2020
Tobias
Fischer,
Antje
Klinger,
Dorthe
Smolinski,
Regina
Orzekowsky-Schröder,
Falk
Nitzsche,
Alfred
Vogel,
Gereon
Hüttmann, and
Andreas
Gebert,
High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , pp. 1-8, 2020.
High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , pp. 1-8, 2020.
Datei: | s00441-020-03167-z |
Bibtex: | @article{Fischer2020, author = {Fischer, T;Klinger, A;von Smolinski, D;Orzekowsky-Schroeder, R;Nitzsche, F;Bölke, T;Vogel, A;Hüttmann, G and Gebert, A}, title = {High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures}, journal = {Cell and Tissue Research}, pages = {1-8}, ISSN = {1432-0878}, url = {https://doi.org/10.1007/s00441-020-03167-z}, year = {2020}, type = {Journal Article} } |
Vasily
Matkivsky,
Alexander
Moiseev,
Pavel
Shilyagin,
Alexander
Rodionov,
Hendrik
Spahr,
Clara
Pfäffle,
Gereon
Hüttmann,
Dierck
Hillmann, and
Grigory
Gelikonov,
Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function, Journal of Biophotonics , vol. 13(10), pp. e202000112, 2020.
Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function, Journal of Biophotonics , vol. 13(10), pp. e202000112, 2020.
DOI: | 10.1002/jbio.202000112 |
Bibtex: | @article{Matkivsky2020, author = {Matkivsky, V;Moiseev, A;Shilyagin, P;Rodionov, A;Spahr, H;Pfäffle, C;Hüttmann, G;Hillmann, D and Gelikonov, G}, title = {Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function}, journal = {Journal of Biophotonics}, volume = {13(10)}, pages = {e202000112}, ISSN = {1864-063X}, DOI = {10.1002/jbio.202000112}, year = {2020}, type = {Journal Article} } |
Asylkhan E.
Rakhymzhan,
Lucie
Reuter,
Raphael
Raspe,
Daniel
Bremer,
Judith
Heidelin,
Volker
Andresen,
Robert
Günther,
Ruth
Leben,
Sergey
Cheremukhin,
Hinnerk
Schulz-Hildebrandt,
Maria G.
Bixel,
Ralf H.
Adams,
Helena
Radbruch,
Gereon
Hüttmann,
Anja E.
Hauser, and
Raluca A.
Niesner,
Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging, Cytometry Part A , vol. 97, no. 5, pp. 515-527, 2020.
Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging, Cytometry Part A , vol. 97, no. 5, pp. 515-527, 2020.
DOI: | 10.1002/cyto.a.24012 |
Bibtex: | @article{Schulz-Hildebrandt-2020, author = {Rakhymzhan, A;Reuter, L;Raspe, R;Bremer, D;Günther, R;Leben, R;Heidelin, J;Andresen, V;Cheremukhin, S;Schulz-Hildebrandt, H;Bixel, M G.;Adams, R H.;Radbruch, H;Hüttmann, G;Hauser, A E. and Niesner, R A.}, title = {Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging}, year = {2020}, journal = {Cytometry Part A}, volume = {97}, number = {5}, pages={515-527}, ISSN = {1552-4922}, DOI = {10.1002/cyto.a.24012}, type = {Journal Article} } |
Cuiping
Yao,
Florian
Rudnitzki,
Yida
He,
Zhenxi
Zhang,
Gereon
Hüttmann, and
Ramtin
Rahmanzadeh,
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
DOI: | 10.1002/jbio.202000017 |
Bibtex: | @article{Rahmanzadeh-2020, author = {Yao, C;Rudnitzki, F;He, Y;Zhang, Z;Hüttmann, G and Rahmanzadeh, R}, title = {Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods}, journal = {JBio}, ISSN = {1864-063X}, DOI = {10.1002/jbio.202000017}, Year = {2020}, type = {Journal Article} } |
Hartmut
Schneider,
Martin
Ahrens,
Michaela
Strumpski,
Claudia
Rüger,
Matthias
Häfer,
Gereon
Hüttmann,
Dirk
Theisen-Kunde,
Hinnerk
Schulz-Hildebrandt, and
Rainer
Haak,
An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations, J Clin Med , vol. 9(10), 2020.
An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations, J Clin Med , vol. 9(10), 2020.
DOI: | 10.3390/jcm9103257 |
Bibtex: | @article{schneider2020, author = {Schneider, H.;Ahrens, M.;Strumpski, M.;Ruger, C.;Hafer, M.;Huettmann, G.;Theisen-Kunde, D.;Schulz-Hildebrandt, H. and Haak, R.}, title = {An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations}, journal = {J Clin Med}, volume = {9(10)}, keywords = {OCT; intraoral probe; carious lesions; caries diagnosis; dental restorations}, ISSN = {2077-0383 (Print) 2077-0383 (Linking)}, DOI = {10.3390/jcm9103257}, year = {2020}, type = {Journal Article} } |
2019
Marco
Horn,
Sonja
Jäckle,
Felix
von Haxthausen,
Tim
Eixmann,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann,
Juljan
Bouchagiar,
Florian
Matysiak,
Mark
Kaschwich,
Markus
Kleemann,
Floris
Ernst,
Veronica
Garcia-Vazquez, and
Torben
Pätz,
First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures, European Journal of Vascular and Endovascular Surgery , vol. 58, no. 6, pp. e610--e611, Dez. 2019. W.B. Saunders.
First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures, European Journal of Vascular and Endovascular Surgery , vol. 58, no. 6, pp. e610--e611, Dez. 2019. W.B. Saunders.
DOI: | 10.1016/J.EJVS.2019.09.091 |
Bibtex: | @proceedings{Horn2019b, title = {First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures}, author = {Marco Horn and Sonja J\"{a}ckle and Felix von Haxthausen and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Juljan Bouchagiar and Florian Matysiak and Mark Kaschwich and Markus Kleemann and Floris Ernst and Ver\'{o}nica Garc\'{i}a-V\'{a}zquez and Torben P\"{a}tz}, doi = {10.1016/J.EJVS.2019.09.091}, issn = {1078-5884}, year = {2019}, date = {2019-12-13}, journal = {European Journal of Vascular and Endovascular Surgery}, volume = {58}, number = {6}, pages = {e610--e611}, publisher = {W.B. Saunders}, keywords = {Sensing, Fiber}, pubstate = {published}, tppubtype = {proceedings} } |
Hendrik
Spahr,
Clara
Pfäffle,
Sazan
Burhan,
Lisa
Kutzner,
Felix
Hilge,
Gereon
Hüttmann, and
Dierck
Hillmann,
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific report , vol. 9, 08 2019.
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific report , vol. 9, 08 2019.
DOI: | 10.1038/s41598-019-47979-8 |
Bibtex: | @article{RN5217, author = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck}, title = {Phase-sensitive interferometry of decorrelated speckle patterns}, journal = {Scientific Reports}, volume = {9}, number = {1}, pages = {11748}, ISSN = {2045-2322}, DOI = {10.1038/s41598-019-47979-8}, url = {https://doi.org/10.1038/s41598-019-47979-8}, year = {2019}, type = {Journal Article} } |
Hendrik
Spahr,
Clara
Pfäffle,
Gereon
Hüttmann, and
Dierck
Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt. Lett. , vol. 44, no. 6, pp. 1315--1318, 03 2019. Optica Publishing Group.
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt. Lett. , vol. 44, no. 6, pp. 1315--1318, 03 2019. Optica Publishing Group.
DOI: | 10.1364/OL.44.001315 |
Datei: | abstract.cfm |
Bibtex: | @article{RN5085, author = {Spahr, H;Pfäffle, C;Hüttmann, G and Hillmann, D}, title = {Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion}, journal = {Optics letters}, volume = {44(5)}, pages = {1315-1318}, DOI = {https://doi.org/10.1364/OL.44001315}, url = {https://doi.org/10.1364/OL.44001315}, year = {2019}, type = {Journal Article} } |
Ramtin
Rahmanzadeh,
Florian
Rudnitzki, and
Gereon
Hüttmann,
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
DOI: | 10.1002/jbio.201800460 |
Datei: | jbio.201800460 |
Bibtex: | @article{Rahmanzadeh-2019, author = {Rahmanzadeh, R;Rudnitzki, F and Hüttmann, G}, title = {Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes}, journal = {Journal of Biophotonics}, Year = {2019}, pages = {e201800460}, ISSN = {1864-063X}, DOI = {10.1002/jbio.201800460}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201800460}, type = {Journal Article} } |
Clara
Pfäffle,
Hendrik
Spahr,
Lisa
Kutzner,
Sazan
Burhan,
Felix
Hilge,
Yoko
Miura,
Gereon
Hüttmann, and
Dierck
Hillmann,
Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina, Optics Letters 44(23) , pp. 5671-5674, 2019.
Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina, Optics Letters 44(23) , pp. 5671-5674, 2019.
DOI: | 10.1364/OL.44.005671 |
Bibtex: | @article{Pfäffle2019, author = {Pfäffle, C;Spahr, H;Kutzner, L;Burhan, S;Hilge, F;Miura, Y;Hüttmann, G and Hillmann, D}, title = {Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina}, journal = {Optics Letters 44(23)}, pages = {5671-5674}, DOI = {10.1364/OL.44.005671}, year = {2019}, type = {Journal Article} } |
Timo
Kepp,
Christine
Droigk,
Malte
Casper,
Michael
Evers,
Gereon
Hüttmann,
Nunciada
Salma,
Dieter
Manstein,
Matthias P.
Heinrich, and
Heinz
Handels,
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks, Biomed Opt Expr 10(7) , pp. 3484-3496, 2019.
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks, Biomed Opt Expr 10(7) , pp. 3484-3496, 2019.
DOI: | 10.1364/BOE.10.003484 |
Datei: | BOE.10.003484 |
Bibtex: | @article{Hüttmann2019, author = {Kepp, T;Droigk, C;Casper, M;Evers, M;Hüttmann, G;Salma, N;Manstein, D;Heinrich, M P. and Handels, H}, title = {Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks}, journal = {Biomed Opt Expr 10(7)}, pages = {3484-3496}, DOI = {10.1364/BOE.10.003484}, url = {https://doi.org/10.1364/BOE.10.003484}, year = {2019}, type = {Journal Article} } |
Dierck
Hillmann,
Clara
Pfäffle,
Hendrik
Spahr,
Helge
Sudkamp,
Gesa
Franke, and
Gereon
Hüttmann,
In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 181-194.
In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 181-194.
ISBN: | 978-3-030-16638-0 |
Datei: | 978-3-030-16638-0_8 |
Bibtex: | @inbook{Hillmann2019, author = {Hillmann, Dierck;Pfäffle, Clara;Spahr, Hendrik;Sudkamp, Helge;Franke, Gesa and Hüttmann, Gereon}, title = {In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells}, booktitle = {High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics}, editor = {Bille, Josef F.}, publisher = {Springer International Publishing}, address = {Cham}, pages = {181-194}, ISBN = {978-3-030-16638-0}, url = {https://doi.org/10.1007/978-3-030-16638-0_8}, year = {2019}, type = {Book Section} } |
Tabea
Kohlfaerber,
Ding
Shujun,
Ramtin
Rahmanzadeh,
Thomas
Jüngst,
Jürgen
Groll,
Hinnerk
Schulz-Hildebrandt, and
Gereon
Hüttmann,
Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT, Transactions on Additive Manufacturing Meets Medicine 1(1) , 2019.
Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT, Transactions on Additive Manufacturing Meets Medicine 1(1) , 2019.
DOI: | 10.18416/AMMM.2019.1909S03P19 |
Bibtex: | @article{Kohlfärber2019, author = {Kohlfaerber, T;Ding, S;Rahmanzadeh, R;Jüngst, T;Groll, J;Schulz-Hildebrandt, H and Hüttmann, G}, title = {Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT}, journal = {Transactions on Additive Manufacturing Meets Medicine 1(1)}, DOI = {10.18416/AMMM.2019.1909S03P19}, year = {2019}, type = {Journal Article} } |
Tobias
Fischer,
Antje
Klinger,
Dorthe
Smolinski,
Regina
Orzekowsky-Schroeder,
Falk
Nitzsche,
Alfred
Vogel,
Gereon
Hüttmann, and
Andreas
Gebert,
High-resolution imaging of the living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , 2019.
High-resolution imaging of the living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , 2019.
Dierck
Hillmann,
Clara
Pfäffle,
Hendrik
Spahr,
Sazan
Burhan,
Lisa
Kutzner,
Felix
Hilge, and
Gereon
Hüttmann,
Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations, Opt Lett 44 (15) , pp. 3905-3908, 2019.
Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations, Opt Lett 44 (15) , pp. 3905-3908, 2019.
DOI: | 10.1364/OL.44.003905 |
Datei: | 31368998 |
Bibtex: | @article{Hillmann2019, author = {Hillmann, D.;Pfaffle, C.;Spahr, H.;Burhan, S.;Kutzner, L.;Hilge, F. and Hüttmann, G.}, title = {Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations}, journal = {Opt Lett 44 (15)}, pages = {3905-3908}, ISSN = {1539-4794 (Electronic) 0146-9592 (Linking)}, DOI = {10.1364/OL.44.003905}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31368998}, year = {2019}, type = {Journal Article} } |
2018
Hinnerk
Schulz-Hildebrandt,
Tom
Pfeiffer,
Tim
Eixmann,
Sabrina
Lohmann,
Martin
Ahrens,
Josua
Rehra,
Wolfgang
Draxinger,
Peter
König,
Robert
Huber, and
Gereon
Hüttmann,
High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography, Opt. Lett. , vol. 43, no. 18, pp. 4386-4389, 09 2018. Optica Publishing Group.
High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography, Opt. Lett. , vol. 43, no. 18, pp. 4386-4389, 09 2018. Optica Publishing Group.
DOI: | 10.1364/OL.43.004386 |
Bibtex: | @article{Schulz-Hildebrandt:18, author = {Hinnerk Schulz-Hildebrandt and Tom Pfeiffer and Tim Eixmann and Sabrina Lohmann and Martin Ahrens and Joshua Rehra and Wolfgang Draxinger and Peter K\"{o}nig and Robert Huber and Gereon H\"{u}ttmann}, journal = {Opt. Lett.}, keywords = {Fiber optics imaging; Endoscopic imaging; Medical and biological imaging; Optical coherence tomography; Fourier domain mode locking; Image quality; Optical coherence tomography; Single mode fibers; Step index fibers; Three dimensional imaging}, number = {18}, pages = {4386--4389}, publisher = {Optica Publishing Group}, title = {High-speed fiber scanning endoscope for volumetric multi-megahertz optical coherence tomography}, volume = {43}, month = {Sep}, year = {2018}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-43-18-4386}, doi = {10.1364/OL.43.004386}, abstract = {We present a forward-viewing fiber scanning endoscope (FSE) for high-speed volumetric optical coherence tomography (OCT). The reduction in size of the probe was achieved by substituting the focusing optics by an all-fiber-based imaging system which consists of a combination of scanning single-mode fibers, a glass spacer, made from a step-index multi-mode fiber, and a gradient-index fiber. A lateral resolution of 11 $\mu$m was achieved at a working distance of 1.2 mm. The newly designed piezo-based FSE has an outer diameter of 1.6 mm and a rigid length of 13.5 mm. By moving the whole imaging optic in spirals for scanning the sample, the beam quality remains constant over the entire field of view with a diameter of 0.8 mm. The scanning frequency was adjusted to 1.22 kHz for use with a 3.28 MHz Fourier domain mode locked OCT system. Densely sampled volumes have been imaged at a rate of 6 volumes per second.}, } |
Helge
Sudkamp,
Dierck
Hillmann,
Peter
Koch,
Malte
vom Endt,
Hendrik
Spahr,
Michael
Münst,
Clara
Pfäffle,
Reginald
Birngruber, and
Gereon
Hüttmann,
Simple approach for aberration-corrected OCT imaging of the human retina, Opt Lett , vol. 43, no. 17, pp. 4224, 08 2018.
Simple approach for aberration-corrected OCT imaging of the human retina, Opt Lett , vol. 43, no. 17, pp. 4224, 08 2018.
DOI: | 10.1364/ol.43.004224 |
Bibtex: | @article{Sudkamp2018a, author = {Sudkamp, H; Hillmann, D; Koch, P;vom Endt, M; Spahr, H; Münst, M; Pfäffle, C; Birngruber, R and Hüttmann, G}, title = {Simple approach for aberration-corrected OCT imaging of the human retina}, journal = {Opt Lett}, pages = {4224}, ISSN = {0146-9592 1539-4794}, DOI = {10.1364/ol.43.004224}, year = {2018}, type = {Journal Article}, keyword = {Retome} } |
J
Rudnitzki, and
G
Huettmann,
siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase, Journal of BIOPHOTONICS , 2018.
siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase, Journal of BIOPHOTONICS , 2018.
DOI: | 10.1002/jbio.201700329 |
Bibtex: | @article{Rahmanzadeh2018, author = {Rudnitzki, F; Feineis, S; Rahmanzadeh, R; Endl, E; Lutz, J; Groll, J and Huettmann, G}, title = {siRNA release from gold nanoparticles by nanosecond pulsed laser irradiation and analysis of the involved temperature increase}, journal = {Journal of BIOPHOTONICS}, doi = {10.1002/jbio.201700329}, keywords = {cavitation|cell manipulation|controlled release|gold nanoparticle bio-conjugates|laser nanoeffects}, abstract = {Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particle and near the surface were calculated for the different radiant exposures. Upon irradiation with laser pulses of 4 nanosecond duration release started for both particle sizes at a calculated temperature increase of approximately 500 K. Maximum coumarin release was observed for 15 nm particles after irradiation with radiant exposure of 80 mJ cm−2 and with 32 mJ cm−2 for 30 nm particles. This corresponds to a temperature increase of 815 and 900 K, respectively. Our results show that the molecular release by nanosecond pulsed irradiation is based on a different mechanism compared to continuous or femtosecond irradiation. Local temperatures are considerably higher and it is expected that bubble formation plays a crucial role in release and damage to cellular structures. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim}, year = {2018}, type = {Journal Article} } |
Hinnerk
Schulz-Hildebrandt,
Mario
Pieper,
Martin
Ahrens,
Christian
Idel,
Barbara
Wollenberg,
Peter
König, and
Gereon
Hüttmann,
Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography, Biomedical Optics Express , pp. 636-647, 2018.
Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography, Biomedical Optics Express , pp. 636-647, 2018.
DOI: | 10.1364/BOE.9.000636 |
Datei: | abstract.cfm |
Bibtex: | @article{schulz2018novel, title = {Novel endoscope with increased depth of field for imaging human nasal tissue by microscopic optical coherence tomography}, author = {Schulz-Hildebrandt, H; Pieper, M; Stehmar,C; Ahrens, M; Idel, C; Wollenberg,B; K\"{o}nig,P and Gereon H\"{u}ttmann}, editor = {Optic Socie Amer}, url = {https://www.osapublishing.org/abstract.cfm?URI=boe-9-2-636 https://www.osapublishing.org/boe/viewmedia.cfm?uri=boe-9-2-636&seq=0}, doi = {10.1364/BOE.9.000636}, isbn = {10.1364/BOE.9.000636}, year = {2018}, date = {2018-01-16}, journal = {Biomedical Optics Express}, pages = {636-647}, abstract = {Intravital microscopy (IVM) offers the opportunity to visualize static and dynamic changes of tissue on a cellular level. It is a valuable tool in research and may considerably improve clinical diagnosis. In contrast to confocal and non-linear microscopy, optical coherence tomography (OCT) with microscopic resolution (mOCT) provides intrinsically cross-sectional imaging. Changing focus position is not needed, which simplifies especially endoscopic imaging. For in-vivo imaging, here we are presenting endo-microscopic OCT (emOCT). A graded-index-lens (GRIN) based 2.75 mm outer diameter rigid endoscope is providing 1.5 \textendash 2 μm nearly isotropic resolution over an extended field of depth. Spherical and chromatic aberrations are used to elongate the focus length. Simulation of the OCT image formation, suggests overall a better image quality in this range compared to a focused Gaussian beam. Total imaging depth at a reduced sensitivity and lateral resolution is more than 200 μm. Using a frame rate of 80 Hz cross-sectional images of concha nasalis were demonstrated in humans, which could resolve cilial motion, cellular structures of the epithelium, vessels and blood cells. Mucus transport velocity was determined successfully. The endoscope may be used for diagnosis and treatment control of different lung diseases like cystic fibrosis or primary ciliary dyskinesia, which manifest already at the nasal mucosa.}, keywords = {Endoskope, OCM}, pubstate = {published}, tppubtype = {article} } |
Hinnerk
Schulz-Hildebrandt,
Michael
Münter,
Martin
Ahrens,
Hendrik
Spahr,
Dierck
Hillmann,
Peter
König, and
Gereon
Hüttmann,
Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations, in 2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources , 2018. pp. 105910O.
Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations, in 2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources , 2018. pp. 105910O.
DOI: | 10.1117/12.2303755 |
ISBN: | 9781510616745 |
Bibtex: | @inproceedings{Schulz-Hildebrandt2018a, title = {Coherence and diffraction limited resolution in microscopic OCT by a unified approach for the correction of dispersion and aberrations}, author = {Schulz-Hildebrandt,H; M\"{u}nter, M; Ahrens,M; Spahr, H; Hillmann, D; K\"{o}nig, P and H\"{u}ttmann, G}, doi = {10.1117/12.2303755}, isbn = {9781510616745}, year = {2018}, date = {2018-03-05}, booktitle = {2nd Canterbury Conference on OCT with Emphasis on Broadband Optical Sources}, volume = {10591}, pages = {105910O}, abstract = {Optical coherence tomography (OCT) images scattering tissues with 5 to 15 μm resolution. This is usually not sufficient for a distinction of cellular and subcellular structures. Increasing axial and lateral resolution and compensation of artifacts caused by dispersion and aberrations is required to achieve cellular and subcellular resolution. This includes defocus which limit the usable depth of field at high lateral resolution. OCT gives access the phase of the scattered light and hence correction of dispersion and aberrations is possible by numerical algorithms. Here we present a unified dispersion/aberration correction which is based on a polynomial parameterization of the phase error and an optimization of the image quality using Shannon’s entropy. For validation, a supercontinuum light sources and a costume-made spectrometer with 400 nm bandwidth were combined with a high NA microscope objective in a setup for tissue and small animal imaging. Using this setup and computation corrections, volumetric imaging at 1.5 μm resolution is possible. Cellular and near cellular resolution is demonstrated in porcine cornea and the drosophila larva, when computational correction of dispersion and aberrations is used. Due to the excellent correction of the used microscope objective, defocus was the main contribution to the aberrations. In addition, higher aberrations caused by the sample itself were successfully corrected. Dispersion and aberrations are closely related artifacts in microscopic OCT imaging. Hence they can be corrected in the same way by optimization of the image quality. This way microscopic resolution is easily achieved in OCT imaging of static biological tissues.}, keywords = {OCM}, pubstate = {published}, tppubtype = {inproceedings} } |
2017
Sarah
Kretschmer,
Mario
Pieper,
Antje
Klinger,
Gereon
Hüttmann, and
Peter
König,
Imaging of Wound Closure of Small Epithelial Lesions in the Mouse Trachea, Am J Pathol , vol. 187, no. 11, pp. 2451-2460, Nov. 2017.
Imaging of Wound Closure of Small Epithelial Lesions in the Mouse Trachea, Am J Pathol , vol. 187, no. 11, pp. 2451-2460, Nov. 2017.
DOI: | 10.1016/j.ajpath.2017.07.006 |
Bibtex: | @article{Kretschmer2017, author = {Kretschmer, S; Pieper, M; Klinger, A; Hüttmann, G. and König, P.}, title = {Imaging of Wound Closure of Small Epithelial Lesions in the Mouse Trachea}, journal = {Am J Pathol}, ISSN = {0002-9440}, DOI = {10.1016/j.ajpath.2017.07.006}, year = {2017}, pages = {2451-2460}, type = {Journal Article} } |
Dierck
Hillmann,
Hendrik
Spahr,
Carola
Hain,
Laura
Hinkel,
Gesa
Franke, and
Gereon
Hüttmann,
Off-axis reference beam for full-field swept-source OCT and holoscopy, Opt Expr , vol. 25, no. 22, pp. 27770-27784, Okt. 2017.
Off-axis reference beam for full-field swept-source OCT and holoscopy, Opt Expr , vol. 25, no. 22, pp. 27770-27784, Okt. 2017.
DOI: | 10.1364/OE.25.027770 |
Bibtex: | @article{Hillmann2017, author = {Hillmann, D; Spahr, H; Sudkamp, H; Hain, C; Hinkel, L; Franke, G and Hüttmann, G}, title = {Off-axis reference beam for full-field swept-source OCT and holoscopy}, journal = {Opt Expr}, pages = {27770-27784}, DOI = {10.1364/OE.25.027770}, year = {2017}, type = {Journal Article} } |
Clara
Pfäffle,
Hendrik
Spahr,
Dierck
Hillmann,
Helge
Sudkamp,
Gesa
Franke,
Peter
Koch, and
Gereon
Hüttmann,
Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited], Biomedical Optics Express , vol. 8, no. 3, pp. 1499-1511, 03 2017. https://doi.org/10.1364/BOE.8.001499 .
Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited], Biomedical Optics Express , vol. 8, no. 3, pp. 1499-1511, 03 2017. https://doi.org/10.1364/BOE.8.001499 .
DOI: | 10.1364/BOE.8.001499 |
Weblink: | https://doi.org/10.1364/BOE.8.001499 |
Datei: | abstract.cfm |
Bibtex: | @article{Pfäffle2017, author = {Pfäffle, Clara and Spahr, Hendrik and Hillmann, Dierck and Sudkamp, Helge and Franke, Gesa and Koch, Peter and Hüttmann, Gereon}, title = {Reduction of frame rate in full-field swept-source optical coherence tomography by numerical motion correction [Invited]}, journal = {Biomedical Optics Express}, volume = {8}, number = {3}, pages = {1499-1511}, keywords = {Image reconstruction-restoration Optical coherence tomography}, url = {http://www.osapublishing.org/boe/abstract.cfm?URI=boe-8-3-1499}, year = {2017}, type = {Journal Article} } |
Malte
Casper,
Hinnerk
Schulz-Hildebrandt,
Michael
Evers,
Cuc
Nguyen,
Gereon
Hüttmann, and
Dieter
Manstein,
Imaging cold-induced vasodynamic behaviour in skin using OCT for microangiography (Conference Presentation), in Proceedings Volume 10037, Photonics in Dermatology and Plastic Surgery , Spie, Eds. 2017.
Imaging cold-induced vasodynamic behaviour in skin using OCT for microangiography (Conference Presentation), in Proceedings Volume 10037, Photonics in Dermatology and Plastic Surgery , Spie, Eds. 2017.
DOI: | doi: 10.1117/12.2251485 |
Bibtex: | @conference{Casper2017, title = {Imaging cold-induced vasodynamic behaviour in skin using OCT for microangiography (Conference Presentation)}, author = {Malte Casper and Hinnerk Schulz-Hildebrandt and Michael Evers and Cuc Nguyen and Reginald Birngruber and Gereon H\"{u}ttmann and Dieter Manstein}, editor = {Spie}, doi = {doi: 10.1117/12.2251485}, year = {2017}, date = {2017-04-19}, booktitle = {Proceedings Volume 10037, Photonics in Dermatology and Plastic Surgery}, volume = {10037OS}, abstract = {In dermatology the reflexes of vasoconstriction and vasodilation are known as important mechanisms of thermoregulation of the inner body. Imaging the physiology of microvasculature of the skin with high spatial resolution in three dimensions while reacting to changes in temperature is crucial for understanding the complex processes of vasodynamics, which result in constriction and dilation of vessels. However, previous studies using Laser-Doppler flowmetry and -imaging could not provide reliable angiographic images which allow to quantify changes in blood vessel diameter. Here, we report a different approach for angiographic imaging of microvasculature of a anaesthetized rodent model using speckle variance optical coherence tomography (svOCT) during and after localized cooling. Therefore a commercial OCT with a center wavelength of 1.3 μm and a spatial resolution of 13µm was used in combination with a custom built cooling device to image such reflexes at the mouse ear pinna and dorsal skinfold. Cooling was applied in steps of 2−5◦ C starting at the baseline temperature of 27◦ C down to −10◦ C. To our surprise and in contrast to the general opinion in literature, we were able to observe that the majority of vessels with a diameter larger than 20 μm maintain perfused with a constant diameter when the tissue is cooled from baseline to subzero temperatures. However, vasoconstriction was observed very rarely and only in veins, which led to their occlusion. The results of this experiment lead us to reconsider essential aspects of previous understanding of temperature-induced vasodynamics in cutaneous microvasculature.}, keywords = {}, pubstate = {published}, tppubtype = {conference} } |
Cuiping
Yao,
Florian
Rudnitzki,
Gereon
Hüttmann,
Zhenxi
Zhang, and
Ramtin
Rahmanzadeh,
Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation, International Journal of Nanomedicine , vol. 12, pp. 5659-5672, 2017.
Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation, International Journal of Nanomedicine , vol. 12, pp. 5659-5672, 2017.
DOI: | 10.2147/IJN.S140620 |
Bibtex: | @article{Yao2017, author = {Yao, C; Rudnitzki, F; Hüttmann, G; Zhang, Zand Rahmanzadeh, R}, title = {Important factors for cell-membrane permeabilization by gold nanoparticles activated by nanosecond-laser irradiation}, journal = {International Journal of Nanomedicine}, pages = {5659-5672}, DOI = {10.2147/IJN.S140620}, year = {2017}, type = {Journal Article} } |
Christian
Buj,
Michael
Münter,
Benedikt
Schmarbeck,
Jens
Horstmann,
Gereon
Hüttmann, and
Ralf
Brinkmann,
Noncontact holographic detection for photoacoustic tomography, J Biomed Opt , vol. 22, no. 10, pp. 1-14, 2017.
Noncontact holographic detection for photoacoustic tomography, J Biomed Opt , vol. 22, no. 10, pp. 1-14, 2017.
DOI: | 10.1117/1.jbo.22.10.106007 |
Bibtex: | @article{Buj2017, author = {Buj, C; Münter, M; Schmarbeck, B; Horstmann, J; Hüttmann, G and Brinkmann, R}, title = {Noncontact holographic detection for photoacoustic tomography}, journal = {J Biomed Opt}, pages = {1-14}, DOI = {10.1117/1.jbo.22.10.106007}, year = {2017}, type = {Journal Article} } |
2016
J.
Horstmann,
S.
Siebelmann,
I.
Glasunow,
A.
Schadschneider, and
Gereon
Hüttmann,
OCT verstehen – Teil 2: Praktische Aspekte und Anwendung, Augenheilkunde up2date , vol. 6, no. 04, pp. 305-320, Nov. 2016.
OCT verstehen – Teil 2: Praktische Aspekte und Anwendung, Augenheilkunde up2date , vol. 6, no. 04, pp. 305-320, Nov. 2016.
DOI: | 10.1055/s-0042-117459 |
Bibtex: | @article{Horstmann2016, author = {Horstmann, J. and Siebelmann, S. and Schulz-Hildebrandt, H. and Glasunow, I. and Schadschneider, A. and Hüttmann, G.}, title = {OCT verstehen – Teil 2: Praktische Aspekte und Anwendung}, journal = {Augenheilkunde up2date}, volume = {6}, number = {04}, pages = {305-320}, ISSN = {1616-9719}, DOI = {10.1055/s-0042-117459}, year = {2016}, type = {Journal Article} } |
Helge
Sudkamp,
Peter
Koch,
Hendrik
Spahr,
Dierck
Hillmann,
Gesa
Franke,
Michael
Münst,
Fred
Reinholz,
Reginald
Birngruber, and
Gereon
Hüttmann,
In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography, Optics Letters , vol. 41, no. 21, pp. 4987-4990, Nov. 2016.
In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography, Optics Letters , vol. 41, no. 21, pp. 4987-4990, Nov. 2016.
DOI: | 10.1364/OL.41.004987 |
Datei: | abstract.cfm |
Bibtex: | @article{RN4897, author = {Sudkamp, Helge and Koch, Peter and Spahr, Hendrik and Hillmann, Dierck and Franke, Gesa and Münst, Michael and Reinholz, Fred and Birngruber, Reginald and Hüttmann, Gereon}, title = {In-vivo retinal imaging with off-axis full-field time-domain optical coherence tomography}, journal = {Optics Letters}, volume = {41}, number = {21}, pages = {4987-4990}, DOI = {10.1364/OL.41.004987}, url = {http://ol.osa.org/abstract.cfm?URI=ol-41-21-4987}, year = {2016}, type = {Journal Article} } |
Hendrik
Spahr,
Dierck
Hillmann,
Carola
Hain,
Clara
Pfäffle,
Helge
Sudkamp,
Gesa
Franke,
Peter
Koch, and
Gereon
Hüttmann,
Darstellung von Blutfluss und Pulsation in retinalen Gefäßen mit Full-Field-Swept-Source-OCT, Klin Monatsbl Augenheilkd , vol. 233, no. 12, pp. 1324-1330, Okt. 2016.
Darstellung von Blutfluss und Pulsation in retinalen Gefäßen mit Full-Field-Swept-Source-OCT, Klin Monatsbl Augenheilkd , vol. 233, no. 12, pp. 1324-1330, Okt. 2016.
DOI: | 10.1055/s-0042-120279 |
Bibtex: | @article{Spahr2016, author = {Spahr, H. and Hillmann, D. and Hain, C. and Pfäffle, C. and Sudkamp, H. and Franke, G. and Koch, P. and Hüttmann, G.}, title = {Darstellung von Blutfluss und Pulsation in retinalen Gefäßen mit Full-Field-Swept-Source-OCT}, journal = {Klin Monatsbl Augenheilkd}, volume = {233}, number = {12}, pages = {1324-1330}, ISSN = {0023-2165}, DOI = {10.1055/s-0042-120279}, year = {2016}, type = {Journal Article} } |
Hinnerk
Schulz-Hildebrandt,
Mario
Pieper,
J.
Kasper,
N.
Traulsen,
M.
Mall,
Peter
König, and
Gereon
Hüttmann,
Towards automated evaluation of mucus transport measured by microscopic OCT (mOCT) during hypertonic saline treatment of Cystic Fibrosis, Pneumologie , vol. 70, no. 07, pp. 1-48, 07 2016.
Towards automated evaluation of mucus transport measured by microscopic OCT (mOCT) during hypertonic saline treatment of Cystic Fibrosis, Pneumologie , vol. 70, no. 07, pp. 1-48, 07 2016.
DOI: | 10.1055/s-0036-1584651 |
Bibtex: | @article{Schulz-Hildebrandt2016, author = {Schulz-Hildebrandt, H. and Pieper, M. and Kasper, J. and Traulsen, N. and Mall, M. and König, P. and Hüttmann, G.}, title = {Towards automated evaluation of mucus transport measured by microscopic OCT (mOCT) during hypertonic saline treatment of Cystic Fibrosis}, journal = {Pneumologie}, volume = {70}, number = {07}, pages = {1-48}, ISSN = {0934-8387}, DOI = {10.1055/s-0036-1584651}, year = {2016}, type = {Journal Article} } |