Proceedings

2008

  • Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert: Optical coherence tomography imaging with k-space linear Fourier Domain Mode Locked lasers. in 2008 Conference on Quantum Electronics and Laser Science Conference on Lasers and Electro-Optics, CLEO/QELS, 2008
    BibTeX Link
    @InProceedings{HU_2008_Eigenwillig_a,
      Title                    = {{Optical coherence tomography imaging with k-space linear Fourier Domain Mode Locked lasers}},
      Author                   = {Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert},
      Booktitle                = {2008 Conference on Quantum Electronics and Laser Science Conference on Lasers and Electro-Optics, CLEO/QELS},
      Year                     = {2008},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
    
      Url                      = {http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=4571261&searchWithin%3Deigenwillig%26sortType%3Dasc_p_Sequence%26filter%3DAND%28p_IS_Number%3A4571172%29}
    }
  • Just, T. and Lankenau, E. and Huettmann, G. and Pau, H.W.: Optical coherence tomography as a guide for cochlear implant surgery. in Progress in Biomedical Optics and Imaging, pp. F1-F6, SPIE 6842, 2008
    BibTeX Link
    @inproceedings{Just 2008,
       author = {Just, T. and Lankenau, E. and Huettmann, G. and Pau, H.W.},
       title = {Optical coherence tomography as a guide for cochlear implant surgery},
       booktitle = {Progress in Biomedical Optics and Imaging},
       editor = {Nikiforos, K. and Bernard, C. and Haishan, Z.},
       publisher = {SPIE 6842},
       pages = {F1-F6},
    url = { https://doi.org/10.1117/12.771446},
    year = { 2008}
    
    }
  • Adler, Desmond C and Chen, Yu and Huber, Robert and Schmitt, Joseph and Connolly, James and Fujimoto, James G: In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers. in Biomedical Optics (BiOS) 2008, pp. 684708-684708-7, International Society for Optics and Photonics, b,, 2008
    BibTeX Link Link
    @InProceedings{HU_2008_Adler_b,
      Title                    = {{In vivo endomicroscopy using three-dimensional optical coherence tomography and Fourier domain mode locked lasers}},
      Author                   = {Adler, Desmond C and Chen, Yu and Huber, Robert and Schmitt, Joseph and Connolly, James and Fujimoto, James G},
      Booktitle                = {Biomedical Optics (BiOS) 2008},
      Year                     = {2008},
      Editor                   = {Izatt, Joseph A and Fujimoto, James G and Tuchin, Valery V},
      Month                    = feb,
      Pages                    = {684708--684708--7},
      Publisher                = {International Society for Optics and Photonics},
    
      Doi                      = {10.1117/12.761850},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
      Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1326810}
    }
    
  • Jirauschek, Christian and Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert: Fourier domain mode locking theory. in 2008 Conference on Quantum Electronics and Laser Science Conference on Lasers and Electro-Optics, CLEO/QELS, 2008
    BibTeX Link
    @InProceedings{HU_2008_Jirauschek_a,
      Title                    = {{Fourier domain mode locking theory}},
      Author                   = {Jirauschek, Christian and Eigenwillig, Christoph and Biedermann, Benjamin and Huber, Robert},
      Booktitle                = {2008 Conference on Quantum Electronics and Laser Science Conference on Lasers and Electro-Optics, CLEO/QELS},
      Year                     = {2008},
    keywords = {AG-Huber_FDML},
    
      Url                      = {http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=4571888&searchWithin%3Deigenwillig%26sortType%3Dasc_p_Sequence%26filter%3DAND%28p_IS_Number%3A4571172%29}
    }
  • Steven, Philip and Koop, Norbert and Huttmann, Gereon: Confocal microscopy versus two-photon microscopy: imaging of ocular surface pathologies. no. 6860, pp. 686023, SPIE, 2008
    BibTeX
    @inproceedings{Steven 2008,
       author = {Steven, Philip and Koop, Norbert and Huttmann, Gereon},
       title = {Confocal microscopy versus two-photon microscopy: imaging of ocular surface pathologies},
       editor = {Ammasi, Periasamy and Peter, T. C. So},
       publisher = {SPIE},
       volume = {6860},
       pages = {686023},
    year = { 2008}
    }

2007

  • Adler, Desmond C and Huber, Robert and Fujimoto, James G: Phase-sensitive optical coherence tomography using buffered Fourier domain mode-locked lasers at up to 370,000 scans per second. in Biomedical Optics (BiOS) 2007, pp. 64291L-64291L-9, International Society for Optics and Photonics, b,, 2007
    BibTeX Link Link
    @InProceedings{HU_2007_Adler_d,
      Title                    = {{Phase-sensitive optical coherence tomography using buffered Fourier domain mode-locked lasers at up to 370,000 scans per second}},
      Author                   = {Adler, Desmond C and Huber, Robert and Fujimoto, James G},
      Booktitle                = {Biomedical Optics (BiOS) 2007},
      Year                     = {2007},
      Editor                   = {Fujimoto, James G and Izatt, Joseph A and Tuchin, Valery V},
      Month                    = feb,
      Pages                    = {64291L--64291L--9},
      Publisher                = {International Society for Optics and Photonics},
    
      Doi                      = {10.1117/12.704128},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
      Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1334093}
    }
  • Theisen-Kunde, D and Tedsen, S and Danicke, V and Herrmann, K and Brinkmann, R: Partial kidney resection by use of a 1,94 µm thulium fiber laser. in Proc ECBO, no. 6632, SPIE, 2007
    BibTeX Link
    @inproceedings{Theisen-Kunde2007,
       author = {Theisen-Kunde, D and Tedsen, S and Danicke, V and Herrmann, K and Brinkmann, R},
       title = {Partial kidney resection by use of a 1,94 µm thulium fiber laser},
       booktitle = {Proc ECBO},
       series = {Therapeutic Laser Applications and Laser-Tissue Interactions},
       publisher = {SPIE},
       volume = {6632},
       type = {Conference Proceedings},
    year = { 2007},
    url = { https://doi.org/10.1007/978-3-540-68764-1_72}
    }
    
  • Schlott, Kerstin and Stalljohann, Jens and Weber, Benjamin and Kandulla, Jochen and Herrmann, Katharina and Birngruber, Reginald and Brinkmann, Ralf: Optoacoustic online temperature determination during retinal laser photocoagulation. no. 6632, pp. 66321B-66321B-8, 2007
    BibTeX Link
    @inproceedings{Schlott2007,
       author = {Schlott, Kerstin and Stalljohann, Jens and Weber, Benjamin and Kandulla, Jochen and Herrmann, Katharina and Birngruber, Reginald and Brinkmann, Ralf},
       title = {Optoacoustic online temperature determination during retinal laser photocoagulation},
       volume = {6632},
       pages = {66321B-66321B-8},
       note = {10.1117/12.728291},
       abstract = {Retinal photocoagulation is an established treatment of different retinal diseases. The treatment relies on a short, local heating of the tissue which induces a denaturation. The resulting scar formation may for example prevent the further detachment of the retina. The extent of the coagulation is besides other parameters mostly dependent on the induced temperature increase. However, until today a temperature based dosimetry for photocoagulation does not exist. The dosage is rather based on the experience of the treating physicians to achieve visible whitish lesions on the retina. In this work a technique is presented, which allows an online temperature monitoring during photocoagulation. If an absorbing material is irradiated with short laser pulses, a thermoelastic expansion of the absorber induces an acoustic wave. Its amplitude is dependent on the temperature of the absorber. For analyzing the applicability of the optoacoustic temperature determination for dosimetry, measurements were performed on enucleated porcine eye globes. The pressure transients are detected by an ultrasonic transducer, which is embedded in an ophthalmologic contact lens. As long as no strong lesions occur, the determined temperatures are almost proportional to the power of the treatment laser. Using a spot diameter of 200 μm and different laser powers, the temperature rise at the end of the 400 ms irradiation was found to be approximately 0.16 °C/mW. The onset of the denaturation was observed around 50°C. The far aim of this project is an automatic regulation of the treatment laser onto a desired temperature course.},
       url = {http://dx.doi.org/10.1117/12.728291},
       type = {Conference Proceedings},
    year = { 2007}
    }
    
  • Adler, Desmond C and Huber, Robert and Fujimoto, James G: Optical coherence tomography phase microscopy using buffered fourier domain mode locked (FDML) lasers at up to 370,000 lines per second. in Conference on Lasers and Electro-Optics, 2007, CLEO 2007, 2007
    BibTeX Link
    @InProceedings{HU_2007_Adler_e,
      Title                    = {{Optical coherence tomography phase microscopy using buffered fourier domain mode locked (FDML) lasers at up to 370,000 lines per second}},
      Author                   = {Adler, Desmond C and Huber, Robert and Fujimoto, James G},
      Booktitle                = {Conference on Lasers and Electro-Optics, 2007, CLEO 2007},
      Year                     = {2007},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
    
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?uri=CLEO-2007-CFL1}
    }
  • Qu, Xiaochao and Norbert, Koop and Li, Zheng and Wang, Jing and Zhang, Zhenxi and Hüttmann, Gereon: Multiphoton fluorescence lifetime imaging of Karpas 299 cells using ACT1 antibody conjugated gold nanoparticles. no. 6630, pp. 66301C-66301C-8, 2007
    BibTeX Link
    @inproceedings{Qu2007,
       author = {Qu, Xiaochao and Norbert, Koop and Li, Zheng and Wang, Jing and Zhang, Zhenxi and Hüttmann, Gereon},
       title = {Multiphoton fluorescence lifetime imaging of Karpas 299 cells using ACT1 antibody conjugated gold nanoparticles},
       volume = {6630},
       pages = {66301C-66301C-8},
       note = {10.1117/12.728239},
       abstract = {Due to the unique optical properties, gold nanoparticles (NPs) can play a useful role in biological cellular imaging as biological probes. Using multiphoton microscopy and fluorescence lifetime imaging (FLIM) system, we recorded the images of Karpas 299 cells incubated without, or with gold NPs, and ACT1 antibodies conjugated with gold NPs. From the FLIM, we can easily discriminate the difference among different experiment conditions due to the distinct lifetime between cells and gold NPs. Our results present that nonconjugated gold NPs are accumulated inside cells, but conjugated gold NPs bind homogeneously and specifically to the surface of cancer cells. For single Karpas 299 cells, the signal is very week when the excitation power is about 10mw; while the power is approximately 28 mw, a very sharp cell imaging can be obtained. For the Karpas 299 incubated with ACT1 conjugated gold NPs, while the excitation power is 10mw, gold NPs have clear fluorescence signal so that the profile of cells can be detected; Signal of gold NPs is very strong when the power arrived in 20mw. These results suggest that the multiphoton lifetime imaging of antibody conjugated gold NPs can support a useful method in diagnosis of cancer.},
       url = {http://dx.doi.org/10.1117/12.728239},
       type = {Conference Proceedings},
    year = { 2007}
    }
    
  • Stoehr, Hardo and Ptaszynski, Lars and Fritz, Andreas and Brinkmann, Ralf: Interferometric optical online dosimetry for selective retina treatment (SRT). no. 6426, pp. 642619-642619-7, 2007
    BibTeX Link
    @inproceedings{Stoehr2007-1,
       author = {Stoehr, Hardo and Ptaszynski, Lars and Fritz, Andreas and Brinkmann, Ralf},
       title = {Interferometric optical online dosimetry for selective retina treatment (SRT)},
       volume = {6426},
       pages = {642619-642619-7},
       note = {10.1117/12.708521},
       abstract = {In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.},
       url = {http://dx.doi.org/10.1117/12.708521},
       type = {Conference Proceedings},
    Year = { 2007}
    }
    
  • Herrmann, Katharina and Flöhr, Christian and Stalljohann, Jens and Apiou-Sbirlea, Gabriela and Kandulla, Jochen and Birngruber, Reginald and Brinkmann, Ralf: Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments. no. 6632, pp. 66321D-66321D-7, 2007
    BibTeX Link
    @inproceedings{Herrmann2007,
       author = {Herrmann, Katharina and Flöhr, Christian and Stalljohann, Jens and Apiou-Sbirlea, Gabriela and Kandulla, Jochen and Birngruber, Reginald and Brinkmann, Ralf},
       title = {Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments},
       volume = {6632},
       pages = {66321D-66321D-7},
       note = {10.1117/12.728222},
       abstract = {In most retinal laser treatments the therapeutic effect is initiated by a transient temperature increase at and around the retinal pigment epithelium (RPE). Especially in long exposure time treatments like Transpupillary Thermotherapy (TTT) choroidal perfusion has a strong influence on the realized temperature at the fundus. The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here. In order to reduce the choroidal perfusion, the IOP is increased by injection of physiological saline solution into the eye of anaesthetized rabbits. The fundus is irradiated with 3.64 W/cm2 by means of a TTT-laser (λ = 810 nm) for t = 20 s causing a retinal temperature increase. Realtime temperature determination at the irradiated spot is achieved by a non invasive optoacoustic technique. Perfusion can be reduced by increasing IOP, which leads to different temperature increases when irradiating the retina. This should be considered for long time laser treatments.},
       url = {http://dx.doi.org/10.1117/12.728222},
       type = {Conference Proceedings},
    year = { 2007}
    }
    
  • Huber, Robert A and Adler, Desmond C and Srinivasan, Vivek J and Gorczynska, Iwona M and Fujimoto, James G: Fourier domain mode-locked (FDML) lasers at 1050 nm and 202,000 sweeps per second for OCT retinal imaging. in Proceedings of SPIE, no. 6429, pp. 642907-642907-7, b,, 2007
    BibTeX Link Link
    @InProceedings{HU_2007_Huber_c,
      Title                    = {{Fourier domain mode-locked (FDML) lasers at 1050 nm and 202,000 sweeps per second for OCT retinal imaging}},
      Author                   = {Huber, Robert A and Adler, Desmond C and Srinivasan, Vivek J and Gorczynska, Iwona M and Fujimoto, James G},
      Booktitle                = {Proceedings of SPIE},
      Year                     = {2007},
      Editor                   = {Fujimoto, James G and Izatt, Joseph A and Tuchin, Valery V},
      Month                    = feb,
      Pages                    = {642907--642907--7},
      Volume                   = {6429},
    
      Doi                      = {10.1117/12.704084},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
      Url                      = {http://proceedings.spiedigitallibrary.org/proceeding.aspx?articleid=1296450}
    }
  • Huber, Robert and Srinivasan, Vivek J and Adler, Desmond C and Gorczynska, I and Fujimoto, James G: Fourier Domain Mode Locking (FDML) in the non-zero dispersion regime: A laser for ultrahigh-speed retinal OCT imaging at 236kHz line rate. in Conference on Lasers and Electro-Optics, 2007, CLEO 2007, 2007
    BibTeX Link
    @InProceedings{HU_2007_Huber_b,
      Title                    = {{Fourier Domain Mode Locking (FDML) in the non-zero dispersion regime: A laser for ultrahigh-speed retinal OCT imaging at 236kHz line rate}},
      Author                   = {Huber, Robert and Srinivasan, Vivek J and Adler, Desmond C and Gorczynska, I and Fujimoto, James G},
      Booktitle                = {Conference on Lasers and Electro-Optics, 2007, CLEO 2007},
      Year                     = {2007},
    keywords = {AG-Huber_FDML, AG-Huber_OCT},
    
      Url                      = {http://www.opticsinfobase.org/abstract.cfm?uri=CLEO-2007-CThAA5}
    }
  • Fritz, Andreas and Ptaszynski, Lars and Stoehr, Hardo and Brinkmann, Ralf: Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE). no. 6632, pp. 66321C-66321C-11, 2007
    BibTeX Link
    @inproceedings{Fritz2007-1,
       author = {Fritz, Andreas and Ptaszynski, Lars and Stoehr, Hardo and Brinkmann, Ralf},
       title = {Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE)},
       volume = {6632},
       pages = {66321C-66321C-11},
       note = {10.1117/12.728344},
       abstract = {Selective Retina Treatment (SRT) is a new method to treat eye diseases associated with disorders of the RPE. Selective RPE cell damage is achieved by applying a train of 1.7 μs laser pulses at 527 nm. The treatment of retinal diseases as e.g. diabetic maculopathy (DMP), is currently investigated within clinical studies, however 200 ns pulse durations are under investigation. Transient micro bubbles in the retinal pigment epithelium (RPE) are expected to be the origin of cell damage due to irradiation with laser pulses shorter than 50 μs. The bubbles emerge at the strongly absorbing RPE melanosomes. Cell membrane disruption caused by the transient associated volume increase is expected to be the origin of the angiographically observed RPE leakage. We investigate micro bubble formation and dynamics in porcine RPE using pulse durations of 150 ns. A laser interferometry system at 830 nm with the aim of an online dosimetry control for SRT was developed. Bubble formation was detected interferometrically and by fast flash photography. A correlation to cell damage observed with a vitality stain is found. A bubble detection algorithm is presented.},
       url = {http://dx.doi.org/10.1117/12.728344},
       type = {Conference Proceedings},
    Year = { 2007}
    }