Proceedings

2017

  • Eibl, Matthias and Karpf, Sebastian and Hakert, Hubertus and Weng, Daniel and Huber, Robert: Two-photon-excited fluorescence (TPEF) and fluorescence lifetime imaging (FLIM) with sub-nanosecond pulses and a high analog bandwidth signal detection. in Proc. SPIE, no. 10069, pp. 100691F-6, 2017
    BibTeX Link
    @inproceedings{Eibl2017,
       author = {Eibl, Matthias and Karpf, Sebastian and Hakert, Hubertus and Weng, Daniel and Huber, Robert},
       title = {Two-photon-excited fluorescence (TPEF) and fluorescence lifetime imaging (FLIM) with sub-nanosecond pulses and a high analog bandwidth signal detection},
    booktitle = {Proc. SPIE },
       volume = {10069},
       pages = {100691F-6},
       doi= {10.1117/12.2250831},
      year={2017},
    keywords = {AG-Huber_NL},
       type = {Conference Proceedings}
    }
    
  • Hakert, H; Eibl, M; Karpf, S and Huber, R: Sparse-sampling with time-encoded (TICO) stimulated Raman scattering for fast image acquisition. in Proc. SPIE 10414, pp. 1041408-1041408-7, 2017
    BibTeX Link
    @inproceedings{Hakert2017,
       author = {Hakert, H; Eibl, M; Karpf, S and Huber, R},
       title = {Sparse-sampling with time-encoded (TICO) stimulated Raman scattering for fast image acquisition},
    booktitle = {Proc. SPIE} {10414},
    Year={2017},
       
       pages = {1041408-1041408-7},
       url = {http://dx.doi.org/10.1117/12.2287947},
    keywords = {AG-Huber_NL},
       type = {Conference Proceedings}
    }
    
  • Eibl, M; Karpf, S; Hakert, H; Weng, D; Pfeiffer, T; Kolb, J P and Huber, R: Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup. in Proc. SPIE 10414, pp. 1041403-1041403-7, 2017
    BibTeX Link
    @inproceedings{Eibl2017,
       author = {Eibl, M; Karpf, S; Hakert, H; Weng, D; Pfeiffer, T; Kolb, J P and Huber, R},
       title = {Single pulse two-photon fluorescence lifetime imaging (SP-FLIM) with MHz pixel rate and an all fiber based setup},
      booktitle = {Proc. SPIE} {10414},
      
      year = {2017},
    keywords = {AG-Huber_NL},
       pages = {1041403-1041403-7},
      
     url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10414/1/Single-pulse-two-photon-fluorescence-lifetime-imaging-SP-FLIM-with/10.1117/12.2286035.short?SSO=1},
       type = {Conference Proceedings}
    }
    
  • Wang, Tianshi and Pfeiffer, Tom and Wu, Min and Wieser, Wolfgang and Draxinger, Wolfgang and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs: Short pulse laser induced thermo-elastic deformation imaging. in Proc. SPIE, no. 10062, pp. 100620C-100620C-4, 2017
    BibTeX Link
    @inproceedings{Wang2017,
       author = {Wang, Tianshi and Pfeiffer, Tom and Wu, Min and Wieser, Wolfgang and Draxinger, Wolfgang and van der Steen, Antonius F. W. and Huber, Robert and van Soest, Gijs},
       title = {Short pulse laser induced thermo-elastic deformation imaging},
    booktitle = Proc. SPIE},
      volume = {10062},
      year = {2017},
       pages = {100620C-100620C-4},
      url = {http://dx.doi.org/10.1117/12.2251502},
    keywords = {AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
    
  • Bliedtner, K; Seifert, E; Brinkmann, R and Amelink A: Real Time Speckle Monitoring to Control Retinal Photocoagulation. in Proc. SPIE 10413, pp. 1041308-1-7, 2017
    BibTeX Link
    @inproceedings{Bliedtner2017,
       author = {Bliedtner, K; Seifert, E; Brinkmann, R and  Amelink A},
       title = {Real Time Speckle Monitoring to Control Retinal Photocoagulation},
       booktitle = {Proc. SPIE} {10413},
       
       pages = {1041308-1-7},
      
    url = { https://doi.org/10.1117/12.2287815},
    Year = { 2017}
  • Eibl, Matthias and Karpf, Sebastian and Hakert, Hubertus and Weng, Daniel and Blömker, Torben and Huber, Robert: Pulse-to-pulse wavelength switching of diode based fiber laser for multi-color multi-photon imaging. in Proc. SPIE, no. 10083, pp. 100831C-6, 2017
    BibTeX Link
    @inproceedings{Eibl2017,
       author = {Eibl, Matthias and Karpf, Sebastian and Hakert, Hubertus and Weng, Daniel and Blömker, Torben and Huber, Robert},
       title = {Pulse-to-pulse wavelength switching of diode based fiber laser for multi-color multi-photon imaging},
    booktitle = {Proc. SPIE },
       volume = {10083},
       pages = {100831C-6},
       year= {2017},
       doi= {10.1117/12.2251965},
    keywords = {AG-Huber_NL},
       type = {Conference Proceedings}
    }
    
  • Pfeiffer, T; Draxinger, W; Grill, C and Huber, R: Long-range live 3D-OCT at different spectral zoom levels. in Proc. SPIE 10416, pp. 104160L1-4, 2017
    BibTeX Link
    @inproceedings{Pfeiffer2017,
       author = {Pfeiffer, T; Draxinger, W; Grill, C and Huber, R},
       title = {Long-range live 3D-OCT at different spectral zoom levels},
       booktitle = {Proc. SPIE} {10416},
      url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10416/1/Long-range-live-3D-OCT-at-different-spectral-zoom-levels/10.1117/12.2287484.short?SSO=1},
       pages = {104160L1-4},
       year = {2017},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Laves, Max-Heinrich and Schoob, Andreas and Kahrs, Lüder A. and Pfeiffer, Tom and Huber, Robert and Ortmaier, Tobias: Feature tracking for automated volume of interest stabilization on 4D-OCT images. in Proc. SPIE, no. 10135, pp. 101350W-101350W-7, 2017
    BibTeX Link
    @inproceedings{Laves2017,
       author = {Laves, Max-Heinrich and Schoob, Andreas and Kahrs, Lüder A. and Pfeiffer, Tom and Huber, Robert and Ortmaier, Tobias},
       title = {Feature tracking for automated volume of interest stabilization on 4D-OCT images},
     booktitle = {Proc. SPIE},
       volume = {10135},
       pages = {101350W-101350W-7},
      year = {2017},
       url = {http://dx.doi.org/10.1117/12.2255090},
    keywords = {AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Pfeiffer, Tom and Draxinger, Wolfgang and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Huber, Robert: Analysis of FDML lasers with meter range coherence. in Proc. SPIE, no. 10053, pp. 100531T-100531T-6, 2017
    BibTeX Link
    @inproceedings{Pfeiffer2017,
       author = {Pfeiffer, Tom and Draxinger, Wolfgang and Wieser, Wolfgang and Klein, Thomas and Petermann, Markus and Huber, Robert},
       title = {Analysis of FDML lasers with meter range coherence},
       booktitle = {Proc. SPIE},
       volume = {10053},
       pages = {100531T-100531T-6},
        url = {http://dx.doi.org/10.1117/12.2254792},
    
      year = {2017},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Kolb, J P; Klee, J; Pfeiffer, Tand Huber, R: 1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full eye length and retinal ultra-widefield OCT. in Proc. SPIE 10416, pp. 104160J-104160J-6, 2017
    BibTeX Link
    @inproceedings{Kolb2017,
       author = {Kolb, J P; Klee, J; Pfeiffer, Tand Huber, R},
       title = {1060nm FDML laser with centimeter coherence length and 1.67 MHz sweep rate for full     eye length and retinal ultra-widefield OCT},
      booktitle = {Proc. SPIE} {10416},
    
      pages = {104160J-104160J-6},
      year = {2017},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       url = {http://dx.doi.org/10.1117/12.2286854},
       type = {Conference Proceedings}
    }
    

2016

  • Bliedtner, Katharina and Seifert, Eric and Stockmann, Leoni and Effe, Lisa and Brinkmann, Ralf: Towards real time speckle controlled retinal photocoagulation. no. 9693, pp. 96931A-96931A-6, 2016
    BibTeX Link
    @inproceedings{Bliedtner2016,
       author = {Bliedtner, Katharina and Seifert, Eric and Stockmann, Leoni and Effe, Lisa and Brinkmann, Ralf},
       title = {Towards real time speckle controlled retinal photocoagulation},
       volume = {9693},
       pages = {96931A-96931A-6},
       note = {10.1117/12.2212703},
       abstract = {Photocoagulation is a laser treatment widely used for the therapy of several retinal diseases. Intra- and inter-individual variations of the ocular transmission, light scattering and the retinal absorption makes it impossible to achieve a uniform effective exposure and hence a uniform damage throughout the therapy. A real-time monitoring and control of the induced damage is highly requested. Here, an approach to realize a real time optical feedback using dynamic speckle analysis is presented. A 532 nm continuous wave Nd:YAG laser is used for coagulation. During coagulation, speckle dynamics are monitored by a coherent object illumination using a 633nm HeNe laser and analyzed by a CMOS camera with a frame rate up to 1 kHz. It is obvious that a control system needs to determine whether the desired damage is achieved to shut down the system in a fraction of the exposure time. Here we use a fast and simple adaption of the generalized difference algorithm to analyze the speckle movements. This algorithm runs on a FPGA and is able to calculate a feedback value which is correlated to the thermal and coagulation induced tissue motion and thus the achieved damage. For different spot sizes (50-200 μm) and different exposure times (50-500 ms) the algorithm shows the ability to discriminate between different categories of retinal pigment epithelial damage ex-vivo in enucleated porcine eyes. Furthermore in-vivo experiments in rabbits show the ability of the system to determine tissue changes in living tissue during coagulation.},
       url = {http://dx.doi.org/10.1117/12.2212703},
       type = {Conference Proceedings},
    year = { 2016}
    }
    
  • Strauch, M and Urbach, H P: Surface harmonics on liquid lenses. in 2016 IEEE Photonics Conference (IPC), pp. 248-249, Oct, 2016
    BibTeX Link
    @INPROCEEDINGS{Strauch2017,
    author={Strauch, M and Urbach, H P},
    booktitle={2016 IEEE Photonics Conference (IPC)},
    title={Surface harmonics on liquid lenses},
    year={2016},
    
    pages={248-249},
    keywords={lenses;optical harmonic generation;optical tuning;oscillations;surface harmonics;liquid lenses;tunability;nonspherical surfaces;surface oscillations;Lenses;Liquids;Surface waves;Optical surface waves;Harmonic analysis;Shape;Optical switches},
    doi={10.1109/IPCon.2016.7831063},
    ISSN={},
    month={Oct},}
  • Kolb, Jan Philip and Klein, Thomas and Eibl, Matthias and Pfeiffer, Tom and Wieser, Wolfgang and Huber, Robert: Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm. in Proc. SPIE, no. 9697, pp. 969703-969703-8, 2016
    BibTeX Link
    @inproceedings{Kolb2016,
       author = {Kolb, Jan Philip and Klein, Thomas and Eibl, Matthias and Pfeiffer, Tom and Wieser, Wolfgang and Huber, Robert},
       title = {Megahertz FDML laser with up to 143nm sweep range for ultrahigh resolution OCT at 1050nm},
       booktitle = {Proc. SPIE},
       volume = {9697},
    
       pages = {969703-969703-8},
       year= { 2016}
       note = {10.1117/12.2214758},
       abstract = {We present a new design of a Fourier Domain Mode Locked laser (FDML laser), which provides a new record in sweep range at ~1μm center wavelength: At the fundamental sweep rate of 2x417 kHz we reach 143nm bandwidth and 120nm with 4x buffering at 1.67MHz sweep rate. The latter configuration of our system is characterized: The FWHM of the point spread function (PSF) of a mirror is 5.6μm (in tissue). Human in vivo retinal imaging is performed with the MHz laser showing more details in vascular structures. Here we could measure an axial resolution of 6.0μm by determining the FWHM of specular reflex in the image. Additionally, challenges related to such a high sweep bandwidth such as water absorption are investigated.},
       url = {http://dx.doi.org/10.1117/12.2214758},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
       type = {Conference Proceedings}
    }
    
  • Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon: Imaging vascular dynamics in human retina using full-field swept-source optical coherence tomography (Conference Presentation). no. 9697, pp. 96970E-96970E-1, 2016
    BibTeX Link
    @inproceedings{Spahr2016,
       author = {Spahr, Hendrik and Hillmann, Dierck and Hain, Carola and Pfäffle, Clara and Sudkamp, Helge and Franke, Gesa and Hüttmann, Gereon},
       title = {Imaging vascular dynamics in human retina using full-field swept-source optical coherence tomography (Conference Presentation)},
       volume = {9697},
       pages = {96970E-96970E-1},
       note = {10.1117/12.2214303},
       abstract = {We demonstrate a new non-invasive method to assess the functional condition of the retinal vascular system. Phase-sensitive full-field swept-source optical coherence tomography (PhS-FF-SS-OCT) is used to investigate retinal vascular dynamics at unprecedented temporal resolution. Motion of retinal tissue, that is induced by expansion of the vessels therein, is measured with an accuracy of about 10 nm. The pulse shape of arterial and venous pulsation, their temporal delay as well as the frequency dependent pulse propagation through the capillary bed are determined. For the first time, imaging speed and motion sensitivity are sufficient for a direct measurement of pulse waves propagating with more than 600 mm/s in retinal vessels of a healthy young subject.},
       url = {http://dx.doi.org/10.1117/12.2214303},
       type = {Conference Proceedings},
    year = { 2016}
    }
    
  • Pieper, Mario and Schulz-Hildebrandt, Hinnerk and Hüttmann, Gereon and König, Peter: Imaging of mucus clearance in the airways of living spontaneously breathing mice by optical coherence microscopy (Conference Presentation). no. 9691, pp. 969116-969116-1, 2016
    BibTeX Link
    @inproceedings{Pieper2016,
       author = {Pieper, Mario and Schulz-Hildebrandt, Hinnerk and Hüttmann, Gereon and König, Peter},
       title = {Imaging of mucus clearance in the airways of living spontaneously breathing mice by optical coherence microscopy (Conference Presentation)},
       volume = {9691},
       pages = {969116-969116-1},
    year = { 2016},
       note = {10.1117/12.2209054},
       abstract = {Mucus transport is essential to remove inhaled particles and pathogens from the lung. Impaired removal of mucus often results in worsening of lung diseases. To understand the mechanisms of mucus transport and to monitor the impact of therapeutic strategies, it is essential to visualize airways and mucus in living animals without disturbing transport processes by intubation or surgically opening the airways. We developed a custom-built optical coherence microscope (OCM) providing a lateral and axial resolution of approximately 1.5 µm with a field of view of 2 mm at up to 150 images/s. Images of the intact trachea and its mucus transport were recorded in anesthetized spontaneously breathing mice. NaCl solution (0.9% and 7%) or Lipopolysaccharide were applied intranasally. OCM resolved detailed structure of the trachea and enabled measuring the airway surface liquid (ASL) thickness through the tracheal wall. Without stimulation, the amount of ASL was only a few µm above the epithelium and remained constant. After intranasal application of 30 µl saline at different concentrations, an early fast cough-like fluid removal with velocities higher than 1 mm/s was observed that removed a high amount of liquid. The ASL thickness increased transiently and quickly returned to levels before stimulation. In contrast to saline, application of Lipopolysaccharide induced substantial mucus release and an additional slow mucus transport by ciliary beating (around 100 µm/s) towards the larynx was observed. In conclusion, OCM is appropriate unique tool to study mechanisms of mucus transport in the airways and effects of therapeutic interventions in living animals.},
       url = {http://dx.doi.org/10.1117/12.2209054},
       type = {Conference Proceedings}
    }