt. Lett.}, volume = {31}, pages = {1812-1814}, year = { 2006}, url = { https://doi.org/10.1364/OL.31.001812} } |
G.
Schuele,
J.
Neumann,
C.
Framme,
E.
Pörkensen,
H.
Elsner, and
J.
Roider,
Selektive Retina Therapie - Methodik, Technik und Online-Dosimetrie, Ophthalmologe , vol. 103, pp. 839-849, 2006.
Selektive Retina Therapie - Methodik, Technik und Online-Dosimetrie, Ophthalmologe , vol. 103, pp. 839-849, 2006.
J
Kandulla,
H
Elsner, and
J
Sandeau,
Non-invasive optoacoustic temperature determination during retinal cw-laser treatments, in Proc SPIE , 2006. pp. 336-343.
Non-invasive optoacoustic temperature determination during retinal cw-laser treatments, in Proc SPIE , 2006. pp. 336-343.
File: | 12.674409 |
Bibtex: | @inproceedings{Kandulla2006, author = {Kandulla, J and Elsner, H and Sandeau, J and Birngruber, R and Brinkmann, R}, title = {Non-invasive optoacoustic temperature determination during retinal cw-laser treatments}, booktitle = {Proc SPIE}, volume = {6138}, pages = {336-343}, type = {Conference Proceedings}, year = { 2006}, url = { https://doi.org/10.1117/12.674409} } |
A.
Giese,
H.
Böhringer,
J.
Leppert,
S.
Kandelhardt,
E.
Lankenau, and
P.
Koch,
Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors., Proc SPIE , vol. 6078, pp. 495-502, 2006.
Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors., Proc SPIE , vol. 6078, pp. 495-502, 2006.
File: | 12.674436.short |
Bibtex: | @article{Giese2006, author = {Giese, A. and Böhringer, H.J. and Leppert, J. and Kandelhardt, S.R. and Lankenau, E. and Koch, P. and Birngruber, R. and Hüttmann, G.}, title = {Non-invasive intraoperative optical coherence tomography of the resection cavity during surgery of intrinsic brain tumors.}, journal = {Proc SPIE}, volume = {6078}, pages = {495-502}, year = { 2006}, url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/6078/60782Z/Non-invasive-intraoperative-optical-coherence-tomography-of-the-resection-cavity/10.1117/12.674436.short}, type = {Proceeding} } |
J.
Sandeau,
G.
Caillibotte,
J.
Kandulla, and
G.
Apiou-Sbirlea,
Modeling of conductive and convective heat transfers in retinal laser treatments, 2006. pp. 61381A-61381A-9.
Modeling of conductive and convective heat transfers in retinal laser treatments, 2006. pp. 61381A-61381A-9.
File: | 12.673494 |
Bibtex: | @inproceedings{Sandeau2006, author = {Sandeau, Julien and Caillibotte, Georges and Kandulla, Jochen and Birngruber, Reginald and Apiou-Sbirlea, Gabriela}, title = {Modeling of conductive and convective heat transfers in retinal laser treatments}, volume = {6138}, pages = {61381A-61381A-9}, note = {10.1117/12.673494}, abstract = {Tumor thermo treatment such as photodynamic therapy (PDT) or transpupillary thermotherapy (TTT) deal with long term and large laser spot exposures. The induced temperature increase is not exactly known [1]. Under these conditions convective heat transfers due to the blood flow in the choroid and the choriocapillaris must be considered in addition to the usually calculated heat conduction. From an existing analytical model defining a unique convective term for the whole fundus irradiated with Gaussian irradiance distribution lasers [2], we developed a numerical one allowing a precise modelling of convection and calculating heating evolution and temperature profiles of the fundus of the eye. The aim of this study is to present the modelling and several comparisons between experimental results [3] and numerical ones concerning the convective heat transfers inside the fundus of the eye.}, url = {http://dx.doi.org/10.1117/12.673494}, type = {Conference Proceedings}, year = { 2006} } |
A.
Vogel,
J.
Noack,
N.
Linz,
S.
Freidank, and
G.
Paltauf,
Femtosecond laser nanosurgery of biological cells and tissues, in 4th International Congress on Laser Advanced Materials Processing , 2006.
Femtosecond laser nanosurgery of biological cells and tissues, in 4th International Congress on Laser Advanced Materials Processing , 2006.
File: | download |
Bibtex: | @inproceedings{Vogel-2006, author = {Vogel, A. and Noack, J. and Hüttmann, G. and Linz, N. and Freidank, S. and Paltauf, G.}, title = {Femtosecond laser nanosurgery of biological cells and tissues}, booktitle = {4th International Congress on Laser Advanced Materials Processing}, Year = { 2006}, URL = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.713.4169&rep=rep1&type=pdf} } |
A.
Vogel,
J
Noack, and
G.
Paltauf,
Femtosecond plasma-mediated nanosurgery of cells and tissues., in Laser Ablation , ), Phipps C (Hrsg., Eds. Springer, Heidelberg, 2006, pp. 217-262.
Femtosecond plasma-mediated nanosurgery of cells and tissues., in Laser Ablation , ), Phipps C (Hrsg., Eds. Springer, Heidelberg, 2006, pp. 217-262.
R
Tanaka,
Y
Hayashi,
T
Kohno,
K
Yamazaki, and
K
Shiraki,
Retinal phlebitis in a case of erythema induratum of Bazin, Japanese Journal of Clinical Ophthalmology , vol. 60, no. 12, pp. 1901-1904, 2006.
Retinal phlebitis in a case of erythema induratum of Bazin, Japanese Journal of Clinical Ophthalmology , vol. 60, no. 12, pp. 1901-1904, 2006.
H.
Diddens,
N.
Arp, and
W.
Eisenbeiß,
Photodynamische Therapie zur Behandlung lokaler Wunden, GMS Krankenhaushyg Interdiszip , vol. 1, no. 1, pp. Doc 19, 2006.
Photodynamische Therapie zur Behandlung lokaler Wunden, GMS Krankenhaushyg Interdiszip , vol. 1, no. 1, pp. Doc 19, 2006.
S
Ueda,
Y
Hayashi,
T
Kohno,
N
Miki,
E
Hishida, and
K
Shiraki,
A case of pachymeningitis with impaired ocular motility., Japanese Journal of Clinical Ophthalmology , vol. 60, no. 4, pp. 553-557, 2006.
A case of pachymeningitis with impaired ocular motility., Japanese Journal of Clinical Ophthalmology , vol. 60, no. 4, pp. 553-557, 2006.
E
Hishida,
Y.
Hayashi,
T
Narumi, and
K.
Shiraki,
A case of Tolosa-Hunt syndrome with optic neuritis and impaired visual acuity, Japanese Journal of Clinical Ophthalmology , vol. 60, no. 6, pp. 943-946, 2006.
A case of Tolosa-Hunt syndrome with optic neuritis and impaired visual acuity, Japanese Journal of Clinical Ophthalmology , vol. 60, no. 6, pp. 943-946, 2006.
D. Daniltchenko,
Anwendung der optischen Kohärenztomographie (OCT) bei der Darstellung von Urothelerkrankungen der Harnblase, Der Radiologe , vol. 46, no. 7, pp. 584, 2006.
Anwendung der optischen Kohärenztomographie (OCT) bei der Darstellung von Urothelerkrankungen der Harnblase, Der Radiologe , vol. 46, no. 7, pp. 584, 2006.
T
Narumi,
Y
Hayashi,
S
Ataka,
R
Tanaka,
M
Murasawa,
T
Kohno, and
K
Shiraki,
Blunt ocular trauma in a patient with hemophilia-A, Japanese Journal of Clinical Ophthalmology , vol. 60, no. 9, pp. 1653-1656, 2006.
Blunt ocular trauma in a patient with hemophilia-A, Japanese Journal of Clinical Ophthalmology , vol. 60, no. 9, pp. 1653-1656, 2006.
J. Neumann,
Cell disintegration by laser-induced transient microbubbles and its simultaneous monitoring by interferometry, Journal of Biomedical Optics , vol. 11, no. 4, pp. 041112-1 - 041112-11, 2006.
Cell disintegration by laser-induced transient microbubbles and its simultaneous monitoring by interferometry, Journal of Biomedical Optics , vol. 11, no. 4, pp. 041112-1 - 041112-11, 2006.
C.
Framme, and
B.
Flucke,
Comparison of reduced and standard light application in photodynamic therapy of the eye in two rabbit models, Graefes Arch Clin Exp Ophthalmol , vol. 244, no. 7, pp. 773-81, 2006.
Comparison of reduced and standard light application in photodynamic therapy of the eye in two rabbit models, Graefes Arch Clin Exp Ophthalmol , vol. 244, no. 7, pp. 773-81, 2006.
File: | query.fcgi |
Bibtex: | @article{Famme2006, author = {Framme, C. and Flucke, B. and Birngruber, R.}, title = {Comparison of reduced and standard light application in photodynamic therapy of the eye in two rabbit models}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {244}, number = {7}, pages = {773-81}, note = {0721-832X (Print) Comparative Study Journal Article}, abstract = {BACKGROUND: Current PDT treatment for age-related macular degeneration uses a standard radiant exposure of 50 J/cm(2) at an irradiance of 600 mW/cm(2). However; there is a general problem with the unusually high irradiance; in fact, the rate of photochemical production of singlet oxygen may be limited by insufficiently oxygenized neovascular tissue. It was the aim of this study to evaluate the efficacy of verteporfin (Visudyne) photoactivation to induce thrombosis of choriocapillaries and in experimentally induced corneal neovascularizations in rabbits by varying irradiance and retinal radiant exposure. MATERIALS AND METHODS: The light-dose threshold to induce micro-thrombosis in the choriocapillaries (seven eyes) and in corneal neovascularizations (eight eyes) of Chinchilla-Bastard rabbits using different retinal irradiances (100 and 600 mW/cm(2)) at different radiant exposures (20, 10, 5, 2.5, 1.25, 0.62, and 0.3 J/cm(2)) was evaluated. Induction of neovascularizations was performed 7 days prior to PDT treatment using intracorneal silk sutures. A dose of 2 mg/kg verteporfin was intravenously infused 10 min before standard PDT. The criterion for vascular thrombosis was vessel closure as determined by fluorescein angiography 1 h and 1 day post exposure. RESULTS: Experiments on the choroid revealed vessel closure 1 h after irradiation at ED(50) = 10.8 J/cm(2) (both 600 and 100 mW/cm(2)) and after 24 h at ED(50) = 2.4 J/cm(2) (600 mW/cm(2)) versus 1.8 J/cm(2) (100 mW/cm(2)). Vessel closure was enhanced at irradiation with 100 mW/cm(2). Regarding corneal neovascularizations, vessel thrombosis was observable by dark appearance of irradiated clotted neovascular tissue and angiographically by a lack of leakage at ED(50) thresholds of 0.62 J/cm(2) (1 h) and 0.41 J/cm(2) (1 day) for 100 mW/cm(2) and of 0.99 J/cm(2) (1 h), and 0.67 J/cm(2) (1 day) for 600 mW/cm(2). Thus in both experiments thresholds for vessel closure were reduced by a factor of 1.5 for the lower intensity. Histology revealed more selective vessel occlusion without RPE and photoreceptor damage for 100 mW/cm(2) rather than 600 mW/cm(2) intensity at threshold irradiation. CONCLUSION: Low-intensity PDT with verteporfin for neovascular tissue seems to be more effective than regular high-intensity PDT. Future preclinical trials should address the issue of proper dosimetry for effective PDT in age-related macular degeneration.}, keywords = {Animals Choroidal Neovascularization/*drug therapy Corneal Neovascularization/*drug therapy *Disease Models, Animal Fluorescein Angiography Photochemotherapy/*methods Photosensitizing Agents/*therapeutic use Porphyrins/*therapeutic use Rabbits Radiation Dosage}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16440207}, year = {2006}, type = {Journal Article} } |
C.
Framme,
H.
Sachs, and
B.
Flucke,
Evaluation of the new photosensitizer Tookad (WST09) for photodynamic vessel occlusion of the choroidal tissue in rabbits, Invest Ophthalmol Vis Sci , vol. 47, no. 12, pp. 5437-46, 2006.
Evaluation of the new photosensitizer Tookad (WST09) for photodynamic vessel occlusion of the choroidal tissue in rabbits, Invest Ophthalmol Vis Sci , vol. 47, no. 12, pp. 5437-46, 2006.
File: | query.fcgi |
Bibtex: | @article{Framme2006, author = {Framme, C. and Sachs, H. G. and Flucke, B. and Theisen-Kunde, D. and Birngruber, R.}, title = {Evaluation of the new photosensitizer Tookad (WST09) for photodynamic vessel occlusion of the choroidal tissue in rabbits}, journal = {Invest Ophthalmol Vis Sci}, volume = {47}, number = {12}, pages = {5437-46}, note = {0146-0404 (Print) Journal Article Research Support, Non-U.S. Gov't}, abstract = {PURPOSE: To determine the efficacy of Tookad (WST09; Negma-Lerads, Magny-Les-Hameaux, France) photodynamic therapy (T-PDT) by evaluating the angiographic and histologic closure of choroidal vessels at different radiance exposures, drug dosages, and intervals between photosensitizer injection and laser application in a rabbit model. METHODS: Chinchilla Bastard rabbits were injected intravenously with three different dye concentrations (2.5, 5, and 10 mg/kg) before application of light. In every group T-PDT was performed at four different times after injection: 5, 15, 30, and 60 minutes with different radiance exposures ranging from 200 to 3 J/cm2. Fundus photographs and fluorescein angiograms were obtained 90 minutes after injection. Follow-up angiographies were performed at days 1, 3, 7, and 14 after initial treatment. Histology was performed in selected cases immediately after treatment and on days 1, 3, and 7. RESULTS: Immediately after irradiation, most of the visible lesions were angiographically hyperfluorescent due to damaged vessel endothelium and associated RPE damage. Lesions from high-radiance exposures revealed immediate hypofluorescence, indicating vessel closure. Hypofluorescent lesions appeared mainly during day 1 (all lesions angiographically visible, some hypofluorescent) to day 3 (all lesions hypofluorescent) after treatment. At day 7, ophthalmoscopically visible hyperpigmentation took place in all lesions. ED50 thresholds for angiographic hypofluorescence determined at day 3 after treatment with 2.5 mg/kg were 18.8 J/cm2 (5 minutes), 62.0 J/cm2 (15 minutes), and >100 J/cm2 (30 minutes); with 5 mg/kg, 8.4 J/cm2 (5 minutes), 22.8 J/cm2 (15 minutes), 54.5 J/cm2 (30 minutes), and >100 J/cm2 (60 minutes); and with 10 mg/kg, 11.7 J/cm2 (30 minutes) and 54.1 J/cm2 (60 minutes). Histology of the angiographically hypofluorescent lesions revealed vessel thrombosis in all groups 1 hour after PDT up to 7 days after treatment. Sparing of photoreceptors indicated selectivity of T-PDT; however, slight damage was partly observable. After 7 days, localized proliferation of the RPE cells was noted and was enhanced 14 days after treatment. CONCLUSIONS: T-PDT has the potential to achieve selective choroidal vessel occlusion with proper parameter selection, such as (1) 2.5 mg/kg, 5 minutes, 100 J/cm2; (2) 5 mg/kg, 5 minutes, 25 J/cm2; or (3) 5 mg/kg, 15 minutes, 50 J/cm2; however, slight damage to the photoreceptors cannot be ruled out. RPE proliferation indicates primary RPE damage due to PDT, also described with the use of all other photosensitizers.}, keywords = {Animals Bacteriochlorophylls/*administration & dosage Choroid/*blood supply/drug effects/pathology Choroidal Neovascularization/diagnosis/*drug therapy Drug Evaluation, Preclinical Fluorescein Angiography *Photochemotherapy Photosensitizing Agents/*administration & dosage Rabbits}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17122134}, year = {2006}, type = {Journal Article} } |
M.
Müller,
H.
Hoerauf,
G.
Geerling,
S.
Pape, and
H.
Laqua,
Filtering bleb evaluation with slit-lamp-adapted 1310-nm optical coherence tomography, Current Eye Research , vol. 31, no. 11, pp. 909-915, 2006.
Filtering bleb evaluation with slit-lamp-adapted 1310-nm optical coherence tomography, Current Eye Research , vol. 31, no. 11, pp. 909-915, 2006.
DOI: | Doi 10.1080/02713680600910528 |
File: | WOS:000242142000003 |
Bibtex: | @article{Müller2006, author = {Muller, M. and Hoerauf, H. and Geerling, G. and Pape, S. and Winter, C. and Huttmann, G. and Birngruber, R. and Laqua, H.}, title = {Filtering bleb evaluation with slit-lamp-adapted 1310-nm optical coherence tomography}, journal = {Current Eye Research}, volume = {31}, number = {11}, pages = {909-915}, note = {107AB Times Cited:24 Cited References Count:27}, abstract = {Purpose: Investigation of slit-lamp-adapted 1310-nm optical coherence tomography (OCT) as an in vivo imaging device in the postoperative course of glaucoma surgery. Methods: Postoperative images of filtering blebs and deep sclerectomies and their healing processes were qualitatively evaluated with a slit-lamp-adapted anterior segment OCT (AS-OCT; Heidelberg Engineering, Heidelberg, Germany) in 28 patients. Ophthalmologic examinations included slit-lamp examination, applanation tonometry, and slit-lamp photography. The OCT scans were qualitatively correlated with the morphologic and functional outcome of the filtering bleb. Results: 1310-nm OCT was able to demonstrate the internal structure and the dimensions of filtering blebs, as well as the scleral flap and the deep sclerectomy location including Descemet membrane. Functioning filtering blebs showed a low OCT signal, small fluid-filled cysts, superficial microcystic layer, and a slack internal texture. High internal reflectivity indicated an earlier scarring of the filtering bleb. Nonfunctioning filtering blebs delivered a high OCT signal, no or few cysts, and a dense internal texture. These different OCT patterns correlated with the clinical outcome. Conclusions: Slit-lamp-adapted 1310-nm OCT allowed the noncontact observation and documentation of the postoperative healing course of filtering blebs after glaucoma surgery. Internal structures of the filtering bleb and deep sclerectomies could be visualized. Functioning and dysfunctioning filtering blebs delivered different OCT pattern and correlated with the clinical outcome. This could be a new way to assess the postoperative healing process with the possibility of earlier intervention in cases of impending scarring.}, keywords = {deep sclerectomy filtering bleb oct scarring anterior segment mitomycin-c follow-up trabeculectomy surgery cornea eye}, ISSN = {0271-3683}, DOI = {Doi 10.1080/02713680600910528}, url = {<Go to ISI>://WOS:000242142000003}, year = {2006}, type = {Journal Article} } |
M.
Müller,
H.
Hoerauf,
G.
Geerling,
S.
Pape, and
H.
Laqua,
Filtring Bleb Evaluation with Slit-Lamp-Adapted 1310-nm Optical Coherence Tomography, Curr Eye Res , vol. 31, no. 11, pp. 909-915, 2006.
Filtring Bleb Evaluation with Slit-Lamp-Adapted 1310-nm Optical Coherence Tomography, Curr Eye Res , vol. 31, no. 11, pp. 909-915, 2006.
M
Yamamoto,
T
Kohno,
M
Murasawa,
H
Ono,
S
Ueda,
Y
Hayashi,
S
Ataka, and
K
Shiraki,
Lipofuscin autofluorescence in a case of crystalline retinopathy., Japanese Journal of Clinical Ophthalmology , vol. 60, no. 6, pp. 1039-1043, 2006.
Lipofuscin autofluorescence in a case of crystalline retinopathy., Japanese Journal of Clinical Ophthalmology , vol. 60, no. 6, pp. 1039-1043, 2006.
J.
Kandulla, and
H.
Elsner,
Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation, Journal of Biomedical Optics , vol. 11, no. 4, pp. 041111, 2006.
Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation, Journal of Biomedical Optics , vol. 11, no. 4, pp. 041111, 2006.
DOI: | Artn 041111 Doi 10.1117/1.2236301 |
File: | WOS:000241162000016 |
Bibtex: | @article{Kandulla2006, author = {Kandulla, J. and Elsner, H. and Birngruber, R. and Brinkmann, R.}, title = {Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation}, journal = {Journal of Biomedical Optics}, volume = {11}, number = {4}, note = {093IM Times Cited:30 Cited References Count:40}, abstract = {The therapeutic effect of most retinal laser treatments is initiated by a transient temperature increase. Although crucial to the effectiveness of the treatment, the temperature course is not exactly known due to individually different tissue properties. We develop an optoacoustic method to determine the retinal temperature increase in real time during continuous-wave (cw) laser irradiation, and perform temperature calculations to interpret the results exemplary for transpupillary thermotherapy (TTT). Porcine globes ex vivo and rabbit eyes in vivo are irradiated with a diode laser (lambda=810 nm, P <= 3 W, phi = 2 mm) for 60 s. Simultaneously, pulses from a N-2-laser pumped dye laser (lambda= 500 nm, tau= 3.5 ns, E approximate to 5 mu J) are applied on the retina. Following its absorption, an ultrasonic pressure wave is emitted, which is detected by a transducer embedded in a contact lens. Using the previously measured temperature-dependent Gruneisen coefficient of chorioretinal tissue, a temperature raise in porcine eyes of 5.8 degrees C/ (W/cm(2)) after 60 s is observed and confirmed by simultaneous measurements with an inserted thermocouple. In a rabbit, we find 1.4 degrees C/(W/cm(2)) with, and 2.2 degrees C/(W/cm(2)) without perfusion at the same location. Coagulation of the rabbit's retina occurs at Delta T = 21 degrees C after 40 s. In conclusion, this optoacoustic method seems feasible for an in vivo real-time determination of temperature, opening the possibility for feedback control retinal laser treatments. (c) 2006 Society of Photo-Optical Instrumentation Engineers.}, keywords = {temperature optoacoustics transpupillary thermotherapy ultrasonic transducer laser heat diffusion calculations retinal laser treatment subfoveal choroidal neovascularization transpupillary thermotherapy macular degeneration ocular media blood flow eye fundus light photocoagulation transmission}, ISSN = {1083-3668}, DOI = {Artn 041111 Doi 10.1117/1.2236301}, url = {<Go to ISI>://WOS:000241162000016}, year = {2006}, type = {Journal Article} } |
J. Roider,
Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results, Bull Soc Belge Ophtalmol , no. 302, pp. 51-69, 2006.
Selective retina therapy (SRT): a review on methods, techniques, preclinical and first clinical results, Bull Soc Belge Ophtalmol , no. 302, pp. 51-69, 2006.
H.
Hoerauf,
A.
Brix,
J.
Winkler,
G.
Droege,
H.
Laqua, and
A.
Vogel,
Photoablation of inner limiting membrane and inner retinal layers using the erbium : YAG-laser: An in vitro study, Lasers in Surgery and Medicine , vol. 38, no. 1, pp. 52-61, 2006.
Photoablation of inner limiting membrane and inner retinal layers using the erbium : YAG-laser: An in vitro study, Lasers in Surgery and Medicine , vol. 38, no. 1, pp. 52-61, 2006.
DOI: | Doi 10.1002/Lsm.20269 |
File: | WOS:000235149600007 |
Bibtex: | @article{Hoerauf2006, author = {Hoerauf, H. and Brix, A. and Winkler, J. and Droege, G. and Winter, C. and Birngruber, R. and Laqua, H. and Vogel, A.}, title = {Photoablation of inner limiting membrane and inner retinal layers using the erbium : YAG-laser: An in vitro study}, journal = {Lasers in Surgery and Medicine}, volume = {38}, number = {1}, pages = {52-61}, note = {009YN Times Cited:4 Cited References Count:51}, abstract = {Background and Objectives: To explore the potential of Er:YAG-laser irradiation for precise and tractionless retinal tissue and inner limiting membrane ablation. Materials and Methods: We used free-running Er:YAG-laser irradiation (lambda = 2.94 mu m) transmitted either through a 10 em long low-OH-quartz fiber or a 2 m long sapphire fiber that produced a more homogenous light distribution at the fiber tip. Retinal ablation in porcine retinal explants was performed under air or perfluorodecaline (PFD). Ablation depth was evaluated by optical coherence tomography (OCT) and from histologic sections. Results: A radiant exposure of 5.0 J/cm(2) delivered through a low-OH-quartz fiber and PFD caused a complete transsection of the neurosensory retina. Radiant exposures between 3.5 and 2.0 J/cm(2) resulted in marked variations of ablation depth and adjacent thermal damage. By contrast, laser pulses of 4.0 and 3.0 J/cm(2) transmitted through the sapphire fiber produced more homogenous defect patterns and less thermal damage. Close to the ablation threshold, with 1.0-2.0 J/cm(2), ablation was limited to a 10-20 mu m thin layer of the neural retina. Conclusions: We achieved in vitro ablation of inner retinal layers, but could not produce selective and reproducible ILM removal.}, keywords = {macular surgery optical coherence tomography perfluorocarbon liquid retina retinal explant optical coherence tomography macular hole surgery experimental vitreous membranes er-yag vitreoretinal surgery clinical-experience indocyanine green excimer-laser pig eyes ablation}, ISSN = {0196-8092}, DOI = {Doi 10.1002/Lsm.20269}, url = {<Go to ISI>://WOS:000235149600007}, year = {2006}, type = {Journal Article} } |
C.
Klatt,
H.
Elsner,
E.
Porksen,
A.
Bunse, and
J.
Roider,
Selektive Retina-Therapie bei Retinopathia centralis serosa mit Pigmentepithelabhebung, Ophthalmologe , vol. 103, no. 10, pp. 850-855, 2006.
Selektive Retina-Therapie bei Retinopathia centralis serosa mit Pigmentepithelabhebung, Ophthalmologe , vol. 103, no. 10, pp. 850-855, 2006.
H
Elsner,
E
Pörksen,
C
Klatt,
A
Bunse,
H
Laqua, and
J
Roider,
Selective Retina Therapy (SRT) in patients with central serous chorioretinopathy (CSC), Graefes Arch Ophthalmol, in print. , vol. on-line: DOI 10.1007/s00417-006-0368-5, 2006.
Selective Retina Therapy (SRT) in patients with central serous chorioretinopathy (CSC), Graefes Arch Ophthalmol, in print. , vol. on-line: DOI 10.1007/s00417-006-0368-5, 2006.
H.
Elsner,
C.
Klatt,
S.
Liew,
E.
Porksen,
A.
Bunse,
M.
Rudolf,
R.
Hamilton,
H.
Laqua, and
J.
Roider,
Selektive Retina Therapiey (SRT) bei Patienten mit diabetischer Makulopathie, Ophthalmologe , vol. 103, no. 10, pp. 856-860, 2006.
Selektive Retina Therapiey (SRT) bei Patienten mit diabetischer Makulopathie, Ophthalmologe , vol. 103, no. 10, pp. 856-860, 2006.
File: | query.fcgi |
Bibtex: | @article{Elsner2006, author = {Elsner, H. and Klatt, C. and Liew, S. H. and Porksen, E. and Bunse, A. and Rudolf, M. and Brinkmann, R. and Hamilton, R. P. and Birngruber, R. and Laqua, H. and Roider, J.}, title = {Selektive Retina Therapiey (SRT) bei Patienten mit diabetischer Makulopathie}, journal = {Ophthalmologe}, volume = {103}, number = {10}, pages = {856-860}, note = {0941-293X (Print) Journal article}, abstract = {Selective Retina Therapy (SRT) is a new laser treatment that selectively targets the retinal pigmen epithelium (RPE). In this study, we treated 39 patients presenting with nonischemic, focal and focal-diffuse diabetic maculopathy with SRT. In the main. the results indicate that SRT had stabilizing effects on visual acuity, angiographic leakage, lipid exudation, and foveal retinal thickness. SRT is safe and is especially useful for treating pathologies that are located close to the fovea, which cannot be treated with conventional argon laser photocoagulation.}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16937095}, year = {2006}, type = {Journal Article} } |
R. Brinkmann,
Selektive Retina-Therapie (SRT), Zeitschrift für Medizinische Physik , vol. 17, no. 1, pp. 6-22, 2006.
Selektive Retina-Therapie (SRT), Zeitschrift für Medizinische Physik , vol. 17, no. 1, pp. 6-22, 2006.
A. Vogel,
Stress wave emission and cavitation bubble dynamics by nanosecond optical breakdown in a tissue phantom., J Fluid Mech , vol. 558, pp. 281-308, 2006.
Stress wave emission and cavitation bubble dynamics by nanosecond optical breakdown in a tissue phantom., J Fluid Mech , vol. 558, pp. 281-308, 2006.
C.
Ahlers,
S.
Michels,
A.
Beckendorf, and
U.
Schmidt-Erfurth,
Three-dimensional imaging of pigment epithelial detachment in age-related macular degeneration using optical coherence tomography, retinal thickness analysis and topographic angiography, Graefes Archive for Clinical and Experimental Ophthalmology , vol. 244, no. 10, pp. 1233-1239, 2006.
Three-dimensional imaging of pigment epithelial detachment in age-related macular degeneration using optical coherence tomography, retinal thickness analysis and topographic angiography, Graefes Archive for Clinical and Experimental Ophthalmology , vol. 244, no. 10, pp. 1233-1239, 2006.
DOI: | DOI 10.1007/s00417-006-0418-z |
File: | WOS:000240729400003 |
Bibtex: | @article{Ahlers2006, author = {Ahlers, C. and Michels, S. and Beckendorf, A. and Birngruber, R. and Schmidt-Erfurth, U.}, title = {Three-dimensional imaging of pigment epithelial detachment in age-related macular degeneration using optical coherence tomography, retinal thickness analysis and topographic angiography}, journal = {Graefes Archive for Clinical and Experimental Ophthalmology}, volume = {244}, number = {10}, pages = {1233-1239}, note = {087FX Times Cited:16 Cited References Count:19}, abstract = {Introduction: New diagnostic tools such as the retinal thickness analyzer (RTA), optical coherence tomography (OCT), and topographic angiography (TAG) were introduced into clinical ophthalmology during the last years giving the examiner new insights into anatomical and functional aspects of macular disease. In this study, advantages and disadvantages of the new imaging methods have been evaluated in patients with serous (sPED) and fibrovascular pigment epithelial detachments (fPED) secondary to age-related macular degeneration (AMD). Methods: TAG, using fluorescein angiography (FA), provides a three-dimensional profile of the fluorescein pattern based on the analysis of a set of 32 confocal images over a depth of 4 mm. RTA and OCT provide cross-sectional images of the neurosensory retina and the retinal pigment epithelium-choriocapillary complex as well as retinal thickness data encoded in a false color map. We compared and evaluated these modalities in 15 patients with fPED and 15 patients with sPED secondary to AMD. Results: In patients with classic fPED, TAG detected neovascular structures and delineated their configuration. In sPEDs, pooling of extravascular fluid was detected in a dome-shaped configuration. OCT provided detailed information on the neurosensory retina's structures but failed to detect the neovascular membrane in fPED. Mapping the retinal thickness, RTA and OCT both failed to detect the PED and showed typical algorithm error-based patterns. Conclusions: TAG OCT and RTA are useful imaging modalities in the evaluation of AMD cases. TAG visualizes the vascular configuration, dynamic perfusion, and leakage changes. OCT and RTA are able to complementarily document intra-, subretinal, and sub-RPE fluid accumulation secondary to CNV. However, OCT seems to be more efficient in imaging AMD-related pathologies than RTA, as this modality is often compromised by intra- or subretinal structural abnormalities. Nevertheless, all modalities may provide further valuable insight into AMD pathogenesis, enhance diagnostic quality, and improve the assessment of therapeutic effects.}, keywords = {choroidal neovascularization pigment epithelial detachment (ped) topographic angiography retinal thickness analyzer age-related macular degeneration (amd) optical coherence tomography imaging choroidal neovascularization verteporfin therapy disease repeatability eyes oct tap}, ISSN = {0721-832X}, DOI = {DOI 10.1007/s00417-006-0418-z}, url = {<Go to ISI>://WOS:000240729400003}, year = {2006}, type = {Journal Article} } |
C.
Klatt,
H.
Elsner,
E.
Porksen,
A.
Bunse, and
J.
Roider,
Selective retina therapy in central serous chorioretinopathy with detachment of the pigmentary epithelium, Ophthalmologe , vol. 103, no. 10, pp. 850-5, 2006.
Selective retina therapy in central serous chorioretinopathy with detachment of the pigmentary epithelium, Ophthalmologe , vol. 103, no. 10, pp. 850-5, 2006.
File: | query.fcgi |
Bibtex: | @article{Klatt2006, author = {Klatt, C. and Elsner, H. and Porksen, E. and Brinkmann, R. and Bunse, A. and Birngruber, R. and Roider, J.}, title = {Selective retina therapy in central serous chorioretinopathy with detachment of the pigmentary epithelium}, journal = {Ophthalmologe}, volume = {103}, number = {10}, pages = {850-5}, note = {0941-293X (Print) Case Reports English Abstract Journal Article}, abstract = {BACKGROUND: Selective Retina Therapy (SRT) is a new and innovative laser treatment modality that selectively treats the retinal pigmentary epithelium while sparing the photoreceptors. This therapeutic concept appears to be particularly suitable for treating patients with acute or chronic central serous chorioretinopathy (CSC). We present preliminary results obtained in five patients who had CSC associated with pigmentary epithelium detachment (PED) and serous subretinal fluid (SRF) and who were treated with SRT. METHODS: This case series was made up of five male patients (mean age 47 years) with chronic CSC and SRF resulting from PED. Examinations performed before and at 1 month and 3 months after the treatment were: BCVA, FLA, OCT (Zeiss OCT III). For SRT, confluent treatment of the PED (area of leakage) was carried out using a pulsed frequency-doubled, Q-switched Nd-YLF prototype laser (lambda=527 nm, t= 1.7 s, 100 Hz, energy = 150-250 J). RESULTS: Best corrected visual acuity at baseline was 0.53, while after 4 weeks it was 0.56 and after 12 weeks, 0.5. At baseline leakage was seen at the PED on fluorescein angiography in all patients. After 4 weeks leakage activity was no longer noted on angiography in 4 of 5 patients. OCT at baseline showed SRF at the edge of the PED in all patients, but in 4 of the 5 patients this was no longer detectable after 4 weeks. CONCLUSION: SRT is a safe and effective treatment for patients with CSC in which PED has caused SRF. Not a single case of rip syndrome was observed in this study, even though the PED was treated confluently. Since SRT spares the photoreceptors it is particularly suitable for the treatment of CSC, especially when the origin of leakage is located close to the fovea. The results indicate that SRT leads to reconstruction of the outer blood-retina barrier.}, keywords = {Adult Chorioretinitis/complications/*surgery Humans Laser Surgery/*methods Lasers/*therapeutic use Male Middle Aged Ophthalmologic Surgical Procedures/*methods Preoperative Care/methods Retinal Detachment/etiology/*surgery Treatment Outcome}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16937094}, year = {2006}, type = {Journal Article} } |
2005
R.
Huber,
M.
Wojtkowski,
J.
Fujimoto,
J.
Jiang, and
A.
Cable,
Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm, Opt. Express , vol. 13, no. 26, pp. 10523-10538, Dec. 2005. Optica Publishing Group.
Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm, Opt. Express , vol. 13, no. 26, pp. 10523-10538, Dec. 2005. Optica Publishing Group.
DOI: | 10.1364/OPEX.13.010523 |
Bibtex: | @article{Huber:05, author = {R. Huber and M. Wojtkowski and J. G. Fujimoto and J. Y. Jiang and A. E. Cable}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; High speed imaging; Image fusion; Laser sources; Semiconductor lasers; Swept lasers; Three dimensional imaging}, number = {26}, pages = {10523--10538}, publisher = {Optica Publishing Group}, title = {Three-dimensional and C-mode OCT imaging with a compact, frequency swept laser source at 1300 nm}, volume = {13}, month = {Dec}, year = {2005}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-13-26-10523}, doi = {10.1364/OPEX.13.010523}, abstract = {We demonstrate high resolution, three-dimensional OCT imaging with a high speed, frequency swept 1300 nm laser source. A new external cavity semiconductor laser design, optimized for application to swept source OCT, is discussed. The design of the laser enables adjustment of an internal spectral filter to change the filter bandwidth and provides a robust bulk optics design. The laser generates ~30 mW instantaneous peak power at an effective 16 kHz sweep rate with a tuning range of ~133 nm full width. In frequency domain reflectometry and OCT applications, 109 dB sensitivity and ~10 $\mu$m axial resolution in tissue can be achieved with the swept laser. The high imaging speeds enable three-dimensional OCT imaging, including zone focusing or C-mode imaging and image fusion to acquire large depth of field data sets with high resolution. In addition, three-dimensional OCT data provides coherence gated en face images similar to optical coherence microscopy (OCM) and also enables the generation of images similar to confocal microscopy by summing signals in the axial direction. High speed, three-dimensional OCT imaging can provide comprehensive data which combines the advantages of optical coherence tomography and microscopy in a single system.}, } |
R.
Huber,
K.
Taira,
M.
Wojtkowski, and
J.
Fujimoto,
Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates, in Optical Coherence Tomography and Coherence Techniques II , Wolfgang Drexler, Eds. SPIE, Oct.2005. pp. 58611B.
Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates, in Optical Coherence Tomography and Coherence Techniques II , Wolfgang Drexler, Eds. SPIE, Oct.2005. pp. 58611B.
DOI: | 10.1117/12.641732 |
Bibtex: | @inproceedings{10.1117/12.641732, author = {R. Huber and K. Taira and M. Wojtkowski and J. G. Fujimoto}, title = {{Fourier domain mode locked lasers for OCT imaging at up to 290 kHz sweep rates}}, volume = {5861}, booktitle = {Optical Coherence Tomography and Coherence Techniques II}, editor = {Wolfgang Drexler}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {58611B}, abstract = {A high speed, tunable laser using Fourier Domain Mode Locking is demonstrated for OCT imaging. Record sweep speeds up to 290 kHz, 3 cm coherence length and 145 nm range at 1300 nm are achieved.}, keywords = {Fourier domain mode locking, swept source, swept laser, tunable laser, wavelength agile laser, optical coherence tomography, spectral OCT, Fourier domain}, year = {2005}, doi = {10.1117/12.641732}, URL = {https://doi.org/10.1117/12.641732} } |
R.
Huber,
K.
Taira, and
J.
Fujimoto,
Fourier Domain Mode Locking: Overcoming limitations of frequency swept light sources and pulsed lasers, in Conference on Lasers and Electro-Optics Europe/ European Quantum Electronics Conference (CLEO/Europe - EQEC 2005) , 052005. pp. CP3-5-THU.
Fourier Domain Mode Locking: Overcoming limitations of frequency swept light sources and pulsed lasers, in Conference on Lasers and Electro-Optics Europe/ European Quantum Electronics Conference (CLEO/Europe - EQEC 2005) , 052005. pp. CP3-5-THU.
R.
Huber,
K.
Taira,
T.
Ko,
M.
Wojtkowski,
V.
Srinivasan,
J.
Fujimoto, and
K.
Hsu,
High-Speed, Amplified, Frequency Swept Laser at 20 kHz Sweep Rates for OCT Imaging - Technical Digest (CD), in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies , Optica Publishing Group, 052005. pp. JThE33.
High-Speed, Amplified, Frequency Swept Laser at 20 kHz Sweep Rates for OCT Imaging - Technical Digest (CD), in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies , Optica Publishing Group, 052005. pp. JThE33.
DOI: | 10.1109/QELS.2005.1549239 |
Bibtex: | @inproceedings{Huber:05, author = {R. Huber and K. Taira and T. H. Ko and M. Wojtkowski and V. Srinivasan and J. G. Fujimoto and K. Hsu}, booktitle = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies}, journal = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies}, keywords = {Imaging systems; Optical coherence tomography; Lasers and laser optics; Lasers, tunable; Laser amplifiers; Laser sources; Light sources; Optical coherence tomography; Point spread function; Ring lasers}, pages = {JThE33}, publisher = {Optica Publishing Group}, title = {High-speed, amplified, frequency swept laser at 20 kHz sweep rates for OCT imaging}, year = {2005}, url = {https://opg.optica.org/abstract.cfm?URI=QELS-2005-JThE33}, abstract = {We demonstrate a high-speed, frequency swept, 1300 nm laser for Fourier domain OCT. The laser generates ~45 mW instantaneous power with 20 kHz sweep rates and achieves 108 dB sensitivity and 12.7 um resolution.}, } |
V.
Sharma,
A.
Kowalczyk,
R.
Huber,
J.
Fujimoto, and
K.
Minoshima,
Three Dimensional Waveguide Splitters Fabricated in Glass Using a Femtosecond Laser Oscillator - Technical Digest (CD), in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies , Optica Publishing Group, 052005. pp. CThCC4.
Three Dimensional Waveguide Splitters Fabricated in Glass Using a Femtosecond Laser Oscillator - Technical Digest (CD), in Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies , Optica Publishing Group, 052005. pp. CThCC4.
DOI: | 10.1109/CLEO.2005.202363 |
Bibtex: | @inproceedings{Sharma:05, author = {V. Sharma and A. M. Kowalevicz and R. Huber and J. G. Fujimoto and K. Minoshima}, booktitle = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies}, journal = {Conference on Lasers and Electro-Optics/Quantum Electronics and Laser Science and Photonic Applications Systems Technologies}, keywords = {Optical design and fabrication; Microstructure fabrication; Ultrafast optics; Ultrafast processes in condensed matter, including semiconductors; Femtosecond lasers; Femtosecond pulses; Free electron lasers; High numerical aperture optics; Three dimensional fabrication; Ti:sapphire lasers}, pages = {CThCC4}, publisher = {Optica Publishing Group}, title = {Three dimensional waveguide splitters fabricated in glass using a femtosecond laser oscillator}, year = {2005}, url = {https://opg.optica.org/abstract.cfm?URI=CLEO-2005-CThCC4}, abstract = {Three-dimensional optical waveguide devices are fabricated in glass using femtosecond pulses from an extended cavity Ti:sapphire laser oscillator. We demonstrate increased device densities by fabricating highly symmetric 1:N waveguide splitters in three dimensions.}, } |
R.
Huber,
M.
Wojtkowski,
K.
Taira,
J.
Fujimoto, and
K.
Hsu,
Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles, Opt. Express , vol. 13, no. 9, pp. 3513-3528, 05 2005. Optica Publishing Group.
Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles, Opt. Express , vol. 13, no. 9, pp. 3513-3528, 05 2005. Optica Publishing Group.
DOI: | 10.1364/OPEX.13.003513 |
Bibtex: | @article{Huber:05, author = {R. Huber and M. Wojtkowski and K. Taira and J. G. Fujimoto and K. Hsu}, journal = {Opt. Express}, keywords = {Optical coherence tomography; Lasers, tunable; Fiber lasers; Fiber optic amplifiers; Fiber optic components; Laser sources; Light sources; Tunable diode lasers}, number = {9}, pages = {3513--3528}, publisher = {Optica Publishing Group}, title = {Amplified, frequency swept lasers for frequency domain reflectometry and OCT imaging: design and scaling principles}, volume = {13}, month = {May}, year = {2005}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-13-9-3513}, doi = {10.1364/OPEX.13.003513}, abstract = {We demonstrate a high-speed, frequency swept, 1300 nm laser source for frequency domain reflectometry and OCT with Fourier domain/swept-source detection. The laser uses a fiber coupled, semiconductor amplifier and a tunable fiber Fabry-Perot filter. We present scaling principles which predict the maximum frequency sweep speed and trade offs in output power, noise and instantaneous linewidth performance. The use of an amplification stage for increasing output power and for spectral shaping is discussed in detail. The laser generates ~45 mW instantaneous peak power at 20 kHz sweep rates with a tuning range of ~120 nm full width. In frequency domain reflectometry and OCT applications the frequency swept laser achieves 108 dB sensitivity and ~10 {\textmu}m axial resolution in tissue. We also present a fast algorithm for real time calibration of the fringe signal to equally spaced sampling in frequency for high speed OCT image preview.}, } |
R.
Huber,
K.
Taira,
M.
Wojtkowski,
T.
Ko,
J.
Fujimoto, and
K.
Hsu,
Figh-speed frequency swept light source for Fourier domain OCT at 20 kHz A-scan rate, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX , Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 042005. pp. 96-100.
Figh-speed frequency swept light source for Fourier domain OCT at 20 kHz A-scan rate, in Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX , Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 042005. pp. 96-100.
DOI: | 10.1117/12.592552 |
Bibtex: | @inproceedings{10.1117/12.592552, author = {Robert Huber and Kenji Taira and Maciej Wojtkowski and Tony Hong-Tyng Ko and James G. Fujimoto and Kevin Hsu}, title = {{High-speed-frequency swept light source for Fourier domain OCT at 20-kHz A-scan rate}}, volume = {5690}, booktitle = {Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine IX}, editor = {Valery V. Tuchin and Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {96 -- 100}, abstract = {We demonstrate a high-speed tunable, continuous wave laser source for Fourier domain OCT. The laser source is based on a fiber coupled, semiconductor optical amplifier and a tunable ultrahigh finesse, fiber Fabry Perot filter for frequency tuning. The light source provides frequency scan rates of up to 20,000 sweeps per second over a wavelength range of >70 nm FWHM at 1330 nm, yielding an axial resolution of ~14 μm in air. The linewidth is narrow and corresponds to a coherence length of several mm, enabling OCT imaging over a large axial range.}, keywords = {swept source, Fourier Domain, OCT, tunable laser, Spectral Domain, frequency domain imaging, OFDI, sweep}, year = {2005}, doi = {10.1117/12.592552}, URL = {https://doi.org/10.1117/12.592552} } |
R.
Huber,
T.
Köhler,
M.
Lenz,
E.
Bamberg,
R.
Kalmbach,
M.
Engelhard, and
J.
Wachtveitl,
pH-dependent photoisomerization of retinal in proteorhodopsin., Biochemistry , vol. 44, no. 6, pp. 1800-1806, 01 2005.
pH-dependent photoisomerization of retinal in proteorhodopsin., Biochemistry , vol. 44, no. 6, pp. 1800-1806, 01 2005.
DOI: | 10.1021/bi048318h |
Bibtex: | @article{doi:10.1021/bi048318h, author = {Huber, Robert and Köhler, Thomas and Lenz, Martin O. and Bamberg, Ernst and Kalmbach, Rolf and Engelhard, Martin and Wachtveitl, Josef}, title = {pH-Dependent Photoisomerization of Retinal in Proteorhodopsin}, journal = {Biochemistry}, volume = {44}, number = {6}, pages = {1800-1806}, year = {2005}, doi = {10.1021/bi048318h}, note ={PMID: 15697205}, URL = {https://doi.org/10.1021/bi048318h}, eprint = {https://doi.org/10.1021/bi048318h}, abstract = {The early steps in the photocycle of the bacterial proton pump proteorhodopsin (PR) were analyzed by ultrafast pump/probe spectroscopy to compare the rate of retinal isomerization at alkaline and acidic pH values. At pH 9, the functionally important primary proton acceptor (Asp97, pKa = 7.7) is negatively charged; consequently, a reaction cycle analogous to the archaeal bacteriorhodopsin (BR) is observed. The excited electronic state of PR displays a pronounced biphasic decay with time constants of 400 fs and 8 ps. At pH 6 where Asp97 is protonated a similar biphasic decay is observed, although it is significantly slower (700 fs and 15 ps). The results indicate, in agreement to similar findings in other retinal proteins, that also in PR the charge distribution within the chromophore binding pocket is a major determinant for the rate and the efficiency of the primary reaction. } } |
A
Vogel,
B.
Lorenz,
B.
Sägmüller, and
K.
Schütze,
Catapulting of microdissected histologic specimens with focused and defocused laser pulses, Optical Society of America , 2005.
Catapulting of microdissected histologic specimens with focused and defocused laser pulses, Optical Society of America , 2005.
C Brinkmann,
Non-invasive real-time retinal temperature determination during TTT, Invest Ophthal & VisScie , 2005.
Non-invasive real-time retinal temperature determination during TTT, Invest Ophthal & VisScie , 2005.
R.
Rahmanzadeh,
K.
Muller,
E.
Fischer,
D.
Bartels, and
T.
Borsch,
The Linderniaceae and Gratiolaceae are further lineages distinct from the Scrophulariaceae (Lamiales), vol. 7, no. 1, pp. 67-78, 2005.
The Linderniaceae and Gratiolaceae are further lineages distinct from the Scrophulariaceae (Lamiales), vol. 7, no. 1, pp. 67-78, 2005.
DOI: | 10.1055/s-2004-830444 |
ISBN: | 1435-8603 (Print) 1435-8603 (Linking) |
Bibtex: | @misc{Rahmanzadeh, author = {Rahmanzadeh, R. and Muller, K. and Fischer, E. and Bartels, D. and Borsch, T.}, title = {The Linderniaceae and Gratiolaceae are further lineages distinct from the Scrophulariaceae (Lamiales)}, volume = {7}, number = {1}, pages = {67-78}, month = {Jan}, note = {Rahmanzadeh, R Muller, K Fischer, E Bartels, D Borsch, T Research Support, Non-U.S. Gov't Germany Plant Biol (Stuttg). 2005 Jan;7(1):67-78.}, abstract = {The Lamiales are one of the largest orders of angiosperms, with about 22,000 species. The Scrophulariaceae, as one of their most important families, has recently been shown to be polyphyletic. As a consequence, this family was re-classified and several groups of former scrophulariaceous genera now belong to different families, such as the Calceolariaceae, Plantaginaceae, or Phrymaceae. In the present study, relationships of the genera Craterostigma, Lindernia and its allies, hitherto classified within the Scrophulariaceae, were analyzed. Sequences of the chloroplast trnK intron and the matK gene (approximately 2.5 kb) were generated for representatives of all major lineages of the Lamiales and the former Scrophulariaceae. Bayesian and parsimony analyses revealed two isolated lineages, one of which consists of Lindernia and its allies, the other of Gratiola and allies. Gratiola was previously assumed to be related to Lindernia and was therefore included here. It is proposed to treat the two clades as separate families, Linderniaceae and Gratiolaceae. For the Linderniaceae, several morphological synapomorphies exist in addition to molecular data, such as conspicuous club-shaped stamen appendages.}, keywords = {Bayes Theorem Genes, Plant Introns Phenotype Phylogeny Scrophulariaceae/anatomy & histology/ classification/genetics Species Specificity}, ISBN = {1435-8603 (Print) 1435-8603 (Linking)}, year = {2005} } |
C.
Framme,
G.
Schuele,
J.
Roider, and
F.
Holz,
Temperature dependence of A2-E fluorescence in vitro and detection of fundus autofluorescence during selective RPE laser treatment (SRT), Investigative Ophthalmology & Visual Science , vol. 46, 2005.
Temperature dependence of A2-E fluorescence in vitro and detection of fundus autofluorescence during selective RPE laser treatment (SRT), Investigative Ophthalmology & Visual Science , vol. 46, 2005.
H.
Elsner,
S.
Liew,
C.
Klatt,
P.
Hamilton,
J.
Marshall,
E.
Porksen,
H.
Laqua, and
J.
Roider,
Selective-retina-therapy (SRT) multicenter clinical trial: 6 month results in patients with diabetic maculopathy, Investigative Ophthalmology & Visual Science , vol. 46, 2005.
Selective-retina-therapy (SRT) multicenter clinical trial: 6 month results in patients with diabetic maculopathy, Investigative Ophthalmology & Visual Science , vol. 46, 2005.
C.
Alt,
C.
Framme,
S.
Schnell,
H.
Lee, and
C.
Lin,
Selective targeting of the retinal pigment epithelium using an acousto-optic laser scanner, J Biomed Opt , vol. 10, no. 6, pp. 64014, 2005.
Selective targeting of the retinal pigment epithelium using an acousto-optic laser scanner, J Biomed Opt , vol. 10, no. 6, pp. 64014, 2005.
E.
Poerksen,
H.
Elsner,
G.
Schuele,
P.
Hamilton,
H.
Laqua, and
J.
Roider,
Selective retina treatment (SRT): Clinical investigation of an optoacoustic on-line dosimetry control, Investigative Ophthalmology & Visual Science , vol. 46, 2005.
Selective retina treatment (SRT): Clinical investigation of an optoacoustic on-line dosimetry control, Investigative Ophthalmology & Visual Science , vol. 46, 2005.
G
Schüle, and
M
Rumohr,
RPE damage thresholds and mechanisms for laser exposure in the µs to ms time regimen, Inv Ophthalmol & Vis Sci , vol. 46, no. 2, pp. 714-719, 2005.
RPE damage thresholds and mechanisms for laser exposure in the µs to ms time regimen, Inv Ophthalmol & Vis Sci , vol. 46, no. 2, pp. 714-719, 2005.
S.
Nakakura,
K.
Shiraki,
T.
Yasunari,
Y.
Hayashi,
S.
Ataka, and
T.
Kohno,
Quantification and anatomic distribution of choroidal abnormalities in patients with type I neurofibromatosis, Graefes Arch Clin Exp Ophthalmol , vol. 243, no. 10, pp. 980-4, 2005.
Quantification and anatomic distribution of choroidal abnormalities in patients with type I neurofibromatosis, Graefes Arch Clin Exp Ophthalmol , vol. 243, no. 10, pp. 980-4, 2005.
F
Kasahara,
T
Yokoyama,
Y
Hayashi,
Y
Kato,
M
Yamaguchi, and
K
Shiraki,
Postoperative results of distance stereoacuity in intermittent exotropia, Japanese Review of Clinical Ophthalmology , vol. 99, no. 3, pp. 246-249, 2005.
Postoperative results of distance stereoacuity in intermittent exotropia, Japanese Review of Clinical Ophthalmology , vol. 99, no. 3, pp. 246-249, 2005.
K
Herrmann, and
D.
Pauleikhoff,
Photodynamische Therapie in der Praxis immer breiter eingesetzt., Beilage für "Der Ophthalmologe" , vol. 102, no. 6, 2005.
Photodynamische Therapie in der Praxis immer breiter eingesetzt., Beilage für "Der Ophthalmologe" , vol. 102, no. 6, 2005.
R Schuele,
Optoacoustic real-time dosimetry for selective retina treatment, J Biomed Opt , vol. 10, no. 6, pp. 064022, 2005.
Optoacoustic real-time dosimetry for selective retina treatment, J Biomed Opt , vol. 10, no. 6, pp. 064022, 2005.
DOI: | Artn 064022 Doi 10.1117/1.2136327 |
File: | WOS:000234859400024 |
Bibtex: | @article{Schuele2005, author = {Schuele, G; Elsner, H; Framme, C; Roider, J; Birngruber, R and Brinkmann, R}, title = {Optoacoustic real-time dosimetry for selective retina treatment}, journal = {J Biomed Opt}, note = {005XJ Times Cited:17 Cited References Count:37}, abstract = {The selective retina treatment ( SRT ) targets retinal diseases associated with disorders in the retinal pigment epithelium ( RPE ). Due to the ophthalmoscopic invisibility of the laser- induced RPE effects, we investigate a noninvasive optoacoustic real- time dosimetry system. In vitro porcine RPE is irradiated with a Nd: YLF laser ( 527 nm, 1.7- mu s pulse duration, 5 to 40 mu J, 30 pulses, 100- Hz repetition rate). Generated acoustic transients are measured with a piezoelectric transducer. During 27 patient treatments, the acoustic transients are measured with a transducer embedded in an ophthalmic contact lens. After treatment, RPE damage is visualized by fluorescein angiographic leakage. Below the RPE damage threshold, the optoacoustic transients show no pulse- to- pulse fluctuations within a laser pulse train. Above threshold, fluctuations of the individual transients among each other are observed. If optoacoustic pulse- to- pulse fluctuations are present, RPE leakage is observed in fluorescein angiography. In 96% of the irradiated areas, RPE leakage correlated with the optoacoustic defined threshold value. A noninvasive optoacoustic real- time dosimetry for SRT is developed and proved in vitro and during patient treatment. It detects the ophthalmoscopically invisible laser- induced damage of RPE cells and overcomes practical limitations of SRT for use in private practice. (C) 2005 Society of Photo- Optical Instrumentation Engineers.}, keywords = {selective retina treatment optoacoustic dosimetry real-time dosimetry laser retina randomized clinical-trial macular degeneration diabetic-retinopathy photocoagulation nanosecond eye temperature generation liquids regimen}, ISSN = {1083-3668}, DOI = {Artn 064022 Doi 10.1117/1.2136327}, url = {<Go to ISI>://WOS:000234859400024}, year = {2005} } |
G.
Schuele,
H.
Elsner,
C.
Framme, and
J.
Roider,
Optoacoustic real-time dosimetry for selective retina treatment, J Biomed Opt , vol. 10, no. 6, pp. 064022, 2005.
Optoacoustic real-time dosimetry for selective retina treatment, J Biomed Opt , vol. 10, no. 6, pp. 064022, 2005.
D.
Zimmermann,
D.
Bollmann,
I.
Rohde,
D.
Theisen-Kunde, and
R.
Brinkmann,
Compact, Q-switched Yb:YAG laser with a new longitudinal pumping concept, in CLEO/Europe. 2005 Conference on Lasers and Electro-Optics Europe, 2005. , 2005. pp. 78-.
Compact, Q-switched Yb:YAG laser with a new longitudinal pumping concept, in CLEO/Europe. 2005 Conference on Lasers and Electro-Optics Europe, 2005. , 2005. pp. 78-.
DOI: | 10.1109/CLEOE.2005.1567867 |
Bibtex: | @INPROCEEDINGS{1567867, author={Zimmermann, D. and Bollmann, D. and Rohde, I. and Theisen-Kunde, D. and Brinkmann, R.}, booktitle={CLEO/Europe. 2005 Conference on Lasers and Electro-Optics Europe, 2005.}, title={Compact, Q-switched Yb:YAG laser with a new longitudinal pumping concept}, year={2005}, volume={}, number={}, pages={78-}, doi={10.1109/CLEOE.2005.1567867}} |
C
Framme,
J
Roider,
H.
Sachs, and
V.
Gabel,
Noninvasive Imaging and Monitoring of Retinal Pigment Epithelium Patterns Using Fundus Autofluorescence - Review, Curr Med Imag Rev , vol. 1, pp. 89-103, 2005.
Noninvasive Imaging and Monitoring of Retinal Pigment Epithelium Patterns Using Fundus Autofluorescence - Review, Curr Med Imag Rev , vol. 1, pp. 89-103, 2005.
C.
Yao, and
E.
Endl,
New concepts in laser medicine: Towards a laser surgery with cellular precision, Medical laser application , vol. 20, no. 2, pp. 135-139, 2005.
New concepts in laser medicine: Towards a laser surgery with cellular precision, Medical laser application , vol. 20, no. 2, pp. 135-139, 2005.
C.
Ahlers,
S.
Michels,
H.
Elsner,
C.
Pruente, and
U.
Schmidt-Erfurth,
Topographic angiography and optical coherence tomography: A correlation of imaging characteristics, European Journal of Ophthalmology , vol. 15, no. 6, pp. 774-781, 2005.
Topographic angiography and optical coherence tomography: A correlation of imaging characteristics, European Journal of Ophthalmology , vol. 15, no. 6, pp. 774-781, 2005.
U.
Schmidt-Erfurth,
S.
Michels,
L.
Indorf, and
R.
Eggers,
Mechanism of photodynamic occlusion using liposomal Zn(II)-phtalocyanine, Current Eye Research , vol. 30, no. 7, pp. 601-612, 2005.
Mechanism of photodynamic occlusion using liposomal Zn(II)-phtalocyanine, Current Eye Research , vol. 30, no. 7, pp. 601-612, 2005.
DOI: | Doi 10.1080/02713680590968286 |
File: | WOS:000231078000012 |
Bibtex: | @article{Schmidt-Erfurth2005, author = {Schmidt-Erfurth, U. and Michels, S. and Indorf, L. and Eggers, R. and Birngruber, R.}, title = {Mechanism of photodynamic occlusion using liposomal Zn(II)-phtalocyanine}, journal = {Current Eye Research}, volume = {30}, number = {7}, pages = {601-612}, note = {953LO Times Cited:2 Cited References Count:30}, abstract = {Purpose: To evaluate the potential of liposomal Zinc(II)phthalocyanine (ZnPc) to selectively target subretinal vasculature. Methods: Photodynamic therapy (PDT) with liposomal Zinc(II)-phtalocyanine was used to induce choroidal occlusion in eyes of pigmented rabbits. Drug doses of 0.16, 0.24, 0.32, and 0.4 mg/kg body weight were administered. Photosensitization was performed at a wavelength of 671 nm and an irradiance of 100 mW/cm(2) applying fluences of 5, 10, 20, and 50 J/cm(2). Results: Using liposomal ZnPc, occlusion of choroidal vessels was achieved without damage to the overlying neurosensory retina. A tight dose correlation was found with a drug dose of 0.32 mg/kg and a light dose of 10 J/cm(2) inducing a selective thrombosis of the subretinal capillary layer. Histology revealed a selective intravascular alteration of the endothelial cells. Conclusions: PDT using liposomal ZnPc allows occlusion of subretinal vasculature with maintenance of neuroretina and RPE. The destructive effect on choroidal vascular endothelium is intensive.}, keywords = {choroidal vasculature liposomes photodynamic therapy zinc(ii)-phtalocyanine low-density-lipoprotein receptor-mediated uptake choroidal neovascularization macular degeneration endothelial-cells therapy verteporfin angiography model}, ISSN = {0271-3683}, DOI = {Doi 10.1080/02713680590968286}, url = {<Go to ISI>://WOS:000231078000012}, year = {2005}, type = {Journal Article} } |
I.
Apitz, and
A.
Vogel,
Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin, Applied Physics A: Materials Science & Processing , vol. 81, no. 2, pp. 329-338, 2005.
Material ejection in nanosecond Er:YAG laser ablation of water, liver, and skin, Applied Physics A: Materials Science & Processing , vol. 81, no. 2, pp. 329-338, 2005.