Publikationen

2024

N. Heldt, C. Holzhausen, M. Ahrens, M. Pieper, P. König, and G. Huettmann,
Reducing dOCT imaging time, in Abstract Book 12th DZL Annual Meeting , Deutsches Zentrum für Lungenforschung e. V Geschäftsstelle Aulweg 130 35392 Gießen: Deutsches Zentrum für Lungenforschung e. V, 062024. pp. 399.
Weblink: https://dzl.de/wp-content/uploads/2024/06/DZL2024_Abstract_Book-1.pdf
Datei: 2024-DZL_Annual_Meeting-Poster-short_sequences-Noah_Heldt.pdf
M. Dolling, L. Buhl, R. Birngruber, G. Hüttmann, and H. Schulz-Hildebrandt,
Algorithm and software for field distortion correction in a commercial SD-OCT for corneal curvature assessment, Appl. Opt. , vol. 63, no. 10, pp. 2694--2703, 2024. Optica Publishing Group.
DOI:10.1364/AO.505107
Datei: abstract.cfm
Bibtex: BibTeX
@article{Dolling:24,
author = {Maron Dolling and Lara Buhl and Reginald Birngruber and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},
journal = {Appl. Opt.},
keywords = {Distortion; Imaging systems; Optical aberration; Optical components; Spectral domain optical coherence tomography; Systems design},
number = {10},
pages = {2694--2703},
publisher = {Optica Publishing Group},
title = {Algorithm and software for field distortion correction in a commercial SD-OCT for corneal curvature assessment},
volume = {63},
month = {Apr},
year = {2024},
url = {https://opg.optica.org/ao/abstract.cfm?URI=ao-63-10-2694},
doi = {10.1364/AO.505107},
abstract = {Accurate assessment of corneal curvatures using frequency domain optical coherence tomography (OCT) with galvanometer scanners remains challenging due to the well-known scan field distortion. This paper presents an algorithm and software for correcting the distortion using only two simple measurements in which a readily available standard sphere is positioned in different depths in front of the OCT scanner. This offers a highly accessible and easily reproducible method for the field distortion correction (FDC). The correction was validated by measuring different spherical phantoms and conducting corneal curvature measurements of ex vivo porcine corneas using a commercial spectral-domain OCT system and a clinically approved swept-source OCT as a reference instrument. Thus, the error in radius measurements of spherical phantoms was reduced by \>90\% and astigmatism by \>80\% using FDC. In explanted porcine eyes, the error in astigmatism measurements with the Telesto was reduced by 75\% for power and 70\% for angle. The best fitting sphere radius was determined up to a deviation of 0.4\% from the Anterion. This paper describes a correction algorithm for OCT immanent distortion that is applicable to any scanning OCT setup and enables precise corneal curvature measurements. The MATLAB software for the FDC is publicly available on GitHub.},
}
G. Hüttmann,
Mathematical model for separating signal and noise in dynamic optical coherence tomography (dOCT), in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2024. pp. PC1283029.
DOI:10.1117/12.3005716
Weblink: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC12830/PC1283029/Mathematical-model-for-separating-signal-and-noise-in-dynamic-optical/10.1117/12.3005716.short
Bibtex: BibTeX
@inproceedings{10.1117/12.3005716,
author = {Gereon Hüttmann},
title = {Mathematical model for separating signal and noise in dynamic optical coherence tomography (dOCT)},
volume = {PC12830},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {PC1283029},
abstract = {Dynamic optical coherence tomography (dOCT) uses signal fluctuation for contrasting different cellular and acellular components in living biological tissue. The autocorrelation or Fourier transform of time series of OCT measurements are converted to a color contrast. However, a quantitative analysis is still challenging. Here we investigate theoretically, how noise of the OCT measurement influences the fluctuation spectra. Probability functions are derived for the different components in the spectra and validated by numerical simulation. With an appropriate calibration of the OCT device a separation of OCT noise and a quantification the dynamic OCT should be feasible.},
keywords = {Optical coherence tomography (OCT), Dynamic optical coherence tomography (OCT), Signal to noise, Speckle statistics, Quantification},
year = {2024},
doi = {10.1117/12.3005716},
URL = {https://doi.org/10.1117/12.3005716}
}
C. Pfäffle, L. Puyo, H. Spahr, D. Hillmann, Y. Miura, and G. Hüttmann,
Unraveling the Functional Signals of Rods and Cones in the Human Retina: Separation and Analysis, Frontiers in Ophthalmology , vol. 4, 2024.
DOI:10.3389/fopht.2024.1340692
Datei: fopht.2024.1340692
Bibtex: BibTeX
@ARTICLE{10.3389/fopht.2024.1340692,
  
AUTHOR={Pfäffle, Clara and Puyo, Léo and Spahr, Hendrik and Hillmann, Dierck and Miura, Yoko and Hüttmann, Gereon},   
	 
TITLE={Unraveling the Functional Signals of Rods and Cones in the Human Retina: Separation and Analysis},      
	
JOURNAL={Frontiers in Ophthalmology},      
	
VOLUME={4},           
	
YEAR={2024},      
	  
URL={https://www.frontiersin.org/articles/10.3389/fopht.2024.1340692},       
	
DOI={10.3389/fopht.2024.1340692},      
	
ISSN={2674-0826}   
   
}
A. Singh, M. Göb, M. Ahrens, T. Eixmann, B. Schulte, H. Schulz-Hildebrandt, G. Hüttmann, M. Ellrichmann, R. Huber, and M. Rahlves,
Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization, Opt. Express , vol. 32, no. 4, pp. 5809--5825, 2024. Optica Publishing Group.
DOI:10.1364/OE.514636
Bibtex: BibTeX
@article{Singh:24,
author = {Awanish Pratap Singh and Madita G\"{o}b and Martin Ahrens and Tim Eixmann and Berenice Schulte and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Mark Ellrichmann and Robert Huber and Maik Rahlves},
journal = {Opt. Express},
keywords = {Biomedical imaging; Endoscopic imaging; Imaging systems; Optical coherence tomography; Real time imaging; Vertical cavity surface emitting lasers},
number = {4},
pages = {5809--5825},
publisher = {Optica Publishing Group},
title = {Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization},
volume = {32},
month = {Feb},
year = {2024},
url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-32-4-5809},
doi = {10.1364/OE.514636},
abstract = {Circumferential scanning in endoscopic imaging is crucial across various disciplines, and optical coherence tomography (OCT) is often the preferred choice due to its high-speed, high-resolution, and micron-scale imaging capabilities. Moreover, real-time and high-speed 3D endoscopy is a pivotal technology for medical screening and precise surgical guidance, among other applications. However, challenges such as image jitter and non-uniform rotational distortion (NURD) are persistent obstacles that hinder real-time visualization during high-speed OCT procedures. To address this issue, we developed an innovative, low-cost endoscope that employs a brushless DC motor for scanning, and a sensorless technique for triggering and synchronizing OCT imaging with the scanning motor. This sensorless approach uses the motor\&\#x2019;s electrical feedback (back electromotive force, BEMF) as a virtual Hall sensor to initiate OCT image acquisition and synchronize it with a Fourier Domain Mode-Locked (FDML)-based Megahertz OCT system. Notably, the implementation of BEMF-triggered OCT has led to a substantial reduction in image jitter and NURD (\<4 mrad), thereby opening up a new window for real-time visualization capabilities. This approach suggests potential benefits across various applications, aiming to provide a more accurate, deployable, and cost-effective solution. Subsequent studies can explore the adaptability of this system to specific clinical scenarios and its performance under practical endoscopic conditions.},
}
N. Heldt, C. Holzhausen, M. Ahrens, M. Pieper, P. König, and G. Hüttmann,
Improved image quality in dynamic OCT imaging by reduced imaging time and machine learning based data evaluation, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2024. pp. PC128302A.
DOI:10.1117/12.3005413
Weblink: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC12830/PC128302A/Improved-image-quality-in-dynamic-OCT-imaging-by-reduced-imaging/10.1117/12.3005413.full
Bibtex: BibTeX
@inproceedings{10.1117/12.3005413,
author = {Noah Heldt and Cornelia Holzhausen and Martin Ahrens and Mario Pieper and Peter K{\"o}nig and Gereon H{\"u}ttmann},
title = {{Improved image quality in dynamic OCT imaging by reduced imaging time and machine learning based data evaluation}},
volume = {PC12830},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {PC128302A},
abstract = {Dynamic Optical Coherence Tomography combines high resolution tomographic imagery with a cell specific contrast by Fourier analysis. However, the conversion from frequency space into RGB images by binning requires a priori knowledge and artifacts due to global movements provide another obstacle for in vivo application.
We could show that an automated binning based on the Neural Gas algorithm can yield the highest spectral contrast without a priori knowledge and that motion artifacts can be reduced with shorter sequence lengths. Imaging murine airways, we observed that even just 6 frames are enough to generate dOCT images without losing important image information.},
keywords = {Dynamic OCT, Optical Coherence Tomography, Airways, Artificial Intelligence},
year = {2024},
doi = {10.1117/12.3005413},
URL = {https://doi.org/10.1117/12.3005413}
}

2023

N. Heldt, C. Holzhausen, M. Ahrens, M. Pieper, P. König, and G. Hüttmann,
Improved image quality in dynamic OCT imaging of airway and lung tissue by reduced imaging time and machine learning based data evaluation, in Abstract Book 11th DZL Annual Meeting , 11th DZL Annual Meeting, Fürstenfeldbruck, 14–16 June 2023, Deutsches Zentrum für Lungenforschung e. V Geschäftsstelle Aulweg 130 35392 Gießen: Deutsches Zentrum für Lungenforschung e. V, 072023. pp. 357.
Weblink: https://dzl.de/wp-content/uploads/2023/06/Abstract-Book_2023-2.pdf
Datei: Dateilink
A. Leichtle, Z. Penxova, T. Kempin, D. Leffers, M. Ahrens, P. König, R. Brinkmann, G. Hüttmann, K. Bruchhage, and H. Schulz-Hildebrandt,
Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media, Photonics , vol. 10, no. 6, 06 2023.
DOI:10.3390/photonics10060685
Datei: 685
Bibtex: BibTeX
@Article{photonics10060685,
AUTHOR = {Leichtle, Anke and Penxova, Zuzana and Kempin, Thorge and Leffers, David and Ahrens, Martin and König, Peter and Brinkmann, Ralf and Hüttmann, Gereon and Bruchhage, Karl-Ludwig and Schulz-Hildebrandt, Hinnerk},
TITLE = {Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media},
JOURNAL = {Photonics},
VOLUME = {10},
YEAR = {2023},
NUMBER = {6},
ARTICLE-NUMBER = {685},
URL = {https://www.mdpi.com/2304-6732/10/6/685},
ISSN = {2304-6732},
ABSTRACT = {Hypothesis: Otitis media (OM) can be successfully visualized and diagnosed by dynamic microscopic optical coherence tomography (dmOCT). Background: OM is one of the most common infectious diseases and, according to the WHO, one of the leading health problems with high mortality in developing countries. Despite intensive research, the only definitive treatment of therapy-refractory OM for decades has been the surgical removal of inflamed tissue. Thereby, the intra-operative diagnosis is limited to the surgeon’s visual impression. Supportive imaging modalities have been little explored and have not found their way into clinical application. Finding imaging techniques capable of identifying inflamed tissue intraoperatively, therefore, is of significant clinical relevance. Methods: This work investigated a modified version of optical coherence tomography with a microscopic resolution (mOCT) regarding its ability to differentiate between healthy and inflamed tissue. Despite its high resolution, the differentiation of single cells with mOCT is often impossible. A new form of mOCT termed dynamic mOCT (dmOCT) achieves cellular contrast using micro-movements within cells based on their metabolism. It was used in this study to establish correlative measurements with histology. Results: Using dmOCT, images with microscopic resolution were acquired on ex vivo tissue samples of chronic otitis media and cholesteatoma. Imaging with dmOCT allowed the visualization of specific and characteristic cellular and subcellular structures in the cross-sectional images, which can be identified only to a limited extent in native mOCT. Conclusion: We demonstrated for the first time a new marker-free visualization in otitis media based on intracellular motion using dmOCT.},
DOI = {10.3390/photonics10060685}
}
A. Altmann, M. Eden, G. Hüttmann, C. Schell, and R. Rahmanzadeh,
Porphyrin-based sensor films for monitoring food spoilage, Food Packaging and Shelf Life , vol. 38, pp. 101105, 06 2023.
DOI:https://doi.org/10.1016/j.fpsl.2023.101105
Datei: S2214289423000820
Bibtex: BibTeX
@article{ALTMANN2023101105,
title = {Porphyrin-based sensor films for monitoring food spoilage},
journal = {Food Packaging and Shelf Life},
volume = {38},
pages = {101105},
year = {2023},
issn = {2214-2894},
doi = {https://doi.org/10.1016/j.fpsl.2023.101105},
url = {https://www.sciencedirect.com/science/article/pii/S2214289423000820},
author = {Alexander Altmann and Michel Eden and Gereon Hüttmann and Christian Schell and Ramtin Rahmanzadeh},
keywords = {Biogenic amines, Sensors, Fish freshness, Food safety, Porphyrin, Smart packaging},
abstract = {To increase food safety and to minimize food waste, it is interesting for the food industry and consumers to be able to determine food spoilage continuously and non-destructively. When food of animal origin is degraded, amines are released as protein breakdown products, which could be used to monitor the freshness of meat and fish. In this work, we introduce a porphyrin-based sensor foil aimed at the detection of biogenic amines. The sensor-porphyrin is formulated on mesoporous silica. Reactivity towards moderate humidity was eliminated by dispersion of the functionalized silica in polyethylene (PE), followed by thermal extrusion resulting in PE foils. After exposure to amines, the sensor foil changes its color irreversibly from green to red. The color change is accompanied by a pronounced shift of the fluorescence spectrum, which was used as a sensitive method to detect the degradation of fish products in model experiments. Titanium dioxide particles in the foil increased the detected fluorescence emission. Experiments with fish filets showed the applicability of the sensor foils in a real-life application by indicating the degree of spoilage after several days, while the microbial growth was depicted by total viable count. We anticipate that our sensor can be an integral part of smart food packages, helping to track the freshness of food during transport or storage.}
}
S. Latus, S. Grube, T. Eixmann, M. Neidhardt, S. Gerlach, R. Mieling, G. Hüttmann, M. Lutz, and A. Schlaefer,
A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography, IEEE Transactions on Biomedical Engineering , pp. 1-9, 05 2023.
DOI:10.1109/TBME.2023.3275539
Bibtex: BibTeX
@ARTICLE{10122996,

  author={Latus, Sarah and Grube, Sarah and Eixmann, Tim and Neidhardt, Maximilian and Gerlach, Stefan and Mieling, Robin and Hüttmann, Gereon and Lutz, Matthias and Schlaefer, Alexander},

  journal={IEEE Transactions on Biomedical Engineering}, 

  title={A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography}, 

  year={2023},

  volume={},

  number={},

  pages={1-9},

  doi={10.1109/TBME.2023.3275539}}
A. Singh, M. Göb, M. Ahrens, T. Eixmann, H. Schulz-Hildebrandt, G. Hüttmann, R. Huber, and M. Rahlves,
Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236703.
DOI:10.1117/12.2652955
Bibtex: BibTeX
@inproceedings{10.1117/12.2652955,
author = {Awanish Pratap Singh and Madita G{\"o}b and Martin Ahrens and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H{\"u}ttmann and Robert Huber and Maik Rahlves},
title = {{Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop}},
volume = {12367},
booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII},
editor = {Joseph A. Izatt and James G. Fujimoto},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {1236703},
abstract = {High-speed endoscopic optical coherence tomography (OCT) imaging in the MHz range has shown great potential in various medical applications ranging from cancer screening to vascular disease monitoring. High-speed imaging always suffers from non-uniform rotational distortion (NURD) due to asynchronous motor rotation with the OCT system. Several research groups have previously attempted to solve this problem, using either an expensive motor with a sensor or numerical correction after data acquisition. However, both techniques pose challenges for practical use. Therefore, in this study, we use an inexpensive sensorless brushless DC motor with a Fourier domain mode-locked (FDML) laser-based MHz OCT system and try to resolve the problem of synchronization using three different modalities, (i) Slave-mode: The FDML frequency serves as a master frequency for the motor, which is phase-locked to the FDML frequency, (ii) Master-mode: The revolution trigger obtained from the motor’s back electromotive force (BEMF) signal serves as a trigger signal for the OCT imaging system, (iii) Both: Fully synchronized setup, where the motor rotation is synchronized with the laser and the imaging system is synchronized with the motor to achieve phase-stable OCT imaging. The first case slightly fluctuates in live preview and imaging due to the absence of a revolution trigger, while the second has varying motor speeds. Therefore, we use the third case to phase-lock the motor with FDML and get a distortion-free live preview and image acquisition. Finally, we demonstrate high-speed SS-OCT structural imaging (at 3.3 MHz A-scan rates) of a finger with a 16 mm diameter probe (at 40,000 rpm).},
keywords = {Optical Coherence Tomography, Endoscopy, FDML , Closed Loop Motor Control, NURD compensation, Brushless DC Motor, Back Electromotive Force},
year = {2023},
doi = {10.1117/12.2652955},
URL = {https://doi.org/10.1117/12.2652955}
}
L. Puyo, C. Pfäffle, H. Spahr, J. Franke, D. Bublitz, D. Hillmann, and G. Hüttmann,
Diffuse-illumination holographic optical coherence tomography, Opt. Express , vol. 31, no. 20, pp. 33500--33517, 2023. Optica Publishing Group.
DOI:10.1364/OE.498654
Datei: abstract.cfm
Bibtex: BibTeX
@article{Puyo:23,
author = {L\'{e}o Puyo and Clara Pf\"{a}ffle and Hendrik Spahr and Jonas Franke and Daniel Bublitz and Dierck Hillmann and Gereon H\"{u}ttmann},
journal = {Opt. Express},
keywords = {Fourier optics; Full field optical coherence tomography; Image quality; Imaging techniques; Spatial frequency; Spatial light modulators},
number = {20},
pages = {33500--33517},
publisher = {Optica Publishing Group},
title = {Diffuse-illumination holographic optical coherence tomography},
volume = {31},
month = {Sep},
year = {2023},
url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-31-20-33500},
doi = {10.1364/OE.498654},
abstract = {Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing diffuse illumination of numerical aperture (NA) equal to the detection NA. While the reduction of speckle from singly scattered light is only modest, we discovered that speckle from multiply scattered light can be arbitrarily reduced, resulting in substantial improvements in image quality. This technique also offers the advantage of suppressing noises arising from spatial coherence, and can be implemented with a partially spatially incoherent light source for further mitigation of multiple scattering. Finally, we show that although holographic reconstruction capabilities are increasingly lost with decreasing spatial coherence, they can be retained over an axial range sufficient to standard OCT applications.},
}

2022

C. Pfäffle, H. Spahr, K. Gercke, L. Puyo, S. Höhl, D. Melenberg, Y. Miura, G. Hüttmann, and D. Hillmann,
Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer, Frontiers in Medicine , vol. 9, 06 2022.
DOI:10.3389/fmed.2022.885187
Datei: fmed.2022.885187
Bibtex: BibTeX
@article{RN5328,
   author = {Pfäffle, C;Spahr, H;Gercke, K;Puyo, L;Höhl, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer},
   journal = {Frontiers in Medicine},
   volume = {9},
   ISSN = {2296-858X},
   DOI = {10.3389/fmed.2022.885187},
keywords = {optoretinography, optical coherence tomography, phase-sensitive OCT, functional imaging, inner
plexiform layer, retina},
   url = {https://www.frontiersin.org/articles/10.3389/fmed.2022.885187},
   year = {2022},
   type = {Journal Article}
}
C. von der Burchard, H. Sudkamp, J. Tode, C. Ehlken, K. Purtskhvanidze, M. Moltmann, B. Heimes, P. Koch, M. Münst, M. vom Endt, T. Kepp, D. Theisen-Kunde, I. König, G. Hüttmann, and J. Roider,
Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study, BMJ Open , vol. 12, no. 6, pp. e055082, 2022.
DOI:10.1136/bmjopen-2021-055082
Datei: e055082.abstract
Bibtex: BibTeX
@article{von-der-Burchardt2022,
   author = {von der Burchard, C;Sudkamp, H;Tode, J;Ehlken, C;Purtskhvanidze, K;Moltmann, M;Heimes, B;Koch, P;Münst, M;vom Endt, M;Kepp, T;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J},
   title = {Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study},
   journal = {BMJ Open},
   volume = {12},
   number = {6},
   pages = {e055082},
   DOI = {10.1136/bmjopen-2021-055082},
   url = {http://bmjopen.bmj.com/content/12/6/e055082.abstract},
   year = {2022},
   type = {Journal Article}
}
T. Kohlfaerber, M. Pieper, M. Münter, C. Holzhausen, M. Ahrens, C. Idel, L. Bruchhage, A. Leichtle, P. König, G. Hüttmann, and H. Schulz-Hildebrandt,
Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways, Biomedical Optics Express , vol. 13 (6), pp. 3211-3223, 2022.
DOI:10.1364/BOE.456104
Bibtex: BibTeX
@article{Kohlfarber2022,
   author = {Kohlfaerber, T;Pieper, M;Münter, M;Holzhausen, C;Ahrens, M;Idel, C;Bruchhage, K-L;Leichtle, A;König, P;Hüttmann, G and Schulz-Hildebrandt, H},
   title = {Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways},
   journal = {Biomedical Optics Express},
   volume = {13 (6)},
   pages = {3211-3223},
   DOI = {10.1364/BOE.456104},
  
   year = {2022},
   type = {Journal Article}
}
P Musial, T. Kohlfaerber, M. Ahrens, H. Schulz-Hildebrandt, P. Steven, and G. Hüttmann,
Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride, Translational Vision Science & Technology , vol. 11(5), pp. 28-28, 2022.
DOI:10.1167/tvst.11.5.28
Datei: tvst.11.5.28
Bibtex: BibTeX
@article{Musial-2022,
   author = {Musial, G;Kohlfaerber, T;Ahrens, M;Schulz-Hildebrandt, H;Steven, P and Hüttmann, G},
   title = {Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride},
   journal = {Translational Vision Science & Technology},
keywords = {toxicity; optical coherence tomography; benzalkonium chloride},
   volume = {11(5)},

   pages = {28-28},
   ISSN = {2164-2591},
   DOI = {10.1167/tvst.11.5.28},
   url = {https://doi.org/10.1167/tvst.11.5.28},
   year = {2022},
   type = {Journal Article}
}

2021

C. Pfäffle, H. Spahr, K. Gercke, S. Burhan, D. Melenberg, Y. Miura, G. Hüttmann, and D. Hillmann,
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, 082021.
DOI:10.1117/12.2577605
Bibtex: BibTeX
@inproceedings{RN5321,
   author = {Pfäffle, C;Spahr, H;Gercke, K;Burhan, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D},
   title = {Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer},
   booktitle = {SPIE BiOS},
   publisher = {SPIE},
   volume = {11623},
   url = {https://doi.org/10.1117/12.2577605},
   type = {Conference Proceedings}
}
H. Hakert, M. Eibl, M. Tillich, R. Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, L. Bruchhage, S. Karpf, and R. Huber,
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
DOI:10.1364/OL.424726
Bibtex: BibTeX
@article{Hakert2021,
   author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber},
   title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800  cm-1},
   journal = {Optics Letters},
   volume = {46(14)},
   number = {14},
   pages = {3456-3459},
keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering},
   DOI = {https://doi.org/10.1364/OL.424726},
   year = {2021},
   type = {Journal Article}
}
T. Peñate Medina, J. Kolb, G. Hüttmann, R. Huber, O. Peñate Medina, N. Larsen, A. Ferrari, M. Rafecas, M. Ellrichmann, M. Pravdivtseva, M. Anikeeva, J. Humbert, M. Both, J. Hundt, and J. Hövener,
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
DOI:10.3389/fimmu.2021.692222
Bibtex: BibTeX
@article{PenateMedina2021,
   author = {Peñate Medina, T;Kolb, J P;Hüttmann, G;Huber, R;Peñate Medina, O;Ha, L;Ulloa, P;Larsen, N;Ferrari, A;Rafecas, M;Ellrichmann, M;Pravdivtseva, M S.;Anikeeva, M;Humbert, J;Both, M;Hundt, J E. and Hövener, J-B},
   title = {Imaging Inflammation - From Whole Body Imaging to Cellular Resolution},
   journal = {Frontiers in immunology},
keywords = {AG-Huber, MRI, PET, SPECT, optical imaging, Optical coherence tomography (OCT), precision medicine, Two-Photon microscopy (TPM), hyperpolarization},
   volume = {12},
   pages = {692222-692222},
   ISSN = {1664-3224},
   DOI = {10.3389/fimmu.2021.692222},
   url = {https://pubmed.ncbi.nlm.nih.gov/34248987
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264453/},
   year = {2021},
   type = {Journal Article}
}
M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann, and H. Schulz-Hildebrandt,
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
DOI:10.1364/BOE.425001
Bibtex: BibTeX
@article{Münter2021,
   author = {M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann and H. Schulz-Hildebrandt},
   title = {Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast},
   journal = {BiomedOptE},
   volume = {12(10)},
   Keywords = {CMOS cameras,Full field optical coherence tomography,High numerical aperture optics, Image processing,In vivo imaging,Medical imaging,Ag-Huber},
   pages = {6024-6039},
   DOI = {10.1364/BOE.425001},
  
   year = {2021},
   type = {Journal Article}
}
M. Ahrens, C. Idel, P. König, G. Hüttmann, and H. Schulz-Hildebrandt,
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI:10.1117/12.2578787
Datei: 12.2578787
Bibtex: BibTeX
@inproceedings{10.1117/12.2578787,

title = {Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination},

author = {Martin Ahrens and Christian Idel and Peter K\"{o}nig and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},

editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter},

url = {https://doi.org/10.1117/12.2578787},

doi = {10.1117/12.2578787},

year  = {2021},

date = {2021-01-01},

booktitle = {Endoscopic Microscopy XVI},

volume = {11620},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
F. Hilge, M. Evers, M. Casper, J. Glahn, W. M.D., G. M.D., H. Schulz-Hildebrandt, G. Hüttmann, and D. M.D.,
Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography, in Photonics in Dermatology and Plastic Surgery 2021 , Bernard Choi and Haishan Zeng, Eds. SPIE, 2021.
DOI:10.1117/12.2577822
Datei: 12.2577822
Bibtex: BibTeX
@inproceedings{10.1117/12.2577822,

title = {Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography},

author = {Felix Hilge and Michael Evers and Malte Casper and Joshua Zev Glahn and Weeranut Phothong M.D. and Garuna Kositratna M.D. and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Dieter Manstein M.D.},

editor = {Bernard Choi and Haishan Zeng},

url = {https://doi.org/10.1117/12.2577822},

doi = {10.1117/12.2577822},

year  = {2021},

date = {2021-01-01},

booktitle = {Photonics in Dermatology and Plastic Surgery 2021},

volume = {11618},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
S. Jäckle, A. Lange, V. Garcia-Vazquez, T. Eixmann, F. Matysiak, M. Sieren, M. Horn, G. Hüttmann, H. Schulz-Hildebrandt, F. Ernst, S. Heldmann, T. Pätz, and T. Preusser,
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
DOI:10.1002/rcs.2327
Bibtex: BibTeX
@article{Jackle2021,
abstract = {Background: In endovascular aneuysm repair (EVAR) procedures, medical instruments are currently navigated with a two-dimensional imaging based guidance requiring X-rays and contrast agent. Methods: Novel approaches for obtaining the three-dimensional instrument positions are introduced. Firstly, a method based on fibre optical shape sensing, one electromagnetic sensor and a preoperative computed tomography (CT) scan is described. Secondly, an approach based on image processing using one 2D fluoroscopic image and a preoperative CT scan is introduced. Results: For the tracking based method, average errors from 1.81 to 3.13 mm and maximum errors from 3.21 to 5.46 mm were measured. For the image-based approach, average errors from 3.07 to 6.02 mm and maximum errors from 8.05 to 15.75 mm were measured. Conclusion: The tracking based method is promising for usage in EVAR procedures. For the image-based approach are applications in smaller vessels more suitable, since its errors increase with the vessel diameter.},
author = {J{\"{a}}ckle, Sonja and Lange, Annkristin and Garcia-Vazquez, Veronica and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and Ernst, Floris and Heldmann, Stefan and P{\"{a}}tz, Torben and Preusser, Tobias},
doi = {10.1002/rcs.2327},
file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Medical Robotics and Computer Assisted Surgery/J{\"{a}}ckle et al. - 2021 - Instrument localisation for endovascular aneurysm repair Comparison of two methods based on tracking systems or.pdf:pdf},
issn = {1478596X},
journal = {International Journal of Medical Robotics and Computer Assisted Surgery},
keywords = {2D/3D registration,3D localisation,computer-assisted surgery,electromagnetic tracking system,endovascular procedures,fibre optical shape sensing},
number = {6},
pages = {e2327},
year = {2021},
title = {{Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging}},
volume = {17}
}
M. Wunderlich, P. Koch, H. Sudkamp, M. Münst, M. Endt, M. Moltmann, and G. Hüttmann,
Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms, in Ophthalmic Technologies XXXI , Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker, Eds. SPIE, 2021. pp. 116231Q.
DOI:10.1117/12.2583030
Datei: 12.2583030
Bibtex: BibTeX
@inproceedings{10.1117/12.2583030,
author = {Michel Wunderlich and Peter Koch and Helge Sudkamp and Michael M{\"u}nst and Malte vom Endt and Moritz Moltmann and Gereon H{\"u}ttmann},
title = {{Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms}},
volume = {11623},
booktitle = {Ophthalmic Technologies XXXI},
editor = {Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker},
organization = {International Society for Optics and Photonics},
publisher = {SPIE},
pages = {116231Q},
keywords = {Retinal motion tracking in Off-Axis Full-Field OCT by local analy, Michel Wunderlich, Medizinsches Laserzentrum Lübeck, motion tracking, eye tracking, off-axis full-field time-domain OCT, OCT, retina},
year = {2021},
doi = {10.1117/12.2583030},
URL = {https://doi.org/10.1117/12.2583030}
}
H. Schulz-Hildebrandt, M. Ahrens, E. Wilken, C. Holzhausen, P. König, and G. Hüttmann,
Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI:10.1117/12.2575733
Datei: 12.2575733
Bibtex: BibTeX
@inproceedings{10.1117/12.2575733,

title = {Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast},

author = {Hinnerk Schulz-Hildebrandt and Martin Ahrens and Michael M\"{u}nter and Elisa Wilken and Tabea Kohlf\"{a}rber and Cornelia Holzhausen and Peter K\"{o}nig and Gereon H\"{u}ttmann},

editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter},

url = {https://doi.org/10.1117/12.2575733},

doi = {10.1117/12.2575733},

year  = {2021},

date = {2021-01-01},

booktitle = {Endoscopic Microscopy XVI},

volume = {11620},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
T. Kohlfaerber, M. Pieper, P. König, R. Rahmanzadeh, G. Hüttmann, and H. Schulz-Hildebrandt,
Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A Izatt and James G Fujimoto, Eds. SPIE, 2021.
DOI:10.1117/12.2583811
Datei: 12.2583811
Bibtex: BibTeX
@inproceedings{10.1117/12.2583811,

title = {Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea},

author = {Tabea Kohlfaerber and Michael M\"{u}nter and Mario Pieper and Peter K\"{o}nig and Ramtin Rahmanzadeh and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt},

editor = {Joseph A Izatt and James G Fujimoto},

url = {https://doi.org/10.1117/12.2583811},

doi = {10.1117/12.2583811},

year  = {2021},

date = {2021-01-01},

booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV},

volume = {11630},

publisher = {SPIE},

organization = {International Society for Optics and Photonics},

keywords = {},

pubstate = {published},

tppubtype = {inproceedings}

}
M. Cereda, Y. Douven, K. Faridpooya, G. Hüttmann, T. Eixmann, H. Schulz-Hildebrandt, G. Kronreif, S. van Romunde, M. Beelen, and M. de Smet,
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
DOI:https://doi.org/10.1016/j.xops.2021.100085
Bibtex: BibTeX
@article{Cereda-2021,
   author = {Cereda, M G;Parrulli, S;Douven, Y. G. M.;Faridpooya, K;van Romunde, S;Hüttmann, G;Eixmann, T;Schulz-Hildebrandt, H;Kronreif, G;Beelen, M and de Smet, M D.},
   title = {Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery},
   journal = {Ophthalmology Science},
   volume = {1(4)},
  
   pages = {100085},
   ISSN = {2666-9145},
   DOI = {https://doi.org/10.1016/j.xops.2021.100085},
  
   year = {2021},
   type = {Journal Article}
}
S. Jäckle, T. Eixmann, F. Matysiak, M. Sieren, M. Horn, H. Schulz-Hildebrandt, G. Hüttmann, and T. Pätz,
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
DOI:doi:10.1515/cdbme-2021-1004
Datei: cdbme-2021-1004
Bibtex: BibTeX
@article{Jaeckle2021c,
author = {J{\"{a}}ckle, Sonja and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and P{\"{a}}tz, Torben},
doi = {doi:10.1515/cdbme-2021-1004},
journal = {Current Directions in Biomedical Engineering},
year = {2021},
number = {1},
pages = {17--20},
title = {{3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair:}},
url = {https://doi.org/10.1515/cdbme-2021-1004},
volume = {7},
}

2020

C. von der Burchard, M. Moltmann, J. Tode, C. Ehlken, H. Sudkamp, D. Theisen-Kunde, I. König, G. Hüttmann, and J. Roider,
Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases, Graefe's Archive for Clinical and Experimental Ophthalmology , Dez. 2020.
Datei: s00417-020-05035-6
Bibtex: BibTeX
@article{von-derBurchard2020,
   author = {von der Burchard, C;Moltmann, M.;Tode, J;Ehlken, C;Sudkamp, H;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J},
   title = {Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases},
   journal = {Graefe's Archive for Clinical and Experimental Ophthalmology},
   ISSN = {1435-702X},
   
   url = {https://doi.org/10.1007/s00417-020-05035-6},
   year = {2020},
   type = {Journal Article}
}
T. Fischer, A. Klinger, D. Smolinski, R. Orzekowsky-Schröder, F. Nitzsche, A. Vogel, G. Hüttmann, and A. Gebert,
High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , pp. 1-8, 2020.
Datei: s00441-020-03167-z
Bibtex: BibTeX
@article{Fischer2020,
   author = {Fischer, T;Klinger, A;von Smolinski, D;Orzekowsky-Schroeder, R;Nitzsche, F;Bölke, T;Vogel, A;Hüttmann, G and Gebert, A},
   title = {High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures},
   journal = {Cell and Tissue Research},
   pages = {1-8},
   ISSN = {1432-0878},
   url = {https://doi.org/10.1007/s00441-020-03167-z},
   year = {2020},
   type = {Journal Article}
}